WO2008004669A1 - Système de remplissage et d'injection de liquide chimique - Google Patents

Système de remplissage et d'injection de liquide chimique Download PDF

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Publication number
WO2008004669A1
WO2008004669A1 PCT/JP2007/063587 JP2007063587W WO2008004669A1 WO 2008004669 A1 WO2008004669 A1 WO 2008004669A1 JP 2007063587 W JP2007063587 W JP 2007063587W WO 2008004669 A1 WO2008004669 A1 WO 2008004669A1
Authority
WO
WIPO (PCT)
Prior art keywords
chemical
injection
chemical solution
syringe
filling
Prior art date
Application number
PCT/JP2007/063587
Other languages
English (en)
Japanese (ja)
Inventor
Shigeru Nemoto
Original Assignee
Nemoto Kyorindo Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nemoto Kyorindo Co., Ltd. filed Critical Nemoto Kyorindo Co., Ltd.
Priority to JP2008523760A priority Critical patent/JPWO2008004669A1/ja
Publication of WO2008004669A1 publication Critical patent/WO2008004669A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14546—Front-loading type injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A61M5/16827—Flow controllers controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/04—Tools for specific apparatus
    • A61M2209/045—Tools for specific apparatus for filling, e.g. for filling reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1456—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir

Definitions

  • the present invention relates to a chemical solution filling / injecting system having a chemical solution filling device that fills a chemical solution into a chemical solution syringe and a chemical solution injection device that injects a chemical solution from a chemical solution syringe filled with the chemical solution to a subject.
  • CT Compputed
  • the chemical solution injector has an injection head to which a chemical syringe is detachably attached.
  • the drug solution syringe is filled with the drug solution, and the drug solution in the drug solution syringe can be injected into the subject by pushing the piston of the drug solution syringe into the cylinder by the drive mechanism provided in the injection head.
  • the drug solution syringe is divided into a prefilled type in which a drug solution is pre-filled and a post-fill type in which a desired drug solution is filled in injection into a subject.
  • the liquid medicine is filled into the liquid medicine syringe exclusively by medical personnel at the medical site.
  • manually filling the chemical syringe with the chemical solution has a large work load, and therefore the chemical syringe is filled with the chemical solution using a chemical solution filling apparatus.
  • Patent Document 1 As a conventional chemical solution filling device, the device described in Patent Document 1 is known.
  • the chemical filling apparatus described in Patent Document 1 when the inspection condition is input, the amount of the necessary chemical is calculated based on the input inspection condition, and the piston member is moved according to the calculated amount of the chemical. Move. Thereby, the chemical solution is filled from the container into the chemical solution syringe.
  • Patent Document 2 chemical liquid data and syringe data are acquired by a chemical liquid filling apparatus, and the chemical liquid filling apparatus fills the chemical liquid from the chemical liquid container to the chemical liquid syringe based on these data.
  • chemical liquid data and syringe data are transmitted to a chemical liquid injector.
  • the chemical data includes data such as the type of chemical, whether it is for MR or CT, when it was used, and expiration date.
  • Syringe data includes data such as the types of chemicals that can be used, MR power, or CT use, and when, capacity, material, and expiration date.
  • the chemical liquid filling apparatus can determine the suitability of the combination of the chemical liquid and the syringe from the chemical liquid data and the syringe data, and the same determination can be made in the chemical liquid injection apparatus.
  • the chemical solution injection device determines that the combination of the chemical solution and the syringe is appropriate based on the data received from the chemical solution filling device, the chemical solution injection device injects the chemical solution from the chemical solution syringe. As a result, an inappropriate drug solution can be prevented from being injected into the subject.
  • Patent Document 1 JP 2000-189515 A
  • Patent Document 2 Japanese Patent Application Laid-Open No. 2004-313579
  • the chemical solution filling device described in Patent Document 1 is independent of the chemical solution injection device, and transmission / reception of data between the two is not considered.
  • the chemical injection device sets injection conditions such as the injection amount of the chemical solution to the subject.
  • the injection amount is determined based on the inspection conditions, and corresponds to the filling amount of the chemical solution filled in the chemical syringe with the chemical solution filling device.
  • the chemical injection device neither outputs the inspection conditions input to the chemical solution filling device nor the filling amount calculated by the chemical solution filling device to the outside as data. Therefore, the operator needs to input the same data to the chemical injection device as that input to the chemical filling device.
  • the present invention provides a chemical filling injection capable of preventing waste of chemicals and empty shots at the time of chemical injection while reducing the burden of operator data input when setting chemical injection conditions with a chemical injection device.
  • the purpose is to provide a system.
  • the chemical liquid filling and injection system of the present invention fills an empty chemical liquid syringe having a cylinder and a piston movably provided in the cylinder, and the chemical liquid is filled with the chemical liquid.
  • the chemical solution filling device calculates the filling amount of the chemical solution into the chemical solution syringe according to the test condition for the subject, and fills the chemical solution syringe by operating the chemical solution syringe based on the obtained filling amount.
