WO2003020722A1 - Neue dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel - Google Patents
Neue dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel Download PDFInfo
- Publication number
- WO2003020722A1 WO2003020722A1 PCT/EP2002/009728 EP0209728W WO03020722A1 WO 2003020722 A1 WO2003020722 A1 WO 2003020722A1 EP 0209728 W EP0209728 W EP 0209728W WO 03020722 A1 WO03020722 A1 WO 03020722A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- group
- compound
- hydrogen
- optionally substituted
- Prior art date
Links
- 0 Cc(nc1*)nc(N(*)C2(*)*)c1N(*)C2O Chemical compound Cc(nc1*)nc(N(*)C2(*)*)c1N(*)C2O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Description
Claims
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2458699A CA2458699C (en) | 2001-09-04 | 2002-08-30 | Novel dihydropteridinones, method for producing the same and the use thereof as medicaments |
DE50207522T DE50207522D1 (de) | 2001-09-04 | 2002-08-30 | Neue dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel |
NZ531928A NZ531928A (en) | 2001-09-04 | 2002-08-30 | Novel dihydropteridinones, method for producing the same and the use thereof as medicaments |
SI200230406T SI1427730T1 (sl) | 2001-09-04 | 2002-08-30 | Novi dihidropteridinoni, postopek za njihovo pripravo in njihova uporaba kot zdravila |
UA2004042514A UA76512C2 (en) | 2001-09-04 | 2002-08-30 | Dihydropteridinones, a method for producing thereof and use thereof as medicament |
BRPI0212137A BRPI0212137A2 (pt) | 2001-09-04 | 2002-08-30 | diidropteridinonas, processos para prepará-las e seu uso como composições farmacêuticas |
EP02772249A EP1427730B1 (de) | 2001-09-04 | 2002-08-30 | Neue dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel |
KR1020047003248A KR100955589B1 (ko) | 2001-09-04 | 2002-08-30 | 신규한 디하이드로프테리디논, 이의 제조방법 및 이를 함유하는 약제학적 조성물 |
IL16044002A IL160440A0 (en) | 2001-09-04 | 2002-08-30 | Novel dihydropteridinones, method for producing the same and the use thereof as medicaments |
EA200400368A EA007062B1 (ru) | 2001-09-04 | 2002-08-30 | Новые дигидроптеридиноны, способы их получения и их применение в качестве лекарственных средств |
MXPA04002067A MXPA04002067A (es) | 2001-09-04 | 2002-08-30 | Nuevas dihidropteridinonas, procedimientos para su preparacion y su uso como medicamento. |
AU2002337047A AU2002337047B2 (en) | 2001-09-04 | 2002-08-30 | Novel dihydropteridinones, method for producing the same and the use thereof as medicaments |
JP2003524992A JP3876254B2 (ja) | 2001-09-04 | 2002-08-30 | 新規なジヒドロプテリジノン、その製造方法及びその医薬組成物としての使用 |
HU0401293A HUP0401293A3 (en) | 2001-09-04 | 2002-08-30 | Novel dihydropteridinones, method for producing the same and the use thereof as medicaments |
NO20040680A NO328804B1 (no) | 2001-09-04 | 2004-02-16 | Nye dihydropterinoner, fremgangsmate for deres fremstilling og deres anvendelse |
IL160440A IL160440A (en) | 2001-09-04 | 2004-02-17 | Dihydropteridinones, method for producing the same and the use thereof as medicaments |
HR20040213A HRP20040213A2 (en) | 2001-09-04 | 2004-03-03 | Novel dihydropteridinones, method for producing the same and the use thereof as medicaments |
CY20061101285T CY1105337T1 (el) | 2001-09-04 | 2006-09-08 | Πρωτοτυπες διυδροπτepιδινονες, μεθοδος για την παραγωγη τους και η χρηση τους ως φαρμακευτικα μεσα |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10143272.0 | 2001-09-04 | ||
DE10143272 | 2001-09-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003020722A1 true WO2003020722A1 (de) | 2003-03-13 |
Family
ID=7697637
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2002/009728 WO2003020722A1 (de) | 2001-09-04 | 2002-08-30 | Neue dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel |
Country Status (30)
Country | Link |
---|---|
EP (1) | EP1427730B1 (de) |
JP (1) | JP3876254B2 (de) |
KR (1) | KR100955589B1 (de) |
CN (1) | CN1551881A (de) |
AR (1) | AR036586A1 (de) |
AT (1) | ATE332898T1 (de) |
AU (1) | AU2002337047B2 (de) |
BR (1) | BRPI0212137A2 (de) |
CA (1) | CA2458699C (de) |
CO (1) | CO5560575A2 (de) |
CY (1) | CY1105337T1 (de) |
DE (1) | DE50207522D1 (de) |
DK (1) | DK1427730T3 (de) |
EA (1) | EA007062B1 (de) |
EC (1) | ECSP045003A (de) |
ES (1) | ES2268093T3 (de) |
HR (1) | HRP20040213A2 (de) |
HU (1) | HUP0401293A3 (de) |
IL (2) | IL160440A0 (de) |
MX (1) | MXPA04002067A (de) |
MY (1) | MY129751A (de) |
NO (1) | NO328804B1 (de) |
NZ (1) | NZ531928A (de) |
PL (1) | PL369740A1 (de) |
PT (1) | PT1427730E (de) |
RS (1) | RS51012B (de) |
UA (1) | UA76512C2 (de) |
UY (1) | UY27427A1 (de) |
WO (1) | WO2003020722A1 (de) |
ZA (1) | ZA200401365B (de) |
Cited By (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1363884A2 (de) * | 2001-02-02 | 2003-11-26 | Icagen, Inc. | Pyridinsubstituierte benzanilide als kaliumionenkanalöffner |
WO2004076454A1 (de) * | 2003-02-26 | 2004-09-10 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel |
WO2005123736A1 (de) * | 2004-06-21 | 2005-12-29 | Boehringer Ingelheim International Gmbh | Neue 2-benzylaminodihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel |
WO2006005510A1 (de) * | 2004-07-09 | 2006-01-19 | Boehringer Ingelheim International Gmbh | Neue pyridodihydropyrazinone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US6989398B2 (en) | 1999-08-04 | 2006-01-24 | Icagen, Inc. | Benzanilides as potassium channel openers |
WO2006018221A1 (de) * | 2004-08-14 | 2006-02-23 | Boehringer Ingelheim International Gmbh | Lagerstabile infusionslösung von dihydropteridinonen |
WO2006018182A1 (en) * | 2004-08-14 | 2006-02-23 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
WO2006018222A1 (de) * | 2004-08-14 | 2006-02-23 | Boehringer Ingelheim International Gmbh | Hydrate und polymorphe des 4-[[(7r)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-4-6-oxo-2-piperidinyl]amino]-3-methoxy-n-(1-methyl-4-piperidinyl)-benzamid, verfahren zu deren herstellung und deren verwendung als arzneimittel |
WO2006018220A2 (de) * | 2004-08-14 | 2006-02-23 | Boehringer Ingelheim International Gmbh | Verfahren zur herstellung von dihydropteridinonen |
WO2006018185A2 (en) | 2004-08-14 | 2006-02-23 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
EP1630163A1 (de) * | 2004-08-25 | 2006-03-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
WO2006021548A1 (de) * | 2004-08-27 | 2006-03-02 | Boehringer Ingelheim International Gmbh | Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel |
WO2006021378A1 (de) * | 2004-08-25 | 2006-03-02 | Boehringer Ingelheim International Gmbh | Dihydropteridinonderivate, verfahren zu deren herstellung und deren verwendung als arzneimittel |
