WO2004039347A1 - Composition dermoprotectrice liquide - Google Patents

Composition dermoprotectrice liquide Download PDF

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Publication number
WO2004039347A1
WO2004039347A1 PCT/JP2003/013545 JP0313545W WO2004039347A1 WO 2004039347 A1 WO2004039347 A1 WO 2004039347A1 JP 0313545 W JP0313545 W JP 0313545W WO 2004039347 A1 WO2004039347 A1 WO 2004039347A1
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WO
WIPO (PCT)
Prior art keywords
skin
component
liquid
weight
composition according
Prior art date
Application number
PCT/JP2003/013545
Other languages
English (en)
Japanese (ja)
Inventor
Masaya Nishio
Original Assignee
Kao Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kao Corporation filed Critical Kao Corporation
Priority to AU2003275610A priority Critical patent/AU2003275610A1/en
Priority to US10/533,235 priority patent/US20060039885A1/en
Priority to EP03758814A priority patent/EP1559415A4/fr
Priority to JP2004548031A priority patent/JP4354914B2/ja
Publication of WO2004039347A1 publication Critical patent/WO2004039347A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/046—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A61K8/585—Organosilicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A61K8/894—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/75—Anti-irritant

Definitions

  • the present invention relates to a liquid skin protective agent composition. More specifically, the present invention protects the skin from substances that adversely affect the skin when it comes into contact with the skin, such as environmental chemicals, chemicals in water, allergens, urine, stool, sweat, blood, body fluids, and wound exudates.
  • the present invention relates to a liquid skin protectant composition which is used for diaper use such as for babies and incontinent persons, for the skin around the stoma, and around the wound with exudate.
  • the surface of the skin is covered by the stratum corneum, and ceramide / lipids, NMF, etc. contained in the stratum corneum act as a barrier function against foreign substances from the outside and have a very high permeation blocking effect.
  • the skin inside the diaper of infants and care recipients using the diaper, the skin around the stoma, and the skin around the wound with exudate such as pressure ulcer, sweat, urine, stool, wound It often comes into contact with liquids that mainly contain water, such as exudates, for a long time, and contains water, enzymes such as lipase, protease, urease, bacteria, and ammonia generated by them.
  • a skin protective agent using an alkylsiloxane-containing polymer for example, Japanese Patent Application Laid-Open No. H4-1501076), a skin protective agent using an organic silicone resin (for example, JP-A-61-58080) No. 8), a skin protective agent using a silicone / acrylic copolymer (for example, Japanese Patent Application Laid-Open No. Hei 2-262125) has high skin adhesion but high skin irritation.
  • Use of organic solvents is required, and use on sensitive skin is not preferred.
  • sweating under conditions in which sweating is likely to occur, it will immediately peel off.
  • adhesion to the skin is very strong, but it cannot be achieved without the use of a highly irritating release agent.
  • a sufficient skin-protecting effect was a problem that can not be obtained.
  • an effervescent skin protective agent for example, Japanese Patent Application Laid-Open No. 2002-145755
  • effervescent skin protective agent requires emulsification of an active ingredient and contains a large amount of an emulsifier.
  • a substance containing a large amount of water, such as urine exudate adheres to the skin, it re-emulsifies, easily peels off the skin, and cannot form a continuous film having a long-lasting effect.
  • a skin cosmetic containing a non-hydrolyzable block copolymer having a linear polysiloxane-polyoxyalkylene block as a repeating unit JP-A-4-234307) has also been reported.
  • this skin cosmetic contains a large amount of water, it has a stimulating sensation such as giving a strong cooling sensation at the time of application.In addition, it does not feel good and its viscosity is high, so it can be applied evenly over a wide area. There was a problem of wanting.
  • a skin protective agent containing a coating agent, a hydrophobic powder, and a volatile oil component Japanese Patent Application Laid-Open No. Hei 7-224258, has been reported, but in this document, a solvent for the coating component is used. A large amount of ethanol is used. If such a skin protectant is used on sensitive areas such as rough skin, ethanol will bleed and hurt, so it will be very hard to use. High skin protection, long lasting effect, low irritation, easy to apply, There has been no skin protective agent that satisfies all the conditions of good feel after cloth.
  • An object of the present invention is to provide a liquid skin protectant composition that protects the skin from environmental irritants such as chemical substances, body fluids, excretions, and exudates, has low irritation, and is easy to apply immediately after application. To provide. Disclosure of the invention
  • the present inventors have made various studies and found that a combination of a block copolymer having a specific HLB having a linear polysiloxane-polyoxyalkylene block as a constitutional unit and an oil agent, and further reducing the water content, It has been found that a skin protective agent that gives a good feel, a low irritancy and easy application can be obtained.
