WO2019159884A1 - 認知症の検出のためのキット又はデバイス及び方法 - Google Patents

認知症の検出のためのキット又はデバイス及び方法 Download PDF

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Publication number
WO2019159884A1
WO2019159884A1 PCT/JP2019/004832 JP2019004832W WO2019159884A1 WO 2019159884 A1 WO2019159884 A1 WO 2019159884A1 JP 2019004832 W JP2019004832 W JP 2019004832W WO 2019159884 A1 WO2019159884 A1 WO 2019159884A1
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Prior art keywords
mir
hsa
polynucleotide
seq
gene
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PCT/JP2019/004832
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English (en)
French (fr)
Japanese (ja)
Inventor
佳奈 鈴木
真紀子 吉本
淳平 河内
裕子 須藤
悠歩 木田
聡子 小園
近藤　哲司
俊平 新飯田
裕也 浅海
大智 重水
孝 櫻井
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National Center for Geriatrics and Gerontology
Toray Industries Inc
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National Center for Geriatrics and Gerontology
Toray Industries Inc
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Priority to KR1020207022584A priority Critical patent/KR20200120627A/ko
Priority to EP24217565.1A priority patent/EP4498086A3/en
Priority to EP25205653.6A priority patent/EP4697021A2/en
Priority to CA3091211A priority patent/CA3091211A1/en
Priority to EP23216032.5A priority patent/EP4328587A3/en
Priority to CN201980013178.0A priority patent/CN111742060A/zh
Priority to EP19754972.8A priority patent/EP3754019B1/en
Priority to JP2020500479A priority patent/JP7414237B2/ja
Application filed by National Center for Geriatrics and Gerontology, Toray Industries Inc filed Critical National Center for Geriatrics and Gerontology
Priority to US16/969,328 priority patent/US12529104B2/en
Publication of WO2019159884A1 publication Critical patent/WO2019159884A1/ja
Anticipated expiration legal-status Critical
Priority to JP2023214501A priority patent/JP2024037978A/ja
Priority to JP2025152479A priority patent/JP2025186374A/ja
Priority to US19/419,995 priority patent/US20260117305A1/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Definitions

  • the present invention relates to a kit or device for detecting dementia comprising a nucleic acid capable of specifically binding to a specific miRNA or a complementary strand thereof, which is used for examining the presence or absence of dementia in a subject, and
  • the present invention relates to a method for detecting dementia, which includes measuring the expression level of miRNA.
  • the cost of medical care and care for patients with dementia will be ⁇ 14.500 billion in 2014 (breakdown: medical expenses ⁇ 1.9 trillion (hospitalization ⁇ 9703 billion, outpatient ⁇ 941.2 billion), nursing care costs 6 It has been reported that the amount has risen to 4 trillion yen (about 3,58.1 billion yen at home, about 2,916 billion yen for facilities) and informal care cost 6,200 billion yen (Ministry of Health, Labor and Welfare, Research Team “ Estimated social cost of dementia, May 2015). Worldwide, the number of patients with dementia will increase to 74.7 million by 2030, and the cost of medical care for dementia will be as high as 240 trillion yen (ADI “World Alzheimer Report 2015”). Dementia is generally progressive and involves irreversible degeneration of brain neurons. In order to reduce the burden on patients and caregivers and social costs at present when there are no drugs for the treatment of dementia, it is important to examine and diagnose dementia and to provide early medical intervention to suppress progression.
  • dementia is diagnosed by differential diagnosis such as medical history, current symptoms, physical findings, neuropsychological tests, blood tests, and imaging tests.
  • MMSE Mini-Mental State Test
  • the blood test recommended in the Dementia Diagnostic Disease Guidelines is necessary for excluding internal diseases that cause dementia and dementia-like symptoms in the diagnosis of degenerative dementia such as Alzheimer-type dementia.
  • degenerative dementia such as Alzheimer-type dementia.
  • Low cerebrospinal fluid (CSF) cerebral spinal fluid amyloid protein concentration and high tau concentration in Alzheimer type dementia are being utilized as surrogate markers, but there is a problem of high patient invasiveness.
  • CSF cerebrospinal fluid
  • MCI mild cognitive dysfunction
  • MiR-483-5p miRNA-483-5p
  • miR-486-5p miR-30b-5p
  • miR-200a-3p miR-502-3p
  • miR-142-3p miRNA-142-3p
  • MCI mild cognitive dysfunction
  • a dementia marker search was attempted by ingesting supplements that alleviate dementia symptoms in subjects with mild dementia, and comparing serum miRNA expression before and after ingestion.
  • Patent Document 2 reports that this antisense strand increases levels of nerve growth factor BDNF and IGF-1 and regenerates synapses in Alzheimer's disease model mice, and reports that this marker was also applicable to diagnosis. Yes.
  • Alzheimer's disease is measured by measuring the miRNA expression levels of 67 species (hsa-miR-1296, hsa-miR-424 *, hsa-miR-424, hsa-miR-629, etc.) in the specimen There is a report that this can be diagnosed (Patent Document 3).
  • Patent document 5 aims at the treatment and prevention of Alzheimer's disease and neurofibrillary degeneration due to abnormal tau expression, and the therapeutic purpose obtained as a result of searching for miRNA that binds to the 3′UTR of tau mRNA and controls tau expression. It is reported that markers (miR-185-5p, miR-151-5p, etc.) were applicable to diagnosis.
  • Patent Document 7 relates to cancer, inflammatory diseases, and dementia in body fluids including blood, serum, and plasma as an example of detection for the purpose of developing a microfluidic device that hybridizes and detects microRNA. It is reported that microRNA was detected.
  • dementia may have many disease types.
  • the result of pathological diagnosis was Alzheimer's dementia. Only 14 (3.13%) included 366 (81.88%) who had vascular dementia and Lewy body dementia in addition to Alzheimer's dementia.
  • Non-Patent Document 2 a dementia different from Alzheimer type dementia such as vascular dementia, Lewy body dementia, hippocampal atrophy.
  • JP 2017-184642 A US Patent Application Publication No. 2013/0184331 US Patent Application Publication No. 2014/0206777 US Patent Application Publication No. 2014/0120545 US Patent Application Publication No. 2017/0002348 International Publication No. 2017/084770 International Publication No. 2017/059094
  • Non-Patent Document 1 and Patent Documents 1 to 7 cannot be said to have sufficient performance as a marker for diagnosis of dementia as described below.
  • Non-Patent Document 1 only early-stage Alzheimer-type dementia and Alzheimer-type dementia included in mild dementia (MCI) are verified, and it is unclear whether dementia disease types other than Alzheimer-type dementia can be detected. is there.
  • Patent Document 1 only MCI, which is a stage before dementia, has been verified, and it is unknown whether dementia can be detected.
  • Patent Document 2 only Alzheimer model mice and human brain specimens have been verified, and there is no verification with blood specimens that can be collected with minimal invasiveness.
  • Patent Document 3 only Alzheimer type dementia is targeted, and it is unclear whether dementia disease types other than Alzheimer type dementia can be detected.
  • Patent Document 4 although MCI and a healthy person can be distinguished from MCI and Alzheimer's dementia, it is not possible to distinguish between a healthy person and Alzheimer's dementia.
  • Patent Document 5 only verification using a brain tissue is performed as an example, and it is unclear whether a blood sample can be detected in the same manner.
  • Patent Document 6 only whether or not the marker is expressed in the microglial cells of the model mouse has been verified, and it is unclear whether the marker can be detected using a human blood sample.
  • Patent Document 7 relates to a diagnostic device using microRNA in a body fluid, and dementia is exemplified together with cancer and inflammatory diseases. Although there is a description of detection of microRNA using specimens including blood, serum, and plasma, there is no example, and it is unclear whether the marker can be detected using human blood specimens.
  • cerebrospinal fluid as a sample for measurement is not preferable because it is highly invasive to patients and can be detected using a blood sample that can be collected in a minimally invasive manner.
  • a comprehensive dementia marker that can be used is desired. In particular, if the dementia can be detected without omission, the progression of dementia can be expected by medical intervention.
  • An object of the present invention is to provide a dementia marker capable of diagnosing one or more dementia disease types capable of distinguishing between dementia and normal cognitive function (non-dementia), and a nucleic acid capable of specifically binding to the marker. It is to provide a method that can be used to objectively and effectively detect whether or not the disease is dementia. Specifically, 1. There is no difference between medical facilities and doctors. 2. Comprehensive detection of multiple types of dementia. 3. Sensitivity / specificity of dementia is high. An object of the present invention is to provide an inspection method that satisfies one or more, preferably all of the four points of low invasiveness.
  • the present inventors have selected one of Alzheimer type dementia, vascular dementia, Lewy body dementia, normal pressure hydrocephalus, frontotemporal lobar degeneration, and the like.
  • the present inventors have found a novel dementia marker that can detect dementia of the above-mentioned disease types, and have completed the present invention.
  • the present invention includes the following aspects. (1) Dementia markers miR-4274, miR-4272, miR-4728-5p, miR-4443, miR-4506, miR-6773-5p, miR-4662a-5p, miR-3184-3p, miR -4281, miR-320d, miR-6729-3p, miR-5192, miR-6683-5p, miR-1234-3p, miR-1233-3p, miR-4539, miR-3914, miR-4438-5p, miR -548 au-3p, miR-1539, miR-4720-3p, miR-365b-5p, miR-4486, miR-1227-5p, miR-4667-5p, miR-6088, miR-6820-5p, miR-4505 , MiR-548q, miR-4658, mi -450a-5p, miR-1260b, miR-3777-5p, miR-6777-3p
  • polynucleotide according to any one of the following (a) to (e): (A) a polynucleotide comprising the base sequence represented by any one of SEQ ID NOs: 1-210, 374, 1315-1350, and 1435-1448, or a base sequence in which u is t in the base sequence, variants thereof, A derivative, or a fragment thereof comprising 15 or more consecutive bases, (B) a polynucleotide comprising the base sequence represented by any of SEQ ID NOs: 1-210, 374, 1315-1350, and 1435-1448, (C) a polynucleotide comprising a base sequence represented by any one of SEQ ID NOs: 1-210, 374, 1315-1350 and 1435-1448 or a base sequence complementary to the base sequence in which u is t in the base sequence A variant thereof, a derivative thereof, or a fragment thereof comprising 15 or more consecutive bases, (D) a polynucleotide comprising the
  • the kit is another dementia marker, miR-1471, miR-1538, miR-449b-3p, miR-1976, miR-4268, miR-4279, miR-3620-3p, miR-3944 -3p, miR-3156-3p, miR-3187-5p, miR-4687-3p, miR-4695-3p, miR-4697-3p, miR-4713-5p, miR-4723-3p, miR-371b-3p MiR-3151-3p, miR-3192-3p, miR-6728-3p, miR-6736-3p, miR-6740-3p, miR-6741-3p, miR-6743-3p, miR-6747-3p, miR -6750-3p, miR-6754-3p, miR-6759-3p, m R-6761-3p, miR-6762-3p, miR-6769a-3p, miR-6766-3p, miR-6778-3p, miR-6679-3p, miR-6
  • polynucleotide according to any one of the following (p) to (t): (P) comprising a polynucleotide comprising the base sequence represented by any of SEQ ID NOs: 375 to 390 or a base sequence in which u is t in the base sequence, a variant thereof, a derivative thereof, or 15 or more consecutive bases Its fragments, (Q) a polynucleotide comprising the base sequence represented by any of SEQ ID NOs: 375 to 390, (R) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 375 to 390 or a nucleotide sequence complementary to a nucleotide sequence in which u is t in the nucleotide sequence, a variant thereof, a derivative thereof, or 15 or more A fragment thereof containing a continuous base of (S) a nucleotide sequence represented by any of SEQ ID NOs: 375 to 390 or
  • kits for detecting or predicting dementia further comprising one or more polynucleotides selected from the above, or a nucleic acid II capable of specifically binding to a complementary strand of the polynucleotide.
  • polynucleotide according to any one of the following (u) to (y): (U) any of SEQ ID NOs: 3, 8, 15, 26, 34, 40, 53, 69, 99, 101, 107, 109, 112, 125, 128, 133, 191 to 194, 212, and 250 to 374
  • a polynucleotide comprising the nucleotide sequence represented by or a nucleotide sequence wherein u is t in the nucleotide sequence, a variant thereof, a derivative thereof, or a fragment thereof comprising 15 or more consecutive bases, (V) any of SEQ ID NOs: 3, 8, 15, 26, 34, 40, 53, 69, 99, 101, 107, 109, 112, 125, 128, 133, 191 to 194, 212, and 250 to 374 (W) SEQ ID NOs: 3, 8, 15, 26, 34, 40, 53, 69, 99, 101, 107, 109, 112, 125, 128, 133, 191 to A polynu
  • the device is another dementia marker, miR-1471, miR-1538, miR-449b-3p, miR-1976, miR-4268, miR-4279, miR-3620-3p, miR-3944 -3p, miR-3156-3p, miR-3187-5p, miR-4687-3p, miR-4695-3p, miR-4697-3p, miR-4713-5p, miR-4723-3p, miR-371b-3p MiR-3151-3p, miR-3192-3p, miR-6728-3p, miR-6736-3p, miR-6740-3p, miR-6741-3p, miR-6743-3p, miR-6747-3p, miR -6750-3p, miR-6754-3p, miR-6759-3p miR-6676-3p, miR-6762-3p, miR-6769a-3p, miR-6766-3p, miR-6778-3p, miR-6679-3p, miR-6786-3
  • the device according to any one of (16) The polynucleotide according to any one of the following (k) to (o): (K) including a polynucleotide comprising the nucleotide sequence represented by any of SEQ ID NOs: 250 to 373 or a nucleotide sequence in which u is t in the nucleotide sequence, a variant thereof, a derivative thereof, or 15 or more consecutive bases Its fragments, (L) a polynucleotide comprising the base sequence represented by any of SEQ ID NOs: 250 to 373, (m) the base sequence represented by any of SEQ ID NOs: 250 to 373 or a base in which u is t in the base sequence A polynucleotide comprising a base sequence complementary to the sequence, a variant thereof, a derivative thereof, or a fragment thereof containing 15 or more consecutive bases, (N) a polynucleotide comprising a nucleotide sequence represented by any of SEQ ID NO
  • a device for detecting or predicting dementia which further comprises one or more polynucleotides selected from the above, or a nucleic acid II that can specifically bind to a complementary strand of the polynucleotide.
  • polynucleotide according to any one of the following (u) to (y): (U) any of SEQ ID NOs: 3, 8, 15, 26, 34, 40, 53, 69, 99, 101, 107, 109, 112, 125, 128, 133, 191 to 194, 212, and 250 to 374
  • a polynucleotide comprising the nucleotide sequence represented by or a nucleotide sequence wherein u is t in the nucleotide sequence, a variant thereof, a derivative thereof, or a fragment thereof comprising 15 or more consecutive bases, (V) any of SEQ ID NOs: 3, 8, 15, 26, 34, 40, 53, 69, 99, 101, 107, 109, 112, 125, 128, 133, 191 to 194, 212, and 250 to 374 (W) SEQ ID NOs: 3, 8, 15, 26, 34, 40, 53, 69, 99, 101, 107, 109, 112, 125, 128, 133, 191 to A polynu
  • the expression level of the polynucleotide is measured using a nucleic acid that can specifically bind to the polynucleotide or a complementary strand of the polynucleotide, and the nucleic acid is any of the following (a) to (e): Polynucleotides shown in: (A) a polynucleotide comprising the base sequence represented by any one of SEQ ID NOS: 1-210, 374, 1315-1350, and 1435-1448, or the base sequence in which u is t in the base sequence, or a variant thereof A derivative thereof, or a fragment thereof comprising 15 or more consecutive bases, (B) a polynucleotide comprising the base sequence represented by any of SEQ ID NOs: 1-210, 374, 1315-1350, and 1435-1448, (C) Comprising a base sequence complementary to the base sequence represented by any of SEQ ID NOS: 1-210, 374, 1315-1350, and 1435-1448, or
  • the expression level of the polynucleotide is measured using a nucleic acid that can specifically bind to the polynucleotide or a complementary strand of the polynucleotide, and the nucleic acid is any of the following (f) to (j): Polynucleotides shown in: (F) a polynucleotide comprising the base sequence represented by any of SEQ ID NOs: 211 to 249, 1351 to 1356, and 1449 to 1453, or the base sequence in which u is t in the base sequence, a variant thereof, A derivative, or a fragment thereof comprising 15 or more consecutive bases, (G) a polynucleotide comprising the base sequence represented by any of SEQ ID NOs: 211 to 249, 1351 to 1356, and 1449 to 1453, (H) a polynucleotide comprising a base sequence complementary to the base sequence represented by any one of SEQ ID NOs: 211 to 249, 1351 to 13
  • the expression level of the polynucleotide is measured using a nucleic acid capable of specifically binding to the polynucleotide or a complementary strand of the polynucleotide, and the nucleic acid is any of the following (k) to (o) Polynucleotides shown in: (K) including a polynucleotide comprising the nucleotide sequence represented by any of SEQ ID NOs: 250 to 373 or a nucleotide sequence in which u is t in the nucleotide sequence, a variant thereof, a derivative thereof, or 15 or more consecutive bases Its fragments, (L) a polynucleotide comprising the base sequence represented by any of SEQ ID NOs: 250 to 373, (m) the base sequence represented by any of SEQ ID NOs: 250 to 373 or a base in which u is t in the base sequence A polynucleotide comprising a base sequence complementary to the sequence, a variant thereof, a
  • the expression level of the polynucleotide is measured using a nucleic acid capable of specifically binding to the polynucleotide or a complementary strand of the polynucleotide, and the nucleic acid is any of the following (p) to (t) Polynucleotides shown in: (P) comprising a polynucleotide comprising the base sequence represented by any of SEQ ID NOs: 375 to 390 or a base sequence in which u is t in the base sequence, a variant thereof, a derivative thereof, or 15 or more consecutive bases Its fragments, (Q) a polynucleotide comprising the base sequence represented by any of SEQ ID NOs: 375 to 390, (R) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 375 to 390 or a nucleotide sequence complementary to a nucleotide sequence in which u is t in the nucleot
  • MiR-532-3p, miR-877-3p, miR-1238-3p, miR-3130-5p, miR-4298, miR-4290, miR-3943, miR-346, and miR-767-3p Measuring the expression level of one or more polynucleotides II selected from Using the measured expression level to assess in vitro whether or not the subject suffers from dementia, or predict the likelihood that the subject will suffer from dementia or in vitro Dementia detection or prediction method.
  • the expression level of the polynucleotide I is measured using a nucleic acid that can specifically bind to the polynucleotide I or a complementary strand of the polynucleotide, and the nucleic acid is represented by the following (u) to (y):
  • a polynucleotide comprising the nucleotide sequence represented by or a nucleotide sequence wherein u is t in the nucleotide sequence, a variant thereof, a derivative thereof, or a fragment thereof comprising 15 or more consecutive bases, (V) any of SEQ ID NOs: 3, 8, 15, 26, 34, 40, 53, 69, 99, 101, 107, 109, 112, 125, 128,
  • polynucleotide according to any one of the following (a) to (e): (A) a polynucleotide comprising the nucleotide sequence represented by any one of SEQ ID NOS: 194 to 210, 374, and 1315 to 1350, or a nucleotide sequence in which u is t in the nucleotide sequence, a variant thereof, a derivative thereof, or 15 Its fragments containing the above consecutive bases, (B) a polynucleotide comprising the base sequence represented by any of SEQ ID NOs: 194 to 210, 374, and 1315 to 1350, (C) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 194 to 210, 374, and 1315 to 1350, or a nucleotide sequence complementary to a nucleotide sequence in which u is t in the nucleotide sequence, or a variant thereof
  • polynucleotide according to any one of the following (f) to (j): (F) a polynucleotide comprising the base sequence represented by any of SEQ ID NOs: 211 to 212 and 1351-1356, or a base sequence in which u is t in the base sequence, a variant thereof, a derivative thereof, or 15 or more Its fragments containing consecutive bases, (G) a polynucleotide comprising the base sequence represented by any of SEQ ID NOs: 211-212 and 1351-1356, (H) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 211 to 212 and 1351-1356, or a nucleotide sequence complementary to a nucleotide sequence in which u is t in the nucleotide sequence, a variant thereof, A derivative, or a fragment thereof comprising 15 or more consecutive bases, (I) a polynucleotide comprising
  • the polynucleotide wherein the nucleic acid is represented by any of the following (f) to (j):
  • a method for detecting dementia in a subject comprising substituting the expression level of a target gene in a specimen derived from the subject, thereby evaluating dementia or non-dementia.
  • the polynucleotide according to any one of the following (a) to (e): (A) a polynucleotide comprising the nucleotide sequence represented by any one of SEQ ID NOS: 194 to 210, 374, and 1315 to 1350, or a nucleotide sequence in which u is t in the nucleotide sequence, a variant thereof, a derivative thereof, or 15 Its fragments containing the above consecutive bases, (B) a polynucleotide comprising the base sequence represented by any of SEQ ID NOs: 194 to 210, 374, and 1315 to 1350, (C) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 194 to 210, 374,
  • the disease type of dementia is Alzheimer type dementia, vascular dementia, Lewy body dementia, normal pressure hydrocephalus. , Frontotemporal lobar degeneration, neurofibrillary tangle dementia, dementia caused by diseases such as infectious diseases, dementia such as alcoholic dementia or vitamin deficiency dementia, or any mixture of these Type or dementia of unknown or unspecified disease type.
  • the dementia marker miR-4274 is hsa-miR-4274, and miR-4272 is hsa-miR-. 4272, miR-4728-5p is hsa-miR-4728-5p, miR-4443 is hsa-miR-4443, miR-4506 is hsa-miR-4506, and miR-6773-5p is hsa-miR-6773-5p, miR-4662a-5p is hsa-miR-4662a-5p, miR-3184-3p is hsa-miR-3184-3p, and miR-4281 is hsa-miR- 4281, miR-320d is hsa-miR-320d, miR 6729-3p is hsa-miR-6729-3p, miR-5192 is hsa-miR
  • miR-6810-5p is hsa-miR-6810-5p
  • miR-6823-3p is hsa-miR-6823-3p
  • miR-6825-3p is hsa-miR-6825- 3R
  • miR-6629-3p is hsa-miR-6829-3p
  • miR-6683-3p is hsa-miR-6833-3p
  • miR-6683-3p is hsa-miR-6683-3p.
  • MiR-6780b-3p is hsa-miR-6780b-3p
  • miR-6845-3p is hsa-miR-6845-3p
  • miR-6862-3p is hsa-miR-6862-3p
  • miR-6865-3p is hsa-miR-6865-3p
  • miR-6870-3p is sa-miR-6870-3p
  • miR-6875-3p is hsa-miR-6875-3p
  • miR-6877-3p is hsa-miR-6877-3p
  • miR-6879-3p is hsa- miR-6879-3p
  • miR-6882-3p is hsa-miR-6882-3p
  • miR-6885-3p is hsa-miR-6885-3p
  • miR-6886-3p is hsa-miR- 686-3p
  • the dementia marker miR-6765-3p is hsa-miR-6765-3p, and miR-6784.
  • 5p is hsa-miR-6784-5p
  • miR-5698 is hsa-miR-5698
  • miR-6778-5p is hsa-miR-6778-5p
  • miR-1915-3p is hsa-miR- 1915-3p
  • miR-6875-5p is hsa-miR-6875-5p
  • miR-1343-5p is hsa-miR-1343-5p
  • miR-4534 is hsa-miR-4534
  • miR-6861-5p is hsa-miR-6861-5p and miR-4721 is hs -MiR-4721
  • miR-6756-5p is hsa-miR-6756-5p
  • polynucleotide is used for nucleic acids including RNA, DNA, and RNA / DNA (chimera).
  • the DNA includes any of cDNA, genomic DNA, and synthetic DNA.
  • the RNA includes total RNA, mRNA, rRNA, miRNA, siRNA, snoRNA, snRNA, non-coding RNA, and synthetic RNA.
  • synthetic DNA and “synthetic RNA” are artificially generated using, for example, an automatic nucleic acid synthesizer based on a predetermined base sequence (which may be either a natural sequence or a non-natural sequence). It refers to the prepared DNA and RNA.
  • non-natural sequence is intended to be used in a broad sense, and is a sequence (for example, one or more nucleotide substitutions, deletions, insertions and / or additions) that differs from the natural sequence ( That is, it includes a mutant sequence), a sequence containing one or more modified nucleotides (ie, a modified sequence), and the like.
  • the polynucleotide is used interchangeably with the nucleic acid.
  • a “fragment” is a polynucleotide having a base sequence of a continuous part of a polynucleotide, and desirably has a length of 15 bases or more, preferably 17 bases or more, more preferably 19 bases or more. .
  • RNA and double-stranded DNA include not only RNA and double-stranded DNA, but also each single-stranded DNA such as positive strand (or sense strand) or complementary strand (or antisense strand) constituting the same. It is intended to be used.
  • the length is not particularly limited.
  • “gene” refers to double-stranded DNA including human genomic DNA, single-stranded DNA (positive strand), and single-stranded DNA having a sequence complementary to the positive strand (complementary). Strand), cDNA, microRNA (miRNA), and fragments thereof, the human genome, and transcripts thereof.
  • the “gene” is not limited to a “gene” represented by a specific nucleotide sequence (or sequence number), but also RNAs having biological functions equivalent to RNA encoded by these, for example, homologs (ie, homologs). Or an ortholog), variants such as genetic polymorphisms, and “nucleic acids” encoding derivatives.
  • nucleic acid encoding such homologue, variant or derivative includes, under stringent conditions described later, SEQ ID NOS: 1-1314, 1315-1434, and 1435-1505 (for example, the sequence 194 to 212, 374, 398, 490, 591, 593 to 609, 766, 1015 to 1017, 1019 to 1024, 1026 to 1031, 1285 to 1286, and 1315 to 1434)
  • SEQ ID NOS: 1-1314, 1315-1434, and 1435-1505 for example, the sequence 194 to 212, 374, 398, 490, 591, 593 to 609, 766, 1015 to 1017, 1019 to 1024, 1026 to 1031, 1285 to 1286, and 1315 to 1434
  • a “nucleic acid” having a base sequence that hybridizes with a complementary sequence of the base sequence in which u is t in the base sequence can be mentioned.
  • the “gene” does not ask whether the functional region is different, and may include, for example, an expression control region, a coding region, an exon, or an intron. Further, the “gene” may be contained in the cell, may be released outside the cell and may be present alone, or may be encapsulated in a vesicle called an exosome.
  • exosome or “exosome” is a vesicle encapsulated in a lipid bilayer secreted from a cell. Exosomes are derived from multivesicular endosomes, and when released to the extracellular environment, they may contain biological substances such as “genes” such as RNA and DNA and proteins. It is known that exosomes are contained in body fluids such as blood, serum, plasma and lymph.
  • RNA refers to RNA synthesized using a DNA sequence of a gene as a template.
  • RNA is synthesized in such a manner that RNA polymerase binds to a site called a promoter located upstream of the gene and ribonucleotides are bound to the 3 'end so as to be complementary to the DNA base sequence.
  • This RNA includes not only the gene itself but also the entire sequence from the transcription start point to the end of the poly A sequence, including the expression control region, coding region, exon or intron.
  • microRNA is a protein complex that is transcribed as a hairpin-like RNA precursor, cleaved by a dsRNA cleaving enzyme having RNase III cleaving activity, and called RISC. 15-25 base non-coding RNA that is incorporated into and is involved in the translational repression of mRNA.
  • miRNA used herein includes not only “miRNA” represented by a specific base sequence (or sequence number) but also a precursor of the “miRNA” (pre-miRNA, pri-miRNA).
  • miRNAs that are biologically equivalent to the miRNAs encoded by them, such as homologues (ie, homologs or orthologs), variants such as genetic polymorphisms, and derivatives that encode derivatives.
  • homologues ie, homologs or orthologs
  • variants such as genetic polymorphisms
  • derivatives that encode derivatives.
  • the “miRNA” encoding such precursor, homologue, mutant or derivative can be specifically identified by “miRBase” (version 21), and can be sequenced under stringent conditions described later.
  • MiRNA having a base sequence that hybridizes with a complementary sequence of any one of the specific base sequences.
  • MiRBBase version 21 is a database on the Web that provides miRNA base sequences, annotations, target gene predictions, and the like (http://www.mirbase.org/).
  • miRNAs registered in “miRBase” are limited to those that have been cloned or that have been shown to be expressed and processed in vivo.
  • the “miRNA” used herein may be a gene product of a miR gene, and such a gene product is a mature miRNA (for example, 15 to 25 involved in the suppression of translation of mRNA as described above. Bases, or 19-25 bases of non-coding RNA) or miRNA precursors (eg, pre-miRNA or pri-miRNA as described above).
  • the “probe” includes a polynucleotide used for specifically detecting RNA produced by gene expression or a polynucleotide derived therefrom and / or a polynucleotide complementary thereto.
  • the “primer” includes a continuous polynucleotide and / or a complementary polynucleotide that specifically recognizes and amplifies RNA generated by gene expression or a polynucleotide derived therefrom.
  • complementary polynucleotide refers to SEQ ID NOs: 1 to 1314, 1315 to 1434, and 1435 to 1505 (for example, SEQ ID NOs: 194 to 212, 374, 398, 490, 591).
  • the base sequence is complementary to the full-length sequence of the polynucleotide or a partial sequence thereof (referred to herein as the positive strand for convenience) based on the base pair relationship such as A: T (U), G: C. It refers to a related polynucleotide.
  • complementary strand is not limited to the case where it forms a completely complementary sequence with the target positive strand base sequence, but has a complementary relationship that allows it to hybridize with the target positive strand under stringent conditions. It may be.
  • stringent conditions means a nucleic acid probe that is detectable to a greater extent than other sequences (eg, average of background measurements + standard error of background measurements ⁇ measured value of 2 or more). ) And the conditions for hybridizing to the target sequence. Stringent conditions are sequence-dependent and depend on the environment in which hybridization is performed. By controlling the stringency of the hybridization and / or wash conditions, target sequences that are 100% complementary to the nucleic acid probe can be identified. Specific examples of “stringent conditions” will be described later.
  • the “Tm value” means a temperature at which a double-stranded portion of a polynucleotide is denatured into a single strand and the double strand and the single strand are present at a ratio of 1: 1.
  • variant refers to a natural variant caused by polymorphism, mutation, or the like, or a base sequence represented by a sequence number or a base in which u is t in the base sequence.
  • a variant comprising a deletion, substitution, addition or insertion of 1, 2 or 3 or more (eg 1 to several) bases in the sequence, or a partial sequence thereof, or SEQ ID NOs: 1-210, 211-249, 250 To 374, 375 to 390, 1315 to 1350, 1351 to 1356, 1435 to 1448, and 1449 to 1453, the base sequence of the precursor RNA (premature miRNA), or u in the base sequence
  • a mutant comprising a deletion, substitution, addition or insertion of one or more bases in a certain base sequence or a partial sequence thereof, or A variant showing% identity of about 90% or more, about 95% or more, about 97% or more, about 98% or more, about 99% or more with each base sequence or a partial sequence thereof, or the base sequence or
  • “several” means an integer of about 10, 9, 8, 7, 6, 5, 4, 3 or 2.
  • a mutant can be prepared using a well-known technique such as site-directed mutagenesis or PCR-based mutagenesis.
  • % identity is based on BLAST (https://blast.ncbi.nlm.nih.gov/Blast.cgi) and FASTA (http://www.genome.jp/tools/fasta/). It can be determined using a protein or gene search system, with or without introducing a gap (Zheng Zhang et al., 2000, J. Comput. Biol., 7, p203-214; Altschul, SF, et al., 1990, Journal of Molecular Biology, Vol. 215, p403-410; Pearson, WR, et al., 1988, Proc. Natl. Acad. Sci. U.S.A., 85 , P2444-2448).
  • the term “derivative” refers to a modified nucleic acid, a non-limiting group such as a labeled derivative such as a fluorophore, a modified nucleotide (for example, a halogen, an alkyl such as methyl, an alkoxy such as methoxy, a group such as thio, carboxymethyl, etc. , Derivatives including PNA (peptide nucleic acid; Nielsen, PE, etc.). 1991, Science, 254, p1497-500), LNA (locked nucleic acid; Obika, S. et al., 1998, Tetrahedron Lett., 39, p5401-5404) and the like.
  • PNA peptide nucleic acid
  • LNA locked nucleic acid
  • a polynucleotide selected from the above-mentioned dementia marker miRNA, or a “nucleic acid” capable of specifically binding to a complementary strand of the polynucleotide is a synthesized or prepared nucleic acid, specifically Contains a “nucleic acid probe” or “primer” to detect the presence or absence of dementia in a subject, or the presence or absence of dementia, the degree of illness, the presence or absence of dementia improvement, or the degree of improvement It is used directly or indirectly for diagnosing susceptibility to treatment of dementia, or for screening candidate substances useful for prevention, amelioration or treatment of dementia.
  • SEQ ID NOs: 1 to 1314 and 1315 to 1434, and 1435 to 1505 (for example, SEQ ID NOs: 194 to 212, 374, etc.) in vivo, particularly in specimens such as body fluids such as blood and urine in connection with the onset of dementia 398, 490, 591, 593-609, 766, 1015-1017, 1019-1024, 1026-1031, 1285-1286, and 1315-1434), or a cDNA synthesized nucleic acid thereof, or these Nucleotides, oligonucleotides and polynucleotides capable of specifically recognizing and binding the complementary strand of These nucleotides, oligonucleotides and polynucleotides are used as probes for detecting the gene expressed in vivo, in tissues or cells based on the above properties, and for amplifying the gene expressed in vivo. It can be effectively used as a primer.
  • the term “detection” can be replaced by the term inspection, measurement, detection or decision support. Further, in this specification, the term “evaluation” is used in a meaning including supporting diagnosis or evaluation based on a test result or a measurement result.
  • subject includes humans, primates including chimpanzees, pet animals such as dogs and cats, livestock animals such as cows, horses, sheep and goats, rodents such as mice and rats, Mammals such as animals raised in zoos.
  • a preferred subject is a human.
  • a “normal cognitive person” also means an animal that is such a mammal and does not suffer from the dementia to be detected.
  • a preferred normal cognitive person is a human.
  • ementia refers to a condition in which cognitive function that has once been normal has been sustainedly reduced due to an acquired brain disorder. In general, the diagnosis is made when there is a decrease in function to the extent that it interferes with daily life and social life.
  • Dementia is generally classified into disease types such as Alzheimer type dementia, vascular dementia, Lewy body dementia, normal pressure hydrocephalus, frontotemporal lobar degeneration, etc., depending on the causative disease.
  • “dementia” includes Alzheimer-type dementia, vascular dementia, Lewy body dementia, normal pressure hydrocephalus, frontotemporal lobar degeneration, neurofibrillary tangle dementia, other Dementia such as dementia, alcoholic dementia, vitamin deficiency dementia caused by disease (infection etc.) is included.
  • “dementia” in the present invention includes dementia that is a mixed type of any of these disease types.
  • dementia whose disease type is unknown or unspecified is also included in the “dementia” in the present invention.
  • Alzheimer's-type dementia is a core symptom of cognitive memory impairment due to atrophy of the medial temporal lobe without abnormal brain structures in CT, MRI, and PET imaging tests. Is a dementia with approximate memory impairment.
  • vascular dementia appears in connection with cerebrovascular disorders, and cognitive memory disorders are heterogeneous or patchy and have a decline in memory and intellectual ability. Dementia that is relatively well maintained.
  • Lewy body dementia refers to a decrease in dopamine transporter uptake in the basal ganglia by cerebral blood flow SPECT or PET imaging. This is a dementia with parkinsonism, hallucinations that repeatedly appear.
  • normal pressure hydrocephalus is a dementia in which cerebrospinal fluid accumulates in the ventricle and compresses the surrounding brain, resulting in cognitive impairment, gait disturbance, and dysuria. Dementia that can be improved by surgical treatment.
  • frontotemporal lobar degeneration is a dementia that exhibits language impairment and psychiatric symptoms due to significant atrophy of the frontal and temporal lobes.
