WO2013153812A1 - 撹拌用注入装置 - Google Patents

撹拌用注入装置 Download PDF

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Publication number
WO2013153812A1
WO2013153812A1 PCT/JP2013/002458 JP2013002458W WO2013153812A1 WO 2013153812 A1 WO2013153812 A1 WO 2013153812A1 JP 2013002458 W JP2013002458 W JP 2013002458W WO 2013153812 A1 WO2013153812 A1 WO 2013153812A1
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WO
WIPO (PCT)
Prior art keywords
syringe
unit
holding unit
injection device
stirring
Prior art date
Application number
PCT/JP2013/002458
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
根本　茂
Original Assignee
株式会社根本杏林堂
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社根本杏林堂 filed Critical 株式会社根本杏林堂
Priority to JP2014510058A priority Critical patent/JP6463628B2/ja
Priority to CN201380019290.8A priority patent/CN104220110A/zh
Publication of WO2013153812A1 publication Critical patent/WO2013153812A1/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1456—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1458—Means for capture of the plunger flange

Definitions

  • the present invention relates to an injection device for injecting a chemical solution, and relates to an injection device for stirring for stirring the chemical solution in a mounted syringe.
  • a contrast medium made of a suspension as a chemical solution used for imaging by a medical imaging apparatus, for example, an ultrasonic diagnostic apparatus.
  • This contrast agent contains microbubbles, solid particles and the like in order to scatter ultrasonic waves.
  • a syringe filled with the contrast agent is attached to an injection device, and imaging is performed after the contrast agent is injected into the patient's body.
  • the ultrasonic diagnostic apparatus captures an image of the inside of a body by analyzing ultrasonic waves that are incident on and reflected by microbubbles or solid particles.
  • the contrast agent may be separated, and the concentration of the contrast agent content may be biased.
  • Patent Document 1 discloses an injection system for maintaining the suspension in the syringe of the injection device in a sufficiently stirred state.
  • the injection system is an injection system for treating a patient by injecting a suspension of microparticles in an aqueous liquid carrier.
  • the injection system consists of a syringe capable of filling the barrel with suspension and automatic electric drive means that controllably move to inject the suspension into the patient.
  • the injection system also has a stirring means for holding the syringe in the system and stirring the fine particles in the suspension. This stirring means maintains the uniformity of the suspension by preventing the separation of the fine particles due to gravity or buoyancy by the movement given to the syringe.
  • Patent Document 1 discloses a roller that is in contact with a syringe barrel in order to give continuous rotation to the syringe barrel as a stirring means.
  • the roller holds the syringe disposed on the roller and rotates the held syringe. Thereby, the roller can stir the suspension in the barrel of the syringe.
  • Patent Document 1 discloses two brackets that support a syringe in a rotatable manner as stirring means. These brackets hold the syringe and rotate the syringe. Thereby, the bracket stirs the suspension in the barrel of the syringe.
  • Patent Document 1 has the following problems. That is, when a syringe is held by being placed on a roller, the syringe is likely to be displaced and may be detached from the injection device. In addition, when injecting, in order to prevent injecting air into the patient, the syringe is mounted with the syringe mounting side (the syringe tip side) facing the floor surface. Sometimes. In this case, the syringe placed on the roller shifts due to gravity and comes off the injection device.
  • the held syringe is easily detached. That is, since the syringe is rotatably held, the syringe cannot be fixed to the blanket that is also a holding means. Furthermore, since it is necessary to observe the chemical solution from the outside, it is difficult to provide a member that covers the upper surface of the syringe in order to fix the syringe. Therefore, also when hold
  • the posture of the syringe may be tilted in the injection device. And if the attitude
  • the syringe is held by stirring means. Therefore, the size or shape of the syringe that can be held is limited to the size or shape that the stirring means can accommodate. And in order to mount
  • an injection device for agitation is an injection device for injecting a chemical solution, the first drive unit for extruding the first chemical solution from a first syringe filled with the first chemical solution, A first holding unit that fixes and holds the first syringe, a support member that supports the first holding unit, and the first drug solution in the first syringe are agitated while being connected to the first holding unit. And a stirring unit for moving the first holding unit.
  • the stirring injection device of the present invention is an injection device for injecting a chemical solution, a drive unit for pushing out the chemical solution from a syringe filled with the chemical solution, a holding unit for fixing and holding the syringe, and the holding device A support member that supports the unit, and a stirring unit that contacts the outer surface of the syringe at a position spaced from the holding unit and moves the syringe in order to stir the drug solution in the syringe.
  • the syringe is fixed to and held by the holding unit. Therefore, even if the tip end side of the syringe is directed to the floor surface, it is possible to prevent the syringe from shifting during the stirring operation.
  • the chemical solution can be agitated while maintaining the tip portion of the syringe in a clean state.
  • syringes of various sizes or shapes can be attached to the stirring injection device.
  • FIG. 1 shows an injection device (injector) 100 used when a patient's body is imaged by a medical imaging device, for example, an ultrasonic diagnostic device, and a stand 2 that holds an injector head 1 that is a head portion of the injection device.
  • a medical imaging device for example, an ultrasonic diagnostic device
  • the stand 2 has a movable stand base placed on the floor and a stand pole on the stand base.
  • the injector head 1 is held on the top or side of the stand pole.