  • the chemical injection device is equipped with a chemical syringe filled with a chemical solution, the positional force of the piston of the chemical syringe installed, determines the amount of chemical in the chemical syringe, and operates the attached chemical syringe from the chemical syringe. Inject chemicals.
  • the chemical solution filling and injection system determines the chemical solution injection conditions based on the above-described detection conditions and the amount of the chemical solution in the chemical solution syringe.
  • the chemical liquid injecting apparatus obtains the amount of the chemical liquid in the chemical liquid syringe from the position of the piston of the chemical liquid syringe attached. Then, the injection condition of the chemical solution is determined based on the test conditions of the subject and the amount of the chemical solution in the chemical syringe. The amount of the chemical solution filled in the syringe is equal to the amount of the chemical solution filled with the chemical solution filling device according to the test conditions of the subject, and further equal to the injection amount of the chemical solution with the chemical solution injection device .
  • the chemical injection device since the amount of the chemical liquid filled in the chemical liquid syringe is obtained from the piston position of the chemical liquid syringe attached, the determined injection condition is filled in the chemical liquid syringe that is attached.
  • the injection conditions correspond to the amount of the drug solution.
  • the medicinal solution injecting device includes a holding unit that holds a cylinder, a drive mechanism that operates a medicinal solution syringe that holds the cylinder in the holding unit, and a medicinal solution injecting device. And an injection control unit for controlling the operation.
  • the drive mechanism has a piston pressing portion that is detachably held and can move in the moving direction of the piston, and the injection control unit has a piston pressing portion that holds the piston. It is preferable to have an injection control unit that obtains the amount of the chemical solution filled in the chemical solution syringe from the position of the piston pressing portion and determines the injection condition based on the obtained chemical solution amount.
  • the chemical liquid injector may further include a linear encoder that detects the position of the piston pressing portion.
  • the chemical liquid filling device includes a filling operation mechanism for operating the chemical liquid syringe to fill the chemical liquid syringe, an input unit for inputting data relating to a test condition by the chemical liquid, and data input from the input unit
  • the calculation unit that calculates the filling amount of the chemical liquid into the chemical syringe based on the above and the filling control unit that controls the filling operation mechanism according to the calculation result in the calculation unit can be provided.
  • the chemical solution filling device is connected to a management server that manages the medical chart information, and this management server holds a part of data necessary for calculating the filling amount of the chemical solution, It is preferable that this data is transmitted from the management server.
  • the chemical solution injection device further determines the injection condition of the chemical solution based on the calculated amount of the chemical solution, and the determined injection condition is determined by the management server. May be configured to transmit to.
  • the management server stores the examination conditions including the infusion profile of the medicinal solution transmitted from the medicinal solution infusion apparatus as part of the chart information, and the medicinal solution filling apparatus further includes the medicinal solution according to the examination conditions transmitted from the management server.
  • the injection conditions are determined, and the determined injection conditions are transmitted to the management server.
  • the injection condition transmitted from the liquid filling device to the management server may be received, and the chemical solution may be injected according to the received injection condition.
  • the injection conditions determined by the chemical solution injection device are the injection conditions corresponding to the amount of chemical solution that is filled in the chemical syringe installed in the chemical solution injection device, thus preventing waste and emptying of the chemical solution. can do
  • FIG. 1 is a diagram showing an overall configuration of a fluoroscopic imaging system according to an embodiment of the present invention.
  • FIG. 2 is a block diagram of the chemical liquid filling device shown in FIG.
  • FIG. 3 is a perspective view showing an appearance of the chemical liquid injector shown in FIG. 1.
  • FIG. 4 is a perspective view showing the appearance of the injection head shown in FIG.
  • FIG. 5A is a plan view showing the piston drive mechanism shown in FIG. 4 together with the chemical syringe.
  • FIG. 5B is a plan view showing the piston drive mechanism shown in FIG. 4 together with the chemical syringe.
  • FIG. 6 is a block diagram of an example of the chemical liquid injector shown in FIG. 1.
  • a medical fluoroscopic image imaging system 1000 which includes a chemical solution injection device 100, a chemical solution filling device 200, and a CT device 300 that is an imaging device. Has been.
  • the chemical solution filling apparatus 200 fills the chemical solution syringe 500 with the chemical solution stored in the chemical solution container 600.
  • the chemical solution injection device 100 injects the chemical solution filled in the chemical solution syringe 500 from the chemical solution syringe 500 to the subject.
  • the chemical solution filling device 200 and the chemical solution injection device 100 constitute a chemical solution filling and injection system.
  • the CT apparatus 300 captures a fluoroscopic image of a subject into which a chemical solution has been injected, and includes an imaging unit 301 that performs imaging and an imaging control unit 302 that controls the operation of the imaging unit 301.
  • the imaging control unit 302 and the chemical solution injection unit 100 are connected so as to communicate with each other.
  • the chemical solution injection device 100, the chemical solution filling device 200, and the CT device 300 are communicably connected to the hospital management server 400.
  • the hospital management server 400 manages medical chart information and has a database of medical chart information including information on subjects.
  • the medicine night syringe 500 includes a cylinder 501, and a piston 502 provided in the cylinder 501 so as to be movable back and forth in the axial direction of the cylinder 501.