  • P or “P value” refers to the probability that, in a statistical test, a statistic more extreme than the statistic actually calculated from the data under the null hypothesis is observed. Indicates. Therefore, it can be considered that the smaller the “P” or “P value”, the more significant the difference between the comparison objects.
  • sensitivity means a value of (number of true positives) / (number of true positives + number of false negatives). If the sensitivity is high, dementia can be detected early, and early medical intervention is possible.
  • specificity means (number of true negatives) / (number of true negatives + number of false positives). If the specificity is high, it is possible to prevent a person with normal cognitive function from being misidentified as a patient with dementia and to carry out a wasteful additional test, thereby reducing the burden on the patient and medical costs.
  • accuracy means a value of (number of true positives + number of true negatives) / (number of all cases). The accuracy indicates the rate at which the discrimination results for all the samples are correct, and is a first index for evaluating the detection performance.
  • the “specimen” to be determined, detected or diagnosed is a tissue or living body in which the gene of the present invention changes in expression as a result of the occurrence of dementia, the progression of dementia, and the exertion of a therapeutic effect on dementia.
  • material Specifically, brain tissue and nerve cells, nerve tissue, cerebrospinal fluid, bone marrow fluid, organs, skin, and body fluids such as blood, urine, saliva, sweat, tissue exudate, serum prepared from blood, plasma, etc.
  • the biological sample extracted from these specifically refers to genes such as RNA and miRNA.
  • hsa-miR-4274 gene or “hsa-miR-4274” refers to the hsa-miR-4274 gene (miRBase Accession No. MIMAT0016906) described in SEQ ID NO: 1 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-4274 gene was obtained from Goff LA et al., 2009, PLoS One. 4, Volume 4, e7192.
  • hsa-miR-4274 “hsa-mir-4274” (miRBase Accession No. MI0015884, SEQ ID NO: 391), which has a hairpin-like structure as a precursor, is known.
  • hsa-miR-4272 gene or “hsa-miR-4272” refers to the hsa-miR-4272 gene (miRBase Accession No. MIMAT0016902) described in SEQ ID NO: 2 and other biological species. Homologs or orthologs are included. The hsa-miR-4272 gene was found in Goff LA et al., 2009, PLoS One. 4, Volume 4, e7192. As for “hsa-miR-4272”, “hsa-mir-4272” (miRBase Accession No. MI0015880, SEQ ID NO: 392) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4728-5p gene or “hsa-miR-4728-5p” refers to the hsa-miR-4728-5p gene described in SEQ ID NO: 3 (miRBase Accession No. MIMAT0019849) and other species homologues or orthologues are included.
  • the hsa-miR-4728-5p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4728-5p “hsa-mir-4728” (miRBase Accession No. MI0017365, SEQ ID NO: 393) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4443 gene or “hsa-miR-4443” refers to the hsa-miR-4443 gene (miRBase Accession No. MIMAT0018961) described in SEQ ID NO: 4 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-4443 gene is described in Jim DD et al., 2010, Blood. 116, e118-e127.
  • hsa-miR-4443 is known as “hsa-mir-4443” (miRBase Accession No. MI0016786, SEQ ID NO: 394) having a hairpin-like structure as a precursor.
  • hsa-miR-4506 gene or “hsa-miR-4506” refers to the hsa-miR-4506 gene (miRBase Accession No. MIMAT0019042) described in SEQ ID NO: 5 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-4506 gene can be found in Jim DD et al., 2010, Blood. 116, e118-e127.
  • “Hsa-miR-4506” is known as “hsa-mir-4506” (miRBase Accession No. MI0016869, SEQ ID NO: 395), which has a hairpin-like structure as a precursor.
  • hsa-miR-6773-5p gene or “hsa-miR-6773-5p” refers to the hsa-miR-6773-5p gene described in SEQ ID NO: 6 (miRBase Accession No. MIMAT0027446) and other species homologues or orthologues are included.
  • the hsa-miR-6773-5p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6773-5p “hsa-mir-6773” (miRBase Accession No. MI0022618, SEQ ID NO: 396) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4662a-5p gene or “hsa-miR-4662a-5p” refers to the hsa-miR-4662a-5p gene described in SEQ ID NO: 7 (miRBase Accession No. MIMAT0019731) and other species homologues or orthologues are included.
  • the hsa-miR-4662a-5p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4661a-5p “hsa-mir-4662a” (miRBase Accession No. MI0017290, SEQ ID NO: 397) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3184-3p gene or “hsa-miR-3184-3p” refers to the hsa-miR-3184-3p gene described in SEQ ID NO: 8 (miRBase Accession No. MIMAT0022731) and other species homologues or orthologues are included.
  • the hsa-miR-3184-3p gene was obtained from Stark MS et al., 2010, PLoS One. No. 5, vol. E9685.
  • “hsa-miR-3184-3p” is known as “hsa-mir-3184” (miRBase Accession No. MI0014226, SEQ ID NO: 398) having a hairpin-like structure as a precursor.
  • hsa-miR-4281 gene or “hsa-miR-4281” refers to the hsa-miR-4281 gene (miRBase Accession No. MIMAT0016907) described in SEQ ID NO: 9 or other biological species. Homologs or orthologs are included. The hsa-miR-4281 gene was found in Goff LA et al., 2009, PLoS One. 4, Volume 4, e7192. As for “hsa-miR-4281”, “hsa-mir-4281” (miRBase Accession No. MI0015885, SEQ ID NO: 399) having a hairpin-like structure as a precursor is known.
  • hsa-miR-320d gene or “hsa-miR-320d” refers to the hsa-miR-320d gene (miRBase Accession No. MIMAT0006764) described in SEQ ID NO: 10 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-320d gene is described in Friedlander MR et al., 2008, Nat Biotechnol. 26, 407-415.
  • “hsa-miR-320d” has a hairpin-like structure as its precursor, “hsa-mir-320d-1, hsa-mir-320d-2” (miRBase Accession No. MI0008190, MI0008192, SEQ ID NO: 400, 401) is known.
  • hsa-miR-6729-3p gene or “hsa-miR-6729-3p” refers to the hsa-miR-6729-3p gene described in SEQ ID NO: 11 (miRBase Accession No. MIMAT0027360) and other species homologs or orthologs.
  • the hsa-miR-6729-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6729-3p “hsa-mir-6729” (miRBase Accession No. MI0022574, SEQ ID NO: 402) having a hairpin-like structure as a precursor is known.
  • hsa-miR-5192 gene or “hsa-miR-5192” refers to the hsa-miR-5192 gene (miRBase Accession No. MIMAT0021123) described in SEQ ID NO: 12 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-5192 gene was obtained from Schotte et al., 2011, Leukemia. 25, 1389-1399.
  • hsa-miR-5192 “hsa-mir-5192” (miRBase Accession No. MI0018171, SEQ ID NO: 403) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6683-5p gene or “hsa-miR-6833-5p” refers to the hsa-miR-6683-5p gene (miRBase Accession No. 6) described in SEQ ID NO: 13. MIMAT0027606) and other species homologues or orthologues are included.
  • the hsa-miR-6683-5p gene was obtained from Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6833-5p” is known as “hsa-mir-6853” (miRBase Accession No. MI0022699, SEQ ID NO: 404) having a hairpin-like structure as a precursor.
  • hsa-miR-1234-3p gene or “hsa-miR-1234-3p” refers to the hsa-miR-1234-3p gene described in SEQ ID NO: 14 (miRBase Accession No. MIMAT0005589) and other species homologues or orthologues are included.
  • the hsa-miR-1234-3p gene was obtained from Berezikov E et al., 2007, Mol Cell. 28, 328-336.
  • hsa-mir-1234 (miRBase Accession No. MI0006324, SEQ ID NO: 405) having a hairpin-like structure as a precursor is known.
  • hsa-miR-1233-3p gene or “hsa-miR-1233-3p” refers to the hsa-miR-1233-3p gene described in SEQ ID NO: 15 (miRBase Accession No. MIMAT0005588) and other species homologues or orthologues are included.
  • the hsa-miR-1233-3p gene was obtained from Berezikov E et al., 2007, Mol Cell. 28, 328-336.
  • “hsa-miR-1233-3p” has “hsa-mir-1233-1, hsa-mir-12233-2” (miRBase Accession No. MI0006323, MI0015973, SEQ ID NO :) having a hairpin-like structure as a precursor. 406, 407) are known.
  • hsa-miR-4539 gene or “hsa-miR-4539” refers to the hsa-miR-4539 gene (miRBase Accession No. MIMAT0019082) described in SEQ ID NO: 16 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-4539 gene is disclosed in Jim DD et al., 2010, Blood. 116, e118-e127.
  • hsa-mir-4539 (miRBase Accession No. MI0016910, SEQ ID NO: 408) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3914 gene or “hsa-miR-3914” refers to the hsa-miR-3914 gene (miRBase Accession No. MIMAT0018188) described in SEQ ID NO: 17 and other biological species. Homologs or orthologs are included. The hsa-miR-3914 gene was found in Creighton CJ et al., 2010, PLoS One. 5, Vol. 5, e9637.
  • “Hsa-miR-3914” has a hairpin-like structure as a precursor thereof, “hsa-mir-3914-1, hsa-mir-3914-2” (miRBase Accession No. MI0016419, MI0016421, SEQ ID NO: 409, 410) is known.
  • hsa-miR-4738-5p gene or “hsa-miR-4738-5p” refers to the hsa-miR-4738-5p gene described in SEQ ID NO: 18 (miRBase Accession No. MIMAT0019866) and other species homologs or orthologs.
  • the hsa-miR-4738-5p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4738-5p “hsa-mir-4738” (miRBase Accession No. MI0017376, SEQ ID NO: 411) having a hairpin-like structure as a precursor is known.
  • hsa-miR-548au-3p gene or “hsa-miR-548au-3p” refers to the hsa-miR-548au-3p gene described in SEQ ID NO: 19 (miRBase Accession No. 1). MIMAT0022292) and other species homologues or orthologues are included.
  • the hsa-miR-548au-3p gene was found in Friedlander MR et al., 2012, Nucleic Acids Res. 40, 37-52.
  • “hsa-miR-548au-3p” is known as “hsa-mir-548au” (miRBase Accession No. MI0019145, SEQ ID NO: 412) having a hairpin-like structure as a precursor.
  • hsa-miR-1539 gene or “hsa-miR-1539” refers to the hsa-miR-1539 gene (miRBase Accession No. MIMAT0007401) described in SEQ ID NO: 20 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-1539 gene was obtained from Azuma-Mukai A et al., 2008, Proc Natl Acad Sci US A. 105, 7964-7969.
  • hsa-miR-1539 is known as “hsa-mir-1539” (miRBase Accession No. MI0007260, SEQ ID NO: 413) having a hairpin-like structure as a precursor.
  • hsa-miR-4720-3p gene or “hsa-miR-4720-3p” refers to the hsa-miR-4720-3p gene described in SEQ ID NO: 21 (miRBase Accession No. MIMAT0019834) and other species homologues or orthologues are included.
  • the hsa-miR-4720-3p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • “hsa-miR-4720-3p” is known as “hsa-mir-4720” (miRBase Accession No. MI0017355, SEQ ID NO: 414) having a hairpin-like structure as a precursor.
  • hsa-miR-365b-5p gene or “hsa-miR-365b-5p” refers to the hsa-miR-365b-5p gene described in SEQ ID NO: 22 (miRBase Accession No. MIMAT0022833) and other species homologs or orthologs.
  • the hsa-miR-365b-5p gene is described in Xie X et al., 2005, Nature. 434, 338-345.
  • hsa-miR-365b-5p “hsa-mir-365b” (miRBase Accession No. MI000069, SEQ ID NO: 415) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4486 gene or “hsa-miR-4486” refers to the hsa-miR-4486 gene (miRBase Accession No. MIMAT0019020) described in SEQ ID NO: 23 and other biological species. Homologs or orthologs are included. The hsa-miR-4486 gene was found in Jim DD et al., 2010, Blood. 116, e118-e127. As for “hsa-miR-4486”, “hsa-mir-4486” (miRBase Accession No. MI0016847, SEQ ID NO: 416) having a hairpin-like structure as a precursor is known.
  • hsa-miR-1227-5p gene or “hsa-miR-1227-5p” refers to the hsa-miR-1227-5p gene described in SEQ ID NO: 24 (miRBase Accession No. MIMAT0022941) and other species homologues or orthologues are included.
  • the hsa-miR-1227-5p gene was obtained from Berezikov E et al., 2007, Mol Cell. 28, 328-336.
  • “hsa-miR-1227-5p” is known as “hsa-mir-1227” (miRBase Accession No. MI0006316, SEQ ID NO: 417) having a hairpin-like structure as a precursor.
  • hsa-miR-4667-5p gene or “hsa-miR-4667-5p” refers to the hsa-miR-4667-5p gene described in SEQ ID NO: 25 (miRBase Accession No. MIMAT0019743) and other species homologues or orthologues are included.
  • the hsa-miR-4667-5p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4667-5p “hsa-mir-4667” (miRBase Accession No. MI0017297, SEQ ID NO: 418) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6088 gene or “hsa-miR-6088” refers to the hsa-miR-6088 gene (miRBase Accession No. MIMAT0023713) described in SEQ ID NO: 26 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-6088 gene was obtained from Yoo JK et al., 2012, Stem Cells Dev. 21, 2049-2057.
  • hsa-miR-6088 “hsa-mir-6088” (miRBase Accession No. MI0020365, SEQ ID NO: 419) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6820-5p gene or “hsa-miR-6820-5p” refers to the hsa-miR-6820-5p gene described in SEQ ID NO: 27 (miRBase Accession No. MIMAT0027540) and other species homologs or orthologs.
  • the hsa-miR-6820-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6820-5p” is known as “hsa-mir-6820” (miRBase Accession No. MI0022665, SEQ ID NO: 420) having a hairpin-like structure as a precursor.
  • hsa-miR-4505 gene or “hsa-miR-4505” refers to the hsa-miR-4505 gene (miRBase Accession No. MIMAT0019041) described in SEQ ID NO: 28 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-4505 gene is disclosed in Jim DD et al., 2010, Blood. 116, e118-e127.
  • “Hsa-miR-4505” is known as “hsa-mir-4505” (miRBase Accession No. MI0016868, SEQ ID NO: 421) having a hairpin-like structure as a precursor.
  • hsa-miR-548q gene or “hsa-miR-548q” refers to the hsa-miR-548q gene (miRBase Accession No. MIMAT0011163) described in SEQ ID NO: 29 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-548q gene was obtained from Wyman SK et al., 2009, PLoS One. 4, Volume 4, e5311.
  • hsa-miR-548q “hsa-mir-548q” (miRBase Accession No. MI0010637, SEQ ID NO: 422) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4658 gene or “hsa-miR-4658” refers to the hsa-miR-4658 gene (miRBase Accession No. MIMAT0019725) described in SEQ ID NO: 30 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-4658 gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4658 “hsa-mir-4658” (miRBase Accession No. MI0017286, SEQ ID NO: 423) having a hairpin-like structure as a precursor is known.
  • hsa-miR-450a-5p gene or “hsa-miR-450a-5p” refers to the hsa-miR-450a-5p gene described in SEQ ID NO: 31 (miRBase Accession No. MIMAT001545) and other species homologs or orthologs.
  • the hsa-miR-450a-5p gene is described in Xie X et al., 2005, Nature. 434, 338-345.
  • “Hsa-miR-450a-5p” has a hairpin-like structure as its precursor, “hsa-mir-450a-1, hsa-mir-450a-2” (miRBase Accession No. MI0001652, MI0003187, SEQ ID NO: 424, 425) is known.
  • hsa-miR-1260b gene or “hsa-miR-1260b” refers to the hsa-miR-1260b gene (miRBase Accession No. MIMAT0015041) described in SEQ ID NO: 32 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-1260b gene was obtained from Stark MS et al., 2010, PLoS One. No. 5, vol. E9685.
  • hsa-miR-1260b “hsa-mir-1260b” (miRBase Accession No. MI0014197, SEQ ID NO: 426) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3777-5p gene or “hsa-miR-3777-5p” refers to the hsa-miR-3777-5p gene described in SEQ ID NO: 33 (miRBase Accession No. MIMAT0019221) and other species homologues or orthologues are included.
  • the hsa-miR-3777-5p gene was obtained from Vaz C et al., 2010, BMC Genomics. 11 and 288.
  • hsa-miR-3777-5p “hsa-mir-3677” (miRBase Accession No. MI0016078, SEQ ID NO: 427) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6777-3p gene or “hsa-miR-6777-3p” refers to the hsa-miR-6777-3p gene described in SEQ ID NO: 34 (miRBase Accession No. MIMAT0027455) and other species homologs or orthologs.
  • the hsa-miR-6777-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6777-3p” is known as “hsa-mir-6777” (miRBase Accession No. MI0022622, SEQ ID NO: 428) having a hairpin-like structure as a precursor.
  • hsa-miR-6826-3p gene or “hsa-miR-6826-3p” refers to the hsa-miR-6826-3p gene described in SEQ ID NO: 35 (miRBase Accession No. MIMAT0027553) and other species homologs or orthologs.
  • the hsa-miR-6826-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6826-3p” is known as “hsa-mir-6826” (miRBase Accession No. MI0022671, SEQ ID NO: 429) having a hairpin-like structure as a precursor.
  • hsa-miR-6832-p gene or “hsa-miR-6832-p” refer to the hsa-miR-6832-p gene (miRBase Accession No. 36) described in SEQ ID NO: 36. MIMAT0027565) and other species homologs or orthologs.
  • the hsa-miR-6832-p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “Hsa-miR-6832-p” is known as “hsa-mir-6632” (miRBase Accession No. MI0022677, SEQ ID NO: 430) having a hairpin-like structure as a precursor.
  • hsa-miR-4725-3p gene or “hsa-miR-4725-3p” refers to the hsa-miR-4725-3p gene described in SEQ ID NO: 37 (miRBase Accession No. MIMAT0019844) and other species homologs or orthologs.
  • the hsa-miR-4725-3p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4725-3p “hsa-mir-4725” (miRBase Accession No. MI0017362, SEQ ID NO: 431) having a hairpin-like structure as a precursor is known.
  • hsa-miR-7161-3p gene or “hsa-miR-7161-3p” refers to the hsa-miR-7161-3p gene described in SEQ ID NO: 38 (miRBase Accession No. MIMAT0028233) and other species homologs or orthologs.
  • the hsa-miR-7161-3p gene is described in Meunier J et al., 2013, Genome Res. 23, 34-45.
  • “hsa-miR-7161-3p” is known as “hsa-mir-7161” (miRBase Accession No. MI0023619, SEQ ID NO: 432) having a hairpin-like structure as a precursor.
  • hsa-miR-2277-5p gene or “hsa-miR-2277-5p” refers to the hsa-miR-2277-5p gene (miRBase Accession No. MIMAT0017352) and other species homologues or orthologues are included.
  • the hsa-miR-2277-5p gene was obtained from Nygaard S et al., 2009, BMC Med Genomics. 2 and 35.
  • “hsa-miR-2277-5p” is known as “hsa-mir-2277” (miRBase Accession No. MI0011284, SEQ ID NO: 433) having a hairpin-like structure as a precursor.
  • hsa-miR-7110-3p gene or “hsa-miR-7110-3p” refers to the hsa-miR-7110-3p gene described in SEQ ID NO: 40 (miRBase Accession No. MIMAT0028118) and other species homologs or orthologs are included.
  • the hsa-miR-7110-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-7110-3p” is known as “hsa-mir-7110” (miRBase Accession No. MI0022961, SEQ ID NO: 434) having a hairpin-like structure as a precursor.
  • hsa-miR-4312 gene or “hsa-miR-4312” refers to the hsa-miR-4312 gene (miRBase Accession No. MIMAT0016864) described in SEQ ID NO: 41 or other species. Homologs or orthologs are included. The hsa-miR-4312 gene was found in Goff LA et al., 2009, PLoS One. 4, Volume 4, e7192. As for “hsa-miR-4312”, “hsa-mir-4312” (miRBase Accession No. MI0015842, SEQ ID NO: 435) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4461 gene or “hsa-miR-4461” refers to the hsa-miR-4461 gene (miRBase Accession No. MIMAT0018983) described in SEQ ID NO: 42 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-4461 gene is disclosed in Jim DD et al., 2010, Blood. 116, e118-e127.
  • hsa-mir-4461 (miRBase Accession No. MI0016807, SEQ ID NO: 436) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6766-5p gene or “hsa-miR-6766-5p” refers to the hsa-miR-6766-5p gene described in SEQ ID NO: 43 (miRBase Accession No. MIMAT0027432) and other species homologues or orthologues are included.
  • the hsa-miR-6766-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6766-5p” is known as “hsa-mir-6766” (miRBase Accession No. MI0022611, SEQ ID NO: 437) having a hairpin-like structure as a precursor.
  • hsa-miR-1266-3p gene or “hsa-miR-1266-3p” refers to the hsa-miR-1266-3p gene described in SEQ ID NO: 44 (miRBase Accession No. MIMAT0026742) and other species homologues or orthologues are included.
  • the hsa-miR-1266-3p gene is described in Morin RD et al., 2008, Genome Res. 18, 610-621.
  • “Hsa-miR-1266-3p” is known as “hsa-mir-1266” (miRBase Accession No. MI0006403, SEQ ID NO: 438) having a hairpin-like structure as a precursor.
  • hsa-miR-6729-5p gene or “hsa-miR-6729-5p” refers to the hsa-miR-6729-5p gene described in SEQ ID NO: 45 (miRBase Accession No. MIMAT0027359) and other species homologues or orthologues are included.
  • the hsa-miR-6729-5p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6729-5p” is known as “hsa-mir-6729” (miRBase Accession No. MI0022574, SEQ ID NO: 402) having a hairpin-like structure as a precursor.
  • hsa-miR-526b-3p gene or “hsa-miR-526b-3p” refers to the hsa-miR-526b-3p gene described in SEQ ID NO: 46 (miRBase Accession No. MIMAT0002836) and other species homologues or orthologues are included.
  • the hsa-miR-526b-3p gene was obtained from Bentwich I et al., 2005, Nat Genet. 37, 766-770.
  • hsa-miR-526b-3p “hsa-mir-526b” (miRBase Accession No. MI0003150, SEQ ID NO: 439) having a hairpin-like structure as a precursor is known.
  • hsa-miR-519e-5p gene or “hsa-miR-519e-5p” refers to the hsa-miR-519e-5p gene described in SEQ ID NO: 47 (miRBase Accession No. MIMAT0002828) and other species homologs or orthologs.
  • the hsa-miR-519e-5p gene was obtained from Bentwich I et al., 2005, Nat Genet. 37, 766-770.
  • hsa-miR-519e-5p “hsa-mir-519e” (miRBase Accession No. MI0003145, SEQ ID NO: 440) having a hairpin-like structure as a precursor is known.
  • hsa-miR-512-5p gene or “hsa-miR-512-5p” refers to the hsa-miR-512-5p gene described in SEQ ID NO: 48 (miRBase Accession No. MIMAT0002822) and other species homologs or orthologs are included.
  • the hsa-miR-512-5p gene was obtained from Bentwich I et al., 2005, Nat Genet. 37, 766-770.
  • “hsa-miR-512-5p” has “hsa-mir-512-1, hsa-mir-512-2” (miRBase Accession No. MI0003140, MI0003141, SEQ ID NO. 441, 442) are known.
  • hsa-miR-5088-5p gene or “hsa-miR-5088-5p” refers to the hsa-miR-5088-5p gene described in SEQ ID NO: 49 (miRBase Accession No. MIMAT0021080) and other species homologs or orthologs.
  • the hsa-miR-5088-5p gene is disclosed in Ding N et al., 2011, J Radiat Res. 52, 425-432.
  • “hsa-miR-5088-5p” is known as “hsa-mir-5088” (miRBase Accession No. MI0017977, SEQ ID NO: 443) having a hairpin-like structure as a precursor.
  • hsa-miR-1909-3p gene or “hsa-miR-1909-3p” refers to the hsa-miR-1909-3p gene described in SEQ ID NO: 50 (miRBase Accession No. MIMAT0007883) and other species homologs or orthologs.
  • the hsa-miR-1909-3p gene is described in Bar M et al., 2008, Stem Cells. 26, 2496-2505.
  • “Hsa-miR-1909-3p” is known as “hsa-mir-1909” (miRBase Accession No. MI0008330, SEQ ID NO: 444) having a hairpin-like structure as a precursor.
  • hsa-miR-6511a-5p gene or “hsa-miR-6511a-5p” refers to the hsa-miR-6511a-5p gene described in SEQ ID NO: 51 (miRBase Accession No. MIMAT0025478) and other species homologues or orthologues are included.
  • the hsa-miR-6511a-5p gene was obtained from Joyce CE et al., 2011, Hum Mol Genet. 20, Vol. 4025-4040.
  • hsa-miR-6511a-5p has a hairpin-like structure as its precursor, “hsa-mir-6651a-1, hsa-mir-6511a-2, hsa-mir-6651a-3, hsa-mir”.
  • -6511a-4 "(miRBBase Accession No. MI0022223, MI0023564, MI0023565, MI0023566, SEQ ID NOs: 445, 446, 447, 448) are known.
  • hsa-miR-4734 gene or “hsa-miR-4734” refers to the hsa-miR-4734 gene (miRBase Accession No. MIMAT0019859) described in SEQ ID NO: 52 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-4734 gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4734 “hsa-mir-4734” (miRBase Accession No. MI0017371, SEQ ID NO: 449) having a hairpin-like structure as a precursor is known.
  • hsa-miR-936 gene or “hsa-miR-936” refers to the hsa-miR-936 gene (miRBase Accession No. MIMAT0004979) described in SEQ ID NO: 53 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-936 gene is disclosed in Lui WO et al., 2007, Cancer Res. 67, 6031-6043.
  • hsa-miR-936 “hsa-mir-936” (miRBase Accession No. MI0005758, SEQ ID NO: 450) having a hairpin-like structure as a precursor is known.
  • hsa-miR-1249-3p gene or “hsa-miR-1249-3p” refers to the hsa-miR-1249-3p gene described in SEQ ID NO: 54 (miRBase Accession No. MIMAT0005901) and other species homologues or orthologues are included.
  • the hsa-miR-1249-3p gene is described in Morin RD et al., 2008, Genome Res. 18, 610-621.
  • hsa-miR-1249-3p “hsa-mir-1249” (miRBase Accession No. MI0006384, SEQ ID NO: 451) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6777-5p gene or “hsa-miR-6777-5p” refers to the hsa-miR-6777-5p gene described in SEQ ID NO: 55 (miRBase Accession No. MIMAT0027454) and other species homologues or orthologues are included.
  • the hsa-miR-6777-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6777-5p “hsa-mir-6777” (miRBase Accession No. MI0022622, SEQ ID NO: 428) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4487 gene or “hsa-miR-4487” refers to the hsa-miR-4487 gene (miRBase Accession No. MIMAT0019021) described in SEQ ID NO: 56 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-4487 gene is disclosed in Jim DD et al., 2010, Blood. 116, e118-e127.
  • hsa-miR-4487 is known as “hsa-mir-4487” (miRBase Accession No. MI0016848, SEQ ID NO: 452) having a hairpin-like structure as a precursor.
  • hsa-miR-3155a gene or “hsa-miR-3155a” refers to the hsa-miR-3155a gene (miRBase Accession No. MIMAT0015029) described in SEQ ID NO: 57 and other biological species. Homologs or orthologs are included. The hsa-miR-3155a gene was obtained from Stark MS et al., 2010, PLoS One. No. 5, vol. E9685. As for “hsa-miR-3155a”, “hsa-mir-3155a” (miRBase Accession No. MI0014183, SEQ ID NO: 453) having a hairpin-like structure as a precursor is known.
  • hsa-miR-563 gene or “hsa-miR-563” refers to the hsa-miR-563 gene (miRBase Accession No. MIMAT0003227) described in SEQ ID NO: 58 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-563 gene was obtained from Cummins JM et al., 2006, Proc Natl Acad Sci USA. 103, 3687-3692.
  • “Hsa-miR-563” is known as “hsa-mir-563” (miRBase Accession No. MI0003569, SEQ ID NO: 454) having a hairpin-like structure as a precursor.
  • hsa-miR-4741 gene or “hsa-miR-4741” refers to the hsa-miR-4741 gene (miRBase Accession No. MIMAT0019871) described in SEQ ID NO: 59 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-4741 gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4741 “hsa-mir-4741” (miRBase Accession No. MI0017379, SEQ ID NO: 455) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6788-5p gene or “hsa-miR-6788-5p” refers to the hsa-miR-6788-5p gene described in SEQ ID NO: 60 (miRBase Accession No. MIMAT0027476) and other species homologs or orthologs.
  • the hsa-miR-6788-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6788-5p” is known as “hsa-mir-6788” (miRBase Accession No. MI0022633, SEQ ID NO: 456) having a hairpin-like structure as a precursor.
  • hsa-miR-4433b-5p gene or “hsa-miR-4433b-5p” refers to the hsa-miR-4433b-5p gene described in SEQ ID NO: 61 (miRBase Accession No. MIMAT0030413) and other species homologues or orthologues are included.
  • the hsa-miR-4433b-5p gene was found in Ple H et al., 2012, PLoS One. 7, Vol. 7, e50746.
  • hsa-miR-4433b-5p “hsa-mir-4433b” (miRBase Accession No. MI0025511, SEQ ID NO: 457) having a hairpin-like structure as a precursor is known.
  • hsa-miR-323a-5p gene or “hsa-miR-323a-5p” refers to the hsa-miR-323a-5p gene described in SEQ ID NO: 62 (miRBase Accession No. MIMAT0004696) and other species homologs or orthologs.
  • the hsa-miR-323a-5p gene was found in Kim J et al., 2004, Proc Natl Acad Sci USA. 101, 360-365.
  • “hsa-miR-323a-5p” “hsa-mir-323a” (miRBase Accession No. MI0000807, SEQ ID NO: 458) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6811-5p gene or “hsa-miR-6811-5p” refers to the hsa-miR-6811-5p gene described in SEQ ID NO: 63 (miRBase Accession No. MIMAT0027522) and other species homologs or orthologs.
  • the hsa-miR-6811-5p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6811-5p “hsa-mir-6811” (miRBase Accession No. MI0022656, SEQ ID NO: 459) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6721-5p gene or “hsa-miR-6721-5p” refers to the hsa-miR-6721-5p gene described in SEQ ID NO: 64 (miRBase Accession No. MIMAT0025852) and other species homologs or orthologs.
  • the hsa-miR-6721-5p gene is disclosed in Li Y et al., 2012, Gene. 497, 330-335.
  • hsa-miR-6721-5p “hsa-mir-6721” (miRBase Accession No. MI0022556, SEQ ID NO: 460) having a hairpin-like structure as a precursor is known.
  • hsa-miR-5004-5p gene or “hsa-miR-5004-5p” refers to the hsa-miR-5004-5p gene described in SEQ ID NO: 65 (miRBase Accession No. MIMAT0021027) and other species homologs or orthologs.
  • the hsa-miR-5004-5p gene was obtained from Hansen TB et al., 2011, RNA Biol. 8, 378-383.
  • hsa-miR-5004-5p “hsa-mir-5004” (miRBase Accession No. MI0017870, SEQ ID NO: 461) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6509-3p gene or “hsa-miR-6509-3p” refers to the hsa-miR-6509-3p gene described in SEQ ID NO: 66 (miRBase Accession No. MIMAT0025475) and other species homologues or orthologues are included.
  • the hsa-miR-6509-3p gene was obtained from Joyce CE et al., 2011, Hum Mol Genet. 20, Vol. 4025-4040.
  • “hsa-miR-6509-3p” is known as “hsa-mir-6509” (miRBase Accession No. MI0022221, SEQ ID NO: 462) having a hairpin-like structure as a precursor.
  • hsa-miR-648 gene or “hsa-miR-648” refers to the hsa-miR-648 gene (miRBase Accession No. MIMAT0003318) described in SEQ ID NO: 67 and other biological species. Homologs or orthologs are included. The hsa-miR-648 gene was found in Cummins JM et al., 2006, Proc Natl Acad Sci USA. 103, 3687-3692. As for “hsa-miR-648”, “hsa-mir-648” (miRBase Accession No. MI0003663, SEQ ID NO: 463) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3717 gene or “hsa-miR-3913” refers to the hsa-miR-3717 gene (miRBase Accession No. MIMAT0018191) described in SEQ ID NO: 68 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-3918 gene was obtained from Creighton CJ et al., 2010, PLoS One. 5, Vol. 5, e9637.
  • hsa-miR-3917 is known as “hsa-mir-3917” (miRBase Accession No. MI0016423, SEQ ID NO: 464) having a hairpin-like structure as a precursor.
  • hsa-miR-6087 gene or “hsa-miR-6087” refers to the hsa-miR-6087 gene (miRBase Accession No. MIMAT0023712) described in SEQ ID NO: 69 or other species. Homologs or orthologs are included.
  • the hsa-miR-6087 gene was obtained from Yoo JK et al., 2012, Stem Cells Dev. 21, 2049-2057.
  • hsa-miR-6087 “hsa-mir-6087” (miRBase Accession No. MI0020364, SEQ ID NO: 465) having a hairpin-like structure as a precursor is known.
  • hsa-miR-1470 gene or “hsa-miR-1470” refers to the hsa-miR-1470 gene (miRBase Accession No. MIMAT0007348) described in SEQ ID NO: 70 or other biological species. Homologs or orthologs are included. The hsa-miR-1470 gene was found in Kawaji H et al., 2008, BMC Genomics. , Vol. 9, 157. Also, “hsa-miR-1470” is known as “hsa-mir-1470” (miRBase Accession No. MI00000075, SEQ ID NO: 466) having a hairpin-like structure as a precursor.
  • hsa-miR-586 gene or “hsa-miR-586” refers to the hsa-miR-586 gene (miRBase Accession No. MIMAT0003252) described in SEQ ID NO: 71 or other biological species. A homolog or ortholog is included.
  • the hsa-miR-586 gene was obtained from Cummins JM et al., 2006, Proc Natl Acad Sci USA. 103, 3687-3692.
  • hsa-miR-586 “hsa-mir-586” (miRBase Accession No. MI0003594, SEQ ID NO: 467) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3150a-5p gene or “hsa-miR-3150a-5p” refers to the hsa-miR-3150a-5p gene described in SEQ ID NO: 72 (miRBase Accession No. MIMAT0019206) and other species homologs or orthologs.
  • the hsa-miR-3150a-5p gene was obtained from Stark MS et al., 2010, PLoS One. No. 5, vol. E9685.
  • “Hsa-miR-3150a-5p” is known as “hsa-mir-3150a” (miRBase Accession No. MI0014177, SEQ ID NO: 468) having a hairpin-like structure as a precursor.
  • hsa-miR-105-3p gene or “hsa-miR-105-3p” refers to the hsa-miR-105-3p gene described in SEQ ID NO: 73 (miRBase Accession No. MIMAT0004516) and other species homologues or orthologues are included.
  • the hsa-miR-105-3p gene is described in Mouretos Z et al., 2002, Genes Dev. 16, 720-728.
  • “hsa-miR-105-3p” has “hsa-mir-105-1, hsa-mir-105-2” (miRBBase Accession No. MI0000111, MI0000112, SEQ ID NO. 469, 470).
  • hsa-miR-7773 gene or “hsa-miR-7793” refers to the hsa-miR-7793 gene (miRBase Accession No. MIMAT0031176) described in SEQ ID NO: 74 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-797 gene was obtained from Velthut-Meikas A, et al., 2013, Endocrinol. 27, 1128-1141.
  • hsa-miR-7793 has a hairpin-like structure as a precursor thereof, “hsa-mir-7793-1, hsa-mir-7793-2” (miRBase Accession No. MI0025748, MI0025749, SEQ ID NO: 471, 472) is known.
  • hsa-miR-1914-5p gene or “hsa-miR-1914-5p” refers to the hsa-miR-1914-5p gene (miRBase Accession No. MIMAT0007889) and other species homologs or orthologs.
  • the hsa-miR-1914-5p gene is described in Bar M et al., 2008, Stem Cells. 26, 2496-2505.
  • “hsa-miR-1914-5p” is known as “hsa-mir-1914” (miRBase Accession No. MI0008335, SEQ ID NO: 473) having a hairpin-like structure as a precursor.
