WO2001076605A1 - Preparations a base de minoxidil - Google Patents

Preparations a base de minoxidil Download PDF

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Publication number
WO2001076605A1
WO2001076605A1 PCT/JP2001/002951 JP0102951W WO0176605A1 WO 2001076605 A1 WO2001076605 A1 WO 2001076605A1 JP 0102951 W JP0102951 W JP 0102951W WO 0176605 A1 WO0176605 A1 WO 0176605A1
Authority
WO
WIPO (PCT)
Prior art keywords
minoxidil
containing composition
antioxidant
composition according
ginger
Prior art date
Application number
PCT/JP2001/002951
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
Koji Imamura
Rumi Ochiai
Takako Okajima
Susumu Morioka
Taro Horie
Original Assignee
Taisho Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NZ521733A priority Critical patent/NZ521733A/en
Priority to EP01919789A priority patent/EP1273299B1/en
Priority to AT01919789T priority patent/ATE306925T1/de
Priority to US10/240,856 priority patent/US20030157046A1/en
Priority to AU46839/01A priority patent/AU778783B2/en
Priority to DE60114171T priority patent/DE60114171T2/de
Application filed by Taisho Pharmaceutical Co., Ltd. filed Critical Taisho Pharmaceutical Co., Ltd.
Priority to CA002405429A priority patent/CA2405429C/en
Priority to BR0109847-0A priority patent/BR0109847A/pt
Priority to HU0301124A priority patent/HUP0301124A2/hu
Publication of WO2001076605A1 publication Critical patent/WO2001076605A1/ja
Priority to JP2002102373A priority patent/JP4796260B2/ja
Priority to HK03108884A priority patent/HK1056510A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00Preparations for affecting hair growth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/347Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4966Triazines or their condensed derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • A61K8/553Phospholipids, e.g. lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/676Ascorbic acid, i.e. vitamin C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52Stabilizers
    • A61K2800/522Antioxidants; Radical scavengers

