Classifications

• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
  • B65D51/00—Closures not otherwise provided for
  • B65D51/18—Arrangements of closures with protective outer cap-like covers or of two or more co-operating closures
  • B65D51/20—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing
  • B65D51/22—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure
  • B65D51/221—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being left inside the container after the opening
  • B65D51/226—Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing having means for piercing, cutting, or tearing the inner closure a major part of the inner closure being left inside the container after the opening the piercing or cutting means being non integral with, or not fixedly attached to, the outer closure
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
  • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
  • A61J1/14—Details; Accessories therefor
  • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
  • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
  • B65D51/00—Closures not otherwise provided for
  • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
  • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
  • A61J1/14—Details; Accessories therefor
  • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
  • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
  • A61J1/2006—Piercing means
  • A61J1/201—Piercing means having one piercing end
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
  • B65D2251/00—Details relating to container closures
  • B65D2251/0003—Two or more closures
  • B65D2251/0006—Upper closure
  • B65D2251/0015—Upper closure of the 41-type
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
  • B65D2251/00—Details relating to container closures
  • B65D2251/0003—Two or more closures
  • B65D2251/0037—Intermediate closure(s)
  • B65D2251/0056—Intermediate closure(s) of the 47-type
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
  • B65D2251/00—Details relating to container closures
  • B65D2251/0003—Two or more closures
  • B65D2251/0068—Lower closure
  • B65D2251/009—Lower closure of the 51-type

