Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/27—Zinc; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
  • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
  • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
  • A61K8/447—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof containing sulfur
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
  • A61P17/10—Anti-acne agents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q15/00—Anti-perspirants or body deodorants
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
  • A61Q17/005—Antimicrobial preparations
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
  • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/10—Washing or bathing preparations
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
  • A61K2800/58—Metal complex; Coordination compounds
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
  • A61K2800/59—Mixtures
  • A61K2800/592—Mixtures of compounds complementing their respective functions
  • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
  • A61K2800/88—Two- or multipart kits
  • A61K2800/882—Mixing prior to application
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/20—Halogens; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings

Definitions

• Conventional antiperspirants comprising salts of aluminum or aluminum/zirconium are known. These salts function as antiperspirants by forming polymeric complexes which can plug pores, thereby blocking sweat release.
• additional antiperspirant active agents that provide complexes of a size capable of plugging pores to block sweat, that provide deodorant/antibacterial efficacy, and that are less irritating to the skin than the acidic salts in conventional antiperspirants.
• alternative antibacterial and skin protective agents for use in liquid hand soaps and body washes.
• agents in oral care products which can whiten and strengthen teeth, retard erosion, and inhibit bacteria and plaque.
• Some tetrabasic zinc-amino acid complexes do not have the most optimal precipitation kmetics. In another words, their rate of precipitation upon dilution may be too slow or too fast for typical applications. For example, for oral care typical recommended brushing times range from 1 minute to 3 minutes, but an average person brushes for a significantly shorter duration. Typical recommended rinsing times with a mouthrinse is about a minute, but an average person spends much less time.
• a dual component composition to deliver a zinc precipitate to the body which comprises (i) a first component comprising a complex of tetrabasic zinc halide (“TBZH”), e.g., tetrabasic zinc chloride (“TBZC”), and an amino acid or trialkylglycine (TAG) (respectively, “TBZH-AA”, “TBZC-AA”, “TBZH-TAG” and “TBZC-TAG), and optionally, glycerol and (ii) a second component comprising acidified cysteine in aqueous solution with, optionally, glycerol; the first and second components being maintained separate from each other until dispensed and combined for application to the body.
• TZH tetrabasic zinc halide
• TAG amino acid or trialkylglycine
• Tetrabasic zinc chloride (TBZC) or zinc chloride hydroxide monohydrate is a zinc hydroxy compound with the formula Zn 5 (OH)gCl 2 » H 2 0, also referred to as basic zinc chloride, zinc hydroxychloride, or zinc oxy chloride. It is a colorless crystalline solid insoluble in water. While TBZC is substantially insoluble in water, the material is found to be soluble in water in the presence of an amino acid and provides a source of zinc ions without the usage of additional anions (i.e. HQ). While TBZC is preferred in the compositions and methods of the invention, other tetrabasic zinc halides may be used, e.g., tetrabasic zinc fluoride or tetrabasic zinc bromide.
• the TBZH-AA or TBZH-TAG complex contains a halide such as chloride.
• the TBZH-AA is formed by reacting TBZH with the free base of the amino acid, in such case the halide (e.g., chloride) contribution to the complex will be primarily from TBZH.
• the TBZH-AA is formed by reacting TBZH and a hydrohalide salt (e.g., hydrochloride salt) of a basic amino acid to obtain a complex containing TBZH the basic amino acid and halide, in such case the halide contribution to the complex will be from the TBZH and the hydrohalide salt of the amino acid.
• a hydrohalide salt e.g., hydrochloride salt
• a combination of the free base and hydrohalide salt of the amino acid is used as a starting material, and in other embodiments, additional halides can be provided via addition of different halide-containing compounds such as hydrochloric acid, hydrobromide acid, and the like.
• the types and amounts of halide source can be manipulated to achieve a desired pH.
• the TBZH-AA. is formed by reacting TBZH and trialkylgiycine, such as trimethylglycine.
• the TBZH-AA is a TBZC-lysine complex, e.g., formed from a mixture of TBZC and lysine and/or lysine hydrochloride.
• This particular zinc-lysine-chloride complex is sometimes referred to herein as "TBZC-Lys”.
• the tetrabasic zinc - amino acid or TAG - halide complexes e.g. TBZC-Lys
• have key features e.g., conductivity, hydrolysis reaction and protein flocculation
• the TBZH-AA or TBZH-TAG forms precipitates under sweat conditions that can plug the pores and block sweat release. The mechanism is unusual.
• the TBZH-AA or TBZH-TAG hydrolyzes, to provide a relatively insoluble zmc-containmg precipitate, e.g. zinc oxide, thereby permitting further plugging of the pores and/or controlled deposition of zinc compounds on the skin.
• the zinc is moreover antibacterial, and so in addition to providing a precipitate which blocks sweat release from the pores, it provides a deodorant benefit by reducing odor-causing bacteria
• the precipitate formed from the complexes of the invention typically consists of zinc oxide, as well as other compounds and/or complexes.
• Zinc oxide one constituent in the precipitate, is soluble at acidic H, however, and as sweat has a pH of 5-6, the sweat can reduce the levels of precipitation as compared to precipitation levels at neutral or higher pH. Moreover, the sweat can gradually dissolve the depositions, reducing the duration of action of the formulation. Also, the rate of precipitation may be too slow or too rapid.
• the formulation comprising TBZH-AA or TBZH-TAG together with cysteine thus has enhanced efficacy as an antiperspirant. Moreover, the cysteine helps stabilize the TBZH-AA or TBZH-TAG in the formulation prior to administration.
• the TBZH-AA or TBZH-TAG hydrolyzes to distribute a relatively insoluble zinc-containing precipitate.
• the precipitate typically contains one or more of zinc oxide, zinc cysteine, zinc hydroxide, or other zinc-containing compounds. This precipitate is unique in that it will allo plugging of pores on the skin. Furthermore, this reaction is atypical since, in most cases, dilution will increase the solubility of an ionic complex. Additional!)', zinc is antibacterial, so it provides a precipitate which blocks sweat release from the pores while also it providing a deodorant benefit by reducing odor-causing bacteria.
• cysteine Although we have found that use of cysteine with the TBZH-AA or TBZH-TAG complexes form precipitates that are more resistant to sweat, we have also discovered that use of cysteine delays, or under some conditions, even inhibits formation of the precipitate. The amount of cysteine and the pH have an effect on the degree and rate of precipitate formation.
• the dual component compositions of the invention form visible precipitates from less than 1 second to about 20 seconds after mixing the two components even in undiluted or low- diluted form.
• the presence of cysteine can delay precipitation of zinc complexes, but the delay or acceleration of precipitate formation is dependent on other factors as well.
• the kinetics or rate of precipitation can vary depending on factors such as pH, cysteine concentration, and amount of dilution (if any).
• instantaneous precipitation of TBZH-AA or TBZH-TAG complexes is observed upon mixing the two components.
• rapid precipitation means forming a zinc precipitate in 3 minutes or less
• instant precipitation or “instantaneous precipitation” means forming a zinc precipitate in 1 second or less
• delayed precipitation means forming a zinc precipitate between 1 second and up to 3 minutes.
• each stock solution containing, respectively TBZH-AA or TBZH-TAG and acidified cysteine.
• the first component of the stock solution can be prepared by utilization of a standard synthesis procedure for making TBZH-AA or TBZH-TAG.
• preparing a TBZH-AA or TBZH-TAG stock solution includes reacting tetrabasic zinc halide, e.g., tetrabasic zinc chloride, with an amino acid hydroha!ide salt, e.g., lysine-HCl, over water.
• the stock of TBZC-AA can be the main active ingredient in component one.
• Glycerol can be utilized as a co-solvent in component one as well.
• the acidified cysteine stock solution can be prepared by either dissolving cysteine salt in dilute aqueous mineral acid, e.g., hydrochloric acid, or cysteine hydrohalide, such as cysteine-HCL can be dissolved in water.
• Glycerol can also be utilized as a co-solvent in component two.
• the first component comprises TBZH-AA, e.g., TBZC-lys.
• the pH of the first component is alkaline, for example, about 7 to 11 , or about 8 to about 10 or about 9 to about 10.5 or about 9 to 10.
• the pH of the second component is acidic, for example, about 2 to about 6 or about 2 to about 5 or about 3 to about 6 or about 4 to about 5 or about 4.5 to about 5.
• the pH of the second component is typically achieved by dissolving the cysteine in an acid, e.g., a mineral acid such as a hydrohalide, e.g., hydrochloric acid, and/or acidification can be achieved by dissolving cysteine monohydrohaiide, e.g., monohydrochloride, in water, preferably deionized water.
