JP2012077016A - 皮膚コラーゲン産生促進剤 - Google Patents
皮膚コラーゲン産生促進剤 Download PDFInfo
- Publication number
- JP2012077016A JP2012077016A JP2010222097A JP2010222097A JP2012077016A JP 2012077016 A JP2012077016 A JP 2012077016A JP 2010222097 A JP2010222097 A JP 2010222097A JP 2010222097 A JP2010222097 A JP 2010222097A JP 2012077016 A JP2012077016 A JP 2012077016A
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- JP
- Japan
- Prior art keywords
- milk protein
- protein fraction
- skin collagen
- collagen production
- milk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
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Abstract
皮膚の乾燥感や肌荒れ、シワやタルミを防止でき、しかも安全性の点でも問題のない食品素材としても使用可能な皮膚コラーゲンの生合成を促進する新たな皮膚コラーゲン産生促進剤を提供することを課題とする。また、本発明は、皮膚コラーゲン産生促進剤を配合した飲食品又は化粧料を提供することを課題とする。
【解決手段】
次の(a)から(c)の特性を有する乳タンパク質画分を有効成分とする皮膚コラーゲン産生促進剤。
(a)乳由来であること。
(b)ソディウムドデシルサルフェート−ポリアクリルアミドゲル(SDS-PAGE)電気泳動で、分子量12,000から16,000ダルトンの範囲のタンパク質を含有する画分であること。
(c)構成アミノ酸組成中に塩基性アミノ酸を18から20重量%含有し、かつ、塩基性アミノ酸/酸性アミノ酸比が0.7から0.9の範囲であること。
【選択図】なし
Description
(1)次の(a)から(c)の特性を有する乳タンパク質画分を有効成分とする皮膚コラーゲン産生促進剤。
(a)乳由来であること。
(b)ソディウムドデシルサルフェート−ポリアクリルアミドゲル(SDS-PAGE)電気泳動で、分子量12,000から16,000ダルトンの範囲のタンパク質を含有する画分であること。
(c)構成アミノ酸組成中に塩基性アミノ酸を18から20重量%含有し、かつ、塩基性アミノ酸/酸性アミノ酸比が0.7から0.9の範囲であること。
(2)前記(a)から(c)の特性を有する乳タンパク質画分の分解物を有効成分とする皮膚コラーゲン産生促進剤。
(3)(1)又は(2)に記載の乳タンパク質画分又は乳タンパク質画分の分解物を配合した皮膚コラーゲン産生促進用飲食品。
(4)(1)又は(2)に記載の乳タンパク質画分又は乳タンパク質画分の分解物を配合した皮膚コラーゲン産生促進用化粧料。
(5)次の(a)から(c)の特性を有する乳タンパク質画分を、一日当たり10μg以上経口摂取するか、又は0.001〜2重量%になるよう塗布することによる皮膚コラーゲンの産生促進方法。
(a)乳由来であること。
(b)ソディウムドデシルサルフェート−ポリアクリルアミドゲル(SDS-PAGE)電気泳動で、分子量12,000から16,000ダルトンの範囲のタンパク質を含有する画分であること。
(c)構成アミノ酸組成中に塩基性アミノ酸を18から20重量%含有し、かつ、塩基性アミノ酸/酸性アミノ酸比が0.7から0.9の範囲であること。
(6)前記(a)から(c)の特性を有する乳タンパク質画分の分解物を、一日当たり10μg以上経口摂取するか、又は0.001〜2重量%になるよう塗布することによる皮膚コラーゲンの産生促進方法。
下記の方法(特開2003−144095参照)により、皮膚コラーゲン産生促進作用が認められるの乳タンパク質画分を調製した。陽イオン交換樹脂のスルホン化キトパール(富士紡績製) 0.5リットルを充填した直径10cmのカラムを脱イオン水で充分洗浄した。このカラムに未殺菌脱脂乳 50リットルを流速100ml/minで通液した後、このカラムを脱イオン水で充分洗浄し、0.95M塩化ナトリウムを含む0.05Mリン酸緩衝液(pH7.0)2.5リットルを通液して樹脂に吸着したタンパク質を溶出した。そして、この溶出液を逆浸透(RO)膜処理により、脱塩し、濃縮した後、凍結乾燥して粉末状の乳タンパク質画分を得た。この操作を2回繰り返して104gのタンパク質画分を得た。このタンパク質画分の等電点は7.0〜8.5であって、このタンパク質画分に含まれる塩基性アミノ酸は17.8%であった。