  • the cylinder 501 has a conduit portion 501b at one end thereof, and the piston 502 is inserted into the cylinder 501 from the other end which is the end opposite to the one end of the cylinder 501.
  • a cylinder flange 501 a is formed at the other end of the cylinder 501.
  • the piston 502 has a piston flange 502 a at the end opposite to the end inserted into the cylinder 501.
  • FIG. 1 is a block diagram of the chemical liquid filling apparatus 200 shown in FIG. 1 and FIG.
  • the chemical solution syringe 500 is detachably attached, and the chemical solution syringe 500 that is attached is filled with the chemical solution.
  • the amount of the chemical solution that the chemical solution filling device 200 fills the chemical solution syringe 500 is equal to the amount of the chemical solution that is injected into the subject by the chemical solution injection device 100 (see FIG. 1). Therefore, the chemical syringe 500 is filled with an amount of the chemical solution according to the test condition of the subject by the fluoroscopic imaging system 1000, and the filling amount of the chemical solution into the chemical solution syringe 500 varies depending on the test condition of the subject. .
  • the chemical liquid filling apparatus 200 includes a filling control unit 210 that controls the entire operation of the chemical liquid filling apparatus 200, and a filling control unit 210. Based on the command, the filling operation mechanism 220 for operating the liquid syringe 500, the hospital management server 400 (see Fig. 1), the interface 230 for connecting to the data transmission / reception, the human power ⁇ 240, and the display ⁇ B250 And having.
  • Connection between the chemical solution filling device 200 and the hospital management server 400 may be wired or wireless.
  • a cable connector can be used as the interface 230
  • a wireless data communication device can be used as the interface 230.
  • the input unit 240 can be configured with a key switch touch panel or the like, and accepts data input operations by an operator. In the input unit 240, data relating to the inspection conditions used to determine the amount of the chemical solution filled in the chemical syringe 500 is input.
  • the subject data includes, for example, the weight, sex, height, age, and the like of the subject to whom the drug solution filled in the drug syringe 500 is injected.
  • the chemical liquid data includes, for example, the type of chemical liquid to be filled, manufacturer, product number, viscosity, if the chemical liquid is a cosmetic agent, its odor content, and whether other types of physiological saline are used in combination.
  • the power ⁇ .
  • the syringe data includes a unique identification number such as manufacturer, product number, serial number, volume, piston stroke, expiration date (number of times), and usage. Number of times.
  • Examples of imaging conditions include the subject's imaging site, imaging time, and the injection profile of the drug solution. At least some of these data can also be stored in the hospital management server 400.
  • the filling control unit 210 includes a determination unit 211, a calculation unit 212, a filling control unit 213, and a database 214.
  • the determination unit 211 determines whether or not the drug solution syringe 500 is suitable for filling from the data regarding the detection conditions input by the input unit 240 (and the hospital management server 400 via the interface 230).
  • the suitability of the chemical liquid filling means, for example, whether the chemical liquid syringe 500 has exceeded its useful life (number of times), whether the chemical to be filled is a chemical suitable for this inspection, and the chemical liquid syringe. For example, whether the combination of 500 and drug is appropriate. If it is determined as inappropriate as a result of the determination, the filling control unit 210 issues a warning by a buzzer (not shown), a warning lamp (not shown) or the like, and stops the subsequent operation. On the other hand, if it is determined that it is appropriate, the determination unit 211 sends the input data as it is to the calculation unit 212.
  • the calculation unit 212 calculates the filling amount of the chemical solution into the chemical solution syringe 500 based on the sent data.
  • the filling amount of the chemical solution that is, the injection amount of the chemical solution into the subject, is optimal for capturing a good image.
  • Subject factors such as the subject's weight, height, sex, and age, chemical components, chemical properties, etc. It depends on factors such as the imaging site, imaging time, imaging solution profile, etc.
  • contrast media when the drug solution is a contrast medium, one of the important factors for obtaining a good image is the total injection amount of sodo. Contrast media have different odoid concentrations depending on the type, and different types of contrast media have different amounts of sodo contained in the same amount.
  • coefficient data for each imaging region For example, in the case of a contrast agent, iodine-containing concentration data for each type of contrast medium), and physical information such as the body weight and height of the subject.
  • the total injection amount data of the drug corresponding to the above is stored in the database 214.
  • the calculation unit 212 refers to the database 214, and applies the data related to the above-described inspection conditions to a calculation formula determined in advance in consideration of these various factors. Calculate the amount. Note that the calculation procedure of the filling amount of the chemical solution in the calculation unit 212 may be the same as the calculation procedure of the injection amount of the chemical solution in the conventional chemical injection device, so here the specific calculation formulas and calculation methods are described. Omitted.
  • the calculation unit 212 stores the data input from the input unit 240 and the filling amount calculated by the calculation unit 212 in the hospital management server 400 through the interface 230. If these data are already stored at the previous filling, update these data.
  • the filling control unit 213 controls the filling operation mechanism 220 so that the chemical solution 500 is filled with the calculated filling amount.
