EP0566725B1 - Ablation electrode with insulated temperature sensing elements - Google Patents

Ablation electrode with insulated temperature sensing elements Download PDF

Info

Publication number
EP0566725B1
EP0566725B1 EP92924320A EP92924320A EP0566725B1 EP 0566725 B1 EP0566725 B1 EP 0566725B1 EP 92924320 A EP92924320 A EP 92924320A EP 92924320 A EP92924320 A EP 92924320A EP 0566725 B1 EP0566725 B1 EP 0566725B1
Authority
EP
European Patent Office
Prior art keywords
temperature
electrode
tissue
means
sensing means
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP92924320A
Other languages
German (de)
French (fr)
Other versions
EP0566725A4 (en
EP0566725A1 (en
Inventor
Stuart D. Edwards
Roger A. Stern
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Ltd Barbados
Original Assignee
Boston Scientific Ltd Barbados
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US79057891A priority Critical
Priority to US790578 priority
Application filed by Boston Scientific Ltd Barbados filed Critical Boston Scientific Ltd Barbados
Priority to PCT/US1992/009555 priority patent/WO1993008755A1/en
Publication of EP0566725A1 publication Critical patent/EP0566725A1/en
Publication of EP0566725A4 publication Critical patent/EP0566725A4/en
Application granted granted Critical
Publication of EP0566725B1 publication Critical patent/EP0566725B1/en
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206Generators therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • A61B18/1492Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017Electrical control of surgical instruments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017Electrical control of surgical instruments
    • A61B2017/00022Sensing or detecting at the treatment site
    • A61B2017/00084Temperature
    • A61B2017/00101Temperature using an array of thermosensors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00292Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00292Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means
    • A61B2017/003Steerable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00477Coupling
    • A61B2017/00482Coupling with a code
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053Mechanical features of the instrument of device
    • A61B2018/00059Material properties
    • A61B2018/00089Thermal conductivity
    • A61B2018/00101Thermal conductivity low, i.e. thermally insulating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345Vascular system
    • A61B2018/00351Heart
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345Vascular system
    • A61B2018/00351Heart
    • A61B2018/00357Endocardium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577Ablation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00642Sensing and controlling the application of energy with feedback, i.e. closed loop control
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00666Sensing and controlling the application of energy using a threshold value
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00684Sensing and controlling the application of energy using lookup tables
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00696Controlled or regulated parameters
    • A61B2018/00702Power or energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00773Sensed parameters
    • A61B2018/00779Power or energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00773Sensed parameters
    • A61B2018/00791Temperature
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00773Sensed parameters
    • A61B2018/00791Temperature
    • A61B2018/00797Temperature measured by multiple temperature sensors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00773Sensed parameters
    • A61B2018/00791Temperature
    • A61B2018/00803Temperature with temperature prediction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00773Sensed parameters
    • A61B2018/00791Temperature
    • A61B2018/00815Temperature measured by a thermistor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00773Sensed parameters
    • A61B2018/00827Current
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00773Sensed parameters
    • A61B2018/00869Phase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00773Sensed parameters
    • A61B2018/00875Resistance or impedance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00773Sensed parameters
    • A61B2018/00892Voltage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/0091Handpieces of the surgical instrument or device
    • A61B2018/00916Handpieces of the surgical instrument or device with means for switching or controlling the main function of the instrument or device
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206Generators therefor
    • A61B2018/124Generators therefor switching the output to different electrodes, e.g. sequentially
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206Generators therefor
    • A61B2018/1246Generators therefor characterised by the output polarity
    • A61B2018/1253Generators therefor characterised by the output polarity monopolar
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206Generators therefor
    • A61B2018/1246Generators therefor characterised by the output polarity
    • A61B2018/126Generators therefor characterised by the output polarity bipolar
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/08Accessories or related features not otherwise provided for
    • A61B2090/0803Counting the number of times an instrument is used
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/08Sensors provided with means for identification, e.g. barcodes or memory chips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/60General characteristics of the apparatus with identification means
    • A61M2205/6018General characteristics of the apparatus with identification means providing set-up signals for the apparatus configuration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/60General characteristics of the apparatus with identification means
    • A61M2205/6027Electric-conductive bridges closing detection circuits, with or without identifying elements, e.g. resistances, zener-diodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/70General characteristics of the apparatus with testing or calibration facilities

Abstract

An ablation electrode (16) carries a temperature sensing element (94) for measuring the temperature of the tissue being ablated. A thermal insulating element (88) associated with the sensing element blocks the transfer of heat energy from between the temperature sensing element (94) and the electrode (16). The temperature sensing element therefore measures temperature without being affected by the surrounding thermal mass of the electrode (16).

