WO2007144983A1 - 歯質硬度維持剤 - Google Patents
歯質硬度維持剤 Download PDFInfo
- Publication number
- WO2007144983A1 WO2007144983A1 PCT/JP2007/000626 JP2007000626W WO2007144983A1 WO 2007144983 A1 WO2007144983 A1 WO 2007144983A1 JP 2007000626 W JP2007000626 W JP 2007000626W WO 2007144983 A1 WO2007144983 A1 WO 2007144983A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lactoferrin
- iron
- hardness
- maintaining
- dental
- Prior art date
Links
- 229940078795 lactoferrin Drugs 0.000 claims abstract description 67
- 102000010445 Lactoferrin Human genes 0.000 claims abstract description 42
- 108010063045 Lactoferrin Proteins 0.000 claims abstract description 42
- 235000021242 lactoferrin Nutrition 0.000 claims abstract description 42
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims abstract description 41
- 239000004480 active ingredient Substances 0.000 claims abstract description 9
- 238000012423 maintenance Methods 0.000 claims description 6
- 241000610375 Sparisoma viride Species 0.000 claims 1
- 230000035622 drinking Effects 0.000 claims 1
- 208000002925 dental caries Diseases 0.000 abstract description 14
- 210000003298 dental enamel Anatomy 0.000 abstract description 14
- 235000013305 food Nutrition 0.000 abstract description 10
- 238000005115 demineralization Methods 0.000 abstract description 6
- 230000002328 demineralizing effect Effects 0.000 abstract description 6
- 235000013361 beverage Nutrition 0.000 abstract 1
- 230000037406 food intake Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 31
- 229910052742 iron Inorganic materials 0.000 description 17
- 239000000243 solution Substances 0.000 description 14
- 230000000694 effects Effects 0.000 description 9
- 235000013336 milk Nutrition 0.000 description 9
- 210000004080 milk Anatomy 0.000 description 9
- 239000008267 milk Substances 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 8
- 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 210000000214 mouth Anatomy 0.000 description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- -1 iron ion Chemical class 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000001766 physiological effect Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 229920001503 Glucan Polymers 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 239000005862 Whey Substances 0.000 description 3
- 102000007544 Whey Proteins Human genes 0.000 description 3
- 108010046377 Whey Proteins Proteins 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 210000004268 dentin Anatomy 0.000 description 3
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- 239000005720 sucrose Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 2
- 102000030902 Galactosyltransferase Human genes 0.000 description 2
- 108060003306 Galactosyltransferase Proteins 0.000 description 2
- 102000008133 Iron-Binding Proteins Human genes 0.000 description 2
- 108010035210 Iron-Binding Proteins Proteins 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 241000194019 Streptococcus mutans Species 0.000 description 2
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- 239000003814 drug Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
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- 239000002324 mouth wash Substances 0.000 description 2
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- 239000010703 silicon Substances 0.000 description 2
- 235000020183 skimmed milk Nutrition 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- SPFMQWBKVUQXJV-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;hydrate Chemical compound O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O SPFMQWBKVUQXJV-BTVCFUMJSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 229940126062 Compound A Drugs 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000193987 Streptococcus sobrinus Species 0.000 description 1
- 241000310231 Streptococcus sobrinus DSM 20742 = ATCC 33478 Species 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 235000010724 Wisteria floribunda Nutrition 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
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- 239000013543 active substance Substances 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
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- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940077731 carbohydrate nutrients Drugs 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 235000020247 cow milk Nutrition 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 239000005548 dental material Substances 0.000 description 1
- 238000011033 desalting Methods 0.000 description 1
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- 230000000206 effect on caries Effects 0.000 description 1
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- 230000006870 function Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000020251 goat milk Nutrition 0.000 description 1
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- 235000020981 healthy eating habits Nutrition 0.000 description 1
- 235000020256 human milk Nutrition 0.000 description 1
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- 230000002401 inhibitory effect Effects 0.000 description 1
- 150000002505 iron Chemical class 0.000 description 1
- RUTXIHLAWFEWGM-UHFFFAOYSA-H iron(3+) sulfate Chemical compound [Fe+3].[Fe+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O RUTXIHLAWFEWGM-UHFFFAOYSA-H 0.000 description 1
- 229910000360 iron(III) sulfate Inorganic materials 0.000 description 1
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- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- CTYRPMDGLDAWRQ-UHFFFAOYSA-N phenyl hydrogen sulfate Chemical compound OS(=O)(=O)OC1=CC=CC=C1 CTYRPMDGLDAWRQ-UHFFFAOYSA-N 0.000 description 1
- 230000007505 plaque formation Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
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- 238000001223 reverse osmosis Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 235000020254 sheep milk Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
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- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the present invention relates to a dental hardness maintaining agent containing lactoferrin and / or iron-lactoferrin, which are milk components, as an active ingredient, or to a food and drink for maintaining dental hardness containing lactoferrin and / or iron-lactoferrin.
