WO2019233671A1 - Verfahren zur herstellung einer zusammensetzung enthaltend zumindest eine metall-aminosäure-verbindung sowie zusammensetzung erhältlich durch ein derartiges verfahren - Google Patents
Verfahren zur herstellung einer zusammensetzung enthaltend zumindest eine metall-aminosäure-verbindung sowie zusammensetzung erhältlich durch ein derartiges verfahren Download PDFInfo
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- WO2019233671A1 WO2019233671A1 PCT/EP2019/060351 EP2019060351W WO2019233671A1 WO 2019233671 A1 WO2019233671 A1 WO 2019233671A1 EP 2019060351 W EP2019060351 W EP 2019060351W WO 2019233671 A1 WO2019233671 A1 WO 2019233671A1
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- Prior art keywords
- metal
- amino acid
- composition
- compound
- water
- Prior art date
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- 229910052751 metal Inorganic materials 0.000 title claims abstract description 73
- 239000002184 metal Substances 0.000 title claims abstract description 73
- 239000000203 mixture Substances 0.000 title claims abstract description 35
- 238000000034 method Methods 0.000 title claims abstract description 24
- 238000004519 manufacturing process Methods 0.000 title abstract description 5
- -1 amino acid compound Chemical class 0.000 title abstract 2
- 238000006243 chemical reaction Methods 0.000 claims abstract description 31
- 150000003839 salts Chemical class 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 150000007514 bases Chemical class 0.000 claims abstract description 16
- 235000008206 alpha-amino acids Nutrition 0.000 claims abstract description 14
- 239000008247 solid mixture Substances 0.000 claims abstract description 5
- 238000010438 heat treatment Methods 0.000 claims abstract description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 32
- 239000004471 Glycine Substances 0.000 claims description 16
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 claims description 12
- 239000010949 copper Substances 0.000 claims description 10
- 230000005855 radiation Effects 0.000 claims description 10
- 230000008569 process Effects 0.000 claims description 9
- 239000007921 spray Substances 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 6
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 5
- 229910052802 copper Inorganic materials 0.000 claims description 5
- 150000002736 metal compounds Chemical class 0.000 claims description 5
- 150000002739 metals Chemical class 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
- 150000001450 anions Chemical class 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- 229910052742 iron Inorganic materials 0.000 claims description 2
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 2
- 229930182852 proteinogenic amino acid Natural products 0.000 claims description 2
- 238000001694 spray drying Methods 0.000 claims description 2
- 239000005749 Copper compound Substances 0.000 claims 3
- 150000001880 copper compounds Chemical class 0.000 claims 3
- 229910000365 copper sulfate Inorganic materials 0.000 claims 3
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims 3
- 230000011514 reflex Effects 0.000 claims 1
- 150000003752 zinc compounds Chemical class 0.000 claims 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims 1
- 229910000368 zinc sulfate Inorganic materials 0.000 claims 1
- 229960001763 zinc sulfate Drugs 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 abstract description 34
- 150000001371 alpha-amino acids Chemical class 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 description 33
- 238000003756 stirring Methods 0.000 description 12
- 150000001768 cations Chemical class 0.000 description 10
- 239000000047 product Substances 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- 229940116318 copper carbonate Drugs 0.000 description 8
- GEZOTWYUIKXWOA-UHFFFAOYSA-L copper;carbonate Chemical compound [Cu+2].[O-]C([O-])=O GEZOTWYUIKXWOA-UHFFFAOYSA-L 0.000 description 8
- 238000005469 granulation Methods 0.000 description 5
- 230000003179 granulation Effects 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 150000003819 basic metal compounds Chemical class 0.000 description 4
- 239000006227 byproduct Substances 0.000 description 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 4
- 239000007795 chemical reaction product Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 4
- 239000002352 surface water Substances 0.000 description 4
- JZCCFEFSEZPSOG-UHFFFAOYSA-L copper(II) sulfate pentahydrate Chemical compound O.O.O.O.O.[Cu+2].[O-]S([O-])(=O)=O JZCCFEFSEZPSOG-UHFFFAOYSA-L 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 235000004279 alanine Nutrition 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 2
- 239000013522 chelant Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 2