Description

  • The invention relates to ablation electrodes for ablation catheters that, once steered and manipulated within interior regions of the body, transmit energy to form lesions for therapeutic purposes.
  • Physicians make use of catheters today in medical procedures to gain access into interior regions of the body to ablate targeted tissue areas. It is important for the physician to control carefully and precisely the emission of energy within the body used to ablate the tissue.
  • The need for careful and precise control over the catheter is especially critical during procedures that ablate tissue within the heart. These procedures, called electrophysiological therapy, are becoming more widespread for treating cardiac rhythm disturbances.
  • During these procedures, a physician steers a catheter through a main vein or artery (which is typically the femoral artery) into the interior region of the heart that is to be treated. The physician then further manipulates a steering mechanism to place the ablation electrode carried on the distal tip of the catheter into direct contact with the tissue that is to be ablated, and directs radio frequency energy from the ablation electrode tip through tissue to an indifferent electrode to ablate the tissue and form a lesion.
  • Cardiac ablation especially requires the ability to precisely monitor and control the emission of energy from the ablation electrode.
  • DE-A-3838840 discloses a coagulation device for insertion into tissue and having temperature sensors embedded in quartz sand enclosed in a stainless steel jacket heated by high frequency energy, the sensors being spaced from tissue by the jacket and sand and thermally insulated from tissue by the sand. US-A-4960109 discloses a temperature sensor covered by a material of known ultrasound absorption coefficient.
  • The present invention provides an ablation electrode for transmitting energy to ablate tissue within the heart, the electrode including (a) an energy emitting body for contacting the tissue and for connection to an energy source to transmit energy from such source to ablate the tissue and (b) temperature sensing means; characterised by
       said temperature sensing means being disposed in said body and for making contact with such tissue being ablated to sense the temperature of said tissue, and
       by thermal insulating means between said sensing means and said body and effective to substantially block heat energy transfer between said sensing means and said body during heart tissue ablation by said electrode.
  • The temperature sensing means and thermal insulating means may be in a well in the electrode.
  • The invention provides ablation electrodes and associated apparatus having improved tissue temperature sensing capabilities. The improved temperature sensing capabilities can be used to enhance apparatus control functions based upon tissue temperature.
  • In one embodiment, the ablation electrode carries multiple temperature sensing means and at least one, and preferably each, temperature sensing means is thermally insulated.
  • The thermally insulated temperature sensing means senses true tissue temperature, without being affected by the surrounding thermal mass of the electrode.
  • The ablation electrode according to the invention can be used in ablation apparatus including a radiofrequency generator connected to the electrode for delivering radiofrequency energy to the body, and temperature monitoring means for controlling the generator in response to sensed tissue temperature and changes in sensed tissue temperature. Preferably, the temperature monitoring means in response to changes in sensed tissue temperature generates signals which increase or reduce generator power output to maintain sensed tissue temperature within a preset range and/or generates a signal to interrupt generator power output when sensed tissue temperature falls outside a present range. The temperature monitoring means may include means for displaying tissue temperature values.
  • In the accompanying drawings, tissue ablation electrodes according to the invention are shown in Figs.6 to 8, whilst Figs. 1 to 5 show features of tissue ablation apparatus in which the tissue ablation electrodes according to the invention can be used.
  • Breif Description of the Drawings
  • Fig.1 is a perspective view of tissue ablation apparatus that embodies an ablation electrode according to the invention;
  • Fig.2 is a schematic view of the generator and associated monitor and control circuits for the apparatus;
  • Fig.3 is a schematic view of the power monitor and control circuit for the apparatus;
  • Fig.4 is a schematic view of the tissue impedance monitor and control circuit for the apparatus;
  • Figs. 5A and 5B show schematically the tissue temperature monitor and control circuit for the apparatus;
  • Figs.6A to 6C are views of an ablation electrode according to the invention that can be used in the apparatus of Figs.1 to 5;
  • Figs. 7A to 7C are views of another ablation electrode according to the invention, with multiple thermally insulated temperature sensing means, that can be used in the apparatus of Figs.1 to 5; and
  • Figs.8A to 8C are views of a further ablation electrode according to the invention, specially shaped for use in heart valve regions and having multiple thermally insulated temperature sensing means, that can be used in the apparatus of Fig.sl to 5.
  • Description of the Preferred Embodiments
  • In Fig.1, apparatus 10 for performing ablation on human tissue includes a radiofrequency generator 12 that delivers radiofrequency energy. Apparatus 10 also includes a steerable catheter 14 carrying a radiofrequency emitting ablation electrode 16 according to the invention.
  • In the illustrated embodiment, apparatus 10 operates in a monopolar mode. In this arrangement, it includes a skin patch electrode that serves as an indifferent second electrode 18. In use, the indifferent electrode 18 attaches to the patient's back or other exterior skin area.
  • Alternatively, apparatus 10 can be operated in a bipolar mode. In this mode, the catheter 14 carries both electrodes.
  • In the illustrated embodiment, the ablation electrode 16 and indifferent electrode 18 are made of platinum.
  • In using apparatus 10 to provide cardiac ablation therapy, a physician steers the catheter 14 through a main vein or artery (typically the femoral artery) into the interior region of the heart that is to be treated. The physician then further manipulates the catheter 14 to place the ablation electrode 16 into contact with the tissue within the heart that is targeted for ablation, and directs radio frequency energy from the generator 12 into the ablation electrode 16 to form a lesion on the contacted tissue.
  • In the embodiment shown in Fig. 1, the catheter 14 includes a handle 20, a guide tube 22, and a tip 24 which carries the ablation electrode 16. The handle encloses a steering mechanism 26 for the catheter tip 24. A cable 28 extending from the rear of the handle 20 has plugs (not shown). The plugs connect the catheter 14 to the generator 12 for conveying radiofrequency energy to the ablation electrode 16. The radiofrequency heats the tissue to form the lesion.
  • Left and right steering wires (not shown) extend through the guide tube 22 to interconnect the steering mechanism 26 to the left and right sides of the tip 24. Rotating the steering mechanism 26 to the left pulls on the left steering wire, causing the tip 24 to bend to the left. Also, rotating the steering mechanism 26 to the right pulls on the right steering wire, causing the tip 24 to bend to the right. In this way, the physician steers the ablation electrode 16 into contact with the tissue to be ablated.
  • The generator 12 includes a radiofrequency power source 30 connected through a main isolation transformer 32 to first and second conducting lines 34 and 36.
  • In the illustrated environment, the power source 30 delivers up to 50 watts of power at a frequency of 500 kHz. The first conducting line 34 leads to the ablation electrode 16. The second conducting line 36 leads to the indifferent patch electrode 18.
  • In the ablation electrode according to the invention shown in Figs.6A to 6C, temperature sensing means 84 is carried in the ablation electrode 16; and as Fig.5 shows, apparatus 10 includes temperature monitoring means 82 with control means 86 for the generator 12 that is responsive to the sensed tissue temperature for performing generator control functions.
  • Thermal insulation means 88 thermally isolates the temperature sensing means 84 from the thermal mass of the ablation electrode 16. Thus, the temperature sensing means 84 does not add to or serve as a part of the thermal mass of the ablation electrode 16. It serves to show the true temperature of the tissue with which it is in contact, without adding to the thermal mass of the ablation electrode 16 and without being influenced by the temperature of the surrounding thermal mass of the ablation electrode 16.
  • In the embodiment illustrated in Figs. 6A to C, the ablation electrode 16 includes an interior well 90 at its tip end 92. The temperature sensing means 84 occupies this well.
  • In this arrangement, the thermal insulating means 88 isolates the temperature sensing means 84 from the interior surface of the well 90 and the rest of the thermal mass of the ablation electrode 16.
  • In Figs. 6A to C, the temperature sensing means 84 includes a small bead thermistor 94 with two associated lead wires 96 and 98. The temperature sensing tip of the thermistor 94 is exposed at the tip end 92 of the ablation electrode 16 for tissue contact.
  • The temperature monitoring means 82 includes means for calibrating the thermistor 94 to account for deviations in nominal resistance among different thermistors 94. During manufacture of the catheter 10, the resistance of thermistor 94 is measured at a known temperature, for example, 75 degrees C. A calibration resistor equal to the measured value is incorporated into the catheter handle 20. The leads of the calibration resistor are connected to the temperature monitoring means 82.
  • The thermistor 94 of the type shown is commercially available from the Fanwal Co. (Massachusetts) under the trade designation 111-202CAK-BD1. The lead wires 96 and 98 comprise #36 AWG signal wire Cu+ clad steal (heavy insulation).
  • Potting compound 100 encapsulates the thermistor 94 and lead wires 96 and 98 within the electrode well. Insulating sheathes 102 also shield the encapsulated lead wires 96 and 98. Together, the compound 100 and sheathes 102 electrically insulate the thermistor 94 from the surrounding ablation electrode 16.
  • The potting compound 100 and insulation sheathes 102 can be made with various materials. In the illustrated embodiment, loctite adhesive serves as the potting compound 100, although cyanoacrylate adhesive or RTV adhesive and the like could be used. The sheathes 102 are made from polyimide material, although other conventional electrical insulating materials also can be used.
  • In the illustrated embodiment, the thermal insulating means 88 comprises a tube 104 that envelopes the encapsulated thermistor 94 and lead wires 96 and 98. The thermal insulation tube 104 is itself adhesive bonded to the interior wall of the well 90.
  • The thermal insulating material of the tube 104 can vary. In the illustrated embodiment, it is a polyimide material of wall thickness of about 0.076 mm (.003 inch). Other thermal insulating materials like mylar or kapton could be used.
  • The lead wires 96 and 98 for the thermistor 94 extend from the electrode well 90 through the guide tube 22 and into the catheter handle 20. There, the lead wires 96 and 98 electrically couple to the cable 28 extending from the handle 20. A cable plug (not shown) connects to the generator 12 and transmits the temperature signal from the thermistor 94 to the temperature monitoring means 82.
  • Figs. 7A to C show an alternate embodiment of an ablation electrode 16 having an array of temperature sensing means 84. At least one temperature sensing means 84, and preferably all of them, are thermally isolated from the ablation electrode 16 in the manner shown in Figs 6A to C.
  • As Figs. 7A to C show, the ablation electrode 16 in the multiple array version includes an interior core well 106. Five branch wells 108A to E extend from the core well 106. The branch wells 108A to E open at the surface of the ablation electrode 16. One branch well 108A opens at the tip of the ablation electrode 16, like the single temperature sensing means 84 shown in Figs, 6A to C. The other four branch wells 100B to E extend at an angle from the core well 106 at arcuate intervals of 45 degrees. The four branch wells 108B to E open at the side of ablation electrode 16 and encircle the tip well branch 100A.
  • A temperature sensing means 84 occupies each branch well 108A to E. In the illustrated and preferred embodiment, a thermal insulating means 88 isolates each temperature sensing means 84 from the interior surface of the associated branch well 108A to E and the remaining thermal mass of the ablation electrode 16.
  • As in the embodiment shown in Figs. 6A to c, each thermal sensing means 84 includes a small bead thermistor 94 with two associated lead wires 96 and 98. The temperature sensing tips of the thermistors 94 are exposed at the tip of the ablation electrode 16 for multiple contact with the tissue. The associated lead wires 96 and 98 are bundled vithin the center core well 106 and pass through the guide tube 22 to the handle 20.
  • As in the embodiment shown in Figs. 6A to C, potting compound 100 encapsulates each thermistor 94 and its lead wires 96 and 98 within the associated branch well. insulating sheathes 102 also shield the encapsulated lead wires 96 and 98. Together, the compound 100 and sheathes 102 electrically insulate each thermistor 94 from the surrounding ablation electrode 16.
  • As in the embodiment shown in Figs. 6A to C, a thermal insulating tube 104 envelopes each electrically encapsulated thermistor 94 and its lead wires 96 and 98. And, as in the Figs 6A to C embodiment, adhesive bonds each thermal insulation tube 104 to the interior wall of each branch well 108A to E.
  • Figs. 8A to C show another alternate embodiment of an ablation electrode 16 having multiple temperature sensing means 84.
  • In the arrangement shown in Figs. 8A to C, the ablation electrode 16 includes a forward electrode region 110 and a rear electrode region 112. The forward electrode region 110 and the rear electrode region 112 are generally spherical in shape.
  • An electrical and thermal insulating sleeve 114 separates the forward electrode region 110 and the rear electrode region 112. The sleeve 114 is generally cylindrical in shape. The resulting "peanut" shape is well suited for use within the valve regions of the heart.
  • In the illustrated embodiment, the forward electrode region 110 and the rear electrode region 112 are made of platinum. The sleeve 114 is made of a polysulfone material.
  • Multiple temperature sensing means 84 occupy the surface of each forward and rear electrode region 110 and 112. At least one, and preferably all, the temperature sensing means 84 are thermally isolated from the remainder of the surrounding body of the associated electrode region 110 and 112.
  • Each electrode region 110 and 112 includes an interior core well 116 and branch wells 118 that open at the surface of the associated electrode region 110 and 112. A temperature sensing means 84 occupies each well branch. In the illustrated and preferred embodiment, thermal insulating means 88 also isolates each temperature sensing means 84 from the interior surface of the associated branch well 116 and 118 and the rest of the thermal mass of the electrode region 110 and 112.
  • As in the embodiment shown in Figs. 6A to C, each thermal sensing means 84 includes a small bead thermistor 94 with two associated lead wires 96 and 98. The temperature sensing tips of the thermistors 94 are exposed at the surface of the associated electrode regions 110 and 112 for multiple contact with the tissue. The associated lead wires 96 and 98 are bundled in the center core well 116, passing through the guide tube 22 to the handle 20.
  • As in the previous embodiments, potting compound 100 encapsulates each thermistor 94 and its lead wires 96 and 98 within the associated branch well 116 and 118. Insulating sheathes 102 also shield the encapsulated lead wires 96 and 98. Also as in the previous embodiments, a thermal insulating tube 104 envelopes each electrically encapsulated thermistor 94 and its lead wires 96 and 98. Adhesive bonds the thermal insulation tube 104 to the interior wall of each branch well 116 and 118.
  • The number and arrangement of possible arrays of multiple temperature sensing means 84 can, of course, vary from the specific configurations shown in Figs. 6, 7, and 8. For example, one or more temperature sensing means 84 can occupy the side region of the ablation electrode 16, below its tip. The branch wells holding the temperature sensing means 84 also can extend from the center well at various angles, acute, obtuse, or perpendicular. Not all the temperature sensing means 84 need be thermally isolated from the electrode 16, but preferable they all are.
  • As Fig.5 shows, the temperature monitoring means 82 can perform different display and control functions in response to sensed temperature conditions according to different prescribed criteria.
  • The temperature monitoring means 82 not only responds to sensed tissue temperature in absolute terms but also serves to record changes in tissue temperature over time and respond to these changes as well. The temperature monitoring means 82 includes a control output for each temperature sensing means 84 carried by the associated ablation electrode 16.
  • The lead wires 96 and 98 for each thermistor 94 provide the input for the control outputs 120. Alternatively, when the ablation electrode 16 carries multiple thermistors 94, the number of lead wires 96 and 98 traversing the guide tube 22 can be minimized by providing an integrated circuit within the temperature monitoring means 82 for multiplexing the input signals of the thermistors 94. The temperature monitoring means 82 includes a converter to obtain an average temperature for each grouped array of thermistors 94 during a user prescribed period (which in the illustrated embodinent is about once every 0.01 second).
  • The embodiment shown in Figs. 6A to C includes one thermistor 94, so the input signal and the average will be the same.
  • The embodiment shown in Figs. 7A to C includes a single grouped array of five thermistors 94 clustered at the tip of the ablation electrode 16. For this array, the converter adds the individual input signals and divides by five.
  • The embodiment shown in Figs. 8A to C includes two grouped arrays, one having five thermistors 94 on the forward electrode region 110, the other having four thermistors 94 on the rear electrode region 112. The converter adds the input signals for each grouped array and divides by the associated number of thermistors 94 in each grouped array to obtain an average for the forward electrode region 110 and a separate average for the rear electrode region 112.
  • The temperature monitoring means 82 includes an analog to digital converter, which digitizes the sensed temperature average(s) for the apparatus 10. It also digitizes the value of the calibration resistor The thermistor resistance value is divided by the calibration resistor value to get a normalized resistance for the thermistor 94. This value is the input to a read only memory (ROM) 136 (see Fig. 5B) containing stored thermistor temperature data. The ROM 136 output is the actual measured tissue temperature (in degrees C), taxing into account deviations in the nominal resistance of the thermistor 94.
  • Although not shown in the drawings, the embodiments having multiple thermistors 94 would include an equal number of calibration resistors, one for each thermistor 94.
  • The digital output(s) of the converter can be used to display measurement results. In the illustrated embodiment, apparatus 10 includes a digital display 128 on the generator 12 to show the user the average sensed temperature.
  • If the "peanut" type electrode shown in Figs. 8A to C is used, apparatus 10 includes a separate display for the forward and rear electrode region 110 and 112.
  • The digital output(s) of the converter also can be used to control operation of the generator 12. Preferably, the temperature control signals of the temperature monitoring means 82 also are used to further augment the function of the power and impedance monitoring means 38 and 76 described below.
  • In the illustrated embodiment, apparatus 10 uses the digitized temperature outputs in a feedback loop that maintains radiofrequency output voltage within a desired range or at a constant value to control radiofrequency power at the ablation electrode 16. By controlling the power delivered by the generator 12 based upon temperature, the physician is able to control the size of the lesion generated.
  • For this purpose, apparatus 10 includes an input 130 for the user to enter an operating value desired for the tissue temperature.
  • If tissue temperature remains within a preset range, but deviates a prescribed amount within the range, the temperature monitoring means 82 generates a control signal that either increases or reduces but does not interrupt, the power output. If the tissue temperature rises, the control signal reduces the power output. If the tissue temperature falls, the control signal increases the power output. If measured tissue temperature falls outside the preset range, the temperature monitoring means 82 generates a command signal to shut off power to the ablation electrode 16. A representative set range for tissue temperature for cardiac ablation is believed to be about 40 degrees to 100 degrees C.
  • When temperature begins in the set range and, over time, fall outside it, the most likely cause is the coagulation of blood on the ablation electrode 16, requiring withdrawal and cleaning of the ablation electrode 16. A sudden change in tissue temperature outside the set range suggests a shift in the position of the ablation electrode 16, requiring repositioning of the ablation electrode 16.
  • Apparatus 10 preferably includes flashing lights and an audible alarm (not shown) to transmit a warning to the user when these temperature- based conditions occur.
  • As Figs. 2 and 3 show, apparatus 10 includes power monitoring means 38 for measuring the radiofrequency current and radiofrequency voltage delivered by the generator 12 to the patient. The power monitoring means 38 also derives control signals indicative of RMS (root mean squared) voltage (in volts), RMS current (in amps), and actual phase sensitive power (in watts) to support other control functions of the generator 12.
  • The power monitoring means 38 may be variously configured and constructed. In the illustrated embodiment, includes current monitoring means 40 for measuring the radiofrequency currant passing from the first line 34 through the tissue to the second line 36 (i.e., from the ablation electrode 16 to the indifferent patch electrode 18).
  • The power monitoring means 38 also includes voltage monitoring means 42. The voltage monitoring means 42 measures the radiofrequency voltage generated between the first and second conducting lines 34 and 36 (i.e., between the ablation electrode 16 and the indifferent patch electrode 18).
  • The power monitoring means 38 includes three control outputs 44, 46, and 48.
  • The first control output 44 carries a signal representative of RMS current conducted by the ablation electrode 16.
  • The second control output 46 carries a signal representative of the RMS voltage between the ablation electrode 16 and the indifferent patch electrode 18.
  • The third control output 48 carries a signal representative of actual phase sensitive power transmitted by the ablation electrode 16.
  • In the illustrated embodiment (as Figs. 2 and 3 show), the current monitoring means 40 includes an isolated current sensing transformer 50 connected in the second conducting line 36. In this arrangement, the current sensing transformer 50 directly measures the radiofrequency current passing through the ablation electrode 16 to the indifferent patch electrode 18.
  • The measured value is a radiofrequency signal varying at the selected rate, which in the illustrated embodiment is 500 kHz.
  • The current sensing transformer 50 is connected to the first control output 44, which derives RMS current. The first control output 44 includes an integrated circuit RMS converter 52 to do this function. The RMS current converter first squares the radiofrequency current input signal from the current sensing transformer 50, and then averages the squared signal over a user prescribed, period (which in the illustrated embodiment is about once every 0,01 second) . The RMS currant converter 52 then takes the square root of the average squared value. The resulting output represents RMS current.
  • The RMS current signal takes the form of a relatively slowly varying signal, compared with the rapidly varying radiofrequency current input signal.
  • As Figs. 2 and 3 show, the voltage monitoring means 42 includes an isolated voltage sensing transformer 54 that is connected between the first and second conducting lines. In this arrangement, the voltage sensing transformer 54 directly measures the radiofrequency voltage across the body tissue between the ablation electrode 16 and the indifferent patch electrode 18.
  • Like the value measured by the current sensing transformer 50, the measured voltage value is a radiofrequency signal varying at the selected 500 kHz rate.
  • The voltage sensing transformer 54 is connected to the second control output 46, which derives RMS voltage. The second control output 46 includes an integrated circuit RMS converter 56 to do this function. The RMS voltage converter 56 squares the radiofrequency voltage input signal and then averages it over the same user prescribed period used by the current converter 52. The RMS voltage converter 56 then takes the square root of the average squared voltage value.
  • The resulting RMS voltage signal (like the RMS current signal) takes the form of a relatively slowly varying signal.
  • The voltage sensing transformer 54 is also connected to the third control output 48, which derives actual phase sensitive power. The third control output 48 includes an analog multiplier integrated circuit 58 to do this function. The multiplier circuit 58 receives as one input the radiofrequency input current signal directly from the current sensing transformer 50. The multiplier circuit 58 also receives as a second input the radiofrequency input voltage signal directly from the voltage sensing transformer 54.
  • The output of the multiplier circuit 58 is the product of these two inputs, which represents the actual radiofrequency power transmitted by the ablation electrode 16.
  • The power value is (like its component current and voltage inputs) a radiofrequency signal varying at a relatively high radiofrequency rate.
  • The third control output 48 also includes a low pass filter 60. In the illustrated embodiment, which operates with a radiofrequency rate of 500 kHz, the cut off frequency of the filter 60 selected is about 100 Hz. The rapidly varying measured input power value is low pass filtered by the filter 60 into a relatively slovly varying signal.
  • This signal represents the actual phase sensitive power signal of the radiofrequency energy that the ablation electrode 16 delivers to the targeted tissue.
  • The first, second, and third control outputs 44, 46, and 48 each includes appropriate inline scaling circuits 62. The scaling circuits 62 scale the RMS current signal, the RMS voltage signal, and the actual phase sensitive power signal to a specified voltage range that can be usable by the remainder of generator 12 circuitry. In the illustrated embodiment, the scaled range is 0.0 to 5.0 volts.
  • The power monitoring means 38 also includes an analog to digital converter 64. The converter 64 digitizes a selected one or more of the analog RMS currant output signal, RMS voltage output signal, and the actual phase sensitive power signal.
  • The digital output(s) of the converter 64 can be used to display measurement results. In the illustrated embodiment, the apparatus 10 includes a first digital display 66 on the generator 12 to show the user the actual phase sensitive power signal.
  • The digital output(s) of the converter 64 also can be used to control operation of the generator 12. The illustrated embodiment uses the digitized outputs in a feedback loop that maintains radiofrequency output voltage within a desired range or at a constant value to control radiofrequency power at the ablation electrode 16. By controlling the power delivered by the generator 12, the physician can reproducibly form lesions of the desired depth during an ablation procedure.
  • In this arrangement, apparatus 10 includes, an input 68 for the user to enter an operating value desired for the actual phase sensitive power for the generator 12. It includes power control means 70 that includes comparator 71 to compare desired power with actual phase sensitive power. The output of the comparator varies the output voltage of radiofrequency power source 30 to maintain minimum error between the measured actual power and the set point power.
  • In the illustrated embodiment, the power control means 70 also monitors phase differences between radiofrequency voltage and current. The power control means 70 does this function by computing apparent power and by comparing the computed apparent power to the actual phase sensitive power. If the radiofrequency voltage and current signals are exactly in phase, the apparent power and actual phase sensitive power will be the same. However, if there, is a phase difference, actual phase sensitive power will differ from the apparent power by a factor that represents the cosine of the phase angle.
  • In the illustrated embodiment, the power control means 70 includes a multiplier circuit 72 that obtains the product of the RMS current and RMS voltage. The resulting output of the multiplier circuit 72 forms the apparent (i.e., not phase sensitive) power of the system 10. The power control means 70 includes a comparator 74 to compare the derived apparent power with the actual phase sensitive power. Tha magnitude of the output of the comparator 74 quantifies the amount of the phase shift.
  • If the output of the phase shift comparator 74 exceeds a preselected amount, the power control means 70 generates a warning signal to show that a phase shift between the radiofrequency voltage and current has occurred. The apparatus 10 may include a flashing light and audible alarm (not shown) to warn the user.
  • The power control means 70 operates to maintain a constant set power when the output of the phase shift comparator 74 remains within an allowable range above the threshold amount. The power control means 70 operates to reduce the output voltage of the source 30 when the output of the phase shift comparator 74 increases beyond this range. If the output of the phase shift comparator 74 shows a phase shift beyond a maximum threshold value, the power control means 70 generates a signal to shut off all power to the ablation electrode 16.
  • As Fig. 4 shows, apparatus 10 further includes impedance monitoring means 76 for deriving the impedance of the tissue undergoing ablation. The impedance monitoring means 76 derives tissue impedance not only in absolute terms, but it also serves to record changes in tissue impedance over time.
  • The impedance monitoring means 76 generates appropriate control signals based upon observed absolute values of tissue impedance as well as sensed changes according to preprogrammed criteria.
  • The impedance monitoring means 76 may be variously configured and constructed. In the illustrated embodiment, it includes a microprocessor 78. The microprocessor 78 samples the digitized outputs of the analog-to-digital converter 64 at prescribed intervals (for example, every 20 milliseconds, which represents a 50 Hz sampling rate).
  • The microprocessor 78 also divides the sampled digitized RMS voltage signal by the sampled digitized RMS current signal. The digital result is the tissue impedance (in ohms) for the sample. Preferably, apparatus 10 includes a display 80 on the generator 12 that shows the user the sampled tissue impedance.
  • The microprocessor 78 also maintains a record of sampled tissue impedances over time. From this record, the microprocessor 78 calculates the changes in tissue impedance during a selected interval and generates appropriate control signals based upon predetermined criteria.
  • The predetermined criteria under which the microprocessor 78 generates the control signals based upon tissue impedance can vary. Preferably, the tissue impedance control signals are used to augment the monitoring and control functions of the power control means 70 just described.
  • In the illustrated embodiment, if measured tissue impedance falls outside a predetermined set range, the microprocessor 78 generates a command signal to shut off power to the ablation electrode 16, whatever the actual phase sensitive power level sensed. The set range for tissue impedance for a cardiac ablation procedure is believed to be about 50 to 300 ohms.
  • When tissue impedance begins in the set range and, over time, increases beyond it, the most likely cause is the coagulation of blood on the ablation electrode 16. A sudden rise in tissue impedance over the set range suggests the sudden onset of coagulation or a sudden shift in the position of the ablation electrode 16. Rapid fluctuations of the tissue impedance also could suggest poor contact between the ablation electrode 16 and the targeted tissue. All require prompt response; for example, withdrawal and cleaning of the ablation electrode 16, or repositioning of the ablation electrode 16.
  • Apparatus 10 preferably includes flashing lights and an audible alarm (not shown) to transmit a warning to the user when These conditions occur.
  • A very high tissue impedance value could suggest poor skin contact with the indifferent electrode 18, or an electrical problem. Again, this calls for prompt corrective action.
  • If tissue impedance remains within the set range, but rises beyond a prescribed amount within the range, the second monitoring means 76 generates a control signal that reduces but does not interrupt, the power output. In this arrangement, a relatively tight range of tissue impedance can be established (for example, so to 150 ohms) to maintain relatively constant power within this range.
  • Apparatus 10 as described can provide preoise control over the ablation procedure. The monitoring and control of-actual phase sensitive power assure the effective distribution of radiofrequency to the ablation electrode 16. The monitoring and control of tissue impedance and tissue temperature; either separately or in combination, set safe physiological limits in terms of lesion size and detection of coagulation. Monitoring and control of tissue impedance and/or tissue temperature also provide information regarding orientation of the ablation electrode 16.

Claims (10)

  1. An ablation electrode [16] for transmitting energy to ablate tissue within the heart, the electrode including (a) an energy emitting body for contacting the tissue and for connection to an energy source [12] to transmit energy from such source [12] to ablate the tissue and (b) temperature sensing means; characterised by
       said temperature sensing means [84] being disposed in said body and for making contact with such tissue being ablated to sense the temperature of said tissue, and
       by thermal insulating means [88] between said sensing means and said body and effective to substantially block heat energy transfer between said sensing means and said body during heart tissue ablation by said electrode.
  2. An electrode [16] according to claim 1 wherein said temperature sensing means [84] and thermal insulating means [88] are in a well [90] in said body.
  3. An electrode [16] according to claim 1 or 2 wherein said thermal insulating means [88] comprises a tube [104] formed from insulating material.
  4. An electrode [16] according to any preceding claim including electrical insulator [100] between said temperature sensing means [84] and said thermal insulating means [88].
  5. An electrode [16] according to claim 4 wherein said electrical insulator [100] comprises potting compound.
  6. An electrode [16] according to any preceding claim wherein said temperature sensing means [84] comprises a thermistor [94].
  7. An electrode [16] according to any preceding claim having multiple said temperature sensing means [84] with said thermal insulating means [88] between said body and each, or at least one, of said sensing means.
  8. An electrode [16] according to any preceding claim having a radiofrequency generator [12] connected thereto for delivering radiofrequency energy to said body, and temperature monitoring means [82] for controlling the generator in response to sensed tissue temperature and changes in sensed tissue temperature, said monitoring means [82] optionally including an input [130] for entry of desired operating tissue temperature.
  9. An electrode [16] according to claim 8 wherein said temperature monitoring means [82] in response to changes in sensed tissue temperature generates signals which increase or reduce generator power output to maintain sensed tissue temperature within a preset range and/or generates a signal to interrupt generator power output when sensed tissue temperature falls outside a preset range.
  10. An electrode [16] according to claim 8 or 9 wherein said temperature monitoring means [82] includes means [128] for displaying tissue temperature values.
EP92924320A 1991-11-08 1992-11-05 Ablation electrode with insulated temperature sensing elements Expired - Lifetime EP0566725B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US79057891A true 1991-11-08 1991-11-08
US790578 1991-11-08
PCT/US1992/009555 WO1993008755A1 (en) 1991-11-08 1992-11-05 Ablation electrode with insulated temperature sensing elements

Publications (3)

Publication Number Publication Date
EP0566725A1 EP0566725A1 (en) 1993-10-27
EP0566725A4 EP0566725A4 (en) 1995-02-22
EP0566725B1 true EP0566725B1 (en) 2003-06-04

Family

ID=25151131

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92924320A Expired - Lifetime EP0566725B1 (en) 1991-11-08 1992-11-05 Ablation electrode with insulated temperature sensing elements

Country Status (9)

Country Link
US (3) US5456682A (en)
EP (1) EP0566725B1 (en)
JP (1) JP3530528B2 (en)
AT (1) AT241938T (en)
AU (1) AU3067292A (en)
CA (1) CA2106410C (en)
DE (2) DE69233091T2 (en)
ES (1) ES2201051T3 (en)
WO (1) WO1993008755A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2856935A1 (en) 2013-09-26 2015-04-08 Biotronik AG Medical device for evaluating a temperature signal

