WO2002000260A1 - Jp0105585atif contre des maladies du nerf optique et analogue - Google Patents
Jp0105585atif contre des maladies du nerf optique et analogue Download PDFInfo
- Publication number
- WO2002000260A1 WO2002000260A1 PCT/JP2001/005585 JP0105585W WO0200260A1 WO 2002000260 A1 WO2002000260 A1 WO 2002000260A1 JP 0105585 W JP0105585 W JP 0105585W WO 0200260 A1 WO0200260 A1 WO 0200260A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- retinal
- optic nerve
- diseases
- optic
- therapeutic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Definitions
- the present invention relates to optic nerve diseases in which 3-methyl-1-phenyl-1-2-virazoline-15-on or its acceptable salt as a drug is used as an active ingredient.
- Retinal circulation disorders such as retinal vein occlusion
- retinal circulation disorders such as retinal artery occlusion
- retinal disorder due to surgery or trauma d) c.
- the present invention relates to a therapeutic and / or prophylactic agent for retinal disorders caused by retinal disorders such as phenothiazine.
- neuronal cell death occurs in many optic nerve diseases.
- the mechanism that induces optic nerve cell death in optic nerve disease has not been fully elucidated, but is considered to be a factor in retinal ischemia.
- Ischemia is defined as a lack or lack of tissue blood circulation, and hypoxic pancreatia associated with a decrease in ocular blood flow due to increased intraocular pressure is thought to play an important role in optic nerve degeneration.
- glaucoma is currently being treated by reducing intraocular pressure with pharmacotherapy or surgery.
- a compound having a hydroxyradical-eliminating action for example, 3—methyl-1-phenyl-2—biazoline-5-one is used for cataract, retinopathy, etc. It has been shown that the onset or progression of eye disease can be prevented (Japanese Patent Application Laid-Open No. 7-257675). No reports have been made.
- Optic nerve disease etc., a) retinal circulation disorder such as retinal vein occlusion, b) retinal circulation disorder such as retinal artery occlusion, c) retinal disorder due to surgery or trauma, etc. d) disorders of the retina due to viruses, bacteria, fungi, etc., e) macular diseases such as age-related macular degeneration, f) degenerative diseases of the retina such as retinitis pigmentosa, g) retina. Exfoliation or h) Retinal dysfunction caused by retinal toxic drugs such as phenothiazine (hereinafter referred to as optic nerve disease) is a serious visual impairment, and there is no appropriate treatment. There is a need for a good therapeutic agent.
- the present invention aims to provide a new therapeutic and / or Z- or prophylactic agent for optic nerve diseases and the like.
- the present inventors have studied the mechanism of optic nerve and retinal neuronal cell death more deeply, and if a therapeutic method that suppresses cell death is developed, these intractable diseases can be treated.
- Dedicated research to improve the treatment results and to solve the above issues was implemented.
- compounds having a hydroxyradical-eliminating action, especially 3-methyl-1-phenyl-12-pyrazolin-15-on (hereinafter referred to as “MCI-18 6 j) or a salt that is acceptable as a drug has a protective effect on the optic nerve and is useful for the treatment of optic nerve diseases and the like.
- MCI-18 6 j 3-methyl-1-phenyl-12-pyrazolin-15-on
- the active ingredient is 3—methyl-1-phenyl-12—pyrazolin-15one or a salt thereof that is acceptable as a drug.
- a therapeutic and / or prophylactic agent for optic nerve disease or the like which is any of an oral preparation, an injection, an eye drop, an ointment, an ophthalmic suspension, and a sustained-release drug for optic nerve disease.
- optic nerve disease power s a) inflammatory diseases such as optic neuritis, b) circulatory diseases such as ischemic optic neuropathy, c) compression of the optic nerve due to surgery, trauma, tumors, etc.
- Optic nerve diseases are a) inflammatory diseases such as optic neuritis, b) diseases due to circulatory disorders such as ischemic optic neuropathy, c) optic nerve compression and edema due to surgery, trauma and tumors, etc. Damage to the optic nerve, d) toxic diseases of the optic nerve, such as ethanol or alcohol, e) optic nerve damage, such as in refractive surgery, and f) glaucoma. , Etc.
- the active ingredient of the drug of the present invention which is represented by MCI-186 or a salt thereof which is acceptable as a drug, is described in the above-mentioned Japanese Patent Publication No. 5-1828. It is a compound described in JP-A-15-223, and can be produced by the methods described in these publications or according to them.