• an acid e.g., a mineral acid such as a hydrohalide, e.g., hydrochloric acid
• acidification can be achieved by dissolving cysteine monohydrohaiide, e.g., monohydrochloride, in water, preferably deionized water.
• the pH of the two components when mixed is about 4 to about 8, in another embodiment about 5 to 8, in another embodiment about 5 to about 7, in another embodiment about 5.5 to about 7, and in another embodiment about 5.5 to about 6.5.
• the pH of each component is tailored to achieve the desired pH upon mixing to result the desired rapid rate of precipitation.
• the first and second components are aqueous compositions.
• the first component will contain about 10 to about 85% water, in another embodiment about 20 to about 85% water, in another embodiment about 20 to about 25% water, and in yet another embodiment abo 30 to about 33% water.
• the second component will typically contain about 10% to about 95% water, in another embodiment about 20 to about30% water, in another embodiment about 90%) to about 95% water.
• the amount of water in each component will vary depending upon the final product form in order to achieve the desired concentration when the components are mixed. For example, dentifrices typically contain 10 to 25 % total water, mouthwashes typically contain 50 to 90 % total water, personal care products such as antiperspirants typically contain 10 to 20% total water.
• the precipitation time and pH values of the mixtures are affected by many factors, including e.g., water concentration. More water generally leads to more rapid precipitation and higher pH values of the mixture.
• a dual component composition to deliver zinc to the body which comprises (i) a first component comprising a zinc tetrabasic zinc - amino acid or TAG - halide complex (TBZH-AA or TBZH-TAG) e.g., TBZC-lys, and (ii) a second component comprising cysteine in free or in orally or cosmetically acceptable salt form, the first and second components being maintained separate from each other until dispensed and combined for application to the body.
• body includes any site on the body where it is desirable to deposit zinc ions, e.g., skin, in particular pores of sweat glands, and the oral cavity, in particular soft and hard (teeth) tissues.
• the compositions may be oral care products, e.g., dentifrice or mouthrinse, or personal care products, such as antiperspirants, liquid hand soap or body wash, and skin lotions, creams and conditioners.
• the first component, or component one, containing TBZH-AA or TBZH-TAG is mixed with the second component, or component two, containing acidified cysteine.
• the weight ratio of component onexomponent two after mixing is typically about 1 :1 , but can vary somewhat depending on the compositions of the specific components and the specific dispensing means used, for example, about 5: 1 to about 1 :5, in another embodiment about 1 :2 to about 2: 1.
• the dual component TBZH-AA or TBZH-TAG /cysteine combination is useful in oral care products, for example dentifrice or mouthrinse.
• a dual component formulation comprising the TBZH-AA or TBZH-TAG /cysteine combination provides an effective concentration of zinc ions to the enamel, thereby protecting against erosion, reducing bacterial colonization and biofilm development, and providing enhanced shine to the teeth.
• the formulation is diluted and provides a stabilized precipitate that plugs the dentinal tubules, thereby reducing the sensitivity of the teeth.
• the formulations comprising the TBZH-AA or TBZH-TAG /cysteine combination do not exhibit the poor taste and mouthfeel, poor fluoride delivery, and poor foaming and cleaning associated with conventional zinc -based oral care products using soluble zinc salts.
• compositions e.g., methods of reducing sweat comprising applying the composition to skin, methods of killing bacteria comprising contacting the bacteria with the composition, and methods of treating or reducing dental hypersensitivity, erosion, and plaque, comprising applying the composition to the teeth, as well as methods of making such compositions.
• the two components of the composition of the invention are mixed and applied to the body, e.g., skin or oral cavity.
• the mixing is typically performed just before or during application to the body so that upon application to the body the precipitate is formed at the desired site, e.g., at pores of sweat glands or at the openings of dentinal tubules.
• the two components are mixed during application, e.g., brushing with a dentifrice where the two components are applied to a toothbrush which are mixed during brashing.
• the methods of the invention takes advantage of the property of the precipitate being formed in 3 minutes or less after mixing to deliver maximal amount of zinc to the desired body sites.
• glycerol is added to the first component, second component or both which results in delay of precipitate formation, typically a delay of about 1 to 20 seconds, in one embodiment about 1 to 10 seconds, in another embodiment about 1 to 5 seconds, and in another embodiment about 1 to 3 seconds, as compared to a control formulation without glycerol, in addition to delaying precipitation, the glycerol can also function as a humectant.
• a two component system wherein a first component comprises the TBZH-AA or TBZH-TAG complex and the second component comprises cysteine.
• a first component comprises the TBZH-AA or TBZH-TAG complex
• the second component comprises cysteine.
• the cysteine is present in an amount effective to result in rapid precipitation (instant or delayed) when the two components are mixed together.
• the two components are mixed whereby the precipitate does not form while mixing, but does form at the desired body location upon application.
• the two component system is particularly advantageous to maximize the amount of precipitation at the desired site during use, e.g., at dentinal tubules, tooth surface, pores of sweat glands, and the like.
• the dual component compositions of the present invention are packaged in a suitable dispensing container in which the components are maintained physically separated and from which the separated components may be dispensed synchronously, e.g., as a combined ribbon for application to a toothbrush.
• a suitable dispensing container in which the components are maintained physically separated and from which the separated components may be dispensed synchronously, e.g., as a combined ribbon for application to a toothbrush.
• Such containers are known in the art.
• An example of such a container is a two compartment dispensing container, such as a pump or a tube, having collapsible sidewafls, as disclosed in U.S. Pat. No.
• the tube body is formed from a collapsible plastic web such as polyethylene or polypropylene and is provided with a partition within the container body defining separate compartments in which the physically separated components are stored and from which they are dispensed through a suitable dispensing outlet.
• the two components can be delivered by two separate chambers of a bottle into a mixing cup. Upon mixing, the mixture can be transferred to a human mouth and a rinse can be carried out. When the components are dispensed, they will mix in the mixing cup forming a slightly delayed precipitate that will react with appropriate kinetics as to ensure ail precipitation forms within the mouth.
• composition 1 a dual component composition (Composition 1) comprising (i) a first component comprising a tetrabasic zinc-amino acid or TAG-halide complex and (ii) a second component comprising acidified cysteine in free or in orally or cosmetically acceptable salt form, wherein the two components are maintained separate from each other until dispensed and combined for application to the body, e.g.,
• Composition 1 wherein the tetrabasic zinc halide is TBZC.
• composition 1 or 1.1 wherein the amino acid source is at least one of a basic amino acid, lysine, arginine, and glycine.
• compositions wherein the trialkyl glycine is a C1-C4 alkyl glycine or trimethyl glycine.
• compositions wherein the pH of the first component is 7 to 1 1 or 8 to 10 or 9 to 10; and the pH of the second component is 4 to 8 or 5.5 to7 or 5.5 to 6.5.
• the zinc amino acid halide is made by combining TBZX with an amino acid .
• any of the foregoing Compositions which upon dilution with water, provides a precipitate comprising zinc oxide in complex with cysteine, and optionally additionally comprising zinc oxide, zinc carbonate, and mixtures thereof.
• compositions wherein the total amount of zinc present in the composition when the two components are mixed is about 0.2 to about 9%, or about 0.6% to about 1% or about 2%to about 3% by weight of the total composition.
• the about of zinc present in the first component is about 0.6% to about 2%, or about 0.8%) to about 1.5% or about 1% to about 1.2% by weight of the first component,
• compositions wherein the ratio of zinc to cysteine is from about 5: 1 to about 10: 1 by weight of the total composition.
• compositions wherein the cysteine is a cysteine hydrohalide, optionally cysteine hydrochloride.
• compositions wherein a zinc precipitate forms within 30 seconds, or 1 second to 30 seconds, or 1 to 15 seconds or 1 to 3 seconds after mixing the two components.
• compositions further comprising an orally or cosmetically acceptable carrier in the first component, second component or both.
• compositions further comprising an orally or cosmetically acceptable carrier, and which is an oral care product selected from dentifrice or mouthwash, or a personal care product, selected from antiperspi rants, deodorants, liquid hand soap, body wash, dermal lotions, dermal creams, and dermal conditioners.
• an orally or cosmetically acceptable carrier selected from dentifrice or mouthwash, or a personal care product, selected from antiperspi rants, deodorants, liquid hand soap, body wash, dermal lotions, dermal creams, and dermal conditioners.
• composition 1, et seq. comprising (i) combining a zinc ion source, an amino acid or TAG source, a halide source (wherein the halide source can be part of the zinc ion source, the amino acid or TAG source, or a halogen acid), in a fluid (e.g., aqueous) medium optionally containing glycerol, optionally isolating the complex thus formed in solid form and placing the material thus formed into a first container, (ii) placing cysteine optionally with glycerol, and optionally with a hydrohalide, in a second container physically separate from the first container. Either or both of the materials in the separate containers can optionally be combined with a cosmetically or orally acceptable carrier.