- the dental hardness maintaining agent and the dental hardness maintaining food and drink of the present invention prevent the decrease in dental hardness by suppressing the demineralization of enamel, and prevent healthy teeth mainly in the elderly. It is possible to obtain the maintenance effect of the mastication function for maintenance and accompanying healthy eating habits.
- Dental caries is a phenomenon in which hard tissues of teeth (enamel and dentin) dissolve (demineralize), and it is caused by three factors: microorganisms, teeth, and food. It is caused by a state of high dental caries, a state of high sensitivity to dental caries, and a state of high caries induction of eating habits.
- the mechanism of caries development is that galactosyltransferase (GTase) is first produced by Streptococcus mutans, and glucan, an insoluble and sticky polysaccharide, is synthesized using sucrose as a substrate.
- GTase galactosyltransferase
- the synthesized glucan adheres to the tooth surface together with carious fungi to form plaques, and lactic acid bacteria (LactGOGGUs l act ics subsp. I act is) produce lactic acid in the plaques to decalcify enamel. Because of that.
- caries development involves many factors such as plaque formation, oral bacteria, carbohydrates, and dental materials. Currently, there are many ways to prevent dental caries that take these factors into account. Has been developed.
- Lactoferrin is an iron-binding glycoprotein with a molecular weight of about 80 kDa that is contained in the secretion of mammals such as milk, tears, saliva, bile, and semen, or in the secondary granules of neutrophils.
- X-ray analysis reveals a higher-order structure consisting of two lobes, and in the presence of hydrogen carbonate ion or carbonate ion at each iron binding site, 3 A three-dimensional structure in which a valent iron ion is chelated is also reported.
- lactoferrin As the recognition of lactoferrin as a physiologically active substance increases, its application to food, feed, pharmaceuticals, etc. is also being realized. Lactoferrin is known to be effective in preventing dental caries due to its pathogen-inhibiting action (see, for example, Patent Document 1). However, this is only an action to prevent the pathogenic bacteria from adhering to the teeth, and the effect on caries after the pathogenic bacteria have once adhered has not been clarified at all.
- iron-lactoferrin is designed to stably hold at least 3 atoms of iron per molecule of lactoferrin by performing a specific treatment on lactoferrin.
- a lactoferrin powder that stably retains iron obtained by adding iron salt to a lactoferrin solution and increasing the pH of the solution by adding alkali see, for example, Patent Document 2
- bicarbonate ion in lactoferrin amino group A heat-resistant lactoferrin-iron-iron conjugate with iron bound thereto via for example, see Patent Document 3
- An iron-lactoferrin complex (see, for example, Patent Document 4) obtained in this manner is known.
- These iron-lactoferrin have been shown to have physiological activities such as anti-inflammatory and bone strengthening effects, but their effects on caries have not been verified so far.
- Patent Document 1 Japanese Patent Application Laid-Open No. 3-222013
- Patent Document 2 Japanese Patent Application Laid-Open No. 7-1 7 8 2 5
- Patent Document 3 Japanese Patent Laid-Open No. 6-2 3 9 900
- Patent Document 4 Japanese Patent Laid-Open No. 7-3 0 4 7 9 8
- An object of the present invention is to provide a dental hardness maintaining agent containing lactoferrin and / or iron-lactoferrin as an active ingredient, and a food and drink for maintaining dental hardness. By directly touching the teeth in the mouth, they can suppress the decrease in hardness (demineralization) of enamel and effectively prevent caries, that is, caries.
- the present inventors focused on lactoferrin and iron-lactoferrin, which have various physiological activities, in particular, high physiological activity on bones.