  • the injector head 1 is held by a stand pole so as to be rotatable in the left-right direction or the up-down direction.
  • the injector head 1 has a posture in which the tip side (side where the syringe is mounted) of the injector head 1 is directed to the floor surface, and the rear end side (side where the syringe is not mounted) of the injector head 1 is the floor surface. It can be rotated to the direction it faces.
  • FIG. 1 shows a state in which a syringe is attached to the injector head 1 and preparations for injecting a chemical solution are ready. Therefore, the injector head 1 is inclined so that the tip side of the injector head 1 faces the floor surface.
  • the injector 100 that injects the chemical solution injects a contrast agent as the first chemical solution and physiological saline as the second chemical solution into the patient. Therefore, as shown in FIG. 2, the injector head 1 fixes the first holding unit 11 for fixing and holding the first syringe 4 filled with the contrast agent, and the second syringe 5 filled with physiological saline. And a second holding unit 12 for holding, and a support arm 14 as a support member for supporting the first holding unit 11 and the second holding unit 12.
  • the internal mechanisms of the first holding unit 11 and the second holding unit 12 are accommodated in the covers of the first holding unit 11 and the second holding unit 12. Further, the injector head 1 includes a stirring unit 13 connected to the first holding unit 11.
  • the internal mechanism of the stirring unit 13 is accommodated in the cover of the stirring unit 13. Then, the stirring unit 13 moves the first holding unit 11 in order to stir the contrast agent in the first syringe 4.
  • the first drive unit 16 that pushes out the contrast agent from the first syringe 4 is provided in the first holding unit 11.
  • a second drive unit 17 that pushes physiological saline from the second syringe 5 is provided in the second holding unit 12.
  • the first holding unit 11 has a syringe adapter 6.
  • the first syringe 4 is fixed to the first holding unit 11 by holding the cylinder flange 41 of the first syringe 4 on the syringe adapter 6. Thereby, it can prevent that the 1st syringe 4 shifts
  • the cylinder flange 51 of the second syringe 5 is held by the syringe adapter 6 provided on the support arm 14. Thereby, the second syringe 5 is held by the second holding unit 12.
  • These syringe adapters 6 have a recess, and the cylinder flanges 41 and 51 are inserted into the recess. Therefore, attachment and removal of the first syringe 4 and the second syringe 5 are very easy.
  • the syringe adapter 6 is detachably attached to the first holding unit 11 or the support arm 14. And the syringe adapter 6 can be replaced
  • the cylinder 42 of the first syringe 4 is supported by the syringe adapter 6 and a cylinder receiving part 110 provided in the first holding unit 11. Further, the cylinder 52 of the second syringe 5 is supported by the syringe adapter 6 and a cylinder receiving portion 120 provided on the support arm 14.
  • the cylinder receiving portions 110 and 120 protrude outward from the first holding unit 11 or the support arm 14.
  • the cylinder receivers 110 and 120 have a substantially U-shaped cross section along the outer shape of the cylinders 42 and 52 and can be exchanged together with the syringe adapter 6. That is, the cylinder receiving portions 110 and 120 can be exchanged according to the size or shape of the syringe.
  • the first holding unit 11 has a heater (not shown) that contacts the outer surface of the first syringe 4.
  • the heater is provided in a cylinder receiving part 110 provided in the first holding unit 11 and heats or keeps the cylinder 42 of the first syringe 4.
  • This heater is arranged on the upper surface of the cylinder receiving part 110 or is built in the cylinder receiving part 110. By heating with the heater, convection occurs in the contrast medium in the cylinder 42, and the stirring effect of the contrast medium can be further enhanced. This heating is performed at a temperature that does not cause the microbubbles to collapse. Further, by keeping the contrast medium warm by a heater, a predetermined temperature, for example, a temperature about the human body temperature can be maintained.
  • a conduit portion 43 is provided at the tip of the first syringe 4, and a conduit portion 53 is provided at the tip of the second syringe 5. And the holding member is not arrange
  • a tube 9 is connected to the conduit portions 43 and 53 when a chemical solution is injected.
  • the tube 9 includes a first tube 91 connected to the first syringe 4 and a second tube 92 connected to the second syringe 5.
  • the 1st tube 91 and the 2nd tube 92 are connected via the branch part.
  • the tube 9 has a distal end portion 95 connected to a catheter or the like, and a dripping cap is attached to the distal end portion 95.
  • a first connector 93 is attached to the end of the first tube 91, and a second connector 94 is attached to the conduit portion 43 of the first syringe 4.
  • the second connector 94 is inserted into the first connector 93 and is rotatably connected to the first connector 93.
  • the first holding unit 11 swings in a direction that intersects the axial direction of the first syringe 4.
  • the second connector 94 is rotatably connected to the first connector 93, the tube 9 is not twisted.
  • the second connector 94 and the first connector 93 can be screwed together. By screwing, even if the tube 9 moves according to the swing of the first syringe 4, the connection between the second connector 94 and the first connector 93 is not released.
  • a piston 44 is attached to the first syringe 4, and a piston 54 is attached to the second syringe 5.
  • the rear end of the piston 44 engages with the presser 160 of the first drive unit 16, and the rear end of the piston 54 engages with the presser 170 of the second drive unit 17.
  • the pressers 160 and 170 advance or retract the pistons 44 and 54 separately or simultaneously in the axial direction of the syringe.
