WO2001010852A1 - Process for the preparation of thiazole derivatives - Google Patents
Process for the preparation of thiazole derivatives Download PDFInfo
- Publication number
- WO2001010852A1 WO2001010852A1 PCT/EP2000/007709 EP0007709W WO0110852A1 WO 2001010852 A1 WO2001010852 A1 WO 2001010852A1 EP 0007709 W EP0007709 W EP 0007709W WO 0110852 A1 WO0110852 A1 WO 0110852A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acid
- chloride
- formula
- hydroxymethylthiazole
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/50—Nitrogen atoms bound to hetero atoms
Definitions
- the present invention relates to intermediate thiazole compounds and a process for preparing 2-chloro-5-chloromethyl-thiazole which is a known compound useful for the preparation of insecticides.
- the compound 2-chloro-5-chloromethyl-thiazole is known intermediate useful for the preparation of insecticides. See European patent application No. 192,060.
- U.S. Patent 4,748,243 to Beck et al. and EP 448,913 describe a process of preparing 2-chlo- ro-5-chloromethyl-thiazole by reaction certain allyl isocyanates with chlorine.
- 2-chloro-5-chloromethylthiazole may be conveniently prepared from 2-chloro-5-hydroxymethylthiazole, 2-hydroxy-5- hydroxymethylthiazole or a 5-hydroxymethylthiazol-2-diazonium salt compound. These processes avoid the costs and hazards of using allyl isocyanate reagents and chlorine. Additionally, it has been discovered that 2-chloro-5-hydroxymethylthiazole and 2-hy- droxy-5-hydroxymethylthiazole may be prepared via a 5-hydroxymethylthiazol-2-dia- zonium intermediate.
- the 2-chloro-5-hy- droxymethylthiazole, the 2-hydroxy-5-hydroxymethylthiazole or the 5-hydroxymethyl- thiazol-2-diazonium salts may be derived from 2-amino-5-hydroxymethylthiazole which is a known compound.
- One embodiment of the invention is the compound 2-hydroxy-5-hydroxymethyl- thiazole having the formula:
- salts 2-hydroxy-5-hydroxymethylthiazole are also similarly useful intermediates and are part of the instantly disclosed invention.
- hydrochloride salts of 2-chloro-5-hydroxymethylthiazole and 2-hydroxy-5-hydroxy- methylthiazole also are useful intermediates for preparing 2-chloro-5-chloromethyl- thiazole.
- Another embodiment of the invention is 5-hydroxymethylthiazolyl-2-diazonium salt of formula:
- a " is a counter-anion derived from an acid HA, wherein HA is an organic acid or inorganic mineral acid.
- the organic acid for example may be formic acid, acetic acid, or benzoic acid.
- the inorganic acid for example may be a halogen acid, sulfuric acid, nitric acid, or phosphoric acid.
- a " is a halogen anion, an anion of the formula OSO 2 R ⁇ wherein R is C C 4 alkyl, phenyl, C 7 -C 10 -alkyl- aryl, or C 5 -C 10 cycloalkyl; or an anion of the formula OOC-R 2 wherein R 2 is alkyl or R
- the diazonium salts are useful for making 2-chloro-5-hydroxymethyl- thiazole, 2-hydroxy-5-hydroxymethylthiazole and 2-chloro-5-chloromethylthiazole.
- Another embodiment of the invention is the process for making 2-chloro-5- chloromethylthiazole (and acid addition salts thereof) comprising the step of reacting the known 2-chloro-5-hydroxymethylthiazole, or 2-hydroxy-5-hydroxymethylthiazole or a 5-hydroxymethylthiazolyl-2-diazonium salt with a chloride anion source in the presence of an acid.
- the chloride anion source is not limited to but may be selected from the group consisting of an inorganic acid, a chloride salt, an acyl chloride and a sulfonyl chloride.
- the inorganic acid acting as the chloride anion source for example may be HCI, SOCI 2 , PCI 3 , POCI 3 , or PCI 5 .
- the chloride salt may be for example NaCI, KCI , CaCI 2l ammonium chloride or a mono-, di-, tri-, tetra-alkylammonium chloride.
