WO1998043958A1 - Verfahren zur herstellung von 2,6-dichlor-5-fluornicotinonitril und die chemische verbindung 3-cyano-2-hydroxy-5-fluorpyrid-6-on-mononatriumsalz sowie dessen tautomere - Google Patents
Verfahren zur herstellung von 2,6-dichlor-5-fluornicotinonitril und die chemische verbindung 3-cyano-2-hydroxy-5-fluorpyrid-6-on-mononatriumsalz sowie dessen tautomere Download PDFInfo
- Publication number
- WO1998043958A1 WO1998043958A1 PCT/EP1998/001617 EP9801617W WO9843958A1 WO 1998043958 A1 WO1998043958 A1 WO 1998043958A1 EP 9801617 W EP9801617 W EP 9801617W WO 9843958 A1 WO9843958 A1 WO 9843958A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cyano
- hydroxy
- tautomers
- dichloro
- solvent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B39/00—Halogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL13197398A IL131973A0 (en) | 1997-04-01 | 1998-03-19 | Method for the production of 2, 6-dichloro -5- fluoronicontinonitrile and the chemical compound 3-cyano-2-hydroxy -5-fluoropyridine-6-one-monosodium salt and its tautomers |
KR1019997008917A KR20010005843A (ko) | 1997-04-01 | 1998-03-19 | 2,6-디클로로-5-플루오로니코티노니트릴의 제조 방법 및 화합물 3-시아노-2-히드록시-5-플루오로피리드-6-온- 일나트륨염과 그의 토토머 |
CA002285365A CA2285365A1 (en) | 1997-04-01 | 1998-03-19 | Method for the production of 2,6-dichloro-5-fluoronicotinonitrile and the chemical compound 3-cyano-2-hydroxy-5-fluoropyride-6-one-monosodium salt and its tautomers |
PL98335939A PL335939A1 (en) | 1997-04-01 | 1998-03-19 | Method of and system for obtaining 2,6-dichloro-5-fluoronicotinonitrile as well as monosodium salt of 3-cyano-2-hydroxy-5-fluoropyrid-6-one and its tautomers |
HU0003630A HUP0003630A2 (en) | 1997-04-01 | 1998-03-19 | Method for the production of 2,6-dichloro-5-fluoronicotinonitrile and the chemical compound 3-cyano-2-hydroxy-5-fluoropyride-6-one-monosodium salt and its tautomers |
US09/402,047 US6197964B1 (en) | 1997-04-01 | 1998-03-19 | Method for the production of 2,6-dichloro-5-fluoronicotinonitrile and the chemical compound 3-cyano-2-hydroxy-5-fluoropyride-6-one-monosodium salt its tautomers |
AU70385/98A AU7038598A (en) | 1997-04-01 | 1998-03-19 | Method for the production of 2,6-dichloro-5-fluoronicotinonitrile and the chemical compound 3-cyano-2-hydroxy-5-fluoropyride-6-one-monosodium salt and its tautomers |
EP98917018A EP0973745A1 (de) | 1997-04-01 | 1998-03-19 | Verfahren zur herstellung von 2,6-dichlor-5-fluornicotinonitril und die chemische verbindung 3-cyano-2-hydroxy-5-fluorpyrid-6-on-mononatriumsalz sowie dessen tautomere |
JP54110698A JP2001516364A (ja) | 1997-04-01 | 1998-03-19 | 2,6−ジクロロ−5−フルオロニコチノニトリルの製造方法、及び化合物3−シアノ−2−ヒドロキシ−5−フルオロピリド−6−オン−ナトリウム塩とその互変異性体 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19713506A DE19713506A1 (de) | 1997-04-01 | 1997-04-01 | Verfahren zur Herstellung von 2,6-Dichlor-5-fluornicotinonitril und die chemische Verbindung 3-Cyano-2-hydroxy-5-fluorpyrid-6-on-mononatriumsalz sowie dessen Tautomere |
DE19713506.4 | 1997-04-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998043958A1 true WO1998043958A1 (de) | 1998-10-08 |
Family
ID=7825169
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1998/001617 WO1998043958A1 (de) | 1997-04-01 | 1998-03-19 | Verfahren zur herstellung von 2,6-dichlor-5-fluornicotinonitril und die chemische verbindung 3-cyano-2-hydroxy-5-fluorpyrid-6-on-mononatriumsalz sowie dessen tautomere |
Country Status (13)
Country | Link |
---|---|
US (1) | US6197964B1 (de) |
EP (1) | EP0973745A1 (de) |
JP (1) | JP2001516364A (de) |
KR (1) | KR20010005843A (de) |
CN (1) | CN1259123A (de) |
AU (1) | AU7038598A (de) |
CA (1) | CA2285365A1 (de) |