  • the charging operation mechanism 220 includes a cylinder, a Honoreta, 221 and a piston Honoreda 222.
  • the cylinder holder 221 is formed with an arc-shaped recess on the side surface for receiving the cylinder flange 501a of the chemical syringe 500.
  • the recess is formed in a stepped shape having a placement surface on which the cylinder flange 501a is placed.
  • the cylinder 501 is held by the cylinder holder 221 by placing the cylinder flange 501a so that the conduit portion 501b faces upward on the mounting surface.
  • the piston holder 222 is disposed below the cylinder holder 221, facing the cylinder holder 221 and away from the cylinder holder 221 (arrow A direction) and in the direction approaching the cylinder holder 221 (arrow B). Direction). As with the cylinder holder 221, the piston holder 222 is also formed with a recess on the side surface for receiving the piston 502. The piston 502 is held in the recess in a state where the piston flange 502a is positioned below the piston holder 222 (on the side opposite to the side facing the cylinder holder 221).
  • the piston 502 is pulled out from the cylinder 501 by moving the piston holder 222 in the arrow A direction while holding the cylinder flange 501a and the piston 502. On the other hand, the piston 502 is pushed into the cylinder 501 by moving the piston holder 222 in the arrow B direction.
  • any driving mechanism such as a ball screw mechanism can be used as long as the mechanism can linearly move the piston holder 502.
  • the ball screw shaft is arranged in parallel with the moving direction of the piston holder 502, and the piston holder 502 is fixed to a ball screw nut that is screwed to the ball screw shaft.
  • the piston holder 502 can be moved in the axial direction of the ball screw shaft as the ball screw shaft rotates.
  • a stepping motor can be used as a drive source for the ball screw shaft.
  • the filling amount of the chemical solution into the chemical solution syringe 500 is proportional to the movement amount of the piston 222 relative to the cylinder 221 when the piston 222 is moved in the direction of pulling out the piston 222 from the cylinder 221. Therefore, the filling control unit 213 controls the filling operation mechanism so that the piston holder 222 moves by the movement amount corresponding to the filling amount calculated by the calculation unit 212. As a result, the chemical liquid syringe 500 is filled with the amount of chemical liquid calculated by the calculation unit 212.
  • the chemical liquid filling device 200 has a touch panel 241 that also serves as the input unit 240 and the display unit 250 shown in FIG.
  • the filling control unit 210 has a determination unit 211.
  • the force determination unit 211 is not essential in the present invention. For example, the operator may determine whether or not the chemical syringe 500 and the chemical solution are appropriate, or the function of the determination unit 211 may be incorporated in the calculation unit 212 to determine whether or not the calculation unit 212 is appropriate. Les.
  • the chemical liquid injector 100 will be described with reference to FIG. 3 and FIG.
  • the chemical injection device 100 is connected to an injection head 110 attached to an upper portion of a movable arm 112 connected to a stand 111, and the injection head 110 and a cable 102.
  • an injection control unit 101 has an operation panel 103 as an input unit, a display unit 104, and a hand unit 107 connected by a cable 108, and controls the operation of the entire chemical injection device 100.
  • two concave portions 114 are formed in the head body 113 as holding portions for holding the cylinders 501 so that two chemical syringes 500 can be attached at a time.
  • the head main body 113 is provided with two piston drive mechanisms 130 that are driven independently of each other, corresponding to the respective recesses 114.
  • the piston drive mechanism 130 is configured to hold the piston flange 502a of the piston 502 at its tip.
  • Each recess 114 is formed with a recess 114a that holds the cylinder 501 in a predetermined position by fitting the cylinder flange 501a of the cylinder 501. Thereby, the chemical syringe 500 is held by the cylinder 501 and the piston 502 force S separately.
  • piston drive mechanism 130 will be described with reference to FIGS. 5A and 5B.
  • the piston drive mechanism 130 has a drive rod 134 and a piston pressing part 131 provided at the tip of the drive rod 134.
  • the drive rod 134 is driven by, for example, an ultrasonic motor (not shown) as a drive source, and the piston pressing portion 131 is moved to a head body by a motion transmission mechanism that converts a rotational motion such as a screw mechanism (not shown) into a linear motion. It is moved in the axial direction of the chemical syringe 500 attached to 113.
  • the piston pressing part 131 has a pressing surface 131a at the tip, and the piston 502 can be pressed into the cylinder 501 by pressing the piston flange 502a of the piston 502 of the chemical syringe 500 with the pressing surface 131a.
  • the piston pressing portion 131 is provided with a pair of flange holding claws 132 that detachably hold the piston 502 by engaging with the piston flange 502a.
  • the flange holding claws 132 are arranged to face each other while protruding from the pressing surface 131a.
  • the flange holding pawl 132 is provided so as to be rotatable about the support shaft 135 in a direction in which the piston flange 502a is engaged and released, that is, a direction in which the flange is held open and closed. It is. In FIG. 5A, the flange holding pawl 132 is also urged in a direction to engage with the piston flange 502a by a panel (not shown) as an urging member.
  • the piston pressing part 131 is provided with a load cell 133.