- the acyl chloride for example may be acetyl chloride or benzoyl chloride; or for example a chloroformate or a thiochloroformate such as ethyl chloroformate or ethyl thiochloro- formate.
- the sulfonyl chloride for example may be mesyl chloride or tosyl chloride.
- the starting reagent is a hydrochloride addition salt or is 5-hy- droxymethylthiazolyl-2-diazonium chloride salt
- the starting reagent itself will serve also as a chloride anion source.
- the presence of acid in the reaction medium may be generated in situ from the reaction of the appropriate chloride anion source with the 2-chloro-5-hydroxymethylthiazole, 2-hydroxy-5-hydroxymethylthiazole or any hydroxylic solvent that may be present in the reaction medium.
- the presence of acid in the reaction medium may also be provided by the addition of an organic acid or an inorganic acid.
- the organic acid for example may be formic acid, acetic acid, or benzoic acid.
- the inorganic acid for example may be a halogen acid, sulfuric acid, nitric acid, sulfur trioxide, phosphoric acid or phosphorous pentoxide.
- the process may preferably be conducted in the presence of a solvent.
- the solvent for example may be hexane, cyclohexane, chloroform, methylene chloride, di- ethyl ether, tetrahydrofuran, toluene, or water, or mixtures thereof. When water is present other by-products may result due to the hydrolysis.
- the process may also be advantageously conducted under reflux conditions.
- Another embodiment of the invention is the process for making 2-chloro-5- hydroxymethylthiazole (and acid addition salts thereof) comprising the step of reacting 2-amino-5-hydroxymethylthiazole (and acid addition salts thereof) with an alkali metal nitrite in the presence of an acid and in the presence of a chloride anion source.
- the alkali metal nitrite may be either sodium nitrite or potassium nitrite.
- the presence of a chloride anion source may be obtained by addition of the chloride anion source described above.
- the presence of acid in the reaction medium may be achieved in a similar fashion as discussed above for preparing 2-chloro-5-chloromethylthiazole.
- 2-chloro-5-chloromethylthiazoIe may be prepared directly from 2-amino-5-hydroxymethylthiazole without isolating or purifying the intermediate 2-chloro-5-hydroxymethylthiazole.
- Another embodiment of the invention is the process for making 2-chloro-5- hydroxymethylthiazole (and acid addition salts thereof) comprising the step of reacting a 5-hydroxymethylthiazolyl-2-diazonium salt with a chloride anion source in the presence of an acid.
- the reaction conditions regarding the chloride anion source and the presence of acid are the same or similar to those used for the preparation of 2-chloro-5- chloromethylthiazole discussed above. It will be recognized that when the 5-hydroxy- methylthiazolyl-2-diazonium chloride salt (or hydrochloride salt thereof) is used it will serve also as a chloride anion source.
- Another embodiment of the invention is the process for making 2-hydroxy-5- hydroxymethylthiazole (and acid addition salts thereof) comprising the step of reacting 2-amino-5-hydroxymethylthiazole (and acid addition salts thereof) with an alkali metal nitrite in the presence of water.
- the alkali metal nitrite may be either sodium nitrite or potassium nitrite.
- the presence of a water may be obtained by addition of water or the water may be carried into the reaction from the previous reaction step(s) for preparing the 2-amino-5-hydroxymethylthiazole.
- Another embodiment of the invention is the process for making 2-hydroxy-5- hydroxymethylthiazole (and acid addition salts thereof) comprising the step of reacting a 5-hydroxymethylthiazolyl-2-diazonium salt with water.
- Another embodiment of the invention is the process for making the 5-hydroxy- methylthiazolyl-2-diazonium salt of formula (1) (and acid addition salts thereof) comprising the step of reacting 2-amino-5-hydroxymethylthiazole with an alkali metal nitrite in the presence of acid.
- the alkali metal nitrite may be either sodium nitrite or potassium nitrite.
- the presence of acid in the reaction medium may be achieved in a similar fashion as discussed above for preparing 2-chloro-5-chloromethylthiazole.
- 2-chloro-5-chloromethylthiazole may be prepared directly from 2- amino-5-hydroxymethylthiazole without isolating or purifying the intermediate a 5-hy- droxymethylthiazolyl-2-diazonium salt.
