WO2016063815A1 - 温度制御剤ならびにそれを用いた発熱組成物、包材及び温熱材 - Google Patents
温度制御剤ならびにそれを用いた発熱組成物、包材及び温熱材 Download PDFInfo
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- WO2016063815A1 WO2016063815A1 PCT/JP2015/079374 JP2015079374W WO2016063815A1 WO 2016063815 A1 WO2016063815 A1 WO 2016063815A1 JP 2015079374 W JP2015079374 W JP 2015079374W WO 2016063815 A1 WO2016063815 A1 WO 2016063815A1
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- temperature control
- thermal material
- temperature
- control agent
- exothermic composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F7/03—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F7/03—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction
- A61F7/032—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction using oxygen from the air, e.g. pocket-stoves
- A61F7/034—Flameless
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
- A61H39/06—Devices for heating or cooling such points within cell-life limits
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K5/00—Heat-transfer, heat-exchange or heat-storage materials, e.g. refrigerants; Materials for the production of heat or cold by chemical reactions other than by combustion
- C09K5/16—Materials undergoing chemical reactions when used
- C09K5/18—Non-reversible chemical reactions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0098—Heating or cooling appliances for medical or therapeutic treatment of the human body ways of manufacturing heating or cooling devices for therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0203—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor
- A61F2007/0206—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor containing organic solids or fibres
- A61F2007/0207—Plants, dried plants, seeds or fruits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0225—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof
- A61F2007/0226—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof adhesive, self-sticking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0225—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof
- A61F2007/0228—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof with belt or strap, e.g. with buckle
- A61F2007/023—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof with belt or strap, e.g. with buckle with pockets for receiving packs or pouches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0244—Compresses or poultices for effecting heating or cooling with layers
- A61F2007/0257—Compresses or poultices for effecting heating or cooling with layers with a fluid impermeable layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0244—Compresses or poultices for effecting heating or cooling with layers
- A61F2007/0258—Compresses or poultices for effecting heating or cooling with layers with a fluid permeable layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F7/03—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction
- A61F7/032—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction using oxygen from the air, e.g. pocket-stoves
- A61F7/034—Flameless
- A61F2007/036—Fuels
- A61F2007/038—Carbon or charcoal, e.g. active
Definitions
- the present invention relates to a temperature control agent used in the production of a heating material such as a chemical warmer (heater) and a heating pad structure, which generates heat by reacting with oxygen, a heating composition and a packaging material using the same, and the use thereof It relates to the thermal material.
- a heating material such as a chemical warmer (heater) and a heating pad structure, which generates heat by reacting with oxygen, a heating composition and a packaging material using the same, and the use thereof It relates to the thermal material.
- Heating materials that use exothermic compositions that generate heat in contact with oxygen or air are used as medical devices such as hot compresses and meridian stimulating heating devices to reduce pain due to heat, or to warmers such as warmers for cold protection. In general, it is widely used as daily necessities such as heating equipment.
- the exothermic composition used for such a thermal material most commonly contains a metal powder such as iron powder, a salt such as salt, water, a water retention agent such as activated carbon, etc. as a component, and the metal is oxygen. Generates heat due to the heat of oxidation generated by reaction Therefore, conventionally, by controlling the inflow of oxygen by the air permeability, moisture permeability, material, etc. of the breathable packaging material of the bag body containing the exothermic composition, particularly the breathable (porous) film, The exothermic characteristics have been adjusted so as to be within a desired range according to the purpose.
- the maximum temperature, rise time, and duration of heat generation can be adjusted by such a method, and products are designed so that they are optimal when used under certain conditions.
- strictly managing the performance of the packaging material is a burden in terms of manufacturing cost.
- no matter how high-performance air-permeable packaging material is used if the airflow in actual use is not as designed due to the usage mode or pinholes of the bag, the originally planned performance may not be demonstrated. May cause safety problems.
- a general disposable body warmer may be affected by changes in the ambient temperature or the amount of air supplied to the body warmer due to movement indoors or outdoors, attachment / detachment of a coat, etc., and the heat generation temperature may fluctuate.
- a warmer is forbidden to use at bedtime. This is because heat dissipation is reduced by covering with a futon or the like, and as a result of the temperature rise, there is a risk of low-temperature burns.
- the disposable body warmer for shoes is scheduled to be used in an environment where the inflow of air is restricted, and is manufactured using a packaging material having a relatively high air permeability.
- the amount of air supplied for each type of shoe is different, so that temperature variation may occur or the temperature may rise rapidly when the shoe is removed.
- a transdermal medical warm compress that combines a heating element and a drug is said to have the advantage of increasing the effect and reducing the amount of drug due to the efficiency of transdermal absorption by heat.
- a heating element that can be used for a short time as an alternative to firewood without fire.
- disposable warmer technology that lacks temperature stability due to its high temperature zone has a high risk and is not widespread.
- the present invention realizes temperature control of a thermal material easily and at a lower cost, which can be used in place of or in combination with the conventional temperature control by controlling the supply amount of oxygen or air with a breathable film or the like. It is an object to provide means and a thermal material using the means. In addition, the present invention provides a more advanced temperature control means that can be used for a medical thermal material, and provides an improved medical thermal material that is safer and more effective. With the goal.
- a temperature control agent for controlling an exothermic temperature of a thermal material containing an exothermic composition that generates heat by reacting with oxygen having a melting point of 35 ° C. or higher and 65 ° C. or lower and water solubility at 20 ° C.
- the temperature control agent contains one or more compounds selected from the group consisting of a higher ⁇ -olefin polymer, paraffin wax, myristyl myristate, polyester polyol, polyoxyethylene fatty acid diester, [1] The temperature control agent as described; [3] An exothermic composition containing metal powder, salts, water and activated carbon, which generates heat upon reaction with oxygen, and further contains the temperature control agent according to the above [1] or [2] Exothermic composition; [4] A thermal material in which at least a part in which the exothermic composition according to [3] is contained includes a breathable bag; [5] The thermal material according to [4], further including means for fixing the bag body to the object to be heated; [6] The thermal material according to [4] or [5], wherein at least the bag body is accommodated in an airtight outer bag that substantially blocks oxygen; [7] The thermal material according to any one
- a simple, low-cost and reliable temperature control means that can be used in place of or in addition to temperature control by a breathable film is provided, and safety with higher temperature stability is provided.
- High thermal material can be realized.
- the present invention provides a thermal material that has a low risk of low-temperature burn even when used, for example, during sleep.
- -Thermal material that can be used safely at bedtime with reduced risk of low-temperature burns due to the covering of the futon; -A safe disposable warmer for shoes that generates stable heat regardless of the type of shoes and does not cause a sudden rise in temperature when the shoes are removed; -Highly stable and effective transdermal medical hot compress with high temperature stability; -Thermal materials such as rice cakes and other warming devices that can be used safely by controlling the maximum temperature even in high temperature zones will be provided.
- FIG. 1 is a view showing a heat generation pattern of a thermal material filled with the heat generation compositions of Examples 1 to 8.