  • the present invention provides a liquid skin protectant composition containing the following components (A) and (B) and having a water content of 10% by weight or less:
  • One or more oil agents selected from (B) mineral oils, vegetable oils, animal oils, synthetic oils, and organopolysiloxanes other than the (A) component.
  • the structure of the polyoxyalkylene block portion of the block copolymer comprising the linear polysiloxane-polyoxyalkylene block as the component (A) of the present invention as a constituent unit includes polyoxyethylene, polyoxypropylene, and polyoxyethylene. Ethylenepolyoxypropylene is mentioned. Among them, polyoxyethylenepolyoxypropylene is more preferable when a water-repellent oil agent or a volatile oil agent is blended, since it is a homogeneously dissolved system and has excellent low-temperature stability.
  • a linear polysiloxane-polyoxyalkylene block polymer described in Japanese Patent Application Laid-Open No. 432,073 can be used. That is, the block copolymer of the component (A) has the general formula (1):
  • R represents a monovalent hydrocarbon group containing no aliphatic unsaturation
  • A represents an alkylene group having 2 to 4 carbon atoms
  • b represents a number of 4 to 100 (preferably 10 to 100)
  • c is a number from 2 to 40 (preferably a number from 2 to 20)
  • a is a number from 4 to 100 (Preferably a number of 5 to 40)
  • Y represents a divalent organic group bonded to the adjacent silicon atom by a carbon-silicon bond and to the polyoxyalkylene block by an oxygen atom.
  • a siloxane-polyoxyalkylene block polymer can be used.
  • R ′′ represents a monovalent hydrocarbon group containing no aliphatic unsaturation, and a is a number of 4 to 100 (preferably a number of 5 to 40)].
  • CH 2 CCH 20 (AO)
  • b CH 2 C CH 2 (B)
  • R represents a monovalent hydrocarbon group
  • A represents an alkylene group having 2 to 4 carbon atoms
  • b represents a number of 4 to 100 (preferably a number of 10 to 90) Wherein b AOs may be the same or different.
  • a is a number of 4 to 100 (preferably a number of 5 to 40), and b is 4 to 10 0 (preferably a number from 10 to 90); b AOs may be the same or different; c is a number from 2 to 40 (preferably a number from 2 to 20); , Represents a monovalent hydrocarbon group, and R , represents a monovalent hydrocarbon group.
  • R, R, R, etc. in the above formula examples include alkyl groups (eg, methyl, ethyl, propyl, isopropyl, butyl, pentyl, hexyl, octyl, decyl, dodecyl, octadecyl, eicosyl, etc.). It is a group selected from an aryl group (eg, phenyl, naphthyl, etc.), an aralkyl group (eg, benzyl, phenylethyl, etc.), a tolyl group, a xylyl group, and a cyclohexyl group.
  • alkyl groups eg, methyl, ethyl, propyl, isopropyl, butyl, pentyl, hexyl, octyl, decyl, dodecyl, octadecyl, eicosy
  • examples of the divalent organic group represented by Y are -R ",-, -R,, -C0-, -R ,,, -CO-, -R", -NHC0NH -R “"-NHC0- -R ,,, -OOCNH-R ,,,,-NHC0-, wherein R "is a divalent alkylene group, for example, ethylene, propylene, butylene, and R ' , "divalent alkylene group, for example R” ,, or divalent Ariren group, for example - C 6 H 4 -, -C 6 H 4 -C 6 H 4 -, -C 6 H 4 -CH 2 - And C 6 H 4 —, —C 6 H 4 —CH (C3 ⁇ 4) 2 —C 6 H 4 —, and the like, and preferably R, “, is a phenylene group).
  • divalent organic group - C C3 ⁇ 4 -, - CH 2 CH 2 CH 2 -, -CH 2 CH 2 C3 ⁇ 4C -, - (C3 ⁇ 4) 2 C0 -, - (C3 ⁇ 4) 3 NHC0- ,-(CH 2 ) 3 NHCONHC 6 H 4 NHCO-,-(CH 2 ) 3 00 CNC 6 H 4 NHC 0-, and the like.
  • Most preferred Y is a divalent alkylene group, especially —C3 ⁇ 4CH 2 C—.
  • the non-hydrolyzable copolymer described above reacts a polyoxyalkylene compound having a reactive terminal group with a dihydrocarbyl siloxane liquid having a terminal group that reacts with the reactive terminal group of the polyoxyalkylene compound. It can be manufactured by exercising.
  • the polyoxyalkylene compound includes polyoxyethylene, polyoxypropylene, polyoxybutylene, mixed polyoxyethylene mono-propylene and the like.
  • mixed polyoxyethylene-oxypropylene is more preferable because of its excellent blending stability.
  • C3 ⁇ 4 C (C3 ⁇ 4) - obtained by the reaction of dimethyl over polysiloxane having Poriokishia alkylene compound having a group at both ends and i (CH 3) 2 0- groups at both ends - CH 2
  • the block copolymer having the linear polysiloxane-polyoxyalkylene block as a repeating unit must have an HLB of 6 or less.
  • HLB is 6 or less, when it comes into contact with moisture, it has high water resistance without being emulsified and dissolved, and at the same time has the effect of preventing the penetration of irritants into the skin, and has an effect of protecting the skin.
  • This HLB is more preferably 4 or less from the viewpoint of further improving the water resistance. HLB can be determined by the following method.
  • the cloudiness number A is measured, and is calculated by the following equation.
  • the cloudiness number A is defined as a linear copolymer obtained by dissolving 0.5 g of a block copolymer having repeating units of a polysiloxane-polyoxyalkylene block in 5 inL of ethanol and maintaining the temperature at 25 ° C by 2%. —2% required for titration with aqueous phenol solution (the end point is when the solution becomes turbid) —The number of mL of aqueous phenol solution.
