MX2019001771A - Composición farmacéutica sólida que comprende el sofosbuvir amorfo. - Google Patents
Composición farmacéutica sólida que comprende el sofosbuvir amorfo.Info
- Publication number
- MX2019001771A MX2019001771A MX2019001771A MX2019001771A MX2019001771A MX 2019001771 A MX2019001771 A MX 2019001771A MX 2019001771 A MX2019001771 A MX 2019001771A MX 2019001771 A MX2019001771 A MX 2019001771A MX 2019001771 A MX2019001771 A MX 2019001771A
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutical composition
- solid pharmaceutical
- sofosbuvir
- amorphous sofosbuvir
- solid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
Abstract
Se proporciona una composición farmacéutica sólida, la cual comprende el sofosbuvir, uno o más excipientes farmacéuticamente aceptables y, de una forma opcional, por lo menos un compuesto de matriz farmacéuticamente aceptable, en donde por lo menos el 99 por ciento en peso del sofosbuvir comprendido en la composición farmacéutica sólida está presente en una forma amorfa. La forma amorfa de sofosbuvir es estable en la composición farmacéutica sólica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16184053 | 2016-08-12 | ||
PCT/EP2017/070215 WO2018029262A1 (en) | 2016-08-12 | 2017-08-09 | Solid pharmaceutical composition comprising amorphous sofosbuvir |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019001771A true MX2019001771A (es) | 2019-11-18 |
Family
ID=56684527
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019001771A MX2019001771A (es) | 2016-08-12 | 2017-08-09 | Composición farmacéutica sólida que comprende el sofosbuvir amorfo. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20190167706A1 (es) |
EP (1) | EP3496705A1 (es) |
JP (1) | JP2019530645A (es) |
KR (1) | KR20190038881A (es) |
CN (1) | CN109862884A (es) |
AU (1) | AU2017309302A1 (es) |
BR (1) | BR112019002729A2 (es) |
CA (1) | CA3033319A1 (es) |
MX (1) | MX2019001771A (es) |
RU (1) | RU2019106294A (es) |
WO (1) | WO2018029262A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110214711A (zh) * | 2019-06-28 | 2019-09-10 | 昱庆塑胶五金制品(惠州)有限公司 | 智能宠物喂食器 |
CN111467363A (zh) * | 2020-04-07 | 2020-07-31 | 中国科学院深圳先进技术研究院 | 索非布韦在制备预防和治疗冠状病毒的药物中的应用 |
CN111773192A (zh) * | 2020-08-18 | 2020-10-16 | 福建广生堂药业股份有限公司 | 一种索磷布韦片剂及其制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI576352B (zh) | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
SG184323A1 (en) | 2010-03-31 | 2012-11-29 | Gilead Pharmasett Llc | Stereoselective synthesis of phosphorus containing actives |
EP2907505A3 (en) | 2011-12-29 | 2015-12-30 | Abbvie Inc. | Solid compositions comprising an HCV inhibitor |
WO2015132321A1 (en) * | 2014-03-05 | 2015-09-11 | Galenicum Health S.L. | Stable pharmaceutical compositions of sofosbuvir |
CA2943574A1 (en) * | 2014-04-03 | 2015-10-08 | Sandoz Ag | Solid composition comprising amorphous sofosbuvir |
WO2016038542A2 (en) * | 2014-09-10 | 2016-03-17 | Mylan Laboratories Limited | Polymorphic forms of sofosbuvir |
CN104586802B (zh) * | 2015-02-02 | 2018-01-16 | 长春海悦药业股份有限公司 | 一种含有索菲布韦的药物组合物 |
-
2017
- 2017-08-09 CA CA3033319A patent/CA3033319A1/en not_active Abandoned
- 2017-08-09 CN CN201780063084.5A patent/CN109862884A/zh not_active Withdrawn
- 2017-08-09 AU AU2017309302A patent/AU2017309302A1/en not_active Abandoned
- 2017-08-09 RU RU2019106294A patent/RU2019106294A/ru not_active Application Discontinuation
- 2017-08-09 BR BR112019002729-7A patent/BR112019002729A2/pt not_active Application Discontinuation
- 2017-08-09 US US16/324,674 patent/US20190167706A1/en not_active Abandoned
- 2017-08-09 WO PCT/EP2017/070215 patent/WO2018029262A1/en unknown
- 2017-08-09 EP EP17749723.7A patent/EP3496705A1/en not_active Withdrawn
- 2017-08-09 KR KR1020197006578A patent/KR20190038881A/ko unknown
- 2017-08-09 MX MX2019001771A patent/MX2019001771A/es unknown
- 2017-08-09 JP JP2019507117A patent/JP2019530645A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3033319A1 (en) | 2018-02-15 |
BR112019002729A2 (pt) | 2019-05-14 |
WO2018029262A1 (en) | 2018-02-15 |
JP2019530645A (ja) | 2019-10-24 |
EP3496705A1 (en) | 2019-06-19 |
CN109862884A (zh) | 2019-06-07 |
AU2017309302A1 (en) | 2019-02-21 |
US20190167706A1 (en) | 2019-06-06 |
KR20190038881A (ko) | 2019-04-09 |
RU2019106294A (ru) | 2020-09-21 |
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