- Salts acceptable as drugs include salts with mineral acids such as hydrochloric acid, sulfuric acid, hydrobromic acid, and phosphoric acid; methansulfonate, ⁇ -toluenesul Phosphoric acid, benzene / levonic acid, acetic acid, glyconoleic acid, glucuronic acid, maleic acid, fumaric acid, oxalic acid, azocorubic acid Salts with organic acids such as carboxylic acid, citric acid, salicylic acid, nicotinic acid, tartaric acid; Salts with alkaline metal such as sodium and potassium rim; Mag; Salts with alkaline earth metals such as nesium, calcium, etc .; ammonia, tris (hydroxymethyl) aminometan, N, N - bi scan (human mud key market shares chill) pin Pera di-down, 2 - A Mi Roh - 2 - main switch /, single-1 - profile Nono 0 node on Norre, error data node on
- MCI-186 or a salt thereof acceptable as a drug is clinically applied
- MCI-186 or a drug acceptable as a drug is acceptable.
- the salt is used as it is or as a pharmaceutical composition by mixing a carrier acceptable as a drug.
- a carrier acceptable as a drug When used as eye drops, 1 to 2 drops of the above compound l to 20 mg Z ml, 1 day:! It is preferable to apply it several times, and when it is used orally, the above compound:! ⁇ 100 mg / kg a day! It is preferable to administer the compound 0.01 to 3 times, and in the case of intravenous injection, 0.01 to 20 mg of the above compound is administered 2 to 5 times a day or these times.
- the above compound can be used by adding it to an intraocular perfusion solution.
- the above dosages may be used as appropriate, depending on age, condition, sex, symptoms, etc.
- the form of the pharmaceutical composition includes an aqueous eye drop, a non-aqueous eye drop, a suspension eye drop, an emulsion eye drop and the like in the case of eye drops.
- Ophthalmic preparations are manufactured using aqueous solvents such as sterile purified water, physiological saline, or non-aqueous solvents such as vegetable oils such as cottonseed oil, soybean oil, sesame oil, peanut oil, etc. 6 or by dissolving or suspending the pharmaceutically acceptable salt thereof.
- a tonicity agent, a pH adjusting agent, a thickening agent, a suspending agent, an emulsifier, a preservative, and the like may be appropriately added as necessary.
- Examples of the tonicity agent include sodium chloride, boric acid, sodium nitrate, potassium nitrate, D-mannitol, and glucose.
- pH regulators include boronic acid, sodium sulfite anhydride, hydrochloric acid, citric acid, sodium citrate, acetic acid, potassium acetate, and sodium carbonate.
- Um, borax, etc. are listed, and as the thickener, methylcellulose, hydroxypropinole methylenolose, polyvinylinole Alcohol, sodium chondroitin sulfate, polyvinylpyrrolidone, etc. can be fisted.
- Examples of the suspending agent include polysorenolate 80, polyoxyethylene hardened castor oil 60, and polyoxycane castor oil.
- Emulsifiers include egg yolk lecithin, polysorbate 80, etc., and preservatives include benzal konium chloride, benzone dium chloride, and chloroform. butanoate one Honoré, full et two Honoré et Chi Honoré a Honoré co over Honoré, Bruno, 0 etc. La Sai key sheet benzoic San'e scan Te le compound is exemplified et be.
- MCI-186 or a pharmaceutically acceptable salt thereof is usually used as a pharmaceutical carrier, that is, a composition containing excipients and other additives. It can be used as 'The carrier can be solid or liquid.
- Solid carriers include lactose, porcelain clay (kaolin), sucrose, crystal cell mouth, constarch, tar / rec, agar, zinc and aca. Examples include shea, stearic acid, magnesium stearate, lecithin, sodium chloride, etc., and the liquid carrier is syrup. , Glycerin, Peanut oil, Polyvinyl lipodon, Olive oil, Ethanore, Benzirua / Recohol, Propylene glycol , Water, etc.
- a solid carrier When a solid carrier is used, it can be in the form of tablets, powders, granules, hard gelatin capsules, suppositories, lozenges, and the like. At this time, the amount of the solid carrier is not limited, but it is preferably about 1 mg to about 1 g.