- the inventors have found an effect of suppressing the hardness reduction of enamel and have completed the present invention.
- the present inventors have completed a dental hardness maintenance agent containing lactoferrin and iron-lactoferrin as active ingredients, which have a high preventive effect on caries, utilizing the effect of lactoferrin and iron-lactoferrin on reducing enamel hardness.
- lactoferrin that can be used in the present invention is derived from milk of mammals such as cow's milk, human milk, goat milk, and sheep milk. Lactoferrin is lysine
- This basic protein contains a lot of basic amino acids such as arginine, and is sometimes collectively called a basic protein.
- This basic protein can be obtained by purifying milk raw materials such as skim milk and whey using a cation exchange resin.
- the ability to separate and purify lactoferrin from ⁇ L, and to add the necessary amount In particular, use of a basic protein fraction containing lactoferrin obtained from skim milk or whey of milk. You can also.
- the cation exchanger As a method of obtaining the basic protein fraction containing lactoferrin, after basing L or milk-derived material on the cation exchanger to adsorb the basic protein, the cation exchanger A method of obtaining adsorbed basic protein by elution with an eluent exceeding pH 5 and ion strength exceeding 0.5 (Publication of Japanese Patent Laid-Open No. 5-20208), Method using alginate gel (Japanese Patent Laid-Open No. 6 1-246 1 9 8), a method of obtaining from whey using inorganic porous particles (Japanese Patent Laid-Open No.
- the iron-lactoferrin that can be used in the present invention is a state in which iron and lactoferrin are bound to each other, and the iron and lactoferrin are bound to each other, or iron is introduced through another substance. And lactoferrin are combined, and so-called iron is not present in the ion state.
- Examples include the above-mentioned “iron-lactoferrin conjugate” and “iron-lactoferrin complex” obtained by adding a solution containing carbonic acid and / or bicarbonate to a lactoferrin and a solution containing iron. These iron monolactofurin can be used as an active ingredient of the present invention.
- iron-lactoferrins have heat resistance, there is no problem even if they are heat-treated when they are added and processed in formulations and foods and drinks. Moreover, these iron-lactofurrins have the characteristic that there is no metal taste or the like if the iron converges, so there is no problem in flavor.
- the tooth hardness maintaining agent and the food and drink for maintaining tooth hardness of the present invention can suppress the demineralization of tooth enamel that occurs after bacteria adherence by using or ingesting them. Therefore, it is effective for maintaining dental hardness and preventing dental caries.
- the dental hardness maintaining agent of the present invention comprises lactoferrin and / or iron-lactoferrin as active ingredients, for example, toothpaste, mouthwash, mouth odor inhibitor, mouthwash, candy, gum, It can be used in combination with pharmaceuticals and foods and drinks in the form of lozenges.
- the dosage form and dosage should be about 1 to 5 O mg per adult per day divided into several portions and contacted with the tooth surface.
- lactoferrin and iron-lactoferrin which are the active ingredients of the present invention, have been applied to various agents and foods and drinks due to their excellent physiological activity, and it can be said that there is no problem with their safety.
- a solution containing 10 mol of lactoferrin thus obtained and 1.2 mol of sodium bicarbonate was prepared as solution A.
- After adding solution B to solution A desalting and concentrating with an ultrafiltration membrane with a molecular weight of 5,000 cut, diluting with simulated buffer (PH8.9) to an iron concentration of 94 mg / 100 ml, Iron-lactoferrin was obtained.
- the iron-lactoferrin thus obtained contained 0.9 g of reductoferrin per 100 ml of solution and 94 mg of iron.
- Example 2 Using the lactoferrin produced in Example 1 and iron-lactoferrin, the dentine hardness maintaining action was verified using an artificial oral cavity device.
- This device consists of three artificial oral cavity parts, two pumps for liquid feeding, a thermostatic bath, three cooling stirrers, and a pH recorder.
- a silicon plug with five stainless steel tubes fixed from the top was attached and a silicon plug with a drain tube and a flat pH electrode fixed upside down was sealed from the bottom.
- Warm water to the water jacket of the artificial oral cavity Circulation maintained the inside of the device at 37 ° C.
- four sushi enamel tooth pieces (3.5 countries x 3.5 countries X 1.5 countries) were fixed on a Teflon holder using utility wax.