Definitions

  • the present invention relates to a minoxidil-containing composition that prevents coloring over time.
  • Minoxidil is a component that is expected as an external hair restorer because of its hair restorer effect.
  • An object of the present invention is to prevent coloring of a composition containing minoxidil. Disclosure of the invention
  • a colored screening ingredient to a liquid formulation by adding an antioxidant such as dibutylhydroxytoluene.
  • an antioxidant such as dibutylhydroxytoluene can be used for a liquid formulation containing minoxidil.
  • the present inventors have found that the addition of an oxidizing agent hardly contributes to the prevention of coloring, or enhances rather than prevents coloring.
  • the present invention is a minoxidil-containing composition containing an antioxidant and having a pH of 5.5 to 7.0.
  • the present invention is also a minoxidil-containing composition containing diptylhydroxytoluene or butylhydroxyanisole and having a pH of 5.5 to 7.0.
  • the present invention is also a method for preventing discoloration of a minoxidil-containing composition, wherein an antioxidant is added to the composition and the pH is adjusted to 5.5 to 7.0.
  • the antioxidants used in the present invention include dibutylhydroxytoluene, butylhydroxyanisole, erythorbic acid, EDTA-2Na, isopropyl citrate, propyl gallate, guaiac acid, alphathioglycerin, dichlor From potassium isocyanurate, 2,6-di-butyl-4-methylphenol, soybean lecithin, sodium thioglycolate, sodium thiomalate, ascorbyl palmitate, 2-mercaptobenzimidazole, oxyquinoline sulfate One or two selected from the group described below are preferred.
  • Crude drug extracts can also be used as antioxidants, especially flea, ginger, ginger, ginger, ginger, ginger, ginger, ginger, ginger, ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger, ginger ginger.
  • an alcohol having 2 to 4 carbon atoms eg, ethanol, propylene glycol, 1,3-butylene glycol, glycerin, etc.
  • a mixed solvent thereof eg., ethanol, propylene glycol, 1,3-butylene glycol, glycerin, etc.
  • the compounding amount of the antioxidant in the present composition is preferably from 0.05 to 0.5 part by mass, more preferably from 0.01 to 0.5 part by mass, per 1 part by mass of minoxidil.
  • coloring may be enhanced even when the pH is in the range of 5.5 to 7.0 when a sufficient amount is not added.
  • the pH of the composition of the present invention is preferably 5.5 or more, and more preferably 5.7 or more, since lowering the pH lowers the coloring prevention effect.
  • pH is preferably 7.0 or less, more preferably 6.3 or less, from the viewpoint of the solubility of minoxidil.
  • the pH of the composition of the present invention can be adjusted using a pH adjusting agent that is commonly used.
  • a pH adjusting agent that is commonly used.
  • organic acids such as citric acid, malic acid and lactic acid, phosphoric acid, hydrochloric acid, Inorganic acids such as sulfuric acid can be mentioned.
  • the concentration of minoxidil is preferably from 1 to 10% by mass, more preferably from 3 to 6% by mass of the whole composition.
  • a polyhydric alcohol as a solvent.
  • Polyhydric alcohols include propylene glycol, dipropylene glycol, 1,3-butylene glycol glycerin, hexylene glycolone, and polyethylene glycol are preferred, and 1,3-butylene glycol is more preferred.
  • the blending amount of the polyhydric alcohol is preferably 1 to 50 parts by mass per 1 part by mass of minoxidil.
  • composition of the present invention is not particularly limited, and can be any of lotions, aerosols, genoles, and the like. Can be prepared by any suitable method.
  • composition of the present invention may contain, if necessary, a solubilizer (fatty acid ester, polyhydric alcohol fatty acid ester, medium-chain fatty acid glyceride, vegetable oil, alkyl glyceryl ether), surfactant (nonionic surfactant) , Lecithin derivatives, polymer emulsifiers), emulsion stabilizers, absorption promoters and the like.
  • a solubilizer fatty acid ester, polyhydric alcohol fatty acid ester, medium-chain fatty acid glyceride, vegetable oil, alkyl glyceryl ether
  • surfactant nonionic surfactant
  • Lecithin derivatives emulsifiers
  • emulsion stabilizers emulsion stabilizers
  • absorption promoters emulsion stabilizers and the like.
  • ⁇ ⁇ ⁇ ⁇ was measured with a glass electrode: ⁇ was measured after 5 minutes for 5 mL of the preparation using a ⁇ meter (manufactured by Toa Denpa Kogyo).
  • a lotion-type composition was prepared.
  • the pH of the composition was 6.0.
  • Minoxidil 5 g, propylene glycol 52 g, ethanol 25 g, dibutylhydroxytoluene 0.5 g, phosphoric acid 0.3 mL are added, the total volume is made up to 100 mL with purified water, and the mixture is stirred and dissolved to give a lotion type.
  • the pH of the composition was 6.0.
  • Minoxidil (5 g), propylene glycol (52 g), and ethanol (25 g) were added, and the total amount was adjusted to 10 OmL with purified water, followed by stirring and dissolution to prepare a lotion-type composition.
  • the pH of the composition was 8.7.
  • the appearance was evaluated according to the following criteria.
  • Comparative Example 1 coloring was recognized, and it was judged that there was a problem with the merchantability. However, in the case of the yarns of Examples 1 to 4, no coloring was observed, or slight coloring was observed. It was judged that there was no problem as a product.
  • Example 5 Each of the compositions of Example 5 and Comparative Examples 2 to 4 was filled in a pet container, and 50. .
  • the absorbance (420 nm) of the sample stored for 1 month at was measured using an absorption altimeter (manufactured by Beckman).
  • Comparative Example 2 and Comparative Example 3 show that the minoxidil yarn composition further enhances coloring by decreasing the pH. Further, the results of Comparative Example 4 show that the addition of BHT enhances the coloring rather than preventing the coloring. On the other hand, in Example 5, a better coloring prevention effect was obtained than in any of the comparative examples.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
PCT/JP2001/002951 2000-04-07 2001-04-05 Preparations a base de minoxidil WO2001076605A1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EP01919789A EP1273299B1 (en) 2000-04-07 2001-04-05 Minoxidil-containing preparations
AT01919789T ATE306925T1 (de) 2000-04-07 2001-04-05 Minoxidil enthaltende zubereitung
US10/240,856 US20030157046A1 (en) 2000-04-07 2001-04-05 Minoxidil-containing preparations
AU46839/01A AU778783B2 (en) 2000-04-07 2001-04-05 Minoxidil-containing preparations
DE60114171T DE60114171T2 (de) 2000-04-07 2001-04-05 Minoxidil enthaltende zubereitung
NZ521733A NZ521733A (en) 2000-04-07 2001-04-05 Minoxidil-containing preparations
CA002405429A CA2405429C (en) 2000-04-07 2001-04-05 Minoxidil-containing preparation
BR0109847-0A BR0109847A (pt) 2000-04-07 2001-04-05 Composição contendo minoxidila, e, método para impedir a coloração da mesma
HU0301124A HUP0301124A2 (hu) 2000-04-07 2001-04-05 Elszíneződésre nem hajlamos. minoxidil-tartalmú kompozíció és eljárás minoxidiltartalmú kompozíció elszíneződésének megakadályozására
JP2002102373A JP4796260B2 (ja) 2001-04-05 2002-04-04 ミノキシジル含有製剤
HK03108884A HK1056510A1 (en) 2000-04-07 2003-12-05 Minoxidil-containing preparations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000-107028 2000-04-07
JP2000107028A JP4780429B2 (ja) 2000-04-07 2000-04-07 ミノキシジル含有製剤

