WO1996009378A1 - Overexpression of mammalian and viral proteins - Google Patents
Overexpression of mammalian and viral proteins Download PDFInfo
- Publication number
- WO1996009378A1 WO1996009378A1 PCT/US1995/011511 US9511511W WO9609378A1 WO 1996009378 A1 WO1996009378 A1 WO 1996009378A1 US 9511511 W US9511511 W US 9511511W WO 9609378 A1 WO9609378 A1 WO 9609378A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- gene
- protein
- seq
- codons
- synthetic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8510951A JPH10506278A (ja) | 1994-09-19 | 1995-09-08 | 哺乳動物蛋白質及びウイルス蛋白質の過剰発現 |
EP95931798A EP0781329B2 (de) | 1994-09-19 | 1995-09-08 | Überexpression von säugetier- und virusproteinen |
CA002200342A CA2200342C (en) | 1994-09-19 | 1995-09-08 | Overexpression of mammalian and viral proteins |
AU35099/95A AU3509995A (en) | 1994-09-19 | 1995-09-08 | Overexpression of mammalian and viral proteins |
DE69535147T DE69535147T3 (de) | 1994-09-19 | 1995-09-08 | Überexpression von säugetier- und virusproteinen |
DK95931798.3T DK0781329T4 (da) | 1994-09-19 | 1995-09-08 | Overekspression af pattedyr- og virale proteiner |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/324,243 | 1994-09-19 | ||
US08324243 US5786464C1 (en) | 1994-09-19 | 1994-09-19 | Overexpression of mammalian and viral proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996009378A1 true WO1996009378A1 (en) | 1996-03-28 |
Family
ID=23262728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1995/011511 WO1996009378A1 (en) | 1994-09-19 | 1995-09-08 | Overexpression of mammalian and viral proteins |
Country Status (13)
Country | Link |
---|---|
US (1) | US5786464C1 (de) |
EP (1) | EP0781329B2 (de) |
JP (1) | JPH10506278A (de) |
AT (1) | ATE335078T1 (de) |
AU (1) | AU3509995A (de) |
CA (1) | CA2200342C (de) |
DE (1) | DE69535147T3 (de) |
DK (1) | DK0781329T4 (de) |
ES (1) | ES2270430T5 (de) |
PT (1) | PT781329E (de) |
TR (1) | TR199501134A2 (de) |
WO (1) | WO1996009378A1 (de) |
ZA (1) | ZA957846B (de) |
Cited By (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998012207A1 (en) * | 1996-09-20 | 1998-03-26 | The General Hospital Corporation | High level expression of proteins |
EP0851868A1 (de) * | 1995-09-22 | 1998-07-08 | The General Hospital Corporation | Hohe expressionsrate von proteinen |
WO1998034640A2 (en) * | 1997-02-07 | 1998-08-13 | Merck & Co., Inc. | Synthetic hiv gag genes |
EP1002091A1 (de) * | 1997-07-09 | 2000-05-24 | The University Of Queensland | Nukleinsäuresequenz und verfahren zur selektiven expression eines proteins in einer zielzelle oder -gewebe |
WO2000039304A2 (en) * | 1998-12-31 | 2000-07-06 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
WO2001068835A2 (en) * | 2000-03-13 | 2001-09-20 | Aptagen | Method for modifying a nucleic acid |
WO2002008417A1 (fr) * | 2000-07-25 | 2002-01-31 | Takeda Chemical Industries, Ltd. | Procede de production d'une proteine de recombinaison |
JP2002503477A (ja) * | 1998-02-17 | 2002-02-05 | オックスフォード バイオメディカ(ユーケイ)リミテッド | 抗ウイルスベクター |
WO2002042326A1 (en) * | 2000-11-22 | 2002-05-30 | Biota Scientific Management Pty Ltd | A method of expression and agents identified thereby |
WO2002083181A1 (en) | 2001-04-18 | 2002-10-24 | The University Of Queensland | Novel compositions and uses therefor |
US6489141B1 (en) * | 1997-07-09 | 2002-12-03 | The University Of Queensland | Nucleic acid sequence and methods for selectively expressing a protein in a target cell or tissue |
US6534312B1 (en) | 1996-02-22 | 2003-03-18 | Merck & Co., Inc. | Vaccines comprising synthetic genes |
WO2003025003A2 (en) * | 2001-09-20 | 2003-03-27 | Glaxo Group Limited | Hiv-gag codon-optimised dna vaccines |