  • hsa-miR-4749-3p gene or “hsa-miR-4749-3p” refers to the hsa-miR-4749-3p gene described in SEQ ID NO: 76 (miRBase Accession No. MIMAT0019886) and other species homologues or orthologues are included.
  • the hsa-miR-4749-3p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • “hsa-miR-4749-3p” is known as “hsa-mir-4749” (miRBase Accession No. MI0017388, SEQ ID NO: 474) having a hairpin-like structure as a precursor.
  • hsa-miR-15b-5p gene or “hsa-miR-15b-5p” refers to the hsa-miR-15b-5p gene described in SEQ ID NO: 77 (miRBase Accession No. MIMAT000017) and other species homologues or orthologues are included.
  • the hsa-miR-15b-5p gene was obtained from Lagos-Quintana M et al., 2002, Curr Biol. 12, Vol. 735-739.
  • “hsa-miR-15b-5p” is known as “hsa-mir-15b” (miRBase Accession No. MI0000438, SEQ ID NO: 475) having a hairpin-like structure as a precursor.
  • hsa-miR-1289 gene or “hsa-miR-1289” refers to the hsa-miR-1289 gene (miRBase Accession No. MIMAT0005879) described in SEQ ID NO: 78 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-1289 gene is described in Morin RD et al., 2008, Genome Res. 18, 610-621.
  • “hsa-miR-1289” has “hsa-mir-1289-1, hsa-mir-1289-2” (miRBase Accession No. MI0006350, MI0006351, SEQ ID NO: 476, taking a hairpin-like structure as a precursor 477) is known.
  • hsa-miR-4433a-5p gene or “hsa-miR-4433a-5p” refers to the hsa-miR-4433a-5p gene described in SEQ ID NO: 79 (miRBase Accession No. MIMAT0020956) and other species homologues or orthologues are included.
  • the hsa-miR-4433a-5p gene is described in Jim DD et al., 2010, Blood. 116, e118-e127.
  • “hsa-miR-4433a-5p” is known as “hsa-mir-4433a” (miRBase Accession No. MI0016773, SEQ ID NO: 478) having a hairpin-like structure as a precursor.
  • hsa-miR-3666 gene or “hsa-miR-3666” refers to the hsa-miR-3666 gene (miRBase Accession No. MIMAT0018088) described in SEQ ID NO: 80 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-3666 gene is described in Xie X et al., 2005, Nature. 434, 338-345.
  • hsa-miR-3666 “hsa-mir-3666” (miRBase Accession No. MI0016067, SEQ ID NO: 479) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3186-3p gene or “hsa-miR-3186-3p” refers to the hsa-miR-3186-3p gene described in SEQ ID NO: 81 (miRBase Accession No. MIMAT0015068) and other species homologs or orthologs.
  • the hsa-miR-3186-3p gene was obtained from Creighton CJ et al., 2010, PLoS One. 5, Vol. 5, e9637.
  • “hsa-miR-3186-3p” is known as “hsa-mir-3186” (miRBase Accession No. MI0014229, SEQ ID NO: 480) having a hairpin-like structure as a precursor.
  • hsa-miR-4725-5p gene or “hsa-miR-4725-5p” refers to the hsa-miR-4725-5p gene described in SEQ ID NO: 82 (miRBase Accession No. MIMAT0019843) and other species homologs or orthologs.
  • the hsa-miR-4725-5p gene is described in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • “Hsa-miR-4725-5p” is known as “hsa-mir-4725” (miRBase Accession No. MI0017362, SEQ ID NO: 431) having a hairpin-like structure as a precursor.
  • hsa-miR-4488 gene or “hsa-miR-4488” refers to the hsa-miR-4488 gene (miRBase Accession No. MIMAT0019022) described in SEQ ID NO: 83 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-4488 gene is disclosed in Jim DD et al., 2010, Blood. 116, e118-e127.
  • hsa-miR-4488 is known as “hsa-mir-4488” (miRBase Accession No. MI0016849, SEQ ID NO: 481) having a hairpin-like structure as a precursor.
  • hsa-miR-4474-3p gene or “hsa-miR-4474-3p” refers to the hsa-miR-4474-3p gene described in SEQ ID NO: 84 (miRBase Accession No. MIMAT0019001) and other species homologues or orthologues are included.
  • the hsa-miR-4474-3p gene is described in Jim DD et al., 2010, Blood. 116, e118-e127.
  • hsa-mir-4474 (miRBase Accession No. MI0016826, SEQ ID NO: 482) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6731-3p gene or “hsa-miR-6731-3p” refers to the hsa-miR-6731-3p gene described in SEQ ID NO: 85 (miRBase Accession No. MIMAT0027364) and other species homologues or orthologues are included.
  • the hsa-miR-6731-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6731-3p” is known as “hsa-mir-6731” (miRBase Accession No. MI0022576, SEQ ID NO: 483) having a hairpin-like structure as a precursor.
  • hsa-miR-4640-3p gene or “hsa-miR-4640-3p” refers to the hsa-miR-4640-3p gene described in SEQ ID NO: 86 (miRBase Accession No. MIMAT0019700) and other species homologs or orthologs.
  • the hsa-miR-4640-3p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4640-3p “hsa-mir-4640” (miRBase Accession No. MI0017267, SEQ ID NO: 484) having a hairpin-like structure as a precursor is known.
  • hsa-miR-202-5p gene or “hsa-miR-202-5p” refers to the hsa-miR-202-5p gene described in SEQ ID NO: 87 (miRBase Accession No. MIMAT0002810) and other species homologues or orthologues are included.
  • the hsa-miR-202-5p gene was obtained from Bentwich I et al., 2005, Nat Genet. 37, 766-770.
  • hsa-miR-202-5p “hsa-mir-202” (miRBase Accession No. MI0003130, SEQ ID NO: 485) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6816-5p gene or “hsa-miR-6816-5p” refers to the hsa-miR-6816-5p gene described in SEQ ID NO: 88 (miRBase Accession No. MIMAT0027532) and other species homologues or orthologues are included.
  • the hsa-miR-6816-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6816-5p” is known as “hsa-mir-6816” (miRBase Accession No. MI0022661, SEQ ID NO: 486), which has a hairpin-like structure as a precursor.
  • hsa-miR-638 gene or “hsa-miR-638” refers to the hsa-miR-638 gene (miRBase Accession No. MIMAT0003308) described in SEQ ID NO: 89 or other species. Homologs or orthologs are included. The hsa-miR-638 gene was found in Cummins JM et al., 2006, Proc Natl Acad Sci USA. 103, 3687-3692. In addition, “hsa-miR-638” is known as “hsa-mir-638” (miRBase Accession No. MI0003653, SEQ ID NO: 487) having a hairpin-like structure as a precursor.
  • hsa-miR-6821-5p gene or “hsa-miR-6821-5p” refers to the hsa-miR-6821-5p gene described in SEQ ID NO: 90 (miRBase Accession No. MIMAT0027542) and other species homologues or orthologues are included.
  • the hsa-miR-6821-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6821-5p” is known as “hsa-mir-6821” (miRBase Accession No. MI0022666, SEQ ID NO: 488) having a hairpin-like structure as a precursor.
  • hsa-miR-1247-3p gene or “hsa-miR-1247-3p” refers to the hsa-miR-1247-3p gene described in SEQ ID NO: 91 (miRBase Accession No. MIMAT0022721) and other species homologues or orthologues are included.
  • the hsa-miR-1247-3p gene is described in Morin RD et al., 2008, Genome Res. 18, 610-621.
  • “hsa-miR-1247-3p” is known as “hsa-mir-1247” (miRBase Accession No. MI0006382, SEQ ID NO: 489) having a hairpin-like structure as a precursor.
  • hsa-miR-6765-5p gene or “hsa-miR-6765-5p” refers to the hsa-miR-6765-5p gene described in SEQ ID NO: 92 (miRBase Accession No. MIMAT0027430) and other species homologs or orthologs.
  • the hsa-miR-6765-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6765-5p “hsa-mir-6765” (miRBase Accession No. MI0022610, SEQ ID NO: 490) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6800-5p gene or “hsa-miR-6800-5p” refers to the hsa-miR-6800-5p gene described in SEQ ID NO: 93 (miRBase Accession No. MIMAT0027500) and other species homologs or orthologs.
  • the hsa-miR-6800-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6800-5p” is known as “hsa-mir-6800” (miRBase Accession No. MI0022645, SEQ ID NO: 491) having a hairpin-like structure as a precursor.
  • hsa-miR-3928-3p gene or “hsa-miR-3928-3p” refers to the hsa-miR-3928-3p gene described in SEQ ID NO: 94 (miRBase Accession No. MIMAT0018205) and other species homologs or orthologs.
  • the hsa-miR-3928-3p gene was obtained from Creighton CJ et al., 2010, PLoS One. 5, Vol. 5, e9637.
  • hsa-miR-3928-3p is known as “hsa-mir-3928” (miRBase Accession No. MI0016438, SEQ ID NO: 492) having a hairpin-like structure as a precursor.
  • hsa-miR-3940-5p gene or “hsa-miR-3940-5p” refers to the hsa-miR-3940-5p gene described in SEQ ID NO: 95 (miRBase Accession No. MIMAT0019229) and other species homologues or orthologues are included.
  • the hsa-miR-3940-5p gene was obtained from Liao JY et al., 2010, PLoS One. 5, Vol. 5, e10563.
  • hsa-miR-3940-5p “hsa-mir-3940” (miRBase Accession No. MI0016597, SEQ ID NO: 493) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3960 gene or “hsa-miR-3960” refers to the hsa-miR-3960 gene (miRBase Accession No. MIMAT0019337) described in SEQ ID NO: 96 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-3960 gene is described in Hu R et al., 2011, J Biol Chem. 286, 12328-12339.
  • hsa-mir-3960 (miRBase Accession No. MI0016964, SEQ ID NO: 494) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6775-5p gene or “hsa-miR-6775-5p” refers to the hsa-miR-6775-5p gene described in SEQ ID NO: 97 (miRBase Accession No. MIMAT0027450) and other species homologs or orthologs.
  • the hsa-miR-6775-5p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6775-5p” is known as “hsa-mir-6775” (miRBase Accession No. MI0022620, SEQ ID NO: 495), which has a hairpin-like structure as a precursor.
  • hsa-miR-3178 gene or “hsa-miR-3178” refers to the hsa-miR-3178 gene (miRBase Accession No. MIMAT0015055) described in SEQ ID NO: 98 or other biological species. Homologs or orthologs are included. The hsa-miR-3178 gene was obtained from Stark MS et al., 2010, PLoS One. No. 5, vol. E9685. As for “hsa-miR-3178”, “hsa-mir-3178” (miRBase Accession No. MI0014212, SEQ ID NO: 496), which has a hairpin-like structure as a precursor, is known.
  • hsa-miR-1202 gene or “hsa-miR- 1202” refers to the hsa-miR- 1202 gene (miRBase Accession No. MIMAT0005865) described in SEQ ID NO: 99 or other species. Homologs or orthologs are included.
  • the hsa-miR- 1202 gene is described in Martin S et al., 2008, Leukemia. , Vol. 22, 330-338.
  • hsa-miR-1202 is known as “hsa-mir-1220” (miRBase Accession No. MI0006334, SEQ ID NO: 497), which has a hairpin-like structure as a precursor.
  • hsa-miR-6790-5p gene or “hsa-miR-6790-5p” refers to the hsa-miR-6790-5p gene described in SEQ ID NO: 100 (miRBase Accession No. MIMAT0027480) and other species homologs or orthologs.
  • the hsa-miR-6790-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6790-5p “hsa-mir-6790” (miRBase Accession No. MI0022635, SEQ ID NO: 498) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4731-3p gene or “hsa-miR-4731-3p” refers to the hsa-miR-4731-3p gene described in SEQ ID NO: 101 (miRBase Accession No. MIMAT0019854) and other species homologs or orthologs.
  • the hsa-miR-4731-3p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4731-3p “hsa-mir-4731” (miRBase Accession No. MI0017368, SEQ ID NO: 499) having a hairpin-like structure as a precursor is known.
  • hsa-miR-2681-3p gene or “hsa-miR-2681-3p” refers to the hsa-miR-2681-3p gene described in SEQ ID NO: 102 (miRBase Accession No. MIMAT0013516) and other species homologues or orthologues are included.
  • the hsa-miR-2681-3p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-2681-3p “hsa-mir-2681” (miRBase Accession No. MI0012062, SEQ ID NO: 500) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6758-5p gene or “hsa-miR-6758-5p” refers to the hsa-miR-6758-5p gene described in SEQ ID NO: 103 (miRBase Accession No. MIMAT0027416) and other species homologs or orthologs.
  • the hsa-miR-6758-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6758-5p “hsa-mir-6758” (miRBase Accession No. MI0022603, SEQ ID NO: 501) having a hairpin-like structure as a precursor is known.
  • hsa-miR-8072 gene or “hsa-miR-8072” refers to the hsa-miR-8072 gene (miRBase Accession No. MIMAT0030999) described in SEQ ID NO: 104 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-8072 gene is disclosed in Wang HJ et al., 2013, Shock. 39, 480-487.
  • hsa-miR-8072 “hsa-mir-8072” (miRBase Accession No. MI0025908, SEQ ID NO: 502) having a hairpin-like structure as a precursor is known.
  • hsa-miR-518d-3p gene or “hsa-miR-518d-3p” refers to the hsa-miR-518d-3p gene described in SEQ ID NO: 105 (miRBase Accession No. MIMAT0002864) and other species homologs or orthologs.
  • the hsa-miR-518d-3p gene was obtained from Bentwich I et al., 2005, Nat Genet. 37, 766-770.
  • hsa-miR-518d-3p “hsa-mir-518d” (miRBase Accession No. MI0003171, SEQ ID NO: 503) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3606-3p gene or “hsa-miR-3606-3p” refers to the hsa-miR-3606-3p gene described in SEQ ID NO: 106 (miRBase Accession No. MIMAT0022965) and other species homologs or orthologs.
  • the hsa-miR-3606-3p gene was obtained from Witten D et al., 2010, BMC Biol. , 8, 58.
  • hsa-mir-3606 (miRBase Accession No. MI0015996, SEQ ID NO: 504) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4800-5p gene or “hsa-miR-4800-5p” refers to the hsa-miR-4800-5p gene described in SEQ ID NO: 107 (miRBase Accession No. MIMAT0019978) and other species homologues or orthologues are included.
  • the hsa-miR-4800-5p gene is described in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • “Hsa-miR-4800-5p” is known as “hsa-mir-4800” (miRBase Accession No. MI0017448, SEQ ID NO: 505), which has a hairpin-like structure as a precursor.
  • hsa-miR-1292-3p gene or “hsa-miR-1292-3p” refers to the hsa-miR-1292-3p gene described in SEQ ID NO: 108 (miRBase Accession No. MIMAT0022948) and other species homologs or orthologs.
  • the hsa-miR-1292-3p gene is described in Morin RD et al., 2008, Genome Res. 18, 610-621.
  • hsa-miR-1292-3p “hsa-mir-1292” (miRBase Accession No. MI0006433, SEQ ID NO: 506) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6784-3p gene or “hsa-miR-6784-3p” refers to the hsa-miR-6784-3p gene described in SEQ ID NO: 109 (miRBase Accession No. MIMAT0027469) and other species homologues or orthologues are included.
  • the hsa-miR-6784-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6784-3p “hsa-mir-6784” (miRBase Accession No. MI0022629, SEQ ID NO: 507) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4450 gene or “hsa-miR-4450” refers to the hsa-miR-4450 gene (miRBase Accession No. MIMAT0018971) described in SEQ ID NO: 110 or other species. Homologs or orthologs are included.
  • the hsa-miR-4450 gene is disclosed in Jim DD et al., 2010, Blood. 116, e118-e127.
  • hsa-mir-4450 (miRBase Accession No. MI0016795, SEQ ID NO: 508) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6132 gene or “hsa-miR-6132” refers to the hsa-miR-6132 gene (miRBase Accession No. MIMAT0024616) described in SEQ ID NO: 111 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-6132 gene is disclosed in Dannemann M et al., 2012, Genome Biol Evol. 4, Volume 552-564.
  • hsa-mir-6132 miRBase Accession No. MI0021277, SEQ ID NO: 509 having a hairpin-like structure as a precursor is known.
  • hsa-miR-4716-5p gene or “hsa-miR-4716-5p” refers to the hsa-miR-4716-5p gene described in SEQ ID NO: 112 (miRBase Accession No. MIMAT0019826) and other species homologues or orthologues are included.
  • the hsa-miR-4716-5p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4716-5p “hsa-mir-4716” (miRBase Accession No. MI0017350, SEQ ID NO: 510) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6860 gene or “hsa-miR-6860” refers to the hsa-miR-6860 gene (miRBase Accession No. MIMAT0027622) described in SEQ ID NO: 113 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-6860 gene was found in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6860 “hsa-mir-6860” (miRBase Accession No. MI0022707, SEQ ID NO: 511) having a hairpin-like structure as a precursor is known.
  • hsa-miR-1268b gene or “hsa-miR-1268b” refers to the hsa-miR-1268b gene (miRBase Accession No. MIMAT0018925) described in SEQ ID NO: 114 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-1268b gene is disclosed in Jim DD et al., 2010, Blood. 116, e118-e127.
  • hsa-miR-1268b is known as “hsa-mir-1268b” (miRBase Accession No. MI0016748, SEQ ID NO: 512) having a hairpin-like structure as a precursor.
  • hsa-miR-378d gene or “hsa-miR-378d” refers to the hsa-miR-378d gene (miRBase Accession No. MIMAT0018926) described in SEQ ID NO: 115 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-378d gene was obtained from Berezikov E et al., 2006, Genome Res. 16, Vol. 1629-1298.
  • “Hsa-miR-378d” has a hairpin-like structure as a precursor thereof, “hsa-mir-378d-1, hsa-mir-378d-2” (miRBase Accession No. MI0016749, MI0003840, SEQ ID NO: 513, 514) is known.
  • hsa-miR-4701-5p gene or “hsa-miR-4701-5p” refers to the hsa-miR-4701-5p gene described in SEQ ID NO: 116 (miRBase Accession No. MIMAT0019798) and other species homologs or orthologs.
  • the hsa-miR-4701-5p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4701-5p “hsa-mir-4701” (miRBase Accession No. MI0017334, SEQ ID NO: 515) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4329 gene or “hsa-miR-4329” refers to the hsa-miR-4329 gene (miRBase Accession No. MIMAT0016923) described in SEQ ID NO: 117 or other biological species. Homologs or orthologs are included. The hsa-miR-4329 gene was found in Goff LA et al., 2009, PLoS One. 4, Volume 4, e7192. In addition, “hsa-miR-4329” is known as “hsa-mir-4329” (miRBase Accession No. MI0015901, SEQ ID NO: 516) having a hairpin-like structure as a precursor.
  • hsa-miR-185-3p gene or “hsa-miR-185-3p” refers to the hsa-miR-185-3p gene described in SEQ ID NO: 118 (miRBase Accession No. MIMAT0004611) and other species homologs or orthologs.
  • the hsa-miR-185-3p gene was obtained from Lagos-Quintana M et al., 2003, RNA. 9, 175-179.
  • hsa-miR-185-3p “hsa-mir-185” (miRBase Accession No. MI000000482, SEQ ID NO: 517) having a hairpin-like structure as a precursor is known.
  • hsa-miR-552-3p gene or “hsa-miR-552-3p” refers to the hsa-miR-552-3p gene described in SEQ ID NO: 119 (miRBase Accession No. MIMAT0003215) and other species homologues or orthologues are included.
  • the hsa-miR-552-3p gene was found in Cummins JM et al., 2006, Proc Natl Acad Sci USA. 103, 3687-3692.
  • “hsa-miR-552-3p” is known as “hsa-mir-552” (miRBase Accession No. MI0003557, SEQ ID NO: 518) having a hairpin-like structure as a precursor.
  • hsa-miR-1273g-5p gene or “hsa-miR-1273g-5p” refers to the hsa-miR-1273g-5p gene described in SEQ ID NO: 120 (miRBase Accession No. MIMAT0020602) and other species homologs or orthologs.
  • the hsa-miR-1273g-5p gene is described in Reshmi G et al., 2011, Genomics. 97, 333-340.
  • hsa-miR-1273g-5p “hsa-mir-1273g” (miRBase Accession No. MI0018003, SEQ ID NO: 519) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6769b-3p gene or “hsa-miR-6769b-3p” refers to the hsa-miR-6769b-3p gene described in SEQ ID NO: 121 (miRBase Accession No. MIMAT0027621) and other species homologues or orthologues are included.
  • the hsa-miR-6769b-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6769b-3p “hsa-mir-6769b” (miRBase Accession No. MI0022706, SEQ ID NO: 520) having a hairpin-like structure as a precursor is known.
  • hsa-miR-520a-3p gene or “hsa-miR-520a-3p” refers to the hsa-miR-520a-3p gene described in SEQ ID NO: 122 (miRBase Accession No. MIMAT0002834) and other species homologs or orthologs.
  • the hsa-miR-520a-3p gene was obtained from Bentwich I et al., 2005, Nat Genet. 37, 766-770.
  • “hsa-miR-520a-3p” is known as “hsa-mir-520a” (miRBase Accession No. MI0003149, SEQ ID NO: 521) having a hairpin-like structure as a precursor.
  • hsa-miR-4524b-5p gene or “hsa-miR-4524b-5p” refers to the hsa-miR-4524b-5p gene described in SEQ ID NO: 123 (miRBase Accession No. MIMAT0022255) and other species homologues or orthologues are included.
  • the hsa-miR-4524b-5p gene is described in Tandon M et al., 2012, Oral Dis. 18 and 127-131.
  • “hsa-miR-4524b-5p” is known as “hsa-mir-4524b” (miRBase Accession No. MI0019114, SEQ ID NO: 522) having a hairpin-like structure as a precursor.
  • hsa-miR-4291 gene or “hsa-miR-4291” refers to the hsa-miR-4291 gene (miRBase Accession No. MIMAT0016922) described in SEQ ID NO: 124 or other biological species. Homologs or orthologs are included. The hsa-miR-4291 gene was found in Goff LA et al., 2009, PLoS One. 4, Volume 4, e7192. As for “hsa-miR-4291”, “hsa-mir-4291” (miRBase Accession No. MI0015900, SEQ ID NO: 523) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6734-3p gene or “hsa-miR-6734-3p” refers to the hsa-miR-6734-3p gene described in SEQ ID NO: 125 (miRBase Accession No. MIMAT0027370) and other species homologues or orthologues are included.
  • the hsa-miR-6734-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6734-3p” is known as “hsa-mir-6734” (miRBase Accession No. MI0022579, SEQ ID NO: 524) having a hairpin-like structure as a precursor.
  • hsa-miR-143-5p gene or “hsa-miR-143-5p” refers to the hsa-miR-143-5p gene described in SEQ ID NO: 126 (miRBase Accession No. MIMAT0004599) and other species homologs or orthologs.
  • the hsa-miR-143-5p gene was obtained from Lagos-Quintana M et al., 2002, Curr Biol. 12, Vol. 735-739.
  • “Hsa-miR-143-5p” is known as “hsa-mir-143” (miRBase Accession No. MI000059, SEQ ID NO: 525) having a hairpin-like structure as a precursor.
  • hsa-miR-939-3p gene or “hsa-miR-939-3p” refers to the hsa-miR-939-3p gene described in SEQ ID NO: 127 (miRBase Accession No. MIMAT0022939) and other species homologues or orthologues are included.
  • the hsa-miR-939-3p gene is disclosed in Lui WO et al., 2007, Cancer Res. 67, 6031-6043.
  • “hsa-miR-939-3p” is known as “hsa-mir-939” (miRBase Accession No. MI0005761, SEQ ID NO: 526) having a hairpin-like structure as a precursor.
  • hsa-miR-6889-3p gene or “hsa-miR-6889-3p” refers to the hsa-miR-6889-3p gene (miRBase Accession No. MIMAT0027679) and other species homologues or orthologues are included.
  • the hsa-miR-6889-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6889-3p” is known as “hsa-mir-6889” (miRBase Accession No. MI0022736, SEQ ID NO: 527) having a hairpin-like structure as a precursor.
  • hsa-miR-6842-3p gene or “hsa-miR-6842-3p” refers to the hsa-miR-6842-3p gene described in SEQ ID NO: 129 (miRBase Accession No. MIMAT0027587) and other species homologs or orthologs.
  • the hsa-miR-6842-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-mir-6842 miRBase Accession No. MI0022688, SEQ ID NO: 528) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4511 gene or “hsa-miR-4511” refers to the hsa-miR-4511 gene (miRBase Accession No. MIMAT0019048) described in SEQ ID NO: 130 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-4511 gene is disclosed in Jim DD et al., 2010, Blood. 116, e118-e127.
  • hsa-mir-4511 (miRBase Accession No. MI0016877, SEQ ID NO: 529) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4318 gene or “hsa-miR-4318” refers to the hsa-miR-4318 gene (miRBase Accession No. MIMAT0016869) described in SEQ ID NO: 131 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-4318 gene was obtained from Goff LA et al., 2009, PLoS One. 4, Volume 4, e7192.
  • hsa-miR-4318 “hsa-mir-4318” (miRBase Accession No. MI0015847, SEQ ID NO: 530) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4653-5p gene or “hsa-miR-4653-5p” refers to the hsa-miR-4653-5p gene (miRBase Accession No. MIMAT0019718) and other species homologues or orthologues are included.
  • the hsa-miR-4653-5p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4653-5p “hsa-mir-4653” (miRBase Accession No. MI0017281, SEQ ID NO: 531) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6867-3p gene or “hsa-miR-6867-3p” refers to the hsa-miR-6867-3p gene described in SEQ ID NO: 133 (miRBase Accession No. MIMAT0027635) and other species homologs or orthologs.
  • the hsa-miR-6867-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6867-3p” is known as “hsa-mir-6867” (miRBase Accession No. MI0022714, SEQ ID NO: 532) having a hairpin-like structure as a precursor.
  • hsa-miR-133b gene or “hsa-miR-133b” refers to the hsa-miR-133b gene (miRBase Accession No. MIMAT000070) described in SEQ ID NO: 134 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-133b gene is described in Lim LP et al., 2003, Science. 299, 1540.
  • “hsa-miR-133b” is known as “hsa-mir-133b” (miRBase Accession No. MI000022, SEQ ID NO: 533) having a hairpin-like structure as a precursor.
  • hsa-miR-3196 gene or “hsa-miR-3196” refers to the hsa-miR-3196 gene (miRBase Accession No. MIMAT0015080) described in SEQ ID NO: 135 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-3196 gene was obtained from Stark MS et al., 2010, PLoS One. No. 5, vol. E9685.
  • hsa-miR-3196 “hsa-mir-3196” (miRBase Accession No. MI0014241, SEQ ID NO: 534) having a hairpin-like structure as a precursor is known.
  • hsa-miR-193b-3p gene or “hsa-miR-193b-3p” refers to the hsa-miR-193b-3p gene described in SEQ ID NO: 136 (miRBase Accession No. MIMAT0002819) and other species homologs or orthologs.
  • the hsa-miR-193b-3p gene was obtained from Bentwich I et al., 2005, Nat Genet. 37, 766-770.
  • hsa-miR-193b-3p “hsa-mir-193b” (miRBase Accession No. MI0003137, SEQ ID NO: 535) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3162-3p gene or “hsa-miR-3162-3p” refers to the hsa-miR-3162-3p gene described in SEQ ID NO: 137 (miRBase Accession No. MIMAT0019213) and other species homologs or orthologs.
  • the hsa-miR-3162-3p gene was obtained from Stark MS et al., 2010, PLoS One. No. 5, vol. E9685.
  • “Hsa-miR-3162-3p” is known as “hsa-mir-3162” (miRBase Accession No. MI0014192, SEQ ID NO: 536) having a hairpin-like structure as a precursor.
  • hsa-miR-6819-3p gene or “hsa-miR-6819-3p” refers to the hsa-miR-6819-3p gene described in SEQ ID NO: 138 (miRBase Accession No. MIMAT0027539) and other species homologs or orthologs.
  • the hsa-miR-6819-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6819-3p” is known as “hsa-mir-6819” (miRBase Accession No. MI0022664, SEQ ID NO: 537) having a hairpin-like structure as a precursor.
  • hsa-miR-1908-3p gene or “hsa-miR-1908-3p” refers to the hsa-miR-1908-3p gene described in SEQ ID NO: 139 (miRBase Accession No. MIMAT0026916) and other species homologs or orthologs.
  • the hsa-miR-1908-3p gene is described in Bar M et al., 2008, Stem Cells. 26, 2496-2505.
  • hsa-miR-1908-3p “hsa-mir-1908” (miRBase Accession No. MI0008329, SEQ ID NO: 538) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6786-5p gene or “hsa-miR-6786-5p” refers to the hsa-miR-6786-5p gene described in SEQ ID NO: 140 (miRBase Accession No. MIMAT0027472) and other species homologues or orthologues are included.
  • the hsa-miR-6786-5p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6786-5p “hsa-mir-6786” (miRBase Accession No. MI0022631, SEQ ID NO: 539) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3648 gene or “hsa-miR-3648” refers to the hsa-miR-3648 gene (miRBase Accession No. MIMAT0018068) described in SEQ ID NO: 141 or other biological species. Homologs or orthologs are included. The hsa-miR-3648 gene was found in Meiri E et al., 2010, Nucleic Acids Res. 38, 6234-6246.
  • “Hsa-miR-3648” has a hairpin-like structure as its precursor, “hsa-mir-3648-1, hsa-mir-3648-2” (miRBase Accession No. MI0016048, MI0031512, SEQ ID NO: 540, 541) is known.
  • hsa-miR-4513 gene or “hsa-miR-4513” refers to the hsa-miR-4513 gene (miRBase Accession No. MIMAT0019050) described in SEQ ID NO: 142 or other species. Homologs or orthologs are included.
  • the hsa-miR-4513 gene is disclosed in Jim DD et al., 2010, Blood. 116, e118-e127.
  • hsa-mir-4513 (miRBase Accession No. MI0016879, SEQ ID NO: 542) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3652 gene or “hsa-miR-3652” refers to the hsa-miR-3652 gene (miRBase Accession No. MIMAT0018072) described in SEQ ID NO: 143 or other biological species. Homologs or orthologs are included. The hsa-miR-3652 gene was found in Meiri E et al., 2010, Nucleic Acids Res. 38, 6234-6246. As for “hsa-miR-3652”, “hsa-mir-3652” (miRBase Accession No. MI0016052, SEQ ID NO: 543) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4640-5p gene or “hsa-miR-4640-5p” refers to the hsa-miR-4640-5p gene described in SEQ ID NO: 144 (miRBase Accession No. MIMAT0019699) and other species homologs or orthologs.
  • the hsa-miR-4640-5p gene is described in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4640-5p “hsa-mir-4640” (miRBase Accession No. MI0017267, SEQ ID NO: 484) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6871-5p gene or “hsa-miR-6871-5p” refers to the hsa-miR-6871-5p gene described in SEQ ID NO: 145 (miRBase Accession No. MIMAT0027642) and other species homologues or orthologues are included.
  • the hsa-miR-6871-5p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “Hsa-miR-6871-5p” is known as “hsa-mir-6871” (miRBase Accession No. MI0022718, SEQ ID NO: 544) having a hairpin-like structure as a precursor.
  • hsa-miR-7845-5p gene or “hsa-miR-7845-5p” refers to the hsa-miR-7845-5p gene described in SEQ ID NO: 146 (miRBase Accession No. MIMAT0030420) and other species homologs or orthologs.
  • the hsa-miR-7845-5p gene was found in Ple H et al., 2012, PLoS One. 7, Vol. 7, e50746.
  • hsa-miR-7845-5p “hsa-mir-7845” (miRBase Accession No. MI0025515, SEQ ID NO: 545) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3138 gene or “hsa-miR-3138” refers to the hsa-miR-3138 gene (miRBase Accession No. MIMAT0015006) described in SEQ ID NO: 147 or other biological species. Homologs or orthologs are included. The hsa-miR-3138 gene was found in Creighton CJ et al., 2010, PLoS One. 5, Vol. 5, e9637. In addition, “hsa-miR-3138” is known as “hsa-mir-3138” (miRBase Accession No. MI0014161, SEQ ID NO: 546) having a hairpin-like structure as a precursor.
  • hsa-miR-6884-5p gene or “hsa-miR-6884-5p” refers to the hsa-miR-6884-5p gene described in SEQ ID NO: 148 (miRBase Accession No. MIMAT0027668) and other species homologues or orthologues are included.
  • the hsa-miR-6884-5p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6844-5p” is known as “hsa-mir-6844” (miRBase Accession No. MI0022731, SEQ ID NO: 547) having a hairpin-like structure as a precursor.
  • hsa-miR-4653-3p gene or “hsa-miR-4653-3p” refers to the hsa-miR-4653-3p gene described in SEQ ID NO: 149 (miRBase Accession No. MIMAT0019719) and other species homologues or orthologues are included.
  • the hsa-miR-4653-3p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • “hsa-miR-4653-3p” is known as “hsa-mir-4653” (miRBase Accession No. MI0017281, SEQ ID NO: 531) having a hairpin-like structure as a precursor.
  • hsa-miR-636 gene or “hsa-miR-636” refers to the hsa-miR-636 gene (miRBase Accession No. MIMAT0003306) described in SEQ ID NO: 150 or other biological species. Homologs or orthologs are included. The hsa-miR-636 gene was found in Cummins JM et al., 2006, Proc Natl Acad Sci USA. 103, 3687-3692. In addition, “hsa-miR-636” is known as “hsa-mir-636” (miRBase Accession No. MI0003651, SEQ ID NO: 548) having a hairpin-like structure as a precursor.
  • hsa-miR-4652-3p gene or “hsa-miR-4652-3p” refers to the hsa-miR-4652-3p gene described in SEQ ID NO: 151 (miRBase Accession No. MIMAT0019717) and other species homologues or orthologues are included.
  • the hsa-miR-4652-3p gene is described in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • “hsa-miR-4652-3p” is known as “hsa-mir-4652” (miRBase Accession No. MI0017280, SEQ ID NO: 549) having a hairpin-like structure as a precursor.
  • hsa-miR-6823-5p gene or “hsa-miR-6823-5p” refers to the hsa-miR-6823-5p gene described in SEQ ID NO: 152 (miRBase Accession No. MIMAT0027546) and other species homologues or orthologues are included.
  • the hsa-miR-6823-5p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6823-5p “hsa-mir-6823” (miRBase Accession No. MI0022668, SEQ ID NO: 550) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4502 gene or “hsa-miR-4502” refers to the hsa-miR-4502 gene (miRBase Accession No. MIMAT0019038) described in SEQ ID NO: 153 or other species. Homologs or orthologs are included.
  • the hsa-miR-4502 gene is disclosed in Jim DD et al., 2010, Blood. 116, e118-e127.
  • “Hsa-miR-4502” is known as “hsa-mir-4502” (miRBase Accession No. MI0016865, SEQ ID NO: 551), which has a hairpin-like structure as a precursor.
  • hsa-miR-7113-5p gene or “hsa-miR-7113-5p” refers to the hsa-miR-7113-5p gene described in SEQ ID NO: 154 (miRBase Accession No. MIMAT0028123) and other species homologues or orthologues are included.
  • the hsa-miR-7113-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-7113-5p is known as “hsa-mir-7113” (miRBase Accession No. MI0022964, SEQ ID NO: 552) having a hairpin-like structure as a precursor.
  • hsa-miR-8087 gene or “hsa-miR-8087” refers to the hsa-miR-8087 gene (miRBase Accession No. MIMAT0031014) described in SEQ ID NO: 155 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-8087 gene is described in Wang HJ et al., 2013, Shock. 39, 480-487.
  • hsa-miR-8087 “hsa-mir-8087” (miRBase Accession No. MI0025923, SEQ ID NO: 553) having a hairpin-like structure as a precursor is known.
  • hsa-miR-7154-3p gene or “hsa-miR-7154-3p” refers to the hsa-miR-7154-3p gene described in SEQ ID NO: 156 (miRBase Accession No. MIMAT0028219) and other species homologues or orthologues are included.