  • the pistons 44 and 54 move forward and the contrast medium and physiological saline in the cylinders 42 and 52 are pushed out.
  • the extruded contrast agent and physiological saline are injected into the patient's blood vessel through the tube 9 and a catheter or the like connected to the distal end portion 95.
  • physiological saline is often injected after contrast agent injection, but the contrast agent and physiological saline can also be injected simultaneously.
  • the release valve 96 of the tube 9 When confirming the blood vessel, the release valve 96 of the tube 9 is used. When the release valve 96 is pushed, the liquid can flow from the blood vessel side to the second syringe 5 side. Therefore, it can be confirmed that the blood is returned by retracting the presser 170 to retract the piston 54. At this time, a valve is provided in the first connector 93 so that the contrast agent does not flow into the second syringe 5 from the first syringe 4. This valve is not opened below a predetermined pressure, and is opened when a predetermined pressure is exceeded. Therefore, the liquid can flow only in the direction from the first syringe 4 toward the distal end portion 95.
  • the release valve 96 is also provided with a valve that restricts the liquid to flow only in the direction from the second syringe 5 toward the distal end portion 95 when the chemical liquid is injected. After confirming that the blood has returned, a small amount of physiological saline is injected.
  • a three-way stopcock can be provided at the branch portion between the first tube 91 and the second tube 92. Thereby, the flow direction of a liquid can be switched manually or automatically.
  • the injector head 1 includes an operation unit 19 capable of operating the injection and stirring of the chemical solution, and a first drive unit 16 and a second drive unit for controlling the injection operation of the injector head 1. 17 and a control unit 18 for controlling the stirring unit 13.
  • the first drive unit 16 includes an injection motor 161 that drives the presser 160, and a conversion mechanism 162 that converts the rotational motion from the injection motor 161 into linear motion.
  • the second drive unit 17 includes an injection motor 171 that drives the presser 170 and a conversion mechanism 172 that converts the rotational motion from the injection motor 171 into a linear motion.
  • the stirring unit 13 includes a stirring motor 130 that drives the first holding unit 11 and a transmission mechanism 131 that transmits the rotational motion from the stirring motor to the first holding unit 11.
  • the first holding unit 11 is supported so as to be swingable in a direction intersecting the axial direction of the first syringe 4, preferably in a direction perpendicular to the first syringe 4, in a state sandwiched between the pair of support arms 14 and 15. That is, the shaft 141 is fixed to the distal end side of the first holding unit 11, and the first holding unit 11 is swingably supported by the support arm 14 via the shaft 141. A shaft 151 is fixed to the rear end side of the first holding unit 11, and the first holding unit 11 is swingably supported by the support arm 15 via the shaft 151.
  • the first holding unit 11 can swing in the axial direction with the central axis of the cylinder 42 of the first syringe 4 as the axis.
  • the shaft 151 passes through the shaft hole of the support arm 15, and the first holding unit 11 is connected to the transmission mechanism 131 of the stirring unit 13 through the shaft 151.
  • the shaft 141 is coaxial with the shaft 151, and the end of the shaft 141 passes through the shaft hole of the support arm 14. Thereby, the 1st holding
  • the stirring unit 13 is fixed to the support arm 14, and the second holding unit 12 is fixed and held while being sandwiched between the pair of support arms 14 and 15.
  • the operator When injecting a chemical solution, the operator operates the injector head 1 with the operation unit 19.
  • the operator inputs physical data of the patient such as weight, data on the type of the chemical solution, and the like from the operation unit 19.
  • the control unit 18 calculates an injection protocol such as an injection rate, an injection amount, and an injection time based on the input data.
  • the control part 18 of the injector head 1 operates the injector head 1 according to an injection
  • pouring protocol For example, when the operator inputs the start of injection, the control unit 18 drives the injection motors 161 and 171.
  • the rotational motions of the injection motors 161 and 171 are converted into linear motions by the conversion mechanisms 162 and 172 and transmitted to the pressers 160 and 170.
  • the injector head 1 includes an operation unit 19 and a control unit 18.
  • the operation unit 19 and the control unit 18 can be provided outside the injector head 1.
  • the injector head 1, the operation unit 19, and the control unit 18 are connected by wire or wireless, and the injector head 1 can be remotely operated.
  • the operator stirs the contrast agent before injecting the drug solution.
  • the operator attaches the first syringe 4 to the first holding unit 11.
  • the operator operates the operation unit 19 and inputs the start of the stirring operation.
  • the operation unit 19 transmits a control signal for starting the stirring operation to the control unit 18.
  • the control unit 18 that has received the control signal drives the stirring motor 130 to cause the stirring unit 13 to perform a predetermined stirring operation.
  • the rotational motion from the stirring motor 130 is transmitted to the shaft 151 via the transmission mechanism 131. Since the shaft 151 is fixed to the first holding unit 11, the first holding unit 11 swings according to the rotation of the shaft 151.
  • the stirring time is 10 seconds to 300 seconds
  • the rotation speed is 10 rpm to 120 rpm
  • the swing angle of the first holding unit 11 is 45 degrees to 360 degrees.
  • the stirring operation can be performed so as to repeat swinging in one direction and swinging in the opposite direction.
