WO2017220044A3 - 联苯苄唑的药物组合物及其保肝作用 - Google Patents

联苯苄唑的药物组合物及其保肝作用 Download PDF

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Publication number
WO2017220044A3
WO2017220044A3 PCT/CN2017/097769 CN2017097769W WO2017220044A3 WO 2017220044 A3 WO2017220044 A3 WO 2017220044A3 CN 2017097769 W CN2017097769 W CN 2017097769W WO 2017220044 A3 WO2017220044 A3 WO 2017220044A3
Authority
WO
WIPO (PCT)
Prior art keywords
bifonazole
liver
pharmaceutical composition
protecting effect
compound
Prior art date
Application number
PCT/CN2017/097769
Other languages
English (en)
French (fr)
Other versions
WO2017220044A2 (zh
Inventor
崔坤峰
Original Assignee
赵吉永
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 赵吉永 filed Critical 赵吉永
Publication of WO2017220044A2 publication Critical patent/WO2017220044A2/zh
Publication of WO2017220044A3 publication Critical patent/WO2017220044A3/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966—Fritillaria, e.g. checker lily or mission bells

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明公开了联苯苄唑的药物组合物及其保肝作用，本发明提供的联苯苄唑的药物组合物中含有联苯苄唑和一种从浙贝母的干燥鳞茎中分离得到的结构新颖的天然产物化合物(Ⅰ)，联苯苄唑、化合物(Ⅰ)可以提高小鼠肝组织中GSH含量，降低MDA含量，抑制TG的积累，具有一定的保肝作用；联苯苄唑和化合物(Ⅰ)联合使用时，治疗效果更好，可开发成保肝药物，与现有技术相比具有突出的实质性特点和显著的进步。
PCT/CN2017/097769 2016-06-23 2017-08-17 联苯苄唑的药物组合物及其保肝作用 WO2017220044A2 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610463340.7A CN106083875A (zh) 2016-06-23 2016-06-23 联苯苄唑的药物组合物及其保肝作用
CN201610463340.7 2016-06-23

Publications (2)

Publication Number Publication Date
WO2017220044A2 WO2017220044A2 (zh) 2017-12-28
WO2017220044A3 true WO2017220044A3 (zh) 2018-02-15

Family

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PCT/CN2017/097769 WO2017220044A2 (zh) 2016-06-23 2017-08-17 联苯苄唑的药物组合物及其保肝作用

Country Status (2)

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CN (1) CN106083875A (zh)
WO (1) WO2017220044A2 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106083875A (zh) * 2016-06-23 2016-11-09 崔坤峰 联苯苄唑的药物组合物及其保肝作用
CN106045835A (zh) * 2016-06-23 2016-10-26 崔坤峰 盐酸苄丝肼的药物组合物及其降血糖的医药用途

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105622563A (zh) * 2016-04-08 2016-06-01 庄立 盐酸溴己新的药物组合物及其医药用途
CN105693668A (zh) * 2016-04-23 2016-06-22 贺玉皓 一种氯法齐明的药物组合物及其医药用途
CN105801540A (zh) * 2016-04-23 2016-07-27 黄亦琼 一种盐酸卡替洛尔的药物组合物及其医药用途
CN105796560A (zh) * 2016-04-23 2016-07-27 徐挺 环丙沙星的药物组合物及其在生物医药中的应用
CN105837654A (zh) * 2016-04-18 2016-08-10 镇江高海生物药业有限公司 一种盐酸强力霉素的药物组合物及其生物医药用途
CN105884715A (zh) * 2016-04-23 2016-08-24 陈斌 一种苄达赖氨酸的药物组合物及其医药用途
CN106083875A (zh) * 2016-06-23 2016-11-09 崔坤峰 联苯苄唑的药物组合物及其保肝作用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105709053A (zh) * 2016-04-01 2016-06-29 胡文杰 一种具有保肝作用的中药复方及其制备方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105622563A (zh) * 2016-04-08 2016-06-01 庄立 盐酸溴己新的药物组合物及其医药用途
CN105837654A (zh) * 2016-04-18 2016-08-10 镇江高海生物药业有限公司 一种盐酸强力霉素的药物组合物及其生物医药用途
CN105693668A (zh) * 2016-04-23 2016-06-22 贺玉皓 一种氯法齐明的药物组合物及其医药用途
CN105801540A (zh) * 2016-04-23 2016-07-27 黄亦琼 一种盐酸卡替洛尔的药物组合物及其医药用途
CN105796560A (zh) * 2016-04-23 2016-07-27 徐挺 环丙沙星的药物组合物及其在生物医药中的应用
CN105884715A (zh) * 2016-04-23 2016-08-24 陈斌 一种苄达赖氨酸的药物组合物及其医药用途
CN106083875A (zh) * 2016-06-23 2016-11-09 崔坤峰 联苯苄唑的药物组合物及其保肝作用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
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QUANG, D.N. ET AL.: "Cohaerins C-F, Four Azaphilones from the Xylariaceous Fungus Annulohypoxylon Cohaerens", TETRAHEDRON, vol. 62, 11 May 2006 (2006-05-11), pages 6349 - 6354, XP025002152, ISSN: 0040-4020 *
SURUP, F. ET AL.: "Cohaerins G-K, Azaphilone Pigments from Annulohypoxylon Cohaerens and Absolute Stereochemistry of Cohaerins C-K", PHYTOCHEMISTRY, vol. 95, 19 August 2013 (2013-08-19), pages 252 - 258, XP055464624, ISSN: 0031-9422 *

Also Published As

Publication number Publication date
CN106083875A (zh) 2016-11-09
WO2017220044A2 (zh) 2017-12-28

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