  • the hsa-miR-7154-3p gene is described in Meunier J et al., 2013, Genome Res. 23, 34-45.
  • “hsa-miR-7154-3p” is known as “hsa-mir-7154” (miRBase Accession No. MI0023614, SEQ ID NO: 554) having a hairpin-like structure as a precursor.
  • hsa-miR-5189-5p gene or “hsa-miR-5189-5p” refers to the hsa-miR-5189-5p gene described in SEQ ID NO: 157 (miRBase Accession No. MIMAT0021120) and other species homologs or orthologs.
  • the hsa-miR-5189-5p gene was obtained from Schotte D et al., 2011, Leukemia. 25, 1389-1399.
  • hsa-miR-5189-5p “hsa-mir-5189” (miRBase Accession No. MI0018168, SEQ ID NO: 555) having a hairpin-like structure as a precursor is known.
  • hsa-miR-1253 gene or “hsa-miR-1253” refers to the hsa-miR-1253 gene (miRBase Accession No. MIMAT0005904) described in SEQ ID NO: 158 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-1253 gene is described in Morin RD et al., 2008, Genome Res. 18, 610-621.
  • hsa-mir-1253 miRBase Accession No. MI0006387, SEQ ID NO: 556) having a hairpin-like structure as a precursor is known.
  • hsa-miR-518c-5p gene or “hsa-miR-518c-5p” refers to the hsa-miR-518c-5p gene described in SEQ ID NO: 159 (miRBase Accession No. MIMAT0002847) and other species homologs or orthologs.
  • the hsa-miR-518c-5p gene was obtained from Bentwich I et al., 2005, Nat Genet. 37, 766-770.
  • “hsa-miR-518c-5p” is known as “hsa-mir-518c” (miRBase Accession No. MI0003159, SEQ ID NO: 557) having a hairpin-like structure as a precursor.
  • hsa-miR-7151-5p gene or “hsa-miR-7151-5p” refers to the hsa-miR-7151-5p gene described in SEQ ID NO: 160 (miRBase Accession No. MIMAT0028212) and other species homologs or orthologs.
  • the hsa-miR-7151-5p gene is described in Meunier J et al., 2013, Genome Res. 23, 34-45.
  • hsa-mir-7151 miRBase Accession No. MI0023611, SEQ ID NO: 558 having a hairpin-like structure as a precursor is known.
  • hsa-miR-3614-3p gene or “hsa-miR-3614-3p” refers to the hsa-miR-3614-3p gene described in SEQ ID NO: 161 (miRBase Accession No. MIMAT0017993) and other species homologues or orthologues are included.
  • the hsa-miR-3614-3p gene was obtained from Witten D et al., 2010, BMC Biol. , 8, 58.
  • “hsa-miR-3614-3p” “hsa-mir-3614” (miRBase Accession No. MI0016004, SEQ ID NO: 559) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4727-5p gene or “hsa-miR-4727-5p” refers to the hsa-miR-4727-5p gene described in SEQ ID NO: 162 (miRBase Accession No. MIMAT0019847) and other species homologues or orthologues are included.
  • the hsa-miR-4727-5p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4727-5p “hsa-mir-4727” (miRBase Accession No. MI0017364, SEQ ID NO: 560) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3682-5p gene or “hsa-miR-3682-5p” refers to the hsa-miR-3682-5p gene described in SEQ ID NO: 163 (miRBase Accession No. MIMAT0019222) and other species homologues or orthologues are included.
  • the hsa-miR-3682-5p gene was obtained from Vaz C et al., 2010, BMC Genomics. 11 and 288.
  • hsa-miR-3682-5p “hsa-mir-3682” (miRBase Accession No. MI0016083, SEQ ID NO: 561) having a hairpin-like structure as a precursor is known.
  • hsa-miR-5090 gene or “hsa-miR-5090” refers to the hsa-miR-5090 gene (miRBase Accession No. MIMAT0021082) described in SEQ ID NO: 164 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-5090 gene is disclosed in Ding N et al., 2011, J Radiat Res. 52, 425-432.
  • hsa-miR-5090 “hsa-mir-5090” (miRBase Accession No. MI0017979, SEQ ID NO: 562) having a hairpin-like structure as a precursor is known.
  • hsa-miR-337-3p gene or “hsa-miR-337-3p” refers to the hsa-miR-337-3p gene (miRBase Accession No. 165 described in SEQ ID NO: 165). MIMAT0000754) and other species homologs or orthologs.
  • the hsa-miR-337-3p gene was found in Kim J et al., 2004, Proc Natl Acad Sci USA. 101, 360-365.
  • hsa-mir-337 (miRBase Accession No. MI00000806, SEQ ID NO: 563) having a hairpin-like structure as a precursor is known.
  • hsa-miR-488-5p gene or “hsa-miR-488-5p” refers to the hsa-miR-488-5p gene described in SEQ ID NO: 166 (miRBase Accession No. MIMAT0002804) and other species homologues or orthologues are included.
  • the hsa-miR-488-5p gene was obtained from Bentwich I et al., 2005, Nat Genet. 37, 766-770.
  • hsa-miR-488-5p “hsa-mir-488” (miRBase Accession No. MI0003123, SEQ ID NO: 564), which has a hairpin-like structure as a precursor, is known.
  • hsa-miR-100-5p gene or “hsa-miR-100-5p” refers to the hsa-miR-100-5p gene described in SEQ ID NO: 167 (miRBase Accession No. MIMAT00000098) and other species homologs or orthologs.
  • the hsa-miR-100-5p gene is described in Mouretos Z et al., 2002, Genes Dev. 16, 720-728.
  • “hsa-miR-100-5p” is known as “hsa-mir-100” (miRBase Accession No. MI0000102, SEQ ID NO: 565) having a hairpin-like structure as a precursor.
  • hsa-miR-4520-3p gene or “hsa-miR-4520-3p” refers to the hsa-miR-4520-3p gene described in SEQ ID NO: 168 (miRBase Accession No. MIMAT0019057) and other species homologs or orthologs.
  • the hsa-miR-4520-3p gene is described in Jim DD et al., 2010, Blood. 116, e118-e127.
  • “hsa-miR-4520-3p” is known as “hsa-mir-4520-1” (miRBase Accession No. MI0016886, SEQ ID NO: 566) having a hairpin-like structure as a precursor.
  • hsa-miR-373-3p gene or “hsa-miR-373-3p” refers to the hsa-miR-373-3p gene described in SEQ ID NO: 169 (miRBase Accession No. MIMAT000026) and other species homologues or orthologues are included.
  • the hsa-miR-373-3p gene was obtained from Suh MR et al., 2004, Dev Biol. 270, 488-498.
  • “hsa-miR-373-3p” is known as “hsa-mir-373” (miRBase Accession No. MI0000811, SEQ ID NO: 567) having a hairpin-like structure as a precursor.
  • hsa-miR-6499-5p gene or “hsa-miR-6499-5p” refers to the hsa-miR-6499-5p gene described in SEQ ID NO: 170 (miRBase Accession No. MIMAT0025450) and other species homologs or orthologs.
  • the hsa-miR-6499-5p gene was obtained from Joyce CE et al., 2011, Hum Mol Genet. 20, Vol. 4025-4040.
  • “hsa-miR-6499-5p” is known as “hsa-mir-6499” (miRBase Accession No. MI0022209, SEQ ID NO: 568) having a hairpin-like structure as a precursor.
  • hsa-miR-3909 gene or “hsa-miR-3909” refers to the hsa-miR-3909 gene (miRBase Accession No. MIMAT0018183) described in SEQ ID NO: 171 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-3909 gene was obtained from Creighton CJ et al., 2010, PLoS One. 5, Vol. 5, e9637.
  • hsa-miR-3909 “hsa-mir-3909” (miRBase Accession No. MI0016413, SEQ ID NO: 569) having a hairpin-like structure as a precursor is known.
  • hsa-miR-32-5p gene or “hsa-miR-32-5p” refers to the hsa-miR-32-5p gene described in SEQ ID NO: 172 (miRBase Accession No. MIMAT000090) and other species homologs or orthologs.
  • the hsa-miR-32-5p gene is disclosed in Lagos-Quintana M et al., 2001, Science. 294, 853-858.
  • “Hsa-miR-32-5p” is known as “hsa-mir-32” (miRBase Accession No. MI00000090, SEQ ID NO: 570) having a hairpin-like structure as a precursor.
  • hsa-miR-302a-3p gene or “hsa-miR-302a-3p” refers to the hsa-miR-302a-3p gene (miRBase Accession No. 173 described in SEQ ID NO: 173). MIMAT0000684) and other species homologs or orthologs.
  • the hsa-miR-302a-3p gene was obtained from Houbevy HB et al., 2003, Dev Cell. No. 5, 351-358.
  • hsa-mir-302a (miRBase Accession No. MI000038, SEQ ID NO: 571) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4686 gene or “hsa-miR-4686” refers to the hsa-miR-4686 gene (miRBase Accession No. MIMAT0019773) described in SEQ ID NO: 174 or other biological species. Homologs or orthologs are included. The hsa-miR-4686 gene was found in Persson H et al., 2011, Cancer Res. 71, 78-86. As for “hsa-miR-4686”, “hsa-mir-4686” (miRBase Accession No. MI0017318, SEQ ID NO: 572) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4659a-3p gene or “hsa-miR-4659a-3p” refer to the hsa-miR-4659a-3p gene described in SEQ ID NO: 175 (miRBase Accession No. MIMAT0019727) and other species homologues or orthologues are included.
  • the hsa-miR-4659a-3p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • “hsa-miR-4659a-3p” “hsa-mir-4659a” (miRBase Accession No. MI0017287, SEQ ID NO: 573) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4287 gene or “hsa-miR-4287” refers to the hsa-miR-4287 gene (miRBase Accession No. MIMAT0016917) described in SEQ ID NO: 176 or other biological species. Homologs or orthologs are included. The hsa-miR-4287 gene was found in Goff LA et al., 2009, PLoS One. 4, Volume 4, e7192. As for “hsa-miR-4287”, “hsa-mir-4287” (miRBase Accession No. MI0015895, SEQ ID NO: 574) having a hairpin-like structure as a precursor is known.
  • hsa-miR-1301-5p gene or “hsa-miR-1301-5p” refers to the hsa-miR-1301-5p gene described in SEQ ID NO: 177 (miRBase Accession No. MIMAT0026639) and other species homologs or orthologs.
  • the hsa-miR-1301-5p gene is described in Berezikov E et al., 2006, Genome Res. 16, Vol. 1629-1298.
  • hsa-mir-1301 miRBase Accession No. MI0003815, SEQ ID NO: 575 having a hairpin-like structure as a precursor is known.
  • hsa-miR-593-3p gene or “hsa-miR-593-3p” refers to the hsa-miR-593-3p gene described in SEQ ID NO: 178 (miRBase Accession No. MIMAT0004802) and other species homologues or orthologues are included.
  • the hsa-miR-593-3p gene was found in Cummins JM et al., 2006, Proc Natl Acad Sci USA. 103, 3687-3692.
  • hsa-miR-593-3p “hsa-mir-593” (miRBase Accession No. MI0003605, SEQ ID NO: 576) having a hairpin-like structure as a precursor is known.
  • hsa-miR-517a-3p gene or “hsa-miR-517a-3p” refers to the hsa-miR-517a-3p gene described in SEQ ID NO: 179 (miRBase Accession No. MIMAT0002852) and other species homologues or orthologues are included.
  • the hsa-miR-517a-3p gene was obtained from Bentwich I et al., 2005, Nat Genet. 37, 766-770.
  • hsa-miR-517a-3p “hsa-mir-517a” (miRBase Accession No. MI0003161, SEQ ID NO: 577) having a hairpin-like structure as a precursor is known.
  • hsa-miR-517b-3p gene or “hsa-miR-517b-3p” refers to the hsa-miR-517b-3p gene described in SEQ ID NO: 180 (miRBase Accession No. MIMAT0002857) and other species homologs or orthologs.
  • the hsa-miR-517b-3p gene was obtained from Bentwich I et al., 2005, Nat Genet. 37, 766-770.
  • hsa-miR-517b-3p “hsa-mir-517b” (miRBase Accession No. MI0003165, SEQ ID NO: 578) having a hairpin-like structure as a precursor is known.
  • hsa-miR-142-3p gene or “hsa-miR-142-3p” refers to the hsa-miR-142-3p gene described in SEQ ID NO: 181 (miRBase Accession No. MIMAT000034) and other species homologues or orthologues are included.
  • the hsa-miR-142-3p gene was obtained from Lagos-Quintana M et al., 2002, Curr Biol. 12, Vol. 735-739.
  • “hsa-miR-142-3p” is known as “hsa-mir-142” (miRBase Accession No. MI0000458, SEQ ID NO: 579) having a hairpin-like structure as a precursor.
  • hsa-miR-1185-2-3p gene or “hsa-miR-1185-2-3p” as used herein refers to the hsa-miR-1185-2-3p described in SEQ ID NO: 182. Genes (miRBBase Accession No. MIMAT0022713) and other species homologues or orthologues are included.
  • the hsa-miR-1185-2-3p gene was obtained from Berezikov E et al., 2006, Genome Res. 16, Vol. 1629-1298.
  • hsa-mir-1185-2 miRBase Accession No. MI0003821, SEQ ID NO: 580 having a hairpin-like structure as a precursor is known.
  • hsa-miR-602 gene or “hsa-miR-602” refers to the hsa-miR-602 gene (miRBase Accession No. MIMAT0003270) described in SEQ ID NO: 183 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-602 gene was obtained from Cummins JM et al., 2006, Proc Natl Acad Sci U SA. 103, 3687-3692.
  • hsa-miR-602 “hsa-mir-602” (miRBase Accession No. MI0003615, SEQ ID NO: 581) having a hairpin-like structure as a precursor is known.
  • hsa-miR-527 gene or “hsa-miR-527” refers to the hsa-miR-527 gene (miRBase Accession No. MIMAT0002862) described in SEQ ID NO: 184 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-527 gene was obtained from Bentwich I et al., 2005, Nat Genet. 37, 766-770.
  • hsa-miR-527 “hsa-mir-527” (miRBase Accession No. MI0003179, SEQ ID NO: 582) having a hairpin-like structure as a precursor is known.
  • hsa-miR-518a-5p gene or “hsa-miR-518a-5p” refers to the hsa-miR-518a-5p gene described in SEQ ID NO: 185 (miRBase Accession No. MIMAT0005457) and other species homologues or orthologues are included.
  • the hsa-miR-518a-5p gene was obtained from Bentwich I et al., 2005, Nat Genet. 37, 766-770.
  • “Hsa-miR-518a-5p” has a hairpin-like structure as a precursor thereof, “hsa-mir-518a-1, hsa-mir-518a-2” (miRBase Accession No. MI0003170, MI0003173, SEQ ID NO: 583, 584) is known.
  • hsa-miR-4682 gene or “hsa-miR-4682” refers to the hsa-miR-4682 gene (miRBase Accession No. MIMAT0019767) described in SEQ ID NO: 186 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-4682 gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • “hsa-miR-4682” is known as “hsa-mir-4682” (miRBase Accession No. MI0017314, SEQ ID NO: 585), which has a hairpin-like structure as a precursor.
  • hsa-miR-28-5p gene or “hsa-miR-28-5p” refers to the hsa-miR-28-5p gene (miRBase Accession No. 187 described in SEQ ID NO: 187). MIMAT0000085) and other species homologs or orthologs.
  • the hsa-miR-28-5p gene is described in Lagos-Quintana M et al., 2001, Science. 294, 853-858.
  • “hsa-miR-28-5p” is known as “hsa-mir-28” (miRBase Accession No. MI0000086, SEQ ID NO: 586) having a hairpin-like structure as a precursor.
  • hsa-miR-4252 gene or “hsa-miR-4252” refers to the hsa-miR-4252 gene (miRBase Accession No. MIMAT0016886) described in SEQ ID NO: 188 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-4252 gene was obtained from Goff LA et al., 2009, PLoS One. 4, Volume 4, e7192.
  • hsa-miR-4252 “hsa-mir-4252” (miRBase Accession No. MI0015864, SEQ ID NO: 587) having a hairpin-like structure as a precursor is known.
  • hsa-miR-452-5p gene or “hsa-miR-452-5p” refers to the hsa-miR-452-5p gene described in SEQ ID NO: 189 (miRBase Accession No. MIMAT001635) and other species homologs or orthologs.
  • the hsa-miR-452-5p gene was obtained from Altvia Y et al., 2005, Nucleic Acids Res. 33, 2697-2706.
  • “hsa-miR-452-5p” is known as “hsa-mir-452” (miRBase Accession No. MI0001733, SEQ ID NO: 588) having a hairpin-like structure as a precursor.
  • hsa-miR-525-5p gene or “hsa-miR-525-5p” refers to the hsa-miR-525-5p gene described in SEQ ID NO: 190 (miRBase Accession No. MIMAT0002838) and other species homologs or orthologs.
  • the hsa-miR-525-5p gene was obtained from Bentwich I et al., 2005, Nat Genet. 37, 766-770.
  • “hsa-miR-525-5p” is known as “hsa-mir-525” (miRBase Accession No. MI0003152, SEQ ID NO: 589) having a hairpin-like structure as a precursor.
  • hsa-miR-3622a-3p gene or “hsa-miR-3622a-3p” refers to the hsa-miR-3622a-3p gene (miRBase Accession No. MIMAT0018004) and other species homologs or orthologs.
  • the hsa-miR-3622a-3p gene was obtained from Witten D et al., 2010, BMC Biol. , 8, 58.
  • “hsa-miR-3622a-3p” is known as “hsa-mir-3622a” (miRBase Accession No. MI0016013, SEQ ID NO: 590) having a hairpin-like structure as a precursor.
  • hsa-miR-6813-3p gene or “hsa-miR-6813-3p” refers to the hsa-miR-6813-3p gene described in SEQ ID NO: 192 (miRBase Accession No. MIMAT0027527) and other species homologues or orthologues are included.
  • the hsa-miR-6813-3p gene was obtained from Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “Hsa-miR-6813-3p” is known as “hsa-mir-6683” (miRBase Accession No. MI0022658, SEQ ID NO: 591) having a hairpin-like structure as a precursor.
  • hsa-miR-4769-3p gene or “hsa-miR-4769-3p” refers to the hsa-miR-4769-3p gene described in SEQ ID NO: 193 (miRBase Accession No. MIMAT0019923) and other species homologues or orthologues are included.
  • the hsa-miR-4769-3p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4769-3p “hsa-mir-4769” (miRBase Accession No. MI0017410, SEQ ID NO: 592) having a hairpin-like structure as a precursor is known.
  • hsa-miR-5698 gene or “hsa-miR-5698” refers to the hsa-miR-5698 gene (miRBase Accession No. MIMAT0022491) described in SEQ ID NO: 194 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-5698 gene was obtained from Watahiki A et al., 2011, PLoS One. 6, Volume 24, e24950.
  • hsa-miR-5698 “hsa-mir-5698” (miRBase Accession No. MI0019305, SEQ ID NO: 593) having a hairpin-like structure as a precursor is known.
  • hsa-miR-1915-3p gene or “hsa-miR-1915-3p” refers to the hsa-miR-1915-3p gene described in SEQ ID NO: 195 (miRBase Accession No. MIMAT0007892) and other species homologues or orthologues are included.
  • the hsa-miR-1915-3p gene is described in Bar M et al., 2008, Stem Cells. 26, 2496-2505.
  • “hsa-miR-1915-3p” is known as “hsa-mir-1915” (miRBase Accession No. MI0008336, SEQ ID NO: 594) having a hairpin-like structure as a precursor.
  • hsa-miR-1343-5p gene or “hsa-miR-1343-5p” refers to the hsa-miR-1343-5p gene described in SEQ ID NO: 196 (miRBase Accession No. MIMAT0027038) and other species homologs or orthologs.
  • the hsa-miR-1343-5p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • “hsa-miR-1343-5p” is known as “hsa-mir-1343” (miRBase Accession No. MI0017320, SEQ ID NO: 595) having a hairpin-like structure as a precursor.
  • hsa-miR-6861-5p gene or “hsa-miR-6861-5p” refers to the hsa-miR-6861-5p gene described in SEQ ID NO: 197 (miRBase Accession No. MIMAT0027623) and other species homologues or orthologues are included.
  • the hsa-miR-6861-5p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6861-5p “hsa-mir-6861” (miRBase Accession No. MI0022708, SEQ ID NO: 596) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6781-5p gene or “hsa-miR-6781-5p” refers to the hsa-miR-6781-5p gene described in SEQ ID NO: 198 (miRBase Accession No. MIMAT0027462) and other species homologues or orthologues are included.
  • the hsa-miR-6781-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6781-5p” is known as “hsa-mir-6781” (miRBase Accession No. MI0022626, SEQ ID NO: 597) having a hairpin-like structure as a precursor.
  • hsa-miR-4508 gene or “hsa-miR-4508” refers to the hsa-miR-4508 gene (miRBase Accession No. MIMAT0019045) described in SEQ ID NO: 199 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-4508 gene is described in Jim DD et al., 2010, Blood. 116, e118-e127.
  • hsa-mir-4508 (miRBase Accession No. MI0016872, SEQ ID NO: 598) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6743-5p gene or “hsa-miR-6743-5p” refers to the hsa-miR-6743-5p gene described in SEQ ID NO: 200 (miRBase Accession No. MIMAT0027387) and other species homologues or orthologues are included.
  • the hsa-miR-6743-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6743-5p” is known as “hsa-mir-6743” (miRBase Accession No. MI0022588, SEQ ID NO: 599) having a hairpin-like structure as a precursor.
  • hsa-miR-6726-5p gene or “hsa-miR-6726-5p” refers to the hsa-miR-6726-5p gene described in SEQ ID NO: 201 (miRBase Accession No. MIMAT0027353) and other species homologues or orthologues are included.
  • the hsa-miR-6726-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6726-5p “hsa-mir-6726” (miRBase Accession No. MI0022571, SEQ ID NO: 600) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4525 gene or “hsa-miR-4525” refers to the hsa-miR-4525 gene (miRBase Accession No. MIMAT0019064) described in SEQ ID NO: 202 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-4525 gene is disclosed in Jim DD et al., 2010, Blood. 116, e118-e127.
  • hsa-mir-4525 (miRBase Accession No. MI0016892, SEQ ID NO: 601) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4651 gene or “hsa-miR-4651” refers to the hsa-miR-4651 gene (miRBase Accession No. MIMAT0019715) described in SEQ ID NO: 203 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-4651 gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • “Hsa-miR-4651” is known as “hsa-mir-4651” (miRBase Accession No. MI0017279, SEQ ID NO: 602) having a hairpin-like structure as a precursor.
  • hsa-miR-6813-5p gene or “hsa-miR-6813-5p” refers to the hsa-miR-6813-5p gene described in SEQ ID NO: 204 (miRBase Accession No. MIMAT0027526) and other species homologues or orthologues are included.
  • the hsa-miR-6813-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6813-5p” is known as “hsa-mir-6683” (miRBase Accession No. MI0022658, SEQ ID NO: 591) having a hairpin-like structure as a precursor.
  • hsa-miR-5787 gene or “hsa-miR-5787” refers to the hsa-miR-5787 gene (miRBase Accession No. MIMAT0023252) described in SEQ ID NO: 205 or other biological species. Homologs or orthologs are included. The hsa-miR-5787 gene was obtained from Yoo H et al., 2011, Biochem Biophys Res Commun. 415, 567-572. In addition, “hsa-miR-5787” is known as “hsa-mir-5787” (miRBase Accession No. MI0019797, SEQ ID NO: 603) having a hairpin-like structure as a precursor.
  • hsa-miR-1290 gene or “hsa-miR-1290” refers to the hsa-miR-1290 gene (miRBase Accession No. MIMAT0005880) described in SEQ ID NO: 206 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-1290 gene is described in Morin RD et al., 2008, Genome Res. 18, 610-621.
  • “Hsa-miR-1290” is known as “hsa-mir-1290” (miRBase Accession No. MI0006352, SEQ ID NO: 604) having a hairpin-like structure as a precursor.
  • hsa-miR-6075 gene or “hsa-miR-6075” refers to the hsa-miR-6075 gene (miRBase Accession No. MIMAT0023700) described in SEQ ID NO: 207 or other biological species. Homologs or orthologs are included. The hsa-miR-6075 gene was found in Voellenkle C et al., 2012, RNA. 18, 472-484. Also, “hsa-miR-6075” is known as “hsa-mir-6075” (miRBase Accession No. MI0020352, SEQ ID NO: 605) having a hairpin-like structure as a precursor.
  • hsa-miR-4758-5p gene or “hsa-miR-4758-5p” refers to the hsa-miR-4758-5p gene described in SEQ ID NO: 208 (miRBase Accession No. MIMAT0019903) and other species homologues or orthologues are included.
  • the hsa-miR-4758-5p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4758-5p “hsa-mir-4758” (miRBase Accession No. MI0017399, SEQ ID NO: 606) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4690-5p gene or “hsa-miR-4690-5p” refers to the hsa-miR-4690-5p gene described in SEQ ID NO: 209 (miRBase Accession No. MIMAT0019779) and other species homologs or orthologs.
  • the hsa-miR-4690-5p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4690-5p “hsa-mir-4690” (miRBase Accession No. MI0017323, SEQ ID NO: 607) having a hairpin-like structure as a precursor is known.
  • hsa-miR-762 gene or “hsa-miR-762” refers to the hsa-miR-762 gene (miRBase Accession No. MIMAT0010313) described in SEQ ID NO: 210 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-762 gene was obtained from Berezkov E et al., 2006, Genome Res. 16, Vol. 1629-1298.
  • hsa-miR-762 “hsa-mir-762” (miRBase Accession No. MI0003892, SEQ ID NO: 608) having a hairpin-like structure as a precursor is known.
  • hsa-miR-1225-3p gene or “hsa-miR-1225-3p” refers to the hsa-miR-1225-3p gene described in SEQ ID NO: 211 (miRBase Accession No. MIMAT0005573) and other species homologues or orthologues are included.
  • the hsa-miR-1225-3p gene was obtained from Berezikov E et al., 2007, Mol Cell. 28, 328-336.
  • “hsa-miR-1225-3p” is known as “hsa-mir-1225” (miRBase Accession No. MI0006311, SEQ ID NO: 609) having a hairpin-like structure as a precursor.
  • hsa-miR-3184-5p gene or “hsa-miR-3184-5p” refers to the hsa-miR-3184-5p gene (miRBase Accession No. MIMAT0015064) and other species homologs or orthologs.
  • the hsa-miR-3184-5p gene was obtained from Stark MS et al., 2010, PLoS One. No. 5, vol. E9685.
  • “Hsa-miR-3184-5p” is known as “hsa-mir-3184” (miRBase Accession No. MI0014226, SEQ ID NO: 398) having a hairpin-like structure as a precursor.
  • hsa-miR-665 gene or “hsa-miR-665” refers to the hsa-miR-665 gene (miRBase Accession No. MIMAT0004952) described in SEQ ID NO: 213 or other biological species. A homolog or ortholog is included.
  • the hsa-miR-665 gene was obtained from Berezikov E et al., 2006, Genome Res. 16, Vol. 1629-1298.
  • “Hsa-miR-665” is known as “hsa-mir-665” (miRBase Accession No. MI0005563, SEQ ID NO: 610) having a hairpin-like structure as a precursor.
  • hsa-miR-211-5p gene or “hsa-miR-211-5p” refers to the hsa-miR-211-5p gene described in SEQ ID NO: 214 (miRBase Accession No. MIMAT0000268) and other species homologues or orthologues are included.
  • the hsa-miR-211-5p gene is described in Lim LP et al., 2003, Science. 299, 1540.
  • hsa-mir-211 miRBase Accession No. MI000027, SEQ ID NO: 611 having a hairpin-like structure as a precursor is known.
  • hsa-miR-1247-5p gene or “hsa-miR-1247-5p” refers to the hsa-miR-1247-5p gene described in SEQ ID NO: 215 (miRBase Accession No. MIMAT0005899) and other species homologues or orthologues are included.
  • the hsa-miR-1247-5p gene is described in Morin RD et al., 2008, Genome Res. 18, 610-621.
  • “hsa-miR-1247-5p” is known as “hsa-mir-1247” (miRBase Accession No. MI0006382, SEQ ID NO: 489) having a hairpin-like structure as a precursor.
  • hsa-miR-3656 gene or “hsa-miR-3656” refers to the hsa-miR-3656 gene (miRBase Accession No. MIMAT0018076) described in SEQ ID NO: 216 or other biological species. Homologs or orthologs are included. The hsa-miR-3656 gene was found in Meiri E et al., 2010, Nucleic Acids Res. 38, 6234-6246. As for “hsa-miR-3656”, “hsa-mir-3656” (miRBase Accession No. MI0016056, SEQ ID NO: 612) having a hairpin-like structure as a precursor is known.
  • hsa-miR-149-5p gene or “hsa-miR-149-5p” refers to the hsa-miR-149-5p gene described in SEQ ID NO: 217 (miRBase Accession No. MIMAT000050) and other species homologs or orthologs.
  • the hsa-miR-149-5p gene was obtained from Lagos-Quintana M et al., 2002, Curr Biol. 12, Vol. 735-739.
  • hsa-miR-149-5p “hsa-mir-149” (miRBase Accession No. MI0000478, SEQ ID NO: 613) having a hairpin-like structure as a precursor is known.
  • hsa-miR-744-5p gene or “hsa-miR-744-5p” refers to the hsa-miR-744-5p gene described in SEQ ID NO: 218 (miRBase Accession No. MIMAT0004945) and other species homologs or orthologs.
  • the hsa-miR-744-5p gene was obtained from Berezikov E et al., 2006, Genome Res. 16, Vol. 1629-1298.
  • hsa-miR-744-5p is known as “hsa-mir-744” (miRBase Accession No. MI0005559, SEQ ID NO: 614) having a hairpin-like structure as a precursor.
  • hsa-miR-345-5p gene or “hsa-miR-345-5p” refers to the hsa-miR-345-5p gene described in SEQ ID NO: 219 (miRBase Accession No. MIMAT0000772) and other species homologs or orthologs.
  • the hsa-miR-345-5p gene was found in Kim J et al., 2004, Proc Natl Acad Sci U SA. 101, 360-365.
  • hsa-mir-345 (miRBase Accession No. MI000025, SEQ ID NO: 615) having a hairpin-like structure as a precursor is known.
  • hsa-miR-150-5p gene or “hsa-miR-150-5p” refers to the hsa-miR-150-5p gene described in SEQ ID NO: 220 (miRBase Accession No. MIMAT0000451) and other species homologues or orthologues are included.
  • the hsa-miR-150-5p gene was obtained from Lagos-Quintana M et al., 2002, Curr Biol. 12, Vol. 735-739.
  • “hsa-miR-150-5p” is known as “hsa-mir-150” (miRBase Accession No. MI000079, SEQ ID NO: 616) having a hairpin-like structure as a precursor.
  • hsa-miR-191-3p gene or “hsa-miR-191-3p” refers to the hsa-miR-191-3p gene described in SEQ ID NO: 221 (miRBase Accession No. MIMAT001618) and other species homologs or orthologs.
  • the hsa-miR-191-3p gene was obtained from Lagos-Quintana M et al., 2003, RNA. 9, 175-179.
  • “hsa-miR-191-3p” is known as “hsa-mir-191” (miRBase Accession No. MI000065, SEQ ID NO: 617) having a hairpin-like structure as a precursor.
  • hsa-miR-651-5p gene or “hsa-miR-651-5p” refers to the hsa-miR-651-5p gene (miRBase Accession No. MIMAT0003321) and other species homologues or orthologues are included.
  • the hsa-miR-651-5p gene was found in Cummins JM et al., 2006, Proc Natl Acad Sci USA. 103, 3687-3692.
  • “hsa-miR-651-5p” is known as “hsa-mir-651” (miRBase Accession No. MI0003666, SEQ ID NO: 618) having a hairpin-like structure as a precursor.
  • hsa-miR-34a-5p gene or “hsa-miR-34a-5p” refers to the hsa-miR-34a-5p gene described in SEQ ID NO: 223 (miRBase Accession No. MIMAT 0000255) and other species homologs or orthologs.
  • the hsa-miR-34a-5p gene is disclosed in Dostie J et al., 2003, RNA. 9, Vol. 180-186.
  • hsa-mir-34a (miRBase Accession No. MI0000268, SEQ ID NO: 619) having a hairpin-like structure as a precursor is known.
  • hsa-miR-409-5p gene or “hsa-miR-409-5p” refers to the hsa-miR-409-5p gene described in SEQ ID NO: 224 (miRBase Accession No. MIMAT001638) and other species homologs or orthologs.
  • the hsa-miR-409-5p gene was obtained from Altvia Y et al., 2005, Nucleic Acids Res. 33, 2697-2706.
  • “hsa-miR-409-5p” is known as “hsa-mir-409” (miRBase Accession No. MI0001735, SEQ ID NO: 620) having a hairpin-like structure as a precursor.
  • hsa-miR-369-5p gene or “hsa-miR-369-5p” refers to the hsa-miR-369-5p gene described in SEQ ID NO: 225 (miRBase Accession No. MIMAT0001621) and other species homologs or orthologs are included.
  • the hsa-miR-369-5p gene was obtained from Suh MR et al., 2004, Dev Biol. 270, 488-498.
  • hsa-miR-369-5p “hsa-mir-369” (miRBase Accession No. MI000077, SEQ ID NO: 621) having a hairpin-like structure as a precursor is known.
  • hsa-miR-1915-5p gene or “hsa-miR-1915-5p” refers to the hsa-miR-1915-5p gene described in SEQ ID NO: 226 (miRBase Accession No. MIMAT0007891) and other species homologues or orthologues are included.
  • the hsa-miR-1915-5p gene is described in Bar M et al., 2008, Stem Cells. 26, 2496-2505.
  • “hsa-miR-1915-5p” is known as “hsa-mir-1915” (miRBase Accession No. MI0008336, SEQ ID NO: 594) having a hairpin-like structure as a precursor.
  • hsa-miR-204-5p gene or “hsa-miR-204-5p” refers to the hsa-miR-204-5p gene described in SEQ ID NO: 227 (miRBase Accession No. MIMAT0000265) and other species homologues or orthologues are included.
  • the hsa-miR-204-5p gene is described in Lim LP et al., 2003, Science. 299, 1540.
  • “hsa-miR-204-5p” is known as “hsa-mir-204” (miRBase Accession No. MI00000028, SEQ ID NO: 622) having a hairpin-like structure as a precursor.
  • hsa-miR-137 gene or “hsa-miR-137” refers to the hsa-miR-137 gene (miRBase Accession No. MIMAT000029) described in SEQ ID NO: 228 or other species. Homologs or orthologs are included.
  • the hsa-miR-137 gene was obtained from Lagos-Quintana M et al., 2002, Curr Biol. 12, Vol. 735-739.
  • “hsa-miR-137” is known as “hsa-mir-137” (miRBase Accession No. MI0000454, SEQ ID NO: 623) having a hairpin-like structure as a precursor.
  • hsa-miR-382-5p gene or “hsa-miR-382-5p” refers to the hsa-miR-382-5p gene described in SEQ ID NO: 229 (miRBase Accession No. MIMAT0000737) and other species homologs or orthologs.
  • the hsa-miR-382-5p gene was obtained from Altvia Y et al., 2005, Nucleic Acids Res. 33, 2697-2706.
  • hsa-miR-382-5p “hsa-mir-382” (miRBase Accession No. MI000070, SEQ ID NO: 624) having a hairpin-like structure as a precursor is known.
  • hsa-miR-517-5p gene or “hsa-miR-517-5p” refers to the hsa-miR-517-5p gene described in SEQ ID NO: 230 (miRBase Accession No. MIMAT0002851) and other species homologues or orthologues are included.
  • the hsa-miR-517-5p gene was obtained from Bentwich I et al., 2005, Nat Genet. 37, 766-770.
  • “hsa-miR-517-5p” is known as “hsa-mir-517c” (miRBase Accession No. MI0003174, SEQ ID NO: 625) having a hairpin-like structure as a precursor.