  • the first holding unit 11 is swung 180 degrees in one direction. That is, the first holding unit 11 is swung until the side where the first syringe 4 of the first holding unit 11 is attached faces downward. Thereafter, the first holding unit 11 is swung 180 degrees in the reverse direction. That is, the first holding unit 11 is swung so as to return to the original position.
  • the first holding unit 11 is swung 45 degrees in one direction. Thereafter, the first holding unit 11 is swung 90 degrees in the reverse direction. That is, the first holding unit 11 is swung 45 degrees in the reverse direction through the original position.
  • the stirring operation can be automatically started when the separation of the contrast agent is detected.
  • the separation of the contrast agent can be detected by a CCD camera or a sensor.
  • a CCD camera an image of the contrast agent in the cylinder 42 can be taken by the CCD camera, and the separation of the contrast agent can be recognized from the taken image.
  • it can be set so that the stirring operation is automatically performed every predetermined time.
  • control unit 18 performs control so as not to start injection during the stirring operation. That is, the control unit 18 starts injecting the chemical liquid after the first holding unit 11 stops swinging. Therefore, when the control unit 18 receives an injection start signal during the stirring operation, the control unit 18 drives the injection motors 161 and 171 after waiting for the stirring operation to end. Thereby, the tube 9 does not move due to the swinging of the first holding unit 11, and it is possible to prevent the catheter or the like from being detached from the patient during the injection.
  • the control part 18 can also make the stirring unit 13 perform stirring operation, when starting injection
  • control unit 18 that has received the injection start control signal causes the stirring unit 13 to perform the stirring operation, and drives the injection motors 161 and 171 after the stirring operation is completed.
  • the control unit 18 performs control so that the injection is not started during the stirring operation.
  • the stirring operation can be performed during the injection.
  • the first drive unit 16 and the second drive unit 17 will be described with reference to FIG.
  • the first drive unit 16 is arranged in the cover of the first holding unit 11, and the second drive unit 17 is arranged in the cover of the second holding unit 12.
  • the first drive unit 16 and the second drive unit 17 have injection motors 161 and 171 and conversion mechanisms 162 and 172, respectively.
  • the injection motors 161 and 171 are, for example, stepping motors.
  • the conversion mechanisms 162 and 172 include ball screws 163 and 173 and ball nut units 160 and 170 that function as a presser.
  • the first holding unit 11 includes a frame including a front end member 114 located on the front end side, a rear end member 115 located on the rear end side, and a beam member 116 that connects the front end member 114 and the rear end member 115.
  • a frame including a front end member 114 located on the front end side, a rear end member 115 located on the rear end side, and a beam member 116 that connects the front end member 114 and the rear end member 115.
  • the ball screws 163 and 173 are connected to the output shafts of the injection motors 161 and 171 via two pulleys and a belt (not shown).
  • One pulley is fixed to the output shafts of the injection motors 161 and 171, and the other pulley is fixed to the ends of the ball screws 163 and 173.
  • Belts are wound around the two pulleys, and the rotational movements of the injection motors 161 and 171 are transmitted to the ball screws 163 and 173. Instead of the two pulleys and the belt, the rotational motion may be transmitted to the ball screws 163 and 173 by a gear.
  • the ball screw 163 of the first driving unit 16 is supported by the front end member 114 and the rear end member 115 of the frame so as to be rotatable and immovable in the axial direction.
  • a guide shaft 165 passing through the ball nut unit 160 is fixed to the front end member 114 and the rear end member 115.
  • the ball screw 173 of the second drive unit 17 is supported by the support arms 14 and 15 so as to be rotatable and immovable in the axial direction.
  • a guide shaft 175 that passes through the ball nut unit 170 is fixed to the support arms 14 and 15. The ball nut units 160 and 170 are screwed into the ball screws 163 and 173.
  • the ball nut units 160 and 170 linearly move along the guide shafts 165 and 175 as the ball screws 163 and 173 rotate. Specifically, when the injection motors 161 and 171 are driven, the rotational motion is transmitted to the ball screws 163 and 173 via the pulleys and the belt, and the ball screws 163 and 173 rotate. When the ball screws 163 and 173 rotate, the ball nut units 160 and 170 move forward or backward along the ball screws 163 and 173 according to the rotation direction. Further, the rear ends of the pistons 44 and 54 are engaged with and held by the ball nut units 160 and 170 via the engaging portions 164 and 174.
  • the stirring unit 13 includes a stirring motor 130 and a transmission mechanism 131 that transmits the rotational force from the stirring motor 130 to the shaft 151.
  • the stirring motor 130 is, for example, a stepping motor.
  • the first holding unit 11 is connected to the transmission mechanism 131 via the shaft 151.
  • the transmission mechanism 131 includes a first gear 132, a second gear 133, a third gear 134, a fourth gear 135, and a belt 136.
  • the first gear 132 is connected to and fixed to the output shaft of the stirring motor 130, and the second gear 133 has external teeth that mesh with the external teeth of the first gear 132.
  • the third gear 134 is coaxial with the second gear 133 and is bolted and fixed to the second gear 133.
  • the third gear 134 and the fourth gear 135 have external teeth that mesh with the internal teeth of the belt 136.
  • the fourth gear 135 is fixed to the shaft 151, and the shaft 151 is fixed to the rear end member 115 of the first holding unit 11.
  • Rotational motion from the stirring motor 130 is transmitted to the first gear 132 via the output shaft.
  • the second gear 133 rotates according to the rotation of the first gear 132.