- HI medium containing 2.5% sucrose (1.0% on the electrode) and bacterial suspension were continuously added dropwise.
- PBS was added as a control, and various milk components were added dropwise as an experimental group.
- the dropping was continued for 15 to 18 hours while continuously recording the pH, and the dropping was terminated when the pH of the control dropped to around 4 with the formation of human plaque.
- Artificial biofilms formed on enamel teeth and pH electrodes were treated with 0.5N sodium hydroxide solution and centrifuged, and the turbidity of the precipitate was measured at 500 nm to determine the amount of cells.
- the supernatant was quantified by the phenol sulfate method to obtain the amount of water-insoluble glucan (WIG).
- the decalcification degree of enamel was evaluated from the change in Vicker's hardness ( ⁇ ) before and after the experiment.
- the ingredients shown in Table 1 were mixed to produce a cream and filled in a container to produce a dentifrice for preventing and improving periodontal disease.
- FIG. 1 shows the effects of lactoferrin and iron-lactofurin on the change in dental hardness in Test Example 1.
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Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2007259959A AU2007259959B2 (en) | 2006-06-15 | 2007-06-13 | Agent for maintaining the hardness of tooth structure |
CA2655352A CA2655352C (en) | 2006-06-15 | 2007-06-13 | Agent for maintaining the hardness of toothsubstances |
US12/304,799 US20090176693A1 (en) | 2006-06-15 | 2007-06-13 | Agent for maintaining the hardness of tooth structure |
EP07737280.3A EP2039342A4 (en) | 2006-06-15 | 2007-06-13 | MEANS FOR MAINTAINING THE HARDENING TISSUE STRUCTURE |
CN2007800223629A CN101472554B (zh) | 2006-06-15 | 2007-06-13 | 牙质硬度维持剂 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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JP2006165591A JP2007332072A (ja) | 2006-06-15 | 2006-06-15 | 歯質硬度維持剤 |
JP2006-165591 | 2006-06-15 |
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WO2007144983A1 true WO2007144983A1 (ja) | 2007-12-21 |
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PCT/JP2007/000626 WO2007144983A1 (ja) | 2006-06-15 | 2007-06-13 | 歯質硬度維持剤 |
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US (1) | US20090176693A1 (ja) |
EP (1) | EP2039342A4 (ja) |
JP (1) | JP2007332072A (ja) |
KR (1) | KR20090016730A (ja) |
CN (1) | CN101472554B (ja) |
AU (1) | AU2007259959B2 (ja) |
CA (1) | CA2655352C (ja) |
WO (1) | WO2007144983A1 (ja) |
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JP5973585B2 (ja) | 2011-11-08 | 2016-08-23 | コスウェル・エス・ペー・アーCoswell S.P.A. | ラクトフェリン機能化表面を有する生体模倣ヒドロキシアパタイト粒子を含有するデンタルケア製品 |
JP6256770B2 (ja) * | 2015-05-07 | 2018-01-10 | ジャパンモード株式会社 | 口腔ケア組成物、錠剤、顆粒状薬剤 |
JP6570112B2 (ja) * | 2015-06-18 | 2019-09-04 | ジャパンモード株式会社 | 医薬品の製造方法 |
CN110946772A (zh) * | 2019-12-27 | 2020-04-03 | 苏格格 | 一种预防牙病的牙膏及其制备方法 |
Citations (8)
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JPS61246198A (ja) | 1985-02-07 | 1986-11-01 | オレオフイナ・ソシエテ・アノニム | 蛋白の精製法 |
JPS63255300A (ja) | 1987-04-10 | 1988-10-21 | Snow Brand Milk Prod Co Ltd | 硫酸エステル化物を用いて乳からラクトフエリンを分離、精製する方法 |