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 239000010981 turquoise Substances 0.000 description 2
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
- 238000004279 X-ray Guinier Methods 0.000 description 1
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
- 239000000292 calcium oxide Substances 0.000 description 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- JYYOBHFYCIDXHH-UHFFFAOYSA-N carbonic acid;hydrate Chemical compound O.OC(O)=O JYYOBHFYCIDXHH-UHFFFAOYSA-N 0.000 description 1
- 230000009920 chelation Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000005595 deprotonation Effects 0.000 description 1
- 238000010537 deprotonation reaction Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229910052732 germanium Inorganic materials 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 150000004698 iron complex Chemical class 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000004137 mechanical activation Methods 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- UOURRHZRLGCVDA-UHFFFAOYSA-D pentazinc;dicarbonate;hexahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Zn+2].[Zn+2].[Zn+2].[Zn+2].[Zn+2].[O-]C([O-])=O.[O-]C([O-])=O UOURRHZRLGCVDA-UHFFFAOYSA-D 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 239000011667 zinc carbonate Substances 0.000 description 1
- 229910000010 zinc carbonate Inorganic materials 0.000 description 1
- 235000004416 zinc carbonate Nutrition 0.000 description 1
- 229940118149 zinc sulfate monohydrate Drugs 0.000 description 1
- RNZCSKGULNFAMC-UHFFFAOYSA-L zinc;hydrogen sulfate;hydroxide Chemical compound O.[Zn+2].[O-]S([O-])(=O)=O RNZCSKGULNFAMC-UHFFFAOYSA-L 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/30—Copper compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/315—Zinc compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/76—Metal complexes of amino carboxylic acids
Definitions
- the invention relates to a process for the preparation of a composition containing at least one metal-amino acid compound, a composition obtainable by such a process and the use of such a composition.
- metal cations are vital to organisms because they fulfill important functions in proteins and other molecules. A sufficient uptake of the metal cations is therefore essential.
- the dosage form of Me tall cations when taken orally is crucial for the effectiveness of the acquisition on.
- the metal cations are usually administered in the form of metal-amino acid compounds, since the metal cations in this form are better absorbed by organisms.
- US 2,877,253 describes a therapeutic iron complex prepared from iron (II) sulfate and glycine.
- the amino acid glycine remains in its neutral form and the complex contains both the iron (II) cation and the sulfate anion.
- iron (II) sulfate and glycine are reacted in a molar ratio of 1: 1 in an aqueous environment at 70 ° C. and the reaction product is dried in vacuo.
- EP 1 453 845 B1 describes similarly prepared metal-amino acid complexes in which a Me tallsulfat is reacted with glycine in an aqueous environment and the Re action product is then dried by vacuum drying and adjusted to a specific degree of hydration.
- An advantage of such compounds is that they can be made in almost any metal to amino acid ratio who can, since the amino acid as a neutral ligand does not have to provide a necessary charge balance. This allows the economy of the amino acid complex to be well adjusted.
- the metal-amino acid complexes are all highly soluble in water and thus allow flexible application. However, these are not actual chelates.
- US 20140037960 A1 describes the preparation of metal amino acid chelates in which a basic compound of a divalent metal with glycine in stoichio metric ratio of 1: 2 is reacted without addition of water. Because it creates a metal amino acid chelate that should be free of byproducts. The problem of low reactivity of the basic compounds of divalent metals is counteracted by a prior mechanical activation in which the metal compounds are ground into very small particles. A disadvantage of the metal amino acid chelates prepared in this way is that the products have a poorer water solubility than simple amino acid complexes and, moreover, that the metal to amino acid ratio of 1: 2 is uneconomical with respect to the metal amino acid ratio of 1: 1 in the simple amino acid complexes. The basic compounds of divalent metals would also have to be mechanically activated by mills before Re start of action, which is associated with increased effort.
- the invention has for its object to provide a method for producing a composition containing at least one metal-amino acid compound, a composition obtainable by such a method, at de nen the above-mentioned disadvantages are reduced and the respective advantages remain th retained, as well as a Use of such a composition.