Families Citing this family (756)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5540681A (en) * 1992-04-10 1996-07-30 Medtronic Cardiorhythm Method and system for radiofrequency ablation of tissue
US5743904A (en) * 1996-05-06 1998-04-28 Somnus Medical Technologies, Inc. Precision placement of ablation apparatus
US7022105B1 (en) 1996-05-06 2006-04-04 Novasys Medical Inc. Treatment of tissue in sphincters, sinuses and orifices
US5514131A (en) * 1992-08-12 1996-05-07 Stuart D. Edwards Method for the ablation treatment of the uvula
US5645082A (en) * 1993-01-29 1997-07-08 Cardima, Inc. Intravascular method and system for treating arrhythmia
US5699796A (en) * 1993-01-29 1997-12-23 Cardima, Inc. High resolution intravascular signal detection
US5730719A (en) * 1994-05-09 1998-03-24 Somnus Medical Technologies, Inc. Method and apparatus for cosmetically remodeling a body structure
US5817049A (en) * 1994-05-09 1998-10-06 Somnus Medical Technologies, Inc. Method for treatment of airway obstructions
US5707349A (en) * 1994-05-09 1998-01-13 Somnus Medical Technologies, Inc. Method for treatment of air way obstructions
US5743870A (en) * 1994-05-09 1998-04-28 Somnus Medical Technologies, Inc. Ablation apparatus and system for removal of soft palate tissue
US5843021A (en) 1994-05-09 1998-12-01 Somnus Medical Technologies, Inc. Cell necrosis apparatus
US6152143A (en) * 1994-05-09 2000-11-28 Somnus Medical Technologies, Inc. Method for treatment of air way obstructions
US5628771A (en) * 1993-05-12 1997-05-13 Olympus Optical Co., Ltd. Electromagnetic-wave thermatological device
DE4323585A1 (en) * 1993-07-14 1995-01-19 Delma Elektro Med App Bipolar high-frequency surgical instrument
AT255361T (en) * 1993-10-01 2003-12-15 Target Therapeutics Inc Multipolar catheters and multipolar guidewire for measurement of electrical heart activity
US20050288748A1 (en) * 1993-10-04 2005-12-29 Huan-Chen Li Medical device for treating skin problems
US7537605B2 (en) * 1993-10-04 2009-05-26 Huan-Chen Li Medical device for treating skin itch and rash
US5863290A (en) * 1995-08-15 1999-01-26 Rita Medical Systems Multiple antenna ablation apparatus and method
US6090105A (en) 1995-08-15 2000-07-18 Rita Medical Systems, Inc. Multiple electrode ablation apparatus and method
US5810804A (en) * 1995-08-15 1998-09-22 Rita Medical Systems Multiple antenna ablation apparatus and method with cooling element
US5672173A (en) * 1995-08-15 1997-09-30 Rita Medical Systems, Inc. Multiple antenna ablation apparatus and method
US5728143A (en) * 1995-08-15 1998-03-17 Rita Medical Systems, Inc. Multiple antenna ablation apparatus and method
US5782827A (en) * 1995-08-15 1998-07-21 Rita Medical Systems, Inc. Multiple antenna ablation apparatus and method with multiple sensor feedback
US5913855A (en) 1995-08-15 1999-06-22 Rita Medical Systems, Inc. Multiple antenna ablation apparatus and method
US6071280A (en) 1993-11-08 2000-06-06 Rita Medical Systems, Inc. Multiple electrode ablation apparatus
US5951547A (en) 1995-08-15 1999-09-14 Rita Medical Systems, Inc. Multiple antenna ablation apparatus and method
US6689127B1 (en) 1995-08-15 2004-02-10 Rita Medical Systems Multiple antenna ablation apparatus and method with multiple sensor feedback
US5925042A (en) 1995-08-15 1999-07-20 Rita Medical Systems, Inc. Multiple antenna ablation apparatus and method
US5672174A (en) * 1995-08-15 1997-09-30 Rita Medical Systems, Inc. Multiple antenna ablation apparatus and method
US6059780A (en) 1995-08-15 2000-05-09 Rita Medical Systems, Inc. Multiple antenna ablation apparatus and method with cooling element
US5980517A (en) 1995-08-15 1999-11-09 Rita Medical Systems, Inc. Cell necrosis apparatus
US6080150A (en) 1995-08-15 2000-06-27 Rita Medical Systems, Inc. Cell necrosis apparatus
US5683384A (en) 1993-11-08 1997-11-04 Zomed Multiple antenna ablation apparatus
US5928229A (en) 1993-11-08 1999-07-27 Rita Medical Systems, Inc. Tumor ablation apparatus
US6132425A (en) 1995-08-15 2000-10-17 Gough; Edward J. Cell necrosis apparatus
US5735847A (en) * 1995-08-15 1998-04-07 Zomed International, Inc. Multiple antenna ablation apparatus and method with cooling element
US6099524A (en) * 1994-01-28 2000-08-08 Cardiac Pacemakers, Inc. Electrophysiological mapping and ablation catheter and method
SG52621A1 (en) * 1994-02-09 1998-09-28 Keravision Inc An electrosurgical procedure recurving the cornea
US5800379A (en) * 1996-02-23 1998-09-01 Sommus Medical Technologies, Inc. Method for ablating interior sections of the tongue
US5738114A (en) * 1996-02-23 1998-04-14 Somnus Medical Technologies, Inc. Method and apparatus for treatment of air way obstructions
US5820580A (en) * 1996-02-23 1998-10-13 Somnus Medical Technologies, Inc. Method for ablating interior sections of the tongue
US5879349A (en) * 1996-02-23 1999-03-09 Somnus Medical Technologies, Inc. Apparatus for treatment of air way obstructions
US5728094A (en) * 1996-02-23 1998-03-17 Somnus Medical Technologies, Inc. Method and apparatus for treatment of air way obstructions
US6126657A (en) * 1996-02-23 2000-10-03 Somnus Medical Technologies, Inc. Apparatus for treatment of air way obstructions
US6273886B1 (en) 1998-02-19 2001-08-14 Curon Medical, Inc. Integrated tissue heating and cooling apparatus
US5827277A (en) * 1994-06-24 1998-10-27 Somnus Medical Technologies, Inc. Minimally invasive apparatus for internal ablation of turbinates
US6440128B1 (en) 1998-01-14 2002-08-27 Curon Medical, Inc. Actively cooled electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions
JP3879055B2 (en) 1998-02-19 2007-02-07 キューロン メディカル,インコーポレイテッド Electrosurgical sphincter treatment instrument
US6355031B1 (en) 1998-02-19 2002-03-12 Curon Medical, Inc. Control systems for multiple electrode arrays to create lesions in tissue regions at or near a sphincter
US5823197A (en) * 1994-06-24 1998-10-20 Somnus Medical Technologies, Inc. Method for internal ablation of turbinates
US6358245B1 (en) 1998-02-19 2002-03-19 Curon Medical, Inc. Graphical user interface for association with an electrode structure deployed in contact with a tissue region
US6402744B2 (en) 1998-02-19 2002-06-11 Curon Medical, Inc. Systems and methods for forming composite lesions to treat dysfunction in sphincters and adjoining tissue regions
US6423058B1 (en) 1998-02-19 2002-07-23 Curon Medical, Inc. Assemblies to visualize and treat sphincters and adjoining tissue regions
US6258087B1 (en) 1998-02-19 2001-07-10 Curon Medical, Inc. Expandable electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions
US6056744A (en) 1994-06-24 2000-05-02 Conway Stuart Medical, Inc. Sphincter treatment apparatus
US6325798B1 (en) 1998-02-19 2001-12-04 Curon Medical, Inc. Vacuum-assisted systems and methods for treating sphincters and adjoining tissue regions
US6044846A (en) * 1994-06-24 2000-04-04 Edwards; Stuart D. Method to treat esophageal sphincters
US6405732B1 (en) 1994-06-24 2002-06-18 Curon Medical, Inc. Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors
US8906010B2 (en) 1998-02-19 2014-12-09 Mederi Therapeutics, Inc. Graphical user interface for association with an electrode structure deployed in contact with a tissue region
US6009877A (en) * 1994-06-24 2000-01-04 Edwards; Stuart D. Method for treating a sphincter
US7165551B2 (en) 1998-02-19 2007-01-23 Curon Medical, Inc. Apparatus to detect and treat aberrant myoelectric activity
US6464697B1 (en) 1998-02-19 2002-10-15 Curon Medical, Inc. Stomach and adjoining tissue regions in the esophagus
US20030135206A1 (en) 1998-02-27 2003-07-17 Curon Medical, Inc. Method for treating a sphincter
US5800429A (en) * 1994-06-24 1998-09-01 Somnus Medical Technologies, Inc. Noninvasive apparatus for ablating turbinates
US6092528A (en) * 1994-06-24 2000-07-25 Edwards; Stuart D. Method to treat esophageal sphincters
US6113591A (en) * 1994-06-27 2000-09-05 Ep Technologies, Inc. Systems and methods for sensing sub-surface temperatures in body tissue
US5853409A (en) * 1994-06-27 1998-12-29 E.P. Technologies, Inc. Systems and apparatus for sensing temperature in body tissue
US5735846A (en) * 1994-06-27 1998-04-07 Ep Technologies, Inc. Systems and methods for ablating body tissue using predicted maximum tissue temperature
US5810802A (en) * 1994-08-08 1998-09-22 E.P. Technologies, Inc. Systems and methods for controlling tissue ablation using multiple temperature sensing elements
US6245068B1 (en) 1994-08-08 2001-06-12 Scimed Life Systems, Inc. Resilient radiopaque electrophysiology electrodes and probes including the same
EP1224917B1 (en) * 1997-10-10 2004-12-01 Boston Scientific Limited Soft tissue coagulation probe
US6142994A (en) 1994-10-07 2000-11-07 Ep Technologies, Inc. Surgical method and apparatus for positioning a diagnostic a therapeutic element within the body
US6645200B1 (en) 1997-10-10 2003-11-11 Scimed Life Systems, Inc. Method and apparatus for positioning a diagnostic or therapeutic element within the body and tip electrode for use with same
US6468272B1 (en) 1997-10-10 2002-10-22 Scimed Life Systems, Inc. Surgical probe for supporting diagnostic and therapeutic elements in contact with tissue in or around body orifices
US6464699B1 (en) 1997-10-10 2002-10-15 Scimed Life Systems, Inc. Method and apparatus for positioning a diagnostic or therapeutic element on body tissue and mask element for use with same
WO1996034570A1 (en) * 1995-05-01 1996-11-07 Ep Technologies, Inc. Systems and methods for obtaining desired lesion characteristics while ablating body tissue
US6053912A (en) * 1995-05-01 2000-04-25 Ep Techonologies, Inc. Systems and methods for sensing sub-surface temperatures in body tissue during ablation with actively cooled electrodes
US5688267A (en) * 1995-05-01 1997-11-18 Ep Technologies, Inc. Systems and methods for sensing multiple temperature conditions during tissue ablation
US5735280A (en) * 1995-05-02 1998-04-07 Heart Rhythm Technologies, Inc. Ultrasound energy delivery system and method
US5606974A (en) * 1995-05-02 1997-03-04 Heart Rhythm Technologies, Inc. Catheter having ultrasonic device
US6293943B1 (en) 1995-06-07 2001-09-25 Ep Technologies, Inc. Tissue heating and ablation systems and methods which predict maximum tissue temperature
US6022346A (en) * 1995-06-07 2000-02-08 Ep Technologies, Inc. Tissue heating and ablation systems and methods using self-heated electrodes
US5697925A (en) * 1995-06-09 1997-12-16 Engineering & Research Associates, Inc. Apparatus and method for thermal ablation
US6322558B1 (en) 1995-06-09 2001-11-27 Engineering & Research Associates, Inc. Apparatus and method for predicting ablation depth
US6113592A (en) * 1995-06-09 2000-09-05 Engineering & Research Associates, Inc. Apparatus and method for controlling ablation depth
US6117131A (en) * 1995-06-09 2000-09-12 Engineering & Research Associates, Inc. Multi-electrode probe for thermal ablation
US5868737A (en) * 1995-06-09 1999-02-09 Engineering Research & Associates, Inc. Apparatus and method for determining ablation
AUPN487495A0 (en) * 1995-08-18 1995-09-14 Cardiac Crc Nominees Pty Limited A multipolar transmural probe
JP2904066B2 (en) * 1995-08-31 1999-06-14 松下電器産業株式会社 Temperature sensor and manufacturing method thereof
US6302875B1 (en) 1996-10-11 2001-10-16 Transvascular, Inc. Catheters and related devices for forming passageways between blood vessels or other anatomical structures
DE29519651U1 (en) * 1995-12-14 1996-02-01 Muntermann Axel Apparatus for linear endomyocardial catheter ablation tissue radiofrequency
US5755760A (en) * 1996-03-11 1998-05-26 Medtronic, Inc. Deflectable catheter
US8353908B2 (en) 1996-09-20 2013-01-15 Novasys Medical, Inc. Treatment of tissue in sphincters, sinuses, and orifices
US5921954A (en) * 1996-07-10 1999-07-13 Mohr, Jr.; Lawrence G. Treating aneurysms by applying hardening/softening agents to hardenable/softenable substances
US6126682A (en) 1996-08-13 2000-10-03 Oratec Interventions, Inc. Method for treating annular fissures in intervertebral discs
US6338726B1 (en) 1997-02-06 2002-01-15 Vidacare, Inc. Treating urinary and other body strictures
US6063078A (en) * 1997-03-12 2000-05-16 Medtronic, Inc. Method and apparatus for tissue ablation
US5971983A (en) 1997-05-09 1999-10-26 The Regents Of The University Of California Tissue ablation device and method of use
US5849028A (en) * 1997-05-16 1998-12-15 Irvine Biomedical, Inc. Catheter and method for radiofrequency ablation of cardiac tissue
US6500174B1 (en) 1997-07-08 2002-12-31 Atrionix, Inc. Circumferential ablation device assembly and methods of use and manufacture providing an ablative circumferential band along an expandable member
US6997925B2 (en) 1997-07-08 2006-02-14 Atrionx, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
US6607502B1 (en) 1998-11-25 2003-08-19 Atrionix, Inc. Apparatus and method incorporating an ultrasound transducer onto a delivery member
US6966908B2 (en) 1997-07-08 2005-11-22 Atrionix, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
US6652515B1 (en) 1997-07-08 2003-11-25 Atrionix, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
US6024740A (en) 1997-07-08 2000-02-15 The Regents Of The University Of California Circumferential ablation device assembly
US6869431B2 (en) 1997-07-08 2005-03-22 Atrionix, Inc. Medical device with sensor cooperating with expandable member
US6164283A (en) * 1997-07-08 2000-12-26 The Regents Of The University Of California Device and method for forming a circumferential conduction block in a pulmonary vein
US6514249B1 (en) 1997-07-08 2003-02-04 Atrionix, Inc. Positioning system and method for orienting an ablation element within a pulmonary vein ostium
US6012457A (en) 1997-07-08 2000-01-11 The Regents Of The University Of California Device and method for forming a circumferential conduction block in a pulmonary vein
US9023031B2 (en) 1997-08-13 2015-05-05 Verathon Inc. Noninvasive devices, methods, and systems for modifying tissues
US6293941B1 (en) 1997-10-06 2001-09-25 Somnus Medical Technologies, Inc. Method and apparatus for impedance measurement in a multi-channel electro-surgical generator
US6942661B2 (en) 2000-08-30 2005-09-13 Boston Scientific Scimed, Inc. Fluid cooled apparatus for supporting diagnostic and therapeutic elements in contact with tissue
US6152920A (en) * 1997-10-10 2000-11-28 Ep Technologies, Inc. Surgical method and apparatus for positioning a diagnostic or therapeutic element within the body
US5957862A (en) * 1997-12-01 1999-09-28 Lu; Cheng-Liang Acupuncture device system and methods thereof
US5935124A (en) * 1997-12-02 1999-08-10 Cordis Webster, Inc. Tip electrode with multiple temperature sensors
AU2114299A (en) 1998-01-14 1999-08-02 Conway-Stuart Medical, Inc. Electrosurgical device for sphincter treatment
CA2318315A1 (en) 1998-01-14 1999-07-22 Conway-Stuart Medical, Inc. Electrosurgical apparatus for treating gastroesophageal reflux disease (gerd) and method
AU2317899A (en) 1998-01-14 1999-08-02 Conway-Stuart Medical, Inc. Gerd treatment apparatus and method
EP1056404A1 (en) * 1998-02-19 2000-12-06 Curon Medical Inc. Apparatus to detect and electosurgically treat aberrant myoelectric activity
US6790207B2 (en) 1998-06-04 2004-09-14 Curon Medical, Inc. Systems and methods for applying a selected treatment agent into contact with tissue to treat disorders of the gastrointestinal tract
US6802841B2 (en) 1998-06-04 2004-10-12 Curon Medical, Inc. Systems and methods for applying a selected treatment agent into contact with tissue to treat sphincter dysfunction
JP2002504390A (en) 1998-02-27 2002-02-12 キューロン メディカル,インコーポレイテッド Apparatus for treating electrically surgically esophageal sphincter
AU753618B2 (en) 1998-03-06 2002-10-24 Curon Medical, Inc. Apparatus to electrosurgically treat esophageal sphincters
US5989248A (en) * 1998-04-07 1999-11-23 Tu; Hosheng Medical device and methods for treating tissues
US6131579A (en) 1998-04-21 2000-10-17 Somnus Medical Technologies, Inc. Wire based temperature sensing electrode
AU3672299A (en) 1998-04-30 1999-11-16 Stuart D Edwards Electrosurgical sphincter treatment apparatus
US6416505B1 (en) 1998-05-05 2002-07-09 Scimed Life Systems, Inc. Surgical method and apparatus for positioning a diagnostic or therapeutic element within the body and pressure application probe for use with same
US6120496A (en) * 1998-05-05 2000-09-19 Scimed Life Systems, Inc. Surgical method and apparatus for positioning a diagnostic or therapeutic element within the body and coupling device for use with same
US6045550A (en) * 1998-05-05 2000-04-04 Cardiac Peacemakers, Inc. Electrode having non-joined thermocouple for providing multiple temperature-sensitive junctions
US6267760B1 (en) 1998-05-05 2001-07-31 Scimed Life Systems, Inc. Surgical method and apparatus for positioning a diagnostic or therapeutic element within the body and forming an incision in tissue with minimal blood loss
US6042580A (en) 1998-05-05 2000-03-28 Cardiac Pacemakers, Inc. Electrode having composition-matched, common-lead thermocouple wire for providing multiple temperature-sensitive junctions
US6312425B1 (en) * 1998-05-05 2001-11-06 Cardiac Pacemakers, Inc. RF ablation catheter tip electrode with multiple thermal sensors
US6071281A (en) * 1998-05-05 2000-06-06 Ep Technologies, Inc. Surgical method and apparatus for positioning a diagnostic or therapeutic element within the body and remote power control unit for use with same
US6837885B2 (en) 1998-05-22 2005-01-04 Scimed Life Systems, Inc. Surgical probe for supporting inflatable therapeutic devices in contact with tissue in or around body orifices and within tumors
US6409722B1 (en) * 1998-07-07 2002-06-25 Medtronic, Inc. Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue
US6537272B2 (en) 1998-07-07 2003-03-25 Medtronic, Inc. Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue
US6123702A (en) 1998-09-10 2000-09-26 Scimed Life Systems, Inc. Systems and methods for controlling power in an electrosurgical probe
US6245065B1 (en) 1998-09-10 2001-06-12 Scimed Life Systems, Inc. Systems and methods for controlling power in an electrosurgical probe
US6183468B1 (en) 1998-09-10 2001-02-06 Scimed Life Systems, Inc. Systems and methods for controlling power in an electrosurgical probe
US6123675A (en) * 1998-10-06 2000-09-26 Trex Medical Corporation Temperature gradient sensing probe for monitoring hyperthermic medical treatments
US7901400B2 (en) 1998-10-23 2011-03-08 Covidien Ag Method and system for controlling output of RF medical generator
US7137980B2 (en) 1998-10-23 2006-11-21 Sherwood Services Ag Method and system for controlling output of RF medical generator
US6451015B1 (en) * 1998-11-18 2002-09-17 Sherwood Services Ag Method and system for menu-driven two-dimensional display lesion generator
DE59915265D1 (en) * 1998-12-18 2011-06-16 Celon Ag Medical Instruments Electrode assembly for a surgical instrument for electrothermal coagulation in tissue
US6217528B1 (en) 1999-02-11 2001-04-17 Scimed Life Systems, Inc. Loop structure having improved tissue contact capability
US6450953B1 (en) 1999-04-15 2002-09-17 Nexan Limited Portable signal transfer unit
US6494829B1 (en) 1999-04-15 2002-12-17 Nexan Limited Physiological sensor array
US6454708B1 (en) 1999-04-15 2002-09-24 Nexan Limited Portable remote patient telemonitoring system using a memory card or smart card
US6385473B1 (en) 1999-04-15 2002-05-07 Nexan Limited Physiological sensor device
US6416471B1 (en) 1999-04-15 2002-07-09 Nexan Limited Portable remote patient telemonitoring system
US6939346B2 (en) 1999-04-21 2005-09-06 Oratec Interventions, Inc. Method and apparatus for controlling a temperature-controlled probe
AU4696100A (en) 1999-05-04 2000-11-17 Curon Medical, Inc. Electrodes for creating lesions in tissue regions at or near a sphincter
US6595989B1 (en) 1999-05-11 2003-07-22 Atrionix, Inc. Balloon anchor wire
US6758830B1 (en) 1999-05-11 2004-07-06 Atrionix, Inc. Catheter positioning system
US6696844B2 (en) 1999-06-04 2004-02-24 Engineering & Research Associates, Inc. Apparatus and method for real time determination of materials' electrical properties
DE20012237U1 (en) * 1999-07-26 2000-10-12 Storz Karl Gmbh & Co Kg Medical instrument with a contactlessly readable information carrier
AU7480200A (en) 1999-09-08 2001-04-10 Curon Medical, Inc. System for controlling a family of treatment devices
US6733495B1 (en) 1999-09-08 2004-05-11 Curon Medical, Inc. Systems and methods for monitoring and controlling use of medical devices
US8845632B2 (en) 2000-05-18 2014-09-30 Mederi Therapeutics, Inc. Graphical user interface for monitoring and controlling use of medical devices
EP1218801A4 (en) 1999-09-08 2009-07-01 Mederi Therapeutics Inc Systems and methods for monitoring and controlling use of medical devices
US7364577B2 (en) 2002-02-11 2008-04-29 Sherwood Services Ag Vessel sealing system
US6402741B1 (en) * 1999-10-08 2002-06-11 Sherwood Services Ag Current and status monitor
US20060095032A1 (en) 1999-11-16 2006-05-04 Jerome Jackson Methods and systems for determining physiologic characteristics for treatment of the esophagus
AU780278B2 (en) 1999-11-16 2005-03-10 Covidien Lp System and method of treating abnormal tissue in the human esophagus
US20040215235A1 (en) 1999-11-16 2004-10-28 Barrx, Inc. Methods and systems for determining physiologic characteristics for treatment of the esophagus
EP1233716B1 (en) 1999-11-22 2014-07-30 Boston Scientific Limited Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US6645199B1 (en) 1999-11-22 2003-11-11 Scimed Life Systems, Inc. Loop structures for supporting diagnostic and therapeutic elements contact with body tissue and expandable push devices for use with same
US6635057B2 (en) * 1999-12-02 2003-10-21 Olympus Optical Co. Ltd. Electric operation apparatus
US6547776B1 (en) 2000-01-03 2003-04-15 Curon Medical, Inc. Systems and methods for treating tissue in the crura
US6383144B1 (en) * 2000-01-18 2002-05-07 Edwards Lifesciences Corporation Devices and methods for measuring temperature of a patient
DE10008918A1 (en) * 2000-02-25 2001-08-30 Biotronik Mess & Therapieg Ablation catheter to generate linear lesions in heart muscle; has catheter body with linear, cylindrical ablation electrode and at least one insulated sensing electrode
US8048070B2 (en) 2000-03-06 2011-11-01 Salient Surgical Technologies, Inc. Fluid-assisted medical devices, systems and methods
US7811282B2 (en) 2000-03-06 2010-10-12 Salient Surgical Technologies, Inc. Fluid-assisted electrosurgical devices, electrosurgical unit with pump and methods of use thereof
AU3998701A (en) 2000-03-06 2001-09-17 Tissuelink Medical Inc Fluid delivery system and controller for electrosurgical devices
US6536949B1 (en) * 2000-03-07 2003-03-25 Richard R. Heuser Catheter for thermal evaluation of arteriosclerotic plaque
AU5161001A (en) 2000-04-13 2001-11-07 Ocean Spray Cranberries Inc Novel compositions derived from cranberry and grapefruit and therapeutic uses therefor
WO2001082811A1 (en) 2000-04-27 2001-11-08 Medtronic, Inc. System and method for assessing transmurality of ablation lesions
US6599288B2 (en) 2000-05-16 2003-07-29 Atrionix, Inc. Apparatus and method incorporating an ultrasound transducer onto a delivery member
AT290827T (en) 2000-06-13 2005-04-15 Atrionix Inc A surgical ablation probe for forming a circumferential lesion
US6511478B1 (en) * 2000-06-30 2003-01-28 Scimed Life Systems, Inc. Medical probe with reduced number of temperature sensor wires