参考例1で得られた乳タンパク質画分及び、実施例1で得られた乳タンパク質画分、実施例3で得られた乳タンパク質画分の分解物について、ラットを用いた動物実験によりコラーゲン産生促進作用を調べた。7週齢のWistar系雄ラットを、生理食塩水投与群(A群)、参考例1で得られた乳タンパク質画分をラット体重1kg当たり10μg投与する群(B群)、参考例1で得られた乳タンパク質画分をラット体重1kg当たり100μg投与する群(C群)、実施例1で得られた乳タンパク質画分をラット体重1kg当たり10μg投与する群(D群)、実施例1で得られた乳タンパク質画分をラット体重1kg当たり100μg投与する群(E群)、実施例3で得られた乳タンパク質画分の分解物をラット体重1kg当たり10μg投与する群(F群)、実施例3で得られた乳タンパク質画分の分解物をラット体重1kg当たり100μg投与する群(G群)の7試験群(n=6)に分け、それぞれを毎日1回ゾンデで投与して10週間飼育した。皮膚のコラーゲン量については、ラットの真皮をNimniらの方法(Arch. Biochem. Biophys., 292頁, 1967年 参照)に準じて処理した後、可溶性画分に含まれるヒドロキシプロリン量を測定した。ヒドロキシプロリンはコラーゲンのみに含まれる特殊なアミノ酸で、コラーゲンを構成する全アミノ酸の約10%を占めることからコラーゲン量の推定ができる(浅野隆司ら,Bio Industory,12頁, 2001年 参照)。その結果を表1に示す。
実施例2で得られた乳タンパク質画分(実施例品2)及び実施例4で得られた乳タンパク質画分の分解物(実施例品4)について、正常ヒト線維芽細胞株〔白人女性の皮膚より採取されたCCD45SK(ATCCRL 1506)〕を用いた実験により皮膚コラーゲン産生促進作用を調べた。10容量%ウシ胎児血清(以下FBSと略記)含有変法イーグル培地(MEM、10‐101、大日本製薬社製)を用いて、正常ヒト線維芽細胞株を4×104個/ウエル/0.4mlとなるように24ウエルプレートに播種して、5%炭酸ガス、飽和水蒸気下、37℃で24時間培養した後、0.6容量%FBS含有MEM培地に置換した。そして、実施例2で得られた乳タンパク質画分(実施例品2)及び実施例4で得られた乳タンパク質画分の分解物(実施例品4)を、各ウエルに0.1容量%となるように添加(n=6)して、24時間培養した後、β−アミノプロピオニトリルを50μg/ml、トリチウム−L−プロリンを1μCi/mlとなるように添加して、さらに24時間培養して培養液を得た。このようにして得られた培養液より、Websterらの方法(Analytical Biochemistry,220頁,1979年 参照)に従いコラーゲン画分を分画し、コラーゲン画分に取り込まれた放射能を測定した。なお、対照として、乳タンパク質画分及び乳タンパク質画分の分解物を添加しないで同様の試験を行った。その結果を表6に示す。
実施例8で得られた化粧水及び実施例9で得られたクリームを用いて、実使用テストを行った。比較品としては、乳タンパク質画分及び乳タンパク質画分の分解物を除いた以外は実施例8及び9と同じ配合のものを用いた。顔面のたるみや小ジワが認められる乾燥肌を有する成人女子20人を、それぞれ10人ずつ無作為に2群(A、B群)に、また、手に肌荒れが認められる女子20人を、それぞれ10人ずつ無作為に2群(C、D群)に分け、A群の顔面には本発明品の化粧水2gを、B群の顔面には比較品の化粧水2gを、C群の手指には本発明品のクリーム2gを、D群の手指には比較品のクリーム2gを、それぞれ1日2回通常の使用状態と同様に10日間塗布してもらった。その後、乾燥感、肌荒れ、シワ、たるみについて改善の程度を調査した。結果を表9に示す。
Claims (6)
- 次の(a)から(c)の特性を有する乳タンパク質画分を有効成分とする皮膚コラーゲン産生促進剤。
(a)乳由来であること。
(b)ソディウムドデシルサルフェート−ポリアクリルアミドゲル(SDS-PAGE)電気泳動で、分子量12,000から16,000ダルトンの範囲のタンパク質を含有する画分であること。
(c)構成アミノ酸組成中に塩基性アミノ酸を18から20重量%含有し、かつ、塩基性アミノ酸/酸性アミノ酸比が0.7から0.9の範囲であること。 - 前記(a)から(c)の特性を有する乳タンパク質画分の分解物を有効成分とする皮膚コラーゲン産生促進剤。
- 請求項1又は2に記載の乳タンパク質画分又は乳タンパク質画分の分解物を配合した皮膚コラーゲン産生促進用飲食品。
- 請求項1又は2に記載の乳タンパク質画分又は乳タンパク質画分の分解物を配合した皮膚コラーゲン産生促進用化粧料。
- 次の(a)から(c)の特性を有する乳タンパク質画分を、一日当たり10μg以上経口摂取するか、又は0.001〜2重量%になるよう塗布するによる皮膚コラーゲンの産生促進方法。
(a)乳由来であること。
(b)ソディウムドデシルサルフェート−ポリアクリルアミドゲル(SDS-PAGE)電気泳動で、分子量12,000から16,000ダルトンの範囲のタンパク質を含有する画分であること。
(c)構成アミノ酸組成中に塩基性アミノ酸を18から20重量%含有し、かつ、塩基性アミノ酸/酸性アミノ酸比が0.7から0.9の範囲であること。 - 前記(a)から(c)の特性を有する乳タンパク質画分の分解物を、一日当たり10μg以上経口摂取するか、又は0.001〜2重量%になるよう塗布することによる皮膚コラーゲンの産生促進方法。
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