WO2002064799A3 (en) * | 1999-09-28 | 2003-03-27 | Transkaryotic Therapies Inc | Optimized messenger rna |
US6649409B1 (en) | 1999-03-29 | 2003-11-18 | Statens Serum Institut | Method for producing a nucleotide sequence construct with optimized codons for an HIV genetic vaccine based on a primary, early HIV isolate and synthetic envelope BX08 constructs |
US6656706B2 (en) | 1999-12-23 | 2003-12-02 | The United States Of America As Represented By The Department Of Health And Human Services | Molecular clones with mutated HIV gag/pol, SIV gag and SIV env genes |
US6696291B2 (en) | 1997-02-07 | 2004-02-24 | Merck & Co., Inc. | Synthetic HIV gag genes |
EP1535995A1 (de) * | 1998-12-31 | 2005-06-01 | Chiron Corporation | Polynukleotide kodierend für Antigene des HIV Type C ENV Polypeptids, und Verwendungen davon |
US6924365B1 (en) | 1998-09-29 | 2005-08-02 | Transkaryotic Therapies, Inc. | Optimized messenger RNA |
WO2008049782A1 (en) * | 2006-10-24 | 2008-05-02 | Basf Se | Method of increasing gene expression using modified codon usage |
US7935805B1 (en) | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
US8133494B2 (en) | 2001-07-05 | 2012-03-13 | Novartis Vaccine & Diagnostics Inc | Expression cassettes endcoding HIV-1 south african subtype C modified ENV proteins with deletions in V1 and V2 |
WO2013139916A1 (en) | 2012-03-22 | 2013-09-26 | Crucell Holland B.V. | Vaccine against rsv |
US9119813B2 (en) | 2012-03-22 | 2015-09-01 | Crucell Holland B.V. | Vaccine against RSV |
WO2017005844A1 (en) | 2015-07-07 | 2017-01-12 | Janssen Vaccines & Prevention B.V. | Vaccine against rsv |
WO2017037196A1 (en) | 2015-09-02 | 2017-03-09 | Janssen Vaccines & Prevention B.V. | Stabilized viral class i fusion proteins |
US9701721B2 (en) | 2014-11-04 | 2017-07-11 | Janssen Vaccines & Prevention B.V. | Therapeutic HPV16 vaccines |
US9790256B2 (en) | 2015-08-20 | 2017-10-17 | Janssen Vaccines & Prevention B.V. | Therapeutic HPV18 vaccines |
WO2017207480A1 (en) | 2016-05-30 | 2017-12-07 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv f proteins |
WO2017207477A1 (en) | 2016-05-30 | 2017-12-07 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv f proteins |
WO2018087285A1 (en) | 2016-11-10 | 2018-05-17 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Or10h1 antigen binding proteins and uses thereof |
WO2018160573A1 (en) | 2017-02-28 | 2018-09-07 | The Trustees Of The University Of Pennsylvania | Influenza vaccines based on aav vectors |
WO2019053109A1 (en) | 2017-09-15 | 2019-03-21 | Janssen Vaccines & Prevention B.V. | METHOD FOR SAFE INDUCTION OF IMMUNITY AGAINST RSV |
US10294279B2 (en) | 2013-06-17 | 2019-05-21 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion RSV F polypeptides |
US10293058B2 (en) | 2015-04-22 | 2019-05-21 | Curevac Ag | RNA containing composition for treatment of tumor diseases |
EP3488864A1 (de) | 2013-04-25 | 2019-05-29 | Janssen Vaccines & Prevention B.V. | Stabilisierte lösliche 'pre-fusion' rsv-f-polypeptide |
EP3508499A1 (de) | 2018-01-08 | 2019-07-10 | iOmx Therapeutics AG | Antikörper zum targeting von, und andere modulatoren von, einem immunglobulingen im zusammenhang mit resistenz gegen antitumor-immunantworten und verwendungen davon |
WO2019145310A1 (en) | 2018-01-23 | 2019-08-01 | Janssen Vaccines & Prevention B.V. | Influenza virus vaccines and uses thereof |
US10457708B2 (en) | 2015-07-07 | 2019-10-29 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion RSV F polypeptides |
US10517944B2 (en) | 2016-05-02 | 2019-12-31 | Janssen Vaccines & Prevention B.V. | Therapeutic HPV vaccine combinations |
WO2020099383A1 (en) | 2018-11-13 | 2020-05-22 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv f proteins |