- the object is achieved by a method for producing a composition containing at least one metal-amino acid compound in which initially a basic compound of a divalent metal together is reacted with an alpha-amino acid in a molar ratio of 1 to at least 2 in water with heating to 60 ° C to 100 ° C, is waited until a reaction equilibrium has set, then the reaction solution with a water-soluble salt of the same bivalent metal in an amount ver is set, that the molar total amount of the bivalent metal of the basi's compound of the metal and the metal salt does not exceed the molar amount of the alpha-amino acid, is waited until the metal salt has completely dissolved and then the reaction solution under Obtaining a solid composition is dried.
- the overall reaction essentially takes place in two steps.
- a basic compound of a divalent metal ie, a metal having the oxidation state + II, together with at least twice the molar amount of an alpha-amino acid in water is heated to 60 ° C to 100 ° C for reaction.
- the basic compound of the divalent metal dissolves first by deprotonation of the amino acid in the water and the thereby released divalent metal cation reacts at closing with two deprotonated amino acids to a metal amino acid bi-schelat.
- the Bischelat may partially fail during the reaction.
- the reaction may be completed when the basic compound of the metal completely dissolves in water in the presence of the amino acid or the dissolution of the basic metal compound stagnates, or as much as the basic metal compound dissolves new basic metal compound is produced as a backlash. In all three cases However, it is initially waited until a reaction equilibrium sets in, in which case it can also be that the reaction has ended completely.
- a water-soluble salt of the same divalent metal is added to the reaction solution in an amount such that the total molar amount of the divalent metal of the basic compound of the metal and the metal salt does not exceed the molar amount of the alpha-amino acid.
- the additional metal cations react with the existing metal amino acid bischelate to form one or more complexes.
- a solid composition is obtained which has a high crystalline content, in which the metal amino acid Bischelat has combined with the additional metal ions to a water-soluble product with low amino acid content and without verun cleaning by-products.
- the molar ratio of metal to amino acid can be adjusted to 1: 1.
- This ratio is particularly economical Lich because amino acids are more expensive compared to metal salts and therefore for a economic product, the proportion of amino acid in the composition is low to keep.
- at least one amino acid molecule should be present in the product per metal cation since this ensures the positive effect of the amino acid on the metal uptake by the organism.
- the product is readily soluble in water and the process does not give rise to any undesirable byproducts which would have to be removed from the composition in a complicated manner or which would remain distracting in the composition.
- the basic compound of the divalent metal is a hydroxide, carbonate, hydroxide carbonate or an oxide.
- the oxide Upon dissolution of the basic metal compounds, the oxide reacts to form water, the hydroxide to water, and the carbonate to carbonic acid, which escapes as carbon dioxide in the reaction.
- the use of the basic compounds ensures that the amino acid is deprotonated so that the desired chelates are formed.
- the divalent metal of copper, manganese, zinc or iron gebil det is in a preferred embodiment of the inven tion sulfate.
- the alpha-amino acid is preferably a naturally occurring, proteinogenic amino acid, particularly preferred are glycine or alanine.
- the drying of the reaction solution takes place in a preferred embodiment of the invention in a spray granulator (spray granulation) by fluidized bed drying and more preferably at a product temperature of 70 to 130 ° C and / or in an oven, in a vacuum dryer and / or by spray drying.
- M divalent metal
- X eg OH
- R eg H-> glycine or CH 3 alanine
- the dark blue crystalline and granular composition (Figure 1) had a copper content of about 308 g / kg and a nitrogen content of about 83 g / kg and a surface water content of about 54 g / kg. It is characterized by an X-ray powder diffractogram ( Figure 2), which for Cu-Kcn radiation at
- the dark blue crystalline and granular composition had a copper content of about 312 g / kg and a nitrogen content of about 84 g / kg and a surface water content of about 12.2 g / kg. It is characterized by an X-ray powder diffractogram, which for Cu-Kcn radiation at room temperature particularly characteristic reflections at 10.29, 1 1, 67, 13,27, 14,84, 16,32, 19,15, 20,23 , 22,29, 23,76, 27,47, 28,01, 29,12, 31, 47 and 33,42 in 2Q.