WO2006058876A1 (de) | 2004-12-02 | 2006-06-08 | Boehringer Ingelheim International Gmbh | Verfahren zur herstellung von annelierten piperazin-2-on derivaten sowie zwischenprodukte des verfahrens |
WO2007014838A1 (en) * | 2005-08-03 | 2007-02-08 | Boehringer Ingelheim International Gmbh | Dihydropteridinones in the treatment of respiratory diseases |
WO2007090844A1 (en) * | 2006-02-08 | 2007-08-16 | Boehringer Ingelheim International Gmbh | Trihydrochloride forms of a dihydropteridinone derivative and processes for preparation |
WO2007135374A1 (en) * | 2006-05-19 | 2007-11-29 | Astrazeneca Ab | Dihydropteridine compounds as anti proliferative agents |
WO2008003958A2 (en) * | 2006-07-06 | 2008-01-10 | Astrazeneca Ab | Fused pyrimido compounds |
WO2008009909A1 (en) * | 2006-07-17 | 2008-01-24 | Astrazeneca Ab | Pteridimones as modulators of polo-like kinase |
WO2008040951A1 (en) * | 2006-10-03 | 2008-04-10 | Astrazeneca Ab | Compounds |
WO2008113711A1 (en) | 2007-03-22 | 2008-09-25 | F. Hoffmann-La Roche Ag | Substituted pyrimidodiazepines useful as plk1 inhibitors |
WO2008157235A1 (en) * | 2007-06-13 | 2008-12-24 | University Of Virginia Patent Foundation | Rsk inhibitors as anti-septicemia agents |
WO2009071480A2 (en) * | 2007-12-04 | 2009-06-11 | Nerviano Medical Sciences S.R.L. | Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors |
EP2100894A1 (de) | 2008-03-12 | 2009-09-16 | 4Sc Ag | Pyridopyrimidinone verwendbar als Plk1 (polo-like kinase) Hemmen |
WO2009111868A1 (en) | 2008-03-11 | 2009-09-17 | University Health Network | Method of treating cancer using a neuropeptide y 5r (np y5r) antagonist |
EP2112152A1 (de) | 2008-04-22 | 2009-10-28 | GPC Biotech AG | Dihydropteridinones als Plk-Inhibitoren |
US7622463B2 (en) | 2006-02-14 | 2009-11-24 | Vertex Pharmaceuticals Incorporated | Dihydrodiazepines useful as inhibitors of protein kinases |
WO2009141575A1 (en) * | 2008-04-24 | 2009-11-26 | Chroma Therapeutics Ltd. | Inhibitors of plk |
US20100099680A1 (en) * | 2007-02-01 | 2010-04-22 | Boehringer Ingelheim International Gmbh | Pteridinone derivatives as p13-kinases inhibitors |
US7750152B2 (en) | 2003-02-26 | 2010-07-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Intermediate compounds for making dihydropteridinones useful as pharmaceutical compositions and processes of making the same |
WO2011035534A1 (zh) | 2009-09-22 | 2011-03-31 | 江苏恒瑞医药股份有限公司 | 二氢喋啶酮类衍生物、其制备方法及其在医药上的应用 |
EP2325185A1 (de) | 2009-10-28 | 2011-05-25 | GPC Biotech AG | Plk-Inhibitor |
WO2011079118A1 (en) | 2009-12-23 | 2011-06-30 | Elan Pharmaceuticals, Inc | Pteridinones as inhibitors of polo-like kinase |
US8003785B2 (en) | 2008-06-18 | 2011-08-23 | Takeda Pharmaceutical Company Limited | Halo-substituted pyrimidodiazepines |
WO2011101369A1 (en) | 2010-02-17 | 2011-08-25 | Boehringer Ingelheim International Gmbh | Dihydropteridinones, method for production and use thereof |
US8026234B2 (en) | 2007-09-25 | 2011-09-27 | Takeda Pharmaceutical Company Limited | Polo-like kinase inhibitors |
US8093043B2 (en) | 2008-06-04 | 2012-01-10 | New York University | β-TrCP1, β-TrCP2 and RSK1 or RSK2 inhibitors and methods for sensitizing target cells to apoptosis |
CN102548994A (zh) * | 2009-09-25 | 2012-07-04 | 沃泰克斯药物股份有限公司 | 用于制备用作蛋白激酶抑制剂的嘧啶衍生物的方法 |
US8329695B2 (en) | 2007-08-03 | 2012-12-11 | Boehringer Ingelheim International Gmbh | Crystalline form of the free base N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7r)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide |
US8367670B2 (en) | 2008-12-09 | 2013-02-05 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
US8476270B2 (en) | 2009-09-14 | 2013-07-02 | Gilead Sciences, Inc. | Dihydropyrido[4,3-b]pyrazine-3-ones as modulators of toll-like receptors |
US8546566B2 (en) | 2010-10-12 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Process for manufacturing dihydropteridinones and intermediates thereof |
US8637666B2 (en) | 2009-09-25 | 2014-01-28 | Vertex Pharmaceuticals Incorporated | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors |
WO2014127815A1 (en) * | 2013-02-21 | 2014-08-28 | Boehringer Ingelheim International Gmbh | Dihydropteridinones i |
WO2014127816A1 (en) * | 2013-02-21 | 2014-08-28 | Boehringer Ingelheim International Gmbh | Dihydropteridinones ii |
US8865716B2 (en) | 2012-02-23 | 2014-10-21 | Boehringer Ingelheim International Gmbh | Dihydropteridinones II |
US9006226B2 (en) | 2012-02-23 | 2015-04-14 | Boehringer Ingelheim International Gmbh | Dihydropteridinones I |
US9051269B2 (en) | 2011-11-18 | 2015-06-09 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
US9085583B2 (en) | 2012-02-10 | 2015-07-21 | Constellation—Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
US9206128B2 (en) | 2011-11-18 | 2015-12-08 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
WO2015193228A1 (de) * | 2014-06-19 | 2015-12-23 | Bayer Pharma Aktiengesellschaft | Bet-proteininhibitorische 1,4-dihydropyrido[3,4-b]pyrazinone mit para-substituierter aromatischer amino- oder ethergruppe |
WO2015193229A1 (de) * | 2014-06-19 | 2015-12-23 | Bayer Pharma Aktiengesellschaft | Bet-proteininhibitorische 1,4-dihydropyrido[3,4-b]pyrazinone mit meta-substituierter aromatischer amino- oder ethergruppe |
US9358233B2 (en) | 2010-11-29 | 2016-06-07 | Boehringer Ingelheim International Gmbh | Method for treating acute myeloid leukemia |
US9370535B2 (en) | 2011-05-17 | 2016-06-21 | Boehringer Ingelheim International Gmbh | Method for treatment of advanced solid tumors |
US9573952B2 (en) | 2014-09-16 | 2017-02-21 | Gilead Sciences, Inc. | Methods of preparing toll-like receptor modulators |
US9745305B2 (en) | 2013-03-15 | 2017-08-29 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
DE102017005091A1 (de) | 2016-05-30 | 2017-11-30 | Bayer Pharma Aktiengesellschaft | Substituierte 3,4-Dihydropyrido[2,3-b]pyrazin-2(1H)-one |
DE102017005089A1 (de) | 2016-05-30 | 2017-11-30 | Bayer Pharma Aktiengesellschaft | Substitulerte 3,4-Dihydrochinoxalin-2(1H)-one |
US9867831B2 (en) | 2014-10-01 | 2018-01-16 | Boehringer Ingelheim International Gmbh | Combination treatment of acute myeloid leukemia and myelodysplastic syndrome |
US9956225B2 (en) | 2013-07-26 | 2018-05-01 | Boehringer Ingelheim International Gmbh | Treatment of myelodysplastic syndrome |
US9969716B2 (en) | 2013-08-15 | 2018-05-15 | Constellation Pharmaceuticals, Inc. | Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof |
US9975896B2 (en) | 2013-07-25 | 2018-05-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcription factors and uses thereof |
US10150756B2 (en) | 2014-01-31 | 2018-12-11 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
US10202384B2 (en) | 2014-09-16 | 2019-02-12 | Gilead Sciences, Inc. | Solid forms of a toll-like receptor modulator |
US10308653B2 (en) | 2014-08-08 | 2019-06-04 | Dana-Farber Cancer Institute, Inc. | Diazepane derivatives and uses thereof |
US10457640B2 (en) | 2016-10-19 | 2019-10-29 | Constellation Pharmaceuticals, Inc. | Synthesis of inhibitors of EZH2 |
WO2019209757A1 (en) * | 2018-04-24 | 2019-10-31 | Vertex Pharmaceuticals Incorporated | Pteridinone compounds and uses thereof |
WO2020033823A1 (en) * | 2018-08-10 | 2020-02-13 | Yale University | Small-molecule pi5p4k alpha/beta inhibitors and methods of treatment using same |
US10577350B2 (en) | 2015-08-28 | 2020-03-03 | Constellation Pharmaceuticals, Inc. | Crystalline forms of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide |
US10702527B2 (en) | 2015-06-12 | 2020-07-07 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
US10793571B2 (en) | 2014-01-31 | 2020-10-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
US10881668B2 (en) | 2015-09-11 | 2021-01-05 | Dana-Farber Cancer Institute, Inc. | Acetamide thienotriazolodiazepines and uses thereof |
US10913752B2 (en) | 2015-11-25 | 2021-02-09 | Dana-Farber Cancer Institute, Inc. | Bivalent bromodomain inhibitors and uses thereof |
JP2021020957A (ja) * | 2014-12-23 | 2021-02-18 | ダナ−ファーバー キャンサー インスティテュート,インコーポレイテッド | 二官能性分子によって標的化タンパク質分解を誘導する方法 |
US11116774B2 (en) | 2014-07-11 | 2021-09-14 | Gilead Sciences, Inc. | Modulators of toll-like receptors for the treatment of HIV |
US11306105B2 (en) | 2015-09-11 | 2022-04-19 | Dana-Farber Cancer Institute, Inc. | Cyano thienotriazolodiazepines and uses thereof |
EP3868762A4 (de) * | 2018-10-12 | 2022-06-29 | Hefei Institutes of Physical Science, Chinese Academy of Sciences | Mst1-kinasehemmer und verwendung davon |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA200902382B (en) | 2006-10-19 | 2010-08-25 | Signal Pharm Llc | Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors |
CA2695753A1 (en) * | 2007-08-15 | 2009-02-19 | Vertex Pharmaceuticals Incorporated | Compounds useful as protein kinases inhibitors |
US8110578B2 (en) | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
ES2751705T3 (es) | 2009-10-26 | 2020-04-01 | Signal Pharm Llc | Métodos de síntesis y purificación de compuestos heteroarilo |
UA115319C2 (uk) | 2011-10-19 | 2017-10-25 | Сігнал Фармасьютікалз, Елелсі | Лікування злоякісної пухлини інгібітором тоr-кінази |
CA3125862A1 (en) | 2011-12-02 | 2013-06-06 | Signal Pharmaceuticals, Llc | Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use |
US9375443B2 (en) | 2012-02-24 | 2016-06-28 | Signal Pharmaceuticals, Llc | Method for treating advanced non-small cell lung cancer (NSCLC) by administering a combination of a TOR kinase inhibitor and azacitidine or erlotinib |
AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
ES2638179T3 (es) | 2013-01-16 | 2017-10-19 | Signal Pharmaceuticals, Llc | Compuestos de pirrolopirimidina sustituidos, composiciones de los mismos, y métodos de tratamiento con los mismos |
MX2015014590A (es) | 2013-04-17 | 2016-03-03 | Signal Pharm Llc | Tratamiento de cancer con dihidropirazino-pirazinas. |
EA030726B1 (ru) | 2013-04-17 | 2018-09-28 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | ФАРМАЦЕВТИЧЕСКИЕ СОСТАВЫ, СПОСОБЫ, ТВЕРДЫЕ ФОРМЫ И СПОСОБЫ ПРИМЕНЕНИЯ, ОТНОСЯЩИЕСЯ К 1-ЭТИЛ-7-(2-МЕТИЛ-6-(1H-1,2,4-ТРИАЗОЛ-3-ИЛ)ПИРИДИН-3-ИЛ)-3,4-ДИГИДРОПИРАЗИНО[2,3-b]ПИРАЗИН-2(1H)-ОНУ |
US9937169B2 (en) | 2013-04-17 | 2018-04-10 | Signal Pharmaceuticals, Llc | Methods for treating cancer using dihydropyrazino-pyrazine compound combination therapy |
CA2909625C (en) | 2013-04-17 | 2021-06-01 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer |
EA030808B1 (ru) | 2013-04-17 | 2018-09-28 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | ПРИМЕНЕНИЕ 1-ЭТИЛ-7-(2-МЕТИЛ-6-(1Н-1,2,4-ТРИАЗОЛ-3-ИЛ)ПИРИДИН-3-ИЛ)-3,4-ДИГИДРОПИРАЗИНО[2,3-b]ПИРАЗИН-2(1Н)-ОНА В ЛЕЧЕНИИ МУЛЬТИФОРМНОЙ ГЛИОБЛАСТОМЫ |
CA2908742C (en) | 2013-04-17 | 2021-06-01 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer |
CN105339008A (zh) | 2013-04-17 | 2016-02-17 | 西格诺药品有限公司 | 用于治疗癌症的包括tor激酶抑制剂和n-(3-(5-氟-2-(4-(2-甲氧基乙氧基)苯基氨基)嘧啶-4-基氨基)苯基)丙烯酰胺的组合疗法 |
MX2015015880A (es) | 2013-05-29 | 2016-05-31 | Signal Pharm Llc | Composiciones farmaceuticas de 7-(6-(2-hidroxipropan-2-il)piridin- 3-il)-1-((trans)-4-metoxiciclohexil)-3,4-dihidropirazino[2,3-b]pi razin-2(1h)-ona, una forma solida del mismo y metodos de su uso. |
CN105518001A (zh) * | 2013-07-09 | 2016-04-20 | 拜耳制药股份公司 | Bet蛋白抑制性的改性的二氢喹喔啉酮类化合物和二氢吡啶并吡嗪酮类化合物 |
CN103664845B (zh) * | 2013-12-27 | 2016-02-10 | 湖南欧亚生物有限公司 | 一种Plk激酶抑制剂药物中间体7-氨基-2,3-二氢苯并呋喃-4-甲酸的制备方法 |
NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
EP3131552B1 (de) | 2014-04-16 | 2020-07-15 | Signal Pharmaceuticals, LLC | Verfahren zur behandlung von krebs anhand einer tor-kinasehemmerkombinationstherapie |
WO2015160880A1 (en) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF |
US9718824B2 (en) | 2014-04-16 | 2017-08-01 | Signal Pharmaceuticals, Llc | Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof |
NZ629796A (en) | 2014-07-14 | 2015-12-24 | Signal Pharm Llc | Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use |
JP2017520603A (ja) | 2014-07-14 | 2017-07-27 | シグナル ファーマシューティカルズ,エルエルシー | 置換ピロロピリミジン化合物を使用するがんの治療方法及びその組成物 |
CN110996955A (zh) | 2017-06-22 | 2020-04-10 | 细胞基因公司 | 以乙型肝炎病毒感染为特征的肝细胞癌的治疗 |
AU2018392805A1 (en) * | 2017-12-22 | 2020-05-07 | Dana-Farber Cancer Institute, Inc. | NEK inhibitors and methods of use |
CN108610343A (zh) * | 2018-06-12 | 2018-10-02 | 杨文思 | 一种用于治疗癌症的表皮生长因子受体抑制剂及其合成方法 |
CN113637017B (zh) * | 2021-08-12 | 2024-03-26 | 中国药科大学 | 含二氢喋呤结构的化合物及其制备方法与用途 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0399856A1 (de) * | 1989-03-30 | 1990-11-28 | Lipha, Lyonnaise Industrielle Pharmaceutique | Pteridin-4 (3H)-onen, Verfahren zu ihrer Herstellung und sie enthaltende Medikamente |
EP0429149A1 (de) * | 1989-11-17 | 1991-05-29 | Berlex Laboratories, Inc. | Tricyclische Pteridinone und ein Verfahren zu deren Herstellung |
US5698556A (en) * | 1995-06-07 | 1997-12-16 | Chan; Carcy L. | Methotrexate analogs and methods of using same |
WO2001019825A1 (en) * | 1999-09-15 | 2001-03-22 | Warner-Lambert Company | Pteridinones as kinase inhibitors |
