WO2008136273A1 - ビリルビン測定方法及びビリルビン測定に用いる分析用具 - Google Patents

ビリルビン測定方法及びビリルビン測定に用いる分析用具 Download PDF

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Publication number
WO2008136273A1
WO2008136273A1 PCT/JP2008/057475 JP2008057475W WO2008136273A1 WO 2008136273 A1 WO2008136273 A1 WO 2008136273A1 JP 2008057475 W JP2008057475 W JP 2008057475W WO 2008136273 A1 WO2008136273 A1 WO 2008136273A1
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WIPO (PCT)
Prior art keywords
bilirubin
determination
bilirubin determination
analytical instrument
instrument used
Prior art date
Application number
PCT/JP2008/057475
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English (en)
French (fr)
Inventor
Toshio Takama
Original Assignee
Arkray, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arkray, Inc. filed Critical Arkray, Inc.
Priority to JP2008531474A priority Critical patent/JP4785926B2/ja
Priority to US12/526,214 priority patent/US9442122B2/en
Priority to EP08740545A priority patent/EP2108703B1/en
Priority to CN2008800066872A priority patent/CN101622359B/zh
Publication of WO2008136273A1 publication Critical patent/WO2008136273A1/ja

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/728—Bilirubin; including biliverdin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/521—Single-layer analytical elements
    • G01N33/523—Single-layer analytical elements the element being adapted for a specific analyte
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0325—Cells for testing reactions, e.g. containing reagents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7773—Reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7783—Transmission, loss
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

ビリルビンオキシダーゼの反応を促進可能な乾燥試薬を用いるビリルビン測定方法及び該ビリルビン測定方法に用いる分析用具の提供。 ビリルビン測定方法において、生体試料とビリルビンオキシダーゼ含有乾燥試薬との混合の後に、前記混合物と界面活性剤含有乾燥試薬とを混合することを特徴とする。また、ビリルビン測定に用いる分析用具（１）において、試料供給部（１１）、前記流路（１２，１３，１４）、検出部（１５）のいずれかに、ビリルビンオキシダーゼ及び界面活性剤が、前記ビリルビンオキシダーゼが前記界面活性剤より前記試料供給部（１１）に近い位置となるように配置されていることを特徴とする。
PCT/JP2008/057475 2007-04-27 2008-04-17 ビリルビン測定方法及びビリルビン測定に用いる分析用具 WO2008136273A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2008531474A JP4785926B2 (ja) 2007-04-27 2008-04-17 ビリルビン測定方法及びビリルビン測定に用いる分析用具
US12/526,214 US9442122B2 (en) 2007-04-27 2008-04-17 Method for assaying bilirubin and assay instrument used in bilirubin assay
EP08740545A EP2108703B1 (en) 2007-04-27 2008-04-17 Method for bilirubin determination and analytical instrument used for bilirubin determination
CN2008800066872A CN101622359B (zh) 2007-04-27 2008-04-17 胆红素测定方法以及用于胆红素测定的分析用具

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-119480 2007-04-27
JP2007119480 2007-04-27

Publications (1)

Publication Number Publication Date
WO2008136273A1 true WO2008136273A1 (ja) 2008-11-13

Family

ID=39943389

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/057475 WO2008136273A1 (ja) 2007-04-27 2008-04-17 ビリルビン測定方法及びビリルビン測定に用いる分析用具

Country Status (5)

Country Link
US (1) US9442122B2 (ja)
EP (1) EP2108703B1 (ja)
JP (1) JP4785926B2 (ja)
CN (1) CN101622359B (ja)
WO (1) WO2008136273A1 (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015021906A (ja) * 2013-07-22 2015-02-02 東亜ディーケーケー株式会社 測定方法、測定用のカートリッジ及び測定装置
CN106404686B (zh) * 2016-08-27 2019-03-29 山东博科生物产业有限公司 一种抗肝素的血清总胆红素(钒酸盐氧化法)检测试剂盒
CN106841078A (zh) * 2017-03-31 2017-06-13 福建师范大学 一种水溶液中胆红素浓度的定量测定方法
JP7200142B2 (ja) 2017-07-05 2023-01-06 ミダイアグノスティクス・エヌブイ 流体内で試薬を溶解するための毛細管駆動のマイクロ流体システムにおける装置