  • the polyoxyalkylene block and the skin surface have an interaction such as hydrogen bonding, they have an adhesive force to the skin as compared with ordinary baby oil etc. made of liquid paraffin, etc. Protects skin from rubbing of cloth etc. without peeling.
  • component (A) since component (A) is not solid, it does not hinder the movement of the skin and does not cause any discomfort.
  • the component (A) has a low stickiness and is very easy to apply. Even if it is applied to wet skin, it can be applied without any problem and exerts a skin protection effect.
  • the content of the component (A) is preferably 3 to 50% by weight, more preferably 5 to 20% by weight of the liquid skin protective composition.
  • the component (B) of the present invention includes at least one or more oils of mineral oil, animal oil, vegetable oil, synthetic oil and organopolysiloxane other than the component (A). These oils have a moisturizing effect on the skin through an emollient effect, and prevent excessive drying. It also works to supplement sebum components and enhance skin barrier function. It also improves the water repellency and water resistance of the skin protective agent. In addition, the lubricating effect has the effect of reducing friction on the skin surface.
  • mineral oils such as mineral oil, liquid paraffin, liquid isoparaffin, naphthenic oil, and petrolatum; olive oil, jojoba oil, cottonseed oil, peanut oil, castor oil, sunflower oil, coconut oil, almond oil, Vegetable oils such as oil, safflower oil, corn oil, soybean oil, hardened castor oil, hardened palm oil; animal oils such as mink oil, turtle oil, guinea pig oil, squalane, tallow, lanolin; polyalphaolefin oil, poly Synthesis of ester oils such as alkylene glycol oil, polybutene oil, isopropyl myristate, octyl phthalate, getyl hexyl phthalate, octyl dodecyl myristate, myristyl myristate, glycerin tri-2-ethylhexyl, and triglyceride stearate.
  • mineral oils such as mineral oil, liquid paraffin, liquid
  • the organopolysiloxanes include dimethylpolysiloxane and methylphenylpolysiloxane.
  • Examples include siloxane, silicone gum, alkyl-modified methylpolysiloxane, alkoxy-modified methylpolysiloxane, and amino-modified methylpolysiloxane. These can be used alone or in combination of two or more.
  • Component (B) is preferably at least 10% by weight of the liquid skin protectant composition, more preferably 30 to 97% by weight, and particularly preferably 50 to 95% by weight.
  • the component (B) preferably contains an oil agent (B-1) having a volatility of 0.2 mgZcmr or more and an oil agent (B-2) component having a volatility of 0.1 mg / cmr or less. More preferably, the component (B-2) contains two types of oils having a volatility of 0.1 ing / cm ⁇ r or less and a mutual solubility of 10% by weight or less.
  • the component (B-1) has a low viscosity, is easily stretched during use, has an effect of reducing stickiness and improving feel. Further, the component (B-2) is preferable for maintaining the water resistance of the present skin protective composition.
  • the volatility of the component (B-1) is preferably higher because the volatilization of the component (B_l) suppresses the diffusion of the skin protective agent composition on the skin, and the effect is more sustained and the feel is improved. Volatility can be measured as the unit surface area and the rate of weight loss per unit time when 10 g of oil is left in a petri dish of 11 marshals at 25 ° C atmospheric pressure, inner diameter 85 mm, depth 11.
  • the volatility of the component (B-1) is preferably from 0.2 to 5 OmgZcin 2 hr, more preferably from 0.3 to 20 mgZcm ⁇ r, and particularly preferably from 0.5 to 5 mgZcm3 ⁇ 4r.
  • the component (B-2) is preferred because the skin protective agent maintains water resistance and lubricity even when the component (B-1) evaporates when applied to the skin. (B-2)
  • the volatility at 25 ° C. is preferably 0.1 nig / cm3 ⁇ 4r or less, more preferably 0.03 mgZcm3 ⁇ 4r or less.
  • the component (B-1) includes volatile organopolysiloxane and volatile liquid isoparaffin. Also volatile on
  • the use of a cyclic methylcyclopolysiloxane such as decamethylcyclopentylsiloxane is particularly preferred from the viewpoints of low irritation and feel when sprayed by these uses.
  • the content of the component (B_l) is preferably 10% by weight or more, more preferably 30 to 80% by weight of the liquid skin protective composition.
  • the preferred component (B-2) is selected from liquid paraffin, liquid isoparaffin, squalane, isopropyl myristate, fatty acid tridalicelide, decamethylcyclopentylsiloxane, methylpolysiloxane, methylcyclopolysiloxane, and dimethylpolysiloxane. And more preferably one or more selected from liquid paraffin, liquid isoparaffin, squalane, methylcyclopolysiloxane and dimethylpolysiloxane.
  • the component (B-2) preferably contains two types of oils having a mutual solubility of 10% by weight or less.
  • mutual solubility refers to the lower of the two types of oils, which is the concentration (weight% in the mixture) that becomes clear to cloudy when one oil is stirred and mixed with another oil.
  • the mutual solubility at 25 ° C. is preferably 10% by weight or less, more preferably 3% by weight or less. Particularly preferably, it is at most 1% by weight.