• a fluid e.g., aqueous
• cysteine optionally with glycerol
• hydrohalide optionally with a hydrohalide
• composition 2 which is an antiperspirant or deodorant product comprising (i) a first component comprising a tetrabasic zmc-amino acid or TAG-halide complex and (ii) a second component comprising acidified cysteine in free or in orally or cosmetically acceptable salt form, wherein the two components are maintained separate from each other until dispensed and combined for application to the body, and wherein either or both components additionally comprise a cosmetically acceptable carrier, e.g. in accordance with any of the scopes of Composition 1 , et seq. , e.g.
• Composition 2 which, upon mixing and use, provides a precipitate to the skin, comprising zinc oxide in complex with cysteine, and optionally additionally comprising zinc oxide, zinc carbonate, and mixtures thereof.
• composition 2 or 2.1 wherein tetrabasic zinc halide complex is TBZC, optionally in hydrate form.
• composition 2 or 2.1 wherein the cosmetically acceptable carrier comprises one or more ingredients selected from water-soluble alcohols (such as C 2 _8 alcohols including ethanol); glycols (including propylene glycol, dipropylene glycol, tripropylene glycol and mixtures thereof); glycerides (including mono-, di- and triglycerides); medium to long chain organic acids, alcohols and esters; surfactants (including emulsifying and dispersing agents); additional amino acids; structurants (including thickeners and gelling agents, for example polymers, silicates and silicon dioxide); emollients; fragrances; and colorants (including dyes and pigments).
• water-soluble alcohols such as C 2 _8 alcohols including ethanol
• glycols including propylene glycol, dipropylene glycol, tripropylene glycol and mixtures thereof
• glycerides including mono-, di- and triglycerides
• medium to long chain organic acids, alcohols and esters surfactants (including
• composition 2 2.1, or 2.2 wherein the composition is in the form of an aerosol anti perspirant spray .
• a method for controlling perspiration comprising mixing both components and applying to skin an antiperspirant effective amount of a formulation of any embodiment embraced or specifically described herein, e.g., any of Composition 2, et seq.: and (ii) a method for controlling odor from perspiration or bacteria on the skin, comprising mixing both components and applying to skin a deodorant effective amount of a formulation of any embodiment embraced or specifically described herein, e.g., any of Composition 2, el seq.
• an antiperspirant or deodorant comprising (i) a first component comprising a tetrabasic zinc halide and (ii) a second component physical ly separate from the first component comprising cysteine in free or cosmetically acceptable salt form, e.g., any of Composition 2, et seq. comprising combining a cosmetically acceptable carrier, and optionally glycerol, with zinc amino acid halide in the first component, and/or with cysteine in the second component.
• a cosmetically acceptable carrier e.g., any of Composition 2, et seq.
• cysteine in the manufacture of an antiperspirant or deodorant formulation, e.g., a formulation according to any of Composition 2, et seq.
• the tetrabasic zinc -amino acid halide and cysteine in free or cosmetically acceptable salt form can be incorporated into a suitable, cosmetically acceptable base, for example a spray, aerosol, stick, or roll-on for application to the underarm wherein the first and second components mix when forming an aerosol or when contacted through a nozzle or other dispensing means.
• a suitable, cosmetically acceptable base for example a spray, aerosol, stick, or roll-on
• the salt will flocculate, forming plugs which block sweat release. Additional water from sweat ca moreover dilute the formulation, causing the complex to decompose, resulting in a precipitate composed primarily of zinc oxide in complex with cysteine, which can reduce sweat and odor as described above.
• antiperspirant can refer generally to any product that can form a plug in a pore to reduce sweating, including those materials classified as antiperspirants by the Food and Drug Administration under 21 CFR part 350. it is understood that antiperspirants may also be deodorants, particularly in the case of the described compositions, as zinc has antibacterial properties and thus inhibits odor-causing bacteria on the skin.
• composition 3 which is a personal care product selected from liquid hand soap, body wash, dermal lotions, dermal creams, and dermal conditioners comprising (i) a first component comprising a tetrabasic zinc-amino acid or TAG-halide complex and (ii) a second component comprising acidified cysteine in free or in orally or cosmetically acceptable salt form, wherein the two components are maintained separate from each other until dispensed and combined for application to the body, and wherein either or both components additionally comprise a cosmetically acceptable carrier, e.g. in accordance with any of the scopes of Composition 1 , et seq., e.g.:
• Composition 3 which, upon mixture of both components and use , provides a precipitate to the skin, comprising zinc oxide in complex with cysteine, and optionally additionally comprising zinc oxide, zinc carbonate, and mixtures thereof.
• Composition 3 or 3.1 comprising the tetrabasic zinc halide complex in an amount of 1 to 10 % by weight of the total composition.
• any of the foregoing compositions, wherein a total amount of zinc present in the total composition is 0.1 to 8 weight %, or 0.1 to 2 or 0.1 to 1 weight %.
• cysteine is a cysteine hydrohalide, optionally cysteine hydrochloride.
• compositions wherein the cosmetically acceptable carrier comprises one or more ingredients selected from water-soluble alcohols (such as C 2 _s alcohols including ethanol); glycols (including propylene glycol, dipropylene glycol, tripropyieiie glycol and mixtures thereof); glycerides (including mono-, di- and triglycerides); medium to long chain organic acids, alcohols and esters; surfactants (including emulsifying and dispersing agents); additional amino acids; strttcturants (including thickeners and gelling agents, for example polymers, silicates and silicon dioxide); emollients; fragrances; and colorants (including dyes and pigments).
• water-soluble alcohols such as C 2 _s alcohols including ethanol
• glycols including propylene glycol, dipropylene glycol, tripropyieiie glycol and mixtures thereof
• glycerides including mono-, di- and triglycerides
• the cosmetically acceptable carrier comprises one or more nonionic surfactants, for example non-ionic surfactants selected from amine oxide surfactants (e.g., fatty acid amides of alkyl amines, for example lauramidopropyldimethylamine oxide, myristamidopropylamine oxide and mixtures thereof), alcohol amide surfactants (e.g., fatty acid amides of alcohol amines, e.g., cocamide EA (cocomonoethanoiamide)), polyethoxyiated surfactants (e.g.
• amine oxide surfactants e.g., fatty acid amides of alkyl amines, for example lauramidopropyldimethylamine oxide, myristamidopropylamine oxide and mixtures thereof
• alcohol amide surfactants e.g., fatty acid amides of alcohol amines, e.g., cocamide EA (cocomonoethanoiamide)
• polyethoxyiated derivatives of esters of fatty acids and poiyois for example glycols, glycerols, saccharides or sugar alcohols), for example poiysorbates or PEG- 120 methyl glucose dio!eate, and combinations thereof.
• compositions wherein the cosmetically acceptable carrier comprises an anionic surfactant, e.g. selected from, sodium lauryl sulfate and sodium ether laury! sulfate.
• anionic surfactant e.g. selected from, sodium lauryl sulfate and sodium ether laury! sulfate.
• compositions wherein the cosmetically acceptable carrier comprises water, an anionic surfactant, e.g., sodium laureth sulfate, a viscosity modifying agent, e.g., acrylates copolymer, and a zwitterionic surfactant, e.g., cocamidopropyl betaine.
• an anionic surfactant e.g., sodium laureth sulfate
• a viscosity modifying agent e.g., acrylates copolymer
• a zwitterionic surfactant e.g., cocamidopropyl betaine.
• the cosmetically acceptable carrier comprises water, quaternary ammonium agents (e.g. cetrimonium chloride), humectant (e.g. glycerin), and non-ionic surfactant (e.g., selected from amine oxide surfactants (e.g., lauramidopropyldimethyiamine oxide myristamidopropylamine oxide and mixtures thereof), alcohol amide surfactants (e.g., cocamide M EA (cocomonoethanolarnide)), polyethoxylate surfactants (e.g. PEG- 120 methyl glucose dioleate), and combinations thereof).
• quaternary ammonium agents e.g. cetrimonium chloride
• humectant e.g. glycerin
• non-ionic surfactant e.g., selected from amine oxide surfactants (e.g., lauramidopropyldimethyiamine oxide myristamidopropylamine oxide and mixtures
• the cosmetically acceptable carrier comprises an antibacterially effective amount of a non-zinc antibacterial agent, e.g., an antibacterial agent selected from triclosan, triclocarban, chloroxylenol, herbal extracts and essential oils (e.g.