- FIG. 2 is a view showing a heat generation pattern of the thermal material filled with the heat generation compositions of Examples 9 to 16.
- FIG. 3 is a diagram showing a heat generation pattern of a thermal material filled with the heat generation compositions of Comparative Examples 1 to 4.
- FIG. 4 is a diagram showing a heat generation pattern of a thermal material using the breathable packaging material of Examples 17 and 18.
- FIG. 5 is a diagram showing a heat generation pattern of the thermal material filled with the heat generation composition of Example 3 under a condition that mimics the state of use while sleeping (after 3 hours from the start of heat generation).
- FIG. 1 is a view showing a heat generation pattern of a thermal material filled with the heat generation compositions of Examples 1 to 8.
- FIG. 2 is a view showing a heat generation pattern of the thermal material filled with the heat generation compositions of Examples 9 to 16.
- FIG. 3 is a diagram showing a heat
- FIG. 6 is a diagram showing an example of the structure of the meridian stimulation heating device (stool) according to the present invention.
- Panels A and B are cross-sectional views of the tool
- panel C is a perspective view of the exothermic composition tablet (1)
- panel D is a perspective view of the exothermic composition tablet (1) in the container body (2)
- Panel E is a perspective view showing the container body (2) containing the exothermic composition tablet (1) together with the top material (3), the pedestal (4), and the adhesive layer (adhesive tape) (5) added thereto. .
- the pedestal may not exist.
- exothermic composition tablet (1) in FIG. 6 is typically shown in the form before adding salt water (or water) (before swelling).
- FIG. 7 is a diagram showing the result of measuring the presence or absence of the influence of the plate temperature on the maximum temperature of the fixture at a room temperature of 20 ° C.
- Panel A used the fixture used in Example 21 (1208-3 formulation), Panel B used in Example 22 (1201-1 formulation), and Panels C and D used Example 19 (0123 formulation).
- FIG. 8 is a diagram showing the results of measuring the influence of room temperature on the maximum temperature of the fixture at room temperature of 15 ° C., 20 ° C., and 25 ° C.
- Panel A used the fixture used in Example 22, and Panels B and C used Example 19.
- FIG. 9 is a diagram showing the results of examining the influence of the nell coating on the maximum temperature of the jig by changing the content of the temperature control agent of the present invention. It is a figure which shows the result of having investigated the influence of the hole diameter and thickness of a base with respect to the maximum temperature of a fixture. Panel A represents the influence of the hole diameter, and panel B represents the influence of the thickness.
- the temperature control agent of the present invention is characterized by containing an aliphatic compound having a melting point of 35 ° C. or more and 65 ° C. or less and a water solubility (g / 100 mL) at 20 ° C. of 5 or less.
- the solubility is preferably 3 or less, more preferably 1 or less.
- the preferred melting point varies depending on the use of the thermal material, but is generally preferably 38 ° C. or more and 60 ° C. or less.
- the aliphatic compound having such characteristics is selected from higher ⁇ -olefin polymers, various paraffin waxes such as vegetable, animal or petroleum type, myristyl myristate, polyester polyol, polyoxyethylene fatty acid diester, etc. can do.
- the higher ⁇ -olefin polymer is obtained by copolymerizing two or more ⁇ -olefins having 10 to 35 carbon atoms or one or more ⁇ -olefins having 10 to 35 carbon atoms and one or more other olefins. Point to.
- the higher ⁇ -olefin polymer used in the present invention may be a main chain crystalline polyolefin in which the main chain is folded and crystallized, but a side chain having a certain long chain ⁇ -olefin in the side chain. Crystalline polyolefin is preferred. Side chain crystalline polyolefin has a sharp melting behavior. When not melted, there is no stickiness, which is convenient. Such side-chain crystalline polyolefin is manufactured and sold under a trade name such as “HS Crysta” (Toyoku Oil), and is commercially available.
- HS Crysta Toyoku Oil
- paraffin wax eg, Nippon Seiwa
- myristyl myristate eg, Croda Japan
- polyester polyol eg, DIC, Toyokuni Seiyaku
- polyoxyethylene fatty acid diester eg, Sanyo Kasei
- higher ⁇ -olefin polymer eg, Toyo Adress
- the water solubility at 20 ° C. can be measured by dissolving the sample in 100 g (100 ml) of water at 20 ° C. and reading the mass of the limit amount (dissolved maximum amount) that cannot be dissolved.
- the aliphatic compound contained in the temperature control agent of the present invention can be in the form of pellets, powders, blocks, etc. at room temperature. From the viewpoint of convenience in mixing with the exothermic composition, it is advantageous to use a powder at room temperature. Those in the form of pellets, blocks and the like can be pulverized (for example, freeze pulverized) before mixing to be powdered and uniformly mixed.
- the temperature control agent of the present invention may contain one or more of the above aliphatic compounds, and further, for the purpose of improving physical properties, a lipophilic adsorbent, an inclusion compound (for example, cyclodextrin).
- a sustained release agent, a plasticizer and the like may be optionally contained.
- a hot melt adhesive or a plasticizer for improving coating spinnability can be mentioned. It is done.
- the mechanism by which the stability of the heat generation characteristics is generated by using the temperature control agent of the present invention is not limited by a specific theory, but is generally considered as follows.
- a temperature control agent When a temperature control agent is added to the exothermic composition, when the exothermic temperature reaches the melting point of the temperature control agent, the temperature control agent melts and covers the periphery of the iron powder, thereby inhibiting the oxidation reaction and increasing the temperature. Is suppressed.
- a temperature control agent is added to the layer of the air-permeable packaging material, the temperature control agent melts when the exothermic temperature reaches near the melting point of the temperature control agent, and the holes or needle holes of the porous film are blocked. As a result, the oxygen permeation amount to the exothermic composition is reduced, and the temperature rise is suppressed.
- the type and content of the temperature control agent are selected so as to achieve the required heat generation performance.
- a hot compress warmed directly on the skin preferably has an exothermic temperature of around 40 ° C., but if it exceeds 43 ° C., protein denaturation occurs and the risk of low-temperature burns is said to increase. For this reason, if the design does not exceed 43 ° C. and there is a possibility that the heat generation temperature becomes 43 ° C. or higher, it is necessary to quickly suppress the temperature rise to a suitable level of about 40 ° C. On the other hand, it is not desirable that the temperature continues to decrease after the suppression because the thermal effect is reduced. Further, in the case of a warm compress warmer directly applied to the skin, which is applied to the abdomen of a delicate woman for the purpose of alleviating menstrual pain, mild heat generation of 40 ° C. or less is preferable.
- disposable warmers of the type affixed to clothing are used around the maximum temperature of 55 ° C because the skin is protected by clothing, but the design does not exceed the maximum temperature of 63 ° C described in the product labeling. is required.
- the bowl-disposable disposable body warmer it is used at a relatively high temperature in a short time, but since it directly touches the skin, a design that does not exceed around 55 ° C. is required.