  • Such two components it is preferable to use such two components by mixing them at a ratio of 1Z4 to 4Z1 (wt / wt), and more preferably at a ratio of 1/2 to 2/1.
  • these combinations include a hydrocarbon oil having a relatively high molecular weight such as liquid paraffin and squalane and an organopolysiloxane such as dimethylpolysiloxane.
  • these components can be stably compounded by using the above-mentioned volatile organopolysiloxane or volatile liquid isoparaffin. At this time, the effect is exhibited by the phase separation of these components as the volatile components evaporate.
  • the viscosity of the above-mentioned hydrocarbon oil at 25 ° C is preferably 2 OmPa's or more, and the viscosity of the organoboroxiloxane at 25 ° C is preferably 1 OmPa's or more for obtaining high lubricity. More preferably, the viscosity of the hydrocarbon oil at 25 ° C is 4 OmPa's or more, and the viscosity of the organopolysiloxane at 25 ° C is 2 OmPa's or more.
  • the component (B-2) is preferably contained in an amount of at least 10% by weight of the liquid skin protective agent composition, more preferably from 20 to 80% by weight, particularly preferably from 30 to 60% by weight.
  • the water content in the liquid skin protective composition of the present invention is 10% by weight or less, preferably 3% by weight or less, more preferably 1% by weight or less.
  • the content of water in the composition is 10% by weight or less, the viscosity of the entire composition is reduced, and the application becomes chewy.
  • water has a very large latent heat of vaporization, it is not desirable to use it in areas that give a cool sensation and are sensitive to stimuli.
  • the amount of water is less than 3% by weight, the cooling sensation is very small, and when the amount is less than 1% by weight, the cooling sensation is hardly felt. Also, a small amount of water has the effect of reducing friction on the skin.
  • the liquid skin protective composition of the present invention is liquid at room temperature (25 ° C.) and preferably has a low viscosity.
  • the viscosity is preferably 7 OmPa's or less at 25 ° C, more preferably 5 OmPa's or less, and particularly preferably 3 OmPa's or less. If the viscosity is low, it spreads easily on the skin when applied. It can also be applied over a wide area by spraying.
  • Examples of the monohydric alcohol having 1 to 4 carbon atoms include ethanol, methanol, isopropanol, 1-propanol and butyl alcohol.
  • the content of the monohydric alcohol having 1 to 4 carbon atoms is more preferably 3% by weight or less, and particularly preferably 1% by weight or less.
  • the liquid skin protective composition of the present invention is mainly used for, for example, ass, a peripheral part of a colostomy, and a skin around a wound. Even when used on very sensitive skin areas, it does not cause irritation such as bleeding on the skin, and does not cause skin irritation when used continuously.
  • an anti-inflammatory agent can be added to the liquid skin protective agent composition of the present invention. Inflammation such as diaper rash, redness, and contact dermatitis can be prevented by adding an anti-inflammatory agent. Even when the content of the anti-inflammatory agent is small, it can remain on the skin for a long time by being incorporated into the liquid skin protective composition, and a high effect can be expected.
  • the anti-inflammatory agent is not particularly limited, and examples thereof include guaiazulene, allantoin, soy lecithin, anethole, linalyl acetate, tempinyl acetate, glycyrrhetinic acid, stearyl glycyrrhetinate, dipotassium glycyrrhizinate, hydrocortisone acetate and the like.
  • a compound having high lipophilicity such as guaiazulene is preferable from the viewpoint of compoundability.
  • the content is 1% by weight or less of the liquid skin protective agent composition, preferably 0.001% to 0.2% by weight, more preferably 0.0005% to 0.2% by weight. 1% by weight.
  • the liquid skin protectant composition of the present invention is used for sites that are likely to come into contact with bacteria that cause inflammation of the skin (also referred to as causative bacteria), such as stool and wound exudate. Prevent infectious diseases caused by pathogenic bacteria such as urinary tract infection Can be.
  • the bactericide is not particularly limited, but since the bactericide itself is known to have skin irritation, a bactericidal agent that has minimal skin irritation is preferred. Further, those having high lipophilicity are preferable from the viewpoint of stability at the time of compounding. Specific examples include isopropylmethylphenol, triclosan, benzalkonium chloride, benzethonium chloride, and chlorhexidine dalconate.
  • the content is 0.001% to 1% by weight, preferably 0.0005% to 0.2% by weight, more preferably 0.0% by weight of the composition of the present application as an active ingredient. It is from 0.1% by weight to 0.05% by weight.
  • the liquid skin protective composition of the present invention does not contain an inorganic powder such as a pigment. Without inorganic powder, the liquid skin protective agent can be easily peeled off by washing, has a high lubricating effect, and does not clog the nozzle when used as a spray.
