WO2012142211A1 - Methods and devices for use of degassed fluids with fluid enhanced ablation devices - Google Patents

Methods and devices for use of degassed fluids with fluid enhanced ablation devices Download PDF

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Publication number
WO2012142211A1
WO2012142211A1 PCT/US2012/033203 US2012033203W WO2012142211A1 WO 2012142211 A1 WO2012142211 A1 WO 2012142211A1 US 2012033203 W US2012033203 W US 2012033203W WO 2012142211 A1 WO2012142211 A1 WO 2012142211A1
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WO
WIPO (PCT)
Prior art keywords
fluid
elongate body
gas
inner lumen
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/033203
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English (en)
French (fr)
Other versions
WO2012142211A9 (en
Inventor
Michael G. Curley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thermedical Inc
Original Assignee
Thermedical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2012242845A priority Critical patent/AU2012242845A1/en
Priority to CN201280028612.0A priority patent/CN103619275B/zh
Priority to KR1020137030025A priority patent/KR102061901B1/ko
Priority to ES12771601T priority patent/ES2892774T3/es
Priority to JP2014505263A priority patent/JP6189826B2/ja
Priority to EP21191571.5A priority patent/EP3932347A1/en
Priority to BR112013026126A priority patent/BR112013026126A2/pt
Priority to KR1020197038391A priority patent/KR102212427B1/ko
Application filed by Thermedical Inc filed Critical Thermedical Inc
Priority to EP12771601.7A priority patent/EP2696788B1/en
Publication of WO2012142211A1 publication Critical patent/WO2012142211A1/en
Anticipated expiration legal-status Critical
Publication of WO2012142211A9 publication Critical patent/WO2012142211A9/en
Priority to AU2016250432A priority patent/AU2016250432B2/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/08—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by means of electrically-heated probes
    • A61B18/082—Probes or electrodes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B17/32—Surgical cutting instruments
    • A61B17/3203—Fluid jet cutting instruments
    • A—HUMAN NECESSITIES
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    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A—HUMAN NECESSITIES
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    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1477—Needle-like probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/16—Indifferent or passive electrodes for grounding
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B17/00—Pumps characterised by combination with, or adaptation to, specific driving engines or motors
    • F04B17/03—Pumps characterised by combination with, or adaptation to, specific driving engines or motors driven by electric motors
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B41/00—Pumping installations or systems specially adapted for elastic fluids
    • F04B41/02—Pumping installations or systems specially adapted for elastic fluids having reservoirs
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • A61B2018/00029—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids open
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577—Ablation
    • A—HUMAN NECESSITIES
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    • A61B2018/00642—Sensing and controlling the application of energy with feedback, i.e. closed loop control
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    • A61B2018/00744—Fluid flow
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    • A61B2018/00797—Temperature measured by multiple temperature sensors
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    • A61B2018/00809—Temperature measured thermochromatically
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    • A61B2018/00773—Sensed parameters
    • A61B2018/00791—Temperature
    • A61B2018/00821—Temperature measured by a thermocouple
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    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B2018/044—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating the surgical action being effected by a circulating hot fluid
    • A61B2018/046—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating the surgical action being effected by a circulating hot fluid in liquid form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
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    • A61B2018/1405—Electrodes having a specific shape
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    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
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    • A61B2018/1472—Probes or electrodes therefor for use with liquid electrolyte, e.g. virtual electrodes
    • A—HUMAN NECESSITIES
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    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
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    • A61B18/14—Probes or electrodes therefor
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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
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    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/04—Pumps having electric drive
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
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    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B49/00—Control, e.g. of pump delivery, or pump pressure of, or safety measures for, machines, pumps, or pumping installations, not otherwise provided for, or of interest apart from, groups F04B1/00 - F04B47/00
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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
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    • F04C—ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT PUMPS
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T29/49002—Electrical device making
    • Y10T29/49082—Resistor making
    • Y10T29/49085—Thermally variable