  • the third gear 134 fixed to the second gear 133 rotates around the shaft 152 as the second gear 133 rotates.
  • the belt 136 having the internal teeth that mesh with the external teeth of the third gear 134 rotates according to the rotation of the third gear 134.
  • the fourth gear 135 having external teeth that mesh with the internal teeth of the belt 136 rotates according to the rotation of the belt 136. Since the shaft 151 is fixed to the fourth gear 135, the shaft 151 rotates according to the rotation of the fourth gear 135.
  • the shaft 151 is fixed to the rear end member 115 of the first holding unit 11. Therefore, according to the rotation of the shaft 151, the first holding unit 11 swings around the shaft 151 with respect to the support arms 14 and 15.
  • the stirring motor 130 is controlled by the control unit 18 so as to swing the first holding unit 11 at a predetermined swing angle. That is, the stirring motor 130 is controlled so that the first holding unit 11 reciprocates within a predetermined angle range from a horizontal direction with respect to the central axis of the shaft 151. Therefore, the first syringe 4 held and fixed by the first holding unit 11 also swings together with the first holding unit 11. Thereby, the contrast agent in the 1st syringe 4 is stirred.
  • the injector head 1 is used in a two-cylinder injector including a first holding unit 11 and a second holding unit 12. Therefore, the contrast agent can be agitated by swinging the first syringe 4 held by the first holding unit 11 as the other holding unit with the second holding unit 12 as one holding unit as a base. it can.
  • the agitated contrast agent can be injected while being swept together with physiological saline.
  • the injector head 1 can be suitably used.
  • the contrast agent does not stay between the injection site and the heart, and there is no possibility of adversely affecting the quality of the captured image.
  • As an injection method it is possible to inject contrast medium and physiological saline again after injecting physiological saline followed by injection of contrast medium. As a result, the inspection can be performed twice.
  • the chemical solution in the syringe is agitated by swinging the holding unit that fixes and holds the syringe by the agitation unit. That is, the syringe swings together with the holding unit while being fixed to the holding unit. Thereby, even if stirring operation is performed, it can prevent that a syringe will shift. Moreover, the attachment and removal of the syringe are easy, and different types of syringes can be attached inexpensively and easily without replacing the stirring unit. Further, no holding member is disposed in the vicinity of the distal end portion of the syringe. Therefore, the tip portion of the syringe is kept clean.
  • the first holding unit 11 is swung in a direction intersecting with the axial direction of the first syringe 4.
  • the first holding unit 11 swings in a direction along the axial direction of the first syringe 4.
  • the same reference numerals will be given to the components described in the first embodiment, and description thereof will be omitted. Except where specifically described, the constituent elements having the same reference numerals perform substantially the same operations and functions, and the effects thereof are also substantially the same.
  • beams 216 and 217 are provided between the support arms 14 and 15.
  • the first holding unit 11 is supported so as to be swingable with respect to the beams 216 and 217 via shafts 241 and 251.
  • the shaft 241 on the stirring unit 13 side passes through the shaft hole of the beam 217 and is connected and fixed to the transmission mechanism 131.
  • the shaft 251 on the second holding unit 12 side passes through the shaft hole formed in the beam 216.
  • the second holding unit 12 and the stirring unit 13 are arranged between the support arms 14 and 15 and are fixed to the support arms 14 and 15.
  • the stirring unit 13 includes a stirring motor 130 and a transmission mechanism 131.
  • the rotational motion from the stirring motor 130 is transmitted to the first gear 132 of the transmission mechanism 131 via the output shaft.
  • the fourth gear 135 rotates via the second gear 133, the third gear 134, and the belt 136.
  • the shaft 241 is fixed to the fourth gear 135, the shaft 241 rotates according to the rotation of the fourth gear 135.
  • the shaft 241 is fixed to the beam member 116 of the first holding unit 11 described above, the first holding unit 11 swings as the shaft 241 rotates.
  • maintenance unit 11 is stirred.
  • the chemical solution in the syringe is stirred by swinging the holding unit that fixes and holds the syringe by the stirring unit. That is, the syringe swings together with the holding unit while being fixed to the holding unit. Thereby, even if stirring operation is performed, it can prevent that a syringe will shift. Moreover, the attachment and removal of the syringe are easy, and different types of syringes can be attached inexpensively and easily without replacing the stirring unit. Further, no holding member is disposed in the vicinity of the distal end portion of the syringe. Therefore, the tip portion of the syringe is kept clean.
  • the stirring unit 13 includes a stirring motor 130 and a link mechanism 331 connected to the stirring motor 130.
  • the first holding unit 11 is connected to the link mechanism 331.
  • the link mechanism 331 includes a disk 332 fixed to the output shaft of the stirring motor 130 and a rod 333 connected to the disk 332 via a pin at a position shifted from the rotation axis of the disk 332.
  • the frame of the first holding unit 11 includes a front end member 314 and a rear end member 315, and a beam member 316 positioned between the front end member 314 and the rear end member 315.
  • the beam member 316 is fixed to the front end member 314 and the rear end member 315 by bolts.
  • the end of the rod 333 is connected to a slider 334 protruding from the beam member 316 via a pin.
  • the tip member 314 is connected to the cover 318 via two slide shafts 317.