- the dark blue crystalline and granular composition had a copper content of about 306 g / kg and a nitrogen content of about 84.6 g / kg and a surface water content of about 32 g / kg. It is characterized by an X-ray powder diffractogram, which for Cu-Kcn radiation at room temperature particularly characteristic reflections at 10.54, 1 1, 83, 13.27, 15.95, 16.42, 19.10, 20.27 , 22,34, 23,83, 27,52, 28,12, 29,23, 31, 59, 33,39 in 2Q.
- the detector used was an Imageplate IP-PSD from the company Stoe & Cie. None of the aforementioned compositions or compounds of this composition are included in the relevant crystal structure databases such as the Cambridge Structural Database (CSD).
- CSD Cambridge Structural Database
- the white crystalline composition has a zinc content of about 308 g / kg, a nitrogen content of about 69 g / kg and a surface water content of less than 5 g / kg. It is characterized by an X-ray powder diffractogram, wel particularly characteristic reflections at room temperature for Cu-Ka-i radiation at 7.58, 10.21, 11, 67, 15, 14, 16, 18, 17, 53, 18, 39, 18, 81, 20, 54, 20, 81, 21, 27 and 21, has 72 ° in 2Q ( Figure 3).
- Such a composition or compound is also not included in the relevant crystal structure databases such as the Cambridge Structural Database (CSD). It is here a reaction cascade ver mutated, which runs analogous to the above-mentioned reaction cascade with basic copper carbonate.
- CSD Cambridge Structural Database
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2020142000A RU2764579C1 (ru) | 2018-06-04 | 2019-04-23 | Способ получения композиции, содержащей по меньшей мере одно соединение металла с аминокислотой, а также композиция, получаемая этим способом |
BR112020023609-8A BR112020023609A2 (pt) | 2018-06-04 | 2019-04-23 | processo para preparar uma composição compreendendo pelo menos um composto de metal de aminoácido e composição que pode ser obtida por um processo deste tipo |
US17/059,275 US20210227851A1 (en) | 2018-06-04 | 2019-04-23 | Method for Producing a Composition Containing at Least one Metal Amino Acid Compound and Composition Obtainable by Means of a Method of this Kind |
EP19723329.9A EP3801492A1 (de) | 2018-06-04 | 2019-04-23 | Verfahren zur herstellung einer zusammensetzung enthaltend zumindest eine metall-aminosäure-verbindung sowie zusammensetzung erhältlich durch ein derartiges verfahren |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102018113243.3 | 2018-06-04 | ||
DE102018113243.3A DE102018113243A1 (de) | 2018-06-04 | 2018-06-04 | Verfahren zur Herstellung einer Zusammensetzung enthaltend zumindest eine Metall-Aminosäure-Verbindung sowie Zusammensetzung erhältlich durch ein derartiges Verfahren |
Publications (1)
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WO2019233671A1 true WO2019233671A1 (de) | 2019-12-12 |
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PCT/EP2019/060351 WO2019233671A1 (de) | 2018-06-04 | 2019-04-23 | Verfahren zur herstellung einer zusammensetzung enthaltend zumindest eine metall-aminosäure-verbindung sowie zusammensetzung erhältlich durch ein derartiges verfahren |
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US (1) | US20210227851A1 (de) |
EP (1) | EP3801492A1 (de) |
BR (1) | BR112020023609A2 (de) |
DE (1) | DE102018113243A1 (de) |
RU (1) | RU2764579C1 (de) |
WO (1) | WO2019233671A1 (de) |
Citations (8)
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US2877253A (en) | 1955-08-08 | 1959-03-10 | Schwarz Arzneimittelfabrik G M | Therapeutic iron complex |
US2957806A (en) * | 1959-01-06 | 1960-10-25 | Schwarz Arzneimittelfabrik G M | Process for raising blood serum iron levels and controlling anemia |
US4183947A (en) * | 1977-01-13 | 1980-01-15 | Cockerill Vernon | Nutritional and therapeutic iron composition and method of making |