  • the liquid skin protectant composition of the present invention may further comprise, in addition to the above components, a humectant, an antioxidant, a blood circulation promoter, a preservative, as required, in a quantitative and qualitative range that does not impair the effects of the present invention. Deodorants, ultraviolet absorbers, coloring agents, fragrances, etc. can be added.
  • the liquid skin protective composition of the present invention can be produced according to a conventional method by adding the above optional components to the above essential components as necessary.
  • the content of these optional components can be contained in the composition at 30% by weight or less.
  • the form of the liquid skin protective composition of the present invention may be any of liquid, mist, and foam.
  • Use forms include aerosol spray, pump spray, pump pot, tube, absorbent cotton * paper * cloth impregnated, etc. Is desirable. Sprays can be applied in a non-contact manner, eliminating the need for hand washing after use.
  • a pump spray container that does not use a propellant such as liquefied gas or carbon dioxide gas is most preferable because it does not have heat of vaporization of the propellant and therefore has little irritation or coolness to the skin.
  • a pump spray container that does not use a propellant such as liquefied gas or carbon dioxide gas is most preferable because it does not have heat of vaporization of the propellant and therefore has little irritation or coolness to the skin.
  • a pump spray container that does not use a propellant such as liquefied gas or carbon dioxide gas is most preferable because it does not have heat of vaporization of the propellant and therefore has little irritation or coolness to the skin.
  • it when imp
  • liquid skin protectant compositions of Examples 1 to 7 and Comparative Examples 1 to 4 whose compositions (by weight) are shown in Tables 1 and 2 were produced by a conventional method.
  • the measurement was performed at 25 ° C using a B-type viscometer.
  • the color of the skin was measured with a color difference meter (ND300A spectroscopic color difference meter manufactured by Nippon Denshoku Industries Co., Ltd.).
  • the aqueous solution was brought into contact with the skin to which the liquid skin protective composition was applied for 5 minutes, and then washed to remove the liquid skin protective composition, and the color of the skin was measured with a color difference meter.
  • the color difference ( ⁇ E) is determined from the color of the treated skin and the color of the skin before contact with the pigment solution and before applying the liquid skin protective agent composition according to JISZ8730. In comparison with the color difference ( ⁇ ⁇ .)
  • the dye solution was brought into contact with the uncoated area, the degree of skin coloration was prevented, but the skin protection effect (%) was obtained by the following formula. It is.
  • the liquid skin protectant composition was applied as a model skin to a polyurethane foam (Mitsubishi Matsumoto, manufactured by Okamoto Co., Ltd.) at 3 mg / cm 2 and left at room temperature for 2 hours or more.
  • the friction between the standard sample and cotton cloth was measured with a KES surface property tester (manufactured by Kato Tech Co., Ltd.) to obtain a friction coefficient.
  • the spray amount of the liquid skin protective agent composition by the pump type spray container was about 0.2 g per time, and the spray was sprayed on the buttocks about 4 times.
  • the liquid skin protectant composition of Example 7 was impregnated into a cotton spunlace nonwoven fabric (Cot Ace, manufactured by Unitika, ⁇ 40 g).
  • the impregnated amount of the liquid skin protective agent composition was 150% of the weight of the nonwoven fabric, and the size per sheet was 15 Omm X 19 Omm.
  • Tables 1 and 2 show the evaluation results. The numbers in the evaluation results indicate the number of people.
  • Tables 1 and 2 show the following. That is, the compositions of Examples 1 to 6 have good sprayability at room temperature. Further, the compositions of Examples 1 to 7 have no irritation at the time of application, have a smooth and very good feel, and have a very good skin protection effect. In the composition of Comparative Example 1, the skin protection effect is significantly reduced. The composition of Comparative Example 2 has good coatability and feel, but has a very low skin protection effect. Comparative example In the composition of No. 3, the sprayability of the spray is remarkably poor, and it is difficult to apply to the skin and the feeling is poor. Also, the skin protection effect is significantly reduced. In the composition of Comparative Example 4, the skin after application had a tight feeling on the skin, a poor feeling, and no remarkable skin protection effect. Industrial applicability
  • the liquid skin protectant composition of the present invention has a high skin protection effect, is easy to apply, has no irritation to the skin, and has a good feel. Therefore, it can be used to protect the skin of diaper use areas, such as babies and incontinent persons, the area around the stoma, and the area around the wound with exudate.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
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  • Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