- a melting point close to the desired maximum temperature for example, ⁇ A melting point of about 20 ° C. to about 10 ° C. (ie, the maximum temperature is within + about 20 ° C. to ⁇ 10 ° C. of the melting point), preferably a melting point within ⁇ 8 ° C., more preferably the maximum temperature
- ⁇ A melting point of about 20 ° C. to about 10 ° C. (ie, the maximum temperature is within + about 20 ° C. to ⁇ 10 ° C. of the melting point)
- a melting point within ⁇ 8 ° C. more preferably the maximum temperature
- One or two or more aliphatic compounds having a melting point within ⁇ 5 ° C. can be appropriately selected, and the addition amount, addition method, addition of optional components, and the like can be designed.
- paraffin wax having a melting point of 62 ° C. can be selected.
- exothermic composition contains at least metal powder, salts, water and activated carbon, and further contains the temperature control agent of the present invention.
- the temperature control agent is as described above.
- iron powder is generally used, but other metal powder may be used as long as it generates oxidation heat.
- salts inorganic salts such as sodium chloride, potassium chloride and magnesium chloride are generally used.
- the exothermic composition of the present invention contains activated carbon, but may further contain a water retention agent other than activated carbon (for example, a water-absorbing polymer, vermiculite, sawdust, silica-based material, etc.). In addition, various other conventionally known components can be added as necessary.
- the weight of the exothermic composition is 100%, iron 35 to 80% by weight, activated carbon 1 to 20% by weight, salts 1 to 10% by weight, water 5 to 45% by weight, activated carbon
- iron is 45 to 70% by weight
- activated carbon is 1 to 15% by weight
- salts are 2 to 5% by weight
- water is 20 to 30% by weight
- water retention agents other than activated carbon are 1 to 10% by weight.
- the blending amount of the temperature control agent can be appropriately selected according to the purpose of use of the thermal material and the maximum temperature to be achieved as described above.
- the temperature control agent of the present invention is added in an amount of 3 to 40 parts by weight, preferably 3 to 30 parts by weight, with respect to 100 parts by weight of the exothermic composition having such a composition.
- the exothermic composition can be produced by mixing the above essential components and optional components selected as necessary under low oxygen or oxygen-free conditions by a known method.
- the exothermic composition may be a powder, which may be further processed by a known method, and may be formed into a form such as a sheet by rolling or a cube by tableting.
- a binder such as cellulose (for example, crystalline cellulose), lactose, starch, dextrin, sucrose ester, Teflon (registered trademark), polyethylene glycol, carboxymethyl cellulose may be added. .
- a binder such as crystalline cellulose is added in an amount of 10 parts by weight or more, preferably 10 to 30 parts by weight per 100 parts by weight of the exothermic composition.
- a tablet having a desired appropriate hardness can be obtained.
- Such a solid exothermic composition is preferable in order to prevent sealing failure due to powder adhering to the sealed portion of the bag or container at the time of encapsulation, and to eliminate variations in the exothermic temperature.
- salt may be mixed simultaneously at the time of mixing a powder raw material, you may add as salt water.
- the exothermic composition of the present invention containing such a temperature control agent is a breathable packaging material (for example, 17,000 to 18) used for an exothermic composition-containing bag for containing the exothermic composition according to the JIS S4100 exothermic test. , 000 seconds / 100 cc (JIS P8117 method (Gurley method)) is measured over time to determine whether the desired maximum temperature has been achieved by measuring the temperature change when reacted with oxygen in the air.
- the exothermic test performed for this purpose may be performed by appropriately changing the experimental conditions so as to reflect the assumed actual use state.
- the packaging material exothermic composition is filled in the exothermic composition housing bag.
- the bag filled with this exothermic composition can also be used as a thermal material (for example, a so-called non-stick type warmer).
- the exothermic composition-containing bag is formed so that at least a part thereof has air permeability.
- the exothermic characteristics of the exothermic material change. Therefore, known ones can be appropriately selected and used so that they are in a desired range according to the purpose of use.
- a breathable packaging material of 10,000 to 40,000 seconds / 100 cc (JIS P8117) is used. Further, for example, 2,000 to 7,000 seconds / 100 cc is used in a shoe warmer. Therefore, as a breathable packaging material for a bag for containing a heat generating composition, a packaging material having an air permeability of 2,000 to 40,000 seconds / 100 cc is generally used. In the case of a heating material designed to be used at a high temperature and / or in a short time, such as a meridian stimulation heating tool, a packaging material of 0 to 10,000 seconds / 100 cc can be used. By using the temperature control agent of the present invention, precise air permeability management becomes unnecessary depending on the use of the thermal material, and the allowable range of the breathable packaging material that can be used is expanded.
- the breathable packaging material used for the bag body in the present invention may be a film or sheet that is completely or partially breathable.
- a single-layer or laminated porous film or sheet is used alone, or It is used in combination with a woven or non-woven fabric or the like, or a single layer or laminated non-porous film or sheet is used alone or in combination with a woven or non-woven fabric or the like with needle holes.
- film mainly refers to a simple substance (including a single layer and a laminate; the same shall apply hereinafter) or relatively thin
- sheet mainly refers to a simple substance or a laminate of two or more simple substances or a relatively thick one. Strictly do not distinguish.
- thermoplastic synthetic resin or the like is used as the resin constituting the film.
- polyethylene, polypropylene, polyester, polyamide, polyvinyl alcohol, polyvinyl chloride, polyvinylidene chloride, polyurethane, polystyrene, ethylene-vinyl acetate copolymer, polycarbonate and the like are preferably used alone or in combination.
- it can be appropriately selected according to the necessary required calorific value, temperature, exothermic composition to be used and the like.
- a stretched film preferably a stretched porous film or a sheet containing the stretched film is preferably used as the breathable film or sheet.
- the stretched porous film generally contains an inorganic filler, and air permeability is expressed by forming communication holes by stretching.
- the air permeability can be controlled by controlling the pore diameter and the like.
- a laminating method In the case of stacking, it is usually performed by a laminating method, but is not limited thereto. Any conventionally known method can be applied to the laminate. For example, it may be a method of laminating with an adhesive such as thermal bonding or hot melt adhesive or acrylic or urethane adhesive, and may be full-surface bonding or partial bonding to maintain flexibility. A curtain spray method or a dry laminating method is preferably used.
- Nonwoven fabrics are used in breathable packaging materials from the standpoint of reinforcing the strength of packaging materials and improving machine suitability.
- the nonwoven fabric that may be laminated with the above film those conventionally used in technical fields such as a heating element and a medical heating tool can be suitably used.
- Examples include artificial fibers such as nylon, vinylon, polyester, rayon, acetate, acrylic, polyethylene, polypropylene, and polyvinyl chloride, and natural fibers such as cotton, hemp, and silk, such as spunbond, thermal bond, and spunlace.
- Nonwoven fabric in the form.
- the basis weight of the nonwoven fabric varies depending on the specific gravity of the nonwoven fabric material and the bulkiness due to the difference in the entanglement method, but generally about 10 g / m 2 to about 200 g / m 2 is suitable, especially about 20 g / m 2 to About 100 g / m 2 is preferred.