US7789876B2 (en) 2000-08-14 2010-09-07 Tyco Healthcare Group, Lp Method and apparatus for positioning a catheter relative to an anatomical junction
US6773405B2 (en) * 2000-09-15 2004-08-10 Jacob Fraden Ear temperature monitor and method of temperature measurement
US6558385B1 (en) 2000-09-22 2003-05-06 Tissuelink Medical, Inc. Fluid-assisted medical device
US7306591B2 (en) 2000-10-02 2007-12-11 Novasys Medical, Inc. Apparatus and methods for treating female urinary incontinence
US6916306B1 (en) 2000-11-10 2005-07-12 Boston Scientific Scimed, Inc. Steerable loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US20040092806A1 (en) * 2001-12-11 2004-05-13 Sagon Stephen W Microelectrode catheter for mapping and ablation
US7047068B2 (en) * 2000-12-11 2006-05-16 C.R. Bard, Inc. Microelectrode catheter for mapping and ablation
WO2002047569A1 (en) 2000-12-11 2002-06-20 C.R. Bard, Inc. Microelectrode catheter for mapping and ablation
US6743237B2 (en) * 2001-01-17 2004-06-01 Innon Holdings, Llc Endoscopic stone extraction device with improved basket
US6827714B2 (en) 2001-03-07 2004-12-07 Scimed Life Systems, Inc. Internal indifferent electrode device for use with lesion creation apparatus and method of forming lesions using the same
US6689131B2 (en) 2001-03-08 2004-02-10 Tissuelink Medical, Inc. Electrosurgical device having a tissue reduction sensor
US7959626B2 (en) 2001-04-26 2011-06-14 Medtronic, Inc. Transmural ablation systems and methods
US7250048B2 (en) * 2001-04-26 2007-07-31 Medtronic, Inc. Ablation system and method of use
US6989010B2 (en) 2001-04-26 2006-01-24 Medtronic, Inc. Ablation system and method of use
US6648883B2 (en) * 2001-04-26 2003-11-18 Medtronic, Inc. Ablation system and method of use
US6569114B2 (en) 2001-08-31 2003-05-27 Biosense Webster, Inc. Steerable catheter with struts
US6939350B2 (en) 2001-10-22 2005-09-06 Boston Scientific Scimed, Inc. Apparatus for supporting diagnostic and therapeutic elements in contact with tissue including electrode cooling device
AU2002357166A1 (en) 2001-12-12 2003-06-23 Tissuelink Medical, Inc. Fluid-assisted medical devices, systems and methods
US6932816B2 (en) 2002-02-19 2005-08-23 Boston Scientific Scimed, Inc. Apparatus for converting a clamp into an electrophysiology device
US20030158548A1 (en) 2002-02-19 2003-08-21 Phan Huy D. Surgical system including clamp and apparatus for securing an energy transmission device to the clamp and method of converting a clamp into an electrophysiology device
US7753908B2 (en) 2002-02-19 2010-07-13 Endoscopic Technologies, Inc. (Estech) Apparatus for securing an electrophysiology probe to a clamp
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US8774922B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US9308044B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US20060206150A1 (en) 2002-04-08 2006-09-14 Ardian, Inc. Methods and apparatus for treating acute myocardial infarction
US9308043B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US20140018880A1 (en) 2002-04-08 2014-01-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US20110207758A1 (en) 2003-04-08 2011-08-25 Medtronic Vascular, Inc. Methods for Therapeutic Renal Denervation
EP2842604A1 (en) 2006-06-28 2015-03-04 Medtronic Ardian Luxembourg S.à.r.l. Systems for thermally-induced renal neuromodulation
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US7258688B1 (en) * 2002-04-16 2007-08-21 Baylis Medical Company Inc. Computerized electrical signal generator
AU2003265331B2 (en) 2002-05-06 2008-03-20 Covidien Ag Blood detector for controlling anesu and method therefor
US6953461B2 (en) * 2002-05-16 2005-10-11 Tissuelink Medical, Inc. Fluid-assisted medical devices, systems and methods
CN1329008C (en) 2002-06-19 2007-08-01 帕洛玛医疗技术公司 Method and apparatus for treatment of cutaneous and subcutaneous conditions
US20040082859A1 (en) 2002-07-01 2004-04-29 Alan Schaer Method and apparatus employing ultrasound energy to treat body sphincters
US20060167445A1 (en) * 2002-08-27 2006-07-27 Gal Shafirstein Selective conductive interstitial thermal therapy device
US6780177B2 (en) 2002-08-27 2004-08-24 Board Of Trustees Of The University Of Arkansas Conductive interstitial thermal therapy device
US7674258B2 (en) 2002-09-24 2010-03-09 Endoscopic Technologies, Inc. (ESTECH, Inc.) Electrophysiology electrode having multiple power connections and electrophysiology devices including the same
US7300459B2 (en) 2002-10-17 2007-11-27 Heuser Richard R Stent with covering and differential dilation
JP2006504472A (en) 2002-10-29 2006-02-09 ティシューリンク・メディカル・インコーポレーテッドTissuelink Medical,Inc. Fluid-assisted electrosurgical scissors and method
US7044948B2 (en) 2002-12-10 2006-05-16 Sherwood Services Ag Circuit for controlling arc energy from an electrosurgical generator
GB0230055D0 (en) 2002-12-23 2003-01-29 Gyrus Medical Ltd Electrosurgical method and apparatus
US7166088B2 (en) 2003-01-27 2007-01-23 Heuser Richard R Catheter introducer system
US7357800B2 (en) * 2003-02-14 2008-04-15 Boston Scientific Scimed, Inc. Power supply and control apparatus and electrophysiology systems including the same
EP1617776B1 (en) 2003-05-01 2015-09-02 Covidien AG System for programing and controlling an electrosurgical generator system
US9060770B2 (en) 2003-05-20 2015-06-23 Ethicon Endo-Surgery, Inc. Robotically-driven surgical instrument with E-beam driver
US20040238987A1 (en) * 2003-05-30 2004-12-02 Jensen Joseph C. Temperature control for molds
US7137979B2 (en) * 2003-05-31 2006-11-21 Tyrell, Inc. Methods and devices for the treatment of skin lesions
US7785266B2 (en) 2003-08-19 2010-08-31 Advanced Monitors Corporation Medical thermometer for determining body core temperature
US7938783B2 (en) 2003-08-19 2011-05-10 Advanced Monitors Corporation Medical body core thermometer
US7402141B2 (en) 2003-08-27 2008-07-22 Heuser Richard R Catheter guidewire system using concentric wires
US8545418B2 (en) 2004-08-25 2013-10-01 Richard R. Heuser Systems and methods for ablation of occlusions within blood vessels
DE10342709A1 (en) * 2003-09-11 2005-04-21 Biotronik Gmbh & Co Kg catheter
US9713730B2 (en) 2004-09-10 2017-07-25 Boston Scientific Scimed, Inc. Apparatus and method for treatment of in-stent restenosis
DE202004021952U1 (en) 2003-09-12 2013-06-19 Vessix Vascular, Inc. Selectable eccentric remodeling and / or ablation of atherosclerotic material
US7435248B2 (en) * 2003-09-26 2008-10-14 Boston Scientific Scimed, Inc. Medical probes for creating and diagnosing circumferential lesions within or around the ostium of a vessel
ES2372045T3 (en) 2003-10-23 2012-01-13 Covidien Ag Redundant temperature monitoring in electrochurgical systems to attenate safety.
US8104956B2 (en) 2003-10-23 2012-01-31 Covidien Ag Thermocouple measurement circuit
US7396336B2 (en) 2003-10-30 2008-07-08 Sherwood Services Ag Switched resonant ultrasonic power amplifier system
US7131860B2 (en) 2003-11-20 2006-11-07 Sherwood Services Ag Connector systems for electrosurgical generator
US7150745B2 (en) 2004-01-09 2006-12-19 Barrx Medical, Inc. Devices and methods for treatment of luminal tissue
JP4151910B2 (en) * 2004-01-27 2008-09-17 日本ライフライン株式会社 Ablation catheter
US7727232B1 (en) 2004-02-04 2010-06-01 Salient Surgical Technologies, Inc. Fluid-assisted medical devices and methods
US7766905B2 (en) 2004-02-12 2010-08-03 Covidien Ag Method and system for continuity testing of medical electrodes
US7780662B2 (en) 2004-03-02 2010-08-24 Covidien Ag Vessel sealing system using capacitive RF dielectric heating
US7128467B2 (en) * 2004-03-18 2006-10-31 General Electric Company Thermistor probe assembly and method for positioning and moisture proofing thermistor probe assembly
US7377918B2 (en) * 2004-04-28 2008-05-27 Gyrus Medical Limited Electrosurgical method and apparatus
US8333764B2 (en) 2004-05-12 2012-12-18 Medtronic, Inc. Device and method for determining tissue thickness and creating cardiac ablation lesions
US20050283148A1 (en) * 2004-06-17 2005-12-22 Janssen William M Ablation apparatus and system to limit nerve conduction
US8215531B2 (en) 2004-07-28 2012-07-10 Ethicon Endo-Surgery, Inc. Surgical stapling instrument having a medical substance dispenser
US8905977B2 (en) 2004-07-28 2014-12-09 Ethicon Endo-Surgery, Inc. Surgical stapling instrument having an electroactive polymer actuated medical substance dispenser
US20070016272A1 (en) 2004-09-27 2007-01-18 Thompson Russell B Systems and methods for treating a hollow anatomical structure
US20070055326A1 (en) 2005-07-21 2007-03-08 Farley Brian E Method of treating a hollow anatomical structure with a thermal catheter
US7628786B2 (en) 2004-10-13 2009-12-08 Covidien Ag Universal foot switch contact port
US8409191B2 (en) * 2004-11-04 2013-04-02 Boston Scientific Scimed, Inc. Preshaped ablation catheter for ablating pulmonary vein ostia within the heart
CA2588120C (en) * 2004-11-15 2017-05-30 Biosense Webster Inc. Catheter with multiple microfabricated temperature sensors
US7842076B2 (en) 2004-12-20 2010-11-30 Tyco Healthcare Group, Lp Systems and methods for treating a hollow anatomical structure
US7776033B2 (en) * 2005-01-08 2010-08-17 Boston Scientific Scimed, Inc. Wettable structures including conductive fibers and apparatus including the same
US7862561B2 (en) * 2005-01-08 2011-01-04 Boston Scientific Scimed, Inc. Clamp based lesion formation apparatus with variable spacing structures
US7727231B2 (en) 2005-01-08 2010-06-01 Boston Scientific Scimed, Inc. Apparatus and methods for forming lesions in tissue and applying stimulation energy to tissue in which lesions are formed
US7643883B2 (en) * 2005-01-28 2010-01-05 Syneron Medical Ltd. Device and method for treating skin
US7785324B2 (en) 2005-02-25 2010-08-31 Endoscopic Technologies, Inc. (Estech) Clamp based lesion formation apparatus and methods configured to protect non-target tissue
US9474564B2 (en) 2005-03-31 2016-10-25 Covidien Ag Method and system for compensating for external impedance of an energy carrying component when controlling an electrosurgical generator
US7856985B2 (en) 2005-04-22 2010-12-28 Cynosure, Inc. Method of treatment body tissue using a non-uniform laser beam
US20060247522A1 (en) * 2005-04-28 2006-11-02 Boston Scientific Scimed, Inc. Magnetic navigation systems with dynamic mechanically manipulatable catheters
EP1876985B1 (en) 2005-05-05 2016-08-31 Boston Scientific Scimed, Inc. System for graphically reconstructing pulmonary vein ostia with preshaped localization catheter
US8128621B2 (en) 2005-05-16 2012-03-06 St. Jude Medical, Atrial Fibrillation Division, Inc. Irrigated ablation electrode assembly and method for control of temperature
US20080091193A1 (en) * 2005-05-16 2008-04-17 James Kauphusman Irrigated ablation catheter having magnetic tip for magnetic field control and guidance
MX2007014439A (en) * 2005-05-18 2008-02-11 Tyrell Inc Treatment device and method for treating skin lesions through application of heat.
US8376990B2 (en) * 2005-05-19 2013-02-19 Biosense Webster, Inc. Steerable catheter with distal tip orientation sheaths
US8932208B2 (en) 2005-05-26 2015-01-13 Maquet Cardiovascular Llc Apparatus and methods for performing minimally-invasive surgical procedures
US7655003B2 (en) 2005-06-22 2010-02-02 Smith & Nephew, Inc. Electrosurgical power control
EP1906855A2 (en) * 2005-07-05 2008-04-09 Edwin Langberg Electrodes using two-phase heat transfer and multi-variate algorithms for improved temperature monitoring and control
US20070021803A1 (en) 2005-07-22 2007-01-25 The Foundry Inc. Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction
EP2289449B1 (en) * 2005-08-02 2013-12-25 Neurotherm, Inc. Apparatus for diagnosing and treating neural dysfunction
EP1754512A3 (en) * 2005-08-18 2008-03-05 Neurotherm, Inc. Method and apparatus for diagnosing and treating neural dysfunction
US8800838B2 (en) 2005-08-31 2014-08-12 Ethicon Endo-Surgery, Inc. Robotically-controlled cable-based surgical end effectors
US9237891B2 (en) 2005-08-31 2016-01-19 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical stapling devices that produce formed staples having different lengths
US7669746B2 (en) 2005-08-31 2010-03-02 Ethicon Endo-Surgery, Inc. Staple cartridges for forming staples having differing formed staple heights
US7934630B2 (en) 2005-08-31 2011-05-03 Ethicon Endo-Surgery, Inc. Staple cartridges for forming staples having differing formed staple heights
US20070194079A1 (en) 2005-08-31 2007-08-23 Hueil Joseph C Surgical stapling device with staple drivers of different height
US10159482B2 (en) 2005-08-31 2018-12-25 Ethicon Llc Fastener cartridge assembly comprising a fixed anvil and different staple heights
US8734438B2 (en) 2005-10-21 2014-05-27 Covidien Ag Circuit and method for reducing stored energy in an electrosurgical generator
US7673783B2 (en) 2005-11-04 2010-03-09 Ethicon Endo-Surgery, Inc. Surgical stapling instruments structured for delivery of medical agents
US7673780B2 (en) 2005-11-09 2010-03-09 Ethicon Endo-Surgery, Inc. Articulation joint with improved moment arm extension for articulating an end effector of a surgical instrument
US20070106317A1 (en) 2005-11-09 2007-05-10 Shelton Frederick E Iv Hydraulically and electrically actuated articulation joints for surgical instruments
US7799039B2 (en) 2005-11-09 2010-09-21 Ethicon Endo-Surgery, Inc. Surgical instrument having a hydraulically actuated end effector
US8702694B2 (en) 2005-11-23 2014-04-22 Covidien Lp Auto-aligning ablating device and method of use
US7959627B2 (en) 2005-11-23 2011-06-14 Barrx Medical, Inc. Precision ablating device
US7997278B2 (en) 2005-11-23 2011-08-16 Barrx Medical, Inc. Precision ablating method
US7947039B2 (en) 2005-12-12 2011-05-24 Covidien Ag Laparoscopic apparatus for performing electrosurgical procedures
US7620451B2 (en) 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US7670334B2 (en) 2006-01-10 2010-03-02 Ethicon Endo-Surgery, Inc. Surgical instrument having an articulating end effector
US8216223B2 (en) 2006-01-24 2012-07-10 Covidien Ag System and method for tissue sealing
CA2574935A1 (en) 2006-01-24 2007-07-24 Sherwood Services Ag A method and system for controlling an output of a radio-frequency medical generator having an impedance based control algorithm
US7513896B2 (en) 2006-01-24 2009-04-07 Covidien Ag Dual synchro-resonant electrosurgical apparatus with bi-directional magnetic coupling
JP5160793B2 (en) 2006-01-24 2013-03-13 コヴィディエン・アクチェンゲゼルシャフト Systems and methods for tissue sealing
US8147485B2 (en) 2006-01-24 2012-04-03 Covidien Ag System and method for tissue sealing
CA2574934C (en) 2006-01-24 2015-12-29 Sherwood Services Ag System and method for closed loop monitoring of monopolar electrosurgical apparatus
US9186200B2 (en) 2006-01-24 2015-11-17 Covidien Ag System and method for tissue sealing
US8685016B2 (en) 2006-01-24 2014-04-01 Covidien Ag System and method for tissue sealing
US8062321B2 (en) 2006-01-25 2011-11-22 Pq Bypass, Inc. Catheter system for connecting adjacent blood vessels
US7374567B2 (en) 2006-01-25 2008-05-20 Heuser Richard R Catheter system for connecting adjacent blood vessels
US8161977B2 (en) 2006-01-31 2012-04-24 Ethicon Endo-Surgery, Inc. Accessing data stored in a memory of a surgical instrument
US20120292367A1 (en) 2006-01-31 2012-11-22 Ethicon Endo-Surgery, Inc. Robotically-controlled end effector
US8763879B2 (en) 2006-01-31 2014-07-01 Ethicon Endo-Surgery, Inc. Accessing data stored in a memory of surgical instrument
US20110295295A1 (en) 2006-01-31 2011-12-01 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical instrument having recording capabilities
US8820603B2 (en) 2006-01-31 2014-09-02 Ethicon Endo-Surgery, Inc. Accessing data stored in a memory of a surgical instrument
US8708213B2 (en) 2006-01-31 2014-04-29 Ethicon Endo-Surgery, Inc. Surgical instrument having a feedback system
US7766210B2 (en) 2006-01-31 2010-08-03 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting and fastening instrument with user feedback system
US9861359B2 (en) 2006-01-31 2018-01-09 Ethicon Llc Powered surgical instruments with firing system lockout arrangements
US7845537B2 (en) 2006-01-31 2010-12-07 Ethicon Endo-Surgery, Inc. Surgical instrument having recording capabilities
US7753904B2 (en) 2006-01-31 2010-07-13 Ethicon Endo-Surgery, Inc. Endoscopic surgical instrument with a handle that can articulate with respect to the shaft
US7568603B2 (en) 2006-01-31 2009-08-04 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting and fastening instrument with articulatable end effector
US8186555B2 (en) 2006-01-31 2012-05-29 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting and fastening instrument with mechanical closure system
US7770775B2 (en) 2006-01-31 2010-08-10 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting and fastening instrument with adaptive user feedback
US7644848B2 (en) 2006-01-31 2010-01-12 Ethicon Endo-Surgery, Inc. Electronic lockouts and surgical instrument including same
US7651493B2 (en) 2006-03-03 2010-01-26 Covidien Ag System and method for controlling electrosurgical snares
US7648499B2 (en) 2006-03-21 2010-01-19 Covidien Ag System and method for generating radio frequency energy
US8992422B2 (en) 2006-03-23 2015-03-31 Ethicon Endo-Surgery, Inc. Robotically-controlled endoscopic accessory channel
US20070225562A1 (en) 2006-03-23 2007-09-27 Ethicon Endo-Surgery, Inc. Articulating endoscopic accessory channel
US7651492B2 (en) 2006-04-24 2010-01-26 Covidien Ag Arc based adaptive control system for an electrosurgical unit
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
US8753334B2 (en) 2006-05-10 2014-06-17 Covidien Ag System and method for reducing leakage current in an electrosurgical generator
US7857810B2 (en) * 2006-05-16 2010-12-28 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation electrode assembly and methods for improved control of temperature and minimization of coagulation and tissue damage
US8322455B2 (en) 2006-06-27 2012-12-04 Ethicon Endo-Surgery, Inc. Manually driven surgical cutting and fastening instrument
US7586957B2 (en) 2006-08-02 2009-09-08 Cynosure, Inc Picosecond laser apparatus and methods for its operation and use
US7740159B2 (en) 2006-08-02 2010-06-22 Ethicon Endo-Surgery, Inc. Pneumatically powered surgical cutting and fastening instrument with a variable control of the actuating rate of firing with mechanical power assist
US8034049B2 (en) 2006-08-08 2011-10-11 Covidien Ag System and method for measuring initial tissue impedance
US7731717B2 (en) 2006-08-08 2010-06-08 Covidien Ag System and method for controlling RF output during tissue sealing
US7794457B2 (en) 2006-09-28 2010-09-14 Covidien Ag Transformer for RF voltage sensing
US8720766B2 (en) 2006-09-29 2014-05-13 Ethicon Endo-Surgery, Inc. Surgical stapling instruments and staples
US10130359B2 (en) 2006-09-29 2018-11-20 Ethicon Llc Method for forming a staple
WO2008045877A2 (en) 2006-10-10 2008-04-17 St. Jude Medical, Atrial Fibrillation Division, Inc. Electrode tip and ablation system
JP5479901B2 (en) 2006-10-18 2014-04-23 べシックス・バスキュラー・インコーポレイテッド Induction of desired temperature effects on body tissue
EP2455036B1 (en) 2006-10-18 2015-07-15 Vessix Vascular, Inc. Tuned RF energy and electrical tissue characterization for selective treatment of target tissues
EP2076194B1 (en) 2006-10-18 2013-04-24 Vessix Vascular, Inc. System for inducing desirable temperature effects on body tissue
US20080154257A1 (en) * 2006-12-22 2008-06-26 Shiva Sharareh Real-time optoacoustic monitoring with electophysiologic catheters
US8460285B2 (en) * 2006-12-29 2013-06-11 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation catheter electrode having multiple thermal sensors and method of use
US8684253B2 (en) 2007-01-10 2014-04-01 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between a control unit of a robotic system and remote sensor
US8652120B2 (en) 2007-01-10 2014-02-18 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between control unit and sensor transponders
US7954682B2 (en) 2007-01-10 2011-06-07 Ethicon Endo-Surgery, Inc. Surgical instrument with elements to communicate between control unit and end effector
US8459520B2 (en) 2007-01-10 2013-06-11 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between control unit and remote sensor
US7721931B2 (en) 2007-01-10 2010-05-25 Ethicon Endo-Surgery, Inc. Prevention of cartridge reuse in a surgical instrument
US7900805B2 (en) 2007-01-10 2011-03-08 Ethicon Endo-Surgery, Inc. Surgical instrument with enhanced battery performance
US7738971B2 (en) 2007-01-10 2010-06-15 Ethicon Endo-Surgery, Inc. Post-sterilization programming of surgical instruments
US7721936B2 (en) 2007-01-10 2010-05-25 Ethicon Endo-Surgery, Inc. Interlock and surgical instrument including same
US8701958B2 (en) 2007-01-11 2014-04-22 Ethicon Endo-Surgery, Inc. Curved end effector for a surgical stapling device
US8211099B2 (en) 2007-01-31 2012-07-03 Tyco Healthcare Group Lp Thermal feedback systems and methods of using the same
US7431188B1 (en) 2007-03-15 2008-10-07 Tyco Healthcare Group Lp Surgical stapling apparatus with powered articulation
US20080234813A1 (en) * 2007-03-20 2008-09-25 Heuser Richard R Percutaneous Interventional Cardiology System for Treating Valvular Disease
US8893946B2 (en) 2007-03-28 2014-11-25 Ethicon Endo-Surgery, Inc. Laparoscopic tissue thickness and clamp load measuring devices
US8056787B2 (en) 2007-03-28 2011-11-15 Ethicon Endo-Surgery, Inc. Surgical stapling and cutting instrument with travel-indicating retraction member
US8641711B2 (en) 2007-05-04 2014-02-04 Covidien Lp Method and apparatus for gastrointestinal tract ablation for treatment of obesity
US8777941B2 (en) 2007-05-10 2014-07-15 Covidien Lp Adjustable impedance electrosurgical electrodes
US7810693B2 (en) 2007-05-30 2010-10-12 Ethicon Endo-Surgery, Inc. Surgical stapling and cutting instrument with articulatable end effector
US7798386B2 (en) 2007-05-30 2010-09-21 Ethicon Endo-Surgery, Inc. Surgical instrument articulation joint cover
US8157145B2 (en) 2007-05-31 2012-04-17 Ethicon Endo-Surgery, Inc. Pneumatically powered surgical cutting and fastening instrument with electrical feedback
US7905380B2 (en) 2007-06-04 2011-03-15 Ethicon Endo-Surgery, Inc. Surgical instrument having a multiple rate directional switching mechanism
US8534528B2 (en) 2007-06-04 2013-09-17 Ethicon Endo-Surgery, Inc. Surgical instrument having a multiple rate directional switching mechanism
US7819299B2 (en) 2007-06-04 2010-10-26 Ethicon Endo-Surgery, Inc. Surgical instrument having a common trigger for actuating an end effector closing system and a staple firing system
US7832408B2 (en) 2007-06-04 2010-11-16 Ethicon Endo-Surgery, Inc. Surgical instrument having a directional switching mechanism
US8931682B2 (en) 2007-06-04 2015-01-13 Ethicon Endo-Surgery, Inc. Robotically-controlled shaft based rotary drive systems for surgical instruments
WO2008154006A1 (en) 2007-06-08 2008-12-18 Cynosure, Inc. Coaxial suction system for laser lipolysis
US20080308602A1 (en) 2007-06-18 2008-12-18 Timm Richard W Surgical stapling and cutting instruments
US7658311B2 (en) 2007-06-22 2010-02-09 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with a geared return mechanism
US8308040B2 (en) 2007-06-22 2012-11-13 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with an articulatable end effector
US7753245B2 (en) 2007-06-22 2010-07-13 Ethicon Endo-Surgery, Inc. Surgical stapling instruments