• CPC cetylpyridinium chloride
• TPC benzalkon
• compositions comprising ingredients as follows:
• the formulation is in a container that has a divided chamber; one chamber containing the above base with cysteine and the other containing the above base with TBZC-lys.
• Also provided are methods of killing bacteria comprising mixing both components and contacting the bacteria with an antibacterially effective amount of the mixture, e.g., with any of Composition 3, et seq, for example, methods of treating or reducing the incidence of topical skin infections, for example infections by Staphylococcus aureus and/or Streptococcus pyogenes, as well as to treat or reduce the incidence of acne, comprising washing the skin with an antibacterially effective amount of a TBZH-AA or TBZH-TAG and cysteine, e.g., with any of Composition 3, et seq., and w r ater.
• a method of making a personal care comprising (i) a first component comprising a tetrabasic zinc-amino acid halide and (ii) a second component physically separate from the first component comprising cysteine in free or cosmetically acceptable salt form, e.g., any of Composition 3, et seq. comprising combining a cosmetically acceptable carrier, and optionally glycerol, with tetra basic zinc amino acid halide in the first component, and/or with cysteine in the second component.
• a cosmetically acceptable salt form e.g., any of Composition 3, et seq.
• a dual component composition containing TBZH-AA or TBZH-TAG complex and cysteine e.g., any of Compositions 1, et seq., to kill bacteria, to protect the skin, e.g., from bacteria or to provide a visual signal when washing
• a TBZH-AA or TBZH-TAG and cysteine in the manufacture of a composition, any of Compositions 1 , et seq., to kill bacteria, to protect the skin, or to provide a visual signal when washing
• TBZH-AA or TBZH-TAG and cysteine e.g., any of Compositions 1, et seq, for use to kill bacteria, to protect the skin, or to provide a visual signal when washing.
• either the first component comprising the tetrabasic zinc halide- amino acid complex or the second component comprising the cysteine, or both are mixed with conventional commercial liquid hand soap formulation ingredients comprising surfactants and optionally benzalkoniimi chloride.
• conventional commercial liquid hand soap formulation ingredients comprising surfactants and optionally benzalkoniimi chloride.
• a white precipitate is instantaneously formed.
• the composition of the invention can provide a visual/sensory trigger for the washing process.
• the precipitate, composed of ZnO stabilized by cysteine, is deposited on skin and thus enhances the antimicrobial effect of the LHS.
• composition which is an oral care product, e.g., a dentifrice or mouthrmse, comprising (i) a first component comprising a tetrabasic zinc-amino acid or TAG-halide complex and (ii) a second component comprising acidified cysteine in free or in orally or cosmetically acceptable salt form, wherein the two components are maintained separate from each other until dispensed and combined for application to the oral cavity, and wherein either or both components additionally comprise an orally acceptable carrier, e.g. in accordance with any of the scopes of Composition 1, et seq., e.g.:
• Composition 4 in the form of a dentifrice which upon mixing and application to the teeth provides a precipitate to the teeth, comprising zinc oxide in complex with cysteine, and optionally additionally comprising zinc oxide, zinc carbonate, and mixtures thereof.
• Composition 4 or 4.1 in the form of a dentifrice wherein the tetrabasic zinc- amino acid halide complex is present in an effective amount, e.g., in an amount of 0.5-4% by weight of zinc, e.g., 1 -3% by weight of zinc of the total composition, and wherein the orally acceptable carrier is a dentifrice base.
• compositions 4-4.3 in the form of a dentifrice, wherein the orally acceptable carrier is a dentifrice base comprising an abrasive, e.g., an effective amount of a silica abrasive, e.g., 10-30%, e.g., 20%.
• abrasive e.g., an effective amount of a silica abrasive, e.g., 10-30%, e.g., 20%.
• tetrabasic zinc amino acid halide complex is present in an effective amount, e.g., in an amount of 0.1 -3% by weight of zinc, e.g., 0.2-1% by weight of zinc of the total composition.
• cysteine is a cysteine hydrohalide, optionally cysteine hydrochloride.
• compositions further comprising an effective amount of a fluoride ion source, e.g., providing 500 to 3000 ppm fluoride based on the total composition.
• a fluoride ion source e.g., providing 500 to 3000 ppm fluoride based on the total composition.
• any of the foregoing compositions further comprising an effective amount of fluoride, e.g., wherem the fluoride is a salt selected from stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride (e.g., N'-octadecyltrimethylendiamme-N,N,N'- tris(2- ethanol)-dihydrofluoride), ammonium fluoride, titanium fluoride, hexafluorosulfate, and combinations thereof.
• the fluoride is a salt selected from stannous fluor
• compositions comprising an effective amount of one or more alkali phosphate salts, e.g., sodium, potassium or calcium salts, e.g., selected from alkali dibasic phosphate and alkali pyrophosphate salts, e.g., alkali phosphate salts selected from sodium phosphate dibasic, potassium phosphate dibasic, dicalcium phosphate dih drate, calcium pyrophosphate, tetrasodium pyrophosphate, tetrapotassiura pyrophosphate, sodium tripolyphosphate, and mixtures of any of two or more of these, e.g., in an amount of 1-20%, e.g., 2-8%, e.g., ca. 5%, by weight of the composition.
• alkali phosphate salts e.g., sodium, potassium or calcium salts
• alkali phosphate salts selected from sodium phosphate dibasic, potassium phosphate dibasic, dicalcium
• compositions comprising buffering agents, e.g., sodium phosphate buffer (e.g., sodium phosphate monobasic and disodium phosphate).
• buffering agents e.g., sodium phosphate buffer (e.g., sodium phosphate monobasic and disodium phosphate).
• compositions comprising a humectant, e.g., selected from sorbitol, propylene glycol, polyethylene glycol, xylitol, and mixtures thereof.
• a surfactant e.g., selected from anionic, cationic, zwitterionic, and nonionic surfactants, and mixtures thereof, e.g., comprising an anionic surfactant, e.g., a surfactant selected from sodium lauryl sulfate, sodium ether lauryl sulfate, and mixtures thereof, e.g. in an amount of from 0.3% to 4.5% by weight, e.g.
• SLS sodium lauryl sulfate
• a zwitterionic surfactant for example a betaine surfactant, for example cocamidopropylbetaine, e.g. in an amount of from 0.1% to 4.5% by weight of the total composition, e.g. 0.5-2% cocamidopropylbetaine.
• a viscosity modifying amount of one or more of polysaccharide gums for example xanthan gum or carrageenan, silica thickener, and combinations thereof,
• compositions further comprising flavoring, fragrance and/or coloring.
• compositions comprising an effective amount of one or more antibacterial agents, for example comprising an antibacterial agent selected from halogenated diphenyl ether (e.g. triclosan), herbal extracts and essential oils (e.g., rosemary extract, tea extract, magnolia extract, thymol, menthol, eucalyptol, geraniol, carvaerol, citral, hinokitol, catechol, methyl salicylate, epigallocatechin gallate, epigaliocatechin, gallic acid, miswak extract, sea-buckthorn extract), bisguanide antiseptics (e.g., chlorhexidine, alexidine or octenidine), quaternary ammonium compounds (e.g., cetylpyridinium chloride (CPC), benzalkonium chloride, tetradecylpyridiniimi chloride (TPC), -tetradecyl-4-ethylpyridinium chloride (T)
• compositions comprising an antibacterially effective amount of triclosan, e.g. 0.1 -0.5%, e.g. 0.3% by weight of the total composition.
• compositions further comprising a whitening agent, e.g., a selected from the group consisting of peroxides, metal chlorites, perborates, percarbonates, peroxyacids, hypochlorites, and combinations thereof.
• a whitening agent e.g., a selected from the group consisting of peroxides, metal chlorites, perborates, percarbonates, peroxyacids, hypochlorites, and combinations thereof.
• compositions further comprising hydrogen peroxide or a hydrogen peroxide source, e.g., urea peroxide or a peroxide salt or complex (e.g., such as peroxyphosphate, peroxycarbonate, perborate, peroxysilicate, or persulphate salts; for example calcium peroxyphosphate, sodium perborate, sodium carbonate peroxide, sodium peroxyphosphate, and potassium persulfate);
• hydrogen peroxide or a hydrogen peroxide source e.g., urea peroxide or a peroxide salt or complex (e.g., such as peroxyphosphate, peroxycarbonate, perborate, peroxysilicate, or persulphate salts; for example calcium peroxyphosphate, sodium perborate, sodium carbonate peroxide, sodium peroxyphosphate, and potassium persulfate);
• compositions further comprising an agent that interferes with or prevents bacterial attachment, e.g., solbrol or chitosaii.