US10729757B2 (en) | 2016-04-05 | 2020-08-04 | Janssen Vaccines & Prevention B.V. | Vaccine against RSV |
WO2020216844A1 (en) | 2019-04-25 | 2020-10-29 | Janssen Vaccines & Prevention B.V. | Recombinant influenza antigens |
WO2021005009A1 (en) | 2019-07-05 | 2021-01-14 | Iomx Therapeutics Ag | Antibodies binding igc2 of igsf11 (vsig3) and uses thereof |
WO2021043869A1 (en) | 2019-09-05 | 2021-03-11 | Janssen Vaccines & Prevention B.V. | Influenza virus vaccines and uses thereof |
EP3808374A1 (de) | 2016-04-05 | 2021-04-21 | Janssen Vaccines & Prevention B.V. | Stabilisiertes losliches prafusioniertes rsv-f-protein zur verwenduing bei der prophylaxe einer rsv infektion |
EP3822288A1 (de) | 2019-11-18 | 2021-05-19 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Gegen das cd276-antigen gerichtete antikörper, und andere modulatoren gegen das cd276-antigen, und deren verwendung |
WO2021228842A1 (en) | 2020-05-11 | 2021-11-18 | Janssen Pharmaceuticals, Inc. | Stabilized coronavirus spike protein fusion proteins |
WO2021229448A1 (en) | 2020-05-11 | 2021-11-18 | Janssen Pharmaceuticals, Inc. | Rna replicon encoding a stabilized corona virus spike protein |
WO2021257668A1 (en) | 2020-06-17 | 2021-12-23 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of gene therapy patients |
WO2022008438A1 (en) | 2020-07-06 | 2022-01-13 | Janssen Pharmaceuticals, Inc. | Stabilized corona virus spike protein fusion proteins |
WO2022008027A1 (en) | 2020-07-06 | 2022-01-13 | Iomx Therapeutics Ag | Antibodies binding igv of igsf11 (vsig3) and uses thereof |
US11229692B2 (en) | 2017-05-17 | 2022-01-25 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against RSV infection |
WO2022076803A1 (en) | 2020-10-09 | 2022-04-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of fabry disease |
EP3992205A1 (de) | 2020-11-03 | 2022-05-04 | Rheinische Friedrich-Wilhelms-Universität Bonn | Verbindung zum binden des sars coronavirus-2 spike-proteins |
WO2022096536A1 (en) | 2020-11-03 | 2022-05-12 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Target-cell restricted, costimulatory, bispecific and bivalent anti-cd28 antibodies |
WO2022106205A1 (en) | 2020-11-18 | 2022-05-27 | Rheinische Friedrich-Wilhelms-Universität Bonn | Corona virus spike protein binding compounds |
WO2022175477A1 (en) | 2021-02-19 | 2022-08-25 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv fb antigens |
WO2022180007A1 (en) | 2021-02-23 | 2022-09-01 | Janssen Vaccines & Prevention B.V. | Trimer stabilizing hiv envelope protein mutation |
WO2022184845A1 (en) | 2021-03-03 | 2022-09-09 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Bispecific antibodies enhancing cell mediated immune responses |
WO2022207839A2 (en) | 2021-04-01 | 2022-10-06 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion piv3 f proteins |
US11535665B2 (en) | 2015-05-13 | 2022-12-27 | The Trustees Of The University Of Pennsylvania | AAV-mediated expression of anti-influenza antibodies and methods of use thereof |
US11555206B2 (en) | 2017-11-30 | 2023-01-17 | The Trustees Of The University Of Pennsylvania | Gene therapy for mucopolysaccharidosis IIIA |
US11578341B2 (en) | 2017-02-28 | 2023-02-14 | The Trustees Of The University Of Pennsylvania | Compositions useful in treatment of spinal muscular atrophy |
WO2023047349A1 (en) | 2021-09-24 | 2023-03-30 | Janssen Pharmaceuticals, Inc. | Stabilized coronavirus spike protein fusion proteins |
WO2023047348A1 (en) | 2021-09-24 | 2023-03-30 | Janssen Pharmaceuticals, Inc. | Stabilized corona virus spike protein fusion proteins |
