WO2017215680A3 - 氯普噻吨的药物组合物及对脑缺血再灌注损伤的保护作用 - Google Patents
氯普噻吨的药物组合物及对脑缺血再灌注损伤的保护作用 Download PDFInfo
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- WO2017215680A3 WO2017215680A3 PCT/CN2017/097017 CN2017097017W WO2017215680A3 WO 2017215680 A3 WO2017215680 A3 WO 2017215680A3 CN 2017097017 W CN2017097017 W CN 2017097017W WO 2017215680 A3 WO2017215680 A3 WO 2017215680A3
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- Prior art keywords
- chlorprothixene
- cerebral ischemia
- ischemia reperfusion
- reperfusion injuries
- pharmaceutical composition
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/342—Adenophora
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
本发明公开了氯普噻吨的药物组合物及对脑缺血再灌注损伤的保护作用,本发明提供的氯普噻吨的药物组合物中含有氯普噻吨和一种从南沙参中分离得到的结构新颖的天然产物化合物(Ⅰ),氯普噻吨和该天然产物单独作用时,可以降低脑缺血再灌注损伤;二者联合作用时,对脑缺血再灌注损伤的防治作用更优,可以开发成防治脑缺血再灌注损伤的药物,与现有技术相比具有突出的实质性特点和显著的进步。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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CN201610408807.8A CN106083800A (zh) | 2016-06-13 | 2016-06-13 | 氯普噻吨的药物组合物及对脑缺血再灌注损伤的保护作用 |
CN201610408807.8 | 2016-06-13 |
Publications (2)
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WO2017215680A2 WO2017215680A2 (zh) | 2017-12-21 |
WO2017215680A3 true WO2017215680A3 (zh) | 2018-02-15 |
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PCT/CN2017/097017 WO2017215680A2 (zh) | 2016-06-13 | 2017-08-11 | 氯普噻吨的药物组合物及对脑缺血再灌注损伤的保护作用 |
Country Status (2)
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CN (1) | CN106083800A (zh) |
WO (1) | WO2017215680A2 (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105777849A (zh) * | 2016-04-23 | 2016-07-20 | 何淑琼 | 一种酒石酸布托啡诺的药物组合物及其医药用途 |
CN106083800A (zh) * | 2016-06-13 | 2016-11-09 | 崔坤峰 | 氯普噻吨的药物组合物及对脑缺血再灌注损伤的保护作用 |
CN106045835A (zh) * | 2016-06-23 | 2016-10-26 | 崔坤峰 | 盐酸苄丝肼的药物组合物及其降血糖的医药用途 |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102802622A (zh) * | 2009-05-14 | 2012-11-28 | 艾雪米克斯公司 | 用于治疗缺血和缺血再灌注损伤的组合物和方法 |
CN103191103A (zh) * | 2013-04-15 | 2013-07-10 | 中南大学 | 乙醛脱氢酶激活物alda-1的合成方法及其用途 |
CN103396368A (zh) * | 2013-07-29 | 2013-11-20 | 中国人民解放军第四军医大学 | 氮氧自由基在治疗缺血再灌注损伤中的应用 |
CN105017276A (zh) * | 2015-08-19 | 2015-11-04 | 庄立 | 一种用于治疗胰腺癌的五元环氧结构化合物 |
CN105061413A (zh) * | 2015-09-06 | 2015-11-18 | 叶澄 | 一种新的柠檬苦素化合物,含其的药物组合物及其制备方法和应用 |
CN105061197A (zh) * | 2015-08-28 | 2015-11-18 | 林天样 | 一种新的三萜化合物及其制备方法和医药用途 |
CN105111275A (zh) * | 2015-09-16 | 2015-12-02 | 张利文 | 一种新的三萜化合物及其制备方法和医药用途 |
CN105777849A (zh) * | 2016-04-23 | 2016-07-20 | 何淑琼 | 一种酒石酸布托啡诺的药物组合物及其医药用途 |
CN105820144A (zh) * | 2016-04-23 | 2016-08-03 | 吴珺 | 一种头孢地尼的药物组合物及其医药用途 |
CN105837595A (zh) * | 2016-04-23 | 2016-08-10 | 徐月苗 | 阿替洛尔的药物组合物及其在生物医药中的应用 |