• compositions further comprising a source of calcium and phosphate selected from (i) calcium-glass complexes, e.g., calcium sodium phosphosilicates, and (ii) calcium-protein complexes, e.g., casein phosphopeptide-amorphous calcium phosphate
• a source of calcium and phosphate selected from (i) calcium-glass complexes, e.g., calcium sodium phosphosilicates, and (ii) calcium-protein complexes, e.g., casein phosphopeptide-amorphous calcium phosphate
• a soluble calcium salt e.g., selected from calcium sulfate, calcium chloride, calcium nitrate, calcium acetate, calcium lactate, and combinations thereof.
• compositions further comprising a physiologically or orally acceptable potassium salt, e.g., potassium nitrate or potassium chloride, in an amount effective to reduce dentinal sensitivity.
• a physiologically or orally acceptable potassium salt e.g., potassium nitrate or potassium chloride
• compositions further comprising an anionic polymer, e.g., a synthetic anionic polymeric polycarboxylate, e.g., wherein the anionic polymer is selected from 1 :4 to 4: 1 copolymers of maleic anhydride or acid with another polymerizable ethylenically unsaturated monomer; e.g., wherein the anionic polymer is a methyl vinyl ether/maleic anhydride (PVM/MA) copolymer having an average molecular weight (M.W.) of 30,000 to 1,000,000, e.g. 300,000 to 800,000, e.g., wherein the anionic polymer is 1-5%, e.g., 2%, of the weight of the total composition.
• an anionic polymer e.g., a synthetic anionic polymeric polycarboxylate, e.g., wherein the anionic polymer is selected from 1 :4 to 4: 1 copolymers of maleic anhydride or acid with another poly
• compositions further comprising a breath freshener, fragrance or flavoring.
• compositions in the form of an oral gel wherein the amino acid is lysine and the halide is chloride, in an amount to provide 0.1 - 8%, e.g., 0.5% zinc by weight, and further comprising humectant, e.g., sorbitol, propylene glycol and mixtures thereof, e.g., in an amount of 45-65%, e.g., 50-60%, thickeners, e.g., cellulose derivatives, e.g., selected from carboxymethyl cellulose (CMC), trimethyl cellulose (TMC) and mixtures thereof, e.g., in an amount of 0.1-2%, sweetener and/or flavorings, and water, e.g., an oral gel comprising Ingredients %
• Cysteine 0.02 - 0.5% e.g., 0.1%
• CMC Carboxymethyl cellulose
• TMC Trimethyl. cellulose
• Flavoring and/or sweetener 0.01-1%
• the formulation is in a tube that has a dual chamber system that separates one side from the other; or, the system has a high enough density difference that allows for almost complete separation of the two stocks or components.
• the dentifrice of the invention can be placed in a dual chamber tube, each chamber containing one of the respective components.
• Each component can contain a dentifrice base, e.g., a gel base, as well as either cysteine or TBZH-AA or TBZH-TAG.
• a dentifrice base e.g., a gel base
• cysteine or TBZH-AA or TBZH-TAG e.g., cysteine or TBZH-AA or TBZH-TAG.
• Also provided are methods to reduce and inhibit acid erosion of the enamel, clean the teeth, reduce bacterially-generated biofilm and plaque, reduce gingivitis, inhibit tooth decay and formation of cavities, and reduce dentinal hypersensitivity comprising mixing both components and applying an effective amount of a composition, e.g., any of Composition 4, et seq, to the teeth, and optionally then rinsing with water or aqueous solution sufficient to enhance precipitation of zinc oxide in complex with cysteine from the composition.
• a composition e.g., any of Composition 4, et seq
• a method of making a an oral care product comprising (i) a first component comprising a tetrabasic zinc-ammo acid halide and (ii) a second component physically separate from the first component comprising cysteine in free or cosmetically acceptable salt form, e.g., any of Composition 4, et seq. comprising combining an orally acceptable carrier, and optionally glycerol, with zinc amino acid halide in the first component, and/or with cysteine in the second component.
• a first component comprising a tetrabasic zinc-ammo acid halide
• a second component physically separate from the first component comprising cysteine in free or cosmetically acceptable salt form, e.g., any of Composition 4, et seq. comprising combining an orally acceptable carrier, and optionally glycerol, with zinc amino acid halide in the first component, and/or with cysteine in the second component.
• QLF quantitative light-induced fluorescence
• a TBZH-AA or TBZH-TAG complex and (ii) cysteine in free or orally acceptable salt form, to reduce and inhibit acid erosion of the enamel, clean the teeth, reduce bacteriaily-generated biofilm and plaque, reduce gingivitis, inhibit tooth decay and formation of cavities, and/or reduce dentinal hypersensitivity,
• the TBZH-AA or TBZH-TAG complex is prepared at room temperature by mixing the precursors in an aqueous solution.
• the in situ formation provides ease of formulation.
• the precursors can be used instead of first having to form the salt.
• the water pemntting formation of the salt from the precursor comes from water (e.g., rinsing water, saliva or sweat, depending on the application) that comes into contact with the composition in the course of use.
• the total amount of zinc in the composition is 0.05 to 8 % by weight of the total composition. In other embodiments, the total amount of zinc is at least 0.1, at least 0.2, at least 0.3, at least 0.4, at least 0.5, or at least 1 up to 8% by weight of the total composition. In other embodiments, the total amount of zinc in the composition is less than 5, less than 4, less than 3, less than 2, or less than 1 to 0.05% by weight of the total composition. For example, the zinc content may be 2-3%.
• the TBZH-AA or TBZH-TAG complex is anhydrous for dentrifice compositions that contain less than 10% water by weight.
• anhydrous there is less than 5% by weight water, optionally less than 4, less than 3, less than 2, less than 1, less than 0.5, less than 0.1 down to 0% by weight water.
• precursors of tetrabasic zinc amino acid haiide complex e.g., TBZC and lysine hydrochloride, will not significantly react.
• the precursors When contacted with a sufficient amount of water, the precursors will then react to form the desired salt which upon further dilution with use forms the desired precipitate on the skin or teeth.
• the amino acid in the TBZH-AA complex can a basic amino acid.
• basic amino acid is meant the naturally occurring basic amino acids, such as arginine, lysine, and histidine, as well as any basic amino acid having a carboxyl group and an amino group in the molecule, which is water-soluble and provides an aqueous solution with a pH of 7 or greater.
• basic amino acids include, but are not limited to, arginine, lysine, citruliine, ornithine, creatine, histidine, diaminobutanoic acid, diaminoproprionic acid, salts thereof or combinations thereof.
• the basic amino acid is lysine.
• the basic amino acids for use in making zinc amino acid haiide complex are generally provided in the form of the haiide acid addition salt, e.g., a hydrochloride.
• the compositions also comprise cysteine in free or orally or cosmetically acceptable salt form.
• cysteine in free or orally or cosmetically acceptable salt form.
• orally or cosmetically acceptable salt form is meant a salt form which is safe for administration to the oral cavity or skin respectively in the concentrations provided, and which does not interfere with the biological activity of the zinc.
• the cysteine is administered in free form.
• weights are given for amounts of amino acids in formulations herein, the weights are generally provided in terms of the weight of the free acid unless otherwise noted.
• the optional ingredients described herein can be present in the first component, the second component or both.
• Glycerol or glycerin is an optional ingredient in the first and/or second component of the composition. It has found that the presence of glycerol can delay the precipitation of the TBZH- AA complex when the two components are mixed. Glycerol can also act as a humectant.
• compositions also comprise cysteine in free or orally or cosmetically acceptable salt form.
• cysteine in free or orally or cosmetically acceptable salt form.
• orally or cosmetically acceptable salt form is meant a salt form which is safe for administration to the oral cavity or skin respectively in the concentrations provided, and which does not interfere with the biological activity of the zinc.
• the cysteine is administered in free form.
• the weights are generally provided in terms of the weight of the free acid unless otherwise noted.
• the cysteine is a cysteine hydrohalide, such as cysteine hydrochloride.
• compositions comprising an orally or cosmetically acceptable carrier
• the carrier represents all other materials in the composition other than TBZH-AA or TBZH-TAG complex (including precursors) and the cysteine.
• the amount of carrier is thus the amount to reach 100% by adding to the weight of TBZH-AA or TBZH-TAG complex (including precursors) and the protein.
• Orally acceptable carrier is meant a carrier which is suitable for use in an oral care product, consisting of ingredients which are generally recognized as safe for use in amounts and concentrations as provided in a dentifrice or mouthrinse, for example.
• cosmetically acceptable carrier is meant a carrier which is suitable for use in a product for topical use on the skin, consisting of ingredients which are generally recognized as safe for use in amounts and concentrations as provided in a liquid hand soap or body wash, or in an antiperspirant product, for example.