Definitions

• the invention relates to a connection device between a closed container and a container.
• the invention also relates to a ready-to-use assembly comprising, inter alia,
• connection devices each comprising a base adapted to cover the neck of a container
• the invention more particularly intends to remedy by proposing a connection device in which the piston is effectively guided in its translational movement between the above positions while the cost price of the entire device can be significantly reduced compared to that of known devices.
• the invention relates to a connection device between a closed container and a container, this container comprising a neck, the opening of which is closed by a sleeve while the connection device comprises a base, capable of being mounted on the container and comprising a sleeve forming an internal bore, and a piston capable of sliding in this bore, between a -draft position released relative to this plug and a second position, called transfer, in which a hollow needle carried by or constituting the piston passes through this plug.
• This device is characterized in that the piston and the base are formed in one piece and connected by at least one elastic tongue able to deform, essentially in a direction parallel to a central axis of the bore, to accompany the movement of the piston between the above positions.
• the base and the piston can be molded in a single operation, which makes it possible to optimize the manufacturing range of the device of the invention and to reduce the cost thereof.
• the elastic tab (s) determine the intensity of the effort that a user must apply to move the piston and the needle between the first and the second position, this effort being able to be relatively unimportant, which facilitates its use by the personnel. medical.
• the piston is much easier to move than in the case where it is connected to the base by one or more breakable tabs, the rupture of which could require significant effort.
• the tab (s) of the device of the invention which essentially deform according to the direction of translation of the piston, do not deform in a dimension which would allow rotation of the piston. This is why these tongues also constitute means for guiding in translation, without rotation, the piston between these two positions.
• the device incorporates one or more of the following characteristics:
• the tab (s) have a width, measured in a direction generally parallel to a radial surface of the bore, substantially greater than their thickness, measured in a direction generally perpendicular to this surface.
• This geometry of the tongues makes it possible to give them good torsional rigidity, so that they effectively oppose a rotation of the piston around the central axis of the bore.
• the tab (s) thus have rigidity. in sufficient torsion to guide the piston in translation, without significant rotation, in the bore.
• the tab or tabs form two bearing zones against an internal radial surface of the bore and against an external radial surface of the piston.
• the base carries elastic snap-fastening means on the neck of the container, a hooping ring of these means in the snapped-in position on this neck being provided around these means, this ring being formed in one piece with a cap of protection of the base, while a continuous breakable zone connects this ring and this cap.
• This breakable zone is advantageously formed by a liquid and gas tight membrane, so that it effectively protects the base against microbial pollution during the storage of a container equipped with a device in accordance with
• liquid and gas tight is meant that the membrane is tight at the pressures that usually supports such a device, especially during storage.
• the base includes support means on the external surface of the plug around the hollow needle, the diameter of these means being slightly greater than the diameter of this needle.
• These means thus make it possible to avoid bulging of the plug during its drilling and to guide, if necessary, the needle during drilling.
• these means consist of a sleeve forming the part of the bore closest to the plug, the edge of this sleeve intended to be pressed against the plug having a profile allowing a surface penetration of this edge in the outer surface of the cap.
• a confined volume, of relatively small diameter is thus created around the piston and inside the bore, this volume limiting the quantity of product liable to be lost due to a leak between the needle or the needle. and the plug in particular " in the case where the needle is not pressed into the plug in a direction strictly parallel to the central axis of the bore.
• the invention also relates to a ready-to-use assembly
• a ready-to-use assembly comprising a closed container containing a product, in particular a pharmaceutical preparation, this container being provided with a neck whose opening is closed by a plug, and a connection device such as previously described mounted on the container.
• a connection device such as previously described mounted on the container.
• FIG. 1 is an exploded side view of a ready to use assembly according to the invention and a syringe provided to cooperate with this assembly;
• - Figure 2 is an axial section of the device mounted on the assembly of Figure 1, in storage configuration
• - Figure 3 is a perspective view with partial cutaway of the part forming a base of the device of Figure and
• Figure 4 is a section similar to Figure 2 while the device is in the transfer configuration.
• the device 1 has a double function. On the one hand, it ensures the inviolability of a container 2, for example a glass bottle, containing a product which is not shown and which has previously been closed or capped.
• This product can be a powder intended to form an oral vaccine. It can be any other type of pharmaceutical preparation, in particular any type of drug.
• the device 1 also makes it possible to ensure or establish a sealed connection between the interior of the container 2 and the interior of another container, such as a syringe 3 containing a liquid intended to dissolve or in suspension the product contained in the container 2.
• a syringe 3 containing a liquid intended to dissolve or in suspension the product contained in the container 2.
• the container 3 could be formed by a flexible pouch, another glass vial or any other container.
• the bottle 2 has a neck 4, the opening 4a of which is sealed off by a plug 5 made of a relatively soft material, for example an elastomer, in particular rubber.
• a capsule can be arranged around the plug 5 and an external annular part 4b of the neck 4, this capsule being provided with a central opening through which it is possible to perforate the plug. 5.
• the plug 5 has a substantially cylindrical central part 5a, suitable for a flexible and tight fitting inside the opening 4a, and a flattened part 5b, supported on the part 4b and possibly covered by the capsule.
• the device 1 is essentially formed of two parts produced by injecting plastic material, for example polyethylene and / or polypropylene, namely a base element or base 10, intended to be mounted around elements 4 and 5, and an external envelope 40.
• the base 10 comprises a cylindrical part 11 intended to be centered on the axis XX 'of symmetry of the elements 2, 4 and 5.
• This part 11 comprises a lower north 11a having in cross section a pointed profile intended to penetrate superficially in the upper or exposed surface 5c of the plug 5.
• the part 11 is extended by several elastic tabs 12 each equipped with a spout 13 capable of cooperating with the external surface of the neck 4 for the purpose of an elastic snap-fastening of the base 10 on the neck.
• the base 10 is provided with teeth 14 forming a rotational locking device of the base 10 relative to the plug 5 with lecuel teeth 14 are n ⁇ s ⁇ .
• the base 10 carries a second series of teeth 16.
• the part 11 is extended by an annular strip 17 of junction with a sleeve 18 which forms an internal bore A for storage and displacement of a piston 19 constituted by a hollow needle.
• the internal radial surface 20 of the sleeve 18 is generally cylindrical and centered on the axis XX 'which is thus the central axis of the bore A, while its external surface 21 is slightly frustoconical and that it carries two doubly chamfered ears - born 22 and 22 'allowing it to cooperate with a system for fixing the syringe 3 of the "LUER-LOCK" type by means of a nut 6 for mounting the syringe 3 on the base 10.
• connection between the syringe 3 and the nut 6 can be obtained by clipping or by the fact that the nut 6 is an integral part of the syringe 3.
• the hollow needle 19 forms a central channel 23 and three openings 24, two of which appear in FIGS. 2 and 4, near its tapered tip 25.
• the sleeve 18 and the needle 19 are connected by three elastic tongues 26, so that the elements 11 to 26 form a single piece constituting the base 10.
• the tongues 26 have a width 1, measured parallel to the surface 20 or to the external radial surface 27 of the needle 19, much greater than their thickness e which is measured perpendicular to the surfaces 20 and 27.
• the tongues 26 can deform in a direction parallel to the axis XX 'but have relatively high rigidity in rotation about the axis XX'.
• the width 1 . is at least five times the thickness e.
• the edge 18a of the sleeve 18 which is opposite the flange 2 has, like the edge 11a, a pointed profile allowing it to penetrate superficially in the surface 5c of the plug 5, a hollow volume 28 being defined between the part of the sleeve 18 la *, read close to the plug 5 and the cylindrical n ** ⁇ rti6 11.
• the envelope 40 is also monobloc and comprises a ring 41 serving as a hoop for the legs 12 when the spouts 13 are in place under the part 4b of the neck 4.
• the ring 41 is bordered by an internal collar 41a for locking under the spouts 13
• This ring 41 is extended by a second ring 42 of slightly smaller diameter and which more specifically surrounds the part 11 of the base 10.
• the envelope 40 is provided with teeth 44 intended to cooperate with the teeth 16 of the base 10 in order to allow immobilization in rotation of the envelope 40 relative to the base 10.
• the ring 42 On its internal radial surface, the ring 42 carries three ribs 45, centered on the axis XX 'and perpendicular thereto, intended to create a sealed assembly, without interposition of seal, between the base 10 and the casing 40
• the assembly between the base 10 and the casing 40 is tight as long as the ring 42 carries at least one rib of the type of ribs 45.
• the exact number of ribs which may be less than or greater than three, depends on design choice.
• a cap 46 is an integral part of the envelope 40 and is connected to an upper edge of the ring 42 by a continuous breakable zone 47 of small thickness.
• the area 47 can have a thickness of between 0.5 and 1 tenth of a millimeter.
• a device 1 is mounted on a container 2 in the configuration of FIGS. 2 and 3 for a relatively long period, during the storage of the product contained in the container 2.
• the cap 46 is removed by exerting on it a rotational movement R which has the effect of tearing the zone 47 since the elements 10 to 45 are immobilized in rotation around the neck 4.
• each tongue 26 has one end 29 secured to the piston 19 distant from a distance d relative to the surface 5ç_ while its end 30 secured to the surface 20 is distant from a distance d ' relative to the same surface 5ç.
• the distance d is greater than the distance d 'in the configuration of FIGS. 2 and 3.
• the distance d is less than the distance d' which remains constant. In other words, the end 29 of each tongue 26 is approached to the plug 5 during the translation of the needle or piston 19 corresponding to the perforation of the plug 5.
• the tongues 26 form two bearing zones 31 and 32, respectively against the surfaces 27 and 20, so that the progression of the needle 19 towards the interior volume of the container 2 is blocked in this configuration.
• the tongues 26 can constitute a stop for the displacement of the needle 19 during the perforation of the plug 5.
• the edge 18a of the sleeve 18 is permanently in firm support against the plug 5, which avoids any bulging effect of the plug due to a creep of its constituent material.
• the surface penetration of the edge 18a into the surface 5c_ guarantees a seal between the volume 50, defined inside the sleeve 18 around the needle 19 and between the plug 5 and the hole 3a of the syringe 3, and the volume 28.
• the dead volume 50 constitutes the volume in which part of the liquid from the container 2 could flow due to a leak between the needle 19 and the stopper 5.
• the maximum loss of active liquid is confined to this volume 50 which can be relatively small due to the small difference in diameter between the surfaces 20 and 27
• the elasticity of the tabs 26 can be chosen, so that their configuration shown at FIG. 4 is a stable configuration in the sense that the needle 19 does not tend to rise towards the outlet of the sleeve 18 fitted with the flange 22, including after removal of the end 3a.