Definitions

  • Fluid can be urged from the fluid reservoir 112, into the degassing apparatus 119 if provided, and into the inner lumen 106 by a pump 116.
  • the pump 116 can be a syringe-type pump that produces a fixed volume flow with advancement of a plunger (not shown).
  • An example of such a pump is a Model 74900 sold by Cole-Palmer Corporation of Chicago, IL.
  • Other types of pumps, such as a diaphragm pump, may also be employed.
  • Gas can be removed from the fluid in a variety of ways, some of which are described in greater detail below. These methods include degassing using one or more chemicals, boiling the fluid, exposing the fluid to a vacuum, and exposing the fluid to a gas having a desired gas concentration. While methods to remove gas from the fluid can be applied to remove substantially all of the gas within the fluid, in some embodiments it can be desirable to maintain some of the gas in the fluid. For example, in some instances it may be desirable to maintain some level of oxygen in the fluid or some level of carbon dioxide in the fluid. By way of non-limiting example, in one embodiment, it can be desirable to degas a fluid to a partial pressure of oxygen (0 2 ) in a range of about 20 mm to about 40 mm of mercury.
  • An additional method for degassing a fluid includes exposing the fluid to a vacuum source, i.e., applying a vacuum to the fluid. Similar to boiling, applying a vacuum to a fluid can be effective to remove a portion of all gases within the fluid. While exemplary apparatuses for applying a vacuum to fluid are described in greater detail below, including apparatuses such as mass exchangers, a vacuum source can generally draw gas from the fluid by reducing the atmospheric pressure surrounding the fluid, thereby drawing gas out of solution by equilibration forces.
  • the fluid can be in a chamber and a vacuum source can be coupled to the chamber so that the vacuum source can apply a vacuum to the fluid within the chamber.
  • Fluid degassing can be performed at a number of different times in conjunction with fluid enhanced ablation therapy.
  • the fluid can be degassed prior to delivering the fluid into a reservoir.
  • the fluid can be degassed and then inserted into the fluid reservoir. Fluid degassed prior to introduction into the fluid reservoir can be sealed in an airtight container to prevent gas from reentering into solution.
  • the fluid can be degassed while in the fluid reservoir.
  • a fluid reservoir containing fluid that is at least partially degassed can be provided in a sterile container and/or can be pre-packaged in sterile packaging. The container can then be coupled to a fluid enhanced ablation therapy system.
  • exemplary apparatuses can include a container or chamber in which the fluid is disposed and the degassing methods discussed above applied directly thereto (e.g., applying a chemical, vacuum, or gas to the chamber and/or heating the chamber as described above), or the apparatus can be more elaborate, such as a mass exchanger.
  • An exemplary mass exchanger is the Cell-Pharm ® Hollow-Fiber Oxygenator manufactured by CD Medical.
  • FIGS. 5-7 One exemplary embodiment of an apparatus 310 for use in degassing fluid is illustrated in FIGS. 5-7.
  • degassed fluid can also be utilized with other types of ablation procedures.
  • unheated degassed fluid can be introduced through a conventional shower-head ablation electrode that is configured to contact, but not penetrate, a treatment volume.
  • the use of a degassed fluid can still be advantageous when utilizing unheated fluid because the fluid can still experience heating in the vicinity of the ablation element.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Plasma & Fusion (AREA)
  • Physics & Mathematics (AREA)
  • Otolaryngology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Surgical Instruments (AREA)
  • Cardiology (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Degasification And Air Bubble Elimination (AREA)
  • External Artificial Organs (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PCT/US2012/033203 2011-04-12 2012-04-12 Methods and devices for use of degassed fluids with fluid enhanced ablation devices Ceased WO2012142211A1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
BR112013026126A BR112013026126A2 (pt) 2011-04-12 2012-04-12 métodos e dispositivos para uso de fluidos desgaseificados com dispositivos de ablação otimizada por fluido
KR1020137030025A KR102061901B1 (ko) 2011-04-12 2012-04-12 유체 증강 절제 장치와 함께 가스제거된 유체를 사용하기 위한 방법 및 장치
ES12771601T ES2892774T3 (es) 2011-04-12 2012-04-12 Dispositivos para el uso de fluidos desgasificados con dispositivos de ablación mejorados con fluido
JP2014505263A JP6189826B2 (ja) 2011-04-12 2012-04-12 アブレーションシステム、アブレーションシステムの作動方法及び液体
EP21191571.5A EP3932347A1 (en) 2011-04-12 2012-04-12 Devices for use of degassed fluids with fluid enhanced ablation devices
AU2012242845A AU2012242845A1 (en) 2011-04-12 2012-04-12 Methods and devices for use of degassed fluids with fluid enhanced ablation devices
CN201280028612.0A CN103619275B (zh) 2011-04-12 2012-04-12 用于对流体增强型消融装置使用除气流体的方法和装置
KR1020197038391A KR102212427B1 (ko) 2011-04-12 2012-04-12 유체 증강 절제 장치와 함께 가스제거된 유체를 사용하기 위한 방법 및 장치
EP12771601.7A EP2696788B1 (en) 2011-04-12 2012-04-12 Devices for use of degassed fluids with fluid enhanced ablation devices
AU2016250432A AU2016250432B2 (en) 2011-04-12 2016-10-27 Methods and devices for use of degassed fluids with fluid enhanced ablation devices

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161474574P 2011-04-12 2011-04-12
US61/474,574 2011-04-12

Publications (2)

Publication Number Publication Date
WO2012142211A1 true WO2012142211A1 (en) 2012-10-18
WO2012142211A9 WO2012142211A9 (en) 2013-11-21

Family

ID=47006969

Family Applications (5)

Application Number Title Priority Date Filing Date
PCT/US2012/033203 Ceased WO2012142211A1 (en) 2011-04-12 2012-04-12 Methods and devices for use of degassed fluids with fluid enhanced ablation devices
PCT/US2012/033213 Ceased WO2012142217A1 (en) 2011-04-12 2012-04-12 Devices and methods for remote temperature monitoring in fluid enhanced ablation therapy
PCT/US2012/033327 Ceased WO2012142291A1 (en) 2011-04-12 2012-04-12 Devices and methods for shaping therapy in fluid enhanced ablation
PCT/US2012/033332 Ceased WO2012142296A1 (en) 2011-04-12 2012-04-12 Methods and devices for controlling ablation therapy
PCT/US2012/033216 Ceased WO2012142219A1 (en) 2011-04-12 2012-04-12 Methods and devices for heating fluid in fluid enhanced ablation therapy

Family Applications After (4)

Application Number Title Priority Date Filing Date
PCT/US2012/033213 Ceased WO2012142217A1 (en) 2011-04-12 2012-04-12 Devices and methods for remote temperature monitoring in fluid enhanced ablation therapy
PCT/US2012/033327 Ceased WO2012142291A1 (en) 2011-04-12 2012-04-12 Devices and methods for shaping therapy in fluid enhanced ablation
PCT/US2012/033332 Ceased WO2012142296A1 (en) 2011-04-12 2012-04-12 Methods and devices for controlling ablation therapy
PCT/US2012/033216 Ceased WO2012142219A1 (en) 2011-04-12 2012-04-12 Methods and devices for heating fluid in fluid enhanced ablation therapy

Country Status (9)

Country Link
US (20) US9138287B2 (enExample)
EP (8) EP3932347A1 (enExample)
JP (15) JP6170037B2 (enExample)
KR (9) KR102061901B1 (enExample)
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