• Excipients for use in the compositions thus may include for example excipients which are "Generally Recognized as Safe” (GRAS) by the United States Food and Dr g Administration.
• GRAS Generally Recognized as Safe
• compositions or carrier medium that provides the appropriate deliver ⁇ ? of an effective amount of the complex as defined herein, does not interfere with the effectiveness of the biological activity of the zinc, and is suitable and nontoxic for topical administration to the skin.
• Representative carriers include water, oils, both vegetable and mineral, soap bases, cream bases, lotion bases, ointment bases and the like, particularly aqueous detergent carriers, for example liquid hand soaps or body washes.
• the aqueous soap bases are free of or contain less than one percent of anionic surfactants.
• the cosmetically acceptable earlier contains topically acceptable quaternary ammonium compounds.
• Additives for topical formulations are well-known in the art, and may be added to the topical composition, as long as they are pharmaceutically acceptable and not deleterious to the epithelial cells or their function. Further, they should not cause deterioration in the stability of the composition.
• inert fillers for example, inert fillers, anti-irritants, tackifiers, excipients, fragrances, opacifiers, antioxidants, gelling agents, stabilizers, surfactant, emollients, coloring agents, preservatives, buffering agents, and other conventional components of topical formulations as are known in the art.
• the personal care compositions comprise oils or moisturizers, which may not be water soluble and may be delivered in an emulsion system, wherein the zinc-lysine complex would be in the water phase of the emulsion.
• Surfactants for the emulsion formulations may comprise a combination of nonionic surfactants, for example, one or more surfactants selected from the group consisting of: (i) lipophilic surfactants, e.g., having an HLB value of 8 or lower, for example sorbitan-fatty acid esters, such as sorbitan oleates, for example, sorbitan sesquioleate; and (ii) hydrophilic surfactants, e.g., having an HLB of greater than 8, particularly a.
• di- or tri-alkanol amines such as triethanol amine
• polyethoxylated surfactants for example polyethoxylated alcohols (esp. polyethoxylated polyols), polyethoxylated vegetable oils, and polyethoxylated silicones, e.g., polysorbate 80, dimethicone polyethylene oxide, and dimethylmethyl (polyethylene oxide) siloxane.
• the overall HLB of the surfactant mixture is preferably 2-8, i.e., there is typically a higher proportion of lipophilic surfactant; whereas for an oil-in-water emulsion, the overall HLB of the surfactant mixture is preferably 8-16.
• the personal care compositions may also comprise suitable antioxidants, substances known to inhibit oxidation.
• Antioxidants suitable for use in the compositions include, but are not limited to, butylated hydroxytoluene, ascorbic acid, sodium ascorbate, calcium ascorbate, ascorbic palmitate, butylated hydroxy anisole, 2,4,5- trihydroxybutyrophenone, 4- hydiOxymetIiyl-2,6-di-fert-butyIphenoI, erythorbic acid, gum guaiac, propyl gallate, thiodipropionic acid, dilauryl thiodipropionate, tert-butylhydroquinone and tocopherols such as vitamin E, and the like, including pharmaceutically acceptable salts and esters of these compounds.
• the antioxidant is butylated hydroxytoluene, butylated hydroxyanisole, propyl gallate, ascorbic acid, pharmaceutically acceptable salts or esters thereof or mixtures thereof.
• the antioxidant is butylated hydroxytofuene. These materials are available from Ruger Chemical Co, (Irvington, NJ), When the topical formulations contain at least one antioxidant, the total amount of antioxidant present is from 0.001 to 0.5 wt%, preferably 0.05 to 0.5 wt%, more preferably 0.1%.
• the pesonal care compositions may also comprise suitable preservatives.
• Preservatives are compounds added to a formulation to act as an antimicrobial agent.
• preservatives known in the art. as being effective and acceptable in parenteral formulations are benzalkonium chloride, benzethonium, chlorohexidine, phenol, m-cresol, benzyl alcohol, methylparaben, propylparaben, chlorobutanol, o-cresol, p-cresol, chiorocresol, phenylmercuric nitrate, thimerosal, benzoic acid, and various mixtures thereof. See, e.g., Walfrier, K.-H,, Develop. Biol.
• the preservative is selected from methylparaben, propylparaben and mixtures thereof. These materials are available from Inolex Chemical Co (Philadelphia, PA) or Spectrum Chemicals.
• the topical formulations contain at least one preservative, the total amount of preservative present is from 0.01 to 0.5 wt%, preferably from 0.1 to 0.5%, more preferably from 0.03 to 0.15.
• the preservative is a mixture of methylparaben and proplybarben in a 5/1 ratio. When alcohol is used as a preservative, the amount is usually 15 to 20%.
• the personal care compositions may also comprise suitable chelating agents to form complexes with metal cations that do not cross a lipid bilayer.
• suitable chelating agents include ethylene diamine tetraacetic acid (EDTA), ethylene glycol-bis(beta- aminoethyl ether)- ,N,N', N' -tetraacetic acid (EGTA) and 8-Amino-2-[(2-amino-5- methylphenoxy)methyl]-6-methoxyqumoiine-N 5 N,N , ,N'-tetraacetic acid, tetrapotassium salt (QUIN-2).
• the chelating agents are EDTA. and citric acid.
• the topical formulations contain at least one chelating agent
• the total amount of chelating agent present is from 0.005% to 2.0% by weight, preferably from 0.05% to 0.5 wt%, more preferably 0.1 % by weight. Care must be taken that the chelators do not interfere with the zinc complex, for example by binding zinc, but in the formulations tested, low levels of EDTA, for example, have not presented problems.
• the personal care compositions may also comprise suitable viscosity increasing agents. These components are diffusible compounds capable of increasing the viscosity of a polymer- containing solution through the interaction of the agent with the polymer.
• CARBOPOL ULTREZ 10 may be used as a viscosity-increasing agent. These materials are available from Noveon Chemicals, Cleveland, OH. When the topical formulations contain at least one viscosity increasing agent, the total amount of viscosity increasing agent present is from 0.25% to 5.0% by weight, preferably from 0.25% to 1.0 wt%, and more preferably from 0.4% to 0.6% by weight.
• Liquid forms such as lotions suitable for topical administration or suitable for cosmetic application, may include a suitable aqueous or nonaqueous vehicle with buffers, suspending and dispensing agents, thickeners, penetration enhancers, and the like.
• Solid forms such as creams or pastes or the like may include, for example, any of the following ingredients, water, oil, alcohol or grease as a substrate with surfactant, polymers such as polyethylene glycol, thickeners, solids and the like.
• Liquid or solid formulations may include enhanced delivery technologies such as liposomes, microsomes, microsponges and the like.
• Topical treatment regimens can comprise applying the composition directly to the skin at the application site, from one to several times daily, and washing with water to trigger precipitation of the zinc oxide on the skin.
• Formulations can be used to treat, ameliorate or prevent conditions or symptoms associated with bacterial infections, acne, inflammation and the like.
• the oral care compositions may comprise various agents which are active to protect and enhance the strength and integrity of the enamel and tooth structure and/or to reduce bacteria and associated tooth decay and/or gum disease, including or in addition to the zine-amino acid-halide complexes.
• Effective concentration of the active ingredients used herein will, depend on the particular agent and the delivery system used. It is understood that a toothpaste for example will typically be diluted with water upon use, while a mouthrinse typically will not be. Thus, an effective concentration of active in a toothpaste will ordinarily be 5-15x higher than required for a mouthrinse. The concentration will also depend on the exact salt or polymer selected.
• the counterion will affect the weight of the salt, so that if the counterion is heavier, more salt by weight will be required to provide the same concentration of active ion in the final product.
• Argmine where present, may be present at levels from, e.g., 0.1 to 20 wt % (expressed as weight of free base), e.g., 1 to 10 wt % for a consumer toothpaste or 7 to 20 wt % for a professional or prescription treatment product.
• Fluoride where present may be present at levels of, e.g., 25 to 25,000 ppm, for example 750 to 2,000 ppm for a consumer toothpaste, or 2,000 to 25,000 ppm for a professional or prescription treatment product.
• Levels of antibacterial agents will vary similarly, with levels used in toothpaste being e.g., 5 to 15 times greater than used in mouthrinse.
• a triclosan toothpaste may contain 0.3 wt % triclosan.
• the oral care compositions may further include one or more fluoride ion sources, e.g., soluble fluoride salts.
• fluoride ion sources e.g., soluble fluoride salts.
• fluoride ion-yielding materials can be employed as sources of soluble fluoride in the present compositions. Examples of suitable fluoride ion- yielding materials are found in U.S. Pat. No. 3,535,421, to Briner et al.; U.S. Pat. No. 4,885,155, to Parran, Jr. et al. and U.S. Pat. No. 3,678,154, to Widder et al.