Landscapes

• Engineering & Computer Science (AREA)
• Mechanical Engineering (AREA)
• Health & Medical Sciences (AREA)
• Pharmacology & Pharmacy (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Infusion, Injection, And Reservoir Apparatuses (AREA)
• Medical Preparation Storing Or Oral Administration Devices (AREA)
• Closures For Containers (AREA)

Priority Applications (12)

Applications Claiming Priority (2)

Publications (1)

Family

ID=9552020

Family Applications (1)

Country Status (23)

Cited By (53)

Families Citing this family (33)

Citations (5)

• 1999
  • 1999-11-05 FR FR9914197A patent/FR2800713B1/fr not_active Expired - Fee Related
• 2000
  • 2000-10-26 TW TW89122519A patent/TW482670B/zh not_active IP Right Cessation
  • 2000-11-02 JP JP2001534690A patent/JP4582983B2/ja not_active Expired - Fee Related
  • 2000-11-02 KR KR1020027005815A patent/KR100726297B1/ko not_active Expired - Fee Related
  • 2000-11-02 EP EP00974636A patent/EP1226077B1/fr not_active Expired - Lifetime
  • 2000-11-02 AU AU12863/01A patent/AU761176B2/en not_active Ceased
  • 2000-11-02 HK HK03100210.1A patent/HK1048293A1/zh unknown
  • 2000-11-02 DE DE2000604082 patent/DE60004082T2/de not_active Expired - Lifetime
  • 2000-11-02 CN CNB008144796A patent/CN1214955C/zh not_active Expired - Fee Related
  • 2000-11-02 DK DK00974636T patent/DK1226077T3/da active
  • 2000-11-02 PT PT00974636T patent/PT1226077E/pt unknown
  • 2000-11-02 HU HU0203945A patent/HUP0203945A3/hu not_active Application Discontinuation
  • 2000-11-02 RU RU2002114693A patent/RU2230693C2/ru not_active IP Right Cessation
  • 2000-11-02 MX MXPA02004526A patent/MXPA02004526A/es active IP Right Grant
  • 2000-11-02 ES ES00974636T patent/ES2202187T3/es not_active Expired - Lifetime
  • 2000-11-02 CA CA 2386830 patent/CA2386830C/en not_active Expired - Fee Related
  • 2000-11-02 CO CO00083592A patent/CO5420204A1/es not_active Application Discontinuation
  • 2000-11-02 WO PCT/FR2000/003057 patent/WO2001032524A1/fr not_active Ceased
  • 2000-11-02 PL PL00357270A patent/PL357270A1/xx unknown
  • 2000-11-02 BR BR0015268A patent/BR0015268A/pt not_active Application Discontinuation
  • 2000-11-02 AT AT00974636T patent/ATE245581T1/de not_active IP Right Cessation
  • 2000-11-03 AR ARP000105806 patent/AR026357A1/es active IP Right Grant
• 2002
  • 2002-04-04 ZA ZA200202627A patent/ZA200202627B/en unknown
• 2010
  • 2010-05-25 JP JP2010119921A patent/JP2010207610A/ja not_active Withdrawn

Patent Citations (5)

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