  • a part of the load cell 133 protrudes from the pressing surface 131a of the piston pressing part 131, and the piston pressing part 131 moves forward to come into contact with the piston flange 502a.
  • the flange holding claw 132 itself may be configured by a member that elastically deforms.
  • the number of flange holding claws 132 may be one or three or more as long as the piston pressing portion 131 can force the piston flange 502a to be detachable.
  • the chemical solution filled in the chemical syringe 500 is, for example, one of which is a contrast medium and the other is physiological saline.
  • Power S can be.
  • the two chemical syringes 500 attached to the head body 113 are connected by a connecting tube 530.
  • An extension tube (not shown) having a catheter (not shown) connected to the distal end portion is connected to the connection tube 530.
  • the injection control unit 101 includes an injection control unit 121, an injection profile storage unit 122, and a linear encoder 123.
  • the linear encoder 123 detects the position of the piston pressing portion 131 (see FIG. 5A).
  • an optical linear encoder can be used as the linear encoder 123.
  • the present invention is not limited to this, and an arbitrary linear encoder can be used.
  • the linear encoder 123 When the linear encoder 123 is optical, the linear encoder 123 has a linear scale and a detection head.
  • the linear scale is a strip-shaped member fixed to the head body 113 so as to extend along the moving direction of the piston pressing portion 131 in the vicinity of the piston pressing portion 131, and a large number of slits extend in the longitudinal direction of the linear scale. They are formed side by side.
  • the detection head is fixed to the piston pressing part 131 and has a light emitting element and a light receiving element.
  • the linear encoder 123 originally detects the amount of movement of the detection head from a certain position. By setting a certain position as a specific position, the position of the detection head with respect to the specific position is determined. Can be detected. Therefore, by fixing the detection head to the piston pressing portion 131, the linear encoder 123 causes the piston pressing portion 131 to be in the initial position when the piston pressing portion 131 is at the most retracted position. The position of 13 1 can be detected.
  • the infusion profile storage unit 122 stores at least one infusion profile corresponding to the chemical solution. Examples of injection profiles include
  • the rate of change of the injection rate is determined so that the injection of the chemical solution is completed in a predetermined time.
  • Preferred profile with at least one stage having a stage where the injection rate changes with respect to the time elapsed since the start of the injection, eg, contrast agent injection rate From the beginning of the injection to a certain time, and then the profile that keeps or increases the injection rate constant, after which the injection rate of the contrast agent is decreased (eg linearly) in at least one stage, Profiles that increase the rate of saline injection.
  • the injection control unit 121 controls the overall operation of the drug solution injection device 100. As will be described in detail later, based on a signal from the linear encoder 123 and a signal from the load cell 133, the injection control unit 121 The amount of chemical solution filled in is obtained. The injection control unit 121 is based on the calculated amount of medicinal solution and the infusion profile read from the infusion profile storage unit 122 so that a predetermined amount of medicinal solution is injected into the subject at a predetermined time and with a predetermined infusion profile. Determine the injection conditions of the chemical solution. The injection control unit 121 controls the piston drive mechanism 130 so that the piston drive mechanism 130 operates in an operation sequence according to the determined injection condition.
  • the interface 140 connects the chemical solution injection device 100 to the CT device 300 and the hospital management server 400 (both see Fig. 1) so as to be communicable, and injects the chemical solution determined by the injection control unit 121.
  • the condition is transmitted to the CT apparatus 300 and the hospital management server 400 via the interface 140.
  • the data is transmitted from the hospital management server 400 to the injection control unit 121 via the interface 140.
  • the CT apparatus 300 force and other information are also transmitted to the injection control unit 121 via the interface 140.
  • the operation panel 123 has an injection start button.
  • the injection control unit 121 actually operates the piston drive mechanism 130.
  • the operation panel 103 further includes a profile selection button, and the operator can select one of the injection profiles. It ’s like that.
  • the operator prepares an empty chemical solution syringe 500, that is, a chemical solution syringe 500 that is not filled with a chemical solution, and a chemical solution container 600 that stores the chemical solution to be filled in the chemical solution syringe 500.
  • the chemical syringe 500 is in a state where the piston 502 is pushed most into the cylinder 501. It is assumed that the chemical solution injection device 100, the chemical solution filling device 200, the CT device 300, and the like constituting the fluoroscopic image system 1000 are already prepared.
  • the operator attaches the prepared empty chemical solution syringe 500 to the chemical solution filling apparatus 200 with the conduit portion 501b facing up. After the chemical solution syringe 500 is attached, the operator connects the chemical solution container 600 and the chemical solution syringe 500 with the tube 610.
  • the operator determines the filling amount of the chemical liquid into the chemical syringe 500 as described above.
  • Data necessary for the operation is input from the touch panel 241 of the chemical filling device 200. Some of the necessary data may be transmitted from the hospital management server 400 via the interface 230.
  • the chemical liquid filling device 200 determines whether or not the chemical liquid syringe 500 is appropriately charged. As a result, if it is determined to be appropriate, the chemical liquid filling device 200 calculates the filling amount of the chemical liquid into the chemical syringe 500 using the obtained data, and stores the chemical liquid syringe 500 according to the calculation result. Fill with chemicals.