  • the front end member 314, the rear end member 315, and the beam member 316 can slide linearly in the axial direction of the first syringe 4 within the cover 318. That is, the tip member 314 is connected to the slider shaft 317 so as to be able to advance and retract.
  • the control unit 18 drives the stirring motor 130.
  • the disk 332 connected to the output shaft rotates.
  • the rod 333 connected to the disk 332 is interlocked with the rotation of the disk 332.
  • the slider 334 reciprocates linearly in the axial direction of the first syringe 4 according to the movement of the rod 333.
  • the first holding unit 11 performs a linear reciprocating motion in the axial direction of the first syringe 4.
  • the first syringe 4 is fixed and held in the first holding unit 11. Therefore, the first syringe 4 performs a linear reciprocating motion as indicated by an arrow A in FIG. 7 as the first holding unit 11 slides. Thereby, the contrast agent in the 1st syringe 4 can be stirred.
  • the drug solution in the syringe is stirred by sliding the holding unit that holds and holds the syringe with the stirring unit. That is, the syringe slides together with the holding unit while being fixed to the holding unit. Thereby, even if stirring operation is performed, it can prevent that a syringe will shift. Moreover, the attachment and removal of the syringe are easy, and different types of syringes can be attached inexpensively and easily without replacing the stirring unit. Further, no holding member is disposed in the vicinity of the distal end portion of the syringe. Therefore, the tip portion of the syringe is kept clean.
  • the injector 1 for injecting the chemical solution of the fourth embodiment also has a first drive unit 16 that pushes out the contrast medium as the chemical solution from the first syringe 4 filled with the chemical solution, and a first holding that fixes and holds the first syringe 4.
  • a unit 11 and a support arm 14 that supports the first holding unit 11 are provided.
  • the injector 1 is provided with the stirring unit 13 which moves the 1st syringe 4 in order to stir the chemical
  • the stirring unit 13 has a vibration motor as a stirring motor in the vibration box 430.
  • the vibration motor is driven by the control unit 18, and vibration is transmitted to the first syringe 4.
  • the vibration box 430 is supported by a swing arm 431 that can swing around an axis.
  • the swing arm 431 is connected to the tip member 314 of the first holding unit 11 or the support arm 14 (not shown) via a shaft. Therefore, the swing arm 431 and the vibration box 430 can swing between the contact position and the retracted position.
  • the swing arm 431 is fixed by a lock means (not shown) at the contact position shown in FIG.
  • the vibration box 430 contacts the upper surface of the first syringe 4 at the contact position.
  • the vibration box 430 is separated from the first syringe 4 in the retracted touch position.
  • the first arm 4 is swung after the rocking arm 431 is unlocked and moved in the direction indicated by the arrow B in FIG. 8.
  • the vibration box 430 can be brought into contact with the lower surface or the side surface of the first syringe 4.
  • the swing arm 431 is configured to be swingable between a contact position below the first syringe 4 and a retracted position.
  • the chemical solution in the syringe is stirred by the stirring unit applying vibration to the syringe fixed and held by the holding unit. That is, the syringe vibrates while being fixed to and held by the holding unit. Thereby, even if stirring operation is performed, it can prevent that a syringe will shift. Moreover, the attachment and removal of the syringe are easy, and different types of syringes can be attached inexpensively and easily without replacing the stirring unit. Further, no holding member is disposed in the vicinity of the distal end portion of the syringe. Therefore, the tip portion of the syringe is kept clean.
  • an injector according to a fifth embodiment will be described with reference to FIG.
  • the support arm 14 is provided on the front end side of the first holding unit 11, and the support arm 15 is provided on the rear end side of the first holding unit 11.
  • the support member that supports the first holding unit 11 is disposed so as to avoid the distal end side of the first holding unit 11.
  • differences from the first embodiment will be described, and the same reference numerals will be given to the components described in the first embodiment, and description thereof will be omitted. Except where specifically described, the constituent elements having the same reference numerals perform substantially the same operations and functions, and the effects thereof are also substantially the same.
  • the injector head 1 is provided with a first holding unit 11, a second holding unit 12, and a stirring unit 13.
  • a support arm 15 (not shown) as a support member is disposed in the stirring unit 13.
  • the support arm 14 is not provided, and the distal end side of the first holding unit 11 is a free end. Therefore, there is no possibility that the first syringe 4 contacts the support arm 14 during the stirring operation. Thereby, the freedom degree of stirring operation can be raised.
  • the stirring operation of the fifth embodiment can be performed so as to rotate the first holding unit 11 in one direction for a predetermined time.
  • stirring operation can also be performed as follows. First, the first holding unit 11 is swung 180 degrees in one direction. That is, the first holding unit 11 is swung until the side where the first syringe 4 of the first holding unit 11 is attached faces downward. Thereafter, the first holding unit 11 is swung 360 degrees in the reverse direction. That is, the first holding unit 11 is swung in the reverse direction until it passes through the original position and the side on which the first syringe 4 is mounted faces downward.
  • the stirring operation can be performed in the same manner as in the first embodiment.
  • the stirring unit 13 includes a stirring motor 130 and a transmission mechanism 131.
  • the rotational motion from the stirring motor 130 is transmitted to the first gear 132 of the transmission mechanism 131 via the output shaft.
  • the fourth gear 135 rotates via the second gear 133, the third gear 134, and the belt 136.
  • the shaft 151 is fixed to the fourth gear 135, the shaft 151 rotates according to the rotation of the fourth gear 135.