DE (1) | DE19713506A1 (de) |
HU (1) | HUP0003630A2 (de) |
IL (1) | IL131973A0 (de) |
PL (1) | PL335939A1 (de) |
TW (1) | TW509662B (de) |
WO (1) | WO1998043958A1 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000327661A (ja) * | 1999-04-21 | 2000-11-28 | Ruetgers Organics Gmbh | 塩素化されたピリジンスルホン酸クロリドの製造方法 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7252667B2 (en) * | 2003-11-19 | 2007-08-07 | Sherwood Services Ag | Open vessel sealing instrument with cutting mechanism and distal lockout |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0333020A2 (de) * | 1988-03-18 | 1989-09-20 | Abbott Laboratories | Verfahren zur Herstellung von substituierten Pyridinen |
WO1995026340A1 (fr) * | 1994-03-29 | 1995-10-05 | Ihara Chemical Industry Co., Ltd. | Procede d'obtention de cyanopyridine |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2307444A1 (de) | 1973-02-15 | 1974-08-22 | Basf Ag | 2,6-dichlor-3-cyan-pyridin |
DE2814330C3 (de) * | 1978-04-03 | 1981-06-11 | Cassella Ag, 6000 Frankfurt | Verfahren zur Herstellung von 2,6-Dichlorpyridin-D erivaten |
JPS60228479A (ja) | 1984-04-26 | 1985-11-13 | Toyama Chem Co Ltd | 1,4−ジヒドロ−4−オキソナフチリジン誘導体およびその塩 |
-
1997
- 1997-04-01 DE DE19713506A patent/DE19713506A1/de not_active Withdrawn
-
1998
- 1998-03-16 TW TW087103788A patent/TW509662B/zh active
- 1998-03-19 HU HU0003630A patent/HUP0003630A2/hu unknown
- 1998-03-19 WO PCT/EP1998/001617 patent/WO1998043958A1/de not_active Application Discontinuation
- 1998-03-19 EP EP98917018A patent/EP0973745A1/de not_active Withdrawn
- 1998-03-19 CN CN98805701A patent/CN1259123A/zh active Pending
- 1998-03-19 US US09/402,047 patent/US6197964B1/en not_active Expired - Fee Related
- 1998-03-19 CA CA002285365A patent/CA2285365A1/en not_active Abandoned
- 1998-03-19 IL IL13197398A patent/IL131973A0/xx unknown
- 1998-03-19 PL PL98335939A patent/PL335939A1/xx unknown
- 1998-03-19 KR KR1019997008917A patent/KR20010005843A/ko not_active Application Discontinuation
- 1998-03-19 AU AU70385/98A patent/AU7038598A/en not_active Abandoned
- 1998-03-19 JP JP54110698A patent/JP2001516364A/ja active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0333020A2 (de) * | 1988-03-18 | 1989-09-20 | Abbott Laboratories | Verfahren zur Herstellung von substituierten Pyridinen |
WO1995026340A1 (fr) * | 1994-03-29 | 1995-10-05 | Ihara Chemical Industry Co., Ltd. | Procede d'obtention de cyanopyridine |
EP0700903A1 (de) * | 1994-03-29 | 1996-03-13 | Ihara Chemical Industry Co., Ltd. | Verfahren zur herstellung von cyanopyridin |
Non-Patent Citations (1)
Title |
---|
T. MIYAMOTO ET AL.: "Pyridonecarboxylic acids as antibacterial agents. VIII. An alternative synthesis of Enoxacin via fluoronicotinic acid derivatives", CHEMICAL AND PHARMACEUTICAL BULLETIN., vol. 35, no. 6, 1987, TOKYO JP, pages 2280 - 2285, XP002073588 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000327661A (ja) * | 1999-04-21 | 2000-11-28 | Ruetgers Organics Gmbh | 塩素化されたピリジンスルホン酸クロリドの製造方法 |
JP4695742B2 (ja) * | 1999-04-21 | 2011-06-08 | リュートガース オーガニクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 塩素化されたピリジンスルホン酸クロリドの製造方法 |
Also Published As
Publication number | Publication date |
---|---|
IL131973A0 (en) | 2001-03-19 |
DE19713506A1 (de) | 1998-10-08 |
EP0973745A1 (de) | 2000-01-26 |
PL335939A1 (en) | 2000-05-22 |
US6197964B1 (en) | 2001-03-06 |
HUP0003630A2 (en) | 2001-03-28 |
CA2285365A1 (en) | 1998-10-08 |
AU7038598A (en) | 1998-10-22 |
TW509662B (en) | 2002-11-11 |
JP2001516364A (ja) | 2001-09-25 |
CN1259123A (zh) | 2000-07-05 |
KR20010005843A (ko) | 2001-01-15 |
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