- the 5-hydroxy- methylthiazolyl-2-diazonium chloride salt (or hydrochloride salt thereof) may serve also as a chloride anion source.
- Another aspect of the invention is the product produced from the process of diazotizing 2-amino-5-hydroxythiazole (and addition salts thereof) with aqueous alkali metal nitrite.
- the 5-hydroxymethylthiazolyl-2-diazonium salt of formula (1) or the product from the process of diazotization (to the extent there is a difference) are both features of the instantly disclosed invention.
- the scope of the invention as to the diazonium salts and the process of preparing the compound of formula (1) disclosed herein should not be construed to be limited by any particular chemical theory relating to the complexation, equilibration, reaction or acid-base chemistry of the components used to make the diazonium salt or the final product.
- Another aspect of the invention is a 5-hydroxymethylthiazolyl-2-diazonium salt of formula (1) wherein said salt has interacted chemically so as to result in a changed form of the salt or has interacted with other chemical components so as to form another more stable compound or acid addition salt thereof.
- the present invention encompasses the substantially unaltered static composition of the appropriate components as well as the chemically integrated composition.
- Static composition denotes 1) the composition composed of components wherein the components have not substantially changed by virtue of their combination or interaction with other composition components, or 2) the composition that has reacted to a point of relative stasis.
- “Chemically integrated composition” means a composition that results from any equilibration, complexation, dissociation or other chemical transformation (if any) that may occur after combination of the reagents used to prepare the product composition containing the salts of formula (1) and prior to ultimate use for the preparation of 2-chloro-5-hydroxymethylthiazole, 2-chloro-5-chloromethyIthiazole and 2-hydroxy-5-hydroxymethylthiazole. Therefore, the "chemically integrated composition” of the instant invention by definition encompasses the situation where there is an unchanged “static composition” as well as the equilibrated or semi- equilibrated composition existing at any point between initial creation and ultimate use. In other words, the disclosed invention relating to diazonium salts is not limited to a static composition of chemically unaltered constituent components.
- Another embodiment of the invention is the process for making 2-amino-5- hydroxymethylthiazole (and acid addition salts thereof) comprising the step of reacting epoxypropanal with thiourea, preferably in an aqueous solvent system.
- the epoxy- propanal is a known compound and may be prepared for example by reacting acrolein with an epoxidizing agent, preferably in an aqueous solvent system.
- the peroxides that are suitable epoxidizing agents are known and include hydrogen peroxide, alkylhydro- peroxides, dialkylperoxides, peracids and peracid anhydrides. Examples of peracids include peracetic acid and perbenzoic acid.
- Another aspect of the instant invention is the preparation of 2-amino-5- hydroxythiazole directly from acrolein by reaction with a peroxide followed by reaction with thiourea, without isolating or purifying the intermediate epoxypropanal.
- the reaction is preferably conducted under aqueous solvent conditions.
- addition salts are meant salts of a given compound (or salt) of the invention derived from the chemical interaction with inorganic acids or organic acids. Acid addition salts may also be adducts with an organic solvent or water.
- Examples of acid addition salts derived from inorganic acids include hydro- chlorides, hydrobromides, hydroiodides, sulfates, hydrogensulfates, phosphates, monohydrogenphosphates, dihydrogenphosphates, nitrates, and thiocyanates.
- Examples of acid addition salts derived from organic acids include carboxylates, sulfo- nates, and phosphonates.
- Examples of acid addition salts derived from a carboxylic acid include formates, acetates, propionates, butyrates, cinnamates, benzoates, lac- tates, oxalates, malonates, succinates, glutarates, adipates, maleates, fumarates, phthalates, citrates, tartarates, salicylates, nicotinates, mandelates and salts from amino acids.
- Examples of acid addition salts derived from a sulfonic acid include alkyl- sulfonates (e.g. methanesulfonates, benzenesulfonates (e.g.
- acid addition salts derived from a phosphonic acid include alkylphosphonates (e.g. methylphosphonates) and benzenephosphonates (e.g. phenylphosphonates).
- alkyl is meant a C C 10 alkyl group which is linear or branched.