US6458981B1 (en) | 2000-10-11 | 2002-10-01 | Albion International, Inc. | Composition and method for preparing amino acid chelate hydroxides free of interfering ions |
US6710079B1 (en) * | 2000-10-11 | 2004-03-23 | Albion International, Inc. | Composition and method for preparing amino acid chelates and complexes free of interfering complex ions |
EP1453845A2 (de) | 2001-11-21 | 2004-09-08 | Aradigm Corporation | Zusammensetzungen von nukleinsäuren und kationischen aminoglycosiden und verfahren zu deren verwendung und herstellung |
US20060128799A1 (en) * | 2002-12-05 | 2006-06-15 | Myung-Gyu Park | Method for preparation of amino acid chelate |
US20140037960A1 (en) | 2011-02-17 | 2014-02-06 | Isf Gmbh | Method for Producing Amino Acid Chelate Compounds, Amino Acid Chelate Compounds and Use of Amino Acid Chelate Compounds |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
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US4830716B1 (en) * | 1986-07-03 | 1999-12-07 | Albion Int | Preparation of pharmaceutical grade amino acid chelates |
US6407138B1 (en) * | 2000-10-11 | 2002-06-18 | Albion International, Inc. | Composition and method for preparing electrically neutral amino acid chelates free of interfering ions |
ES2222106B1 (es) * | 2003-07-11 | 2006-04-01 | Norel, S.A. | Procedimiento de produccion de carboxilatos metalicos y su uso como promotores de crecimiento en alimentacion animal. |
FR2935383B1 (fr) * | 2008-08-26 | 2010-10-01 | Pancosma Sa Pour L Ind Des Pro | Procede et dispositif pour la fabrication de complexes organometalliques en poudre. |
CN101503415A (zh) * | 2009-03-10 | 2009-08-12 | 深圳市危险废物处理站有限公司 | 氨基酸螯合羟基氯化铜结晶的制备方法及用途 |
MX342989B (es) * | 2009-10-30 | 2016-10-20 | Akzo Nobel Chemicals Int Bv | Uso de un suplemento de metal en alimento para animales. |
-
2018
- 2018-06-04 DE DE102018113243.3A patent/DE102018113243A1/de active Pending
-
2019
- 2019-04-23 US US17/059,275 patent/US20210227851A1/en active Pending
- 2019-04-23 RU RU2020142000A patent/RU2764579C1/ru active
- 2019-04-23 BR BR112020023609-8A patent/BR112020023609A2/pt unknown
- 2019-04-23 EP EP19723329.9A patent/EP3801492A1/de active Pending
- 2019-04-23 WO PCT/EP2019/060351 patent/WO2019233671A1/de unknown
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2877253A (en) | 1955-08-08 | 1959-03-10 | Schwarz Arzneimittelfabrik G M | Therapeutic iron complex |
US2957806A (en) * | 1959-01-06 | 1960-10-25 | Schwarz Arzneimittelfabrik G M | Process for raising blood serum iron levels and controlling anemia |
US4183947A (en) * | 1977-01-13 | 1980-01-15 | Cockerill Vernon | Nutritional and therapeutic iron composition and method of making |
US6458981B1 (en) | 2000-10-11 | 2002-10-01 | Albion International, Inc. | Composition and method for preparing amino acid chelate hydroxides free of interfering ions |
US6710079B1 (en) * | 2000-10-11 | 2004-03-23 | Albion International, Inc. | Composition and method for preparing amino acid chelates and complexes free of interfering complex ions |
EP1453845A2 (de) | 2001-11-21 | 2004-09-08 | Aradigm Corporation | Zusammensetzungen von nukleinsäuren und kationischen aminoglycosiden und verfahren zu deren verwendung und herstellung |
US20060128799A1 (en) * | 2002-12-05 | 2006-06-15 | Myung-Gyu Park | Method for preparation of amino acid chelate |
US20140037960A1 (en) | 2011-02-17 | 2014-02-06 | Isf Gmbh | Method for Producing Amino Acid Chelate Compounds, Amino Acid Chelate Compounds and Use of Amino Acid Chelate Compounds |
Also Published As
Publication number | Publication date |
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RU2764579C1 (ru) | 2022-01-18 |
BR112020023609A2 (pt) | 2021-02-17 |
US20210227851A1 (en) | 2021-07-29 |
DE102018113243A1 (de) | 2019-12-05 |
EP3801492A1 (de) | 2021-04-14 |
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