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005637A2 (en) 1978-05-19 1979-11-28 EASTMAN KODAK COMPANY (a New Jersey corporation) Bilirubin-specific fungal enzyme compositions, their use in dry test elements and assay methods and methods for their extraction
JPS59130198A (ja) 1983-01-11 1984-07-26 Nippon Shoji Kk ビリルビン測定試薬および測定法
WO1986000933A1 (en) 1984-07-28 1986-02-13 Beckman Instruments, Inc. Novel reagent and method employing same
JPS62105047A (ja) * 1985-10-31 1987-05-15 Amano Pharmaceut Co Ltd ビリルビンの分別測定法
JPS62282598A (ja) 1987-04-24 1987-12-08 Amano Pharmaceut Co Ltd 総ビリルビンの定量法及び定量用試薬組成物
JPS6352060A (ja) * 1986-04-16 1988-03-05 Kyowa Medetsukusu Kk 間接ビリルビンの定量法及び定量用キツト
US5104794A (en) * 1989-03-13 1992-04-14 Unitika Ltd. Quantitative determination of bilirubin and a reagent therefor
JPH11123099A (ja) * 1998-08-13 1999-05-11 Unitika Ltd 非抱合型ビリルビンの測定方法および測定用試薬
EP1557660A1 (en) 2002-10-28 2005-07-27 ARKRAY, Inc. Method of correction at sample analysis, analyzer and analytical equipment
JP2006034178A (ja) 2004-07-28 2006-02-09 Eiken Chem Co Ltd 総ビリルビンの測定法およびそれに用いる試薬

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3239236A1 (de) * 1982-02-18 1983-09-01 Amano Pharma Co Ltd Verfahren zur quantitativen bestimmung von physiologischen komponenten in biologischen fluessigkeiten oder gasen
JPS59125899A (ja) * 1982-12-29 1984-07-20 Nippon Shoji Kk 酵素法による直接ビリルビン測定用試薬および測定法
JPS6352064A (ja) * 1986-08-22 1988-03-05 Nippon Tectron Co Ltd 試薬ピペツト装置
JP2578430B2 (ja) * 1987-06-10 1997-02-05 旭化成工業株式会社 新規なビリルビン．オキシダーゼおよびその製造法
US7615337B2 (en) 2004-08-27 2009-11-10 Intel Corporation Photoactive resist capping layer
CN1687786A (zh) * 2005-04-29 2005-10-26 张抗 全液体型酶法结合胆红素测定试剂盒
US7749766B2 (en) * 2007-01-12 2010-07-06 Nova Biomedical Corporation Bilirubin sensor

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005637A2 (en) 1978-05-19 1979-11-28 EASTMAN KODAK COMPANY (a New Jersey corporation) Bilirubin-specific fungal enzyme compositions, their use in dry test elements and assay methods and methods for their extraction
JPS59130198A (ja) 1983-01-11 1984-07-26 Nippon Shoji Kk ビリルビン測定試薬および測定法
WO1986000933A1 (en) 1984-07-28 1986-02-13 Beckman Instruments, Inc. Novel reagent and method employing same
JPS62105047A (ja) * 1985-10-31 1987-05-15 Amano Pharmaceut Co Ltd ビリルビンの分別測定法
JPS6352060A (ja) * 1986-04-16 1988-03-05 Kyowa Medetsukusu Kk 間接ビリルビンの定量法及び定量用キツト
JPS62282598A (ja) 1987-04-24 1987-12-08 Amano Pharmaceut Co Ltd 総ビリルビンの定量法及び定量用試薬組成物
US5104794A (en) * 1989-03-13 1992-04-14 Unitika Ltd. Quantitative determination of bilirubin and a reagent therefor
JPH11123099A (ja) * 1998-08-13 1999-05-11 Unitika Ltd 非抱合型ビリルビンの測定方法および測定用試薬
EP1557660A1 (en) 2002-10-28 2005-07-27 ARKRAY, Inc. Method of correction at sample analysis, analyzer and analytical equipment
JP2006034178A (ja) 2004-07-28 2006-02-09 Eiken Chem Co Ltd 総ビリルビンの測定法およびそれに用いる試薬

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DOUMAS B.T. ET AL.: "Determination of the sum of bilirubin sugar conjugates in plasma by bilirubin oxidase", CLIN. CHEM., vol. 45, no. 8, August 1999 (1999-08-01), pages 1255 - 1260, XP008111644 *
GROHMANN K. ET AL.: "Bilirubin measurement for neonates: comparison of 9 frequently used methods", PEDIATRICS, vol. 117, no. 4, April 2006 (2006-04-01), pages 1174 - 1183, XP008112147 *
See also references of EP2108703A4 *

Also Published As

Publication number Publication date
EP2108703B1 (en) 2012-08-08
JPWO2008136273A1 (ja) 2010-07-29
JP4785926B2 (ja) 2011-10-05
US9442122B2 (en) 2016-09-13
CN101622359A (zh) 2010-01-06
CN101622359B (zh) 2012-10-31
US20100323382A1 (en) 2010-12-23
EP2108703A4 (en) 2010-02-24
EP2108703A1 (en) 2009-10-14

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