JPS6486839A (en) | 1987-06-19 | 1989-03-31 | Entamonto Sa | Method for selectively extracting metal protein from whey |
JPH03220130A (ja) | 1990-01-25 | 1991-09-27 | Snow Brand Milk Prod Co Ltd | 病原菌付着阻止剤及びそれを含有する飲食品等 |
JPH05202098A (ja) | 1992-01-29 | 1993-08-10 | Snow Brand Milk Prod Co Ltd | 乳質原料から生理活性物質の製造法 |
JPH06239900A (ja) | 1993-02-16 | 1994-08-30 | Snow Brand Milk Prod Co Ltd | 耐熱性ラクトフェリン−鉄結合体及びその製造法 |
JPH0717825A (ja) | 1993-06-30 | 1995-01-20 | Nichiden Kagaku Kk | 化粧品基材 |
JPH07304798A (ja) | 1994-03-18 | 1995-11-21 | Snow Brand Milk Prod Co Ltd | 鉄−ラクトフェリン複合体及びその製造法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2832517B2 (ja) * | 1994-12-09 | 1998-12-09 | 雪印乳業株式会社 | 大腸菌付着阻止剤 |
JP3396009B2 (ja) * | 1995-10-17 | 2003-04-14 | 雪印乳業株式会社 | 低う蝕性栄養組成物 |
WO2002047612A2 (en) * | 2000-10-27 | 2002-06-20 | Mannatech, Inc. | Dietary supplement compositions |
EP1625877A3 (en) * | 2004-08-09 | 2006-03-08 | Friesland Brands B.V. | Functional milk fraction |
NZ540633A (en) * | 2005-06-09 | 2008-12-24 | Fonterra Co Operative Group | Preparing metal ion-lactoferrin comprising contacting a lactoferrin source with a lactoferrin-binding matrix, contacting the immobilised lactoferrin with a source of metal ions to produce metal ion-lactoferrin |
-
2006
- 2006-06-15 JP JP2006165591A patent/JP2007332072A/ja active Pending
-
2007
- 2007-06-13 CA CA2655352A patent/CA2655352C/en not_active Expired - Fee Related
- 2007-06-13 WO PCT/JP2007/000626 patent/WO2007144983A1/ja active Application Filing
- 2007-06-13 KR KR1020087031532A patent/KR20090016730A/ko not_active Application Discontinuation
- 2007-06-13 EP EP07737280.3A patent/EP2039342A4/en not_active Withdrawn
- 2007-06-13 AU AU2007259959A patent/AU2007259959B2/en not_active Ceased
- 2007-06-13 US US12/304,799 patent/US20090176693A1/en not_active Abandoned
- 2007-06-13 CN CN2007800223629A patent/CN101472554B/zh not_active Expired - Fee Related
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61246198A (ja) | 1985-02-07 | 1986-11-01 | オレオフイナ・ソシエテ・アノニム | 蛋白の精製法 |
JPS63255300A (ja) | 1987-04-10 | 1988-10-21 | Snow Brand Milk Prod Co Ltd | 硫酸エステル化物を用いて乳からラクトフエリンを分離、精製する方法 |
JPS6486839A (en) | 1987-06-19 | 1989-03-31 | Entamonto Sa | Method for selectively extracting metal protein from whey |
JPH03220130A (ja) | 1990-01-25 | 1991-09-27 | Snow Brand Milk Prod Co Ltd | 病原菌付着阻止剤及びそれを含有する飲食品等 |
JPH05202098A (ja) | 1992-01-29 | 1993-08-10 | Snow Brand Milk Prod Co Ltd | 乳質原料から生理活性物質の製造法 |
JPH06239900A (ja) | 1993-02-16 | 1994-08-30 | Snow Brand Milk Prod Co Ltd | 耐熱性ラクトフェリン−鉄結合体及びその製造法 |
JPH0717825A (ja) | 1993-06-30 | 1995-01-20 | Nichiden Kagaku Kk | 化粧品基材 |
JPH07304798A (ja) | 1994-03-18 | 1995-11-21 | Snow Brand Milk Prod Co Ltd | 鉄−ラクトフェリン複合体及びその製造法 |
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Publication number | Publication date |
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CN101472554B (zh) | 2011-06-22 |
CN101472554A (zh) | 2009-07-01 |
JP2007332072A (ja) | 2007-12-27 |
AU2007259959A1 (en) | 2007-12-21 |
EP2039342A4 (en) | 2014-02-26 |
CA2655352C (en) | 2014-05-06 |
KR20090016730A (ko) | 2009-02-17 |
US20090176693A1 (en) | 2009-07-09 |
CA2655352A1 (en) | 2007-12-21 |
AU2007259959B2 (en) | 2013-10-31 |
EP2039342A1 (en) | 2009-03-25 |
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