US8784338B2 (en) 2007-06-22 2014-07-22 Covidien Lp Electrical means to normalize ablational energy transmission to a luminal tissue surface of varying size
US8439908B2 (en) 2007-07-06 2013-05-14 Covidien Lp Ablation in the gastrointestinal tract to achieve hemostasis and eradicate lesions with a propensity for bleeding
WO2009009443A1 (en) 2007-07-06 2009-01-15 Barrx Medical, Inc. Method and apparatus for gastrointestinal tract ablation to achieve loss of persistent and/or recurrent excess body weight following a weight-loss operation
US7834484B2 (en) 2007-07-16 2010-11-16 Tyco Healthcare Group Lp Connection cable and method for activating a voltage-controlled generator
US8646460B2 (en) 2007-07-30 2014-02-11 Covidien Lp Cleaning device and methods
US8273012B2 (en) 2007-07-30 2012-09-25 Tyco Healthcare Group, Lp Cleaning device and methods
WO2009029523A1 (en) * 2007-08-24 2009-03-05 Boston Scientific Scimed, Inc. Magnetically steerable catheter assembly
US8216220B2 (en) 2007-09-07 2012-07-10 Tyco Healthcare Group Lp System and method for transmission of combined data stream
US8512332B2 (en) 2007-09-21 2013-08-20 Covidien Lp Real-time arc control in electrosurgical generators
JP2010540160A (en) 2007-10-05 2010-12-24 マッケ カーディオバスキュラー,エルエルシー Apparatus and method for minimally invasive surgical procedures
US8535306B2 (en) 2007-11-05 2013-09-17 Angiodynamics, Inc. Ablation devices and methods of using the same
US8052684B2 (en) * 2007-11-30 2011-11-08 St. Jude Medical, Atrial Fibrillation Division, Inc. Irrigated ablation catheter having parallel external flow and proximally tapered electrode
US8353907B2 (en) 2007-12-21 2013-01-15 Atricure, Inc. Ablation device with internally cooled electrodes
US8998892B2 (en) 2007-12-21 2015-04-07 Atricure, Inc. Ablation device with cooled electrodes and methods of use
US8147443B2 (en) * 2007-12-28 2012-04-03 Boston Scientific Scimed, Inc. Indirect fluid flow measurement
US8453908B2 (en) 2008-02-13 2013-06-04 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with improved firing trigger arrangement
US8561870B2 (en) 2008-02-13 2013-10-22 Ethicon Endo-Surgery, Inc. Surgical stapling instrument
US7766209B2 (en) 2008-02-13 2010-08-03 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with improved firing trigger arrangement
US7793812B2 (en) 2008-02-14 2010-09-14 Ethicon Endo-Surgery, Inc. Disposable motor-driven loading unit for use with a surgical cutting and stapling apparatus
US9179912B2 (en) 2008-02-14 2015-11-10 Ethicon Endo-Surgery, Inc. Robotically-controlled motorized surgical cutting and fastening instrument
US7861906B2 (en) 2008-02-14 2011-01-04 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with articulatable components
RU2493788C2 (en) 2008-02-14 2013-09-27 Этикон Эндо-Серджери, Инк. Surgical cutting and fixing instrument, which has radio-frequency electrodes
US8752749B2 (en) 2008-02-14 2014-06-17 Ethicon Endo-Surgery, Inc. Robotically-controlled disposable motor-driven loading unit
US7819296B2 (en) 2008-02-14 2010-10-26 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with retractable firing systems
US8459525B2 (en) 2008-02-14 2013-06-11 Ethicon Endo-Sugery, Inc. Motorized surgical cutting and fastening instrument having a magnetic drive train torque limiting device
US7819297B2 (en) 2008-02-14 2010-10-26 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with reprocessible handle assembly
US8622274B2 (en) 2008-02-14 2014-01-07 Ethicon Endo-Surgery, Inc. Motorized cutting and fastening instrument having control circuit for optimizing battery usage
US8636736B2 (en) 2008-02-14 2014-01-28 Ethicon Endo-Surgery, Inc. Motorized surgical cutting and fastening instrument
US8584919B2 (en) 2008-02-14 2013-11-19 Ethicon Endo-Sugery, Inc. Surgical stapling apparatus with load-sensitive firing mechanism
US8758391B2 (en) 2008-02-14 2014-06-24 Ethicon Endo-Surgery, Inc. Interchangeable tools for surgical instruments
US7810692B2 (en) 2008-02-14 2010-10-12 Ethicon Endo-Surgery, Inc. Disposable loading unit with firing indicator
US8657174B2 (en) 2008-02-14 2014-02-25 Ethicon Endo-Surgery, Inc. Motorized surgical cutting and fastening instrument having handle based power source
US7819298B2 (en) 2008-02-14 2010-10-26 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with control features operable with one hand
US7866527B2 (en) 2008-02-14 2011-01-11 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with interlockable firing system
US7857185B2 (en) 2008-02-14 2010-12-28 Ethicon Endo-Surgery, Inc. Disposable loading unit for surgical stapling apparatus
US7913891B2 (en) 2008-02-14 2011-03-29 Ethicon Endo-Surgery, Inc. Disposable loading unit with user feedback features and surgical instrument for use therewith
US7959051B2 (en) 2008-02-15 2011-06-14 Ethicon Endo-Surgery, Inc. Closure systems for a surgical cutting and stapling instrument
US20090206139A1 (en) 2008-02-15 2009-08-20 Ethicon Endo-Surgery, Inc. Buttress material for a surgical instrument
US7980443B2 (en) 2008-02-15 2011-07-19 Ethicon Endo-Surgery, Inc. End effectors for a surgical cutting and stapling instrument
US20090206131A1 (en) 2008-02-15 2009-08-20 Ethicon Endo-Surgery, Inc. End effector coupling arrangements for a surgical cutting and stapling instrument
US8608044B2 (en) 2008-02-15 2013-12-17 Ethicon Endo-Surgery, Inc. Feedback and lockout mechanism for surgical instrument
US20130153641A1 (en) 2008-02-15 2013-06-20 Ethicon Endo-Surgery, Inc. Releasable layer of material and surgical end effector having the same
US7922061B2 (en) 2008-05-21 2011-04-12 Ethicon Endo-Surgery, Inc. Surgical instrument with automatically reconfigurable articulating end effector
US8226639B2 (en) 2008-06-10 2012-07-24 Tyco Healthcare Group Lp System and method for output control of electrosurgical generator
US9277961B2 (en) 2009-06-12 2016-03-08 Advanced Cardiac Therapeutics, Inc. Systems and methods of radiometrically determining a hot-spot temperature of tissue being treated
US8083120B2 (en) 2008-09-18 2011-12-27 Ethicon Endo-Surgery, Inc. End effector for use with a surgical cutting and stapling instrument
US7837080B2 (en) 2008-09-18 2010-11-23 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with device for indicating when the instrument has cut through tissue
US7832612B2 (en) 2008-09-19 2010-11-16 Ethicon Endo-Surgery, Inc. Lockout arrangement for a surgical stapler
US8540133B2 (en) 2008-09-19 2013-09-24 Ethicon Endo-Surgery, Inc. Staple cartridge
US9386983B2 (en) 2008-09-23 2016-07-12 Ethicon Endo-Surgery, Llc Robotically-controlled motorized surgical instrument
US9050083B2 (en) 2008-09-23 2015-06-09 Ethicon Endo-Surgery, Inc. Motorized surgical instrument
US8210411B2 (en) 2008-09-23 2012-07-03 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting instrument
US9005230B2 (en) 2008-09-23 2015-04-14 Ethicon Endo-Surgery, Inc. Motorized surgical instrument
US8608045B2 (en) 2008-10-10 2013-12-17 Ethicon Endo-Sugery, Inc. Powered surgical cutting and stapling apparatus with manually retractable firing system
US8020743B2 (en) 2008-10-15 2011-09-20 Ethicon Endo-Surgery, Inc. Powered articulatable surgical cutting and fastening instrument with flexible drive member
US7918377B2 (en) 2008-10-16 2011-04-05 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with apparatus for providing anvil position feedback
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
AU2009314133B2 (en) 2008-11-17 2015-12-10 Vessix Vascular, Inc. Selective accumulation of energy with or without knowledge of tissue topography
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US8808345B2 (en) 2008-12-31 2014-08-19 Medtronic Ardian Luxembourg S.A.R.L. Handle assemblies for intravascular treatment devices and associated systems and methods
EP2376011B1 (en) 2009-01-09 2019-07-03 ReCor Medical, Inc. Apparatus for treatment of mitral valve insufficiency
US8262652B2 (en) 2009-01-12 2012-09-11 Tyco Healthcare Group Lp Imaginary impedance process monitoring and intelligent shut-off
US8485413B2 (en) 2009-02-05 2013-07-16 Ethicon Endo-Surgery, Inc. Surgical stapling instrument comprising an articulation joint
US8414577B2 (en) 2009-02-05 2013-04-09 Ethicon Endo-Surgery, Inc. Surgical instruments and components for use in sterile environments
US8397971B2 (en) 2009-02-05 2013-03-19 Ethicon Endo-Surgery, Inc. Sterilizable surgical instrument
US8517239B2 (en) 2009-02-05 2013-08-27 Ethicon Endo-Surgery, Inc. Surgical stapling instrument comprising a magnetic element driver
US8453907B2 (en) 2009-02-06 2013-06-04 Ethicon Endo-Surgery, Inc. Motor driven surgical fastener device with cutting member reversing mechanism
US8444036B2 (en) 2009-02-06 2013-05-21 Ethicon Endo-Surgery, Inc. Motor driven surgical fastener device with mechanisms for adjusting a tissue gap within the end effector
JP5693471B2 (en) * 2009-02-11 2015-04-01 ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. Insulated ablation catheter device and use thereof
US8066167B2 (en) 2009-03-23 2011-11-29 Ethicon Endo-Surgery, Inc. Circular surgical stapling instrument with anvil locking system
US9750563B2 (en) 2009-09-22 2017-09-05 Mederi Therapeutics, Inc. Systems and methods for treating tissue with radiofrequency energy
JP5764564B2 (en) 2009-09-22 2015-08-19 メデリ セラピューティクス インコーポレイテッド Systems and methods for controlling the use and operation of various therapeutic device groups
US9775664B2 (en) 2009-09-22 2017-10-03 Mederi Therapeutics, Inc. Systems and methods for treating tissue with radiofrequency energy
US10386990B2 (en) 2009-09-22 2019-08-20 Mederi Rf, Llc Systems and methods for treating tissue with radiofrequency energy
US9474565B2 (en) 2009-09-22 2016-10-25 Mederi Therapeutics, Inc. Systems and methods for treating tissue with radiofrequency energy
US8685015B2 (en) * 2009-09-24 2014-04-01 Covidien Lp System and method for multi-pole phase-shifted radio frequency application
US8348129B2 (en) 2009-10-09 2013-01-08 Ethicon Endo-Surgery, Inc. Surgical stapler having a closure mechanism
US8353438B2 (en) 2009-11-19 2013-01-15 Ethicon Endo-Surgery, Inc. Circular stapler introducer with rigid cap assembly configured for easy removal
US8136712B2 (en) 2009-12-10 2012-03-20 Ethicon Endo-Surgery, Inc. Surgical stapler with discrete staple height adjustment and tactile feedback
US8220688B2 (en) 2009-12-24 2012-07-17 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting instrument with electric actuator directional control assembly
US8851354B2 (en) 2009-12-24 2014-10-07 Ethicon Endo-Surgery, Inc. Surgical cutting instrument that analyzes tissue thickness
US8267300B2 (en) 2009-12-30 2012-09-18 Ethicon Endo-Surgery, Inc. Dampening device for endoscopic surgical stapler
US8608046B2 (en) 2010-01-07 2013-12-17 Ethicon Endo-Surgery, Inc. Test device for a surgical tool
EP2525715A4 (en) * 2010-01-19 2014-06-04 Medtronic Ardian Luxembourg S R L Methods and apparatus for renal neuromodulation via stereotactic radiotherapy
US8556891B2 (en) 2010-03-03 2013-10-15 Medtronic Ablation Frontiers Llc Variable-output radiofrequency ablation power supply
WO2011115787A1 (en) * 2010-03-15 2011-09-22 Boston Scientific Scimed, Inc. Ablation catheter with isolated temperature sensing tip
US9277955B2 (en) 2010-04-09 2016-03-08 Vessix Vascular, Inc. Power generating and control apparatus for the treatment of tissue
US9192790B2 (en) 2010-04-14 2015-11-24 Boston Scientific Scimed, Inc. Focused ultrasonic renal denervation
US8870863B2 (en) 2010-04-26 2014-10-28 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
US8834388B2 (en) 2010-04-30 2014-09-16 Medtronic Ablation Frontiers Llc Method and apparatus to regulate a tissue temperature
US8473067B2 (en) 2010-06-11 2013-06-25 Boston Scientific Scimed, Inc. Renal denervation and stimulation employing wireless vascular energy transfer arrangement
US8789740B2 (en) 2010-07-30 2014-07-29 Ethicon Endo-Surgery, Inc. Linear cutting and stapling device with selectively disengageable cutting member
US8783543B2 (en) 2010-07-30 2014-07-22 Ethicon Endo-Surgery, Inc. Tissue acquisition arrangements and methods for surgical stapling devices
US9358365B2 (en) 2010-07-30 2016-06-07 Boston Scientific Scimed, Inc. Precision electrode movement control for renal nerve ablation
US9155589B2 (en) 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US8801735B2 (en) 2010-07-30 2014-08-12 Ethicon Endo-Surgery, Inc. Surgical circular stapler with tissue retention arrangements
US20120089047A1 (en) 2010-08-05 2012-04-12 Medtronic Vascular, Inc. Cryoablation apparatuses, systems, and methods for renal neuromodulation
US8360296B2 (en) 2010-09-09 2013-01-29 Ethicon Endo-Surgery, Inc. Surgical stapling head assembly with firing lockout for a surgical stapler
EP2593028B1 (en) 2010-09-15 2017-08-16 Icecure Medical Ltd. Cryosurgical instrument for treating large volume of tissue
US9289212B2 (en) 2010-09-17 2016-03-22 Ethicon Endo-Surgery, Inc. Surgical instruments and batteries for surgical instruments
US8632525B2 (en) 2010-09-17 2014-01-21 Ethicon Endo-Surgery, Inc. Power control arrangements for surgical instruments and batteries
US20120078244A1 (en) 2010-09-24 2012-03-29 Worrell Barry C Control features for articulating surgical device
US8733613B2 (en) 2010-09-29 2014-05-27 Ethicon Endo-Surgery, Inc. Staple cartridge
US9629814B2 (en) 2010-09-30 2017-04-25 Ethicon Endo-Surgery, Llc Tissue thickness compensator configured to redistribute compressive forces
US9839420B2 (en) 2010-09-30 2017-12-12 Ethicon Llc Tissue thickness compensator comprising at least one medicament
US9386984B2 (en) 2013-02-08 2016-07-12 Ethicon Endo-Surgery, Llc Staple cartridge comprising a releasable cover
US9204880B2 (en) 2012-03-28 2015-12-08 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising capsules defining a low pressure environment
US9220501B2 (en) 2010-09-30 2015-12-29 Ethicon Endo-Surgery, Inc. Tissue thickness compensators
JP6026509B2 (en) 2011-04-29 2016-11-16 エシコン・エンド−サージェリィ・インコーポレイテッドEthicon Endo−Surgery,Inc. Staple cartridge including staples disposed within a compressible portion of the staple cartridge itself
US9615826B2 (en) 2010-09-30 2017-04-11 Ethicon Endo-Surgery, Llc Multiple thickness implantable layers for surgical stapling devices
US20120080336A1 (en) 2010-09-30 2012-04-05 Ethicon Endo-Surgery, Inc. Staple cartridge comprising staples positioned within a compressible portion thereof
US9517063B2 (en) 2012-03-28 2016-12-13 Ethicon Endo-Surgery, Llc Movable member for use with a tissue thickness compensator
US9113862B2 (en) 2010-09-30 2015-08-25 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with a variable staple forming system
US9364233B2 (en) 2010-09-30 2016-06-14 Ethicon Endo-Surgery, Llc Tissue thickness compensators for circular surgical staplers
US9277919B2 (en) 2010-09-30 2016-03-08 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising fibers to produce a resilient load
US9320523B2 (en) 2012-03-28 2016-04-26 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising tissue ingrowth features
US10213198B2 (en) 2010-09-30 2019-02-26 Ethicon Llc Actuator for releasing a tissue thickness compensator from a fastener cartridge
US8893949B2 (en) 2010-09-30 2014-11-25 Ethicon Endo-Surgery, Inc. Surgical stapler with floating anvil
JP6224070B2 (en) 2012-03-28 2017-11-01 エシコン・エンド−サージェリィ・インコーポレイテッドEthicon Endo−Surgery,Inc. Retainer assembly including tissue thickness compensator
US9211120B2 (en) 2011-04-29 2015-12-15 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising a plurality of medicaments
BR112013007717A2 (en) 2010-09-30 2016-08-09 Ethicon Endo Surgery Inc System fasteners which comprises a retaining matrix array and an alignment
US9332974B2 (en) 2010-09-30 2016-05-10 Ethicon Endo-Surgery, Llc Layered tissue thickness compensator
US9314246B2 (en) 2010-09-30 2016-04-19 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorporating an anti-inflammatory agent
US9216019B2 (en) 2011-09-23 2015-12-22 Ethicon Endo-Surgery, Inc. Surgical stapler with stationary staple drivers
US9301752B2 (en) 2010-09-30 2016-04-05 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising a plurality of capsules
US8695866B2 (en) 2010-10-01 2014-04-15 Ethicon Endo-Surgery, Inc. Surgical instrument having a power control circuit
USD650074S1 (en) 2010-10-01 2011-12-06 Ethicon Endo-Surgery, Inc. Surgical instrument
US9084610B2 (en) 2010-10-21 2015-07-21 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
US9066720B2 (en) 2010-10-25 2015-06-30 Medtronic Ardian Luxembourg S.A.R.L. Devices, systems and methods for evaluation and feedback of neuromodulation treatment
RU2013123775A (en) 2010-10-25 2014-12-10 Медтроник Ардиан Люксембург С.А.Р.Л. Catheter devices containing multiple electrode groups for renal neuromodulation and related systems and methods
US8974451B2 (en) 2010-10-25 2015-03-10 Boston Scientific Scimed, Inc. Renal nerve ablation using conductive fluid jet and RF energy
WO2012061150A1 (en) 2010-10-25 2012-05-10 Medtronic Ardian Luxembourg S.a.r.I. Microwave catheter apparatuses, systems, and methods for renal neuromodulation
US9060754B2 (en) 2010-10-26 2015-06-23 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US9060755B2 (en) 2010-10-26 2015-06-23 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US9220558B2 (en) 2010-10-27 2015-12-29 Boston Scientific Scimed, Inc. RF renal denervation catheter with multiple independent electrodes
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US9668811B2 (en) 2010-11-16 2017-06-06 Boston Scientific Scimed, Inc. Minimally invasive access for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
EP2640293A4 (en) 2010-11-17 2015-05-13 Medtronic Ardian Luxembourg S R L Therapeutic renal neuromodulation for treating dyspnea and associated systems and methods
US9326751B2 (en) 2010-11-17 2016-05-03 Boston Scientific Scimed, Inc. Catheter guidance of external energy for renal denervation
US9060761B2 (en) 2010-11-18 2015-06-23 Boston Scientific Scime, Inc. Catheter-focused magnetic field induced renal nerve ablation
US9023034B2 (en) 2010-11-22 2015-05-05 Boston Scientific Scimed, Inc. Renal ablation electrode with force-activatable conduction apparatus
US9192435B2 (en) 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
US8979840B2 (en) * 2010-12-17 2015-03-17 St. Jude Medical, Atrial Fibrillation Division, Inc. Irrigant distribution system for flexible electrodes
US9855094B2 (en) 2010-12-28 2018-01-02 St. Jude Medical, Atrial Fibrillation Division, Inc. Multi-rate fluid flow and variable power delivery for ablation electrode assemblies used in catheter ablation procedures
US9788891B2 (en) 2010-12-28 2017-10-17 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation electrode assemblies and methods for using same
WO2012100095A1 (en) 2011-01-19 2012-07-26 Boston Scientific Scimed, Inc. Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury
KR20140010374A (en) * 2011-02-14 2014-01-24 시네론 메디컬 리미티드 A method and apparatus for cosmetic skin treatment
US9033204B2 (en) 2011-03-14 2015-05-19 Ethicon Endo-Surgery, Inc. Circular stapling devices with tissue-puncturing anvil features
US8857693B2 (en) 2011-03-15 2014-10-14 Ethicon Endo-Surgery, Inc. Surgical instruments with lockable articulating end effector
US8540131B2 (en) 2011-03-15 2013-09-24 Ethicon Endo-Surgery, Inc. Surgical staple cartridges with tissue tethers for manipulating divided tissue and methods of using same
US8926598B2 (en) 2011-03-15 2015-01-06 Ethicon Endo-Surgery, Inc. Surgical instruments with articulatable and rotatable end effector
US9044229B2 (en) 2011-03-15 2015-06-02 Ethicon Endo-Surgery, Inc. Surgical fastener instruments
US8800841B2 (en) 2011-03-15 2014-08-12 Ethicon Endo-Surgery, Inc. Surgical staple cartridges
US10278774B2 (en) 2011-03-18 2019-05-07 Covidien Lp Selectively expandable operative element support structure and methods of use
EP2696787B1 (en) 2011-04-12 2019-01-16 Thermedical, Inc. Devices for heating fluid in fluid enhanced ablation therapy
US9198662B2 (en) 2012-03-28 2015-12-01 Ethicon Endo-Surgery, Inc. Tissue thickness compensator having improved visibility
US9072535B2 (en) 2011-05-27 2015-07-07 Ethicon Endo-Surgery, Inc. Surgical stapling instruments with rotatable staple deployment arrangements
WO2013013156A2 (en) 2011-07-20 2013-01-24 Boston Scientific Scimed, Inc. Percutaneous devices and methods to visualize, target and ablate nerves
EP2734264B1 (en) 2011-07-22 2018-11-21 Boston Scientific Scimed, Inc. Nerve modulation system with a nerve modulation element positionable in a helical guide
US10201385B2 (en) * 2011-09-01 2019-02-12 Biosense Webster (Israel) Ltd. Catheter adapted for direct tissue contact
US8900228B2 (en) 2011-09-01 2014-12-02 Biosense Webster (Israel) Ltd. Catheter adapted for direct tissue contact and pressure sensing
US9198661B2 (en) 2011-09-06 2015-12-01 Ethicon Endo-Surgery, Inc. Stapling instrument comprising a plurality of staple cartridges stored therein
US20130261368A1 (en) 2011-09-23 2013-10-03 Alan N. Schwartz Non-invasive and minimally invasive and tightly targeted minimally invasive therapy methods and devices for parathyroid treatment
US9050084B2 (en) 2011-09-23 2015-06-09 Ethicon Endo-Surgery, Inc. Staple cartridge including collapsible deck arrangement
EP2765942B1 (en) 2011-10-10 2016-02-24 Boston Scientific Scimed, Inc. Medical devices including ablation electrodes
US9420955B2 (en) 2011-10-11 2016-08-23 Boston Scientific Scimed, Inc. Intravascular temperature monitoring system and method
US10085799B2 (en) 2011-10-11 2018-10-02 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US9364284B2 (en) 2011-10-12 2016-06-14 Boston Scientific Scimed, Inc. Method of making an off-wall spacer cage
US9162046B2 (en) 2011-10-18 2015-10-20 Boston Scientific Scimed, Inc. Deflectable medical devices
EP2768568A1 (en) 2011-10-18 2014-08-27 Boston Scientific Scimed, Inc. Integrated crossing balloon catheter
US9327123B2 (en) 2011-11-07 2016-05-03 Medtronic Ardian Luxembourg S.A.R.L. Endovascular nerve monitoring devices and associated systems and methods
CN108095821A (en) 2011-11-08 2018-06-01 波士顿科学西美德公司 Hole portion renal nerve melts
US9119600B2 (en) 2011-11-15 2015-09-01 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
US9119632B2 (en) 2011-11-21 2015-09-01 Boston Scientific Scimed, Inc. Deflectable renal nerve ablation catheter
US9192766B2 (en) 2011-12-02 2015-11-24 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation methods and devices for treatment of polycystic kidney disease
US9265969B2 (en) 2011-12-21 2016-02-23 Cardiac Pacemakers, Inc. Methods for modulating cell function
CN104254368B (en) 2011-12-23 2016-10-12 维西克斯血管公司 Tissue or body tissue via the body passageway near the reconstruction method and apparatus
EP2797534A1 (en) 2011-12-28 2014-11-05 Boston Scientific Scimed, Inc. Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US10076383B2 (en) 2012-01-25 2018-09-18 Covidien Lp Electrosurgical device having a multiplexer
US8926605B2 (en) 2012-02-07 2015-01-06 Advanced Cardiac Therapeutics, Inc. Systems and methods for radiometrically measuring temperature during tissue ablation
US9044230B2 (en) 2012-02-13 2015-06-02 Ethicon Endo-Surgery, Inc. Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status
AU2013230883A1 (en) 2012-03-07 2014-09-11 Medtronic Af Luxembourg S.A.R.L. Selective modulation of renal nerves
US9883909B2 (en) 2012-03-08 2018-02-06 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation methods and systems for treatment of hyperaldosteronism
