WO2017220042A3 - 氨力农的药物组合物及其在高血压治疗中的应用 - Google Patents

氨力农的药物组合物及其在高血压治疗中的应用 Download PDF

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Publication number
WO2017220042A3
WO2017220042A3 PCT/CN2017/097767 CN2017097767W WO2017220042A3 WO 2017220042 A3 WO2017220042 A3 WO 2017220042A3 CN 2017097767 W CN2017097767 W CN 2017097767W WO 2017220042 A3 WO2017220042 A3 WO 2017220042A3
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WO
WIPO (PCT)
Prior art keywords
amrinone
pharmaceutical composition
application
hypertension
treatment
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PCT/CN2017/097767
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English (en)
French (fr)
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WO2017220042A2 (zh
Inventor
崔坤峰
Original Assignee
赵吉永
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Publication of WO2017220042A2 publication Critical patent/WO2017220042A2/zh
Publication of WO2017220042A3 publication Critical patent/WO2017220042A3/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明公开了氨力农的药物组合物及其在高血压治疗中的应用，本发明提供的氨力农的药物组合物中含有氨力农和一种从射干的干燥根茎中分离得到的结构新颖的天然产物化合物(Ⅰ)，氨力农和该天然产物化合物(Ⅰ)单独作用时，对肾血管性高血压具有治疗作用；二者联合作用时，对肾血管性高血压的治疗效果进一步提高，可以开发成治疗肾血管性高血压的药物，与现有技术相比具有突出的实质性特点和显著的进步。
PCT/CN2017/097767 2016-06-23 2017-08-17 氨力农的药物组合物及其在高血压治疗中的应用 WO2017220042A2 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610459480.7 2016-06-23
CN201610459480.7A CN106117166A (zh) 2016-06-23 2016-06-23 氨力农的药物组合物及其在高血压治疗中的应用

Publications (2)

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WO2017220042A2 WO2017220042A2 (zh) 2017-12-28
WO2017220042A3 true WO2017220042A3 (zh) 2018-02-15

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PCT/CN2017/097767 WO2017220042A2 (zh) 2016-06-23 2017-08-17 氨力农的药物组合物及其在高血压治疗中的应用

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CN (1) CN106117166A (zh)
WO (1) WO2017220042A2 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105777683A (zh) * 2016-04-08 2016-07-20 庄立 双环醇的药物组合物及其医药用途
CN106117166A (zh) * 2016-06-23 2016-11-16 崔坤峰 氨力农的药物组合物及其在高血压治疗中的应用
CN106045835A (zh) * 2016-06-23 2016-10-26 崔坤峰 盐酸苄丝肼的药物组合物及其降血糖的医药用途
CN106279344A (zh) * 2016-08-14 2017-01-04 吴芊葭 一种从防风中分离的天然化合物及其制备方法、医药应用
CN110283061A (zh) * 2019-07-22 2019-09-27 河北省农林科学院经济作物研究所 用于降血压的新型化合物及其提取方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101926800A (zh) * 2010-07-23 2010-12-29 陈益智 含有氨力农的药用组合物及其制备方法和应用
CN104557690A (zh) * 2013-10-23 2015-04-29 丹阳恒安化学科技研究所有限公司 一种制备氨力农中间体的方法
CN106117166A (zh) * 2016-06-23 2016-11-16 崔坤峰 氨力农的药物组合物及其在高血压治疗中的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105777683A (zh) * 2016-04-08 2016-07-20 庄立 双环醇的药物组合物及其医药用途
CN105924421A (zh) * 2016-04-23 2016-09-07 何华琼 盐酸氨溴索的药物组合物及其在生物医药中的应用
CN106045943A (zh) * 2016-05-28 2016-10-26 黄芳 一种格隆溴铵的药物组合物及其医药用途
CN106083981A (zh) * 2016-06-07 2016-11-09 刘慎权 一种硫酸异帕米星的药物组合物及其医药用途
CN106074561A (zh) * 2016-06-13 2016-11-09 崔坤峰 羧甲司坦的药物组合物及其对白血病的治疗作用
CN106083988A (zh) * 2016-06-22 2016-11-09 陈露 一种二巯丁二酸的药物组合物及其医药用途
CN106109461A (zh) * 2016-06-23 2016-11-16 崔坤峰 苯扎贝特的药物组合物及其在类风湿性关节炎中的应用
CN106146528A (zh) * 2016-07-15 2016-11-23 郑巧丹 一种新的二萜生物碱类化合物及其制备方法和医药用途
CN106188087A (zh) * 2016-07-21 2016-12-07 林翔 一种盐酸纳洛酮的药物组合物及其医药用途
CN106309451A (zh) * 2016-08-14 2017-01-11 吴芊葭 一种头孢呋辛酯的药物组合物及其医药用途
CN106397369A (zh) * 2016-09-09 2017-02-15 中国科学院西北高原生物研究所 一种新的半日花烷型二萜化合物及其制备方法和应用、药物组合物及其应用
CN106496205A (zh) * 2016-09-12 2017-03-15 南通市科通科技信息咨询有限公司 一种左氧氟沙星的药物组合物及其医药用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101926800A (zh) * 2010-07-23 2010-12-29 陈益智 含有氨力农的药用组合物及其制备方法和应用
CN104557690A (zh) * 2013-10-23 2015-04-29 丹阳恒安化学科技研究所有限公司 一种制备氨力农中间体的方法
CN106117166A (zh) * 2016-06-23 2016-11-16 崔坤峰 氨力农的药物组合物及其在高血压治疗中的应用

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WO2017220042A2 (zh) 2017-12-28
CN106117166A (zh) 2016-11-16

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