WO2009057282A1 - 骨吸収抑制用食品素材 - Google Patents

骨吸収抑制用食品素材 Download PDF

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Publication number
WO2009057282A1
WO2009057282A1 PCT/JP2008/003066 JP2008003066W WO2009057282A1 WO 2009057282 A1 WO2009057282 A1 WO 2009057282A1 JP 2008003066 W JP2008003066 W JP 2008003066W WO 2009057282 A1 WO2009057282 A1 WO 2009057282A1
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
milk protein
bone resorption
protein fraction
inhibiting bone
Prior art date
Application number
PCT/JP2008/003066
Other languages
English (en)
French (fr)
Inventor
Atsushi Serizawa
Yoshikazu Morita
Daisuke Uetsuji
Aiko Ono
Hiroaki Matsuyama
Satoshi Higurashi
Original Assignee
Snow Brand Milk Products Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Snow Brand Milk Products Co., Ltd. filed Critical Snow Brand Milk Products Co., Ltd.
Priority to KR1020107012033A priority Critical patent/KR101441728B1/ko
Priority to JP2009538921A priority patent/JPWO2009057282A1/ja
Priority to AU2008320272A priority patent/AU2008320272B2/en
Priority to US12/740,711 priority patent/US8580740B2/en
Priority to CN200880114098A priority patent/CN101868475A/zh
Priority to NZ585093A priority patent/NZ585093A/xx
Priority to EP08843536.7A priority patent/EP2208733A4/en
Priority to CA2704042A priority patent/CA2704042C/en
Publication of WO2009057282A1 publication Critical patent/WO2009057282A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A—HUMAN NECESSITIES
    • A21—BAKING; EDIBLE DOUGHS
    • A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
    • A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
    • A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
    • A21D2/24—Organic nitrogen compounds
    • A21D2/26—Proteins
    • A21D2/261—Animal proteins
    • A21D2/263—Animal proteins from dairy products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C19/00—Cheese; Cheese preparations; Making thereof
    • A23C19/06—Treating cheese curd after whey separation; Products obtained thereby
    • A23C19/068—Particular types of cheese
    • A23C19/08—Process cheese preparations; Making thereof, e.g. melting, emulsifying, sterilizing
    • A23C19/082—Adding substances to the curd before or during melting; Melting salts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
    • A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
    • A23J3/343—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/385—Concentrates of non-alcoholic beverages
    • A23L2/39—Dry compositions
    • A23L2/395—Dry compositions in a particular shape or form
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/66—Proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20—Milk; Whey; Colostrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Birds (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

　次の(1)～(4)の特性を有する乳タンパク質画分は骨吸収抑制作用に優れており、骨疾患の予防又は治療に有用である。 　(1) 乳由来であること。 　(2)分子量12,000～16,000ダルトンの範囲のタンパク質を含有する画分であること。 　(3) 構成アミノ酸組成中に塩基性アミノ酸を18～20重量％含有し、かつ、塩基性アミノ酸/酸性アミノ酸比が0.7～0.9の範囲であること。 　(4) 骨吸収抑制作用を有すること。
PCT/JP2008/003066 2007-11-01 2008-10-28 骨吸収抑制用食品素材 WO2009057282A1 (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
KR1020107012033A KR101441728B1 (ko) 2007-11-01 2008-10-28 골흡수 억제용 식품 소재
JP2009538921A JPWO2009057282A1 (ja) 2007-11-01 2008-10-28 骨吸収抑制用食品素材
AU2008320272A AU2008320272B2 (en) 2007-11-01 2008-10-28 Food material for inhibiting bone resorption
US12/740,711 US8580740B2 (en) 2007-11-01 2008-10-28 Bone resorption inhibitory food material for inhibiting bone resorption
CN200880114098A CN101868475A (zh) 2007-11-01 2008-10-28 骨吸收抑制用食品原材料
NZ585093A NZ585093A (en) 2007-11-01 2008-10-28 Food material for inhibiting bone resorption
EP08843536.7A EP2208733A4 (en) 2007-11-01 2008-10-28 FOOD FOR INHIBITING BONE RESORPTION
CA2704042A CA2704042C (en) 2007-11-01 2008-10-28 Bone resorption inhibitory food material for inhibiting bone resorption

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-285408 2007-11-01
JP2007285408 2007-11-01

Publications (1)

Publication Number Publication Date
WO2009057282A1 true WO2009057282A1 (ja) 2009-05-07

Family

ID=40590689

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/003066 WO2009057282A1 (ja) 2007-11-01 2008-10-28 骨吸収抑制用食品素材

Country Status (9)

Country Link
US (1) US8580740B2 (ja)
EP (1) EP2208733A4 (ja)
JP (1) JPWO2009057282A1 (ja)
KR (1) KR101441728B1 (ja)
CN (1) CN101868475A (ja)
AU (1) AU2008320272B2 (ja)
CA (1) CA2704042C (ja)
NZ (1) NZ585093A (ja)
WO (1) WO2009057282A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012043712A1 (ja) * 2010-09-30 2012-04-05 雪印メグミルク株式会社 皮膚コラーゲン産生促進剤
WO2013133326A1 (ja) * 2012-03-09 2013-09-12 雪印メグミルク株式会社 骨強化剤

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2547402T3 (es) * 2007-11-01 2015-10-06 Megmilk Snow Brand Co., Ltd. Composiciones para fortalecer los huesos