- a breathable sheet in which a stretched porous film of a thermoplastic synthetic resin is laminated with a nonwoven fabric such as nylon or polyester fiber is generally used in many cases.
- an arbitrary method such as a curtain spray method or a dry laminating method is used.
- a curtain spray method two coating guns are used in one step, and a temperature control agent (containing an auxiliary agent for improving coating performance) is preferably used in the first coating gun as a nonwoven fabric or porous.
- a temperature control agent diluted in an organic solvent with the first gravure roll is applied to the nonwoven fabric or porous film, and the second gravure roll is applied.
- a solvent-based adhesive for adhesion to a nonwoven fabric or a porous film with a roll and pasting them together, a packaging material in which the nonwoven fabric and the porous film are laminated can be obtained.
- a temperature control agent may be applied and coated on a breathable film, for example, a porous film alone, without using a nonwoven fabric, and a packaging material having a temperature control agent layer on the film surface may be produced.
- a packaging material may be used as it is for the production of a disposable body warmer or may be laminated with a non-woven fabric in a later step.
- the back-side packaging material of the flat bag body may be a breathable packaging material as described above or a non-breathable packaging material.
- the non-breathable packaging material can be a single layer or a laminated film or sheet of the resin as described above, and particularly as far as it is suitable for the formation of the exothermic composition-containing bag body, particularly regarding the material, thickness, configuration, etc. There is no limitation.
- the exothermic composition-accommodating bag can be manufactured by adhering the peripheral edge by a method usually used in this technical field, using the packaging material as described above.
- the thermal material can be basically manufactured by enclosing the exothermic composition of the present invention in this bag.
- the manufacture of the bag body and the manufacture of the heat generating material are continuous. First, the peripheral portion of the overlapped packaging material is bonded with a heat seal or adhesive leaving a part, and heat is generated from the open portion. After the composition is charged, the opening is also adhered and the exothermic composition is sealed.
- a device having a small application area and / or a short usage time such as a jig is used in a container having a thickness of, for example, several mm to several cm instead of a flat bag. Also good.
- the packaging materials of various materials as described above can be used as appropriate for the production of the lid (top material) and the container body.
- a packaging material with extremely high air permeability can be used, and therefore, a nonwoven fabric may be used alone. .
- the thermal material may be only a bag (for example, a disposable body warmer that is not attached) or only a container (for example, a tool) filled with the exothermic composition of the present invention.
- Additional elements can be added. These various elements are well-known and may be integrated in the bag body, or may be provided as separate members so as to be combined at the time of use. Examples of additional elements include various fixing means and various parts to be combined at the time of use (for example, containers containing fragrances and drugs, sheets containing water and cosmetics, etc.) There is something to be done).
- the fixing means for example, an adhesive layer or a poultice layer formed on the surface of a part of the bag or container for the exothermic composition so that a thermal material can be attached, and wrapped around a heating target and fixed.
- a band-shaped member, a mask provided with a pocket for accommodating a heating material, a supporter, a wristband, and the like can be given.
- a pedestal may be provided between the container and the pressure-sensitive adhesive layer to adjust the distance and / or space between the application site and the thermal material.
- the thermal material of the present invention uses various drugs or fragrances such as camphor and menthol in combination with an adhesive layer, a poultice layer and other components, or an exothermic composition, and / or a packaging material or container. May be.
- Nonyl acid vanillylamide and the like can be added to the pressure-sensitive adhesive.
- l-menthol, thin load, dl-camphor, peppermint oil, cymol (thymol), menthyl ethyl oxalate and the like can be added to the adhesive.
- a bag body containing at least an exothermic composition of a thermal material is sealed in an outer bag that blocks oxygen and stored until use.
- Such outer bags are also known.
- Materials for the exothermic composition include iron powder (Product No. RDH-3M, Powder Tech Co., Ltd.), activated carbon (Product No. FY-1, Cataler Co., Ltd.), vermiculite (Vermitech Co., Ltd.), water-absorbing polymer (Product No. ST- A basic composition exothermic composition was produced using 500D, Sanyo Chemical Industries, Ltd., purified salt (Namio salt, Nihonkaikai Co., Ltd.), and water. Exothermic compositions were manufactured using various aliphatic compounds shown in Table 1, thermal materials (disposable body warmers) using these exothermic compositions were manufactured, and the exothermic characteristics were tested. The composition of the exothermic composition was as shown in Table 2. (In the table, the unit of content is “parts by weight”.)
- Each compound shown in Table 1 is pulverized in a mortar if the property is in a pellet form, frozen in a freezer for 2 hours in a block shape, and pulverized in a barmix mixer (manufactured by ESGE). Powdered. Each compound was mixed in a conventional exothermic composition (“basic formulation”) with a standard formulation in the formulation amounts shown in Table 2.
- a polyethylene terephthalate (PET) spunlace nonwoven fabric 30 g / m 2 basis weight (manufactured by Shinwa) and a polyethylene porous film 70 ⁇ m thick (manufactured by Kojin Film & Chemicals) are dried.
- a pressure-sensitive adhesive packaging material having a polyethylene film thickness of 60 ⁇ m (manufactured by J-Film) / acrylic solvent-based pressure-sensitive adhesive (manufactured by DIC) / release paper basis weight of 40 g / m 2 (manufactured by Sanei Kaken) was used.
- Each packaging material was cut into a width of 95 mm and a length of 130 mm, and a three-side sealed bag was formed with an impulse sealer with a width of 5 mm, filled with 35 g / sheet of the exothermic composition of each of Examples 1 to 16 previously mixed, and the other one was 5 mm.
- a disposable body warmer was prepared by sealing with a width of.
- composition containing the basic composition and the composition containing the compound of the comparative example were produced in the same manner, and a disposable body warmer was produced in the same manner.
- the exothermic test was conducted under the conditions of an ambient temperature of 20 ⁇ 1 ° C., an ambient humidity of 55 to 70%, and a hot plate temperature of 30 ⁇ 1 ° C. according to the method of JIS S4100 “Ususe Sukaiiro”.
- Examples 17 to 18 As the exothermic composition, the composition having the basic composition shown in Table 2 was used.
- the front side packaging material was manufactured as follows. 35 g of polypropylene spunbonded nonwoven fabric (manufactured by Shinwa Co., Ltd.) and 70 ⁇ m thick polyethylene porous film (manufactured by Kojin Film & Chemicals Co., Ltd.) were used as temperature control agents in Examples 17 and 18 (Examples 5 and 3 respectively) instead of adhesive. Were applied by a hot melt curtain spray method (10 g / m 2 ) and bonded together.
- the material cut out by 95mm in width x 130mm in length is peeled off by hand once and then sprayed with synthetic rubber (styrene butadiene) spray paste (manufactured by Sumitomo 3M), and the air permeability is 9,000 seconds / 100cc (JIS P8117).
- An adhesive sheet was produced.
- the back side packaging material was the same as described above.
- a disposable body warmer was manufactured in the same manner as described above, and an exothermic test was conducted.
- the melting point of each aliphatic compound was measured using a differential scanning calorimeter.