- a liquid carrier If a liquid carrier is used, use a syrup, emulsion, soft gelatin capsule, or a sterile injectable solution such as an ampoule or an aqueous or nonaqueous suspension. be able to .
- MCI-186 or a salt thereof which is acceptable as a drug is added to the cyclodextrin clathrate liposome. It is also preferable to release the drug by performing operations such as insertion.
- the drug for eye diseases of the present invention thus obtained is used as a drug for preventing or treating optic nerve disease and the like.
- saline or 3 mg / kg of MCI-186 was injected into the tail vein.
- the efficacy of this drug has been evaluated at the junction of ganglion cells with bipolar 'and amacrine cells, which are reported to cause marked degeneration (thinning) due to retinal ischemia.
- the measurement was performed by measuring the thickness of the retina including the inner plexiform layer.
- a retinal light microscope specimen 7 days after the treatment of ocular hypertension was prepared, and the thickness of the retina (the thickness of the inner reticular layer to the inner granular layer) was measured under a microscope using a ⁇ -meter. It was measured.
- Figure 1 shows the ratio of the retinal thickness between the untreated eye and the ocular hypertension treated eye after 7 days of ocular hypertension treatment in each group.
- Retinal thickness of untreated eye retinal thickness
- total thickness of inner plexiform layer to inner granular layer The value is the average value of each group, and the bar indicates the standard error.
- the number of cases was 10 in the control group and 11 in the MCI-186 group. * Indicates a significant difference (P ⁇ 0 ⁇ 01) from the control group Show.
- MCI-186 significantly suppressed retinal degeneration induced by transient retinal ischemia.
- the therapeutic and / or prophylactic agent for optic nerve disease and the like suppresses retinal degeneration induced by transient retinal ischemia, as a result of the inhibitory effect on retinal degeneration in transient ischemic eyes. Since it has an action, it has an effective therapeutic and / or preventive effect for optic nerve diseases and the like.
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001267864A AU2001267864A1 (en) | 2000-06-29 | 2001-06-28 | Remedial agent for optic nerve disease and the like |
CA002414586A CA2414586C (en) | 2000-06-29 | 2001-06-28 | Agent for therapeutic treatment of optic nerve diseases and the like |
EP01945674A EP1297849B1 (en) | 2000-06-29 | 2001-06-28 | Remedial agent for optic nerve diseases |
AT01945674T ATE428470T1 (de) | 2000-06-29 | 2001-06-28 | Heilmittel zur behandlung von erkrankungen des sehnervs |
DE60138385T DE60138385D1 (de) | 2000-06-29 | 2001-06-28 | Heilmittel zur behandlung von erkrankungen des sehnervs |
JP2002505041A JPWO2002000260A1 (ja) | 2000-06-29 | 2001-06-28 | 視神経疾患等治療剤 |
US11/477,854 US7638516B2 (en) | 2000-06-29 | 2006-06-30 | Agent for therapeutic treatment of optic nerve diseases and the like |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000-197250 | 2000-06-29 | ||
JP2000197250 | 2000-06-29 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10312502 A-371-Of-International | 2001-06-28 | ||
US11/477,854 Continuation US7638516B2 (en) | 2000-06-29 | 2006-06-30 | Agent for therapeutic treatment of optic nerve diseases and the like |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002000260A1 true WO2002000260A1 (fr) | 2002-01-03 |