  • the chemical solution filling apparatus 200 After filling the chemical solution, the chemical solution filling apparatus 200 transmits the data input from the touch panel 241 and the calculated filling amount data to the hospital management server 400 via the interface 230.
  • the operator When the data transmission is completed, the operator removes the chemical solution syringe 500 filled with the chemical solution from the chemical solution filling device 200 and attaches it to the injection head 110 of the chemical solution injection device 100.
  • the operator connects the extension tube to the chemical syringe 500 via the connection tube 530 (directly when only one chemical syringe 500 is attached), and is provided at the tip of the extension tube. A catheter is inserted into the subject.
  • the chemical syringe 500 is attached to the injection head 110 as follows.
  • the piston pressing portion 131 Before the chemical syringe 500 is mounted, the piston pressing portion 131 is in the initial position. In this state, the cylinder 501 of the chemical syringe 500 is held in the recess 114 of the injection head 110. The chemical syringe 500 is filled with a chemical solution, and the piston 502 protrudes from the cylinder 501. However, since the piston pressing portion 131 is in the initial position, the piston pressing portion 131 moves away from the piston flange 502b force.
  • the injection control unit 121 drives the piston drive mechanism 130 to advance the piston pressing unit 131 toward the piston flange 502a.
  • This operation can be performed using a command from the operation panel 103 by the operator or a detection signal for attaching the chemical syringe 500 to the injection head 110 by a sensor (not shown) as a trigger.
  • the mounting of the chemical syringe 500 to the injection head 110 is completed.
  • the linear encoder 123 sends the position information of the piston pressing unit 131 to the injection control unit 121.
  • the injection control unit 121 obtains the amount of the drug solution filled in the drug solution syringe 500 based on the position information of the linear encoder 123 force.
  • the cylinder 501 of the chemical syringe 500 is held at a predetermined position of the injection head 110. Accordingly, the position of the piston pressing portion 131 that holds the piston flange 502a corresponds to the amount of protrusion of the piston 502 from the cylinder 501.
  • the amount of protrusion of the piston of the cylinder 50 1 force 502 is proportional to the amount of the chemical liquid filled in the chemical syringe 500.
  • the amount of the chemical liquid filled in the chemical syringe 500 is proportional to the square of the inner diameter of the cylinder 501, but the chemical syringe 500 that can be attached to the injection head 110 conforms to the recess 114, so The inner diameter of the cylinder 501 is determined. Therefore, the amount of the chemical solution in the chemical solution syringe 500 can be obtained from the position of the piston pressing portion 131.
  • the chemical syringe 500 may be mounted using an adapter (not shown). In such a case, for example, by inputting the product number of the chemical syringe 500 from the operation panel 103 and multiplying a predetermined coefficient corresponding to the outer diameter of the chemical syringe 500 in the process of obtaining the chemical amount, the outer diameter is reduced. The amount of the chemical solution can be obtained for different chemical syringes 500.
  • the processing for determining the amount of the chemical solution in the chemical syringe 500 may be performed entirely by the injection control unit 121.
  • the relationship between the position of the piston pressing portion 131 and the amount of the chemical solution is prepared in advance in the injection control unit 101 as a database (not shown), and the injection control unit 122 obtains the relationship by referring to this database. May be.
  • Chemical injection device 100 Is a sequence of operations of the piston drive mechanism 130 so that a chemical solution is injected according to a predetermined injection profile determined in advance or an injection profile selected by the operator based on the amount of the chemical solution obtained by the injection control unit 121 ( Determine the injection conditions).
  • the operator When the injection condition of the chemical solution is determined, the operator operates the injection start button of the input unit 123. Thereby, the injection control unit 121 operates the piston pressing unit 131 of the piston drive mechanism 130 according to the determined injection condition, and the chemical solution in the chemical solution syringe 500 is injected into the subject.
  • a signal is sent from the injection control unit 101 force to the imaging control unit 302 of the CT apparatus 300 via the interface 140, and the imaging unit based on the control signal from the imaging control unit 302 301 captures a fluoroscopic image of the subject.
  • An image picked up by the CT apparatus 300 is sent to the hospital management server 400 directly or via the drug solution injector 100.
  • the hospital management server 400 records the CT examination result in the database.
  • the injection control unit 101 of the drug solution injection apparatus 100 transmits the injection condition of the drug solution to the hospital management Sano 400 via the interface 140. Therefore, in the database of the hospital management server 400, the injection condition of the chemical solution is recorded together with the CT test result.
  • CT imaging condition data (exposure conditions such as radiation dose and radiation exposure timing) is transmitted from the CT apparatus 300 to the chemical injection device 100 via the interface 140, and the chemical injection device 100 is connected to the hospital.
  • the imaging condition data described above may be added as data to be transmitted to the management Sano 400.
  • the CT imaging condition data may be transmitted directly from the CT apparatus 300 to the hospital management server 400.