• Representative fluoride ion sources include, but are not limited to, stannous fluoride, sodium fluoride, potassium fluoride, sodium monofl orophosphate, sodium fiuorosilicate, ammonium fiuorosilicate, amine fluoride, ammonium fluoride, and combinations thereof.
• the fluoride ion source includes stannous fluoride, sodium fluoride, sodium monofluorophosphate as well as mixtures thereof.
• the oral care composition may also contain a source of fluoride ions or fluorine-providing ingredient in amounts sufficient to supply 25 ppm to 25,000 ppm of fluoride ions, generally at least 500 ppm, e.g., 500 to 2000 ppm, e.g., 1000 to 1600 ppm, e.g., 1450 ppm.
• the appropriate level of fluoride will depend on the particular application.
• a toothpaste for general consumer use would typically have 1000 to 1500 ppm, with pediatric toothpaste having somewhat less.
• a dentifrice or coating for professional application could have as much as 5,000 or even 25,000 ppm fluoride.
• Fluoride ion sources may be added to the compositions at a level of 0.01 wt.
• Weights of fluoride salts to provide the appropriate level of fluoride ion will obviously vary based on the weight of the counterion in the salt.
• the oral care compositions may include silica abrasives, and may comprise additional abrasives, e.g., a calcium phosphate abrasive, e.g., tricalcium phosphate ⁇ ' ⁇ : ). ⁇ ).
• additional abrasives e.g., a calcium phosphate abrasive, e.g., tricalcium phosphate ⁇ ' ⁇ : ). ⁇ ).
• hydroxyapatite Ca 1 o(P0 4 )6(OH) 2
• dicalcium phosphate dihydrate CaHP0 4 ⁇ 2H?0, also sometimes referred to herein as DiCal
• calcium pyrophosphate calcium carbonate abrasive
• abrasives such as sodium metaphosphate, potassium metaphosphate, aluminum silicate, calcined alumina, bentomte or other siliceous materials, or combinations thereof.
• silica abrasive polishing materials useful herein, as well as the other abrasives generally have an average particle size ranging between 0.1 and 30 microns, between 5 and 15 microns.
• the silica abrasives can be from precipitated silica or silica gels, such as the silica xerogels described in U.S. Pat. No. 3,538,230, to Pader et al. and U.S. Pat. No. 3,862,307, to Digiulio.
• Particular silica xerogels are marketed under the trade name Syloid® by the W. R. Grace & Co., Davison Chemical Division.
• the precipitated silica materials include those marketed by the J. M.
• abrasive materials useful in the practice of the oral care compositions include silica gels and precipitated amorphous silica having an oil absorption value of less than 100 cc/100 g silica and in the range of 45 cc/100 g to 70 cc/100 g silica. Oil absorption values are measured using the AST A Rub-Out Method D281.
• the silicas are colloidal particles having an average particle size of 3 microns to 12 microns, and 5 to 10 microns.
• Low oil absorption silica abrasives particularly useful in the compositions are marketed under the trade designation Sylodent XWA® by Davison Chemical Division of W.R. Grace & Co., Baltimore, Md. 21203.
• Sylodent 650 XWA® a silica hydrogel composed of particles of colloidal silica having a water content of 29% by weight averaging 7 to 10 microns in diameter, and an oil absorption of less than 70 cc/100 g of silica is an example of a low oil absorption silica abrasive useful in the composition.
• the oral care compositions also may include an agent to increase the amount of foam that is produced when the oral cavity is brushed.
• agents that increase the amount of foam include, but are not limited to polyoxyethylene and certain polymers including, but not limited to, alginate polymers.
• the polyoxyethylene may increase the amount of foam and the thickness of the foam generated by the oral care carrier component of the composition.
• Polyoxyethylene is also commonly known as polyethylene glycol (“PEG”) or polyethylene oxide.
• PEG polyethylene glycol
• the polyoxyethylenes suitable for this composition will have a molecular weight of 200,000 to 7,000,000. in one embodiment the molecular weight will be 600,000 to 2,000,000 and in another embodiment 800,000 to 1,000,000.
• Polyox® is the trade name for the high molecular weight polyoxyethylene produced by Union Carbide.
• the polyoxyethylene may be present in an amount of 1% to 90%, in one embodiment 5% to 50% and in another embodiment 10% to 20% by weight of the oral care carrier component of the oral care compositions.
• the amount of foaming agent in the oral care composition i.e., a single dose
• the amount of foaming agent in the oral care composition is 0.01 to 0.9 % by weight, 0.05 to 0.5% by weight, and in another embodiment 0.1 to 0.2 % by weight.
• compositions may contain anionic, cationic, nonionic and/or zwitterionic surfactants, for example:
• water-soluble salts of higher fatty acid monoglyceri.de monosulfates such as the sodium salt of the monosulfated monoglyceride of hydrogenated coconut oil fatty acids such as sodium N-methyl N-cocoyl taurate, sodium cocomonoglyceri.de sulfate,
• alkyl sulfates such as sodium lauryl sulfate
• alkyl-ether sulfates e.g., of formula CH3(CH2) m CH 2 (OCH 2 CH2) confrontOS0 X, wherein m is 6-16, e.g., 10, n is 1-6, e.g., 2, 3 or 4, and X is Na or , for example sodium laureth- 2 sulfate
• alkyl and sulfonates such as sodium dodecyl benzene sulfonate (sodium lauryl benzene sulfonate)
• higher alkyl sulfoacetates such as sodium lauryl sulfoacetate (dodecyl sodium sulfoacetate), higher fatty acid esters of 1 ,2 dihydroxy propane sulfonate, suifocolaurate (N-2-ethyl laurate potassium sulfoacetamide) and sodium lauryl sarcosinate.
• the anionic surfactant is selected from sodium lauryl sulfate and sodium ether lauryl sulfate.
• the anionic surfactant may be present in an amount which is effective, e.g., > 0.01 % by weight of the formulation, but not at a concentration which would be irritating to the oral tissue, e.g., ⁇ 10%, and optimal concentrations depend on the particular formulation and the particular surfactant. For example, concentrations used or a mouthwash are typically on the order of one tenth that used for a toothpaste.
• the anionic surfactant is present in a toothpaste at 0.3% to 4.5% by weight, e.g., 1 .5%.
• the compositions may optional ly contain mixtures of surfactants, e.g., comprising anionic surfactants and other surfactants that may be anionic, cationic, zwitterionic or nonionic.
• surfactants are those which are reasonably stable throughout a wide pH range. Surfactants are described more fully, for example, in U.S. Pat, No. 3,959,458, to Agricola et al.; U.S. Pat. No. 3,937,807, to Haefele; and U.S. Pat. No. 4,051,234, to Gieske et al.
• the anionic surfactants useful herein include the water- soluble salts of alkyl sulfates having 10 to 18 carbon atoms in the alky I radical and the water- soluble salts of sulfonated monoglycerides of fatty acids having 10 to 18 carbon atoms.
• Sodium lauryl sulfate, sodium lauroyl sarcosinate and sodium coconut monoglyceride sulfonates are examples of anionic surfactants of this type.
• the composition e.g., Composition 4, et seq., comprises sodium lauryl sulfate.
• the surfactant or mixtures of compatible surfactants can be present in the composition in 0.1 % to 5%, in another embodiment 0.3% to 3% and in another embodiment 0.5% to 2% by weight of the total composition.
• anionic surfactants do not interfere with zinc amino acid halide complex or with the activity of the zinc. At relatively low levels and in a relatively low water formulation, the surfactants generally would not have major impact, but higher levels of anionic surfactant, particular!)' in aqueous formulations, anionic surfactants can be excluded, Cationic and/or nonionic surfactants may be utilized instead.
• compositions comprise an anticalculus (tartar control) agent.
• Suitable anticalculus agents include without limitation phosphates and polyphosphates (for example pyrophosphates), polyammopropanesulfomc acid (AMPS), hexametaphosphate salts, zinc citrate trihydrate, polypeptides, polyolefin sulfonates, polyolefin phosphates, diphosphonates.
• the compostion thus may comprise phosphate salts.
• these salts are alkali phosphate salts, i.e., salts of alkali metal hydroxides or alkaline earth hydroxides, for example, sodium, potassium or calcium salts.
• Phosphate encompasses orally acceptable mono- and polyphosphates, for example, Pj_6 phosphates, for example monomelic phosphates such as monobasic, dibasic or tribasic phosphate; dimeric phosphates such as pyrophosphates; and multimeric phosphates, e.g., sodium hexametaphosphate.