- a differential scanning calorimeter DSC6220, which is connected to a fully automatic cooling unit, an analysis system (EXSTAR6000 thermal analysis rheology system, software is DSC Muse measurement software and DSC Muse standard analysis software), and all the measuring instruments above are Seiko Instruments Inc.
- an open type sample container made of Al ⁇ 5.2 H2.5 (50 ⁇ l) and an open type sample container made of Al (crimp cover) were used.
- each aliphatic compound was dissolved in 100 g (100 ml) of water at 20 ° C., and the solubility in water was measured by reading the limit amount of mass that became insoluble.
- the maximum temperature of the disposable body warmer when the temperature control agent was not used was 70 ° C or higher.
- the exothermic temperature was controlled to the maximum temperature corresponding to the melting point of the used temperature control agent (FIGS. 1, 2, and 4).
- the disposable body warmers using the compounds of Comparative Examples 1 to 4 did not show a temperature control effect, or the heat generation was suppressed regardless of the melting point and sufficient heat generation was not obtained (FIG. 3).
- the temperature suddenly increased immediately after being covered with the cloth and reached around 80 ° C.
- the temperature rise was slightly observed after being covered with the cloth, the rise was suppressed at about 45 ° C., and thereafter kept in an appropriate temperature range.
- cup-shaped molded product (container body) is built in a metal prototype mold (upper: pressing mold, lower: receiving mold), and heated to 100 ° C or higher up and down It can be manufactured by sandwiching a moldable non-woven fabric in and pressurizing with an air cylinder for several seconds.
- the container body was manufactured by the following method.
- a wooden prototype (upper: cylindrical rod, lower: receiving wood with a hole) was prepared, and the pressing surface of the cylindrical rod was heated to 200 ° C. with an experimental hot stirrer or hot plate. .
- the moldable nonwoven fabric placed on the receiving wooden mold was pressed with a heated rod to produce a cup-shaped molded product.
- the moldable PET nonwoven fabric (Asahi Kasei Co., Ltd., “Smash Y15250”)
- the moldable polypropylene (PP) nonwoven fabric (Idemitsu Unitech Co., Ltd., “Stratec RW2250”)
- PET / PP nonwoven fabric for top materials top PET / LLDPE / PP non-woven fabrics for materials are all Gurley method (Kumaya Riki Kogyo Co., Ltd., GURLEY)
- the air permeability measured by DENSOMETER is 0 sec / 100 cc, and there is no oxygen ventilation resistance that inhibits the iron powder oxidation reaction.
- the exothermic composition is composed of iron powder (Powder Tech Co., Ltd., reduced iron powder “NRD-3K”), activated carbon (Nippon Enviro Chemicals Co., Ltd.), coconut shell activated carbon “S- 5 "), salt (Nihonkaikai Co., Ltd., common salt), water-absorbing polymer (Sanyo Kasei Co., Ltd., polyacrylic acid resin” ST-500D "), crystalline cellulose (Asahi Kasei Chemicals Co., Ltd., crystalline cellulose” Using Theolas TG101 ”) and the compound of Example 1 (Toyokoku Oil Co., Ltd., higher ⁇ -olefin polymer HS crystal 6100, melting point 59.5 ° C) as a temperature control agent, it was produced as follows.
- the composition of the exothermic composition was as shown in Table 4. (In the table, the unit of content is “parts by weight”.) First, in consideration of bulk specific gravity and particle size, cellulose, a temperature control agent, a water-absorbing polymer, activated carbon, and iron were weighed and added to a beaker. Stir evenly with a medicine spoon to eliminate uneven distribution of each ingredient. 1 g of this mixed raw material was weighed and tableted with Fuji Chemical Machine Co., Ltd. “Desktop prototype tablet press quick mini FY-TQM-30” (tablet pressure 10 KN). The pressing mold was 13.9 mm in diameter and the receiving mold inner diameter was 14 mm, and a cylindrical tablet having a diameter of 14 mm and a thickness of 4 mm was produced.
- the fixtures were manufactured as follows. First, the tablets are put in the molded nonwoven fabric container bodies produced as described above, and the top material (PET / PP nonwoven fabric, Teijin Ltd. “Unicel Melfit BT060” or PET / LLDPE / PP nonwoven fabric, Idemitsu Unitech Co., Ltd., “Stramity MEM1060”, or outer bag film KOP 30 ⁇ m / LDPE 25 ⁇ m / LLDPE 30 ⁇ m (no breathability) (Meiwa Packs Co., Ltd.)) was attached. A double-sided adhesive tape material was attached to the bottom part outside the container directly or via a pedestal to produce a jig schematically shown in FIG.
- the top material PET / PP nonwoven fabric, Teijin Ltd. “Unicel Melfit BT060” or PET / LLDPE / PP nonwoven fabric, Idemitsu Unitech Co., Ltd., “Stramity MEM1060”, or outer bag film KOP
- the pedestal is made by pasting a 0.75 mm thick drawing paper with a woodworking bond (Konishi Co., Ltd.) and drilling a hole (3-5 mm in diameter) with a drill in the center of a circle (diameter 16 mm) punched out with a punch. It was used. Using a syringe from the top material, 0.3 g of 8.8 wt% salt water was injected into a 1 g tablet unless otherwise stated. However, in Reference Example 1 (0929-1 formulation), salt was added during the production of the mixed raw material, and 0.4 g of water was added to 1 g of the tablet after tablet formation. The completed fixture was sealed in a KOP film bag (KOP / LDPE / LLDPE commercially available outer bag for Cairo) for oxygen / water vapor permeation barrier.
- KOP film bag KOP / LDPE / LLDPE commercially available outer bag for Cairo
- the exothermic test was conducted in a thermostat of W615 x D410 x H60mm (using an 8mm-thick vinyl chloride plate) installed in a temperature-controlled room with a room temperature of 20 ° C and a humidity of 65%. Circulate warm water and control the surface temperature of the heater (vinyl chloride plate) to 30 ° C. Put the fixture sample on the bottom of the container and attach a temperature measuring sensor to the center of the bottom with double-sided tape. The temperature was measured by attaching it to a vinyl chloride plate on the surface of the heater (the temperature measuring device was Sato Shoji Co., Ltd., “THERMOMETER 47SD”, and the sensor was Anritsu Keiki Co., Ltd., “ST-22E-003”).
- Examples 19 and 20 were used as the exothermic composition tablets of the tool.
- Table 5 shows the maximum temperature of the jig manufactured using each combination of tablet, container and top material.
- Table 6 below and FIG. 7 show the results (maximum temperature) when the plate temperature assumed to be the skin temperature is changed to 27 ° C., 30 ° C., and 33 ° C. at room temperature of 20 ° C.
- the maximum temperature of all commercially available thermal materials fluctuated with changes in the plate temperature and room temperature, whereas the thermal materials using the exothermic composition containing the temperature control agent of the present invention had the highest temperature. It was shown that it can be used at a predetermined maximum temperature without being affected by the user's skin temperature or room temperature during use.