  • hsa-miR-532-5p gene or “hsa-miR-532-5p” refers to the hsa-miR-532-5p gene described in SEQ ID NO: 231 (miRBase Accession No. MIMAT0002888) and other species homologs or orthologs.
  • the hsa-miR-532-5p gene is described in Lagos-Quintana M et al., 2001, Science. 294, 853-858.
  • hsa-miR-532-5p “hsa-mir-532” (miRBase Accession No. MI0003205, SEQ ID NO: 626) having a hairpin-like structure as a precursor is known.
  • hsa-miR-22-5p gene or “hsa-miR-22-5p” refers to the hsa-miR-22-5p gene described in SEQ ID NO: 232 (miRBase Accession No. MIMAT0004495) and other species homologs or orthologs.
  • the hsa-miR-22-5p gene was obtained from Berezikov E et al., 2007, Mol Cell. 28, 328-336.
  • hsa-miR-22-5p is known as “hsa-mir-22” (miRBase Accession No. MI0000078, SEQ ID NO: 627) having a hairpin-like structure as a precursor.
  • hsa-miR-1237-3p gene or “hsa-miR-1237-3p” refers to the hsa-miR-1237-3p gene described in SEQ ID NO: 233 (miRBase Accession No. MIMAT0005592) and other species homologs or orthologs.
  • the hsa-miR-1237-3p gene is described in Berezikov E et al., 2006, Genome Res. 16, Vol. 1629-1298.
  • hsa-mir-1237 (miRBase Accession No. MI0006327, SEQ ID NO: 628) having a hairpin-like structure as a precursor is known.
  • hsa-miR-1224-3p gene or “hsa-miR-1224-3p” refers to the hsa-miR-1224-3p gene described in SEQ ID NO: 234 (miRBase Accession No. MIMAT0005459) and other species homologs or orthologs.
  • the hsa-miR-1224-3p gene was found in Cummins JM et al., 2006, Proc Natl Acad Sci USA. 103, 3687-3692.
  • hsa-miR-1224-3p “hsa-mir-1224” (miRBase Accession No. MI0003764, SEQ ID NO: 629) having a hairpin-like structure as a precursor is known.
  • hsa-miR-625-3p gene or “hsa-miR-625-3p” refers to the hsa-miR-625-3p gene described in SEQ ID NO: 235 (miRBase Accession No. MIMAT0004808) and other species homologues or orthologues are included.
  • the hsa-miR-625-3p gene was found in Kim J et al., 2004, Proc Natl Acad Sci USA. 101, 360-365.
  • “hsa-miR-625-3p” is known as “hsa-mir-625” (miRBase Accession No. MI0003639, SEQ ID NO: 630) having a hairpin-like structure as a precursor.
  • hsa-miR-328-3p gene or “hsa-miR-328-3p” refer to the hsa-miR-328-3p gene described in SEQ ID NO: 236 (miRBase Accession No. MIMAT0000752) and other species homologs or orthologs.
  • the hsa-miR-328-3p gene was obtained from Lagos-Quintana M et al., 2002, Curr Biol. 12, Vol. 735-739.
  • “hsa-miR-328-3p” is known as “hsa-mir-328” (miRBase Accession No. MI000004, SEQ ID NO: 631) having a hairpin-like structure as a precursor.
  • hsa-miR-122-5p gene or “hsa-miR-122-5p” refers to the hsa-miR-122-5p gene described in SEQ ID NO: 237 (miRBase Accession No. MIMAT000021) and other species homologues or orthologues are included.
  • the hsa-miR-122-5p gene was obtained from Bentwich I et al., 2005, Nat Genet. 37, 766-770.
  • “hsa-miR-122-5p” is known as “hsa-mir-122” (miRBase Accession No. MI000042, SEQ ID NO: 632) having a hairpin-like structure as a precursor.
  • hsa-miR-202-3p gene or “hsa-miR-202-3p” refers to the hsa-miR-202-3p gene described in SEQ ID NO: 238 (miRBase Accession No. MIMAT0002811) and other species homologues or orthologues are included.
  • the hsa-miR-202-3p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • “hsa-miR-202-3p” is known as “hsa-mir-202” (miRBase Accession No. MI0003130, SEQ ID NO: 485) having a hairpin-like structure as a precursor.
  • hsa-miR-4781-5p gene or “hsa-miR-4781-5p” refers to the hsa-miR-4781-5p gene described in SEQ ID NO: 239 (miRBase Accession No. MIMAT0019942) and other species homologues or orthologues are included.
  • the hsa-miR-4781-5p gene was obtained from Artzi S et al., 2008, BMC Bioinformatics. , 9, 39.
  • “hsa-miR-4781-5p” is known as “hsa-mir-4781” (miRBase Accession No. MI0017426, SEQ ID NO: 633) having a hairpin-like structure as a precursor.
  • hsa-miR-718 gene or “hsa-miR-718” refers to the hsa-miR-718 gene (miRBase Accession No. MIMAT0012735) described in SEQ ID NO: 240 or other biological species. Homologs or orthologs are included. The hsa-miR-718 gene was found in Kim J et al., 2004, Proc Natl Acad Sci US A. 101, 360-365. Also, “hsa-miR-718” is known as “hsa-mir-718” (miRBase Accession No. MI0012489, SEQ ID NO: 634) having a hairpin-like structure as a precursor.
  • hsa-miR-342-3p gene or “hsa-miR-342-3p” refers to the hsa-miR-342-3p gene described in SEQ ID NO: 241 (miRBase Accession No. MIMAT000053) and other species homologues or orthologues are included.
  • the hsa-miR-342-3p gene is described in Lagos-Quintana M et al., 2001, Science. 294, 853-858.
  • hsa-miR-342-3p “hsa-mir-342” (miRBase Accession No. MI000005, SEQ ID NO: 635) having a hairpin-like structure as a precursor is known.
  • hsa-miR-26b-3p gene or “hsa-miR-26b-3p” refers to the hsa-miR-26b-3p gene described in SEQ ID NO: 242 (miRBase Accession No. MIMAT0004500) and other species homologs or orthologs.
  • the hsa-miR-26b-3p gene was obtained from Lagos-Quintana M et al., 2002, Curr Biol. 12, Vol. 735-739.
  • hsa-miR-26b-3p “hsa-mir-26b” (miRBase Accession No. MI0000084, SEQ ID NO: 636) having a hairpin-like structure as a precursor is known.
  • hsa-miR-140-3p gene or “hsa-miR-140-3p” refer to the hsa-miR-140-3p gene described in SEQ ID NO: 243 (miRBase Accession No. MIMAT0004597) and other species homologues or orthologues are included.
  • the hsa-miR-140-3p gene was obtained from Lagos-Quintana M et al., 2003, RNA. 9, 175-179.
  • hsa-mir-140 (miRBase Accession No. MI000056, SEQ ID NO: 637) having a hairpin-like structure as a precursor is known.
  • hsa-miR-200a-3p gene or “hsa-miR-200a-3p” refers to the hsa-miR-200a-3p gene described in SEQ ID NO: 244 (miRBase Accession No. MIMAT000002) and other species homologues or orthologues are included.
  • the hsa-miR-200a-3p gene was found in Kasshima K et al., 2004, Biochem Biophys Res Commun. 322, 403-410.
  • “hsa-miR-200a-3p” is known as “hsa-mir-200a” (miRBase Accession No. MI0000737, SEQ ID NO: 638) having a hairpin-like structure as a precursor.
  • hsa-miR-378a-3p gene or “hsa-miR-378a-3p” refers to the hsa-miR-378a-3p gene described in SEQ ID NO: 245 (miRBase Accession No. MIMAT000072) and other species homologues or orthologues are included.
  • the hsa-miR-378a-3p gene was obtained from Fu H et al., 2005, FEBS Lett. 579, 3849-3854.
  • “hsa-miR-378a-3p” is known as “hsa-mir-378a” (miRBase Accession No. MI000086, SEQ ID NO: 639) having a hairpin-like structure as a precursor.
  • hsa-miR-484 gene or “hsa-miR-484” refers to the hsa-miR-484 gene (miRBase Accession No. MIMAT0002174) described in SEQ ID NO: 246 or other biological species. Homologs or orthologs are included. The hsa-miR-484 gene was obtained from Houbevy HB et al., 2003, Dev Cell. No. 5, 351-358. As for “hsa-miR-484”, “hsa-mir-484” (miRBase Accession No. MI0002468, SEQ ID NO: 640) having a hairpin-like structure as a precursor is known.
  • hsa-miR-296-5p gene or “hsa-miR-296-5p” refers to the hsa-miR-296-5p gene described in SEQ ID NO: 247 (miRBase Accession No. MIMAT060690) and other species homologues or orthologues are included.
  • the hsa-miR-296-5p gene is described in Lim LP et al., 2003, Science. 299, 1540.
  • “hsa-miR-296-5p” is known as “hsa-mir-296” (miRBase Accession No. MI000047, SEQ ID NO: 641) having a hairpin-like structure as a precursor.
  • hsa-miR-205-5p gene or “hsa-miR-205-5p” refers to the hsa-miR-205-5p gene described in SEQ ID NO: 248 (miRBase Accession No. MIMAT0000266) and other species homologs or orthologs.
  • the hsa-miR-205-5p gene was obtained from Altvia Y et al., 2005, Nucleic Acids Res. 33, 2697-2706.
  • “hsa-miR-205-5p” is known as “hsa-mir-205” (miRBase Accession No. MI00000028, SEQ ID NO: 642) having a hairpin-like structure as a precursor.
  • hsa-miR-431-5p gene or “hsa-miR-431-5p” refers to the hsa-miR-431-5p gene described in SEQ ID NO: 249 (miRBase Accession No. MIMAT001625) and other species homologs or orthologs.
  • the hsa-miR-431-5p gene was obtained from Kawaji H et al., 2008, BMC Genomics. , Vol. 9, 157.
  • hsa-mir-431 miRBase Accession No. MI0001721, SEQ ID NO: 643 having a hairpin-like structure as a precursor is known.
  • hsa-miR-1471 gene or “hsa-miR-1471” refers to the hsa-miR-1471 gene (miRBase Accession No. MIMAT0007349) described in SEQ ID NO: 250 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-1471 gene was obtained from Azuma-Mukai A et al., 2008, Proc Natl Acad Sci US A. 105, 7964-7969.
  • hsa-miR-1471 “hsa-mir-1471” (miRBase Accession No. MI00000076, SEQ ID NO: 644) having a hairpin-like structure as a precursor is known.
  • hsa-miR-1538 gene or “hsa-miR-1538” refers to the hsa-miR-1538 gene (miRBase Accession No. MIMAT0007400) described in SEQ ID NO: 251 and other biological species. Homologs or orthologs are included. The hsa-miR-1538 gene was found in Cummins JM et al., 2006, Proc Natl Acad Sci USA. 103, 3687-3692. “Hsa-miR-1538” is known as “hsa-mir-1538” (miRBase Accession No. MI0007259, SEQ ID NO: 645), which has a hairpin-like structure as a precursor.
  • hsa-miR-449b-3p gene or “hsa-miR-449b-3p” refers to the hsa-miR-449b-3p gene described in SEQ ID NO: 252 (miRBase Accession No. MIMAT0009203) and other species homologues or orthologues are included.
  • the hsa-miR-449b-3p gene was obtained from Schotte D et al., 2009, Leukemia. , Volume 23, 313-322.
  • hsa-mir-449b (miRBase Accession No. MI0003673, SEQ ID NO: 646) having a hairpin-like structure as a precursor is known.
  • hsa-miR-1976 gene or “hsa-miR-1976” refers to the hsa-miR-1976 gene (miRBase Accession No. MIMAT0009451) described in SEQ ID NO: 253 or other biological species. Homologs or orthologs are included. The hsa-miR-1976 gene was found in Goff LA et al., 2009, PLoS One. 4, Volume 4, e7192. As for “hsa-miR-1976”, “hsa-mir-1976” (miRBase Accession No. MI0009986, SEQ ID NO: 647) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4268 gene or “hsa-miR-4268” refers to the hsa-miR-4268 gene (miRBase Accession No. MIMAT0016896) described in SEQ ID NO: 254 and other biological species. Homologs or orthologs are included. The hsa-miR-4268 gene was found in Goff LA et al., 2009, PLoS One. 4, Volume 4, e7192. Also, “hsa-miR-4268” is known as “hsa-mir-4268” (miRBase Accession No. MI0015874, SEQ ID NO: 648) having a hairpin-like structure as a precursor.
  • hsa-miR-4279 gene or “hsa-miR-4279” refers to the hsa-miR-4279 gene (miRBase Accession No. MIMAT0016909) described in SEQ ID NO: 255 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-4279 gene was obtained from Witten D et al., 2010, BMC Biol. , 8, 58.
  • hsa-mir-4279 miRBase Accession No. MI0015887, SEQ ID NO: 649) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3620-3p gene or “hsa-miR-3620-3p” refers to the hsa-miR-3620-3p gene described in SEQ ID NO: 256 (miRBase Accession No. MIMAT0018001) and other species homologues or orthologues are included.
  • the hsa-miR-3620-3p gene was obtained from Witten D et al., 2010, BMC Biol. , 8, 58.
  • “hsa-miR-3620-3p” is known as “hsa-mir-3620” (miRBase Accession No. MI0016011, SEQ ID NO: 650) having a hairpin-like structure as a precursor.
  • hsa-miR-3944-3p gene or “hsa-miR-3944-3p” refers to the hsa-miR-3944-3p gene described in SEQ ID NO: 257 (miRBase Accession No. MIMAT0018360) and other species homologues or orthologues are included.
  • the hsa-miR-3944-3p gene was obtained from Liao JY et al., 2010, PLoS One. 5, Vol. 5, e10563.
  • “hsa-miR-3944-3p” is known as “hsa-mir-3944” (miRBase Accession No. MI0016601, SEQ ID NO: 651) having a hairpin-like structure as a precursor.
  • hsa-miR-3156-3p gene or “hsa-miR-3156-3p” refers to the hsa-miR-3156-3p gene described in SEQ ID NO: 258 (miRBase Accession No. MIMAT0019209) and other species homologues or orthologues are included.
  • the hsa-miR-3156-3p gene was obtained from Stark MS et al., 2010, PLoS One. No. 5, vol. E9685.
  • “Hsa-miR-3156-3p” has a hairpin-like structure as its precursor, “hsa-mir-3156-1, hsa-mir-3156-2” (miRBase Accession No. MI0014184, MI0014230, SEQ ID NO: 652, 653) is known.
  • hsa-miR-3187-5p gene or “hsa-miR-3187-5p” refers to the hsa-miR-3187-5p gene described in SEQ ID NO: 259 (miRBase Accession No. MIMAT0019216) and other species homologs or orthologs are included.
  • the hsa-miR-3187-5p gene was obtained from Stark MS et al., 2010, PLoS One. No. 5, vol. E9685.
  • “hsa-miR-3187-5p” is known as “hsa-mir-3187” (miRBase Accession No. MI0014231, SEQ ID NO: 654) having a hairpin-like structure as a precursor.
  • hsa-miR-4665-3p gene or “hsa-miR-4687-3p” refers to the hsa-miR-4665-3p gene (miRBase Accession No. MIMAT0019772) and other species homologues or orthologues are included.
  • the hsa-miR-4485-3p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • “hsa-miR-4585-3p” is known as “hsa-mir-4485” (miRBase Accession No. MI0017317, SEQ ID NO: 655) having a hairpin-like structure as a precursor.
  • hsa-miR-4695-3p gene or “hsa-miR-4695-3p” refers to the hsa-miR-4695-3p gene described in SEQ ID NO: 261 (miRBase Accession No. MIMAT0019789) and other species homologues or orthologues are included.
  • the hsa-miR-4695-3p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4695-3p “hsa-mir-4695” (miRBase Accession No. MI0017328, SEQ ID NO: 656) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4697-3p gene or “hsa-miR-4697-3p” refers to the hsa-miR-4697-3p gene described in SEQ ID NO: 262 (miRBase Accession No. MIMAT0019792) and other species homologues or orthologues are included.
  • the hsa-miR-4697-3p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4697-3p “hsa-mir-4697” (miRBase Accession No. MI0017330, SEQ ID NO: 657) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4713-5p gene or “hsa-miR-4713-5p” refers to the hsa-miR-4713-5p gene described in SEQ ID NO: 263 (miRBase Accession No. MIMAT0019820) and other species homologues or orthologues are included.
  • the hsa-miR-4713-5p gene is described in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4713-5p “hsa-mir-4713” (miRBase Accession No. MI0017347, SEQ ID NO: 658) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4723-3p gene or “hsa-miR-4723-3p” refers to the hsa-miR-4723-3p gene described in SEQ ID NO: 264 (miRBase Accession No. MIMAT0019839) and other species homologs or orthologs.
  • the hsa-miR-4723-3p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4723-3p “hsa-mir-4723” (miRBase Accession No. MI0017359, SEQ ID NO: 659) having a hairpin-like structure as a precursor is known.
  • hsa-miR-371b-3p gene or “hsa-miR-371b-3p” refers to the hsa-miR-371b-3p gene described in SEQ ID NO: 265 (miRBase Accession No. MIMAT0019893) and other species homologs or orthologs are included.
  • the hsa-miR-371b-3p gene is described in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-371b-3p “hsa-mir-371b” (miRBase Accession No. MI0017393, SEQ ID NO: 660) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3151-3p gene or “hsa-miR-3151-3p” refers to the hsa-miR-3151-3p gene described in SEQ ID NO: 266 (miRBase Accession No. MIMAT0027026) and other species homologues or orthologues are included.
  • the hsa-miR-3151-3p gene was obtained from Stark MS et al., 2010, PLoS One. No. 5, vol. E9685.
  • “hsa-miR-3151-3p” is known as “hsa-mir-3151” (miRBase Accession No. MI0014178, SEQ ID NO: 661) having a hairpin-like structure as a precursor.
  • hsa-miR-3192-3p gene or “hsa-miR-3192-3p” refers to the hsa-miR-3192-3p gene described in SEQ ID NO: 267 (miRBase Accession No. MIMAT0027027) and other species homologs or orthologs.
  • the hsa-miR-3192-3p gene was obtained from Stark MS et al., 2010, PLoS One. No. 5, vol. E9685.
  • “hsa-miR-3192-3p” is known as “hsa-mir-3192” (miRBase Accession No. MI0014237, SEQ ID NO: 662) having a hairpin-like structure as a precursor.
  • hsa-miR-6728-3p gene or “hsa-miR-6728-3p” refers to the hsa-miR-6728-3p gene described in SEQ ID NO: 268 (miRBase Accession No. MIMAT0027358) and other species homologues or orthologues are included.
  • the hsa-miR-6728-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6728-3p” is known as “hsa-mir-6728” (miRBase Accession No. MI0022573, SEQ ID NO: 663) having a hairpin-like structure as a precursor.
  • hsa-miR-6736-3p gene or “hsa-miR-6736-3p” refers to the hsa-miR-6736-3p gene described in SEQ ID NO: 269 (miRBase Accession No. MIMAT0027374) and other species homologues or orthologues are included.
  • the hsa-miR-6736-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6736-3p” is known as “hsa-mir-6736” (miRBase Accession No. MI0022581, SEQ ID NO: 664) having a hairpin-like structure as a precursor.
  • hsa-miR-6740-3p gene or “hsa-miR-6740-3p” refers to the hsa-miR-6740-3p gene described in SEQ ID NO: 270 (miRBase Accession No. MIMAT0027382) and other species homologues or orthologues are included.
  • the hsa-miR-6740-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6740-3p” is known as “hsa-mir-6740” (miRBase Accession No. MI0022585, SEQ ID NO: 665) having a hairpin-like structure as a precursor.
  • hsa-miR-6741-3p gene or “hsa-miR-6741-3p” refers to the hsa-miR-6741-3p gene described in SEQ ID NO: 271 (miRBase Accession No. MIMAT0027384) and other species homologues or orthologues are included.
  • the hsa-miR-6741-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6741-3p” is known as “hsa-mir-6741” (miRBase Accession No. MI0022586, SEQ ID NO: 666) having a hairpin-like structure as a precursor.
  • hsa-miR-6743-3p gene or “hsa-miR-6743-3p” refers to the hsa-miR-6743-3p gene (miRBase Accession No. MIMAT0027388) and other species homologs or orthologs.
  • the hsa-miR-6743-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6743-3p “hsa-mir-6743” (miRBase Accession No. MI0022588, SEQ ID NO: 599) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6747-3p gene or “hsa-miR-6747-3p” refers to the hsa-miR-6747-3p gene described in SEQ ID NO: 273 (miRBase Accession No. MIMAT0027395) and other species homologues or orthologues are included.
  • the hsa-miR-6747-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6747-3p “hsa-mir-6747” (miRBase Accession No. MI0022592, SEQ ID NO: 667) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6750-3p gene or “hsa-miR-6750-3p” refers to the hsa-miR-6750-3p gene described in SEQ ID NO: 274 (miRBase Accession No. MIMAT0027401) and other species homologs or orthologs.
  • the hsa-miR-6750-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6750-3p” is known as “hsa-mir-6750” (miRBase Accession No. MI0022595, SEQ ID NO: 668) having a hairpin-like structure as a precursor.
  • hsa-miR-6754-3p gene or “hsa-miR-6754-3p” refers to the hsa-miR-6754-3p gene described in SEQ ID NO: 275 (miRBase Accession No. MIMAT0027409) and other species homologues or orthologues are included.
  • the hsa-miR-6754-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6754-3p” is known as “hsa-mir-6754” (miRBase Accession No. MI0022599, SEQ ID NO: 669) having a hairpin-like structure as a precursor.
  • hsa-miR-6759-3p gene or “hsa-miR-6759-3p” refers to the hsa-miR-6759-3p gene described in SEQ ID NO: 276 (miRBase Accession No. MIMAT0027419) and other species homologues or orthologues are included.
  • the hsa-miR-6759-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6759-3p “hsa-mir-6759” (miRBase Accession No. MI0022604, SEQ ID NO: 670) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6761-3p gene or “hsa-miR-6761-3p” refers to the hsa-miR-6761-3p gene described in SEQ ID NO: 277 (miRBase Accession No. MIMAT0027423) and other species homologs or orthologs.
  • the hsa-miR-6761-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6761-3p” is known as “hsa-mir-6761” (miRBase Accession No. MI0022606, SEQ ID NO: 671) having a hairpin-like structure as a precursor.
  • hsa-miR-6762-3p gene or “hsa-miR-6762-3p” refers to the hsa-miR-6762-3p gene described in SEQ ID NO: 278 (miRBase Accession No. MIMAT0027425) and other species homologues or orthologues are included.
  • the hsa-miR-6762-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6762-3p” is known as “hsa-mir-6762” (miRBase Accession No. MI0022607, SEQ ID NO: 672) having a hairpin-like structure as a precursor.
  • hsa-miR-6769a-3p gene or “hsa-miR-6769a-3p” refer to the hsa-miR-6769a-3p gene described in SEQ ID NO: 279 (miRBase Accession No. MIMAT0027439) and other species homologues or orthologues are included.
  • the hsa-miR-6769a-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6769a-3p “hsa-mir-6769a” (miRBase Accession No. MI0022614, SEQ ID NO: 673), which has a hairpin-like structure as a precursor, is known.
  • hsa-miR-6766-3p gene or “hsa-miR-6766-3p” refers to the hsa-miR-6766-3p gene (miRBase Accession No. MIMAT0027453) and other species homologues or orthologues are included.
  • the hsa-miR-6767-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6766p is known as “hsa-mir-6766” (miRBase Accession No. MI0022621, SEQ ID NO: 674) having a hairpin-like structure as a precursor.
  • hsa-miR-6778-3p gene or “hsa-miR-6778-3p” refers to the hsa-miR-6778-3p gene described in SEQ ID NO: 281 (miRBase Accession No. MIMAT0027457) and other species homologues or orthologues are included.
  • the hsa-miR-6778-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6778-3p “hsa-mir-6778” (miRBase Accession No. MI0022623, SEQ ID NO: 675) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6679-3p gene or “hsa-miR-6779-3p” refers to the hsa-miR-6679-3p gene described in SEQ ID NO: 282 (miRBase Accession No. MIMAT0027459) and other species homologs or orthologs.
  • the hsa-miR-6679-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6779-3p” is known as “hsa-mir-6679” (miRBase Accession No. MI0022624, SEQ ID NO: 676) having a hairpin-like structure as a precursor.
  • hsa-miR-6786-3p gene or “hsa-miR-6786-3p” refers to the hsa-miR-6786-3p gene described in SEQ ID NO: 283 (miRBase Accession No. MIMAT0027473) and other species homologues or orthologues are included.
  • the hsa-miR-6786-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6786-3p “hsa-mir-6786” (miRBase Accession No. MI0022631, SEQ ID NO: 539) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6787-3p gene or “hsa-miR-6787-3p” refers to the hsa-miR-6787-3p gene described in SEQ ID NO: 284 (miRBase Accession No. MIMAT0027475) and other species homologs or orthologs.
  • the hsa-miR-6787-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6787-3p “hsa-mir-6787” (miRBase Accession No. MI0022632, SEQ ID NO: 677) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6792-3p gene or “hsa-miR-6792-3p” refers to the hsa-miR-6792-3p gene described in SEQ ID NO: 285 (miRBase Accession No. MIMAT0027485) and other species homologues or orthologues are included.
  • the hsa-miR-6792-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6792-3p “hsa-mir-6792” (miRBase Accession No. MI0022637, SEQ ID NO: 678) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6794-3p gene or “hsa-miR-6794-3p” refers to the hsa-miR-6794-3p gene described in SEQ ID NO: 286 (miRBase Accession No. MIMAT0027489) and other species homologs or orthologs.
  • the hsa-miR-6794-3p gene was found in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6794-3p “hsa-mir-6794” (miRBase Accession No. MI0022639, SEQ ID NO: 679) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6801-3p gene or “hsa-miR-6801-3p” refers to the hsa-miR-6801-3p gene described in SEQ ID NO: 287 (miRBase Accession No. MIMAT0027503) and other species homologues or orthologues are included.
  • the hsa-miR-6801-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6801-3p “hsa-mir-6801” (miRBase Accession No. MI0022646, SEQ ID NO: 680) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6802-3p gene or “hsa-miR-6802-3p” refers to the hsa-miR-6802-3p gene described in SEQ ID NO: 288 (miRBase Accession No. MIMAT0027505) and other species homologues or orthologues are included.
  • the hsa-miR-6802-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6802-3p” is known as “hsa-mir-6802” (miRBase Accession No. MI0022647, SEQ ID NO: 681) having a hairpin-like structure as a precursor.
  • hsa-miR-6803-3p gene or “hsa-miR-6803-3p” refers to the hsa-miR-6803-3p gene described in SEQ ID NO: 289 (miRBase Accession No. MIMAT0027507) and other species homologues or orthologues are included.
  • the hsa-miR-6803-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6803-3p” is known as “hsa-mir-6803” (miRBase Accession No. MI0022648, SEQ ID NO: 682) having a hairpin-like structure as a precursor.
  • hsa-miR-6804-3p gene or “hsa-miR-6804-3p” refers to the hsa-miR-6804-3p gene described in SEQ ID NO: 290 (miRBase Accession No. MIMAT0027509) and other species homologues or orthologues are included.
  • the hsa-miR-6804-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6804-3p “hsa-mir-6804” (miRBase Accession No. MI0022649, SEQ ID NO: 683) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6810-5p gene or “hsa-miR-6810-5p” refers to the hsa-miR-6810-5p gene described in SEQ ID NO: 291 (miRBase Accession No. MIMAT0027520) and other species homologues or orthologues are included.
  • the hsa-miR-6810-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6810-5p “hsa-mir-6810” (miRBase Accession No. MI0022655, SEQ ID NO: 684) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6823-3p gene or “hsa-miR-6823-3p” refers to the hsa-miR-6823-3p gene described in SEQ ID NO: 292 (miRBase Accession No. MIMAT0027547) and other species homologues or orthologues are included.
  • the hsa-miR-6823-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6823-3p “hsa-mir-6823” (miRBase Accession No. MI0022668, SEQ ID NO: 550) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6825-3p gene or “hsa-miR-6825-3p” refers to the hsa-miR-6825-3p gene described in SEQ ID NO: 293 (miRBase Accession No. MIMAT0027551) and other species homologues or orthologues are included.
  • the hsa-miR-6825-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6825-3p “hsa-mir-6825” (miRBase Accession No. MI0022670, SEQ ID NO: 685) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6829-3p gene or “hsa-miR-6829-3p” refers to the hsa-miR-6829-3p gene described in SEQ ID NO: 294 (miRBase Accession No. MIMAT0027559) and other species homologues or orthologues are included.
  • the hsa-miR-6829-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6829-3p “hsa-mir-6829” (miRBase Accession No. MI0022674, SEQ ID NO: 686) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6833-3p gene or “hsa-miR-6833-3p” refers to the hsa-miR-6833-3p gene described in SEQ ID NO: 295 (miRBase Accession No. MIMAT0027567) and other species homologues or orthologues are included.
  • the hsa-miR-6833-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6833-3p” is known as “hsa-mir-6833” (miRBase Accession No. MI0022678, SEQ ID NO: 687) having a hairpin-like structure as a precursor.
  • hsa-miR-6835-3p gene or “hsa-miR-6834-3p” refers to the hsa-miR-6835-3p gene described in SEQ ID NO: 296 (miRBase Accession No. MIMAT0027569) and other species homologs or orthologs are included.
  • the hsa-miR-6835-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6834p” is known as “hsa-mir-6683” (miRBase Accession No. MI0022679, SEQ ID NO: 688) having a hairpin-like structure as a precursor.
  • hsa-miR-6780b-3p gene or “hsa-miR-6780b-3p” refers to the hsa-miR-6780b-3p gene described in SEQ ID NO: 297 (miRBase Accession No. MIMAT0027573) and other species homologues or orthologues are included.
  • the hsa-miR-6780b-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6780b-3p” is known as “hsa-mir-6780b” (miRBase Accession No. MI0022681, SEQ ID NO: 689) having a hairpin-like structure as a precursor.
  • hsa-miR-6845-3p gene or “hsa-miR-6845-3p” refers to the hsa-miR-6845-3p gene described in SEQ ID NO: 298 (miRBase Accession No. MIMAT0027591) and other species homologues or orthologues are included.
  • the hsa-miR-6845-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6845-3p “hsa-mir-6845” (miRBase Accession No. MI0022691, SEQ ID NO: 690) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6862-3p gene or “hsa-miR-6862-3p” refers to the hsa-miR-6862-3p gene described in SEQ ID NO: 299 (miRBase Accession No. MIMAT0027626) and other species homologues or orthologues are included.
  • the hsa-miR-6862-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “Hsa-miR-6862-3p” has a hairpin-like structure as a precursor thereof, “hsa-mir-6686-1, hsa-mir-66862-2” (miRBase Accession No. MI0022709, MI0026415, SEQ ID NO: 691, 692).
  • hsa-miR-6865-3p gene or “hsa-miR-6865-3p” refers to the hsa-miR-6865-3p gene described in SEQ ID NO: 300 (miRBase Accession No. MIMAT0027631) and other species homologs or orthologs are included.
  • the hsa-miR-6865-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6865-3p “hsa-mir-6865” (miRBase Accession No. MI0022712, SEQ ID NO: 693) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6870-3p gene or “hsa-miR-6870-3p” refers to the hsa-miR-6870-3p gene described in SEQ ID NO: 301 (miRBase Accession No. MIMAT0027641) and other species homologues or orthologues are included.
  • the hsa-miR-6870-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “Hsa-miR-6870-3p” is known as “hsa-mir-6870” (miRBase Accession No. MI0022717, SEQ ID NO: 694) having a hairpin-like structure as a precursor.
  • hsa-miR-6875-3p gene or “hsa-miR-6875-3p” refers to the hsa-miR-6875-3p gene described in SEQ ID NO: 302 (miRBase Accession No. MIMAT0027651) and other species homologues or orthologues are included.
  • the hsa-miR-6875-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6875-3p” is known as “hsa-mir-6875” (miRBase Accession No. MI0022722, SEQ ID NO: 695) having a hairpin-like structure as a precursor.
  • hsa-miR-6877-3p gene or “hsa-miR-6877-3p” refers to the hsa-miR-6877-3p gene described in SEQ ID NO: 303 (miRBase Accession No. MIMAT0027655) and other species homologues or orthologues are included.
  • the hsa-miR-6877-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6877-3p” is known as “hsa-mir-6877” (miRBase Accession No. MI0022724, SEQ ID NO: 696) having a hairpin-like structure as a precursor.
  • hsa-miR-6879-3p gene or “hsa-miR-6879-3p” refers to the hsa-miR-6879-3p gene described in SEQ ID NO: 304 (miRBase Accession No. MIMAT0027659) and other species homologues or orthologues are included.
  • the hsa-miR-6879-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6879-3p “hsa-mir-6879” (miRBase Accession No. MI0022726, SEQ ID NO: 697) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6882-3p gene or “hsa-miR-6882-3p” refers to the hsa-miR-6882-3p gene described in SEQ ID NO: 305 (miRBase Accession No. MIMAT0027665) and other species homologs or orthologs.
  • the hsa-miR-6882-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “Hsa-miR-6882-3p” is known as “hsa-mir-6882” (miRBase Accession No. MI0022729, SEQ ID NO: 698) having a hairpin-like structure as a precursor.
  • hsa-miR-685-3p gene or “hsa-miR-685-3p” refers to the hsa-miR-685-3p gene described in SEQ ID NO: 306 (miRBase Accession No. MIMAT0027671) and other species homologues or orthologues are included.
  • the hsa-miR-685-3p gene was obtained from Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6885-3p “hsa-mir-6885” (miRBase Accession No. MI0022732, SEQ ID NO: 699) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6886-3p gene or “hsa-miR-6886-3p” refers to the hsa-miR-6886-3p gene described in SEQ ID NO: 307 (miRBase Accession No. MIMAT0027673) and other species homologues or orthologues are included.
  • the hsa-miR-6886-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6886-3p “hsa-mir-6886” (miRBase Accession No. MI0022733, SEQ ID NO: 700) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6887-3p gene or “hsa-miR-6887-3p” refers to the hsa-miR-6887-3p gene described in SEQ ID NO: 308 (miRBase Accession No. MIMAT0027675) and other species homologs or orthologs.
  • the hsa-miR-6877-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6887-3p” is known as “hsa-mir-6877” (miRBase Accession No. MI0022734, SEQ ID NO: 701) having a hairpin-like structure as a precursor.
  • hsa-miR-6890-3p gene or “hsa-miR-6890-3p” refers to the hsa-miR-6890-3p gene described in SEQ ID NO: 309 (miRBase Accession No. MIMAT0027681) and other species homologues or orthologues are included.
  • the hsa-miR-6890-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6890-3p” is known as “hsa-mir-6890” (miRBase Accession No. MI0022737, SEQ ID NO: 702) having a hairpin-like structure as a precursor.
  • hsa-miR-6893-3p gene or “hsa-miR-6893-3p” refers to the hsa-miR-6893-3p gene described in SEQ ID NO: 310 (miRBase Accession No. MIMAT0027687) and other species homologues or orthologues are included.
  • the hsa-miR-6893-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6893-3p” is known as “hsa-mir-6893” (miRBase Accession No. MI0022740, SEQ ID NO: 703) having a hairpin-like structure as a precursor.
  • hsa-miR-6894-3p gene or “hsa-miR-6894-3p” refers to the hsa-miR-6894-3p gene (miRBase Accession No. 3) described in SEQ ID NO: 311. MIMAT0027689) and other species homologs or orthologs.
  • the hsa-miR-6894-3p gene was found in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6894-3p” is known as “hsa-mir-6894” (miRBase Accession No. MI0022741, SEQ ID NO: 704) having a hairpin-like structure as a precursor.
  • hsa-miR-7106-3p gene or “hsa-miR-7106-3p” refers to the hsa-miR-7106-3p gene (miRBase Accession No. 3) described in SEQ ID NO: 312. MIMAT0028110) and other species homologues or orthologues are included.
  • the hsa-miR-7106-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-7106-3p” is known as “hsa-mir-7106” (miRBase Accession No. MI0022957, SEQ ID NO: 705) having a hairpin-like structure as a precursor.