US9974593B2 (en) 2012-03-08 2018-05-22 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation and associated systems and methods for the treatment of sexual dysfunction
US9750568B2 (en) 2012-03-08 2017-09-05 Medtronic Ardian Luxembourg S.A.R.L. Ovarian neuromodulation and associated systems and methods
US9510777B2 (en) 2012-03-08 2016-12-06 Medtronic Ardian Luxembourg S.A.R.L. Monitoring of neuromodulation using biomarkers
US9226791B2 (en) 2012-03-12 2016-01-05 Advanced Cardiac Therapeutics, Inc. Systems for temperature-controlled ablation using radiometric feedback
US9078653B2 (en) 2012-03-26 2015-07-14 Ethicon Endo-Surgery, Inc. Surgical stapling device with lockout system for preventing actuation in the absence of an installed staple cartridge
US9307989B2 (en) 2012-03-28 2016-04-12 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorportating a hydrophobic agent
CN104334098B (en) 2012-03-28 2017-03-22 伊西康内外科公司 Defining a tissue thickness compensator comprises a low pressure environment of the capsule
US8403927B1 (en) 2012-04-05 2013-03-26 William Bruce Shingleton Vasectomy devices and methods
WO2013158299A1 (en) 2012-04-18 2013-10-24 Cynosure, Inc. Picosecond laser apparatus and methods for treating target tissues with same
US9241752B2 (en) 2012-04-27 2016-01-26 Medtronic Ardian Luxembourg S.A.R.L. Shafts with pressure relief in cryotherapeutic catheters and associated devices, systems, and methods
US10258791B2 (en) 2012-04-27 2019-04-16 Medtronic Ardian Luxembourg S.A.R.L. Catheter assemblies for neuromodulation proximate a bifurcation of a renal artery and associated systems and methods
US9848950B2 (en) 2012-04-27 2017-12-26 Medtronic Ardian Luxembourg S.A.R.L. Methods and devices for localized disease treatment by ablation
US9943354B2 (en) 2012-04-27 2018-04-17 Medtronic Ardian Luxembourg S.A.R.L. Methods and devices for localized inhibition of inflammation by ablation
ES2614272T3 (en) 2012-05-11 2017-05-30 Medtronic Ardian Luxembourg S.à.r.l. Multiple electrode catheter assemblies for renal neuromodulation and associated systems and methods
US9521966B2 (en) 2012-05-17 2016-12-20 Alan N. Schwartz Localization of the parathyroid
US8954161B2 (en) 2012-06-01 2015-02-10 Advanced Cardiac Therapeutics, Inc. Systems and methods for radiometrically measuring temperature and detecting tissue contact prior to and during tissue ablation
US9101358B2 (en) 2012-06-15 2015-08-11 Ethicon Endo-Surgery, Inc. Articulatable surgical instrument comprising a firing drive
US9072536B2 (en) 2012-06-28 2015-07-07 Ethicon Endo-Surgery, Inc. Differential locking arrangements for rotary powered surgical instruments
US9226751B2 (en) 2012-06-28 2016-01-05 Ethicon Endo-Surgery, Inc. Surgical instrument system including replaceable end effectors
US9408606B2 (en) 2012-06-28 2016-08-09 Ethicon Endo-Surgery, Llc Robotically powered surgical device with manually-actuatable reversing system
US9125662B2 (en) 2012-06-28 2015-09-08 Ethicon Endo-Surgery, Inc. Multi-axis articulating and rotating surgical tools
US9028494B2 (en) 2012-06-28 2015-05-12 Ethicon Endo-Surgery, Inc. Interchangeable end effector coupling arrangement
US9282974B2 (en) 2012-06-28 2016-03-15 Ethicon Endo-Surgery, Llc Empty clip cartridge lockout
US9561038B2 (en) 2012-06-28 2017-02-07 Ethicon Endo-Surgery, Llc Interchangeable clip applier
US9289256B2 (en) 2012-06-28 2016-03-22 Ethicon Endo-Surgery, Llc Surgical end effectors having angled tissue-contacting surfaces
US20140005718A1 (en) 2012-06-28 2014-01-02 Ethicon Endo-Surgery, Inc. Multi-functional powered surgical device with external dissection features
US8747238B2 (en) 2012-06-28 2014-06-10 Ethicon Endo-Surgery, Inc. Rotary drive shaft assemblies for surgical instruments with articulatable end effectors
US9101385B2 (en) 2012-06-28 2015-08-11 Ethicon Endo-Surgery, Inc. Electrode connections for rotary driven surgical tools
US20140001231A1 (en) 2012-06-28 2014-01-02 Ethicon Endo-Surgery, Inc. Firing system lockout arrangements for surgical instruments
US20140005678A1 (en) 2012-06-28 2014-01-02 Ethicon Endo-Surgery, Inc. Rotary drive arrangements for surgical instruments
US9119657B2 (en) 2012-06-28 2015-09-01 Ethicon Endo-Surgery, Inc. Rotary actuatable closure arrangement for surgical end effector
US9364230B2 (en) 2012-06-28 2016-06-14 Ethicon Endo-Surgery, Llc Surgical stapling instruments with rotary joint assemblies
US8951296B2 (en) 2012-06-29 2015-02-10 Medtronic Ardian Luxembourg S.A.R.L. Devices and methods for photodynamically modulating neural function in a human
US10022176B2 (en) 2012-08-15 2018-07-17 Thermedical, Inc. Low profile fluid enhanced ablation therapy devices and methods
WO2014032016A1 (en) 2012-08-24 2014-02-27 Boston Scientific Scimed, Inc. Intravascular catheter with a balloon comprising separate microporous regions
US8612022B1 (en) 2012-09-13 2013-12-17 Invatec S.P.A. Neuromodulation catheters and associated systems and methods
CN104780859B (en) 2012-09-17 2017-07-25 波士顿科学西美德公司 Self-positioning electrode system and method for renal regulation
US10398464B2 (en) 2012-09-21 2019-09-03 Boston Scientific Scimed, Inc. System for nerve modulation and innocuous thermal gradient nerve block
US9386985B2 (en) 2012-10-15 2016-07-12 Ethicon Endo-Surgery, Llc Surgical cutting instrument
US20140110296A1 (en) 2012-10-19 2014-04-24 Medtronic Ardian Luxembourg S.A.R.L. Packaging for Catheter Treatment Devices and Associated Devices, Systems, and Methods
US9044575B2 (en) 2012-10-22 2015-06-02 Medtronic Adrian Luxembourg S.a.r.l. Catheters with enhanced flexibility and associated devices, systems, and methods
CN108310589A (en) 2012-10-22 2018-07-24 美敦力Af卢森堡有限责任公司 Conduit flexible with improvement
US10342510B2 (en) 2012-11-08 2019-07-09 Koninklijke Philips N.V. Interventional device, method of assembling, and assembling system
US9095321B2 (en) 2012-11-21 2015-08-04 Medtronic Ardian Luxembourg S.A.R.L. Cryotherapeutic devices having integral multi-helical balloons and methods of making the same
US9017317B2 (en) 2012-12-06 2015-04-28 Medtronic Ardian Luxembourg S.A.R.L. Refrigerant supply system for cryotherapy including refrigerant recompression and associated devices, systems, and methods
US10092292B2 (en) 2013-02-28 2018-10-09 Ethicon Llc Staple forming features for surgical stapling instrument
US9554794B2 (en) 2013-03-01 2017-01-31 Ethicon Endo-Surgery, Llc Multiple processor motor control for modular surgical instruments
JP6382235B2 (en) 2013-03-01 2018-08-29 エシコン・エンド−サージェリィ・インコーポレイテッドEthicon Endo−Surgery,Inc. Articulatable surgical instrument with a conductive path for signal communication
US9956033B2 (en) 2013-03-11 2018-05-01 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
WO2014143571A1 (en) 2013-03-11 2014-09-18 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US9345481B2 (en) 2013-03-13 2016-05-24 Ethicon Endo-Surgery, Llc Staple cartridge tissue thickness sensor system
US9808311B2 (en) 2013-03-13 2017-11-07 Boston Scientific Scimed, Inc. Deflectable medical devices
US9629623B2 (en) 2013-03-14 2017-04-25 Ethicon Endo-Surgery, Llc Drive system lockout arrangements for modular surgical instruments
US9687230B2 (en) 2013-03-14 2017-06-27 Ethicon Llc Articulatable surgical instrument comprising a firing drive
US9629629B2 (en) 2013-03-14 2017-04-25 Ethicon Endo-Surgey, LLC Control systems for surgical instruments
US9179974B2 (en) 2013-03-15 2015-11-10 Medtronic Ardian Luxembourg S.A.R.L. Helical push wire electrode
JP6139772B2 (en) 2013-03-15 2017-05-31 ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. Control unit for use with electrode pads and method for estimating leakage
US10285757B2 (en) 2013-03-15 2019-05-14 Cynosure, Llc Picosecond optical radiation systems and methods of use
US9066726B2 (en) 2013-03-15 2015-06-30 Medtronic Ardian Luxembourg S.A.R.L. Multi-electrode apposition judgment using pressure elements
US10265122B2 (en) 2013-03-15 2019-04-23 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use
US9033972B2 (en) 2013-03-15 2015-05-19 Thermedical, Inc. Methods and devices for fluid enhanced microwave ablation therapy
WO2014150553A1 (en) 2013-03-15 2014-09-25 Boston Scientific Scimed, Inc. Methods and apparatuses for remodeling tissue of or adjacent to a body passage
US9610396B2 (en) 2013-03-15 2017-04-04 Thermedical, Inc. Systems and methods for visualizing fluid enhanced ablation therapy
US9332984B2 (en) 2013-03-27 2016-05-10 Ethicon Endo-Surgery, Llc Fastener cartridge assemblies
US9795384B2 (en) 2013-03-27 2017-10-24 Ethicon Llc Fastener cartridge comprising a tissue thickness compensator and a gap setting element
US9572577B2 (en) 2013-03-27 2017-02-21 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a tissue thickness compensator including openings therein
US10405857B2 (en) 2013-04-16 2019-09-10 Ethicon Llc Powered linear surgical stapler
US10149680B2 (en) 2013-04-16 2018-12-11 Ethicon Llc Surgical instrument comprising a gap setting system
US9574644B2 (en) 2013-05-30 2017-02-21 Ethicon Endo-Surgery, Llc Power module for use with a surgical instrument
JP2016524949A (en) 2013-06-21 2016-08-22 ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. Medical device for renal nerve ablation having a rotatable shaft
JP2016523147A (en) 2013-06-21 2016-08-08 ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. Renal denervation balloon catheter with a riding-type electrode support
US9707036B2 (en) 2013-06-25 2017-07-18 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation using localized indifferent electrodes
AU2014284558B2 (en) 2013-07-01 2017-08-17 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
WO2015006573A1 (en) 2013-07-11 2015-01-15 Boston Scientific Scimed, Inc. Medical device with stretchable electrode assemblies
WO2015010074A1 (en) 2013-07-19 2015-01-22 Boston Scientific Scimed, Inc. Spiral bipolar electrode renal denervation balloon
CN105555220B (en) 2013-07-22 2019-05-17 波士顿科学国际有限公司 Medical instrument for renal nerve ablation
US9872719B2 (en) 2013-07-24 2018-01-23 Covidien Lp Systems and methods for generating electrosurgical energy using a multistage power converter
US9655670B2 (en) 2013-07-29 2017-05-23 Covidien Lp Systems and methods for measuring tissue impedance through an electrosurgical cable
US20150053743A1 (en) 2013-08-23 2015-02-26 Ethicon Endo-Surgery, Inc. Error detection arrangements for surgical instrument assemblies
US9326816B2 (en) 2013-08-30 2016-05-03 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation systems having nerve monitoring assemblies and associated devices, systems, and methods
US9339332B2 (en) 2013-08-30 2016-05-17 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation catheters with nerve monitoring features for transmitting digital neural signals and associated systems and methods
US9895194B2 (en) 2013-09-04 2018-02-20 Boston Scientific Scimed, Inc. Radio frequency (RF) balloon catheter having flushing and cooling capability
US9138578B2 (en) 2013-09-10 2015-09-22 Medtronic Ardian Luxembourg S.A.R.L. Endovascular catheters with tuned control members and associated systems and methods
CN105592778B (en) 2013-10-14 2019-07-23 波士顿科学医学有限公司 High-resolution cardiac mapping electrod-array conduit
AU2014334574B2 (en) 2013-10-15 2017-07-06 Boston Scientific Scimed, Inc. Medical device balloon
US9770606B2 (en) 2013-10-15 2017-09-26 Boston Scientific Scimed, Inc. Ultrasound ablation catheter with cooling infusion and centering basket
US10433902B2 (en) * 2013-10-23 2019-10-08 Medtronic Ardian Luxembourg S.A.R.L. Current control methods and systems
US10271898B2 (en) 2013-10-25 2019-04-30 Boston Scientific Scimed, Inc. Embedded thermocouple in denervation flex circuit
US20150126995A1 (en) * 2013-11-06 2015-05-07 Biosense Webster (Israel) Ltd. Using catheter position and temperature measurement to detect movement from ablation point
US9642620B2 (en) 2013-12-23 2017-05-09 Ethicon Endo-Surgery, Llc Surgical cutting and stapling instruments with articulatable end effectors
US9687232B2 (en) 2013-12-23 2017-06-27 Ethicon Llc Surgical staples
US9724092B2 (en) 2013-12-23 2017-08-08 Ethicon Llc Modular surgical instruments
US9681870B2 (en) 2013-12-23 2017-06-20 Ethicon Llc Articulatable surgical instruments with separate and distinct closing and firing systems
US9839428B2 (en) 2013-12-23 2017-12-12 Ethicon Llc Surgical cutting and stapling instruments with independent jaw control features
WO2015113034A1 (en) 2014-01-27 2015-07-30 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation catheters having jacketed neuromodulation elements and related devices, systems, and methods
CN106572881B (en) 2014-02-04 2019-07-26 波士顿科学国际有限公司 Substitution of the heat sensor on bipolar electrode is placed
US9962161B2 (en) 2014-02-12 2018-05-08 Ethicon Llc Deliverable surgical instrument
JP6462004B2 (en) 2014-02-24 2019-01-30 エシコン エルエルシー Fastening system with launcher lockout
US9757124B2 (en) 2014-02-24 2017-09-12 Ethicon Llc Implantable layer assemblies
US9579149B2 (en) 2014-03-13 2017-02-28 Medtronic Ardian Luxembourg S.A.R.L. Low profile catheter assemblies and associated systems and methods
US9743929B2 (en) 2014-03-26 2017-08-29 Ethicon Llc Modular powered surgical instrument with detachable shaft assemblies
US9733663B2 (en) 2014-03-26 2017-08-15 Ethicon Llc Power management through segmented circuit and variable voltage protection
US9913642B2 (en) 2014-03-26 2018-03-13 Ethicon Llc Surgical instrument comprising a sensor system
US10004497B2 (en) 2014-03-26 2018-06-26 Ethicon Llc Interface systems for use with surgical instruments
US10194979B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9980766B1 (en) 2014-03-28 2018-05-29 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for renal neuromodulation
US10194980B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US20150297229A1 (en) 2014-04-16 2015-10-22 Ethicon Endo-Surgery, Inc. Fastener cartridge comprising deployable tissue engaging members
US10045781B2 (en) 2014-06-13 2018-08-14 Ethicon Llc Closure lockout systems for surgical instruments
US9788836B2 (en) 2014-09-05 2017-10-17 Ethicon Llc Multiple motor control for powered medical device
US9801627B2 (en) 2014-09-26 2017-10-31 Ethicon Llc Fastener cartridge for creating a flexible staple line
US9943310B2 (en) 2014-09-26 2018-04-17 Ethicon Llc Surgical stapling buttresses and adjunct materials
US10368775B2 (en) 2014-10-01 2019-08-06 Medtronic Ardian Luxembourg S.A.R.L. Systems and methods for evaluating neuromodulation therapy via hemodynamic responses
US10076325B2 (en) 2014-10-13 2018-09-18 Ethicon Llc Surgical stapling apparatus comprising a tissue stop
US9924944B2 (en) 2014-10-16 2018-03-27 Ethicon Llc Staple cartridge comprising an adjunct material
US9844376B2 (en) 2014-11-06 2017-12-19 Ethicon Llc Staple cartridge comprising a releasable adjunct material
EP3220843A4 (en) 2014-11-19 2018-07-25 Advanced Cardiac Therapeutics, Inc. Ablation devices, systems and methods of using a high-resolution electrode assembly
AU2015350007A1 (en) 2014-11-19 2017-06-29 Epix Therapeutics, Inc. Systems and methods for high-resolution mapping of tissue
JP2017534407A (en) 2014-11-19 2017-11-24 アドバンスド カーディアク セラピューティクス,インコーポレイテッド High resolution mapping of tissue with pacing
US10117649B2 (en) 2014-12-18 2018-11-06 Ethicon Llc Surgical instrument assembly comprising a lockable articulation system
US9844375B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Drive arrangements for articulatable surgical instruments
US10188385B2 (en) 2014-12-18 2019-01-29 Ethicon Llc Surgical instrument system comprising lockable systems
US9987000B2 (en) 2014-12-18 2018-06-05 Ethicon Llc Surgical instrument assembly comprising a flexible articulation system
US9844374B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member
US10085748B2 (en) 2014-12-18 2018-10-02 Ethicon Llc Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors
US9968355B2 (en) 2014-12-18 2018-05-15 Ethicon Llc Surgical instruments with articulatable end effectors and improved firing beam support arrangements
US9119628B1 (en) 2015-01-21 2015-09-01 Serene Medical, Inc. Systems and devices to identify and limit nerve conduction
US9113912B1 (en) 2015-01-21 2015-08-25 Serene Medical, Inc. Systems and devices to identify and limit nerve conduction
US10045779B2 (en) 2015-02-27 2018-08-14 Ethicon Llc Surgical instrument system comprising an inspection station
US10180463B2 (en) 2015-02-27 2019-01-15 Ethicon Llc Surgical apparatus configured to assess whether a performance parameter of the surgical apparatus is within an acceptable performance band
US9993258B2 (en) 2015-02-27 2018-06-12 Ethicon Llc Adaptable surgical instrument handle
US9924961B2 (en) 2015-03-06 2018-03-27 Ethicon Endo-Surgery, Llc Interactive feedback system for powered surgical instruments
US10045776B2 (en) 2015-03-06 2018-08-14 Ethicon Llc Control techniques and sub-processor contained within modular shaft with select control processing from handle
US9895148B2 (en) 2015-03-06 2018-02-20 Ethicon Endo-Surgery, Llc Monitoring speed control and precision incrementing of motor for powered surgical instruments
US10052044B2 (en) 2015-03-06 2018-08-21 Ethicon Llc Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US9901342B2 (en) 2015-03-06 2018-02-27 Ethicon Endo-Surgery, Llc Signal and power communication system positioned on a rotatable shaft
US9808246B2 (en) 2015-03-06 2017-11-07 Ethicon Endo-Surgery, Llc Method of operating a powered surgical instrument
US10245033B2 (en) 2015-03-06 2019-04-02 Ethicon Llc Surgical instrument comprising a lockable battery housing
US9993248B2 (en) 2015-03-06 2018-06-12 Ethicon Endo-Surgery, Llc Smart sensors with local signal processing
US9636164B2 (en) 2015-03-25 2017-05-02 Advanced Cardiac Therapeutics, Inc. Contact sensing systems and methods
US20160287326A1 (en) * 2015-03-31 2016-10-06 St. Jude Medical, Cardiology Division, Inc. Methods and devices for delivering pulsed RF energy during catheter ablation
US10390825B2 (en) 2015-03-31 2019-08-27 Ethicon Llc Surgical instrument with progressive rotary drive systems
US10433844B2 (en) 2015-03-31 2019-10-08 Ethicon Llc Surgical instrument with selectively disengageable threaded drive systems
US10285754B2 (en) * 2015-05-18 2019-05-14 Biosense Webster (Israel) Ltd. Catheter with coaxial thermocouple
US10178992B2 (en) 2015-06-18 2019-01-15 Ethicon Llc Push/pull articulation drive systems for articulatable surgical instruments
US10028744B2 (en) 2015-08-26 2018-07-24 Ethicon Llc Staple cartridge assembly including staple guides
US10314587B2 (en) 2015-09-02 2019-06-11 Ethicon Llc Surgical staple cartridge with improved staple driver configurations
US10105139B2 (en) 2015-09-23 2018-10-23 Ethicon Llc Surgical stapler having downstream current-based motor control
US10327769B2 (en) 2015-09-23 2019-06-25 Ethicon Llc Surgical stapler having motor control based on a drive system component
US10363036B2 (en) 2015-09-23 2019-07-30 Ethicon Llc Surgical stapler having force-based motor control
US10238386B2 (en) 2015-09-23 2019-03-26 Ethicon Llc Surgical stapler having motor control based on an electrical parameter related to a motor current
US10076326B2 (en) 2015-09-23 2018-09-18 Ethicon Llc Surgical stapler having current mirror-based motor control
US10085751B2 (en) 2015-09-23 2018-10-02 Ethicon Llc Surgical stapler having temperature-based motor control
US10299878B2 (en) 2015-09-25 2019-05-28 Ethicon Llc Implantable adjunct systems for determining adjunct skew
US20170086843A1 (en) 2015-09-30 2017-03-30 Ethicon Endo-Surgery, Llc Compressible adjunct with attachment regions
US10292704B2 (en) 2015-12-30 2019-05-21 Ethicon Llc Mechanisms for compensating for battery pack failure in powered surgical instruments
US10265068B2 (en) 2015-12-30 2019-04-23 Ethicon Llc Surgical instruments with separable motors and motor control circuits
US10368865B2 (en) 2015-12-30 2019-08-06 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US20170224331A1 (en) 2016-02-09 2017-08-10 Ethicon Endo-Surgery, Llc Surgical instruments with an end effector that is highly articulatable relative to an elongate shaft assembly
US10258331B2 (en) 2016-02-12 2019-04-16 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US20170231627A1 (en) 2016-02-12 2017-08-17 Ethicon Endo-Surgery, Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
EP3429462A1 (en) 2016-03-15 2019-01-23 EPiX Therapeutics, Inc. Improved devices, systems and methods for irrigated ablation
WO2017165193A1 (en) * 2016-03-21 2017-09-28 St. Jude Medical, Cardiology Division, Inc. Multiple thermocouple assembly with reduced wire count
US10413297B2 (en) 2016-04-01 2019-09-17 Ethicon Llc Surgical stapling system configured to apply annular rows of staples having different heights
US10413293B2 (en) 2016-04-01 2019-09-17 Ethicon Llc Interchangeable surgical tool assembly with a surgical end effector that is selectively rotatable about a shaft axis
US10433849B2 (en) 2016-04-01 2019-10-08 Ethicon Llc Surgical stapling system comprising a display including a re-orientable display field
US10405859B2 (en) 2016-04-15 2019-09-10 Ethicon Llc Surgical instrument with adjustable stop/start control during a firing motion
US10335145B2 (en) 2016-04-15 2019-07-02 Ethicon Llc Modular surgical instrument with configurable operating mode
US10426467B2 (en) 2016-04-15 2019-10-01 Ethicon Llc Surgical instrument with detection sensors
US10456137B2 (en) 2016-04-15 2019-10-29 Ethicon Llc Staple formation detection mechanisms
US10357247B2 (en) 2016-04-15 2019-07-23 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US10363037B2 (en) 2016-04-18 2019-07-30 Ethicon Llc Surgical instrument system comprising a magnetic lockout
USD850617S1 (en) 2016-06-24 2019-06-04 Ethicon Llc Surgical fastener cartridge
USD847989S1 (en) 2016-06-24 2019-05-07 Ethicon Llc Surgical fastener cartridge
US9743984B1 (en) 2016-08-11 2017-08-29 Thermedical, Inc. Devices and methods for delivering fluid to tissue during ablation therapy
US10231784B2 (en) 2016-10-28 2019-03-19 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for optimizing perivascular neuromodulation therapy using computational fluid dynamics
US10426471B2 (en) 2016-12-21 2019-10-01 Ethicon Llc Surgical instrument with multiple failure response modes
US20180168614A1 (en) 2016-12-21 2018-06-21 Ethicon Endo-Surgery, Llc Anvil arrangements for surgical staplers
US10327767B2 (en) 2017-06-20 2019-06-25 Ethicon Llc Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation
US10390841B2 (en) 2017-06-20 2019-08-27 Ethicon Llc Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation
US10307170B2 (en) 2017-06-20 2019-06-04 Ethicon Llc Method for closed loop control of motor velocity of a surgical stapling and cutting instrument
US10368864B2 (en) 2017-06-20 2019-08-06 Ethicon Llc Systems and methods for controlling displaying motor velocity for a surgical instrument
US10211586B2 (en) 2017-06-28 2019-02-19 Ethicon Llc Surgical shaft assemblies with watertight housings
USD851762S1 (en) 2017-06-28 2019-06-18 Ethicon Llc Anvil
USD854151S1 (en) 2017-06-28 2019-07-16 Ethicon Llc Surgical instrument shaft
US10398434B2 (en) 2017-06-29 2019-09-03 Ethicon Llc Closed loop velocity control of closure member for robotic surgical instrument
US10258418B2 (en) 2017-06-29 2019-04-16 Ethicon Llc System for controlling articulation forces