- the tablet of Example 22 tested in Table 7 shows an increase in the maximum temperature of about 4 to 6 ° C., whereas the maximum temperature when measured using a 30 ° C. hot water circulation plate is 57 ° C. Although it was seen, this is probably because heat was stored on the foamed polyethylene surface due to the lack of hot water circulation.
- the difference in the maximum temperature with or without flannel coating was 0.2 to 2.4 ° C. for the thermal material of the present invention, whereas commercially available warmers, HM and R measured in the same manner for comparison were 6 0.degree. C. and 5.2.degree. Therefore, while a commercially available body warmer is covered with a cloth, the maximum temperature fluctuates. On the other hand, a tool using a heating agent containing the temperature control agent of the present invention does not change the maximum temperature even when covered with a cloth. It was shown to be small.
- Table 9 shows the results of measuring 5 samples each of the jigs (container Y15250, top material MEM1060) using powder and tablets.
- the exothermic composition of the present invention can provide a more stable maximum temperature by being in a solid form, and in particular, in a thermal material in the form of a jig with a small amount of exothermic composition to be filled. Has shown that a solid form exothermic composition is more suitable.
- the maximum temperature of the tool on the skin surface can be adjusted by adjusting the distance between the tool body and the skin application surface with the thickness of the pedestal or adjusting the hole diameter of the pedestal. It was.
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Abstract
Description
〔1〕 酸素と反応して発熱する発熱組成物を含む温熱材の発熱温度を制御するための温度制御剤であって、35℃以上65℃以下の融点を有し20℃での水溶解度(g/100mL)が5以下の脂肪族化合物を一種以上含有することを特徴とする温度制御剤;
〔2〕 前記温度制御剤が、高級α-オレフィン重合体、パラフィンワックス、ミリスチン酸ミリスチル、ポリエステルポリオール、ポリオキシエチレン脂肪酸ジエステルからなる群から選択される一種以上の化合物を含有する、前記〔1〕記載の温度制御剤;
〔3〕 金属粉、塩類、水及び活性炭を含有し酸素と反応して発熱する発熱組成物であって、さらに前記〔1〕又は〔2〕記載の温度制御剤を含有することを特徴とする発熱組成物;
〔4〕 前記〔3〕記載の発熱組成物が収容された少なくとも一部が通気性を有する袋体を含む、温熱材;
〔5〕 加温対象に対して前記袋体を固定する手段を有する、前記〔4〕記載の温熱材;
〔6〕 少なくとも前記袋体が、実質的に酸素を遮断する気密性外袋に収容されている、前記〔4〕又は〔5〕記載の温熱材;
〔7〕 使い捨てカイロ又は医療機器のいずれかとして使用される、前記〔4〕~〔6〕のいずれか1項記載の温熱材;
〔8〕 前記医療機器が、温湿布又は経絡刺激用温熱具のいずれかである、前記〔7〕記載の温熱材;
〔9〕 酸素と反応して発熱する発熱組成物を収容する袋体を構成するための通気性包材であって、前記〔1〕又は〔2〕記載の温度制御剤を含有する層を含むことを特徴とする、通気性包材;
〔10〕 前記温度制御剤を含有する層が、通気性フィルムもしくはシート層と不織布層との間又は通気性フィルムもしくはシート上に設けられている、前記〔9〕記載の通気性包材;
〔11〕 金属粉、塩類、水及び活性炭を含有し酸素と反応して発熱する発熱組成物が収容された袋体を含む温熱材であって、前記袋体の少なくとも一部が、前記〔9〕又は〔10〕記載の通気性包材により構成されていることを特徴とする、温熱材;
〔12〕 加温対象に対して前記袋体を固定する手段を有する、前記〔11〕記載の温熱材;
〔13〕 少なくとも前記袋体が、実質的に酸素を遮断する気密性外袋に収容されている、前記〔11〕又は〔12〕記載の温熱材;
〔14〕 使い捨てカイロ又は医療機器のいずれかとして使用される、前記〔11〕~〔13〕のいずれか1項記載の温熱材;
〔15〕 前記医療機器が、温湿布又は経絡刺激用温熱具のいずれかである、前記〔14〕記載の温熱材;
〔16〕 発熱組成物が固形形態である、前記〔3〕記載の発熱組成物;
〔17〕 前記〔16〕記載の発熱組成物を含む温熱材;
〔18〕 経絡刺激用温熱具である、前記〔17〕記載の温熱材
が提供される。
- 布団の被覆による低温火傷のリスクが低減された、就寝時も安全に使用できる温熱材;
- 靴の種類によらず安定した発熱が得られ、靴を脱いだ際も急激な温度上昇をすることのない、安全性の高い靴用使い捨てカイロ;
- 高度な温度安定性を有し、安全性及び有効性の高い経皮吸収型医療用温湿布;
- 高温度帯でも最高温度を制御することで安全に使用できるお灸などの経絡刺激用温熱具としての温熱材
などが提供される。
本発明の温度制御剤は、35℃以上65℃以下の融点を有し20℃での水溶解度(g/100mL)が5以下の脂肪族化合物を含有することを特徴とする。上記の溶解度は、好ましくは3以下、さらに好ましくは1以下である。好ましい融点は、温熱材の用途により変動するが、一般的には好ましくは38℃以上60℃以下である。
本発明の発熱組成物は、少なくとも金属粉、塩類、水及び活性炭を含有し、さらに本発明の温度制御剤を含有する。温度制御剤は、上述のとおりである。
発熱組成物は、発熱組成物収容用袋体に充填される。この発熱組成物が充填された袋体は、そのまま温熱材(たとえば、いわゆる貼らないタイプのカイロなど)として使用することもできる。一般に、発熱組成物収容用袋体は、少なくとも一部分が通気性を有するように形成されている。