WO2002076954A1 (en) * | 2001-03-23 | 2002-10-03 | Smithkline Beecham Corporation | Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases |
-
2002
- 2002-08-30 WO PCT/EP2002/009728 patent/WO2003020722A1/de active IP Right Grant
- 2002-08-30 JP JP2003524992A patent/JP3876254B2/ja not_active Expired - Lifetime
- 2002-08-30 MX MXPA04002067A patent/MXPA04002067A/es active IP Right Grant
- 2002-08-30 CN CNA028172884A patent/CN1551881A/zh active Pending
- 2002-08-30 DE DE50207522T patent/DE50207522D1/de not_active Expired - Lifetime
- 2002-08-30 DK DK02772249T patent/DK1427730T3/da active
- 2002-08-30 EA EA200400368A patent/EA007062B1/ru not_active IP Right Cessation
- 2002-08-30 NZ NZ531928A patent/NZ531928A/en not_active IP Right Cessation
- 2002-08-30 CA CA2458699A patent/CA2458699C/en not_active Expired - Lifetime
- 2002-08-30 BR BRPI0212137A patent/BRPI0212137A2/pt not_active IP Right Cessation
- 2002-08-30 IL IL16044002A patent/IL160440A0/xx unknown
- 2002-08-30 EP EP02772249A patent/EP1427730B1/de not_active Expired - Lifetime
- 2002-08-30 AT AT02772249T patent/ATE332898T1/de active
- 2002-08-30 UY UY27427A patent/UY27427A1/es not_active Application Discontinuation
- 2002-08-30 PL PL02369740A patent/PL369740A1/xx not_active Application Discontinuation
- 2002-08-30 RS YUP-273/04A patent/RS51012B/sr unknown
- 2002-08-30 HU HU0401293A patent/HUP0401293A3/hu unknown
- 2002-08-30 AU AU2002337047A patent/AU2002337047B2/en not_active Ceased
- 2002-08-30 ES ES02772249T patent/ES2268093T3/es not_active Expired - Lifetime
- 2002-08-30 KR KR1020047003248A patent/KR100955589B1/ko not_active IP Right Cessation
- 2002-08-30 UA UA2004042514A patent/UA76512C2/uk unknown
- 2002-08-30 PT PT02772249T patent/PT1427730E/pt unknown
- 2002-09-02 MY MYPI20023275A patent/MY129751A/en unknown
- 2002-09-04 AR ARP020103334A patent/AR036586A1/es not_active Suspension/Interruption
-
2004
- 2004-02-16 NO NO20040680A patent/NO328804B1/no not_active IP Right Cessation
- 2004-02-17 IL IL160440A patent/IL160440A/en not_active IP Right Cessation
- 2004-02-19 ZA ZA200401365A patent/ZA200401365B/en unknown
- 2004-03-03 HR HR20040213A patent/HRP20040213A2/hr not_active Application Discontinuation
- 2004-03-04 EC EC2004005003A patent/ECSP045003A/es unknown
- 2004-03-04 CO CO04020069A patent/CO5560575A2/es not_active Application Discontinuation
-
2006
- 2006-09-08 CY CY20061101285T patent/CY1105337T1/el unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0399856A1 (de) * | 1989-03-30 | 1990-11-28 | Lipha, Lyonnaise Industrielle Pharmaceutique | Pteridin-4 (3H)-onen, Verfahren zu ihrer Herstellung und sie enthaltende Medikamente |
EP0429149A1 (de) * | 1989-11-17 | 1991-05-29 | Berlex Laboratories, Inc. | Tricyclische Pteridinone und ein Verfahren zu deren Herstellung |
US5698556A (en) * | 1995-06-07 | 1997-12-16 | Chan; Carcy L. | Methotrexate analogs and methods of using same |
WO2001019825A1 (en) * | 1999-09-15 | 2001-03-22 | Warner-Lambert Company | Pteridinones as kinase inhibitors |
WO2002076954A1 (en) * | 2001-03-23 | 2002-10-03 | Smithkline Beecham Corporation | Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases |
Cited By (187)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6989398B2 (en) | 1999-08-04 | 2006-01-24 | Icagen, Inc. | Benzanilides as potassium channel openers |
EP1363884A2 (de) * | 2001-02-02 | 2003-11-26 | Icagen, Inc. | Pyridinsubstituierte benzanilide als kaliumionenkanalöffner |
EP1363884A4 (de) * | 2001-02-02 | 2005-03-30 | Icagen Inc | Pyridinsubstituierte benzanilide als kaliumionenkanalöffner |
AU2003215591B2 (en) * | 2003-02-26 | 2010-06-17 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Dihydropteridinones, method for the production and use thereof in the form of drugs |
US8003786B2 (en) | 2003-02-26 | 2011-08-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinone compounds |
EA008778B1 (ru) * | 2003-02-26 | 2007-08-31 | Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг | Дигидроптеридиноны, способ их получения и их применение в качестве лекарственных средств |
US7786299B2 (en) | 2003-02-26 | 2010-08-31 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Methods for treating diseases or conditions using dihydropteridinone compounds |
US7750152B2 (en) | 2003-02-26 | 2010-07-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Intermediate compounds for making dihydropteridinones useful as pharmaceutical compositions and processes of making the same |
WO2004076454A1 (de) * | 2003-02-26 | 2004-09-10 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel |
US7816530B2 (en) | 2003-02-26 | 2010-10-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Piperazinyl compounds |
HRP20050735B1 (hr) * | 2003-02-26 | 2013-08-31 | Boehringer Ingelheim Pharma Gmbh & Co.Kg | Dihidropteridinoni, metoda za njihovu proizvodnju i upotrebu u obliku lijekova |
US7759347B2 (en) | 2004-06-21 | 2010-07-20 | Boehringer Ingelheim International Gmbh | 2-benzylaminodihydropteridinones, process for their manufacture and use thereof as medicaments |
JP2008503515A (ja) * | 2004-06-21 | 2008-02-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規2−ベンジルアミノジヒドロプテリジノン、それらを製造する方法及び薬剤としてのそれらの使用 |
WO2005123736A1 (de) * | 2004-06-21 | 2005-12-29 | Boehringer Ingelheim International Gmbh | Neue 2-benzylaminodihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel |
US7625899B2 (en) | 2004-07-09 | 2009-12-01 | Boehringer Ingelheim International Gmbh | Pyridodihydropyraziones, process for their manufacture and use thereof as medicaments |
US8193188B2 (en) | 2004-07-09 | 2012-06-05 | Boehringer Ingelheim International Gmbh | Methods of using pyridodihydropyrazinones |
WO2006005510A1 (de) * | 2004-07-09 | 2006-01-19 | Boehringer Ingelheim International Gmbh | Neue pyridodihydropyrazinone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
JP2008505157A (ja) * | 2004-07-09 | 2008-02-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ピリドジヒドロピラジノン、その製造方法及びその薬物としての使用 |
JP2008509949A (ja) * | 2004-08-14 | 2008-04-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌疾患の治療のためのジヒドロプテリジノン |
EP2275107A3 (de) * | 2004-08-14 | 2013-06-26 | Boehringer Ingelheim International GmbH | Kombinationen zur Behandlung von Erkrankungen im Zusammenhang mit Zellproliferation |
KR101235092B1 (ko) | 2004-08-14 | 2013-02-20 | 베링거 인겔하임 인터내셔날 게엠베하 | 저장 수명이 긴 디하이드로프테리디논 주입 용액 |
WO2006018220A3 (de) * | 2004-08-14 | 2006-10-12 | Boehringer Ingelheim Int | Verfahren zur herstellung von dihydropteridinonen |