• the selected phosphate is selected from alkali dibasic phosphate and alkali pyrophosphate salts, e.g., selected from sodium phosphate dibasic, potassium phosphate dibasic, dicalcium phosphate dihydrate, calcium pyrophosphate, tetrasodiimi pyrophosphate, tetrapotassium pyrophosphate, sodium tripolyphosphate, and mixtures of any of two or more of these.
• the compositions comprise a mixture of tetrasodium pyrophosphate (Na ⁇ O ?
• compositions comprise a mixture of tetrasodium pyrophosphate (TSPP) and sodium ⁇ polyphosphate (STPP)( ⁇ % ⁇ 3 () ⁇ ), e.g., in proportions of TSPP at 1-2% and STPP at 7% to 10%.
• TSPP tetrasodium pyrophosphate
• STPP sodium ⁇ polyphosphate
• Such phosphates are provided in an amount effective to reduce erosion of the enamel, to aid in cleaning the teeth, and/or to reduce tartar buildup on the teeth, for example in an amount of 2-20%, e.g., ca. 5-15%, by weight of the composition.
• the oral care compositions may also include a flavoring agent.
• Flavoring agents which can be used in the composition include, but are not limited to, essential oils as well as various flavoring aldehydes, esters, alcohols, and similar materials.
• the essential oils include oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, lime, grapefruit, and orange. Also useful are such chemicals as menthol, carvone, and anethole. Certain embodiments employ the oils of peppermint and spearmint.
• the flavoring agent may be incorporated in the oral composition at a concentration of 0.1 to 5% by weight e.g. 0.5 to 1.5% by weight.
• the oral care compositions may also include additional polymers to adjust the viscosity of the formulation or enhance the solubility of other ingredients.
• additional polymers include polyethylene glycols, polysaccharides (e.g., cellulose derivatives, for example carboxymethyl cellulose, or polysaccharide gums, for example xanthan gum or carrageenan gum).
• Acidic polymers, for example poiyacrylate gels may be provided in the form of their free acids or partially or fully neutralized water soluble alkali metal (e.g., potassium and sodium) or ammonium salts.
• Silica thickeners which form polymeric structures or gels in aqueous media, may be present. Note that these silica thickeners are physically and functionally distinct from the particulate silica abrasives also present in the compositions, as the silica thickeners are very finely divided and provide little or no abrasive action.
• Other thickening agents are earboxyvinyl polymers, carrageenan, hydroxyethyl cel lulose and water soluble salts of cellulose ethers such as sodium earhoxymethy! cellulose and sodium carboxymethyl hydroxyethyl cellulose. Natural gums such as karaya, gum arable, and gum tragacanth can also be incorporated. Colloidal magnesium aluminum silicate can also be used as component of the thickening composition to
• thickening agents in an amount of 0.5% to 5.0% by weight of the total composition are used.
• compositions may include an anionic polymer, for example in an amount of from 0.05 to 5%).
• anionic polymer for example in an amount of from 0.05 to 5%.
• Such agents are known generally for use in dentifrice, although not for this particular application, useful in composition are disclosed in U.S. Pat. Nos. 5,188,82! and 5,192,531; and include synthetic anionic polymeric polycarboxylates, such as 1 :4 to 4: 1 copolymers of maleic anhydride or acid with another polyrnerizable ethylenically unsaturated monomer, preferably methyl vinyl ether/maleic anhydride having a molecular weight (M.W.) of 30,000 to 1 ,000,000, most preferably 300,000 to 800,000. These copolymers are available for example as Gantrez.
• M.W. molecular weight
• AN 139 M.W. 500,000
• AN 1 19 M.W. 250,000
• S-97 Pharmaceutical Grade M.W. 700,000
• the enhancing agents when present are present in amounts ranging from 0.05 to 3%) by weight.
• Other operative polymers include those such as the 1 : 1 copolymers of maleic anhydride with ethyl acrylate, hydroxyethyl methacrylate, N-vinyl-2-pyrollidone, or ethylene, the latter being available for example as Monsanto EMA No. 1 103, M.W.
• Suitable generally are polymerized olefi.nical.ly or ethylenically unsaturated carboxylic acids containing an activated carbon-to-carbon olefinic double bond and at least one carboxyl group, that is, an acid containing an olefinic double bond which readily functions in polymerization because of its presence in the monomer molecule either in the alpha-beta position with respect to a carboxyl group or as part of a terminal methylene grouping.
• Such acids are acrylic, methaciylic, ethacrylic, alpha-chloroacrylic, cro tonic, beta-acryloxy propionic, sorbic, alpha-chlorsorbic, cinnamic, beta- styryl acrylic, muconic, itaconic, citraconic, mesaconic, glutaconic, aconitic, a Ipha-phenyl acrylic, 2-benzyl acrylic, 2-cyclohexylacrylic, angelic, umbellic, fumaric, maleic acids and anhydrides.
• Other different olefinic monomers copolymerizabie with such carboxylic monomers include vinylacetate, vinyl chloride, dimethyl maleate and the like.
• Copolymers contain sufficient carboxylic salt groups for water-solubility
• a further class of polymeric agents includes a composition containing homopolymers of substituted acrylamides and/or homopolymers of unsaturated sulfonic acids and salts thereof, in particular where polymers are based on unsaturated sulfonic acids selected from acrylamidoalykane sulfonic acids such as 2-acrylamide 2 methylpropane sulfonic acid having a molecular weight of 1,000 to 2,000,000, described in U.S. Pat. No. 4,842,847, Jim. 27, 1989 to Zahid.
• polymeric agents include polyamino acids containing proportions of anionic surface-active amino acids such as aspartic acid, glutamic acid and phosphoserine, e.g. as disclosed in U.S. Pat. No. 4,866,161 Sikes et al.
• the oral compositions may comprise significant levels of water. Water employed in the preparation of commercial oral compositions should be deionized and free of organic impurities. The amount of water in the compositions includes the free water which is added plus that amount which is introduced with other materials.
• Humectants Within certain embodiments of the oral compositions, it is also desirable to incorporate a humectant to prevent the composition from hardening upon exposure to air. Certain humectants can also impart desirable sweetness or flavor to dentifrice compositions. Suitable humectants include edible polyhydric alcohols such as glycerine, sorbitol, xylitol, propylene glycol as well as other polyols and mixtures of these humectants. in one embodiment, the principal humectant is glycerin, which may be present at levels of greater than 25%, e.g. 25- 35% 30%, with 5% or less of other humectants.
• the oral care embodiments can contain a variety of optional dentifrice ingredients some of which are described below.
• Optional ingredients include, for example, but are not limited to, adhesives, sudsing agents, flavoring agents, sweetening agents, additional antiplaque agents, abrasives, and coloring agents. These and other optional components are further described in U.S. Pat. No. 5,004,597, to Majeti; U.S. Pat. No. 3,959,458 to Agricola et al. and U.S. Pat. No. 3,937,807, to Haefele, all being incorporated herein by reference.
• the form of the dual component system can take the form of a dual chamber form or any other means to separate the components which include, but is not limited to beads, capsules, and films.
• compositions and formulations as provided herein are described and claimed with reference to their mgredients, as is usual in the art. As would be evident to one skilled in the art, the ingredients may in some instances react with one another, so that the true composition of the final formulation may not correspond exactly to the ingredients listed. Thus, it should be understood that the composition extends to the product of the combination of the listed mgredients,
• pH stock 2 10.024
• reaction delay no observable reaction
• pH stock 2 10.024
• reaction delay no observable reaction
• pH stock 2 10.024
• cysteine HCI can have a similar effect in comparison to acidified aqueous cysteine.
• pH of stock 1 2.104
• the reaction delay can be important for oral care applications inparticular.
• adding glycerin to the second stock (TBZC-Lysine) one can effectively lengthen the reaction delay to a desired amount. For example:
• the invention consists of a two stock solution.
• the first stock contains an aqueous solution of acidified cysteine or cysteine-HCl.
• the second stock contains TBZC-iysine with a variable amount of glycerin.
• the bottle In a soap container, the bottle is divided by a barrier. Both sides of the barrier contain the standard soap base in the table immediately above. One side contains the appropriate amount of cysteine and the other side contains the appropriate amount of TBZC-lys. When dispensed , the two stocks will mix in the nozzle forming an instantaneous precipitation directly to the skin's surface without having a reaction occur within the bottle that may expend all the desired benefits.
• the ingredients are placed in a tube.
• the tube is separated by means of either a physical divider resulting in two chambers, one chamber containing cysteine and the other containing TBZC-lys.
• the fomiulation does not react due to the appropriate desired delay.
• a precipitate forms to occlude tubules and provides zinc ion benefits to the oral surfaces.

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