Publications (1)

Publication Number Publication Date
WO2001076605A1 true WO2001076605A1 (fr) 2001-10-18

Family

ID=18620086

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/002951 WO2001076605A1 (fr) 2000-04-07 2001-04-05 Preparations a base de minoxidil

Country Status (18)

Country Link
EP (1) EP1273299B1 (es)
JP (1) JP4780429B2 (es)
KR (1) KR100740393B1 (es)
CN (1) CN1279914C (es)
AT (1) ATE306925T1 (es)
AU (1) AU778783B2 (es)
BR (1) BR0109847A (es)
CA (1) CA2405429C (es)
DE (1) DE60114171T2 (es)
DK (1) DK1273299T3 (es)
ES (1) ES2250374T3 (es)
HK (1) HK1056510A1 (es)
HU (1) HUP0301124A2 (es)
NZ (1) NZ521733A (es)
RU (1) RU2275914C2 (es)
TW (1) TWI239842B (es)
WO (1) WO2001076605A1 (es)
ZA (1) ZA200207960B (es)

Cited By (2)

* Cited by examiner, † Cited by third party
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US6946120B2 (en) 1998-04-22 2005-09-20 Connetics Australia Pty. Ltd. Pharmaceutical composition
US8026238B2 (en) 1997-10-17 2011-09-27 Stiefel Research Australia, Pty Ltd Topical antifungal composition