CN101023070B (zh) * | 2004-08-14 | 2012-12-05 | 贝林格尔·英格海姆国际有限公司 | 制备二氢蝶啶酮的方法 |
US8138341B2 (en) | 2004-08-14 | 2012-03-20 | Boehringer Ingelheim International Gmbh | Intermediate compounds useful for the manufacture of dihydropteridinones |
US8138373B2 (en) | 2004-08-14 | 2012-03-20 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dihydropteridinones |
EP2409706A1 (de) | 2004-08-14 | 2012-01-25 | Boehringer Ingelheim International GmbH | Dihydropteridinone zur behandlung von krebserkrankungen |
WO2006018185A3 (en) * | 2004-08-14 | 2006-04-13 | Boehringer Ingelheim Int | Dihydropteridinones for the treatment of cancer diseases |
EA013820B1 (ru) * | 2004-08-14 | 2010-08-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Дигидроптеридиноны, способ их получения, промежуточные соединения |
WO2006018221A1 (de) * | 2004-08-14 | 2006-02-23 | Boehringer Ingelheim International Gmbh | Lagerstabile infusionslösung von dihydropteridinonen |
US8058270B2 (en) | 2004-08-14 | 2011-11-15 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
JP2008509952A (ja) * | 2004-08-14 | 2008-04-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 長い貯蔵寿命を有するジヒドロプテリジノン注入溶液 |
JP2008509948A (ja) * | 2004-08-14 | 2008-04-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 細胞増殖を伴う疾患の治療のための複合薬 |
JP2008509953A (ja) * | 2004-08-14 | 2008-04-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 4−[[(7r)−8−シクロペンチル−7−エチル−5,6,7,8−テトラヒドロ−5−メチル−4−6−オキソ−2−ピペリジニル]アミノ]−3−メトキシ−n−(1−メチル−4−ピペリジニル)ベンズアミドの水和物及び多形、その製造方法、並びにその薬物としての使用 |
JP2008509951A (ja) * | 2004-08-14 | 2008-04-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ジヒドロプテリジノンの製造方法 |
US7759485B2 (en) | 2004-08-14 | 2010-07-20 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dihydropteridinones |
WO2006018182A1 (en) * | 2004-08-14 | 2006-02-23 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
KR101258426B1 (ko) | 2004-08-14 | 2013-04-30 | 베링거 인겔하임 인터내셔날 게엠베하 | 세포 증식과 관련된 질환 치료용 배합물 |
WO2006018222A1 (de) * | 2004-08-14 | 2006-02-23 | Boehringer Ingelheim International Gmbh | Hydrate und polymorphe des 4-[[(7r)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-4-6-oxo-2-piperidinyl]amino]-3-methoxy-n-(1-methyl-4-piperidinyl)-benzamid, verfahren zu deren herstellung und deren verwendung als arzneimittel |
US7728134B2 (en) | 2004-08-14 | 2010-06-01 | Boehringer Ingelheim International Gmbh | Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament |
WO2006018220A2 (de) * | 2004-08-14 | 2006-02-23 | Boehringer Ingelheim International Gmbh | Verfahren zur herstellung von dihydropteridinonen |
EA014237B1 (ru) * | 2004-08-14 | 2010-10-29 | Бёрингер Ингельхайм Интернациональ Гмбх | Стабильный при хранении инфузионный раствор дигидроптеридинонов |
EP3560499A1 (de) | 2004-08-14 | 2019-10-30 | Boehringer Ingelheim International GmbH | Dihydropteridinone zur behandlung von krebserkrankungen |
US8445675B2 (en) | 2004-08-14 | 2013-05-21 | Boehringer Ingelheim International Gmbh | Storage stable perfusion solution for dihydropteridinones |
JP2012211178A (ja) * | 2004-08-14 | 2012-11-01 | Boehringer Ingelheim Internatl Gmbh | 癌疾患の治療のためのジヒドロプテリジノン |
EA011407B1 (ru) * | 2004-08-14 | 2009-02-27 | Бёрингер Ингельхайм Интернациональ Гмбх | Гидраты и полиморфы 4-[[(7r)-8-циклопентил-7-этил-5,6,7,8-тетрагидро-5-метил-6-оксо-2-птеридинил]амино]-3-метокси-n-(1-метил-4-пиперидинил)бензамида, способы их получения и их применение в качестве лекарственных средств |
EP2275107A2 (de) | 2004-08-14 | 2011-01-19 | Boehringer Ingelheim International GmbH | Kombinationen zur Behandlung von Erkrankungen im Zusammenhang mit Zellproliferation |
RU2521394C2 (ru) * | 2004-08-14 | 2014-06-27 | Бёрингер Ингельхайм Интернациональ Гмбх | Комбинации, предназначенные для лечения заболеваний, включающих пролиферацию клеток |
WO2006018185A2 (en) | 2004-08-14 | 2006-02-23 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
JP2012232990A (ja) * | 2004-08-14 | 2012-11-29 | Boehringer Ingelheim Internatl Gmbh | ジヒドロプテリジノンの製造方法 |
AU2005274384B2 (en) * | 2004-08-14 | 2011-06-23 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
KR101283378B1 (ko) * | 2004-08-14 | 2013-07-08 | 베링거 인겔하임 인터내셔날 게엠베하 | 암 질환의 치료를 위한 디하이드로프테리디논 |
US8591895B2 (en) | 2004-08-14 | 2013-11-26 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
KR101353990B1 (ko) * | 2004-08-14 | 2014-01-22 | 베링거 인겔하임 인터내셔날 게엠베하 | 암 질환의 치료를 위한 디하이드로프테리디논 |
AU2005274387B2 (en) * | 2004-08-14 | 2011-03-17 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
WO2006021378A1 (de) * | 2004-08-25 | 2006-03-02 | Boehringer Ingelheim International Gmbh | Dihydropteridinonderivate, verfahren zu deren herstellung und deren verwendung als arzneimittel |
US7807831B2 (en) | 2004-08-25 | 2010-10-05 | Boehringer Ingelheim International Gmbh | Dihydropteridione derivatives, process for their manufacture and their use as medicament |
US7332491B2 (en) | 2004-08-25 | 2008-02-19 | Boehringer Ingelheim International, Gmbh | Dihydropteridione derivatives, process for their manufacture and their use as medicament |
US7629460B2 (en) | 2004-08-25 | 2009-12-08 | Boehringer Ingelheim International Gmbh | Dihydropteridione derivatives, process for their manufacture and their use as medicament |
US7700769B2 (en) | 2004-08-25 | 2010-04-20 | Boehringer Ingelheim International Gmbh | Dihydropteridione derivatives, process for their manufacture and their use as medicament |
US7414053B2 (en) | 2004-08-25 | 2008-08-19 | Boehringer Ingelheim International Gmbh | Dihydropteridione derivatives, process for their manufacture and their use as medicament |
US7547780B2 (en) | 2004-08-25 | 2009-06-16 | Boehringer Ingelheim International Gmbh | Dihydropteridione intermediate compounds |
EP1632493A1 (de) * | 2004-08-25 | 2006-03-08 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
EP1630163A1 (de) * | 2004-08-25 | 2006-03-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
JP2008510751A (ja) * | 2004-08-25 | 2008-04-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ジヒドロプテリジノン誘導体、その製造方法及び薬物としての使用 |
US7723517B2 (en) | 2004-08-25 | 2010-05-25 | Boehringer Ingelheim International Gmbh | Dihydropteridione derivatives, process for their manufacture and their use as medicament |
WO2006021379A1 (de) * | 2004-08-25 | 2006-03-02 | Boehringer Ingelheim International Gmbh | Dihydropteridinonderivate, verfahren zu deren herstellung und deren verwendung als arzneimittel |
JP2008510771A (ja) * | 2004-08-27 | 2008-04-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ジヒドロプテリジノン、その製造方法および医薬薬剤としてのその使用 |