  • hsa-miR-7109-3p gene or “hsa-miR-7109-3p” refers to the hsa-miR-7109-3p gene described in SEQ ID NO: 313 (miRBase Accession No. MIMAT0028116) and other species homologs or orthologs.
  • the hsa-miR-7109-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-mir-7109 (miRBase Accession No. MI0022960, SEQ ID NO: 706) having a hairpin-like structure as a precursor is known.
  • hsa-miR-7114-3p gene or “hsa-miR-7114-3p” refers to the hsa-miR-7114-3p gene described in SEQ ID NO: 314 (miRBase Accession No. MIMAT0028126) and other species homologues or orthologues are included.
  • the hsa-miR-7114-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-7114-3p” is known as “hsa-mir-7114” (miRBase Accession No. MI0022965, SEQ ID NO: 707), which has a hairpin-like structure as a precursor.
  • hsa-miR-7155-5p gene or “hsa-miR-7155-5p” refers to the hsa-miR-7155-5p gene described in SEQ ID NO: 315 (miRBase Accession No. MIMAT0028220) and other species homologs or orthologs.
  • the hsa-miR-7155-5p gene is described in Meunier J et al., 2013, Genome Res. 23, 34-45.
  • hsa-miR-7155-5p “hsa-mir-7155” (miRBase Accession No. MI0023615, SEQ ID NO: 708) having a hairpin-like structure as a precursor is known.
  • hsa-miR-7160-5p gene or “hsa-miR-7160-5p” refers to the hsa-miR-7160-5p gene described in SEQ ID NO: 316 (miRBase Accession No. MIMAT0028230) and other species homologs or orthologs.
  • the hsa-miR-7160-5p gene is described in Meunier J et al., 2013, Genome Res. 23, 34-45.
  • “hsa-miR-7160-5p” is known as “hsa-mir-7160” (miRBase Accession No. MI0023621, SEQ ID NO: 709) having a hairpin-like structure as a precursor.
  • hsa-miR-615-3p gene or “hsa-miR-615-3p” refers to the hsa-miR-615-3p gene described in SEQ ID NO: 317 (miRBase Accession No. MIMAT0003283) and other species homologues or orthologues are included.
  • the hsa-miR-615-3p gene was found in Cummins JM et al., 2006, Proc Natl Acad Sci USA. 103, 3687-3692.
  • “hsa-miR-615-3p” is known as “hsa-mir-615” (miRBase Accession No. MI0003628, SEQ ID NO: 710) having a hairpin-like structure as a precursor.
  • hsa-miR-920 gene or “hsa-miR-920” refers to the hsa-miR-920 gene (miRBase Accession No. MIMAT0004970) described in SEQ ID NO: 318 or other biological species. Homologs or orthologs are included. The hsa-miR-920 gene was found in Novotny GW et al., 2007, Int J Androl. , 30, 316-326. Also, “hsa-miR-920” is known as “hsa-mir-920” (miRBase Accession No. MI0005712, SEQ ID NO: 711) having a hairpin-like structure as a precursor.
  • hsa-miR-1825 gene or “hsa-miR-1825” refers to the hsa-miR-1825 gene (miRBase Accession No. MIMAT0006765) described in SEQ ID NO: 319 or other biological species. Homologs or orthologs are included. The hsa-miR-1825 gene was found in Friedlander MR et al., 2008, Nat Biotechnol. 26, 407-415. As for “hsa-miR-1825”, “hsa-mir-1825” (miRBase Accession No. MI0008193, SEQ ID NO: 712) having a hairpin-like structure as a precursor is known.
  • hsa-miR-675-3p gene or “hsa-miR-675-3p” refers to the hsa-miR-675-3p gene described in SEQ ID NO: 320 (miRBase Accession No. MIMAT0006790) and other species homologues or orthologues are included.
  • the hsa-miR-675-3p gene is disclosed in Cai X et al., 2007, RNA. , Vol. 13, 313-316.
  • hsa-mir-675 (miRBase Accession No. MI0005416, SEQ ID NO: 713) having a hairpin-like structure as a precursor is known.
  • hsa-miR-1910-5p gene or “hsa-miR-1910-5p” refers to the hsa-miR-1910-5p gene described in SEQ ID NO: 321 (miRBase Accession No. MIMAT0007884) and other species homologues or orthologues are included.
  • the hsa-miR-1910-5p gene is described in Bar M et al., 2008, Stem Cells. 26, 2496-2505.
  • “hsa-miR-1910-5p” is known as “hsa-mir-1910” (miRBase Accession No. MI0008331, SEQ ID NO: 714) having a hairpin-like structure as a precursor.
  • hsa-miR-2278 gene or “hsa-miR-2278” refers to the hsa-miR-2278 gene (miRBase Accession No. MIMAT0011778) described in SEQ ID NO: 322 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-2278 gene was obtained from Nygaard S et al., 2009, BMC Med Genomics. 2 and 35.
  • hsa-miR-2278 “hsa-mir-2278” (miRBase Accession No. MI0011285, SEQ ID NO: 715) having a hairpin-like structure as a precursor is known.
  • hsa-miR-2682-3p gene or “hsa-miR-2682-3p” refers to the hsa-miR-2682-3p gene described in SEQ ID NO: 323 (miRBase Accession No. MIMAT0013518) and other species homologs or orthologs.
  • the hsa-miR-2682-3p gene was obtained from Creighton CJ et al., 2010, PLoS One. 5, Vol. 5, e9637.
  • hsa-miR-2682-3p “hsa-mir-2682” (miRBase Accession No. MI0012063, SEQ ID NO: 716) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3122 gene or “hsa-miR-3122” refers to the hsa-miR-3122 gene (miRBase Accession No. MIMAT0014984) described in SEQ ID NO: 324 or other species. Homologs or orthologs are included.
  • the hsa-miR-3122 gene was obtained from Stark MS et al., 2010, PLoS One. No. 5, vol. E9685.
  • hsa-miR-3122 “hsa-mir-3122” (miRBase Accession No. MI0014138, SEQ ID NO: 717) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3151-5p gene or “hsa-miR-3151-5p” refers to the hsa-miR-3151-5p gene described in SEQ ID NO: 325 (miRBase Accession No. MIMAT0015024) and other species homologues or orthologues are included.
  • the hsa-miR-3151-5p gene was obtained from Stark MS et al., 2010, PLoS One. No. 5, vol. E9685.
  • “hsa-miR-3151-5p” is known as “hsa-mir-3151” (miRBase Accession No. MI0014178, SEQ ID NO: 661) having a hairpin-like structure as a precursor.
  • hsa-miR-3175 gene or “hsa-miR-3175” refers to the hsa-miR-3175 gene (miRBase Accession No. MIMAT0015052) described in SEQ ID NO: 326 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-3175 gene was obtained from Creighton CJ et al., 2010, PLoS One. 5, Vol. 5, e9637.
  • hsa-miR-3175 is known as “hsa-mir-3175” (miRBase Accession No. MI0014209, SEQ ID NO: 718) having a hairpin-like structure as a precursor.
  • hsa-miR-4323 gene or “hsa-miR-4323” refers to the hsa-miR-4323 gene (miRBase Accession No. MIMAT0016875) described in SEQ ID NO: 327 or other biological species. Homologs or orthologs are included. The hsa-miR-4323 gene was found in Goff LA et al., 2009, PLoS One. 4, Volume 4, e7192. In addition, “hsa-miR-4323” is known as “hsa-mir-4323” (miRBase Accession No. MI0015853, SEQ ID NO: 719) having a hairpin-like structure as a precursor.
  • hsa-miR-4326 gene or “hsa-miR-4326” refers to the hsa-miR-4326 gene (miRBase Accession No. MIMAT0016888) described in SEQ ID NO: 328 or other biological species. Homologs or orthologs are included. The hsa-miR-4326 gene was found in Goff LA et al., 2009, PLoS One. 4, Volume 4, e7192. As for “hsa-miR-4326”, “hsa-mir-4326” (miRBase Accession No. MI0015866, SEQ ID NO: 720) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4284 gene or “hsa-miR-4284” refers to the hsa-miR-4284 gene (miRBase Accession No. MIMAT0016915) described in SEQ ID NO: 329 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-4284 gene was obtained from Goff LA et al., 2009, PLoS One. 4, Volume 4, e7192.
  • hsa-mir-4284 (miRBase Accession No. MI0015893, SEQ ID NO: 721) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3605-3p gene or “hsa-miR-3605-3p” refers to the hsa-miR-3605-3p gene described in SEQ ID NO: 330 (miRBase Accession No. MIMAT0017982) and other species homologues or orthologues are included.
  • the hsa-miR-3605-3p gene was obtained from Creighton CJ et al., 2010, PLoS One. 5, Vol. 5, e9637.
  • hsa-miR-3605-3p “hsa-mir-3605” (miRBase Accession No. MI0015995, SEQ ID NO: 722) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3622b-5p gene or “hsa-miR-3622b-5p” refers to the hsa-miR-3622b-5p gene described in SEQ ID NO: 331 (miRBase Accession No. 1). MIMAT0018005) and other species homologs or orthologs.
  • the hsa-miR-3622b-5p gene was obtained from Witten D et al., 2010, BMC Biol. , 8, 58.
  • “hsa-miR-3622b-5p” is known as “hsa-mir-3622b” (miRBase Accession No. MI0016014, SEQ ID NO: 723) having a hairpin-like structure as a precursor.
  • hsa-miR-3646 gene or “hsa-miR-3646” refers to the hsa-miR-3646 gene (miRBase Accession No. MIMAT0018065) described in SEQ ID NO: 332 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-3646 gene is described in Meiri E et al., 2010, Nucleic Acids Res. 38, 6234-6246.
  • hsa-miR-3646 is known as “hsa-mir-3646” (miRBase Accession No. MI0016046, SEQ ID NO: 724) having a hairpin-like structure as a precursor.
  • hsa-miR-3158-5p gene or “hsa-miR-3158-5p” refers to the hsa-miR-3158-5p gene (miRBase Accession No. MIMAT0019211) and other species homologues or orthologues are included.
  • the hsa-miR-3158-5p gene was obtained from Creighton CJ et al., 2010, PLoS One. 5, Vol. 5, e9637.
  • “Hsa-miR-3158-5p” has a hairpin-like structure as a precursor thereof, “hsa-mir-3158-1, hsa-mir-3158-2” (miRBase Accession No. MI0014186, MI0014187, SEQ ID NO: 725,726) is known.
  • hsa-miR-4722-3p gene or “hsa-miR-4722-3p” refers to the hsa-miR-4722-3p gene described in SEQ ID NO: 334 (miRBase Accession No. MIMAT0019837) and other species homologs or orthologs.
  • the hsa-miR-4722-3p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4722-3p “hsa-mir-4722” (miRBase Accession No. MI0017357, SEQ ID NO: 727) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4728-3p gene or “hsa-miR-4728-3p” refers to the hsa-miR-4728-3p gene described in SEQ ID NO: 335 (miRBase Accession No. MIMAT0019850) and other species homologs or orthologs.
  • the hsa-miR-4728-3p gene is described in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • “hsa-miR-4728-3p” is known as “hsa-mir-4728” (miRBase Accession No. MI0017365, SEQ ID NO: 393) having a hairpin-like structure as a precursor.
  • hsa-miR-4747-3p gene or “hsa-miR-4747-3p” refers to the hsa-miR-4747-3p gene described in SEQ ID NO: 336 (miRBase Accession No. MIMAT0019883) and other species homologs or orthologs.
  • the hsa-miR-4747-3p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • hsa-miR-4747-3p “hsa-mir-4747” (miRBase Accession No. MI0017386, SEQ ID NO: 728) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4436b-5p gene or “hsa-miR-4436b-5p” refers to the hsa-miR-4436b-5p gene described in SEQ ID NO: 337 (miRBase Accession No. MIMAT0019940) and other species homologs or orthologs.
  • the hsa-miR-4436b-5p gene is disclosed in Persson H et al., 2011, Cancer Res. 71, 78-86.
  • “Hsa-miR-4436b-5p” has a hairpin-like structure as its precursor, “hsa-mir-4436b-1, hsa-mir-4436b-2” (miRBase Accession No. MI0017425, MI0019110, SEQ ID NO: 729, 730).
  • hsa-miR-5196-3p gene or “hsa-miR-5196-3p” refers to the hsa-miR-5196-3p gene described in SEQ ID NO: 338 (miRBase Accession No. MIMAT0021129) and other species homologues or orthologues are included.
  • the hsa-miR-5196-3p gene was obtained from Schotte D et al., 2011, Leukemia. 25, 1389-1399.
  • hsa-miR-5196-3p “hsa-mir-5196” (miRBase Accession No. MI0018175, SEQ ID NO: 731) having a hairpin-like structure as a precursor is known.
  • hsa-miR-5589-5p gene or “hsa-miR-5589-5p” refers to the hsa-miR-5589-5p gene described in SEQ ID NO: 339 (miRBase Accession No. MIMAT0022297) and other species homologs or orthologs.
  • the hsa-miR-5589-5p gene was found in Friedlander MR et al., 2012, Nucleic Acids Res. 40, 37-52.
  • “hsa-miR-5589-5p” is known as “hsa-mir-5589” (miRBase Accession No. MI0019148, SEQ ID NO: 732) having a hairpin-like structure as a precursor.
  • hsa-miR-345-3p gene or “hsa-miR-345-3p” refers to the hsa-miR-345-3p gene described in SEQ ID NO: 340 (miRBase Accession No. MIMAT0022698) and other species homologs or orthologs.
  • the hsa-miR-345-3p gene was found in Kim J et al., 2004, Proc Natl Acad Sci USA. 101, 360-365.
  • “hsa-miR-345-3p” is known as “hsa-mir-345” (miRBase Accession No. MI000025, SEQ ID NO: 615) having a hairpin-like structure as a precursor.
  • hsa-miR-642b-5p gene or “hsa-miR-642b-5p” refers to the hsa-miR-642b-5p gene described in SEQ ID NO: 341 (miRBase Accession No. MIMAT0022736) and other species homologues or orthologues are included.
  • the hsa-miR-642b-5p gene was obtained from Witten D et al., 2010, BMC Biol. , 8, 58.
  • “hsa-miR-642b-5p” is known as “hsa-mir-642b” (miRBase Accession No. MI0016685, SEQ ID NO: 733) having a hairpin-like structure as a precursor.
  • hsa-miR-6716-3p gene or “hsa-miR-6716-3p” refers to the hsa-miR-6716-3p gene described in SEQ ID NO: 342 (miRBase Accession No. MIMAT0025845) and other species homologues or orthologues are included.
  • the hsa-miR-6716-3p gene is described in Li Y et al., 2012, Gene. 497, 330-335.
  • hsa-miR-6716-3p “hsa-mir-6716” (miRBase Accession No. MI0022550, SEQ ID NO: 734) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6511b-3p gene or “hsa-miR-6511b-3p” refers to the hsa-miR-6511b-3p gene described in SEQ ID NO: 343 (miRBase Accession No. MIMAT0025848) and other species homologs or orthologs.
  • the hsa-miR-6511b-3p gene is disclosed in Li Y et al., 2012, Gene. 497, 330-335.
  • “Hsa-miR-6511b-3p” has a hairpin-like structure as its precursor, “hsa-mir-6651b-1, hsa-mir-6511b-2” (miRBase Accession No. MI0022552, MI0023431, SEQ ID NO: 735, 736).
  • hsa-miR-208a-5p gene or “hsa-miR-208a-5p” refers to the hsa-miR-208a-5p gene described in SEQ ID NO: 344 (miRBase Accession No. MIMAT0026474) and other species homologues or orthologues are included.
  • the hsa-miR-208a-5p gene was obtained from Lagos-Quintana M et al., 2003, RNA. 9, 175-179.
  • “hsa-miR-208a-5p” “hsa-mir-208a” (miRBase Accession No. MI000000251, SEQ ID NO: 737) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6726-3p gene or “hsa-miR-6726-3p” refers to the hsa-miR-6726-3p gene described in SEQ ID NO: 345 (miRBase Accession No. MIMAT0027354) and other species homologs or orthologs.
  • the hsa-miR-6726-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6726-3p “hsa-mir-6726” (miRBase Accession No. MI0022571, SEQ ID NO: 600) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6744-5p gene or “hsa-miR-6744-5p” refers to the hsa-miR-6744-5p gene described in SEQ ID NO: 346 (miRBase Accession No. MIMAT0027389) and other species homologues or orthologues are included.
  • the hsa-miR-6744-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6744-5p “hsa-mir-6744” (miRBase Accession No. MI0022589, SEQ ID NO: 738) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6787-3p gene or “hsa-miR-6787-3p” refers to the hsa-miR-6682-3p gene (miRBase Accession No. MIMAT0027465) and other species homologues or orthologues are included.
  • the hsa-miR-6882-3p gene was obtained from Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6882-3p” is known as “hsa-mir-6782” (miRBase Accession No. MI0022627, SEQ ID NO: 739) having a hairpin-like structure as a precursor.
  • hsa-miR-6789-3p gene or “hsa-miR-6789-3p” refers to the hsa-miR-6789-3p gene described in SEQ ID NO: 348 (miRBase Accession No. MIMAT0027479) and other species homologs or orthologs.
  • the hsa-miR-6789-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6789-3p” is known as “hsa-mir-6789” (miRBase Accession No. MI0022634, SEQ ID NO: 740) having a hairpin-like structure as a precursor.
  • hsa-miR-6797-3p gene or “hsa-miR-6797-3p” refers to the hsa-miR-6797-3p gene described in SEQ ID NO: 349 (miRBase Accession No. MIMAT0027495) and other species homologs or orthologs.
  • the hsa-miR-6797-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6797-3p” is known as “hsa-mir-6797” (miRBase Accession No. MI0022642, SEQ ID NO: 741) having a hairpin-like structure as a precursor.
  • hsa-miR-6800-3p gene or “hsa-miR-6800-3p” refers to the hsa-miR-6800-3p gene described in SEQ ID NO: 350 (miRBase Accession No. MIMAT0027501) and other species homologues or orthologues are included.
  • the hsa-miR-6800-3p gene was found in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6800-3p” is known as “hsa-mir-6800” (miRBase Accession No. MI0022645, SEQ ID NO: 491) having a hairpin-like structure as a precursor.
  • hsa-miR-6806-5p gene or “hsa-miR-6806-5p” refers to the hsa-miR-6806-5p gene described in SEQ ID NO: 351 (miRBase Accession No. 5). MIMAT0027512) and other species homologues or orthologues are included.
  • the hsa-miR-6806-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6806-5p” is known as “hsa-mir-6806” (miRBase Accession No. MI0022651, SEQ ID NO: 742) having a hairpin-like structure as a precursor.
  • hsa-miR-6824-3p gene or “hsa-miR-6824-3p” refers to the hsa-miR-6824-3p gene described in SEQ ID NO: 352 (miRBase Accession No. MIMAT0027549) and other species homologues or orthologues are included.
  • the hsa-miR-6824-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6824-3p “hsa-mir-6824” (miRBase Accession No. MI0022669, SEQ ID NO: 743) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6837-5p gene or “hsa-miR-6837-5p” refers to the hsa-miR-6837-5p gene described in SEQ ID NO: 353 (miRBase Accession No. MIMAT0027576) and other species homologs or orthologs.
  • the hsa-miR-6837-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6837-5p “hsa-mir-6683” (miRBase Accession No. MI0022683, SEQ ID NO: 744) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6864-3p gene or “hsa-miR-6846-3p” refers to the hsa-miR-6846-3p gene (miRBase Accession No. 5) described in SEQ ID NO: 354. MIMAT0027593) and other species homologs or orthologs.
  • the hsa-miR-6864-3p gene was obtained from Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6846-3p” is known as “hsa-mir-6846” (miRBase Accession No. MI0022692, SEQ ID NO: 745) having a hairpin-like structure as a precursor.
  • hsa-miR-6858-3p gene or “hsa-miR-6858-3p” refers to the hsa-miR-6858-3p gene described in SEQ ID NO: 355 (miRBase Accession No. MIMAT0027617) and other species homologues or orthologues are included.
  • the hsa-miR-6858-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6858-3p” is known as “hsa-mir-6858” (miRBase Accession No. MI0022704, SEQ ID NO: 746) having a hairpin-like structure as a precursor.
  • hsa-miR-6859-3p gene or “hsa-miR-6859-3p” refers to the hsa-miR-6859-3p gene described in SEQ ID NO: 356 (miRBase Accession No. MIMAT0027619) and other species homologues or orthologues are included.
  • the hsa-miR-6859-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “Hsa-miR-6858-3p” has a hairpin-like structure as its precursor, “hsa-mir-6859-1, hsa-mir-6856-2, hsa-mir-6659-3, hsa-mir”.
  • -6859-4 "(miRBBase Accession No. MI0022705, MI0026420, MI0026421, MI0031521, SEQ ID NOs: 747, 748, 749, 750) are known.
  • hsa-miR-6861-3p gene or “hsa-miR-6861-3p” refers to the hsa-miR-6861-3p gene described in SEQ ID NO: 357 (miRBase Accession No. MIMAT0027624) and other species homologs or orthologs.
  • the hsa-miR-6861-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6861-3p “hsa-mir-6861” (miRBase Accession No. MI0022708, SEQ ID NO: 596) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6880-3p gene or “hsa-miR-6880-3p” refers to the hsa-miR-6880-3p gene described in SEQ ID NO: 358 (miRBase Accession No. MIMAT0027661) and other species homologues or orthologues are included.
  • the hsa-miR-6880-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6880-3p “hsa-mir-6880” (miRBase Accession No. MI0022727, SEQ ID NO: 751) having a hairpin-like structure as a precursor is known.
  • hsa-miR-7111-3p gene or “hsa-miR-7111-3p” refers to the hsa-miR-7111-3p gene described in SEQ ID NO: 359 (miRBase Accession No. MIMAT0028120) and other species homologs or orthologs.
  • the hsa-miR-7111-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-7111-3p “hsa-mir-7111” (miRBase Accession No. MI0022962, SEQ ID NO: 752) having a hairpin-like structure as a precursor is known.
  • hsa-miR-7152-5p gene or “hsa-miR-7152-5p” refers to the hsa-miR-7152-5p gene described in SEQ ID NO: 360 (miRBase Accession No. MIMAT0028214) and other species homologues or orthologues are included.
  • the hsa-miR-7152-5p gene is described in Meunier J et al., 2013, Genome Res. 23, 34-45.
  • “hsa-miR-7152-5p” is known as “hsa-mir-7152” (miRBase Accession No. MI0023612, SEQ ID NO: 753) having a hairpin-like structure as a precursor.
  • hsa-miR-642a-5p gene or “hsa-miR-642a-5p” refers to the hsa-miR-642a-5p gene described in SEQ ID NO: 361 (miRBase Accession No. MIMAT0003312) and other species homologs or orthologs.
  • the hsa-miR-642a-5p gene was found in Cummins JM et al., 2006, Proc Natl Acad Sci US A. 103, 3687-3692.
  • “hsa-miR-642a-5p” is known as “hsa-mir-642a” (miRBase Accession No. MI0003657, SEQ ID NO: 754) having a hairpin-like structure as a precursor.
  • hsa-miR-657 gene or “hsa-miR-657” refers to the hsa-miR-657 gene (miRBase Accession No. MIMAT0003335) described in SEQ ID NO: 362 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-657 gene was obtained from Cummins JM et al., 2006, Proc Natl Acad Sci USA. 103, 3687-3692.
  • hsa-miR-657 “hsa-mir-657” (miRBase Accession No. MI0003681, SEQ ID NO: 755) having a hairpin-like structure as a precursor is known.
  • hsa-miR-1236-3p gene or “hsa-miR-1236-3p” refers to the hsa-miR-1236-3p gene described in SEQ ID NO: 363 (miRBase Accession No. MIMAT0005591) and other species homologues or orthologues are included.
  • the hsa-miR-1236-3p gene was obtained from Berezikov E et al., 2007, Mol Cell. 28, 328-336.
  • “hsa-miR-1236-3p” is known as “hsa-mir-1236” (miRBase Accession No. MI0006326, SEQ ID NO: 756) having a hairpin-like structure as a precursor.
  • hsa-miR-764 gene or “hsa-miR-764” refers to the hsa-miR-764 gene (miRBase Accession No. MIMAT0010367) described in SEQ ID NO: 364 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-764 gene was obtained from Berezkov E et al., 2006, Genome Res. 16, Vol. 1629-1298.
  • hsa-miR-764 “hsa-mir-764” (miRBase Accession No. MI0003944, SEQ ID NO: 757) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4314 gene or “hsa-miR-4314” refers to the hsa-miR-4314 gene (miRBase Accession No. MIMAT0016868) described in SEQ ID NO: 365 and other biological species. Homologs or orthologs are included. The hsa-miR-4314 gene was found in Goff LA et al., 2009, PLoS One. 4, Volume 4, e7192. As for “hsa-miR-4314”, “hsa-mir-4314” (miRBase Accession No. MI0015846, SEQ ID NO: 758) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3675-3p gene or “hsa-miR-3675-3p” refers to the hsa-miR-3675-3p gene described in SEQ ID NO: 366 (miRBase Accession No. MIMAT0018099) and other species homologs or orthologs.
  • the hsa-miR-3675-3p gene was obtained from Vaz C et al., 2010, BMC Genomics. 11 and 288.
  • “hsa-miR-3675-3p” is known as “hsa-mir-3675” (miRBase Accession No. MI0016076, SEQ ID NO: 759) having a hairpin-like structure as a precursor.
  • hsa-miR-5703 gene or “hsa-miR-5703” refers to the hsa-miR-5703 gene (miRBase Accession No. MIMAT0022496) described in SEQ ID NO: 367 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-5703 gene was obtained from Watahiki A et al., 2011, PLoS One. 6, Volume 24, e24950.
  • hsa-miR-5703 “hsa-mir-5703” (miRBase Accession No. MI0019310, SEQ ID NO: 760) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3191-5p gene or “hsa-miR-3191-5p” refers to the hsa-miR-3191-5p gene described in SEQ ID NO: 368 (miRBase Accession No. MIMAT0022732) and other species homologues or orthologues are included.
  • the hsa-miR-3191-5p gene was obtained from Stark MS et al., 2010, PLoS One. No. 5, vol. E9685.
  • “hsa-miR-3191-5p” is known as “hsa-mir-3191” (miRBase Accession No. MI0014236, SEQ ID NO: 761) having a hairpin-like structure as a precursor.
  • hsa-miR-6511a-3p gene or “hsa-miR-6511a-3p” refers to the hsa-miR-6511a-3p gene described in SEQ ID NO: 369 (miRBase Accession No. MIMAT0025479) and other species homologs or orthologs.
  • the hsa-miR-6511a-3p gene was obtained from Joyce CE et al., 2011, Hum Mol Genet. 20, Vol. 4025-4040.
  • “hsa-miR-6511a-3p” is known as “hsa-mir-6511a-1” (miRBase Accession No. MI0022223, SEQ ID NO: 445) having a hairpin-like structure as a precursor.
  • hsa-miR-6809-3p gene or “hsa-miR-6809-3p” refers to the hsa-miR-6809-3p gene described in SEQ ID NO: 370 (miRBase Accession No. MIMAT0027519) and other species homologues or orthologues are included.
  • the hsa-miR-6809-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6809-3p” is known as “hsa-mir-6809” (miRBase Accession No. MI0022654, SEQ ID NO: 762) having a hairpin-like structure as a precursor.
  • hsa-miR-6815-5p gene or “hsa-miR-6815-5p” refers to the hsa-miR-6815-5p gene described in SEQ ID NO: 371 (miRBase Accession No. MIMAT0027530) and other species homologues or orthologues are included.
  • the hsa-miR-6815-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6815-5p” is known as “hsa-mir-6815” (miRBase Accession No. MI0022660, SEQ ID NO: 763) having a hairpin-like structure as a precursor.
  • hsa-miR-6857-3p gene or “hsa-miR-6857-3p” refers to the hsa-miR-6857-3p gene described in SEQ ID NO: 372 (miRBase Accession No. MIMAT0027615) and other species homologs or orthologs.
  • the hsa-miR-6857-3p gene is disclosed in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • hsa-miR-6857-3p “hsa-mir-6857” (miRBase Accession No. MI0022703, SEQ ID NO: 764) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6878-3p gene or “hsa-miR-6878-3p” refers to the hsa-miR-6878-3p gene described in SEQ ID NO: 373 (miRBase Accession No. MIMAT0027657) and other species homologs or orthologs.
  • the hsa-miR-6878-3p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6878-3p” is known as “hsa-mir-6878” (miRBase Accession No. MI0022725, SEQ ID NO: 765) having a hairpin-like structure as a precursor.
  • hsa-miR-371a-5p gene or “hsa-miR-371a-5p” refer to the hsa-miR-371a-5p gene described in SEQ ID NO: 374 (miRBase Accession No. MIMAT0004687) and other species homologues or orthologues are included.
  • the hsa-miR-371a-5p gene is described in Suh MR et al., 2004, Dev Biol. 270, 488-498.
  • hsa-miR-371a-5p “hsa-mir-371a” (miRBase Accession No. MI000079, SEQ ID NO: 766) having a hairpin-like structure as a precursor is known.
  • hsa-miR-766-3p gene or “hsa-miR-766-3p” refers to the hsa-miR-766-3p gene described in SEQ ID NO: 375 (miRBase Accession No. MIMAT0003888) and other species homologues or orthologues are included.
  • the hsa-miR-766-3p gene was obtained from Berezikov E et al., 2006, Genome Res. 16, Vol. 1629-1298.
  • hsa-miR-766-3p “hsa-mir-766” (miRBase Accession No. MI0003836, SEQ ID NO: 767) having a hairpin-like structure as a precursor is known.
  • hsa-miR-1229-3p gene or “hsa-miR-1229-3p” refers to the hsa-miR-1229-3p gene described in SEQ ID NO: 376 (miRBase Accession No. MIMAT0005584) and other species homologs or orthologs.
  • the hsa-miR-1229-3p gene was obtained from Berezikov E et al., 2007, Mol Cell. 28, 328-336.
  • “hsa-miR-1229-3p” is known as “hsa-mir-1229” (miRBase Accession No. MI0006319, SEQ ID NO: 768) having a hairpin-like structure as a precursor.
  • hsa-miR-1306-5p gene or “hsa-miR-1306-5p” refers to the hsa-miR-1306-5p gene described in SEQ ID NO: 377 (miRBase Accession No. MIMAT0022726) and other species homologs or orthologs.
  • the hsa-miR-1306-5p gene is described in Morin RD et al., 2008, Genome Res. 18, 610-621.
  • hsa-miR-1306-5p “hsa-mir-1306” (miRBase Accession No. MI0006443, SEQ ID NO: 769) having a hairpin-like structure as a precursor is known.
  • hsa-miR-210-5p gene or “hsa-miR-210-5p” refers to the hsa-miR-210-5p gene described in SEQ ID NO: 378 (miRBase Accession No. MIMAT0026475) and other species homologs or orthologs.
  • the hsa-miR-210-5p gene is described in Lim LP et al., 2003, Science. 299, 1540.
  • hsa-mir-210 miRBase Accession No. MI00000028, SEQ ID NO: 770 having a hairpin-like structure as a precursor is known.
  • hsa-miR-198 gene or “hsa-miR-198” refers to the hsa-miR-198 gene (miRBase Accession No. MIMAT000028) described in SEQ ID NO: 379 or other species. Homologs or orthologs are included.
  • the hsa-miR-198 gene was obtained from Lagos-Quintana M et al., 2003, RNA. 9, 175-179.
  • hsa-miR-198 “hsa-mir-198” (miRBase Accession No. MI0000240, SEQ ID NO: 771) having a hairpin-like structure as a precursor is known.
  • hsa-miR-485-3p gene or “hsa-miR-485-3p” refers to the hsa-miR-485-3p gene described in SEQ ID NO: 380 (miRBase Accession No. MIMAT0002176) and other species homologues or orthologues are included.
  • the hsa-miR-485-3p gene was obtained from Bentwich I et al., 2005, Nat Genet. 37, 766-770.
  • “hsa-miR-485-3p” is known as “hsa-mir-485” (miRBase Accession No. MI0002469, SEQ ID NO: 772) having a hairpin-like structure as a precursor.
  • hsa-miR-668-3p gene or “hsa-miR-668-3p” refers to the hsa-miR-668-3p gene described in SEQ ID NO: 381 (miRBase Accession No. MIMAT0003881) and other species homologues or orthologues are included.
  • the hsa-miR-668-3p gene was obtained from Berezikov E et al., 2006, Genome Res. 16, Vol. 1629-1298.
  • hsa-miR-668-3p “hsa-mir-668” (miRBase Accession No. MI0003761, SEQ ID NO: 773) having a hairpin-like structure as a precursor is known.
  • hsa-miR-532-3p gene or “hsa-miR-532-3p” refers to the hsa-miR-532-3p gene described in SEQ ID NO: 382 (miRBase Accession No. MIMAT0004780) and other species homologs or orthologs.
  • the hsa-miR-532-3p gene is described in Lagos-Quintana M et al., 2001, Science. 294, 853-858.
  • “hsa-miR-532-3p” is known as “hsa-mir-532” (miRBase Accession No. MI0003205, SEQ ID NO: 626) having a hairpin-like structure as a precursor.
  • hsa-miR-877-3p gene or “hsa-miR-877-3p” refers to the hsa-miR-877-3p gene described in SEQ ID NO: 383 (miRBase Accession No. MIMAT0004950) and other species homologs or orthologs.
  • the hsa-miR-877-3p gene was obtained from Berezikov E et al., 2006, Genome Res. 16, Vol. 1629-1298.
  • hsa-miR-877-3p is known as “hsa-mir-877” (miRBase Accession No. MI0005561, SEQ ID NO: 774) having a hairpin-like structure as a precursor.
  • hsa-miR-1238-3p gene or “hsa-miR-1238-3p” refers to the hsa-miR-1238-3p gene described in SEQ ID NO: 384 (miRBase Accession No. MIMAT0005593) and other species homologues or orthologues are included.
  • the hsa-miR-1238-3p gene was obtained from Berezikov E et al., 2007, Mol Cell. 28, 328-336.
  • “hsa-miR-1238-3p” is known as “hsa-mir-1238” (miRBase Accession No. MI0006328, SEQ ID NO: 775) having a hairpin-like structure as a precursor.
  • hsa-miR-3130-5p gene or “hsa-miR-3130-5p” refers to the hsa-miR-3130-5p gene described in SEQ ID NO: 385 (miRBase Accession No. MIMAT0014995) and other species homologs or orthologs.
  • the hsa-miR-3130-5p gene was obtained from Creighton CJ et al., 2010, PLoS One. 5, Vol. 5, e9637.
  • “Hsa-miR-3130-5p” has a hairpin-like structure as its precursor, “hsa-mir-3130-1, hsa-mir-3130-2” (miRBase Accession No. MI0014147, MI0014148, SEQ ID NO: 776,777) are known.
  • hsa-miR-4298 gene or “hsa-miR-4298” refers to the hsa-miR-4298 gene (miRBase Accession No. MIMAT0016852) described in SEQ ID NO: 386 or other biological species. Homologs or orthologs are included. The hsa-miR-4298 gene was found in Goff LA et al., 2009, PLoS One. 4, Volume 4, e7192. Also, “hsa-miR-4298” is known as “hsa-mir-4298” (miRBase Accession No. MI0015830, SEQ ID NO: 778) having a hairpin-like structure as a precursor.
  • hsa-miR-4290 gene or “hsa-miR-4290” refers to the hsa-miR-4290 gene (miRBase Accession No. MIMAT0016921) described in SEQ ID NO: 387 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-4290 gene was obtained from Goff LA et al., 2009, PLoS One. 4, Volume 4, e7192.
  • “hsa-miR-4290” is known as “hsa-mir-4290” (miRBase Accession No. MI0015899, SEQ ID NO: 779) having a hairpin-like structure as a precursor.