  • the chemical liquid filling device 200 calculates the filling amount of the chemical liquid into the chemical syringe 500 using the data related to the inspection conditions, and the chemical syringe 500 is filled with the necessary amount of the chemical liquid. Therefore, the waste of chemicals can be eliminated.
  • chemical solution injector 100 obtains the amount of chemical solution filled in chemical solution syringe 500 from the position of piston 502 of chemical solution syringe 500 attached. Therefore, it is not necessary for the chemical injection device 100 to calculate the injection amount of the chemical solution. Therefore, the operator does not need to input data necessary to calculate the injection amount into the chemical injection device 100. As a result, the operator The work burden can be greatly reduced.
  • the injection condition of the chemical liquid in the chemical liquid injection apparatus 100 is that the piston 502 of the chemical liquid syringe 500 attached to the chemical liquid injection apparatus 100 is located at the position of the piston pressing part 131 when the piston 502 is held by the piston pressing part 131. Has been determined based on.
  • the position of the piston pressing portion 131 corresponds to the position of the piston 502, in other words, the amount of the chemical liquid filled in the chemical liquid syringe 500. Therefore, the chemical solution injection device 100 reliably determines the injection condition of the chemical solution based on the amount of the chemical solution filled in the chemical solution syringe 500 actually attached to the chemical solution injection device 100, and the chemical solution is used under the injection condition. Can be injected. As a result, it is possible to prevent the waste or empty shot of the chemical when the chemical is injected into the subject.
  • the medical solution filling apparatus 200 and the hospital management server 400 are connected so that data can be transmitted and received so that the result of filling the chemical solution can be transmitted to the hospital management server 400.
  • data can be transmitted and received so that the result of filling the chemical solution can be transmitted to the hospital management server 400.
  • a part of the data required to determine the amount of liquid medicine to be filled in the liquid medicine syringe 500 is recorded in the hospital management Sanoku 400 database. Data input work can be reduced.
  • Data that can be prepared as a database is data that can be specified from data when the data is known.
  • data that can be specified from data when the data is known.
  • the unique identification number for example, product number and serial number
  • other data can be identified from the unique identification number.
  • the unique identification number for example, product number and lot number
  • other data can be identified from the unique identification number.
  • the medical liquid filling apparatus 200 or the chemical liquid injection apparatus 100 that is not included in the hospital management server 400 may have a data base in which data that can be specified from such a unique identification number is recorded.
  • the hospital management server 400 records not only the data related to the subject but also the data related to each equipment such as the chemical solution injection device 100, the chemical solution filling device 200, and the CT device 300. Management becomes possible.
  • the chemical liquid filling amount by the chemical liquid filling device 200 is obtained by the calculation in the calculation unit 212.
  • the database 214 is used for each detection input to the filling control unit 210.
  • the calculation unit 212 Therefore, the filling amount of the chemical solution can be obtained simply by referring to the database 214 instead of the calculation.
  • the piston drive mechanism 130 uses a pulse-driven motor such as an ultrasonic motor as a drive source, the pulse applied to the motor while the piston pressing unit 131 moves from the initial position until the piston 502 is held.
  • the position of the piston pressing part 131 can also be detected by counting the number.
  • the linear encoder 123 is unnecessary.
  • the chemical injection device 100 determines the injection condition of the chemical.
  • the chemical injection device 100 and the chemical filling device 200 can communicate data with the hospital management server 400.
  • the chemical filling device 200 can determine the injection conditions.
  • the hospital management server 400 holds the examination condition as part of the chart information.
  • the inspection condition includes an injection profile of the chemical solution transmitted from the chemical solution injection device 100.
  • the chemical filling device 200 receives the inspection conditions from the hospital management server 400 when the chemical syringe 500 is filled with the chemical liquid. Based on the received inspection conditions, the chemical liquid filling device 200 Determine injection conditions. The obtained injection conditions are transmitted to the hospital management server 400.
  • the chemical liquid syringe 500 that has been filled with the chemical liquid is transferred from the chemical liquid filling apparatus 200 to the chemical liquid injection apparatus 100. Thereafter, the injection condition of the chemical solution is transmitted from the hospital management server 400 to the chemical solution injection device 100, and the chemical solution injection device 100 injects the chemical solution according to the injection condition received from the hospital management server 400.
  • the amount of the chemical solution filled in the chemical solution syringe 500 attached to the chemical solution injection device 100 is obtained by the chemical solution injection device 100.
  • the data sent from the hospital management server 400 is actually Whether or not the liquid syringe 500 is attached to the liquid injector 100 is determined by comparing the injection conditions transmitted from the hospital management server 400 with the amount of liquid determined by the liquid injector 100. can do.
  • the chemical solution injection device 100 has a plurality of types of injection profiles, and it may be desired to change the injection profile used when determining the injection conditions in the chemical solution filling device 200. If the injection profile is changed, the conditions for injecting the drug solution may also change. Therefore, in this case, before injecting the chemical solution, the injection profile is set again in the chemical injection device 100, and the chemical injection device 100 sets the injection condition transmitted from the hospital management server 400 according to the injection profile set again. To be able to change
  • the force described by taking the X-ray CT apparatus as an example of the imaging apparatus.