US7371753B2 (en) | 2004-08-27 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
WO2006021548A1 (de) * | 2004-08-27 | 2006-03-02 | Boehringer Ingelheim International Gmbh | Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel |
KR101395591B1 (ko) * | 2004-12-02 | 2014-05-16 | 베링거 인겔하임 인터내셔날 게엠베하 | 고리화된 피페라진-2-온 유도체의 제조 방법 및 상기 방법의 중간체 |
JP2008521861A (ja) * | 2004-12-02 | 2008-06-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 環付加ピペラジン−2−オン誘導体の製造方法及び前記方法の中間体 |
WO2006058876A1 (de) | 2004-12-02 | 2006-06-08 | Boehringer Ingelheim International Gmbh | Verfahren zur herstellung von annelierten piperazin-2-on derivaten sowie zwischenprodukte des verfahrens |
US7626019B2 (en) | 2004-12-02 | 2009-12-01 | Boehringer Ingelheim International Gmbh | Intermediate compounds for the manufacture of fused piperazin-2-one derivatives |
USRE43115E1 (en) | 2004-12-02 | 2012-01-17 | Boehringer Ingelheim International Gmbh | Process for the manufacture of fused piperazin-2-one derivatives |
EA012624B1 (ru) * | 2004-12-02 | 2009-10-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Способ получения аннелированных производных пиперазин-2-она и соответствующие промежуточные продукты |
KR101362131B1 (ko) * | 2004-12-02 | 2014-02-19 | 베링거 인겔하임 인터내셔날 게엠베하 | 고리화된 피페라진-2-온 유도체의 제조 방법 및 상기방법의 중간체 |
EP2436685A1 (de) | 2004-12-02 | 2012-04-04 | Boehringer Ingelheim International GmbH | Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten sowie Zwischenprodukte des Verfahrens |
US7238807B2 (en) | 2004-12-02 | 2007-07-03 | Boehringer Ingelheim International Gmbh | Process for the manufacture of fused piperazin-2-one derivatives |
WO2007014838A1 (en) * | 2005-08-03 | 2007-02-08 | Boehringer Ingelheim International Gmbh | Dihydropteridinones in the treatment of respiratory diseases |
EP2543669A2 (de) | 2006-02-08 | 2013-01-09 | Boehringer Ingelheim International GmbH | Trihydrochloridformen eines Dihydropteridionderivats und Verfahren zur Herstellung |
US7439358B2 (en) | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
EP2543669A3 (de) * | 2006-02-08 | 2013-05-15 | Boehringer Ingelheim International GmbH | Trihydrochloridformen eines Dihydropteridionderivats und Verfahren zur Herstellung |
KR101462879B1 (ko) | 2006-02-08 | 2014-11-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 디하이드로프테리디논 유도체의 트리하이드로클로라이드 형태 및 제조방법 |
EA015389B1 (ru) * | 2006-02-08 | 2011-08-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Тригидрохлорид производного дигидроптеридинона и способ его получения |
EA018663B1 (ru) * | 2006-02-08 | 2013-09-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Способ получения производного дигидроптеридинона |
WO2007090844A1 (en) * | 2006-02-08 | 2007-08-16 | Boehringer Ingelheim International Gmbh | Trihydrochloride forms of a dihydropteridinone derivative and processes for preparation |
US8188086B2 (en) | 2006-02-08 | 2012-05-29 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
US8664222B2 (en) | 2006-02-08 | 2014-03-04 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
US8022202B2 (en) | 2006-02-14 | 2011-09-20 | Vertex Pharmaceuticals Incorporated | Dihydrodiazepines useful as inhibitors of protein kinases |
US8394952B2 (en) | 2006-02-14 | 2013-03-12 | Vertex Pharmaceuticals Incorporated | Dihydrodiazepines useful as inhibitors of protein kinases |
US7622463B2 (en) | 2006-02-14 | 2009-11-24 | Vertex Pharmaceuticals Incorporated | Dihydrodiazepines useful as inhibitors of protein kinases |
WO2007135374A1 (en) * | 2006-05-19 | 2007-11-29 | Astrazeneca Ab | Dihydropteridine compounds as anti proliferative agents |
WO2008003958A2 (en) * | 2006-07-06 | 2008-01-10 | Astrazeneca Ab | Fused pyrimido compounds |
WO2008003958A3 (en) * | 2006-07-06 | 2008-03-06 | Astrazeneca Ab | Fused pyrimido compounds |
US7709471B2 (en) | 2006-07-06 | 2010-05-04 | Astrazeneca Ab | Compounds |
WO2008009909A1 (en) * | 2006-07-17 | 2008-01-24 | Astrazeneca Ab | Pteridimones as modulators of polo-like kinase |
WO2008040951A1 (en) * | 2006-10-03 | 2008-04-10 | Astrazeneca Ab | Compounds |
US8410100B2 (en) * | 2007-02-01 | 2013-04-02 | Boehringer Ingelheim International Gmbh | Pteridinone derivatives as PI3-kinases inhibitors |
US20100099680A1 (en) * | 2007-02-01 | 2010-04-22 | Boehringer Ingelheim International Gmbh | Pteridinone derivatives as p13-kinases inhibitors |
US7517873B2 (en) | 2007-03-22 | 2009-04-14 | Hoffman-La Roche Inc. | Substituted pyrimidodiazepines |
KR101157848B1 (ko) | 2007-03-22 | 2012-07-11 | 다케다 야쿠힌 고교 가부시키가이샤 | Plk1 저해제로서 유용한 치환된 피리미도디아제핀 |
JP2010521514A (ja) * | 2007-03-22 | 2010-06-24 | エフ.ホフマン−ラ ロシュ アーゲー | Plk1阻害剤として有用な置換ピリミドジアゼピン |
WO2008113711A1 (en) | 2007-03-22 | 2008-09-25 | F. Hoffmann-La Roche Ag | Substituted pyrimidodiazepines useful as plk1 inhibitors |
WO2008157235A1 (en) * | 2007-06-13 | 2008-12-24 | University Of Virginia Patent Foundation | Rsk inhibitors as anti-septicemia agents |
US8329695B2 (en) | 2007-08-03 | 2012-12-11 | Boehringer Ingelheim International Gmbh | Crystalline form of the free base N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7r)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide |
US8318727B2 (en) | 2007-09-25 | 2012-11-27 | Takeda Pharmaceutical Company Limited | Polo-like kinase inhibitors |
US8026234B2 (en) | 2007-09-25 | 2011-09-27 | Takeda Pharmaceutical Company Limited | Polo-like kinase inhibitors |
WO2009071480A3 (en) * | 2007-12-04 | 2009-11-05 | Nerviano Medical Sciences S.R.L. | Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors |
US8598172B2 (en) | 2007-12-04 | 2013-12-03 | Nerviano Medical Sciences S.R.L. | Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors |
WO2009071480A2 (en) * | 2007-12-04 | 2009-06-11 | Nerviano Medical Sciences S.R.L. | Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors |
WO2009111868A1 (en) | 2008-03-11 | 2009-09-17 | University Health Network | Method of treating cancer using a neuropeptide y 5r (np y5r) antagonist |
EP2100894A1 (de) | 2008-03-12 | 2009-09-16 | 4Sc Ag | Pyridopyrimidinone verwendbar als Plk1 (polo-like kinase) Hemmen |
EP2112152A1 (de) | 2008-04-22 | 2009-10-28 | GPC Biotech AG | Dihydropteridinones als Plk-Inhibitoren |
WO2009141575A1 (en) * | 2008-04-24 | 2009-11-26 | Chroma Therapeutics Ltd. | Inhibitors of plk |
US8093043B2 (en) | 2008-06-04 | 2012-01-10 | New York University | β-TrCP1, β-TrCP2 and RSK1 or RSK2 inhibitors and methods for sensitizing target cells to apoptosis |
US8003785B2 (en) | 2008-06-18 | 2011-08-23 | Takeda Pharmaceutical Company Limited | Halo-substituted pyrimidodiazepines |