  • hsa-miR-3943 gene or “hsa-miR-3943” refers to the hsa-miR-3943 gene (miRBase Accession No. MIMAT0018359) described in SEQ ID NO: 388 or other biological species. Homologs or orthologs are included. The hsa-miR-3943 gene was found in Liao JY et al., 2010, PLoS One. 5, Vol. 5, e10563. Also, “hsa-miR-3943” is known as “hsa-mir-3943” (miRBase Accession No. MI0016600, SEQ ID NO: 780) having a hairpin-like structure as a precursor.
  • hsa-miR-346 gene or “hsa-miR-346” refers to the hsa-miR-346 gene (miRBase Accession No. MIMAT000003) described in SEQ ID NO: 389 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-346 gene was found in Kim J et al., 2004, Proc Natl Acad Sci US A. 101, 360-365.
  • hsa-mir-346 (miRBase Accession No. MI000026, SEQ ID NO: 781) having a hairpin-like structure as a precursor is known.
  • hsa-miR-767-3p gene or “hsa-miR-767-3p” refers to the hsa-miR-767-3p gene described in SEQ ID NO: 390 (miRBase Accession No. MIMAT0003883) and other species homologs or orthologs are included.
  • the hsa-miR-767-3p gene was obtained from Berezikov E et al., 2006, Genome Res. 16, Vol. 1629-1298.
  • “Hsa-miR-767-3p” is known as “hsa-mir-767” (miRBase Accession No. MI0003763, SEQ ID NO: 782) having a hairpin-like structure as a precursor.
  • hsa-miR-6765-3p gene or “hsa-miR-6765-3p” refers to the hsa-miR-6765-3p gene described in SEQ ID NO: 1315 (miRBaseAccession No. MIMAT0027431) And other species homologs or orthologs.
  • the hsa-miR-6765-3p gene can be obtained by the method described in LadewigE et al., 2012, GenomeRes, 22, p1634-1645.
  • hsa-mir-6765 miRBaseAccession No. MI0022610, SEQ ID NO: 490 having a hairpin-like structure as a precursor is known.
  • hsa-miR-6784-5p gene or “hsa-miR-6784-5p” refer to the hsa-miR-6784-5p gene described in SEQ ID NO: 1316 (miRBaseAccessionNo.MIMAT0027468) And other species homologs or orthologs.
  • the hsa-miR-6784-5p gene can be obtained by the method described in Ladewig E et al., 2012, GenomeRes, 22, p1634-1645.
  • “hsa-miR-6784-5p” “hsa-mir-6784” (miRBaseAccession No. MI0022629, SEQ ID NO: 1357) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6778-5p gene or “hsa-miR-6778-5p” refers to the hsa-miR-6778-5p gene described in SEQ ID NO: 1317 (miRBaseAccessionNo. MIMAT0027456). And other species homologs or orthologs.
  • the hsa-miR-6778-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, p1634-1645.
  • “hsa-miR-6778-5p” is known as “hsa-mir-6778” (miRBaseAccession No. MI0022623, SEQ ID NO: 1358) having a hairpin-like structure as a precursor.
  • hsa-miR-6875-5p gene or “hsa-miR-6875-5p” refers to the hsa-miR-6875-5p gene set forth in SEQ ID NO: 1318 (miRBaseAccessionNo. MIMAT0027650). And other species homologs or orthologs.
  • the hsa-miR-6875-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, Vol. 22, p1634-1645.
  • “hsa-miR-6875-5p” “hsa-mir-6875” (miRBaseAccession No. MI0022722, SEQ ID NO: 1359) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4534 gene or “hsa-miR-4534” refers to the hsa-miR-4534 gene (miRBaseAccession No. MIMAT0019073) described in SEQ ID NO: 1319 or other species homolog Orthologs and the like are included.
  • the hsa-miR-4534 gene can be obtained by the method described in JimDD et al., 2010, Blood, 116, e118-e127.
  • hsa-mir-4534 miRBaseAccession No. MI0016901, SEQ ID NO: 1360 having a hairpin-like structure as a precursor is known.
  • hsa-miR-4721 gene or “hsa-miR-4721” refers to the hsa-miR-4721 gene (miRBaseAccession No. MIMAT0019835) described in SEQ ID NO: 1320 or other species homolog or Orthologs and the like are included.
  • the hsa-miR-4721 gene can be obtained by the method described in PerssonH et al., 2011, Cancer Res, 71, p78-86.
  • “hsa-miR-4721” “hsa-mir-4721” (miRBaseAccession No. MI0017356, SEQ ID NO: 1361), which takes a hairpin-like structure as a precursor, is known.
  • hsa-miR-6756-5p gene or “hsa-miR-6756-5p” refers to the hsa-miR-6756-5p gene described in SEQ ID NO: 1321 (miRBaseAccessionNo.MIMAT0027412). And other species homologs or orthologs.
  • the hsa-miR-6756-5p gene can be obtained by the method described in Ladewig E et al., 2012, GenomeRes, 22, p1634-1645.
  • “hsa-miR-6756-5p” is known as “hsa-mir-6756” (miRBaseAccession No. MI0022601, SEQ ID NO: 1362) having a hairpin-like structure as a precursor.
  • hsa-miR-615-5p gene or “hsa-miR-615-5p” refers to the hsa-miR-615-5p gene described in SEQ ID NO: 1322 (miRBaseAccession No. MIMAT0004804). And other species homologs or orthologs.
  • the hsa-miR-615-5p gene can be obtained by the method described in Cummins JM et al., 2006, ProcNatlAcadSciUSA, 103, p3687-3692.
  • hsa-miR-615-5p “hsa-mir-615” (miRBaseAccession No. MI0003628, SEQ ID NO: 1363) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6727-5p gene or “hsa-miR-6727-5p” refers to the hsa-miR-6727-5p gene described in SEQ ID NO: 1323 (miRBaseAccessionNo.MIMAT0027355). And other species homologs or orthologs.
  • the hsa-miR-6727-5p gene can be obtained by the method described in Ladewig E et al., 2012, GenomeRes, 22, p1634-1645.
  • “hsa-miR-6727-5p” “hsa-mir-6727” (miRBaseAccession No. MI0022572, SEQ ID NO: 1364) having a hairpin-like structure as a precursor is known.
  • hsa-miR-687-5p gene or “hsa-miR-6687-5p” refers to the hsa-miR-6687-5p gene described in SEQ ID NO: 1324 (miRBaseAccessionNo.MIMAT0027674). And other species homologs or orthologs.
  • the hsa-miR-6687-5p gene can be obtained by the method described in Ladewig E et al., 2012, GenomeRes, 22, p1634-1645.
  • “hsa-miR-687-5p” is known as “hsa-mir-6687” (miRBaseAccession No. MI0022734, SEQ ID NO: 1365) having a hairpin-like structure as a precursor.
  • hsa-miR-8063 gene or “hsa-miR-8063” refers to the hsa-miR-8063 gene (miRBaseAccession No. MIMAT0030990) described in SEQ ID NO: 1325 or other species homolog or Orthologs and the like are included.
  • the hsa-miR-8063 gene can be obtained by the method described in WangHJ et al., 2013, Shock, 39, p480-487.
  • hsa-miR-8063 “hsa-mir-8063” (miRBaseAccession No. MI0025899, SEQ ID NO: 1366) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6880-5p gene or “hsa-miR-6880-5p” refers to the hsa-miR-6880-5p gene described in SEQ ID NO: 1326 (miRBaseAccessionNo.MIMAT0027660). And other species homologs or orthologs.
  • the hsa-miR-6880-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, p1634-1645.
  • “hsa-miR-6880-5p” is known as “hsa-mir-6880” (miRBaseAccession No. MI0022727, SEQ ID NO: 1367) having a hairpin-like structure as a precursor.
  • hsa-miR-6805-3p gene or “hsa-miR-6805-3p” refers to the hsa-miR-6805-3p gene described in SEQ ID NO: 1327 (miRBaseAccession No. MIMAT0027511). And other species homologs or orthologs.
  • the hsa-miR-6805-3p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, p1634-1645.
  • “hsa-miR-6805-3p” is known as “hsa-mir-6805” (miRBaseAccession No. MI0022650, SEQ ID NO: 1368) having a hairpin-like structure as a precursor.
  • hsa-miR-4726-5p gene or “hsa-miR-4726-5p” refers to the hsa-miR-4726-5p gene described in SEQ ID NO: 1328 (miRBaseAccession No. MIMAT0019845). And other species homologs or orthologs.
  • the hsa-miR-4726-5p gene can be obtained by the method described in Personson H et al., 2011, Cancer Res, 71, p78-86.
  • “hsa-miR-4726-5p” is known as “hsa-mir-4726” (miRBaseAccession No. MI0017363, SEQ ID NO: 1369) having a hairpin-like structure as a precursor.
  • hsa-miR-4710 gene or “hsa-miR-4710” refers to the hsa-miR-4710 gene (miRBaseAccession No. MIMAT0019815) described in SEQ ID NO: 1329 or other species homolog Orthologs and the like are included.
  • the hsa-miR-4710 gene can be obtained by the method described in PerssonH et al., 2011, Cancer Res, 71, p78-86.
  • “hsa-miR-4710” “hsa-mir-4710” (miRBaseAccession No. MI0017344, SEQ ID NO: 1370), which has a hairpin-like structure as a precursor, is known.
  • hsa-miR-7111-5p gene or “hsa-miR-7111-5p” refers to the hsa-miR-7111-5p gene described in SEQ ID NO: 1330 (miRBaseAccession No. MIMAT0028119). And other species homologs or orthologs.
  • the hsa-miR-7111-5p gene can be obtained by the method described in Ladewig E et al., 2012, Genome Res, 22, p1634-1645.
  • hsa-miR-7111-5p “hsa-mir-7111” (miRBaseAccession No. MI0022962, SEQ ID NO: 1371) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3619-3p gene or “hsa-miR-3619-3p” refers to the hsa-miR-3619-3p gene described in SEQ ID NO: 1331 (miRBaseAccession No. MIMAT0019219). And other species homologs or orthologs.
  • the hsa-miR-3619-3p gene can be obtained by the method described in WittenD et al., 2010, BMC Biol, 8, p58.
  • “hsa-miR-3619-3p” “hsa-mir-3619” (miRBaseAccession No. MI0016009, SEQ ID NO: 1372) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6695-5p gene or “hsa-miR-6695-5p” refers to the hsa-miR-6695-5p gene described in SEQ ID NO: 1332 (miRBaseAccessionNo. MIMAT0027490). And other species homologs or orthologs.
  • the hsa-miR-6695-5p gene can be obtained by the method described in Ladewig E et al., 2012, GenomeRes, 22, p1634-1645.
  • “Hsa-miR-6695-5p” is known as “hsa-mir-6695” (miRBaseAccession No. MI0022640, SEQ ID NO: 1373) having a hairpin-like structure as a precursor.
  • hsa-miR-1254 gene or “hsa-miR-1254” refers to the hsa-miR-1254 gene (miRBaseAccession No. MIMAT0005905) described in SEQ ID NO: 1333 or other species homolog or Orthologs and the like are included.
  • the hsa-miR-1254 gene can be obtained by the method described in MorinRD et al., 2008, GenomeRes, 18, p610-621.
  • “Hsa-miR-1254” has a hairpin-like structure as a precursor thereof, “hsa-mir-1254-1, hsa-mir-1254-2” (miRBaseAccession No. MI0006388, MI0016747, SEQ ID NOs: 1374, 1375). It has been known.
  • hsa-miR-1233-5p gene or “hsa-miR-1233-5p” refers to the hsa-miR-1233-5p gene described in SEQ ID NO: 1334 (miRBaseAccession No. MIMAT0022943). And other species homologs or orthologs.
  • the hsa-miR-1233-5p gene can be obtained by the method described in Berezikov E et al., 2007, Mol Cell, 28, p328-336.
  • “hsa-miR-1233-5p” has “hsa-mir-1233-1, hsa-mir-1233-2” (miRBaseAccession No. MI0006323, MI0015973, SEQ ID NO: 1376, which takes a hairpin-like structure as a precursor thereof. 1377) is known.
  • hsa-miR-6836-3p gene or “hsa-miR-6836-3p” refers to the hsa-miR-6636-3p gene set forth in SEQ ID NO: 1335 (miRBaseAccession No. MIMAT0027575). And other species homologs or orthologs.
  • the hsa-miR-6683-3p gene can be obtained by the method described in Ladewig E et al., 2012, GenomeRes, 22, p1634-1645.
  • hsa-miR-6836-3p “hsa-mir-6836” (miRBaseAccession No. MI0022682, SEQ ID NO: 1378) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6769a-5p gene or “hsa-miR-6769a-5p” refers to the hsa-miR-6769a-5p gene described in SEQ ID NO: 1336 (miRBaseAccession No. MIMAT0027438). And other species homologs or orthologs.
  • the hsa-miR-6769a-5p gene can be obtained by the method described in Ladewig E et al., 2012, GenomeRes, 22, p1634-1645.
  • “hsa-miR-6769a-5p” is known as “hsa-mir-6769a” (miRBaseAccession No. MI0022614, SEQ ID NO: 1379) having a hairpin-like structure as a precursor.
  • hsa-miR-4532 gene or “hsa-miR-4532” refers to the hsa-miR-4532 gene (miRBaseAccession No. MIMAT0019071) described in SEQ ID NO: 1337 or other species homolog Orthologs and the like are included.
  • the hsa-miR-4532 gene can be obtained by the method described in JimDD et al., 2010, Blood, 116, e118-e127.
  • hsa-mir-4532 miRBaseAccession No. MI0016899, SEQ ID NO: 1380 having a hairpin-like structure as a precursor is known.
  • hsa-miR-365a-5p gene or “hsa-miR-365a-5p” refers to the hsa-miR-365a-5p gene described in SEQ ID NO: 1338 (miRBaseAccessionNo. MIMAT0009199). And other species homologs or orthologs.
  • the hsa-miR-365a-5p gene can be obtained by the method described in XieX et al., 2005, Nature, 434, p338-345.
  • hsa-mir-365a miRBaseAccession No. MI000067, SEQ ID NO: 1381 having a hairpin-like structure as a precursor is known.
  • hsa-miR-1231 gene or “hsa-miR-1231” refers to the hsa-miR-1231 gene (miRBaseAccession No. MIMAT0005586) described in SEQ ID NO: 1339 or other species homolog Orthologs and the like are included.
  • the hsa-miR-1231 gene can be obtained by the method described in Berezkov E et al., 2007, MolCell, 28, p328-336.
  • “hsa-miR-1231” is known as “hsa-mir-1231” (miRBaseAccession No. MI0006321, SEQ ID NO: 1382) having a hairpin-like structure as a precursor.
  • hsa-miR-1228-5p gene or “hsa-miR-1228-5p” refers to the hsa-miR-1228-5p gene described in SEQ ID NO: 1340 (miRBaseAccession No. MIMAT0005582). And other species homologs or orthologs.
  • the hsa-miR-1228-5p gene can be obtained by the method described in Berezikov E et al., 2007, MolCell, 28, p328-336.
  • “hsa-miR-1228-5p” is known as “hsa-mir-1228” (miRBaseAccession No. MI0006318, SEQ ID NO: 1383) having a hairpin-like structure as a precursor.
  • hsa-miR-4430 gene or “hsa-miR-4430” refers to the hsa-miR-4430 gene (miRBaseAccession No. MIMAT0018945) described in SEQ ID NO: 1341, homologs of other species or Orthologs and the like are included.
  • the hsa-miR-4430 gene can be obtained by the method described in JimDD et al., 2010, Blood, 116, e118-e127.
  • hsa-mir-4430 (miRBaseAccession No. MI0016769, SEQ ID NO: 1384) having a hairpin-like structure as a precursor is known.
  • hsa-miR-296-3p gene or “hsa-miR-296-3p” refers to the hsa-miR-296-3p gene described in SEQ ID NO: 1342 (miRBaseAccession No. MIMAT0004679). And other species homologs or orthologs.
  • the hsa-miR-296-3p gene can be obtained by the method described in Houbaviy HB et al., 2003, DevCell, 5, p351-358.
  • hsa-miR-296-3p “hsa-mir-296” (miRBaseAccession No. MI000047, SEQ ID NO: 1385), which has a hairpin-like structure as a precursor, is known.
  • hsa-miR-1237-5p gene or “hsa-miR-1237-5p” refers to the hsa-miR-1237-5p gene described in SEQ ID NO: 1343 (miRBaseAccessionNo.MIMAT0022946). And other species homologs or orthologs.
  • the hsa-miR-1237-5p gene can be obtained by the method described in Berezikov E et al., 2007, MolCell, 28, p328-336.
  • hsa-mir-1237 miRBaseAccession No. MI0006327, SEQ ID NO: 1386
  • hsa-miR-4466 gene or “hsa-miR-4466” refers to the hsa-miR-4466 gene (miRBaseAccession No. MIMAT0018993) described in SEQ ID NO: 1344 Orthologs and the like are included.
  • the hsa-miR-4466 gene can be obtained by the method described in JimDD et al., 2010, Blood, 116, e118-e127.
  • hsa-mir-4466 (miRBaseAccession No. MI0016817, SEQ ID NO: 1387) having a hairpin-like structure as a precursor is known.
  • hsa-miR-6789-5p gene or “hsa-miR-6789-5p” refers to the hsa-miR-6789-5p gene described in SEQ ID NO: 1345 (miRBaseAccessionNo.MIMAT0027478). And other species homologs or orthologs.
  • the hsa-miR-6789-5p gene is described in Ladewig E et al., 2012, Genome Res. No. 22, p1634-645.
  • hsa-miR-6789-5p “hsa-mir-6789” (miRBaseAccession No. MI0022634, SEQ ID NO: 1388) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4632-5p gene or “hsa-miR-4632-5p” refers to the hsa-miR-4632-5p gene described in SEQ ID NO: 1346 (miRBaseAccession No. MIMAT0022977). And other species homologs or orthologs.
  • the hsa-miR-4632-5p gene can be obtained by the method described in PerssonH et al., 2011, Cancer Res, 71, p78-86.
  • “hsa-miR-4632-5p” is known as “hsa-mir-4632” (miRBaseAccession No. MI0017259, SEQ ID NO: 1389) having a hairpin-like structure as a precursor.
  • hsa-miR-4745-5p gene or “hsa-miR-4745-5p” refer to the hsa-miR-4745-5p gene described in SEQ ID NO: 1347 (miRBaseAccession No. MIMAT0019878). And other species homologs or orthologs.
  • the hsa-miR-4745-5p gene can be obtained by the method described in PerssonH et al., 2011, Cancer Res, 71, p78-86.
  • “Hsa-miR-4745-5p” is known as “hsa-mir-4745” (miRBaseAccession No. MI0017384, SEQ ID NO: 1390) having a hairpin-like structure as a precursor.
  • hsa-miR-4665-5p gene or “hsa-miR-4665-5p” refers to the hsa-miR-4665-5p gene set forth in SEQ ID NO: 1348 (miRBaseAccession No. MIMAT0019739). And other species homologs or orthologs.
  • the hsa-miR-4665-5p gene can be obtained by the method described in PerssonH et al., 2011, Cancer Res, 71, p78-86.
  • “hsa-miR-4665-5p” is known as “hsa-mir-4665” (miRBaseAccession No. MI0017295, SEQ ID NO: 1391), which has a hairpin-like structure as a precursor.
  • hsa-miR-6807-5p gene or “hsa-miR-6807-5p” refers to the hsa-miR-6807-5p gene described in SEQ ID NO: 1349 (miRBaseAccession No. MIMAT0027514). And other species homologs or orthologs.
  • the hsa-miR-6807-5p gene can be obtained by the method described in Ladewig E et al., 2012, GenomeRes, 22, p1634-1645.
  • “hsa-miR-6807-5p” is known as “hsa-mir-6807” (miRBaseAccession No. MI0022652, SEQ ID NO: 1392) having a hairpin-like structure as a precursor.
  • hsa-miR-7114-5p gene or “hsa-miR-7114-5p” refers to the hsa-miR-7114-5p gene described in SEQ ID NO: 1350 (miRBaseAccessionNo.MIMAT0028125). And other species homologs or orthologs.
  • the hsa-miR-7114-5p gene can be obtained by the method described in Ladewig E et al., 2012, GenomeRes, 22, p1634-1645.
  • “hsa-miR-7114-5p” “hsa-mir-7114” (miRBaseAccession No. MI0022965, SEQ ID NO: 1393) having a hairpin-like structure as a precursor is known.
  • hsa-miR-150-3p gene or “hsa-miR-150-3p” refers to the hsa-miR-150-3p gene described in SEQ ID NO: 1351 (miRBaseAccession No. MIMAT0004610). And other species homologs or orthologs.
  • the hsa-miR-150-3p gene can be obtained by the method described in Lagos-QuintanaM et al., 2002, CurrBiol, 12, p735-739.
  • “hsa-miR-150-3p” “hsa-mir-150” (miRBaseAccession No. MI0000479, SEQ ID NO: 1394) having a hairpin-like structure as a precursor is known.
  • hsa-miR-423-5p gene or “hsa-miR-423-5p” refers to the hsa-miR-423-5p gene described in SEQ ID NO: 1352 (miRBaseAccessionNo.MIMAT0004748). And other species homologs or orthologs.
  • the hsa-miR-423-5p gene can be obtained by the method described in Kasshima K et al., 2004, Biochem Biophys ResCommun, 322, p403-410.
  • “hsa-miR-423-5p” “hsa-mir-423” (miRBaseAccession No. MI0001445, SEQ ID NO: 1395) having a hairpin-like structure as a precursor is known.
  • hsa-miR-575 gene or “hsa-miR-575” refers to the hsa-miR-575 gene (miRBaseAccession No. MIMAT0003240) described in SEQ ID NO: 1353 or other species homolog Orthologs and the like are included.
  • the hsa-miR-575 gene can be obtained by the method described in Cummins JM et al., 2006, ProcNatlAcadSciUSA, 103, p3687-3692.
  • hsa-miR-575 “hsa-mir-575” (miRBaseAccession No. MI0003582, SEQ ID NO: 1396) having a hairpin-like structure as a precursor is known.
  • hsa-miR-671-5p gene or “hsa-miR-671-5p” refers to the hsa-miR-671-5p gene described in SEQ ID NO: 1354 (miRBaseAccession No. MIMAT0003880). And other species homologs or orthologs.
  • the hsa-miR-671-5p gene is described in Berezikov E et al., 2006, Genome Res. 16, p. 1299-1298.
  • “hsa-miR-671-5p” is known as “hsa-mir-671” (miRBaseAccession No. MI0003760, SEQ ID NO: 1397), which has a hairpin-like structure as a precursor.
  • hsa-miR-939-5p gene or “hsa-miR-939-5p” refers to the hsa-miR-939-5p gene described in SEQ ID NO: 1355 (miRBaseAccession No. MIMAT0004982). And other species homologs or orthologs.
  • the hsa-miR-939-5p gene is described in LuiWO et al., 2007, Cancer Res. 67, p6031-6043.
  • hsa-mir-939 miRBaseAccession No. MI0005761, SEQ ID NO: 1398) having a hairpin-like structure as a precursor is known.
  • hsa-miR-3665 gene or “hsa-miR-3665” refers to the hsa-miR-3665 gene (miRBaseAccession No. MIMAT0018087) described in SEQ ID NO: 1356 or other species homolog or Orthologs and the like are included.
  • the hsa-miR-3665 gene can be obtained by the method described in XieX et al., 2005, Nature, 434, p338-345.
  • hsa-miR-3665 “hsa-mir-3665” (miRBaseAccession No. MI0016066, SEQ ID NO: 1399) having a hairpin-like structure as a precursor is known.
  • hsa-miR-516a-5p gene or “hsa-miR-516a-5p” refers to the hsa-miR-516a-5p gene described in SEQ ID NO: 1435 (miRBase Accession No. 1). MIMAT0004770) and other species homologs or orthologs.
  • the hsa-miR-516a-5p gene was obtained from Bentwich I et al., 2005, Nat Genet. 37, 766-770.
  • “hsa-miR-516a-5p” is known as “hsa-miR-516a-1” (miRBase Accession No. MI0003180, SEQ ID NO: 1454) having a hairpin-like structure as a precursor.
  • hsa-miR-769-3p gene or “hsa-miR-769-3p” refers to the hsa-miR-769-3p gene (miRBase Accession No. 1) described in SEQ ID NO: 1436. MIMAT0003887) and other species homologues or orthologues are included.
  • the hsa-miR-769-3p gene was obtained from Berezikov E et al., 2006, Genome Res. 16 can be obtained by the method described in 1289-1298.
  • “hsa-miR-769-3p” is known as “hsa-miR-769-3p” (miRBase Accession No. MI0003834, SEQ ID NO: 1465) having a hairpin-like structure as a precursor.
  • hsa-miR-3692-5p gene or “hsa-miR-3692-5p” refers to the hsa-miR-3692-5p gene (miRBase Accession No. 1) described in SEQ ID NO: 1437. MIMAT0018121) and other species homologues or orthologues are included.
  • the hsa-miR-3692-5p gene is disclosed in Vaz C et al., 2010, BMC Genomics. , 11 and 288.
  • “hsa-miR-3692-5p” is known as “hsa-miR-3692-5p” (miRBase Accession No. MI0016093, SEQ ID NO: 1456), which has a hairpin-like structure as a precursor.
  • hsa-miR-3945 gene or “hsa-miR-3945” refers to the hsa-miR-3945 gene (miRBase Accession No. MIMAT0018361) described in SEQ ID NO: 1438 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-3945 gene was found in Liao JY et al., 2010, PLoS One. 5 and can be obtained by the method described in e10563.
  • “hsa-miR-3945” “hsa-miR-3945” (miRBase Accession No. MI0016602, SEQ ID NO: 1457) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4433a-3p gene or “hsa-miR-4433a-3p” refers to the hsa-miR-4433a-3p gene (miRBase Accession No. 1) described in SEQ ID NO: 1439. MIMAT0018949) and other species homologs or orthologs.
  • the hsa-miR-4433a-3p gene is described in Jim DD et al., 2010, Blood. 116, e118-e127.
  • “hsa-miR-4433a-3p” is known as “hsa-miR-4433a-3p” (miRBase Accession No. MI0016773, SEQ ID NO: 1458) having a hairpin-like structure as a precursor.
  • hsa-miR-4485-3p gene or “hsa-miR-4485-3p” refers to the hsa-miR-4485-3p gene described in SEQ ID NO: 1440 (miRBase Accession No. MIMAT0019019) and other species homologues or orthologues are included.
  • the hsa-miR-4485-3p gene is described in Jim DD et al., 2010, Blood. 116, e118-e127.
  • “hsa-miR-4485-3p” is known as “hsa-miR-4485-3p” (miRBase Accession No. MI0016846, SEQ ID NO: 1459) having a hairpin-like structure as a precursor.
  • hsa-miR-6831-5p gene or “hsa-miR-6831-5p” refers to the hsa-miR-6831-5p gene described in SEQ ID NO: 1441 (miRBase Accession No. MIMAT0027562) and other species homologues or orthologues are included.
  • the hsa-miR-6831-5p gene is described in Ladewig E et al., 2012, Genome Res. , Vol. 22, 1634-1645.
  • “hsa-miR-6831-5p” is known as “hsa-miR-6831-5p” (miRBase Accession No. MI0022676, SEQ ID NO: 1460) having a hairpin-like structure as a precursor.
  • hsa-miR-519c-5p gene or “hsa-miR-519c-5p” refers to the hsa-miR-519c-5p gene described in SEQ ID NO: 1442 (miRBase Accession No. MIMAT0002831) and other species homologs or orthologs are included.
  • the hsa-miR-519c-5p gene was obtained from Bentwich I et al., 2005, Nat Genet. 37, 766-770.
  • “hsa-miR-519c-5p” “hsa-miR-519c-5p” (miRBase Accession No. MI0003148, SEQ ID NO: 1461) having a hairpin-like structure as a precursor is known.
  • hsa-miR-551b-5p gene or “hsa-miR-551b-5p” refers to the hsa-miR-551b-5p gene (miRBase Accession No. 1) described in SEQ ID NO: 1443. MIMAT0004794) and other species homologs or orthologs.
  • the hsa-miR-551b-5p gene was found in Cummins JM et al., 2006, Proc Natl Acad Sci US A. 103, 3687-3692 can be obtained.
  • “hsa-miR-551b-5p” “hsa-miR-551b-5p” (miRBase Accession No. MI0003575, SEQ ID NO: 1462) having a hairpin-like structure as a precursor is known.
  • hsa-miR-1343-3p gene or “hsa-miR-1343-3p” refers to the hsa-miR-1343-3p gene (miRBase Accession No. 1) described in SEQ ID NO: 1444. MIMAT0019776) and other species homologs or orthologs.
  • the hsa-miR-1343-3p gene is disclosed in Persson H et al., 2011, Cancer Res. , 71, 78-86.
  • “Hsa-miR-1343-3p” is known as “hsa-miR-1343-3p” (miRBase Accession No. MI0017320, SEQ ID NO: 1463) having a hairpin-like structure as a precursor.
  • hsa-miR-4286 gene or “hsa-miR-4286” refers to the hsa-miR-4286 gene (miRBase Accession No. MIMAT0016916) described in SEQ ID NO: 1445 or other biological species. Homologs or orthologs are included. The hsa-miR-4286 gene was found in Goff LA et al., 2009, PLoS One. 4 can be obtained by the method described in e7192. As for “hsa-miR-4286”, “hsa-miR-4286” (miRBase Accession No. MI0015894, SEQ ID NO: 1464) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4634 gene or “hsa-miR-4634” refers to the hsa-miR-4634 gene (miRBase Accession No. MIMAT0019691) described in SEQ ID NO: 1446 or other biological species. Homologs or orthologs are included.
  • the hsa-miR-4634 gene is disclosed in Persson H et al., 2011, Cancer Res. , 71, 78-86.
  • hsa-miR-4634 “hsa-miR-4634” (miRBase Accession No. MI0017261, SEQ ID NO: 1465) having a hairpin-like structure as a precursor is known.
  • hsa-miR-4733-3p gene or “hsa-miR-4733-3p” refers to the hsa-miR-4733-3p gene (miRBase Accession No. 1) described in SEQ ID NO: 1447. MIMAT0019858) and other species homologs or orthologs.
  • the hsa-miR-4733-3p gene is disclosed in Persson H et al., 2011, Cancer Res. , 71, 78-86.
  • “hsa-miR-4733-3p” is known as “hsa-miR-4733-3p” (miRBase Accession No. MI0017370, SEQ ID NO: 1466) having a hairpin-like structure as a precursor.
  • hsa-miR-6086 gene or “hsa-miR-6086” refers to the hsa-miR-6086 gene (miRBase Accession No. MIMAT0023711) described in SEQ ID NO: 1448 and other biological species. Homologs or orthologs are included.
  • the hsa-miR-6086 gene was obtained from Yoo JK et al., 2012, Stem Cells Dev. 21 and 2049-2057.
  • hsa-miR-6086 is known as “hsa-miR-6086” (miRBase Accession No. MI0020363, SEQ ID NO: 1467) having a hairpin-like structure as a precursor.
  • hsa-miR-30d-5p gene or “hsa-miR-30d-5p” refers to the hsa-miR-30d-5p gene described in SEQ ID NO: 1449 (miRBase Accession No. MIMAT000045) and other species homologues or orthologues are included.
  • the hsa-miR-30d-5p gene was obtained from Lagos-Quintana M et al., 2002, Curr Biol. , Vol. 12, 735-739.
  • “hsa-miR-30d-5p” is known as “hsa-miR-30d-5p” (miRBase Accession No. MI0000255, SEQ ID NO: 1468) having a hairpin-like structure as a precursor.
  • hsa-miR-30b-3p gene or “hsa-miR-30b-3p” refers to the hsa-miR-30b-3p gene (miRBase Accession No. 1) described in SEQ ID NO: 1450. MIMAT0004589) and other species homologues or orthologues are included.
  • the hsa-miR-30b-3p gene was obtained from Lagos-Quintana M et al., 2002, Curr Biol. , Vol. 12, 735-739.
  • “hsa-miR-30b-3p” is known as “hsa-miR-30b-3p” (miRBase Accession No. MI000000441, SEQ ID NO: 1469) having a hairpin-like structure as a precursor.
  • hsa-miR-92a-3p gene or “hsa-miR-92a-3p” refers to the hsa-miR-92a-3p gene (miRBase Accession No. 1) described in SEQ ID NO: 1451. MIMAT00000092) and other species homologs or orthologs.
  • the hsa-miR-92a-3p gene is described in Mouretos Z et al., 2002, Genes Dev. 16 can be obtained by the method described in 720-728.
  • “hsa-miR-92a-3p” is known as “hsa-miR-92a-3p” (miRBase Accession No. MI00000093, SEQ ID NO: 1470) having a hairpin-like structure as a precursor.
  • hsa-miR-371b-5p gene or “hsa-miR-371b-5p” refers to the hsa-miR-371b-5p gene described in SEQ ID NO: 1452 (miRBase Accession No. MIMAT0019892) and other species homologs or orthologs are included.
  • the hsa-miR-371b-5p gene is described in Persson H et al., 2011, Cancer Res. , 71, 78-86.
  • “hsa-miR-371b-5p” is known as “hsa-miR-371b-5p” (miRBase Accession No. MI0017393, SEQ ID NO: 1471) having a hairpin-like structure as a precursor.
  • hsa-miR-486-5p gene or “hsa-miR-486-5p” refers to the hsa-miR-486-5p gene (miRBase Accession No. 1) described in SEQ ID NO: 1453. MIMAT0002177) and other species homologues or orthologues are included.
  • the hsa-miR-486-5p gene was obtained from Fu H et al., 2005, FEBS Lett. 579, 3849-3854.
  • “hsa-miR-486-5p” “hsa-miR-486-5p” (miRBase Accession No. MI0002470, SEQ ID NO: 1472) having a hairpin-like structure as a precursor is known.
  • mature miRNA When mature miRNA is cleaved as a mature miRNA from an RNA precursor having a hairpin-like structure, one to several bases before or after the sequence may be cut out, or may be mutated due to base substitution. It can become a body and is referred to as isomiR (Morin RD. Et al., 2008, Genome Res., Vol. 18, p.610-621).
  • miRBBase version 21
  • any of a number of SEQ ID NOs: 783-1314 called isomiR variants and fragments of the base sequence represented by These mutants can also be obtained as miRNA having the base sequence represented by any of SEQ ID NOs: 1-210, 211-249, 250-374, and 375-390. That is, SEQ ID NOs: 3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 15, 16, 17, 19, 22, 23, 25, 26, 28, 29, 30, 31 of the present invention.
  • polynucleotide examples include sequences represented by 208, 213, 218, 235, 350, and 386.
  • the polynucleotides that are numerous isomiRs of SEQ ID NOs: 1-210, 211-249, 250-374, and 375-390 registered in miRBase can be mentioned.
  • examples of the polynucleotide containing the base sequence represented by any one of SEQ ID NOs: 1-210, 211-249, 250-374, and 375-390 include any of SEQ ID NOs: 391 to 782, which are precursors, respectively.
  • the polynucleotide represented by these is mentioned.
  • miRBBase version 21
  • miRBBase version 21
  • a number of sequence numbers called isomiR Variants and fragments of the nucleotide sequences represented by any of 1015 to 1017, 1019 to 1024, 1026 to 1031, 1285 to 1286, and 1400 to 1434 are also shown.
  • miRNAs having the base sequences represented by any of SEQ ID NOs: 194 to 210, 374, and 1315 to 1350, and 211 to 212 and 1351 to 1356.
  • the longest mutant registered in 21) includes a polynucleotide represented by SEQ ID NO: 1427.
  • the shortest variants are SEQ ID NOs: 1017, 1020, 1405, 1022, 1407, 1409, 1411, 1024, 1027, 1415, 1417, 1418, 1419, 1029, 1421, 1428, 1430, 1432, respectively.
  • a polynucleotide having the sequence represented by 1434 there are polynucleotides that are registered in miRBase and are numerous isomiRs of SEQ ID NOs: 194 to 210, 374, and 1315 to 1350, and 211 to 212 and 1351 to 1356. .
  • the precursors of SEQ ID NOs: 398 and 490 are used. , 591, 593 to 609, 766, and 1357 to 1399.
  • miRBBase version 21
  • isomiR Mutants and fragments of are also shown. These mutants can also be obtained as miRNA having the base sequence represented by any of SEQ ID NOs: 1435 to 1448 and 1449 to 1453.