  • the shaft 151 is fixed to the rear end member 115 of the first holding unit 11, the first holding unit 11 swings as the shaft 151 rotates.
  • maintenance unit 11 is stirred.
  • the first holding unit 11 and the stirring unit 13 are separated by a predetermined distance. Thereby, it is possible to prevent the operator's finger from being accidentally pinched or caught in the swing while the first holding unit 11 is swinging.
  • the first holding unit 11 can be covered with a transparent cover.
  • the cover has an open front end so as not to limit the swing of the first holding unit 11.
  • the inner space of the cover is configured so as not to come into contact with the swinging first holding unit 11. Thereby, since the upper surface side, side surface side, and lower surface side of the 1st holding
  • the operation unit 519 of the fifth embodiment is a touch panel supported by a pole extending above the stirring unit 13.
  • the touch panel 519 displays the injection status. Further, the operator can operate the injector head 1 by operating the touch panel 519.
  • the chemical solution in the syringe is stirred by swinging the holding unit that fixes and holds the syringe by the stirring unit. That is, the syringe swings together with the holding unit while being fixed to the holding unit. Thereby, even if stirring operation is performed, it can prevent that a syringe will shift. Moreover, the attachment and removal of the syringe are easy, and different types of syringes can be attached inexpensively and easily without replacing the stirring unit. Further, no holding member is disposed in the vicinity of the distal end portion of the syringe. Therefore, the tip portion of the syringe is kept clean. In addition, the arrangement
  • the injector head 1 is provided with a first holding unit 11, a second holding unit 12, and a stirring unit 13.
  • a support arm 14 (not shown) as a support member is disposed in the stirring unit 13.
  • the first holding unit 11 is supported by the support arm 14 and the support arm 15.
  • the cover that accommodates the stirring unit 13 and the second holding unit 12 is integrally formed.
  • the stirring unit 13 is disposed on the distal end side of the first holding unit 11. That is, the distal end side of the first holding unit 11 is connected to the transmission mechanism 131 of the stirring unit 13 via a shaft 141 (not shown).
  • the control part 18 accommodated in the cover is connected to the 1st holding
  • the length of the first holding unit 11 is longer than that of the first syringe 4 so that the first syringe 4 does not protrude from the first holding unit 11. Therefore, there is no possibility that the first syringe 4 contacts the support arm 14 or the stirring unit 13. Thereby, the freedom degree of stirring operation can be raised. Therefore, the stirring operation of the sixth embodiment can be performed so as to rotate the first holding unit 11 in one direction for a predetermined time. Moreover, stirring operation can also be performed as follows. First, the first holding unit 11 is swung 180 degrees in one direction. That is, the first holding unit 11 is swung to a position where the side on which the first syringe 4 of the first holding unit 11 is attached faces downward.
  • the first holding unit 11 is swung 360 degrees in the reverse direction. That is, the first holding unit 11 is swung in the reverse direction until it passes through the original position and the side on which the first syringe 4 is mounted faces downward.
  • the stirring operation can be performed in the same manner as in the first embodiment.
  • the stirring unit 13 of the sixth embodiment also includes a stirring motor 130 and a transmission mechanism 131.
  • the rotational motion from the stirring motor 130 is transmitted to the first gear 132 of the transmission mechanism 131 via the output shaft.
  • the fourth gear 135 rotates via the second gear 133, the third gear 134, and the belt 136.
  • the shaft 141 is fixed to the fourth gear 135, the shaft 141 rotates according to the rotation of the fourth gear 135. Since the shaft 141 is fixed to the tip member 114 of the first holding unit 11, the first holding unit 11 swings as the shaft 141 rotates.
  • the output shaft of the stirring motor 130 can be directly connected to the shaft 141.
  • the operator tilts the first syringe 4 and the second syringe 5 at a predetermined angle before performing the stirring operation. That is, the first holding unit 11 and the second holding unit 12 are manually tilted to the injection position. And the 1st holding
  • maintenance unit 11 is stirred.
  • a lifter can also be provided in order to incline the 1st holding
  • the operator operates the operation unit 19 and lifts the first holding unit 11 and the second holding unit 12 with a lifter.
  • maintenance unit 12 can be inclined automatically.
  • the chemical solution in the syringe is stirred by swinging the holding unit that fixes and holds the syringe by the stirring unit. That is, the syringe swings together with the holding unit while being fixed to the holding unit. Thereby, even if stirring operation is performed, it can prevent that a syringe will shift. Moreover, the attachment and removal of the syringe are easy, and different types of syringes can be attached inexpensively and easily without replacing the stirring unit. Further, no holding member is disposed in the vicinity of the distal end portion of the syringe. Therefore, the tip portion of the syringe is kept clean.
  • the chemical solution injection system includes an injector 100 as an injection device for injecting a chemical solution, and an external storage unit 700 such as a database server or an in-hospital information system that communicates with the injector 100 and stores patient information (medical chart information) and the like.
  • the chemical liquid injection system can also include a medical imaging apparatus 800 such as an ultrasonic diagnostic apparatus.
  • the injector head 1 of the injector 100 is provided with a control unit 18, an operation unit 19, a communication unit 71, and an RFID reader 72.
  • the first syringe 4 is provided with an RFID chip 73.
  • the RFID chip 73 stores at least chemical liquid data related to the chemical liquid to be injected.