- suitable alkyl groups include methyl, ethyl, n-propyl, iso-propyl, n- butyl, iso-butyl, sec- butyl, tert-butyl, neo-pentyl, n-hexyl, n-octyl and n-decyl.
- Scheme I Synthetic scheme for preparing 2-chloro-5- chloromethylthiazole.
- a solution of 800 ml water and 118 g. of 30% hydrogen peroxide (1.04 mole) was adjusted to a pH of 8.0-8.5 and cooled to 10°C. While maintaining a pH of 8-8.5 and a temperature of 10-20°C, 56 g (1.00 mole) of acrolein is added dropwise.
- the aqueous solution of the epoxy propanal must be kept cold until it is used directly to make 2-amino-5-hydroxymethylthiazole.
- the product may also be isolated using known procedures.
- a reactor vessel is charged with 2-amino-2-hydroxymethylthiazole (1.0 moles, in a concentrated hydrochloric acid solution).
- the solution is cooled to 0°C and sodium nitrite (1.1 equiv., in a concentrated hydrochloric acid solution) is added drop-wise to the reactor vessel with vigorous agitation of the reaction while maintaining the temperature in the range 0°C to 20°C.
- the reaction medium is maintained at 0°C with stirring for 3 hours. Excess nitrous acid is then quenched by addition of urea.
- the product 5-hydroxymethylthiazole-2-diazonium salt may be isolated using known extraction and solvent removal procedures or the reaction product may be used directly to prepare 2-chloro-5-hydroxylmethylthiazole, 2-hydroxy-5-hydro- xylmethylthiazole or 2-chloro-5-chloromethylthiazole.
- a 1.00 mole batch of 2-amino-5-hydroxymethylthiazole was prepared in water as described above in Example 2. The water was removed by rotory evaporation, and the residue was dissolved in 500 ml. of concentrated HCI. The solution was cooled to between -5 and 5°C, then 1.00 mole of sodium nitrite was added in portions. The temperature of the reaction solution increased to 11°C after an exotherm. The solution was then allowed to stir for 2 hours. Twenty grams of urea was added, followed by 50 ml of concentrated nitric acid. The solution was cooled to 0°C and 8 g of copper metal was added and the solution was stirred overnight. The mixture was extracted 3 times with methybutylketone. The solvent was removed by rotary evaporation to yield an oil (18 g.) that was identified by GC MS as 2-chloro-5-chloromethylthiazole.
- this invention provides new intermediates that are useful for preparing the 2-chloro-5-ch!oromethylthiazole which is an intermediate that is known to be useful for preparing insecticides.
- the invention also encompasses the processes for making the intermediates used to make 2-chloro-5-chloromethylthiazole. Variations may be made in proportions, procedures and materials without departing from the scope of the invention as defined by the following claims.
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00956412A EP1202979B1 (en) | 1999-08-10 | 2000-08-08 | Process for the preparation of thiazole derivatives |
KR1020027001623A KR20020022796A (ko) | 1999-08-10 | 2000-08-08 | 티아졸 유도체의 제조방법 |
DE60019763T DE60019763D1 (de) | 1999-08-10 | 2000-08-08 | Verfahren zur herstellung von thiazolderivaten |
AT00956412T ATE294166T1 (de) | 1999-08-10 | 2000-08-08 | Verfahren zur herstellung von thiazolderivaten |
JP2001515318A JP2003506444A (ja) | 1999-08-10 | 2000-08-08 | チアゾール誘導体の製法 |
AU68364/00A AU778367B2 (en) | 1999-08-10 | 2000-08-08 | Process for the preparation of thiazole derivatives |
US10/049,073 US6476230B1 (en) | 1999-08-10 | 2000-08-08 | Process for the preparation of thiazole derivatives |