また、灸具のように、適用面積が狭い、及び/又は使用時間が短いものは、扁平状袋体ではなく、たとえば数mm~数cm程度の厚さのある容器に収容して使用してもよい。この場合も、蓋(トップ材)及び容器本体の製造には、上記のような各種の材質の包材を適宜用いることができる。なお、上記のとおり、灸具のような高温及び/又は短時間の発熱を利用するものの場合には通気性が非常に高い包材を用いることができるので、不織布を単体で使用してもよい。
温熱材は、上記のように本発明の発熱組成物を充填した袋体のみ(たとえば貼らない使い捨てカイロ)又は容器のみ(たとえば灸具)であることができるが、必要に応じて、さらに付加的な要素を追加することができる。これらの各種の要素は公知であり、袋体に一体化されていてもよく、あるいは、使用時に組み合わせるように別部材として提供されてもよい。付加的な要素の例としては、各種の固定手段や、使用時に組み合わせるべき各種のパーツ(たとえば、香料や薬剤を含む容器、水や化粧料を含有するシートなど、温熱材の用途に応じて使用されるもの)がある。固定手段としては、たとえば、温熱材を貼付可能とするように発熱組成物収容用袋体又は容器の一部の表面上に形成した粘着剤層や湿布剤層、加温対象に巻きつけて固定するためのバンド状の部材、発熱材を収容するポケットを設けたマスクやサポーターやリストバンドなどが挙げられる。また、温度調節などの目的で、容器と粘着剤層との間に台座を設けて、適用部位と温熱材との間の距離及び/又は空間を調節するようにしてもよい。なお、本発明の温熱材は、カンフル、メントールなどの各種薬剤又は香料を、粘着剤層、湿布剤層その他の構成要素、あるいは発熱組成物、及び/又は包材もしくは容器などに組み合わせて使用してもよい。たとえば、温感受容体として、トウガラシチンキ、トウガラシエキス、トウガラシ末、ショウキョウチンキ、ショウキョウエキス、ショウキョウ末、ウイキョウチンキ、ウイキョウエキス、ウイキョウ末、カプサイシン、カプサイシン誘導体、バニリルブチルエーテル、バニリルアルキルエーテル、ノニル酸ワニリルアミド等を粘着剤に添加することができる。冷感受容体として、l―メントール、薄荷、dl―カンフル、ペパーミント油、サイモール(チモール)、シュウ酸メンチルエチルアミド等を粘着剤に添加することができる。
発熱組成物の材料として、鉄粉(品番RDH-3M、パウダーテック(株))、活性炭(品番FY-1、(株)キャタラー)、バーミキュライト(ベルミテック(株))、吸水性ポリマー(品番ST-500D、三洋化成工業(株))、精製塩(並塩、(株)日本海水)、水を用いて基本配合の発熱組成物を製造した。
表1に示す各種の脂肪族化合物を用いて発熱組成物を製造し、これらの発熱組成物を用いた温熱材(使い捨てカイロ)を製造してその発熱特性を試験した。発熱組成物の組成は、表2のとおりであった。(表中、含有量の単位は「重量部」である。)
発熱組成物として、表2の基本配合の組成物を使用した。表側包材は、以下のようにして製造した。ポリプロピレンスパンボンド不織布35g(シンワ社製)とポリエチレン多孔質フィルム70μ厚(興人フィルム&ケミカルズ社製)とを、接着剤の替わりに実施例17、18の温度制御剤(それぞれ実施例5、3と同じ)を用いてホットメルトカーテンスプレー法で塗工(10g/m2)し、貼り合せた。横95mm×縦130mmに切り出したものを一度手で剥がし、合成ゴム系(スチレンブタジエン)スプレー糊(住友スリーエム社製)を吹きかけて貼り合せ、通気度9,000秒/100cc(JIS P8117)の通気性シートを製造した。裏側包材は上記と同じものを用いた。上記と同様にして使い捨てカイロを製造し、発熱試験を行った。
各脂肪族化合物の融点を、示差走査熱量計を用いて測定した。測定装置としては、全自動冷却ユニット、解析システム(EXSTAR6000熱分析レオロジーシステム、ソフトはDSC Muse 測定ソフト及びDSC Muse 標準解析ソフト)と接続した示差走査熱量計(DSC6220、以上測定機器は全てセイコーインスツルメンツ社製)を使用し、サンプル容器として、オープン型試料容器 Al製 φ5.2 H2.5(50μl)、及びオープン型試料容器 Al製(クリンプカバー)を使用した。
実施例3の発熱組成物を用いて上記と同一の材料及び方法で作製した使い捨てカイロについて、上記と同じ条件下でJIS S4100「使いすてかいろ」に従って発熱試験を行った。ただし、発熱開始の時点では8枚重ねのネル布による使い捨てカイロ全体の被覆をせず、発熱開始後3時間の時点で、8枚重ねのネルの布で使い捨てカイロ全体を被覆し、さらに発熱を継続させた。ネル布での被覆は、寝具をかけて就寝中の使用状態を模倣するものである。結果を図5に示す。
(1)容器の製造
カップ状の成形物(容器本体)は、金属製の試作金型(上:押す型、下:受け型)にヒーターを組み込み、上下100℃以上に加熱し、上下金型に成形性不織布をはさみ込み、エアシリンダーで数秒間加圧することにより、製造することができる。
代替的に、以下の方法によって容器本体を製造した。木製の試作型(上:円筒状の棒、下:穴を開けた受け用の木型)を用意し、円筒状の棒の押す面を、実験用ホットスターラー又はホットプレートで200℃に加熱した。受け用の木型に載せた成形性不織布を加熱した棒で加圧し、カップ状の成形物を製造した。なお、使用した成形性PET不織布(旭化成(株)、「スマッシュY15250」)、成形性ポリプロピレン(PP)不織布(出光ユニテック(株)、「ストラテックRW2250」)、トップ材用PET/PP不織布、トップ材用PET/LLDPE/PP不織布は、いずれもガーレ法(熊谷理機工業(株)、GURLEY
DENSOMETER)による通気度測定において0秒/100ccであり、鉄粉酸化反応を阻害するような酸素通気抵抗はない。
発熱組成物(錠剤)は、鉄粉(パウダーテック(株)、還元鉄粉「NRD-3K」)、活性炭(日本エンバイロケミカルズ(株)、ヤシガラ活性炭「S-5」)、塩((株)日本海水、並塩)、吸水性ポリマー(三洋化成(株)、ポリアクリル酸系樹脂「ST-500D」)、結晶セルロース(旭化成ケミカルズ(株)、結晶セルロース「セオラスTG101」)及び温度制御剤として実施例1化合物(豊国製油(株)、高級α-オレフィン重合体HSクリスタ6100、融点59.5℃)を使用して、以下のように製造した。発熱組成物の組成は、表4のとおりであった。(表中、含有量の単位は「重量部」である。)
まず、かさ比重や粒径を考慮して、セルロース、温度制御剤、吸水性ポリマー、活性炭、鉄の順に、ビーカーに計量して加えた。薬さじでまんべんなくかき混ぜ、各原料の偏在を無くした。この混合原料を1g計量し、(株)富士薬品機械「卓上型試作打錠機クイックミニFY-TQM-30」で打錠した(打錠圧10KN)。押す型金型は直径13.9mm、受け側金型内径は14mmを使用し、直径14mm、厚み4mmの円筒形の錠剤を製造した。
灸具は、以下のようにして製造した。まず、上記でそれぞれ製造した成形不織布容器本体に錠剤を入れ、容器上部に家庭用のアイロンでトップ材(PET/PP不織布、帝人(株)「ユニセルメルフィットBT060」又はPET/LLDPE/PP不織布、出光ユニテック(株)、「ストラマイティMEM1060」又はカイロ用外袋フィルムKOP30μm/LDPE25μm/LLDPE30μm(通気性なし)(株)メイワパックス)を貼りつけた。容器外部の底部分に、直接又は台座を介して、両面粘着性のテープ材を貼りつけ、図6、パネルAに模式的に示した灸具を製造した。台座は、厚さ0.75mmの画用紙を木工用ボンド(コニシ(株))で貼り合わせ、ポンチで打ち抜いた円形(直径16mm)の中央にドリルで貫通穴(直径3~5mm)をあけたものを使用した。