La présente invention concerne composition dermoprotectrice liquide protégeant la peau contre des substances chimiques présentes dans l'environnement et contre des substances aqueuses irritantes telles que les fluides anatomiques, les excréments et les exsudats. Cette composition qui est faiblement irritante, est facile à étendre et procure une sensation agréable. Cette composition dermoprotectrice liquide, qui réunit les deux ingrédients A et B suivants, contient également de l'eau représentant 10 % au maximum de sa masse. L'ingrédient A est in copolymère bloc structuré par au moins un bloc de polysiloxane/polyoxyalkylène linéaire et présentant un rapport hydrophile-lipophile n'excédant pas 6. L'ingrédient B est au moins une huile appartenant au groupe des huiles minérales, végétales, animales, synthétiques et des organopolysiloxanes autres que l'ingrédient A.
PCT/JP2003/013545 2002-11-01 2003-10-23 Composition dermoprotectrice liquide WO2004039347A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2003275610A AU2003275610A1 (en) 2002-11-01 2003-10-23 Liquid skin protective composition
US10/533,235 US20060039885A1 (en) 2002-11-01 2003-10-23 Liquid skin protective composition
EP03758814A EP1559415A4 (fr) 2002-11-01 2003-10-23 Composition dermoprotectrice liquide
JP2004548031A JP4354914B2 (ja) 2002-11-01 2003-10-23 液状皮膚保護剤組成物