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215275A (en) * 1977-12-07 1980-07-29 Luxtron Corporation Optical temperature measurement technique utilizing phosphors
DE2736113C2 (en) * 1977-08-10 1987-02-12 Erbe Elektromedizin Gmbh, 7400 Tuebingen, De
DE2801833C2 (en) * 1978-01-17 1979-11-29 Aesculap-Werke Ag Vormals Jetter & Scheerer, 7200 Tuttlingen
US4196734A (en) * 1978-02-16 1980-04-08 Valleylab, Inc. Combined electrosurgery/cautery system and method
US4397314A (en) * 1981-08-03 1983-08-09 Clini-Therm Corporation Method and apparatus for controlling and optimizing the heating pattern for a hyperthermia system
DE3480462D1 (en) * 1983-09-13 1989-12-21 Valleylab Inc Electrosurgical generator
US4627436A (en) * 1984-03-01 1986-12-09 Innoventions Biomedical Inc. Angioplasty catheter and method for use thereof
US4692685A (en) * 1984-03-14 1987-09-08 Blaze Kevin L Electrical measuring apparatus, and methods for determining the condition or identity of biological material
US4800899A (en) * 1984-10-22 1989-01-31 Microthermia Technology, Inc. Apparatus for destroying cells in tumors and the like
US4681122A (en) * 1985-09-23 1987-07-21 Victory Engineering Corp. Stereotaxic catheter for microwave thermotherapy
US4691703A (en) * 1986-04-25 1987-09-08 Board Of Regents, University Of Washington Thermal cautery system
IL78756D0 (en) * 1986-05-12 1986-08-31 Biodan Medical Systems Ltd Catheter and probe
DE3775281D1 (en) * 1986-06-16 1992-01-30 Siemens Ag An apparatus for controlling a heart pacemaker koerpergeweben by means of impedance measurement.
JPH0363915B2 (en) * 1987-03-05 1991-10-03 Norio Daikuzono
US4860744A (en) * 1987-11-02 1989-08-29 Raj K. Anand Thermoelectrically controlled heat medical catheter
GB2213381B (en) * 1987-12-12 1992-06-03 Univ Wales Medicine Surgical diathermy instruments
US4907589A (en) * 1988-04-29 1990-03-13 Cosman Eric R Automatic over-temperature control apparatus for a therapeutic heating device
EP0415997A4 (en) * 1988-05-18 1992-04-08 Kasevich Associates, Inc. Microwave balloon angioplasty
US4998933A (en) * 1988-06-10 1991-03-12 Advanced Angioplasty Products, Inc. Thermal angioplasty catheter and method
US4960109A (en) * 1988-06-21 1990-10-02 Massachusetts Institute Of Technology Multi-purpose temperature sensing probe for hyperthermia therapy
US4967765A (en) * 1988-07-28 1990-11-06 Bsd Medical Corporation Urethral inserted applicator for prostate hyperthermia
US4955377A (en) * 1988-10-28 1990-09-11 Lennox Charles D Device and method for heating tissue in a patient's body
US4966597A (en) * 1988-11-04 1990-10-30 Cosman Eric R Thermometric cardiac tissue ablation electrode with ultra-sensitive temperature detection
US4961047A (en) * 1988-11-10 1990-10-02 Smiths Industries Public Limited Company Electrical power control apparatus and methods
DE3838840C2 (en) * 1988-11-17 1997-02-20 Leibinger Gmbh Hochfrequenzkoagulationsvorrichtung for surgical purposes
US4945912A (en) * 1988-11-25 1990-08-07 Sensor Electronics, Inc. Catheter with radiofrequency heating applicator
US4938761A (en) * 1989-03-06 1990-07-03 Mdt Corporation Bipolar electrosurgical forceps
US4979948A (en) * 1989-04-13 1990-12-25 Purdue Research Foundation Method and apparatus for thermally destroying a layer of an organ
US5114423A (en) * 1989-05-15 1992-05-19 Advanced Cardiovascular Systems, Inc. Dilatation catheter assembly with heated balloon
US5035694A (en) * 1989-05-15 1991-07-30 Advanced Cardiovascular Systems, Inc. Dilatation catheter assembly with heated balloon
US5006119A (en) * 1989-05-25 1991-04-09 Engineering & Research Associates, Inc. Hollow core coaxial catheter
US5084044A (en) * 1989-07-14 1992-01-28 Ciron Corporation Apparatus for endometrial ablation and method of using same
US5057105A (en) * 1989-08-28 1991-10-15 The University Of Kansas Med Center Hot tip catheter assembly
JP3046315B2 (en) * 1989-09-05 2000-05-29 株式会社エス・エル・ティ・ジャパン Laser light irradiation apparatus
US5122137A (en) * 1990-04-27 1992-06-16 Boston Scientific Corporation Temperature controlled rf coagulation
US5233515A (en) * 1990-06-08 1993-08-03 Cosman Eric R Real-time graphic display of heat lesioning parameters in a clinical lesion generator system