  • the present invention can be applied to an MRI apparatus, PET apparatus, ultrasonic diagnostic apparatus, CT angio apparatus, MRA apparatus, etc. The same can be applied.
  • a contrast medium or physiological saline suitable for each can be used as the chemical solution.
  • hospital management systems include the medical information system “HIS” (Hospital Information System) that accepts and accounts for outpatients, and the radiological information system “RIS” (Radiology) in the radiation department.
  • HIS Medical Information System
  • RIS Radiological information system
  • the HIS is an administrative system for image data server management, reception work, and medical expenses
  • the RIS is a system for radiological examination and medical care.
  • the hospital management server is preferably a part of any of these HIS, RIS, and in-hospital information systems that link these.

Abstract

L'invention concerne un système de remplissage et d'injection de liquide chimique comprenant un dispositif de remplissage de liquide chimique (200) et un dispositif d'injection de liquide chimique (100). Le dispositif de remplissage de liquide chimique (200) permet d'obtenir, en fonction des conditions d'examen d'un sujet, la quantité de remplissage d'un liquide chimique acheminé dans une seringue de liquide chimique (500) et il sert à remplir la seringue avec le liquide chimique. La seringue (500) remplie avec le liquide chimique est rattachée au dispositif d'injection de liquide chimique (100), et le dispositif d'injection détermine les conditions d'injection du liquide chimique sur la base de la quantité de liquide chimique se trouvant dans la seringue (500), cette quantité étant obtenue à partir de la position du piston (502) de la seringue (500). Le liquide chimique est injecté de la seringue (500) par le biais de son fonctionnement selon les conditions d'injection déterminées.
PCT/JP2007/063587 2006-07-06 2007-07-06 Système de remplissage et d'injection de liquide chimique WO2008004669A1 (fr)

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JP2008523760A JPWO2008004669A1 (ja) 2006-07-06 2007-07-06 薬液充填注入システム

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JP2006186589 2006-07-06
JP2006-186589 2006-07-06

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012165935A2 (fr) * 2011-06-01 2012-12-06 Castaneda Jr Rogelio Dispositif et procédé de remplissage de seringues
JP2016026628A (ja) * 2015-09-16 2016-02-18 株式会社根本杏林堂 注入機器及び超音波モータの制御方法
US9545646B2 (en) 2011-06-14 2017-01-17 Nemoto Kyorindo Co., Ltd. Injector and control method for an ultrasonic motor
JP2018047257A (ja) * 2017-11-02 2018-03-29 株式会社根本杏林堂 注入機器及び超音波モータの制御方法
JP2020511722A (ja) * 2017-03-15 2020-04-16 ノバルティス アーゲー 医薬品を使用するためのシステム

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JP2003528698A (ja) * 2000-04-04 2003-09-30 アシスト メディカル システムズ， インコーポレイテッド 血管造影剤注入器サブアッセンブリ
JP2004248734A (ja) * 2003-02-18 2004-09-09 Nemoto Kyorindo:Kk 薬液注入装置
JP2004313579A (ja) * 2003-04-18 2004-11-11 Nemoto Kyorindo:Kk 薬液充填装置
JP2005021431A (ja) * 2003-07-03 2005-01-27 Nemoto Kyorindo:Kk 薬液注入システム

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JP2003528698A (ja) * 2000-04-04 2003-09-30 アシスト メディカル システムズ， インコーポレイテッド 血管造影剤注入器サブアッセンブリ
JP2004248734A (ja) * 2003-02-18 2004-09-09 Nemoto Kyorindo:Kk 薬液注入装置
JP2004313579A (ja) * 2003-04-18 2004-11-11 Nemoto Kyorindo:Kk 薬液充填装置
JP2005021431A (ja) * 2003-07-03 2005-01-27 Nemoto Kyorindo:Kk 薬液注入システム

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012165935A2 (fr) * 2011-06-01 2012-12-06 Castaneda Jr Rogelio Dispositif et procédé de remplissage de seringues
WO2012165935A3 (fr) * 2011-06-01 2013-04-04 Castaneda Jr Rogelio Dispositif et procédé de remplissage de seringues
US9545646B2 (en) 2011-06-14 2017-01-17 Nemoto Kyorindo Co., Ltd. Injector and control method for an ultrasonic motor
US11303227B2 (en) 2011-06-14 2022-04-12 Nemoto Kyorindo Co., Ltd. Injector and control method for an ultrasonic motor
JP2016026628A (ja) * 2015-09-16 2016-02-18 株式会社根本杏林堂 注入機器及び超音波モータの制御方法
JP2020511722A (ja) * 2017-03-15 2020-04-16 ノバルティス アーゲー 医薬品を使用するためのシステム
US11355225B2 (en) 2017-03-15 2022-06-07 Novartis Ag System for use of a pharmaceutical product
JP7203750B2 (ja) 2017-03-15 2023-01-13 ノバルティス アーゲー 医薬品を使用するためのシステム
JP2018047257A (ja) * 2017-11-02 2018-03-29 株式会社根本杏林堂 注入機器及び超音波モータの制御方法

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