Family
ID=18695597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2001/005585 WO2002000260A1 (fr) | 2000-06-29 | 2001-06-28 | Jp0105585atif contre des maladies du nerf optique et analogue |
Country Status (8)
Country | Link |
---|---|
US (2) | US20030109566A1 (ja) |
EP (1) | EP1297849B1 (ja) |
JP (1) | JPWO2002000260A1 (ja) |
AT (1) | ATE428470T1 (ja) |
AU (1) | AU2001267864A1 (ja) |
CA (1) | CA2414586C (ja) |
DE (1) | DE60138385D1 (ja) |
WO (1) | WO2002000260A1 (ja) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002092082A1 (en) * | 2001-05-11 | 2002-11-21 | Mitsubishi Pharma Corporation | Stable high-concentration injection containing pyrazolone derivative |
WO2004041270A1 (ja) * | 2002-11-05 | 2004-05-21 | Lead Chemical Co.,Ltd. | 3−メチル−1−フェニル−2−ピラゾリン−5−オン含有経皮吸収製剤 |
WO2007055312A1 (ja) * | 2005-11-10 | 2007-05-18 | Mitsubishi Tanabe Pharma Corporation | ピラゾロン化合物含有水溶液が充填されたプラスチック容器 |
WO2010087306A1 (ja) | 2009-01-29 | 2010-08-05 | 株式会社林原生物化学研究所 | 抗神経変性疾患剤 |
JP2011504177A (ja) * | 2007-11-21 | 2011-02-03 | テイコク ファーマ ユーエスエー インコーポレーテッド | ピラゾロン誘導体のエマルジョン製剤 |
US10004720B2 (en) | 2014-09-19 | 2018-06-26 | Mitsubishi Tanabe Pharma Corporation | Agent for preventing and/or treating ophthalmologic diseases |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA04011416A (es) | 2002-05-17 | 2005-09-30 | Othera Pharmaceuticals Inc | Mejora del desarrollo de las cataratas y otras enfermedades oftalmicas. |
US7825134B2 (en) | 2003-05-19 | 2010-11-02 | Othera Holding, Inc. | Amelioration of cataracts, macular degeneration and other ophthalmic diseases |
CN101102770A (zh) * | 2003-11-20 | 2008-01-09 | 奥特拉药物公司 | 白内障、黄斑变性和其它眼科疾病的改善 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0531523B2 (ja) | 1985-05-20 | 1993-05-12 | Mitsubishi Chem Ind | |
JPH0535128B2 (ja) | 1985-11-07 | 1993-05-25 | Mitsubishi Chem Ind | |
EP0609822A1 (en) * | 1993-02-02 | 1994-08-10 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition for preventing and treating retinal diseases |
EP0633025A1 (en) * | 1993-07-07 | 1995-01-11 | Mitsubishi Chemical Corporation | Pharmaceutical composition containing 3-methyl-1-phenyl-2-pyrazolin-5-one for the treatment of ophthalmological diseases |
JPH09278652A (ja) * | 1996-04-05 | 1997-10-28 | Sumitomo Pharmaceut Co Ltd | 網膜疾患治療剤 |
WO1998032863A2 (en) * | 1997-01-28 | 1998-07-30 | Karo Bio Ab | Mammalian thioredoxin |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3533662A1 (de) * | 1984-09-20 | 1986-03-27 | Medice Chem.-Pharm. Fabrik Pütter GmbH & Co KG, 5860 Iserlohn | Kombination von 1-phenyl-4-alkylpyrazolidindion-3,5-derivaten mit einem starken reduktionsmittel fuer die herstellung eines topischen entzuendungshemmenden arzneimittels fuer augen |
DK169672B1 (da) * | 1985-05-20 | 1995-01-09 | Mitsubishi Chem Ind | Farmaceutiske præparater indeholdende pyrazolonderivater som aktiv bestanddel og anvendelsen af pyrazolonderivater til fremstilling af farmaceutiske præparater |
FR2608045B1 (fr) | 1986-12-12 | 1990-03-02 | Chauvin Laboratoires | Utilisation d'inhibiteurs de xanthine- oxydase, de piegeurs de radicaux libres oxygenes et de chelateurs du fer pour la fabrication d'une composition pharmaceutique destinee au traitement du glaucome et compositions pharmaceutiques destinees au traitement du glaucome |
JP2906512B2 (ja) * | 1990-01-16 | 1999-06-21 | 三菱化学株式会社 | 抗潰瘍剤 |