トップ材から注射器を用いて、別途記載しない限り1gの錠剤に対し8.8重量%塩水0.3gを注入した。ただし、参考例1(0929-1処方)は、混合原料の製造時に塩を加え、錠剤形成後には1gの錠剤に対し0.4gの水を加えた。
出来上がった灸具を、カイロ用酸素・水蒸気透過バリア性のKOPフィルム製袋(KOP/LDPE/LLDPE市販カイロ用外袋)中に密封した。
発熱試験は、周囲温度20±1℃、風速0.5m/s以下(無風状態)、周囲湿度55~70%、温熱器と循環式恒温水槽からなる温熱装置の温熱部30±1℃の条件で、被覆材として綿100%、テックス番手5.905双糸のネル8枚重ねを使用して行なった。ただし、灸具の使用時には皮膚に直接貼付することから、被覆材なしで温熱器表面に直接貼り付けた場合も測定した。
(1)容器素材及びトップ材の影響
本発明の灸具の発熱温度が使用者の皮膚温又は使用時の室温の違いにより影響を受けるか否かを調べた。灸具の発熱組成物錠剤としては、実施例21、22、及び19を使用し、容器包材にはY15250、トップ材にはKOPを使用した。
本発明の灸具は、火を使用しないため、衣服の下に装着して使用することもできる。そこで、衣服を想定してネル布で覆った場合と覆っていない場合とで最高温度が変化するか否かを調べた。
発熱組成物錠剤の処方は実施例19を基本とし、HSクリスタ6100含有量を10.1~33.0重量部まで変化させて使用した(鉄粉43.1重量部、活性炭3.3重量部、吸水性ポリマー4.8重量部、結晶セルロース19.1重量部、HSクリスタ610010.1~33.0重量部で1.0g錠剤を製造後、8.8重量%塩水を0.3g添加)。結果を表8及び図9に示す。
本発明の灸具に使用する発熱組成物として、粉体形態と固形(錠剤)形態とを比較した。発熱組成物の処方としては、実施例19を使用した。ただし、上記のサイズで作製した容器に充填できる粉体の発熱組成物量は0.7gが上限であるため、錠剤も0.7gの発熱組成物で製造し、それに伴い8.8重量%塩水量も0.2gとした。
灸具本体と皮膚粘着層間の台座によって最高温度制御が可能であるか否かを調べた。
本試験においては、灸具本体の下に設ける台座として、厚さ0.75mm/枚の画用紙を用いた。画用紙の貼り合わせは、木工用ボンドで行った。台座は直径16mmとし、重ねる枚数及び孔径を変化させて最高温度を測定した。発熱組成物錠剤の処方は、参考例1を使用した。
結果を図10にそれぞれ示す。パネルAは、画用紙3枚厚の台座の孔径を3,4,5mmと変化させた結果であり、パネルBは、孔のない画用紙の枚数を2,3,4枚として調べた結果である。
2 容器(本体)
3 トップ材
4 台座
5 粘着剤層
Claims (18)
- 酸素と反応して発熱する発熱組成物を含む温熱材の発熱温度を制御するための温度制御剤であって、35℃以上65℃以下の融点を有し20℃での水溶解度(g/100mL)が5以下の脂肪族化合物を一種以上含有することを特徴とする温度制御剤。
- 前記温度制御剤が、高級α-オレフィン重合体、パラフィンワックス、ミリスチン酸ミリスチル、ポリエステルポリオール、ポリオキシエチレン脂肪酸ジエステルからなる群から選択される一種以上の化合物を含有する、請求項1記載の温度制御剤。
- 金属粉、塩類、水及び活性炭を含有し酸素と反応して発熱する発熱組成物であって、さらに請求項1又は2記載の温度制御剤を含有することを特徴とする発熱組成物。
- 請求項3記載の発熱組成物が収容された少なくとも一部が通気性を有する袋体を含む、温熱材。
- 加温対象に対して前記袋体を固定する手段を有する、請求項4記載の温熱材。
- 少なくとも前記袋体が、実質的に酸素を遮断する気密性外袋に収容されている、請求項4又は5記載の温熱材。
- 使い捨てカイロ又は医療機器のいずれかとして使用される、請求項4~6のいずれか1項記載の温熱材。
- 前記医療機器が、温湿布又は経絡刺激用温熱具のいずれかである、請求項7記載の温熱材。
- 酸素と反応して発熱する発熱組成物を収容する袋体を構成するための通気性包材であって、請求項1又は2記載の温度制御剤を含有する層を含むことを特徴とする、通気性包材。
- 前記温度制御剤を含有する層が、通気性フィルムもしくはシート層と不織布層との間又は通気性フィルムもしくはシート上に設けられている、請求項9記載の通気性包材。
- 金属粉、塩類、水及び活性炭を含有し酸素と反応して発熱する発熱組成物が収容された袋体を含む温熱材であって、前記袋体の少なくとも一部が、請求項9又は10記載の通気性包材により構成されていることを特徴とする、温熱材。
- 加温対象に対して前記袋体を固定する手段を有する、請求項11記載の温熱材。
- 少なくとも前記袋体が、実質的に酸素を遮断する気密性外袋に収容されている、請求項11又は12記載の温熱材。
- 使い捨てカイロ又は医療機器のいずれかとして使用される、請求項11~13のいずれか1項記載の温熱材。
- 前記医療機器が、温湿布又は経絡刺激用温熱具のいずれかである、請求項14記載の温熱材。
- 発熱組成物が固形形態である、請求項3記載の発熱組成物。
- 請求項16記載の発熱組成物を含む温熱材。
- 経絡刺激用温熱具である、請求項17記載の温熱材。
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US20200360179A1 (en) * | 2018-02-05 | 2020-11-19 | Ferric Inc. | Temperature control agent, and heat-generating composition and warming device each using same |
JPWO2019151472A1 (ja) * | 2018-02-05 | 2021-02-12 | フェリック株式会社 | 温度制御剤ならびにそれを用いた発熱組成物及び温熱材 |
KR102583470B1 (ko) * | 2018-02-05 | 2023-09-26 | 페릭가부시키가이샤 | 온도 제어제, 발열 조성물 및 이를 사용하는 온열 장치 |
US12042427B2 (en) | 2018-02-05 | 2024-07-23 | Ferric Inc. | Temperature control agent, and heat-generating composition and warming device each using same |
WO2021215089A1 (ja) * | 2020-04-24 | 2021-10-28 | 花王株式会社 | 温熱具 |
KR20230045029A (ko) | 2020-08-11 | 2023-04-04 | 페릭가부시키가이샤 | 발열체의 제조방법 및 발열체 |
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EP3211055B1 (en) | 2021-12-08 |
CN106536671B (zh) | 2021-05-11 |
EP3211055A1 (en) | 2017-08-30 |
JPWO2016063815A1 (ja) | 2017-04-27 |
US20170239085A1 (en) | 2017-08-24 |
EP3211055A4 (en) | 2018-08-29 |
JP6273481B2 (ja) | 2018-02-07 |
CN106536671A (zh) | 2017-03-22 |
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