CN106083800A (zh) * | 2016-06-13 | 2016-11-09 | 崔坤峰 | 氯普噻吨的药物组合物及对脑缺血再灌注损伤的保护作用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105693743A (zh) * | 2016-04-23 | 2016-06-22 | 吴国春 | 氯碘羟喹的药物组合物及其在生物医药中的应用 |
CN105796560A (zh) * | 2016-04-23 | 2016-07-27 | 徐挺 | 环丙沙星的药物组合物及其在生物医药中的应用 |
CN105777516A (zh) * | 2016-04-23 | 2016-07-20 | 何淑琼 | 盐酸安非他酮的药物组合物及其在生物医药中的应用 |
CN106045944A (zh) * | 2016-05-15 | 2016-10-26 | 刘雨 | 拉米夫定的药物组合物及其在生物医药中的应用 |
CN105949150A (zh) * | 2016-05-19 | 2016-09-21 | 蒋灵锟 | 异环磷酰胺的药物组合物及其在生物医药中的应用 |
CN105949159A (zh) * | 2016-05-19 | 2016-09-21 | 江苏神龙药业有限公司 | 盐酸普拉克索的药物组合物及其治疗偏头痛的用途 |
CN105777842A (zh) * | 2016-05-28 | 2016-07-20 | 黄芳 | 哈西奈德的药物组合物及其在生物医药中的应用 |
CN106046103A (zh) * | 2016-05-28 | 2016-10-26 | 刘慎权 | 异烟肼的药物组合物及其在生物医药中的应用 |
CN106083876A (zh) * | 2016-05-31 | 2016-11-09 | 黄芳 | 盐酸阿糖胞苷的药物组合物及其在生物医药中的应用 |
-
2016
- 2016-06-13 CN CN201610408807.8A patent/CN106083800A/zh active Pending
-
2017
- 2017-08-11 WO PCT/CN2017/097017 patent/WO2017215680A2/zh active Application Filing
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102802622A (zh) * | 2009-05-14 | 2012-11-28 | 艾雪米克斯公司 | 用于治疗缺血和缺血再灌注损伤的组合物和方法 |
CN103191103A (zh) * | 2013-04-15 | 2013-07-10 | 中南大学 | 乙醛脱氢酶激活物alda-1的合成方法及其用途 |
CN103396368A (zh) * | 2013-07-29 | 2013-11-20 | 中国人民解放军第四军医大学 | 氮氧自由基在治疗缺血再灌注损伤中的应用 |
CN105017276A (zh) * | 2015-08-19 | 2015-11-04 | 庄立 | 一种用于治疗胰腺癌的五元环氧结构化合物 |
CN105061197A (zh) * | 2015-08-28 | 2015-11-18 | 林天样 | 一种新的三萜化合物及其制备方法和医药用途 |
CN105061413A (zh) * | 2015-09-06 | 2015-11-18 | 叶澄 | 一种新的柠檬苦素化合物,含其的药物组合物及其制备方法和应用 |
CN105111275A (zh) * | 2015-09-16 | 2015-12-02 | 张利文 | 一种新的三萜化合物及其制备方法和医药用途 |
CN105777849A (zh) * | 2016-04-23 | 2016-07-20 | 何淑琼 | 一种酒石酸布托啡诺的药物组合物及其医药用途 |
CN105820144A (zh) * | 2016-04-23 | 2016-08-03 | 吴珺 | 一种头孢地尼的药物组合物及其医药用途 |
CN105837595A (zh) * | 2016-04-23 | 2016-08-10 | 徐月苗 | 阿替洛尔的药物组合物及其在生物医药中的应用 |
CN106083800A (zh) * | 2016-06-13 | 2016-11-09 | 崔坤峰 | 氯普噻吨的药物组合物及对脑缺血再灌注损伤的保护作用 |
Non-Patent Citations (2)
Title |
---|
PANG XIAOBIN ET AL.: "Protective effect of mailuoning injection on cerebral Ischemia/Reperfusion Injury in Rats and its mechanism", CHINA JOURNAL OF CHINESE MATERIA MEDICA, 28 February 2014 (2014-02-28), pages 721 - 725 * |
SURUP, FRANK ET AL.: "Sporothriolide derivatives as chemotaxonomic markers for Hypoxylon monticulosum", MYCOLOGY, vol. 5, no. 3, 3 July 2014 (2014-07-03) - 31 December 2014 (2014-12-31), pages 110 - 119, XP055600960, ISSN: 2150-1203, DOI: 10.1080/21501203.2014.929600 * |
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CN106083800A (zh) | 2016-11-09 |
WO2017215680A2 (zh) | 2017-12-21 |
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