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61246198A (ja) 1985-02-07 1986-11-01 オレオフイナ・ソシエテ・アノニム 蛋白の精製法
JPS63255300A (ja) 1987-04-10 1988-10-21 Snow Brand Milk Prod Co Ltd 硫酸エステル化物を用いて乳からラクトフエリンを分離、精製する方法
JPS6486839A (en) 1987-06-19 1989-03-31 Entamonto Sa Method for selectively extracting metal protein from whey
JPH05202098A (ja) 1992-01-29 1993-08-10 Snow Brand Milk Prod Co Ltd 乳質原料から生理活性物質の製造法
JPH05320066A (ja) 1992-05-07 1993-12-03 Snow Brand Milk Prod Co Ltd 乳清由来の骨芽細胞増殖促進及び骨強化因子ならびに該因子を含有せしめた骨強化食品、医薬および飼料
JPH08151331A (ja) * 1994-09-30 1996-06-11 Snow Brand Milk Prod Co Ltd 骨強化剤
JPH107585A (ja) * 1996-06-20 1998-01-13 Snow Brand Milk Prod Co Ltd 骨形成促進及び骨吸収防止剤
JP3092874B2 (ja) 1991-12-26 2000-09-25 雪印乳業株式会社 乳清由来の骨芽細胞増殖・骨強化画分及び該画分を含有する骨強化食品、飼料、薬品類
JP3160862B2 (ja) 1990-11-15 2001-04-25 雪印乳業株式会社 骨強化食品、飼料及び医薬
JP2001346519A (ja) * 2000-06-09 2001-12-18 Snow Brand Milk Prod Co Ltd 乳塩基性シスタチン高含有画分及びその分解物の製造方法
JP2004115509A (ja) * 2002-09-05 2004-04-15 Snow Brand Milk Prod Co Ltd 破骨細胞分化抑制因子産生促進剤
JP2005060321A (ja) * 2003-08-15 2005-03-10 Snow Brand Milk Prod Co Ltd 骨形成促進剤

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JPH03112637A (ja) 1989-09-27 1991-05-14 Hitachi Chem Co Ltd 接着剤付き化粧板及びその製造方法
JPH03160862A (ja) 1989-11-17 1991-07-10 Fujitsu Ltd 予約情報確認方式
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61246198A (ja) 1985-02-07 1986-11-01 オレオフイナ・ソシエテ・アノニム 蛋白の精製法
JPS63255300A (ja) 1987-04-10 1988-10-21 Snow Brand Milk Prod Co Ltd 硫酸エステル化物を用いて乳からラクトフエリンを分離、精製する方法
JPS6486839A (en) 1987-06-19 1989-03-31 Entamonto Sa Method for selectively extracting metal protein from whey
JP3160862B2 (ja) 1990-11-15 2001-04-25 雪印乳業株式会社 骨強化食品、飼料及び医薬
JP3092874B2 (ja) 1991-12-26 2000-09-25 雪印乳業株式会社 乳清由来の骨芽細胞増殖・骨強化画分及び該画分を含有する骨強化食品、飼料、薬品類
JPH05202098A (ja) 1992-01-29 1993-08-10 Snow Brand Milk Prod Co Ltd 乳質原料から生理活性物質の製造法
JPH05320066A (ja) 1992-05-07 1993-12-03 Snow Brand Milk Prod Co Ltd 乳清由来の骨芽細胞増殖促進及び骨強化因子ならびに該因子を含有せしめた骨強化食品、医薬および飼料
JPH08151331A (ja) * 1994-09-30 1996-06-11 Snow Brand Milk Prod Co Ltd 骨強化剤
JP3112637B2 (ja) 1994-09-30 2000-11-27 雪印乳業株式会社 骨強化剤
JPH107585A (ja) * 1996-06-20 1998-01-13 Snow Brand Milk Prod Co Ltd 骨形成促進及び骨吸収防止剤
JP2001346519A (ja) * 2000-06-09 2001-12-18 Snow Brand Milk Prod Co Ltd 乳塩基性シスタチン高含有画分及びその分解物の製造方法
JP2004115509A (ja) * 2002-09-05 2004-04-15 Snow Brand Milk Prod Co Ltd 破骨細胞分化抑制因子産生促進剤
JP2005060321A (ja) * 2003-08-15 2005-03-10 Snow Brand Milk Prod Co Ltd 骨形成促進剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Y. TAKADA ET AL., BONE AND MINERAL, vol. 17, 1992, pages 347 - 359

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012043712A1 (ja) * 2010-09-30 2012-04-05 雪印メグミルク株式会社 皮膚コラーゲン産生促進剤
JP2012077016A (ja) * 2010-09-30 2012-04-19 Snow Brand Milk Products Co Ltd 皮膚コラーゲン産生促進剤
WO2013133326A1 (ja) * 2012-03-09 2013-09-12 雪印メグミルク株式会社 骨強化剤
JP2013184960A (ja) * 2012-03-09 2013-09-19 Snow Brand Milk Products Co Ltd 骨強化剤

Also Published As

Publication number Publication date
CA2704042A1 (en) 2009-05-07
NZ585093A (en) 2013-03-28
US20100261883A1 (en) 2010-10-14
AU2008320272A1 (en) 2009-05-07
JPWO2009057282A1 (ja) 2011-03-10
US8580740B2 (en) 2013-11-12
CA2704042C (en) 2017-06-20
EP2208733A4 (en) 2014-08-06
KR101441728B1 (ko) 2014-09-17
KR20100105561A (ko) 2010-09-29
EP2208733A1 (en) 2010-07-21
AU2008320272B2 (en) 2014-01-23
CN101868475A (zh) 2010-10-20

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