WO2023102517A1 (en) | 2021-12-02 | 2023-06-08 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of fabry disease |
WO2023110618A1 (en) | 2021-12-16 | 2023-06-22 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion hmpv fusion proteins |
US11723989B2 (en) | 2017-11-30 | 2023-08-15 | The Trustees Of The University Of Pennsylvania | Gene therapy for mucopolysaccharidosis IIIB |
WO2023156505A1 (en) | 2022-02-17 | 2023-08-24 | Janssen Vaccines & Prevention B.V. | Trimer stabilizing hiv envelope protein mutations r304v, n302m and t320l |
WO2023196893A1 (en) | 2022-04-06 | 2023-10-12 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating her2 positive metastatic breast cancer and other cancers |
WO2023196892A1 (en) | 2022-04-06 | 2023-10-12 | The Trustees Of The University Of Pennsylvania | Passive immunization with anti- aav neutralizing antibodies to prevent off-target transduction of intrathecally delivered aav vectors |
WO2023217988A1 (en) | 2022-05-12 | 2023-11-16 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion hmpv fusion proteins |
US11827906B2 (en) | 2017-02-28 | 2023-11-28 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus (AAV) clade f vector and uses therefor |
WO2024017682A1 (en) | 2022-07-18 | 2024-01-25 | Janssen Vaccines & Prevention B.V. | Rsv immunogens |
WO2024061753A1 (en) | 2022-09-23 | 2024-03-28 | Janssen Vaccines & Prevention B.V. | Stabilized trimeric class i fusion proteins |
WO2024061757A1 (en) | 2022-09-23 | 2024-03-28 | Janssen Vaccines & Prevention B.V. | Pre-fusion human piv1 f proteins |
WO2024061759A1 (en) | 2022-09-23 | 2024-03-28 | Janssen Vaccines & Prevention B.V. | Stabilized coronavirus s proteins |
WO2024074584A1 (en) | 2022-10-06 | 2024-04-11 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion piv3 f proteins |
WO2024084082A1 (en) | 2022-10-21 | 2024-04-25 | Meatable B.V. | Adipocyte maturation |
Families Citing this family (182)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050074752A1 (en) * | 1996-06-11 | 2005-04-07 | Merck & Co., Inc. | Synthetic hepatitis C genes |
AU717542B2 (en) | 1996-06-11 | 2000-03-30 | Merck & Co., Inc. | Synthetic hepatitis C genes |
AU747522B2 (en) * | 1997-07-09 | 2002-05-16 | University Of Queensland, The | Nucleic acid sequence and method for selectively expressing a protein in a target cell or tissue |
US6602677B1 (en) * | 1997-09-19 | 2003-08-05 | Promega Corporation | Thermostable luciferases and methods of production |
US20090017533A1 (en) * | 1998-09-29 | 2009-01-15 | Shire Human Genetic Therapies, Inc., A Delaware Corporation | Optimized messenger rna |
WO2000039302A2 (en) | 1998-12-31 | 2000-07-06 | Chiron Corporation | Improved expression of hiv polypeptides and production of virus-like particles |
EP1433851A3 (de) * | 1998-12-31 | 2004-10-13 | Chiron Corporation | Verbesserte exprimierung von HIV Polypeptiden und Herstellung von virusähnliche Partikeln |
CA2358915C (en) | 1998-12-31 | 2010-06-01 | Chiron Corporation | Modified hiv env polypeptides |
AU2868200A (en) * | 1999-02-08 | 2000-08-25 | Chiron Corporation | Electrically-mediated enhancement of dna vaccine immunity and efficacy in vivo |
US7270984B1 (en) * | 1999-06-25 | 2007-09-18 | Basf Aktiengesellschaft | Polynucleotides encoding a 6-phosphogluconolactonase polypeptide from corynebacterium glutamicum |
US7332275B2 (en) | 1999-10-13 | 2008-02-19 | Sequenom, Inc. | Methods for detecting methylated nucleotides |
US20030096778A1 (en) * | 2002-06-13 | 2003-05-22 | Shiver John W | Polynucleotide vaccines expressing codon optimized hiv-1 nef and modified hiv-1 nef |
US20040063653A1 (en) * | 2000-12-21 | 2004-04-01 | Shiver John W. | Polynucleotide vaccines expressing codon optimized hiv-1 pol and modified hiv-1 pol |