MXPA02001246A MXPA02001246A (es) | 1999-08-10 | 2000-08-08 | Proceso para la preparacion de derivados de tiazol. |
CA002380838A CA2380838A1 (en) | 1999-08-10 | 2000-08-08 | Process for the preparation of thiazole derivatives |
BR0013235-7A BR0013235A (pt) | 1999-08-10 | 2000-08-08 | Processo para a preparação de derivados de tiazol |
HU0202819A HUP0202819A3 (en) | 1999-08-10 | 2000-08-08 | Process for the preparation of thiazole derivatives and the new intermediates |
US10/431,100 US6710182B2 (en) | 1999-08-10 | 2003-05-07 | Process for the preparation of thiazole derivatives |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/371,180 US6265553B1 (en) | 1999-08-10 | 1999-08-10 | Intermediate thiazoles and process for the preparation of 2-chloro-5-chloromethyl-thiazole |
US09/371,180 | 1999-08-10 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/371,180 Division US6265553B1 (en) | 1999-08-10 | 1999-08-10 | Intermediate thiazoles and process for the preparation of 2-chloro-5-chloromethyl-thiazole |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/049,073 A-371-Of-International US6476230B1 (en) | 1999-08-10 | 2000-08-08 | Process for the preparation of thiazole derivatives |
US10/244,236 Division US6566530B2 (en) | 1999-08-10 | 2002-09-16 | Process for the preparation of thiazole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001010852A1 true WO2001010852A1 (en) | 2001-02-15 |
Family
ID=23462834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2000/007709 WO2001010852A1 (en) | 1999-08-10 | 2000-08-08 | Process for the preparation of thiazole derivatives |
Country Status (19)
Country | Link |
---|---|
US (4) | US6265553B1 (xx) |
EP (1) | EP1202979B1 (xx) |
JP (1) | JP2003506444A (xx) |
KR (1) | KR20020022796A (xx) |
CN (2) | CN1169800C (xx) |
AR (1) | AR030258A1 (xx) |
AT (1) | ATE294166T1 (xx) |
AU (1) | AU778367B2 (xx) |
BR (1) | BR0013235A (xx) |
CA (1) | CA2380838A1 (xx) |
CZ (1) | CZ2002483A3 (xx) |
DE (1) | DE60019763D1 (xx) |
ES (1) | ES2238029T3 (xx) |
HU (1) | HUP0202819A3 (xx) |
MX (1) | MXPA02001246A (xx) |
RU (1) | RU2002105516A (xx) |
TR (2) | TR200202474T2 (xx) |
WO (1) | WO2001010852A1 (xx) |
ZA (1) | ZA200201110B (xx) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2537124C (en) | 2003-08-29 | 2012-08-07 | Mitsui Chemicals, Inc. | Agricultural/horticultural insecticide and method for using the same |
CN102762544B (zh) * | 2010-02-17 | 2016-03-30 | 先正达参股股份有限公司 | 作为杀虫剂的异噁唑啉衍生物 |
KR20130036206A (ko) * | 2010-02-26 | 2013-04-11 | 스미또모 가가꾸 가부시키가이샤 | 사이클로프로판카르본산 에스테르 화합물의 제조 방법 |
US20150164069A1 (en) * | 2011-09-01 | 2015-06-18 | Biotelliga Holdings Limited | Insecticidal lipid agents isolated from entomopathogenic fungi and uses thereof |
CN106749086B (zh) * | 2016-12-27 | 2019-05-24 | 江苏振方生物化学有限公司 | 一种农药中间体2-氯-5-氯甲基噻唑的制备方法 |
CN111036158A (zh) * | 2019-12-28 | 2020-04-21 | 邯郸市瑞田农药有限公司 | 一种2氯-5氯甲基噻唑合成反应系统 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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EP0775700A1 (en) * | 1995-11-22 | 1997-05-28 | Kureha Chemical Industry Co., Ltd. | Process for the replacement of a primary amino group by a chlorine atom and utilization of this process for the preparation of 2-chloro-5-chloromethyl-thiazol |
WO1998032747A1 (en) * | 1997-01-22 | 1998-07-30 | Novartis Ag | Process for the preparation of thiazole derivatives |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3631538A1 (de) * | 1986-09-17 | 1988-03-24 | Bayer Ag | Verfahren zur herstellung von 2-chlor-5-chlormethylthiazol |