  • the data includes, for example, data such as the name or ID of the chemical solution, viscosity, expiration date, syringe capacity, lot number, and the like.
  • the RFID chip 73 can also store data later by the injector head 1 or the like.
  • the RFID reader 72 is provided at a position where it can wirelessly communicate with the RFID chip 73 only when the first syringe 4 is correctly attached to the first holding unit 11.
  • the control unit 18 receives the injection condition data.
  • the control unit 18 acquires chemical liquid data from the RFID chip 73 by the RFID reader 72.
  • the control part 18 calculates an injection
  • the control unit 18 can also acquire injection condition data or an injection protocol from the external storage unit 700 via the communication unit 71.
  • the control unit 18 controls the first driving unit 16 and the second driving unit 17 according to the injection protocol to perform the injection operation. Furthermore, the control part 18 controls the stirring unit 13 as mentioned above, and performs stirring operation.
  • control unit 18 generates history data that records the history of the injection operation and the stirring operation. And the control part 18 can transmit historical data to the external memory
  • the history data of the stirring operation may include data such as the name of the chemical solution, the stirring time, and the rocking speed.
  • the history data of the injection operation may include data such as the name of the chemical solution, the injection time, and the injection speed.
  • the control unit 18 can also acquire data relating to an image, for example, data such as an ID, an imaging time, or an imaging region, from the ultrasonic diagnostic apparatus via the communication unit. And the control part 18 can memorize
  • the operator can send and receive information such as an injection protocol to the injector 100 using a terminal of the in-hospital information system.
  • the injector 100 includes a communication unit 71 that communicates with an external device. Thereby, the injector 100 can transmit / receive information to / from the medical imaging apparatus 800 such as an ultrasonic diagnostic apparatus or the external storage unit 700 such as a database server.
  • the medical imaging apparatus 800 such as an ultrasonic diagnostic apparatus or the external storage unit 700 such as a database server.
  • the injector 100 can transmit history data in which the history of the injection operation and the agitation operation is recorded to the external storage unit 700, or can receive a chemical injection protocol or the like from the external storage unit 700.
  • information such as the weight of the patient can be received from the external storage means 700 and the injection protocol can be calculated by the control unit 18 of the injector 100.
  • appropriate imaging can be performed by linking the injector 100 and the external storage unit 700 that stores patient information. Further, by linking the medical imaging apparatus 800, it is possible to perform imaging at an appropriate timing after the injection of the contrast medium.
  • the transmission mechanism 131 of the stirring unit 13 may be omitted, and the output shaft of the stirring motor 130 may be connected to the shaft 151.
  • the drive unit may have an ultrasonic motor instead of the stepping motor.
  • the second holding unit 12 is fixed, it can be swung in the same manner as the first holding unit 11.
  • the first holding unit 11 and the stirring unit 13 or the support arm 15 can be separated.
  • maintenance unit 11 and the support arm 14 can also be spaced apart. Thereby, it is possible to prevent the operator's finger from being accidentally pinched or involved in swinging.
  • the first holding unit 11 can be covered with a transparent cover.
  • the second holding unit 12 may further be provided with a heater (not shown) that contacts the outer surface of the second syringe 5.
  • the heater is provided in a cylinder receiving portion 120 provided in the second holding unit 12 and heats or keeps the cylinder 52 of the second syringe 5.
  • This heater is arranged on the upper surface of the cylinder receiving part 120 or is built in the cylinder receiving part 120.
PCT/JP2013/002458 2012-04-12 2013-04-11 撹拌用注入装置 WO2013153812A1 (ja)

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JP2014510058A JP6463628B2 (ja) 2012-04-12 2013-04-11 撹拌用注入装置
CN201380019290.8A CN104220110A (zh) 2012-04-12 2013-04-11 搅拌用注入装置

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JP2012091256 2012-04-12
JP2012-091256 2012-04-12

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WO2015141202A1 (ja) * 2014-03-17 2015-09-24 株式会社根本杏林堂 注入装置及び注入装置の制御装置
JP2016140691A (ja) * 2015-02-05 2016-08-08 公立大学法人奈良県立医科大学 シリンジ回転装置
WO2017179345A1 (ja) * 2016-04-14 2017-10-19 株式会社根本杏林堂 注入装置
CN113398364A (zh) * 2021-07-21 2021-09-17 胡春 心血管内科造影剂注射器
US20210338925A1 (en) * 2018-07-13 2021-11-04 Aptar France Sas Fluid product injection device
WO2023181578A1 (ja) * 2022-03-24 2023-09-28 テルモ株式会社 インデフレーション装置及びインデフレーションシステム

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JP6938019B2 (ja) * 2017-07-27 2021-09-22 株式会社根本杏林堂 着脱装置、及び複数回注入装置
CN108593789B (zh) * 2018-04-10 2020-11-27 浙江程诚文化用品有限公司 一种贴敷类医疗产品切割制液装置
CN113509607B (zh) * 2021-04-23 2023-04-18 温州医科大学附属第一医院 肺动脉高压心脏混合造影辅助装置
WO2024027842A1 (zh) * 2022-08-05 2024-02-08 苏州恒瑞宏远医疗科技有限公司 远程控制装置、远程系统、推注器、从机系统及注射系统

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CN104220110A (zh) 2014-12-17

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