WO2009054434A1 - Ｎｐｙ ｙ５受容体拮抗作用を有するアミン誘導体およびその用途 - Google Patents

Ｎｐｙ ｙ５受容体拮抗作用を有するアミン誘導体およびその用途 Download PDF

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Publication number
WO2009054434A1
WO2009054434A1 PCT/JP2008/069188 JP2008069188W WO2009054434A1 WO 2009054434 A1 WO2009054434 A1 WO 2009054434A1 JP 2008069188 W JP2008069188 W JP 2008069188W WO 2009054434 A1 WO2009054434 A1 WO 2009054434A1
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WIPO (PCT)
Prior art keywords
lower alkyl
npy
receptor antagonist
optionally substituted
amine derivative
Prior art date
Application number
PCT/JP2008/069188
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English (en)
French (fr)
Inventor
Takayuki Okuno
Naoki Kouyama
Masahiro Sakagami
Original Assignee
Shionogi & Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40579536&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009054434(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to AU2008314974A priority Critical patent/AU2008314974B2/en
Priority to CA2703797A priority patent/CA2703797A1/en
Priority to NZ584816A priority patent/NZ584816A/en
Priority to EP08841625.0A priority patent/EP2221051B1/en
Priority to ES08841625.0T priority patent/ES2445445T3/es
Application filed by Shionogi & Co., Ltd. filed Critical Shionogi & Co., Ltd.
Priority to JP2009513496A priority patent/JP4375683B2/ja
Priority to BRPI0818216A priority patent/BRPI0818216A2/pt
Priority to CN2008801133944A priority patent/CN101835471B/zh
Priority to MX2010003950A priority patent/MX2010003950A/es
Publication of WO2009054434A1 publication Critical patent/WO2009054434A1/ja
Priority to ZA2010/01954A priority patent/ZA201001954B/en
Priority to US12/767,641 priority patent/US8299265B2/en

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    • C07—ORGANIC CHEMISTRY
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
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Abstract

　式（Ｉ）： [Ｒ１は置換基を有していてもよい低級アルキルであり、 Ｙは－Ｓ(Ｏ)ｎ－（ｎは１または２である）または－ＣＯ－であり、 Ｒ２は水素または低級アルキルであり、 Ｒ７は水素または低級アルキルであり、 Ｘは低級アルキレン、低級アルケニレン、アリーレンまたはシクロアルキレン等であり、 Ｚは低級アルキル、置換基を有していてもよい炭化水素環式基または置換基を有していてもよいヘテロ環式基等である］ である化合物、それらの製薬上許容される塩またはそれらの溶媒和物を含有する食欲抑制剤または抗肥満薬。
PCT/JP2008/069188 2007-10-25 2008-10-23 Ｎｐｙ ｙ５受容体拮抗作用を有するアミン誘導体およびその用途 WO2009054434A1 (ja)

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MX2010003950A MX2010003950A (es) 2007-10-25 2008-10-23 Derivado de amina que tiene actividad antagonista del receptor y5 de neuropeptido y (npy) y uso del mismo.
CA2703797A CA2703797A1 (en) 2007-10-25 2008-10-23 Amine derivative having npy y5 receptor antagonist activity and use thereof
NZ584816A NZ584816A (en) 2007-10-25 2008-10-23 Cyclohexyl-substituted sulfonamides having npy y5 receptor antagonist activity and use thereof
EP08841625.0A EP2221051B1 (en) 2007-10-25 2008-10-23 Amine derivative having npy y5 receptor antagonist activity and use thereof
ES08841625.0T ES2445445T3 (es) 2007-10-25 2008-10-23 Derivado amínico con actividad antagonista del receptor NPY-Y5 y su uso
AU2008314974A AU2008314974B2 (en) 2007-10-25 2008-10-23 Amine derivative having NPY Y5 receptor antagonist activity and use thereof
JP2009513496A JP4375683B2 (ja) 2007-10-25 2008-10-23 Ｎｐｙｙ５受容体拮抗作用を有するアミン誘導体およびその用途
BRPI0818216A BRPI0818216A2 (pt) 2007-10-25 2008-10-23 derivado de amina tendo atividade antagonista do receptor npy y5 e uso do mesmo
CN2008801133944A CN101835471B (zh) 2007-10-25 2008-10-23 具有npy y5受体拮抗活性的胺衍生物
ZA2010/01954A ZA201001954B (en) 2007-10-25 2010-03-18 Amine derivative having npy y5 receptor antagonist activity and use thereof
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NZ584816A (en) 2012-04-27
ZA201001954B (en) 2011-05-25
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US8299265B2 (en) 2012-10-30
EP2221051A1 (en) 2010-08-25
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SA08290668B1 (ar) 2012-02-12
ES2445445T3 (es) 2014-03-03
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CN101835471A (zh) 2010-09-15
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