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JP5785353B2 (ja) * 2004-02-27 2015-09-30 大正製薬株式会社 眼科用剤
TW200534875A (en) * 2004-04-23 2005-11-01 Lonza Ag Personal care compositions and concentrates for making the same
JP2006022091A (ja) * 2004-06-09 2006-01-26 Dai Ichi Seiyaku Co Ltd 育毛用組成物
JP5040060B2 (ja) * 2004-10-14 2012-10-03 大正製薬株式会社 メチオニン配合内服液剤
AU2007335379B2 (en) * 2006-12-20 2012-06-14 Taisho Pharmaceutical Co., Ltd. Prophylactic or therapeutic agent for alopecia
US20090175810A1 (en) 2008-01-03 2009-07-09 Gareth Winckle Compositions and methods for treating diseases of the nail
JP5286999B2 (ja) * 2008-07-10 2013-09-11 大正製薬株式会社 ミノキシジル含有液剤
JP2012504135A (ja) 2008-09-27 2012-02-16 ジャイナ ファーマシューティカルズ,インコーポレーテッド 経口適用および局所適用のための脂質系薬学的調製物、ならびにそれらの組成物、方法、および使用
US8470833B2 (en) 2009-12-15 2013-06-25 Mcneil-Ppc, Inc. Hair growth and/or regrowth compositions
US8039494B1 (en) 2010-07-08 2011-10-18 Dow Pharmaceutical Sciences, Inc. Compositions and methods for treating diseases of the nail
EP2952194B1 (en) * 2013-01-31 2018-06-27 Fujifilm Corporation Emulsion composition
JP6199066B2 (ja) * 2013-04-24 2017-09-20 ロート製薬株式会社 ミノキシジル含有外用組成物
KR101580119B1 (ko) * 2013-04-29 2015-12-29 한국유나이티드제약 주식회사 쓴맛이 차폐된 황련 추출물을 포함하는 경구투여용 제제
MY179756A (en) 2013-10-03 2020-11-12 Dow Pharmaceutical Sciences Stabilized efinaconazole formulations
CN105848719A (zh) 2013-11-22 2016-08-10 道尔医药科学公司 抗感染的方法、组合物和装置
JP6736889B2 (ja) * 2015-01-23 2020-08-05 大正製薬株式会社 外用組成物
JP6528194B2 (ja) * 2015-02-06 2019-06-12 ダイヤ製薬株式会社 ミノキシジル含有外用液剤および外用液剤の製造方法
JP6052686B2 (ja) * 2015-02-06 2016-12-27 ダイヤ製薬株式会社 外用液剤
JP6825354B2 (ja) * 2015-12-29 2021-02-03 大正製薬株式会社 外用組成物
JP7346010B2 (ja) * 2016-09-15 2023-09-19 大正製薬株式会社 外用組成物
KR102000217B1 (ko) * 2017-08-08 2019-07-15 에스씨엠생명과학 주식회사 Cxcl1 단백질 및 미녹시딜을 유효성분으로 포함하는 탈모 예방 또는 치료용 약학적 조성물
JP2017206558A (ja) * 2017-08-22 2017-11-24 ロート製薬株式会社 ミノキシジル含有外用組成物
JP2020023467A (ja) * 2018-01-19 2020-02-13 ロート製薬株式会社 外用製剤、液切れ性を改善する方法、および、液切れ性改善剤
JP7304463B2 (ja) * 2018-01-29 2023-07-06 富士化学工業株式会社 ミノキシジル含有外用組成物
JP2019014764A (ja) * 2018-11-06 2019-01-31 ロート製薬株式会社 ミノキシジル含有外用組成物

Citations (3)

* Cited by examiner, † Cited by third party
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US8026238B2 (en) 1997-10-17 2011-09-27 Stiefel Research Australia, Pty Ltd Topical antifungal composition
US8586066B2 (en) 1997-10-17 2013-11-19 Delcor Asset Corporation Topical antifungal composition
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AU778783B2 (en) 2004-12-23
CN1279914C (zh) 2006-10-18
NZ521733A (en) 2003-08-29
EP1273299A1 (en) 2003-01-08
JP4780429B2 (ja) 2011-09-28
KR20020087126A (ko) 2002-11-21
DE60114171D1 (de) 2006-03-02
HUP0301124A2 (hu) 2003-08-28
EP1273299A4 (en) 2003-05-14
ATE306925T1 (de) 2005-11-15
TWI239842B (en) 2005-09-21
CA2405429A1 (en) 2001-10-18
BR0109847A (pt) 2003-06-24
KR100740393B1 (ko) 2007-07-16
DK1273299T3 (da) 2006-02-06
AU4683901A (en) 2001-10-23
CA2405429C (en) 2007-09-04
CN1431903A (zh) 2003-07-23
EP1273299B1 (en) 2005-10-19
ZA200207960B (en) 2004-01-27
RU2002126553A (ru) 2004-03-20
HK1056510A1 (en) 2004-02-20
RU2275914C2 (ru) 2006-05-10
ES2250374T3 (es) 2006-04-16
DE60114171T2 (de) 2006-07-06

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