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JP2002319841 2002-11-01
JP2002-319841 2002-11-01

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WO2004039347A1 true WO2004039347A1 (fr) 2004-05-13

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US (1) US20060039885A1 (fr)
EP (1) EP1559415A4 (fr)
JP (1) JP4354914B2 (fr)
AU (1) AU2003275610A1 (fr)
WO (1) WO2004039347A1 (fr)

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JP2007015987A (ja) * 2005-07-08 2007-01-25 Kao Corp 角栓除去剤組成物
JP2007297382A (ja) * 2006-03-21 2007-11-15 Access Business Group Internatl Llc 皮膚の反応を軽減する方法
JP2008534482A (ja) * 2005-03-24 2008-08-28 トランスフェイズ・リミテッド 局所用組成物およびその使用
JP2012530719A (ja) * 2009-06-18 2012-12-06 アドバンスド バイオ−テクノロジーズ，インコーポレイテッド 瘢痕治療用シリコーン製剤
JP2015110545A (ja) * 2013-10-28 2015-06-18 株式会社ミルボン 油性組成物

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EP2896429B1 (fr) * 2014-01-20 2018-07-18 COR S.a.r.l. Protection de la peau
EP3378463A1 (fr) * 2017-03-20 2018-09-26 Total Marketing Services Utilisation non-therapeutique d'une huile hydrocarbonee biodegradable

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JP2002308729A (ja) * 2001-04-04 2002-10-23 Kansai Koso Kk 乳化組成物、それを含む乳化化粧料及び薬剤、並びに抗アレルギー剤

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JP2008534482A (ja) * 2005-03-24 2008-08-28 トランスフェイズ・リミテッド 局所用組成物およびその使用
JP2007015987A (ja) * 2005-07-08 2007-01-25 Kao Corp 角栓除去剤組成物
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JP2007297382A (ja) * 2006-03-21 2007-11-15 Access Business Group Internatl Llc 皮膚の反応を軽減する方法
JP2012530719A (ja) * 2009-06-18 2012-12-06 アドバンスド バイオ−テクノロジーズ，インコーポレイテッド 瘢痕治療用シリコーン製剤
JP2015110545A (ja) * 2013-10-28 2015-06-18 株式会社ミルボン 油性組成物

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JPWO2004039347A1 (ja) 2006-02-23
AU2003275610A1 (en) 2004-05-25
EP1559415A1 (fr) 2005-08-03
US20060039885A1 (en) 2006-02-23
JP4354914B2 (ja) 2009-10-28
EP1559415A4 (fr) 2010-06-23

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