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2856935A1 (en) 2013-09-26 2015-04-08 Biotronik AG Medical device for evaluating a temperature signal

Also Published As

Publication number Publication date
WO1993008755A1 (en) 1993-05-13
EP0566725A1 (en) 1993-10-27
US5456682A (en) 1995-10-10
DE69233091D1 (en) 2003-07-10
ES2201051T3 (en) 2004-03-16
CA2106410C (en) 2004-07-06
JPH08503381A (en) 1996-04-16
EP0566725A4 (en) 1995-02-22
AT241938T (en) 2003-06-15
US5897552A (en) 1999-04-27
US5688266A (en) 1997-11-18
DE69233091T2 (en) 2004-05-06
JP3530528B2 (en) 2004-05-24
CA2106410A1 (en) 1993-05-09
AU3067292A (en) 1993-06-07

Similar Documents

Publication Publication Date Title
AU686173B2 (en) Transurethral radio frequency ablation apparatus
US7244257B2 (en) Electrosurgical pencil having a single button variable control
US6132426A (en) Temperature and current limited ablation catheter
US6312428B1 (en) Methods and apparatus for therapeutic cauterization of predetermined volumes of biological tissue
EP0634910B1 (en) Radiofrequency system for ablation of cardiac tissue
EP1772109B1 (en) System for performing cardiac ablation
EP1080682B1 (en) System for electrosurgical cutting and ablation
US6494880B1 (en) Systems and methods for controlling power in an electrosurgical probe
EP0697841B2 (en) Apparatus for surgical cutting
EP1620156B1 (en) Multi-functional medical catheter
US6989010B2 (en) Ablation system and method of use
US5863290A (en) Multiple antenna ablation apparatus and method
US5697909A (en) Methods and apparatus for surgical cutting
US7842033B2 (en) Methods, systems, and devices for performing electrosurgical procedures
US5891095A (en) Electrosurgical treatment of tissue in electrically conductive fluid
US8382749B2 (en) Temperature monitoring return electrode
US6611793B1 (en) Systems and methods to identify and disable re-use single use devices based on detecting environmental changes
US5836990A (en) Method and apparatus for determining electrode/tissue contact
EP1990019B1 (en) Adjustable impedance electrosurgical electrodes
US7169143B2 (en) Methods for electrosurgical tissue treatment in electrically conductive fluid
EP0739189B1 (en) Radiofrequency ablation system
US4776334A (en) Catheter for treatment of tumors
DE69928439T2 (en) Internal mechanism for displacing a movable electrode
EP0694291B1 (en) Apparatus for electrosurgically treating tissue
US6651669B1 (en) Systems and methods to identify and disable re-used single use devices based on cataloging catheter usage

Legal Events

Date Code Title Description
AK Designated contracting states:

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE

17P Request for examination filed

Effective date: 19931112

AK Designated contracting states:

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE

A4 Despatch of supplementary search report
17Q First examination report

Effective date: 19961025

RAP1 Transfer of rights of an ep published application

Owner name: BOSTON SCIENTIFIC LIMITED

AK Designated contracting states:

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE

PG25 Lapsed in a contracting state announced via postgrant inform. from nat. office to epo

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030604

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030604

Ref country code: LI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030604

Ref country code: CH

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030604

RIC1 Classification (correction)

Ipc: 7A 61B 18/12 B

Ipc: 7A 61B 18/08 B

Ipc: 7A 61B 18/00 A

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REF Corresponds to:

Ref document number: 69233091

Country of ref document: DE

Date of ref document: 20030710

Kind code of ref document: P

PG25 Lapsed in a contracting state announced via postgrant inform. from nat. office to epo

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030904

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030904

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030904

PG25 Lapsed in a contracting state announced via postgrant inform. from nat. office to epo

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20031105

PG25 Lapsed in a contracting state announced via postgrant inform. from nat. office to epo

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20031130

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2201051

Country of ref document: ES

Kind code of ref document: T3

ET Fr: translation filed
26N No opposition filed

Effective date: 20040305

PGFP Postgrant: annual fees paid to national office

Ref country code: ES

Payment date: 20061116

Year of fee payment: 15

PGFP Postgrant: annual fees paid to national office

Ref country code: GB

Payment date: 20071005

Year of fee payment: 16

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20071106

PG25 Lapsed in a contracting state announced via postgrant inform. from nat. office to epo

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20071106

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20081105

PG25 Lapsed in a contracting state announced via postgrant inform. from nat. office to epo

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20081105

PGFP Postgrant: annual fees paid to national office

Ref country code: IE

Payment date: 20101028

Year of fee payment: 19

Ref country code: FR

Payment date: 20101109

Year of fee payment: 19

Ref country code: NL

Payment date: 20101025

Year of fee payment: 19

PGFP Postgrant: annual fees paid to national office

Ref country code: DE

Payment date: 20101130

Year of fee payment: 19

PGFP Postgrant: annual fees paid to national office

Ref country code: IT

Payment date: 20101118

Year of fee payment: 19

REG Reference to a national code

Ref country code: NL

Ref legal event code: V1

Effective date: 20120601

PG25 Lapsed in a contracting state announced via postgrant inform. from nat. office to epo

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120601

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20120731

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state announced via postgrant inform. from nat. office to epo

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20111105

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 69233091

Country of ref document: DE

Effective date: 20120601

PG25 Lapsed in a contracting state announced via postgrant inform. from nat. office to epo

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20111105

PG25 Lapsed in a contracting state announced via postgrant inform. from nat. office to epo

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20111130

PG25 Lapsed in a contracting state announced via postgrant inform. from nat. office to epo

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120601