WO1993000088A1 (de) * | 1991-06-24 | 1993-01-07 | Hoechst Aktiengesellschaft | Verwendung von phenylpyrazolin-derivaten zur behandlung von erhöhtem augeninnendruck |
JPH10218771A (ja) * | 1997-02-05 | 1998-08-18 | Ishihara Sangyo Kaisha Ltd | ピラゾロン系化合物またはその塩を含有する血小板由来血管内皮細胞増殖因子活性阻害剤 |
-
2001
- 2001-06-28 AT AT01945674T patent/ATE428470T1/de not_active IP Right Cessation
- 2001-06-28 AU AU2001267864A patent/AU2001267864A1/en not_active Abandoned
- 2001-06-28 JP JP2002505041A patent/JPWO2002000260A1/ja active Pending
- 2001-06-28 DE DE60138385T patent/DE60138385D1/de not_active Expired - Fee Related
- 2001-06-28 WO PCT/JP2001/005585 patent/WO2002000260A1/ja active Search and Examination
- 2001-06-28 US US10/312,502 patent/US20030109566A1/en not_active Abandoned
- 2001-06-28 EP EP01945674A patent/EP1297849B1/en not_active Expired - Lifetime
- 2001-06-28 CA CA002414586A patent/CA2414586C/en not_active Expired - Fee Related
-
2006
- 2006-06-30 US US11/477,854 patent/US7638516B2/en not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0531523B2 (ja) | 1985-05-20 | 1993-05-12 | Mitsubishi Chem Ind | |
JPH0535128B2 (ja) | 1985-11-07 | 1993-05-25 | Mitsubishi Chem Ind | |
EP0609822A1 (en) * | 1993-02-02 | 1994-08-10 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition for preventing and treating retinal diseases |
EP0633025A1 (en) * | 1993-07-07 | 1995-01-11 | Mitsubishi Chemical Corporation | Pharmaceutical composition containing 3-methyl-1-phenyl-2-pyrazolin-5-one for the treatment of ophthalmological diseases |
JPH09278652A (ja) * | 1996-04-05 | 1997-10-28 | Sumitomo Pharmaceut Co Ltd | 網膜疾患治療剤 |
WO1998032863A2 (en) * | 1997-01-28 | 1998-07-30 | Karo Bio Ab | Mammalian thioredoxin |
Non-Patent Citations (1)
Title |
---|
ROTH ET AL., CURRENT EYE RESEARCH, vol. 16, 1997, pages 875 - 885, XP002947215 * |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002092082A1 (en) * | 2001-05-11 | 2002-11-21 | Mitsubishi Pharma Corporation | Stable high-concentration injection containing pyrazolone derivative |
US7211596B2 (en) | 2001-05-11 | 2007-05-01 | Mitsubishi Pharma Corporation | Stable high-concentration injection containing pyrazolone derivative |
WO2004041270A1 (ja) * | 2002-11-05 | 2004-05-21 | Lead Chemical Co.,Ltd. | 3−メチル−1−フェニル−2−ピラゾリン−5−オン含有経皮吸収製剤 |
CN100372531C (zh) * | 2002-11-05 | 2008-03-05 | 立德化学株式会社 | 含有3-甲基-1-苯基-2-吡唑啉-5-酮的透皮吸收制剂 |
WO2007055312A1 (ja) * | 2005-11-10 | 2007-05-18 | Mitsubishi Tanabe Pharma Corporation | ピラゾロン化合物含有水溶液が充填されたプラスチック容器 |
JPWO2007055312A1 (ja) * | 2005-11-10 | 2009-04-30 | 田辺三菱製薬株式会社 | ピラゾロン化合物含有水溶液が充填されたプラスチック容器 |
JP5973118B2 (ja) * | 2005-11-10 | 2016-08-23 | 田辺三菱製薬株式会社 | ピラゾロン化合物含有水溶液が充填されたプラスチック容器 |
JP2011504177A (ja) * | 2007-11-21 | 2011-02-03 | テイコク ファーマ ユーエスエー インコーポレーテッド | ピラゾロン誘導体のエマルジョン製剤 |
WO2010087306A1 (ja) | 2009-01-29 | 2010-08-05 | 株式会社林原生物化学研究所 | 抗神経変性疾患剤 |
US10004720B2 (en) | 2014-09-19 | 2018-06-26 | Mitsubishi Tanabe Pharma Corporation | Agent for preventing and/or treating ophthalmologic diseases |
Also Published As
Publication number | Publication date |
---|---|
CA2414586A1 (en) | 2002-12-30 |
EP1297849B1 (en) | 2009-04-15 |
AU2001267864A1 (en) | 2002-01-08 |
DE60138385D1 (de) | 2009-05-28 |
EP1297849A4 (en) | 2006-10-18 |
JPWO2002000260A1 (ja) | 2004-01-08 |
US7638516B2 (en) | 2009-12-29 |
US20030109566A1 (en) | 2003-06-12 |
CA2414586C (en) | 2009-09-29 |
ATE428470T1 (de) | 2009-05-15 |
EP1297849A1 (en) | 2003-04-02 |
US20060247293A1 (en) | 2006-11-02 |
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