US9127006B2 (en) | 2008-12-09 | 2015-09-08 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
US8809527B2 (en) | 2008-12-09 | 2014-08-19 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
US11110091B2 (en) | 2008-12-09 | 2021-09-07 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
US8629142B2 (en) | 2008-12-09 | 2014-01-14 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
US10172860B2 (en) | 2008-12-09 | 2019-01-08 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
US9452166B2 (en) | 2008-12-09 | 2016-09-27 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
US8367670B2 (en) | 2008-12-09 | 2013-02-05 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
US8476270B2 (en) | 2009-09-14 | 2013-07-02 | Gilead Sciences, Inc. | Dihydropyrido[4,3-b]pyrazine-3-ones as modulators of toll-like receptors |
US8691822B2 (en) | 2009-09-22 | 2014-04-08 | Jiangsu Hengrui Medicine Co., Ltd. | Dihydropteridinone derivatives, preparation process and pharmaceutical use thereof |
WO2011035534A1 (zh) | 2009-09-22 | 2011-03-31 | 江苏恒瑞医药股份有限公司 | 二氢喋啶酮类衍生物、其制备方法及其在医药上的应用 |
US8592577B2 (en) | 2009-09-25 | 2013-11-26 | Vertex Pharmaceuticals Incorporated | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors |
US8637666B2 (en) | 2009-09-25 | 2014-01-28 | Vertex Pharmaceuticals Incorporated | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors |
CN102548994A (zh) * | 2009-09-25 | 2012-07-04 | 沃泰克斯药物股份有限公司 | 用于制备用作蛋白激酶抑制剂的嘧啶衍生物的方法 |
EP2325185A1 (de) | 2009-10-28 | 2011-05-25 | GPC Biotech AG | Plk-Inhibitor |
US8541418B2 (en) | 2009-12-23 | 2013-09-24 | Elan Pharmaceutical, Inc. | Inhibitors of polo-like kinase |
WO2011079118A1 (en) | 2009-12-23 | 2011-06-30 | Elan Pharmaceuticals, Inc | Pteridinones as inhibitors of polo-like kinase |
WO2011079114A1 (en) | 2009-12-23 | 2011-06-30 | Elan Pharmaceuticals, Inc. | Pteridinones as inhibitors of polo - like kinase |
US8445503B2 (en) | 2009-12-23 | 2013-05-21 | Elan Pharmaceuticals, Inc. | Inhibitors of polo-like kinase |
WO2011101369A1 (en) | 2010-02-17 | 2011-08-25 | Boehringer Ingelheim International Gmbh | Dihydropteridinones, method for production and use thereof |
US8546566B2 (en) | 2010-10-12 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Process for manufacturing dihydropteridinones and intermediates thereof |
US9358233B2 (en) | 2010-11-29 | 2016-06-07 | Boehringer Ingelheim International Gmbh | Method for treating acute myeloid leukemia |
US9370535B2 (en) | 2011-05-17 | 2016-06-21 | Boehringer Ingelheim International Gmbh | Method for treatment of advanced solid tumors |
US9051269B2 (en) | 2011-11-18 | 2015-06-09 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
US9206128B2 (en) | 2011-11-18 | 2015-12-08 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
US9409865B2 (en) | 2011-11-18 | 2016-08-09 | Constellation_Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
US10016405B2 (en) | 2012-02-10 | 2018-07-10 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
US9371331B2 (en) | 2012-02-10 | 2016-06-21 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
US9085583B2 (en) | 2012-02-10 | 2015-07-21 | Constellation—Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
USRE47428E1 (en) | 2012-02-10 | 2019-06-11 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
US9980952B2 (en) | 2012-02-10 | 2018-05-29 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
US9469646B2 (en) | 2012-02-10 | 2016-10-18 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
US9006226B2 (en) | 2012-02-23 | 2015-04-14 | Boehringer Ingelheim International Gmbh | Dihydropteridinones I |
US8865716B2 (en) | 2012-02-23 | 2014-10-21 | Boehringer Ingelheim International Gmbh | Dihydropteridinones II |
WO2014127815A1 (en) * | 2013-02-21 | 2014-08-28 | Boehringer Ingelheim International Gmbh | Dihydropteridinones i |
WO2014127816A1 (en) * | 2013-02-21 | 2014-08-28 | Boehringer Ingelheim International Gmbh | Dihydropteridinones ii |
US9745305B2 (en) | 2013-03-15 | 2017-08-29 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
US9975896B2 (en) | 2013-07-25 | 2018-05-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcription factors and uses thereof |
US9956225B2 (en) | 2013-07-26 | 2018-05-01 | Boehringer Ingelheim International Gmbh | Treatment of myelodysplastic syndrome |
US9969716B2 (en) | 2013-08-15 | 2018-05-15 | Constellation Pharmaceuticals, Inc. | Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof |
US10150756B2 (en) | 2014-01-31 | 2018-12-11 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
US10730860B2 (en) | 2014-01-31 | 2020-08-04 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
US10793571B2 (en) | 2014-01-31 | 2020-10-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
WO2015193228A1 (de) * | 2014-06-19 | 2015-12-23 | Bayer Pharma Aktiengesellschaft | Bet-proteininhibitorische 1,4-dihydropyrido[3,4-b]pyrazinone mit para-substituierter aromatischer amino- oder ethergruppe |
WO2015193229A1 (de) * | 2014-06-19 | 2015-12-23 | Bayer Pharma Aktiengesellschaft | Bet-proteininhibitorische 1,4-dihydropyrido[3,4-b]pyrazinone mit meta-substituierter aromatischer amino- oder ethergruppe |
US11116774B2 (en) | 2014-07-11 | 2021-09-14 | Gilead Sciences, Inc. | Modulators of toll-like receptors for the treatment of HIV |
US10308653B2 (en) | 2014-08-08 | 2019-06-04 | Dana-Farber Cancer Institute, Inc. | Diazepane derivatives and uses thereof |
US9573952B2 (en) | 2014-09-16 | 2017-02-21 | Gilead Sciences, Inc. | Methods of preparing toll-like receptor modulators |
US11773098B2 (en) | 2014-09-16 | 2023-10-03 | Gilead Sciences, Inc. | Solid forms of a toll-like receptor modulator |
US10508117B2 (en) | 2014-09-16 | 2019-12-17 | Gilead Sciences, Inc. | Solid forms of a toll-like receptor modulator |
US10202384B2 (en) | 2014-09-16 | 2019-02-12 | Gilead Sciences, Inc. | Solid forms of a toll-like receptor modulator |
US11072615B2 (en) | 2014-09-16 | 2021-07-27 | Gilead Sciences, Inc. | Solid forms of a toll-like receptor modulator |
US9867831B2 (en) | 2014-10-01 | 2018-01-16 | Boehringer Ingelheim International Gmbh | Combination treatment of acute myeloid leukemia and myelodysplastic syndrome |
JP2021020957A (ja) * | 2014-12-23 | 2021-02-18 | ダナ−ファーバー キャンサー インスティテュート,インコーポレイテッド | 二官能性分子によって標的化タンパク質分解を誘導する方法 |
US10702527B2 (en) | 2015-06-12 | 2020-07-07 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
US10577350B2 (en) | 2015-08-28 | 2020-03-03 | Constellation Pharmaceuticals, Inc. | Crystalline forms of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide |
US11406645B2 (en) | 2015-09-11 | 2022-08-09 | Dana-Farber Cancer Institute, Inc. | Acetamide thienotriazolodiazepines and uses thereof |
US10881668B2 (en) | 2015-09-11 | 2021-01-05 | Dana-Farber Cancer Institute, Inc. | Acetamide thienotriazolodiazepines and uses thereof |
US11306105B2 (en) | 2015-09-11 | 2022-04-19 | Dana-Farber Cancer Institute, Inc. | Cyano thienotriazolodiazepines and uses thereof |
US10913752B2 (en) | 2015-11-25 | 2021-02-09 | Dana-Farber Cancer Institute, Inc. | Bivalent bromodomain inhibitors and uses thereof |
DE102017005089A1 (de) | 2016-05-30 | 2017-11-30 | Bayer Pharma Aktiengesellschaft | Substitulerte 3,4-Dihydrochinoxalin-2(1H)-one |
DE102017005091A1 (de) | 2016-05-30 | 2017-11-30 | Bayer Pharma Aktiengesellschaft | Substituierte 3,4-Dihydropyrido[2,3-b]pyrazin-2(1H)-one |
US10457640B2 (en) | 2016-10-19 | 2019-10-29 | Constellation Pharmaceuticals, Inc. | Synthesis of inhibitors of EZH2 |
US11059826B2 (en) | 2018-04-24 | 2021-07-13 | Vertex Pharmaceuticals Incorporated | Pteridinone compounds and uses thereof |
US11572364B2 (en) | 2018-04-24 | 2023-02-07 | Vertex Pharmaceuticals Incorporated | Pteridinone compounds and uses thereof |
AU2019257651B2 (en) * | 2018-04-24 | 2023-05-25 | Vertex Pharmaceuticals Incorporated | Pteridinone compounds and uses thereof |
IL278122B1 (en) * | 2018-04-24 | 2023-09-01 | Vertex Pharma | Petridinon compounds and their uses |
WO2019209757A1 (en) * | 2018-04-24 | 2019-10-31 | Vertex Pharmaceuticals Incorporated | Pteridinone compounds and uses thereof |
WO2020033823A1 (en) * | 2018-08-10 | 2020-02-13 | Yale University | Small-molecule pi5p4k alpha/beta inhibitors and methods of treatment using same |
EP3833353A4 (de) * | 2018-08-10 | 2022-08-24 | Yale University | Kleinmolekulare pi5p4k-alpha/beta-inhibitoren und verfahren zur behandlung damit |
US11773096B2 (en) | 2018-08-10 | 2023-10-03 | Yale University | Small-molecule PI5P4K alpha/beta inhibitors and methods of treatment using same |
EP3868762A4 (de) * | 2018-10-12 | 2022-06-29 | Hefei Institutes of Physical Science, Chinese Academy of Sciences | Mst1-kinasehemmer und verwendung davon |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1427730B1 (de) | Neue dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel | |
EP1599478B1 (de) | Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel | |
EP1761536B1 (de) | Neue 2-benzylaminodihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel | |
EP1776363B1 (de) | Neue 6-formyl-tetrahydropteridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel u.a. gegen krebs | |
US6806272B2 (en) | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions | |
EP1768981B1 (de) | Neue pyridodihydropyrazinone, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel | |
WO2006021378A1 (de) | Dihydropteridinonderivate, verfahren zu deren herstellung und deren verwendung als arzneimittel | |
WO2006021548A1 (de) | Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel | |
WO2006021547A1 (de) | Pteridinone als plk (polo like kinase) inhibitoren | |
EP0584487A2 (de) | Neue 4,5-Dihydro-4-oxo-pyrrolo (1,2-a) chinoxaline und entsprechende Aza-analoga und Verfahren zu deren Herstellung | |
EP0645390A1 (de) | Trisubstituierte Pyrimido/5,4-d/-pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung | |
DE19816857A1 (de) | Neue unsymmetrisch substituierte Xanthin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel | |
DE19629378A1 (de) | Neue Triazolopurine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel | |
DE602004004550T2 (de) | Substituierte heterocyclische verbindungen und anwendungsverfahren | |
DE60304327T2 (de) | 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINOi4,5-BöINDOLACETAMIDDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE THERAPEUTISCHE VERWENDUNG | |
EP1077950B1 (de) | Neue diphenyl-substituierte 6-ring heterocyclen, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel | |
EP0024582A1 (de) | Benzodiazepinone, Verfahren zu ihrer Herstellung sowie sie enthaltende Arzneimittel | |
DE10064778A1 (de) | Cyclisch substituierte Phenylamino-uracile | |
DE2410650A1 (de) | Neue heterocyclisch substituierte 4(1h)-pyrimidinon-verbindungen, verfahren zu ihrer herstellung und sie enthaltende arzneimittel | |
EP0042103A1 (de) | 7,8,9,10-Tetrahydrofuro(3,2-e)pyrido(4,3-b)indole, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln sowie deren Herstellung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: P-273/04 Country of ref document: YU |
|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG US UZ VC VN YU ZA ZM |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 160440 Country of ref document: IL |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2004/01365 Country of ref document: ZA Ref document number: 200401365 Country of ref document: ZA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2458699 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 00471/DELNP/2004 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1200400184 Country of ref document: VN |
|
WWE | Wipo information: entry into national phase |
Ref document number: P20040213A Country of ref document: HR Ref document number: 1-2004-500317 Country of ref document: PH Ref document number: PA/a/2004/002067 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003524992 Country of ref document: JP Ref document number: 20028172884 Country of ref document: CN Ref document number: 04020069 Country of ref document: CO Ref document number: 1020047003248 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 531928 Country of ref document: NZ Ref document number: 2002337047 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 200400368 Country of ref document: EA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002772249 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 2002772249 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 531928 Country of ref document: NZ |
|
WWG | Wipo information: grant in national office |
Ref document number: 531928 Country of ref document: NZ |
|
WWG | Wipo information: grant in national office |
Ref document number: 2002772249 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2002337047 Country of ref document: AU Date of ref document: 20020830 Kind code of ref document: B |
|
ENP | Entry into the national phase |
Ref document number: PI0212137 Country of ref document: BR Kind code of ref document: A2 Effective date: 20040225 |