  • polynucleotide variants having a base sequence in which u is t in the sequence for example, the longest variant registered in miRBBase (Version 21) includes the polynucleotide represented by SEQ ID NO: 1496.
  • examples of the shortest mutant include polynucleotides having sequences represented by SEQ ID NOs: 1494, 1501, and 1505, respectively.
  • polynucleotides that are numerous isomiRs of SEQ ID NOs: 1435 to 1448 and 1449 to 1453 registered in miRBase can be mentioned.
  • polynucleotide containing the base sequence represented by any one of SEQ ID NOs: 1435 to 1448 and 1449 to 1453 the polynucleotide represented by any one of SEQ ID NOs: 1454 to 1467 and 1468 to 1472 as precursors Nucleotides are mentioned.
  • nucleic acid probe or primer used in the present invention binds to a specific target nucleic acid and cannot substantially bind to another nucleic acid.
  • the present invention it is possible to detect dementia of a wide range of disease types comprehensively with high accuracy (or AUC), sensitivity, and specificity, and to distinguish between dementia and normal cognitive function (non-dementia). Become.
  • AUC accuracy
  • sensitivity sensitivity
  • specificity sensitivity
  • specificity sensitivity
  • specificity sensitivity
  • specificity sensitivity
  • specificity normal cognitive function
  • a dementia disease type easily and without differences between doctors and medical institutions. For example, whether or not a subject is easily demented by using as an index a measured value of the expression level of one or more to several miRNAs in the blood, serum and / or plasma of a subject that can be collected minimally invasively Can be detected.
  • FIG. 1 shows hsa-miR-4728-5p represented by SEQ ID NO: 3 generated from hsa-mir-4728 represented by SEQ ID NO: 393, and hsa-miR represented by SEQ ID NO: 335. This shows the relationship of the base sequence of ⁇ 4728-3p.
  • FIG. 2 is a discrimination score diagram of the learning sample group and the verification sample group obtained in Example 1. 2A shows Alzheimer's dementia obtained in Example 1-1, FIG. 2B shows vascular dementia obtained in Example 1-2, and FIG. 2C shows Lewy body type recognition obtained in Example 1-3. FIG. FIG. FIG. FIG.
  • FIG. 3 is a discrimination score diagram of the learning sample group (A) and the verification sample group (B) obtained in Example 2-1, and ROC curves of the learning sample group (C) and the verification sample group (D).
  • FIG. 4 is a discrimination score diagram of the learning sample group (A) and the verification sample group (B) obtained in Example 2-2, and the ROC curves of the learning sample group (C) and the verification sample group (D).
  • FIG. 5 is a discrimination score diagram of the learning sample group (A) and the verification sample group (B) obtained in Example 2-3, and the ROC curves of the learning sample group (C) and the verification sample group (D).
  • FIG. 6 is a discrimination score diagram of the learning sample group (A) and the verification sample group (B) obtained in Example 2-4, and ROC curves of the learning sample group (C) and the verification sample group (D).
  • FIG. 7 is a discrimination score diagram of the learning sample group (A) and the verification sample group (B) obtained in Example 2-5, and ROC curves of the learning sample group (C) and the verification sample group (D).
  • FIG. 8 is a discrimination score diagram of the learning sample group (A) and the verification sample group (B) obtained in Example 3-1, and ROC curves of the learning sample group (C) and the verification sample group (D).
  • FIG. 9 is a discrimination score diagram of the learning sample group (A) and the verification sample group (B) obtained in Example 3-2, and ROC curves of the learning sample group (C) and the verification sample group (D).
  • FIG. 10 is a discrimination score diagram of the learning sample group (A) and the verification sample group (B) obtained in Example 3-3, and the ROC curve of the learning sample group (C) and the verification sample group (D).
  • FIG. 11 is a discrimination score diagram of the learning sample group (A) and the verification sample group (B) obtained in Example 3-4, and ROC curves of the learning sample group (C) and the verification sample group (D).
  • FIG. 12 is a discrimination score diagram of the learning sample group (A) and the verification sample group (B) obtained in Example 3-5, and ROC curves of the learning sample group (C) and the verification sample group (D).
  • FIG. 13 is an ROC curve of the verification sample group obtained in Example 9.
  • FIG. 13A shows Alzheimer type dementia obtained in Example 9-1
  • FIG. 13B shows vascular dementia obtained in Example 9-2
  • FIG. 13C shows Lewy body type recognition obtained in Example 9-3.
  • FIG. FIG. 14 shows the nucleotide sequence of hsa-miR-6765-5p generated from hsa-mir-6765 represented by SEQ ID NO: 490, and hsa-miR-6765-3p represented by SEQ ID NO: 1315. The relationship is shown.
  • FIG. 15 is a discrimination score diagram of the learning sample group (A) and the verification sample group (B) obtained in Example 15.
  • FIG. 16 is a discrimination score diagram of the learning sample group (A) and the verification sample group (B) obtained in Example 20.
  • FIG. 17 is a diagram showing the ROC curve obtained in Example 21.
  • FIG. 17A is an ROC in which the sensitivity calculated using 42 miRNA markers obtained in Example 15 and 51 miRNA markers obtained in Example 20 are plotted on the vertical axis and the specificity is plotted on the horizontal axis. It is a curve.
  • FIG. 18A is a discrimination score diagram of the verification sample group using 44 miRNA markers obtained in Example 24, and
  • FIG. 18B is a longitudinal graph showing the sensitivity calculated using 44 miRNA markers obtained in Example 24. It is a ROC curve with the axis representing the specificity and the abscissa representing the specificity.
  • Target nucleic acid for dementia Main target nucleic acid as a dementia marker for detecting the presence or absence of dementia or dementia using the nucleic acid probe or primer for detection of dementia as defined above of the present invention (I) miR-4274, miR-4272, miR-4728-5p, miR-4443, miR-4506, miR-6773-5p, miR-4662a-5p, miR-3184-3p, miR-4281, miR-320d, miR-6729-3p, miR-5192, miR-6683-5p, miR-1234-3p, miR-12233-3p, miR-4539, miR-3914, miR-4438-5p, miR-548au- 3p, miR-1539, miR-4720-3p, miR-365b-5p, miR-4 486, miR-1227-5p, miR-4667-5p, miR-6088, miR-6820-5p, miR-4505, miR-548q, miR-4658, miR-
  • miRNAs that can be combined with these miRNA (i): (ii) miR-1225-3p, miR-3184-5p, miR-665, miR-211-5p, miR-1247-5p MiR-3656, miR-149-5p, miR-744-5p, miR-345-5p, miR-150-5p, miR-191-3p, miR-651-5p, miR-34a-5p, miR-409 -5p, miR-369-5p, miR-1915-5p, miR-204-5p, miR-137, miR-382-5p, miR-517-5p, miR-532-5p, miR-22-5p, miR -1237-3p, miR-1224-3p, miR-625-3p, miR-328-3p, miR 122-5p, miR-202-3p, miR-4781-5p, miR-718, miR-342-3p, miR-26b-3p, miR-140-3p, miR-200a-3p, miRNA
  • miRNA-4728-5p miRNA (i) to (ii) or separately from the miRNA (i) to (ii), (iii) miR-4728-5p, miR-3184-3p, miR-12233-3p, miR- 6088, miR-6777-3p, miR-7110-3p, miR-936, miR-6087, miR-1202, miR-4731-3p, miR-4800-5p, miR-6784-3p, miR-4716-5p, miR-6734-3p, miR-6889-3p, miR-6867-3p, miR-3622a-3p, miR-6813-3p, miR-4769-3p, miR-5698, miR-3184-5p, miR-1471, miR-1538, miR-449b-3p, miR-1976, miR-4268, m R-4279, miR-3620-3p, miR-3944-3p, miR-3156-3p, miR-3187-5p, miR-44
  • Other dementia markers that can be combined with the miRNAs (i) to (iii) include: (iv) miR-766-3p, miR-1229-3p, miR-1306-5p, miR-210-5p, miR- 198, miR-485-3p, miR-668-3p, miR-532-3p, miR-877-3p, miR-1238-3p, miR-3130-5p, miR-4298, miR-4290, miR-3343, One, two, three or more, ten or more, preferably three to 110 miRNAs selected from the group consisting of miR-346 and miR-767-3p can also be preferably used as the target nucleic acid.
  • the miRNA includes, for example, a nucleotide sequence represented by any one of SEQ ID NOs: 1-210, 211-249, 250-374, 375-390, 1315-1350, 1351-1356, 1435-1448, 1449-1453 (I.e., miR-4274, miR-4272, miR-4728-5p, miR-4443, miR-4506, miR-6773-5p, miR-4662a-5p, miR-3184-3p, miR, respectively) -4281, miR-320d, miR-6729-3p, miR-5192, miR-6683-5p, miR-1234-3p, miR-1233-3p, miR-4539, miR-3914, miR-4438-5p, miR -548au-3p, miR-1539, iR-4720-3p, miR-365b-5p, miR-4486, miR-1227-5p, miR-4667-5p, miR-6088, miR-6820
  • Preferred target nucleic acids include the nucleotide sequences represented by any of SEQ ID NOs: 1-210, 211-249, 250-374, and 375-390, 1315-1350, 1351-1356, 1435-1448, 1449-1453. It is a human gene, its transcription product, more preferably the transcription product, ie, miRNA, its precursor RNA, pri-miRNA or pre-miRNA.
  • the nucleic acid probe or primer for detecting dementia as defined above of the present invention is used as a major dementia marker for detecting the presence or absence of dementia or dementia.
  • the target nucleic acids include miR-5698, miR-1915-3p, miR-1343-5p, miR-6861-5p, miR-6781-5p, miR-4508, miR-6743-5p, miR-6726-5p, miR -4525, miR-4651, miR-6683-5p, miR-5787, miR-1290, miR-6075, miR-4758-5p, miR-4690-5p, miR-762, miR-371a-5p, miR-6765 -3p, miR-6784-5p, miR-6778-5p, miR-6875-5p miR-4534, miR-4721, miR-6756-5p, miR-615-5p, miR-6727-5p, miR-6687-5p, miR-8063, miR-68
  • the miRNA includes, for example, human genes containing the nucleotide sequences represented by any of SEQ ID NOs: 194 to 210, 374, and 1315 to 1350, and 211 to 212 and 1351 to 1356 (ie, miR-5698, respectively).
  • the target nucleic acid is a human gene comprising a nucleotide sequence represented by any of SEQ ID NOs: 194 to 210, 374, and 1315 to 1350, and 211 to 212 and 1351 to 1356, a transcription product thereof, more preferably Is the transcript, ie miRNA, its precursor RNA, pri-miRNA or pre-miRNA.
  • the first target gene is the hsa-miR-4274 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the second target gene is the hsa-miR-4272 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the third target gene is the hsa-miR-4728-5p gene, their homologues, their transcripts, or their mutants or derivatives. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the fourth target gene is the hsa-miR-4443 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the fifth target gene is the hsa-miR-4506 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the sixth target gene is the hsa-miR-6773-5p gene, their homologues, their transcription products, or their mutants or derivatives. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the seventh target gene is the hsa-miR-4662a-5p gene, their homologues, their transcription products, or their mutants or derivatives. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the eighth target gene is the hsa-miR-3184-3p gene, their homologues, their transcripts, or their mutants or derivatives. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the ninth target gene is the hsa-miR-4281 gene, their homologs, their transcripts, or their mutants or derivatives. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the tenth target gene is the hsa-miR-320d gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the eleventh target gene is the hsa-miR-6729-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the twelfth target gene is the hsa-miR-5192 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the thirteenth target gene is an hsa-miR-6683-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 14th target gene is an hsa-miR-1234-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the fifteenth target gene is the hsa-miR-1233-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the sixteenth target gene is an hsa-miR-4539 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 17th target gene is the hsa-miR-3914 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 18th target gene is the hsa-miR-4738-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the nineteenth target gene is the hsa-miR-548au-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the twentieth target gene is the hsa-miR-1539 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 21st target gene is the hsa-miR-4720-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 22nd target gene is the hsa-miR-365b-5p gene, their homologues, their transcripts, or their mutants or derivatives. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 23rd target gene is the hsa-miR-4486 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 24th target gene is the hsa-miR-1227-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 25th target gene is the hsa-miR-4667-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the twenty-sixth target gene is the hsa-miR-6088 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 27th target gene is the hsa-miR-6820-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 28th target gene is the hsa-miR-4505 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 29th target gene is the hsa-miR-548q gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 30th target gene is the hsa-miR-4658 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the thirty-first target gene is the hsa-miR-450a-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the thirty-second target gene is the hsa-miR-1260b gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 33rd target gene is the hsa-miR-3777-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 34th target gene is the hsa-miR-6777-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 35th target gene is the hsa-miR-6826-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the thirty-sixth target gene is the hsa-miR-6683-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 37th target gene is the hsa-miR-4725-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 38th target gene is the hsa-miR-7161-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 39th target gene is the hsa-miR-2277-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 40th target gene is the hsa-miR-7110-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 41st target gene is the hsa-miR-4312 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the forty second target gene is the hsa-miR-4461 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 43rd target gene is the hsa-miR-6766-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 44th target gene is the hsa-miR-1266-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 45th target gene is the hsa-miR-6729-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 46th target gene is the hsa-miR-526b-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 47th target gene is an hsa-miR-519e-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 48th target gene is the hsa-miR-512-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 49th target gene is an hsa-miR-5088-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 50th target gene is the hsa-miR-1909-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 51st target gene is the hsa-miR-6511a-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 52nd target gene is the hsa-miR-4734 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 53rd target gene is the hsa-miR-936 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 54th target gene is the hsa-miR-1249-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 55th target gene is the hsa-miR-6777-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 56th target gene is the hsa-miR-4487 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 57th target gene is the hsa-miR-3155a gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 58th target gene is the hsa-miR-563 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 59th target gene is the hsa-miR-4741 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 60th target gene is the hsa-miR-6788-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 61st target gene is the hsa-miR-4433b-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 62nd target gene is the hsa-miR-323a-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 63rd target gene is an hsa-miR-6811-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 64th target gene is the hsa-miR-6721-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 65th target gene is the hsa-miR-5004-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 66th target gene is the hsa-miR-6509-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 67th target gene is the hsa-miR-648 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 68th target gene is the hsa-miR-3913 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 69th target gene is the hsa-miR-6087 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 70th target gene is an hsa-miR-1470 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 71st target gene is an hsa-miR-586 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 72nd target gene is the hsa-miR-3150a-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 73rd target gene is the hsa-miR-105-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 74th target gene is the hsa-miR-7793 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 75th target gene is the hsa-miR-1914-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 76th target gene is the hsa-miR-4749-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 77th target gene is the hsa-miR-15b-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 78th target gene is the hsa-miR-1289 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 79th target gene is the hsa-miR-4433a-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 80th target gene is the hsa-miR-3666 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 81st target gene is the hsa-miR-3186-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 82nd target gene is the hsa-miR-4725-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 83rd target gene is the hsa-miR-4488 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 84th target gene is the hsa-miR-4474-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 85th target gene is the hsa-miR-6673-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 86th target gene is the hsa-miR-4640-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 87th target gene is the hsa-miR-202-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 88th target gene is the hsa-miR-6816-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 89th target gene is the hsa-miR-638 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 90th target gene is the hsa-miR-6821-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 91st target gene is the hsa-miR-1247-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 92nd target gene is the hsa-miR-6765-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 93rd target gene is an hsa-miR-6800-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 94th target gene is the hsa-miR-3928-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 95th target gene is the hsa-miR-3940-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 96th target gene is the hsa-miR-3960 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 97th target gene is the hsa-miR-6775-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 98th target gene is the hsa-miR-3178 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 99th target gene is the hsa-miR- 1202 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 100th target gene is the hsa-miR-6790-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 101st target gene is the hsa-miR-4731-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 102nd target gene is the hsa-miR-2681-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 103rd target gene is the hsa-miR-6758-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 104th target gene is the hsa-miR-8072 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 105th target gene is the hsa-miR-518d-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 106th target gene is the hsa-miR-3606-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 107th target gene is the hsa-miR-4800-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 108th target gene is the hsa-miR-1292-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 109th target gene is the hsa-miR-6784-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 110th target gene is the hsa-miR-4450 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 111th target gene is the hsa-miR-6132 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 112th target gene is the hsa-miR-4716-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 113th target gene is the hsa-miR-6860 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 114th target gene is the hsa-miR-1268b gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 115th target gene is the hsa-miR-378d gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 116th target gene is the hsa-miR-4701-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 117th target gene is the hsa-miR-4329 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 118th target gene is the hsa-miR-185-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 119th target gene is the hsa-miR-552-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 120th target gene is the hsa-miR-1273g-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 121st target gene is the hsa-miR-6769b-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 122nd target gene is the hsa-miR-520a-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 123rd target gene is the hsa-miR-4524b-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 124th target gene is the hsa-miR-4291 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 125th target gene is the hsa-miR-6734-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 126th target gene is the hsa-miR-143-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 127th target gene is the hsa-miR-939-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 128th target gene is the hsa-miR-6889-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 129th target gene is the hsa-miR-6842-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 130th target gene is the hsa-miR-4511 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 131st target gene is the hsa-miR-4318 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 132nd target gene is the hsa-miR-4653-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 133rd target gene is the hsa-miR-6867-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 134th target gene is the hsa-miR-133b gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 135th target gene is the hsa-miR-3196 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 136th target gene is the hsa-miR-193b-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 137th target gene is the hsa-miR-3162-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 138th target gene is the hsa-miR-6819-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 139th target gene is the hsa-miR-1908-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 140th target gene is the hsa-miR-6786-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 141st target gene is the hsa-miR-3648 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 142nd target gene is the hsa-miR-4513 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the target gene 143 is the hsa-miR-3652 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 144th target gene is the hsa-miR-4640-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 145th target gene is the hsa-miR-6871-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 146th target gene is the hsa-miR-7845-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 147th target gene is the hsa-miR-3138 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 148th target gene is the hsa-miR-6884-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 149th target gene is the hsa-miR-4653-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 150th target gene is the hsa-miR-636 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 151st target gene is the hsa-miR-4652-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 152th target gene is the hsa-miR-6823-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 153rd target gene is the hsa-miR-4502 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 154th target gene is the hsa-miR-7113-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 155th target gene is the hsa-miR-8087 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 156th target gene is the hsa-miR-7154-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 157th target gene is the hsa-miR-5189-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 158th target gene is the hsa-miR-1253 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 159th target gene is the hsa-miR-518c-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 160th target gene is the hsa-miR-7151-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 161st target gene is the hsa-miR-3614-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 162nd target gene is the hsa-miR-4727-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 163rd target gene is the hsa-miR-3682-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 164th target gene is an hsa-miR-5090 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 165th target gene is the hsa-miR-337-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 166th target gene is the hsa-miR-488-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 167th target gene is an hsa-miR-100-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 168th target gene is the hsa-miR-4520-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 169th target gene is the hsa-miR-373-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 170th target gene is the hsa-miR-6499-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 171st target gene is the hsa-miR-3909 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 172nd target gene is the hsa-miR-32-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 173rd target gene is the hsa-miR-302a-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 174th target gene is the hsa-miR-4686 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 175th target gene is the hsa-miR-4659a-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 176th target gene is the hsa-miR-4287 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 177th target gene is an hsa-miR-1301-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 178th target gene is the hsa-miR-593-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 179th target gene is the hsa-miR-517a-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 180th target gene is the hsa-miR-517b-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the target gene 181 is the hsa-miR-142-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 182nd target gene is the hsa-miR-1185-2-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 183rd target gene is an hsa-miR-602 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 184th target gene is the hsa-miR-527 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 185th target gene is the hsa-miR-518a-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 186th target gene is the hsa-miR-4682 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 187th target gene is an hsa-miR-28-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 188th target gene is the hsa-miR-4252 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 189th target gene is the hsa-miR-452-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 190th target gene is the hsa-miR-525-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 191st target gene is the hsa-miR-3622a-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 192nd target gene is the hsa-miR-6813-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 193rd target gene is the hsa-miR-4769-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 194th target gene is the hsa-miR-5698 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 195th target gene is the hsa-miR-1915-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 196th target gene is the hsa-miR-1343-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 197th target gene is the hsa-miR-6861-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 198th target gene is the hsa-miR-6781-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 199th target gene is the hsa-miR-4508 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 200th target gene is the hsa-miR-6743-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 201st target gene is the hsa-miR-6726-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 202nd target gene is the hsa-miR-4525 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 203rd target gene is the hsa-miR-4651 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 204th target gene is the hsa-miR-6813-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 205th target gene is the hsa-miR-5787 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 206th target gene is an hsa-miR-1290 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 207th target gene is the hsa-miR-6075 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 208th target gene is the hsa-miR-4758-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 209th target gene is the hsa-miR-4690-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 210th target gene is the hsa-miR-762 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 211st target gene is the hsa-miR-1225-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 212th target gene is the hsa-miR-3184-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 213rd target gene is the hsa-miR-665 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 3).
  • the 214th target gene is the hsa-miR-211-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • the 215th target gene is the hsa-miR-1247-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 216th target gene is the hsa-miR-3656 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a report that changes in the expression of a gene or a transcription product thereof can be a marker for dementia Patent Document 7).
  • the 217th target gene is the hsa-miR-149-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 218th target gene is the hsa-miR-744-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 6).
  • the 219th target gene is the hsa-miR-345-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 3).
  • the 220th target gene is an hsa-miR-150-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a report that changes in the expression of a gene or a transcription product thereof can be a marker for dementia Patent Document 7).
  • the target gene 221 is the hsa-miR-191-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a report that changes in the expression of a gene or a transcription product thereof can be a marker for dementia Patent Document 2.
  • the 222nd target gene is the hsa-miR-651-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • the 223rd target gene is the hsa-miR-34a-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • the 224th target gene is an hsa-miR-409-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 225th target gene is the hsa-miR-369-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 226th target gene is the hsa-miR-1915-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 227th target gene is the hsa-miR-204-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 228th target gene is the hsa-miR-137 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 4).
  • the 229th target gene is the hsa-miR-382-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 3).
  • the 230th target gene is an hsa-miR-517-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • the target gene 231 is the hsa-miR-532-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a homologue thereof a transcription product thereof, or a mutant or derivative thereof.
  • changes in the expression of genes or their transcripts can serve as markers for dementia (US Patent Application Publication No. 2016/0273040).
  • the 232th target gene is the hsa-miR-22-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • changes in the expression of a gene or its transcription product can serve as a marker for dementia (International Patent No. 2017/186719).
  • the 233rd target gene is the hsa-miR-1237-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 234th target gene is the hsa-miR-1224-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 235th target gene is the hsa-miR-625-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a report that changes in the expression of a gene or a transcription product thereof can be a marker for dementia Patent Document 1.
  • the 236th target gene is the hsa-miR-328-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a report that changes in the expression of a gene or a transcription product thereof can be a marker for dementia Patent Document 7).
  • the 237th target gene is the hsa-miR-122-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a report that changes in the expression of a gene or a transcription product thereof can be a marker for dementia Patent Document 7).
  • the 238th target gene is the hsa-miR-202-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a report that changes in the expression of a gene or a transcription product thereof can be a marker for dementia Patent Document 7).
  • the 239th target gene is the hsa-miR-4781-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • the 240th target gene is an hsa-miR-718 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the target gene 241 is the hsa-miR-342-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. There has been a report that changes in the expression of a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 3).
  • the 242nd target gene is an hsa-miR-26b-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • genes or their transcripts can be markers for dementia (Satoh J., et al., Biomark Insights., 2015, vol. 10, p. 21-). 23).
  • the 243rd target gene is the hsa-miR-140-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a report that changes in the expression of a gene or a transcription product thereof can be a marker for dementia Patent Document 1.
  • the 244th target gene is the hsa-miR-200a-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • changes in the expression of a gene or its transcription product can serve as a marker for dementia (International Patent No. 2017/186719).
  • the 245th target gene is the hsa-miR-378a-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 246th target gene is the hsa-miR-484 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a report that changes in the expression of a gene or a transcription product thereof can be a marker for dementia Patent Document 1.
  • the target gene 247 is the hsa-miR-296-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. There has been a report that changes in the expression of a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 248th target gene is the hsa-miR-205-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a report that changes in the expression of a gene or a transcription product thereof can be a marker for dementia Patent Document 7).
  • the 249th target gene is the hsa-miR-431-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a report that changes in the expression of a gene or a transcription product thereof can be a marker for dementia Patent Document 7).
  • the 250th target gene is the hsa-miR-1471 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 251st target gene is the hsa-miR-1538 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 252nd target gene is the hsa-miR-449b-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 253rd target gene is the hsa-miR-1976 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 254th target gene is the hsa-miR-4268 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 255th target gene is the hsa-miR-4279 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 256th target gene is the hsa-miR-3620-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 257th target gene is the hsa-miR-3944-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 258th target gene is the hsa-miR-3156-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 259th target gene is the hsa-miR-3187-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 260th target gene is the hsa-miR-4485-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the target gene 261 is the hsa-miR-4695-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 262th target gene is the hsa-miR-4697-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 263rd target gene is the hsa-miR-4713-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 264th target gene is the hsa-miR-4723-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 265th target gene is the hsa-miR-371b-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 266th target gene is the hsa-miR-3151-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the target gene 267 is the hsa-miR-3192-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 268th target gene is the hsa-miR-6728-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 269th target gene is the hsa-miR-6736-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 270th target gene is the hsa-miR-6740-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 271st target gene is the hsa-miR-6741-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 272nd target gene is the hsa-miR-6743-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 273rd target gene is the hsa-miR-6747-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 274th target gene is the hsa-miR-6750-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 275th target gene is the hsa-miR-6754-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 276th target gene is the hsa-miR-6759-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 277th target gene is the hsa-miR-6761-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 278th target gene is the hsa-miR-6762-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 279th target gene is the hsa-miR-6769a-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 280th target gene is the hsa-miR-6767-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 281st target gene is the hsa-miR-6778-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 282nd target gene is the hsa-miR-6679-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 283rd target gene is the hsa-miR-6786-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 284th target gene is the hsa-miR-6787-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 285th target gene is the hsa-miR-6792-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 286th target gene is the hsa-miR-6794-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 287th target gene is the hsa-miR-6801-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 288th target gene is the hsa-miR-6802-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 289th target gene is the hsa-miR-6803-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 290th target gene is the hsa-miR-6804-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 291st target gene is the hsa-miR-6810-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 292th target gene is the hsa-miR-6823-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 293rd target gene is the hsa-miR-6825-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 294th target gene is the hsa-miR-6829-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 295th target gene is the hsa-miR-6833-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 296th target gene is the hsa-miR-6834-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 297th target gene is the hsa-miR-6780b-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 298th target gene is the hsa-miR-6845-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 299th target gene is the hsa-miR-6862-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 300th target gene is the hsa-miR-6865-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 301st target gene is the hsa-miR-6870-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 302nd target gene is the hsa-miR-6875-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 303rd target gene is the hsa-miR-6877-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 304th target gene is the hsa-miR-6879-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 305th target gene is the hsa-miR-6882-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 306th target gene is the hsa-miR-6885-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 307th target gene is the hsa-miR-6886-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 308th target gene is the hsa-miR-6687-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 309th target gene is the hsa-miR-6890-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 310th target gene is the hsa-miR-6893-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 311st target gene is the hsa-miR-6894-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 312rd target gene is the hsa-miR-7106-3p gene, their homologs, their transcripts, or their mutants or derivatives. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the target gene 313 is the hsa-miR-7109-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 314th target gene is the hsa-miR-7114-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 315th target gene is the hsa-miR-7155-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 316th target gene is an hsa-miR-7160-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 317th target gene is the hsa-miR-615-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 318th target gene is the hsa-miR-920 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 319th target gene is the hsa-miR-1825 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 320th target gene is the hsa-miR-675-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • 321st target gene is hsa-miR-1910-5p gene, homologues thereof, transcripts thereof, or mutants or derivatives thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 322th target gene is the hsa-miR-2278 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 323rd target gene is the hsa-miR-2682-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 324th target gene is the hsa-miR-3122 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 325th target gene is the hsa-miR-3151-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 326th target gene is the hsa-miR-3175 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 327th target gene is the hsa-miR-4323 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 328th target gene is the hsa-miR-4326 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 329th target gene is the hsa-miR-4284 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 330th target gene is the hsa-miR-3605-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the target gene 331 is the hsa-miR-3622b-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the target gene 332 is the hsa-miR-3646 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 333rd target gene is the hsa-miR-3158-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 334th target gene is the hsa-miR-4722-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 335th target gene is the hsa-miR-4728-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 336th target gene is the hsa-miR-4747-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 337th target gene is the hsa-miR-4436b-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 338th target gene is the hsa-miR-5196-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 339th target gene is the hsa-miR-5589-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 340th target gene is the hsa-miR-345-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 341th target gene is the hsa-miR-642b-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the target gene 342 is the hsa-miR-6716-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 343rd target gene is the hsa-miR-6511b-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 344th target gene is the hsa-miR-208a-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 345th target gene is the hsa-miR-6726-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 346th target gene is the hsa-miR-6744-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 347th target gene is the hsa-miR-6787-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 348th target gene is the hsa-miR-6789-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 349th target gene is the hsa-miR-6797-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 350th target gene is the hsa-miR-6800-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the target gene 351 is the hsa-miR-6806-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 352rd target gene is the hsa-miR-6824-3p gene, their homologues, their transcripts, or their mutants or derivatives. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 353rd target gene is the hsa-miR-6837-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 354th target gene is the hsa-miR-6846-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 355th target gene is the hsa-miR-6858-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 356th target gene is the hsa-miR-6859-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 357th target gene is the hsa-miR-6861-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 358th target gene is the hsa-miR-6880-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 359th target gene is the hsa-miR-7111-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 360th target gene is the hsa-miR-7152-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the target gene 361 is the hsa-miR-642a-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the target gene of 362 is the hsa-miR-657 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the target gene 363 is the hsa-miR-1236-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 364th target gene is the hsa-miR-764 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 365th target gene is the hsa-miR-4314 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 366th target gene is the hsa-miR-3675-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 367th target gene is the hsa-miR-5703 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 368th target gene is the hsa-miR-3191-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 369th target gene is the hsa-miR-6511a-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 370th target gene is the hsa-miR-6809-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 371st target gene is the hsa-miR-6815-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 372rd target gene is the hsa-miR-6857-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 373rd target gene is the hsa-miR-6878-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 374th target gene is the hsa-miR-371a-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 375th target gene is the hsa-miR-766-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 376th target gene is the hsa-miR-1229-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a report that changes in the expression of a gene or a transcription product thereof can be a marker for dementia Patent Document 7).
  • the 377th target gene is the hsa-miR-1306-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 6).
  • the 378th target gene is the hsa-miR-210-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 379th target gene is the hsa-miR-198 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a report that changes in the expression of a gene or a transcription product thereof can be a marker for dementia Patent Document 7).
  • the 380th target gene is the hsa-miR-485-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a report that changes in the expression of a gene or a transcription product thereof can be a marker for dementia Patent Document 7).
  • the 381 target gene is the hsa-miR-668-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 4).
  • the 382rd target gene is the hsa-miR-532-3p gene, their homologues, their transcription products, or their mutants or derivatives. There has been a report that changes in the expression of a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 383rd target gene is the hsa-miR-877-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 384th target gene is the hsa-miR-1238-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a report that changes in the expression of a gene or a transcription product thereof can be a marker for dementia Patent Document 2.
  • the 385th target gene is the hsa-miR-3130-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 386th target gene is the hsa-miR-4298 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 387th target gene is an hsa-miR-4290 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 388th target gene is the hsa-miR-3943 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 389th target gene is the hsa-miR-346 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 3).
  • the 390th target gene is the hsa-miR-767-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof.
  • a gene or a transcription product thereof can serve as a marker for dementia (Patent Document 5).
  • the 391st target gene is the hsa-miR-6765-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 392rd target gene is the hsa-miR-6784-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 393rd target gene is the hsa-miR-6778-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 394th target gene is the hsa-miR-6875-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 395th target gene is the hsa-miR-4534 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 396th target gene is the hsa-miR-4721 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 397th target gene is the hsa-miR-6756-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 398th target gene is the hsa-miR-615-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 399th target gene is the hsa-miR-6727-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 400th target gene is the hsa-miR-6687-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 401st target gene is the hsa-miR-8063 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 402nd target gene is the hsa-miR-6880-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 403rd target gene is the hsa-miR-6805-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 404th target gene is the hsa-miR-4726-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 405th target gene is the hsa-miR-4710 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 406th target gene is the hsa-miR-7111-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 407th target gene is the hsa-miR-3619-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 408th target gene is the hsa-miR-6695-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 409th target gene is the hsa-miR-1254 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 410th target gene is the hsa-miR-1233-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 411st target gene is the hsa-miR-6836-3p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 412 target gene is the hsa-miR-6769a-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 413th target gene is the hsa-miR-4532 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 414th target gene is an hsa-miR-365a-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 415th target gene is the hsa-miR-1231 gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.
  • the 416th target gene is the hsa-miR-1228-5p gene, a homologue thereof, a transcription product thereof, or a mutant or derivative thereof. So far, there is no report that changes in the expression of genes or their transcripts can serve as markers for dementia.

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EP19754972.8A EP3754019B1 (en) 2018-02-13 2019-02-12 Use of a kit or device and method for detecting dementia
EP25205653.6A EP4697021A2 (en) 2018-02-13 2019-02-12 Kit or device and method for detecting dementia
CA3091211A CA3091211A1 (en) 2018-02-13 2019-02-12 Kit or device and method for detecting dementia
EP23216032.5A EP4328587A3 (en) 2018-02-13 2019-02-12 Use of a kit or device and method for detecting dementia
CN201980013178.0A CN111742060A (zh) 2018-02-13 2019-02-12 用于痴呆的检测的试剂盒或器件和方法
JP2020500479A JP7414237B2 (ja) 2018-02-13 2019-02-12 認知症の検出のためのキット又はデバイス及び方法
US16/969,328 US12529104B2 (en) 2018-02-13 2019-02-12 Kit or device and method for detecting dementia
KR1020207022584A KR20200120627A (ko) 2018-02-13 2019-02-12 인지증 검출을 위한 키트 또는 디바이스 및 방법
EP24217565.1A EP4498086A3 (en) 2018-02-13 2019-02-12 Kit or device and method for detecting dementia
JP2023214501A JP2024037978A (ja) 2018-02-13 2023-12-20 認知症の検出のためのキット又はデバイス及び方法
JP2025152479A JP2025186374A (ja) 2018-02-13 2025-09-12 認知症の検出のためのキット又はデバイス及び方法
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US12522827B2 (en) 2016-03-02 2026-01-13 The Board Of Trustees Of The Leland Stanford Junior University Pan-genotypic agents against influenza virus and methods of using the same
CN110511994A (zh) * 2019-09-09 2019-11-29 中南大学湘雅二医院 miRNA-4769-3p及其同源物的应用
CN110511994B (zh) * 2019-09-09 2023-05-26 中南大学湘雅二医院 miRNA-4769-3p及其同源物的应用
EP4464779A3 (en) * 2020-02-14 2025-06-25 The Board of Trustees of the Leland Stanford Junior University Pan-genotypic agents against respiratory viruses and methods of using the same
WO2021201092A1 (ja) 2020-03-31 2021-10-07 東レ株式会社 海馬萎縮を検出するためのキット又はデバイス及び方法
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CN115485378A (zh) * 2020-03-31 2022-12-16 东丽株式会社 用于检测海马萎缩的试剂盒或器件以及方法
WO2021251504A1 (ja) * 2020-06-12 2021-12-16 国際スペースメディカル株式会社 血中ｒｎａを利用したｃｏｖｉｄ－１９重症化予測方法
JP2024507897A (ja) * 2021-02-24 2024-02-21 コリア リサーチ インスティチュート オブ バイオサイエンス アンド バイオテクノロジー 体液検査基盤の退行性脳疾患の診断およびモニタリング技術
US12618063B2 (en) 2024-07-16 2026-05-05 The Board Of Trustees Of The Leland Stanford Junior University Pan-genotypic agents against influenza virus and methods of using the same

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