US5773625A (en) * | 1997-10-02 | 1998-06-30 | Abbott Laboratories | Process for the preparation of disubstituted carbonates |
US6407251B1 (en) * | 2000-12-28 | 2002-06-18 | Takeda Chemical Industries, Ltd. | Process for preparing 2-chloro-5-chloromethylthiazole |
-
1999
- 1999-08-10 US US09/371,180 patent/US6265553B1/en not_active Expired - Fee Related
-
2000
- 2000-08-08 CZ CZ2002483A patent/CZ2002483A3/cs unknown
- 2000-08-08 BR BR0013235-7A patent/BR0013235A/pt not_active IP Right Cessation
- 2000-08-08 ES ES00956412T patent/ES2238029T3/es not_active Expired - Lifetime
- 2000-08-08 CN CNB008114455A patent/CN1169800C/zh not_active Expired - Fee Related
- 2000-08-08 EP EP00956412A patent/EP1202979B1/en not_active Expired - Lifetime
- 2000-08-08 AT AT00956412T patent/ATE294166T1/de not_active IP Right Cessation
- 2000-08-08 WO PCT/EP2000/007709 patent/WO2001010852A1/en active Search and Examination
- 2000-08-08 RU RU2002105516/04A patent/RU2002105516A/ru not_active Application Discontinuation
- 2000-08-08 US US10/049,073 patent/US6476230B1/en not_active Expired - Fee Related
- 2000-08-08 MX MXPA02001246A patent/MXPA02001246A/es unknown
- 2000-08-08 HU HU0202819A patent/HUP0202819A3/hu not_active Application Discontinuation
- 2000-08-08 AU AU68364/00A patent/AU778367B2/en not_active Ceased
- 2000-08-08 CN CNA2004100566415A patent/CN1626525A/zh active Pending
- 2000-08-08 TR TR2002/02474T patent/TR200202474T2/xx unknown
- 2000-08-08 JP JP2001515318A patent/JP2003506444A/ja active Pending
- 2000-08-08 AR ARP000104086A patent/AR030258A1/es not_active Application Discontinuation
- 2000-08-08 CA CA002380838A patent/CA2380838A1/en not_active Abandoned
- 2000-08-08 DE DE60019763T patent/DE60019763D1/de not_active Expired - Lifetime
- 2000-08-08 TR TR2002/00304T patent/TR200200304T2/xx unknown
- 2000-08-08 KR KR1020027001623A patent/KR20020022796A/ko not_active Application Discontinuation
-
2002
- 2002-02-08 ZA ZA200201110A patent/ZA200201110B/en unknown
- 2002-09-16 US US10/244,236 patent/US6566530B2/en not_active Expired - Fee Related
-
2003
- 2003-05-07 US US10/431,100 patent/US6710182B2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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Also Published As
Publication number | Publication date |
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ES2238029T3 (es) | 2005-08-16 |
TR200200304T2 (tr) | 2002-06-21 |
ZA200201110B (en) | 2002-11-27 |
EP1202979A1 (en) | 2002-05-08 |
US6710182B2 (en) | 2004-03-23 |
KR20020022796A (ko) | 2002-03-27 |
CN1626525A (zh) | 2005-06-15 |
BR0013235A (pt) | 2002-04-23 |
US20030055229A1 (en) | 2003-03-20 |
US6566530B2 (en) | 2003-05-20 |
HUP0202819A2 (hu) | 2002-12-28 |
DE60019763D1 (de) | 2005-06-02 |
US6265553B1 (en) | 2001-07-24 |
CZ2002483A3 (cs) | 2002-05-15 |
JP2003506444A (ja) | 2003-02-18 |
HUP0202819A3 (en) | 2004-03-01 |
CA2380838A1 (en) | 2001-02-15 |
CN1169800C (zh) | 2004-10-06 |
US20030191321A1 (en) | 2003-10-09 |
CN1368966A (zh) | 2002-09-11 |
ATE294166T1 (de) | 2005-05-15 |
AU778367B2 (en) | 2004-12-02 |
AU6836400A (en) | 2001-03-05 |
TR200202474T2 (tr) | 2003-01-21 |
US6476230B1 (en) | 2002-11-05 |
EP1202979B1 (en) | 2005-04-27 |
MXPA02001246A (es) | 2002-07-22 |
RU2002105516A (ru) | 2003-09-20 |
AR030258A1 (es) | 2003-08-20 |
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