US6502774B1 (en) * | 2000-03-08 | 2003-01-07 | J + L Fiber Services, Inc. | Refiner disk sensor and sensor refiner disk |
GB0009760D0 (en) * | 2000-04-19 | 2000-06-07 | Oxford Biomedica Ltd | Method |
GB0017990D0 (en) * | 2000-07-21 | 2000-09-13 | Glaxo Group Ltd | Papilloma virus sequences |
US20030157643A1 (en) * | 2000-08-24 | 2003-08-21 | Almond Brian D | Synthetic nucleic acids from aquatic species |
US7879540B1 (en) * | 2000-08-24 | 2011-02-01 | Promega Corporation | Synthetic nucleic acid molecule compositions and methods of preparation |
EP2305699B1 (de) * | 2001-06-05 | 2014-08-13 | CureVac GmbH | Stabilisierte mRNA mit erhöhtem G/C-Gehalt und optimierter Codon Usage für die Impfung gegen Schlafkrankheit, Leishmaniose und Toxoplasmose |
US6780974B2 (en) * | 2001-06-12 | 2004-08-24 | Cellomics, Inc. | Synthetic DNA encoding an orange seapen-derived green fluorescent protein with codon preference of mammalian expression systems and biosensors |
CA2458995C (en) * | 2001-08-31 | 2013-04-30 | Chiron Corporation | Polynucleotides encoding antigenic hiv type b polypeptides, polypeptides and uses thereof |
US7413874B2 (en) * | 2002-12-09 | 2008-08-19 | University Of Miami | Nucleic acid encoding fluorescent proteins from aquatic species |
US20050124017A1 (en) * | 2003-12-05 | 2005-06-09 | Stewart Lebrun | Quantitative alkaline-phosphatase precipitation reagent and methods for visualization of protein microarrays |
WO2005118874A1 (en) * | 2004-06-04 | 2005-12-15 | Wyeth | Enhancing protein expression |
US20080044853A1 (en) | 2004-06-21 | 2008-02-21 | Novozymes A/S | Stably Maintained Multiple Copies of at Least Two Orf in the Same Orientation |
US7728118B2 (en) | 2004-09-17 | 2010-06-01 | Promega Corporation | Synthetic nucleic acid molecule compositions and methods of preparation |
ES2370040T3 (es) | 2005-10-07 | 2011-12-12 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.R.L. | Vacuna de metaloproteinasa 11 de la matriz. |
NZ569541A (en) | 2006-01-13 | 2012-05-25 | Us Gov Health & Human Serv | Codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells |
WO2008118445A1 (en) * | 2007-03-26 | 2008-10-02 | Promega Corporation | Methods to quench light from optical reactions |
EP1997830A1 (de) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV-spezifische Bindemoleküle und Mittel zu ihrer Herstellung |
US20120040367A1 (en) * | 2007-10-15 | 2012-02-16 | The University Of Queensland | Construct system and uses therefor |
EP2612868B1 (de) | 2007-11-01 | 2018-08-15 | Astellas Pharma Inc. | Immunsuppressive Polypeptide und Nucleinsäuren |
US7561973B1 (en) | 2008-07-31 | 2009-07-14 | Dna Twopointo, Inc. | Methods for determining properties that affect an expression property value of polynucleotides in an expression system |
US8126653B2 (en) * | 2008-07-31 | 2012-02-28 | Dna Twopointo, Inc. | Synthetic nucleic acids for expression of encoded proteins |
US7561972B1 (en) | 2008-06-06 | 2009-07-14 | Dna Twopointo, Inc. | Synthetic nucleic acids for expression of encoded proteins |
US8401798B2 (en) * | 2008-06-06 | 2013-03-19 | Dna Twopointo, Inc. | Systems and methods for constructing frequency lookup tables for expression systems |
US9795658B2 (en) | 2010-04-20 | 2017-10-24 | Admedus Vaccines Pty Ltd | Expression system for modulating an immune response |
CA2824155A1 (en) | 2011-01-17 | 2012-07-26 | Philip Morris Products S.A. | Vectors for nucleic acid expression in plants |
CN103403170B (zh) | 2011-01-17 | 2015-11-25 | 菲利普莫里斯生产公司 | 植物中的蛋白质表达 |
EP2768607B1 (de) | 2011-09-26 | 2021-08-18 | Thermo Fisher Scientific GENEART GmbH | Multiwell-platte für die hocheffiziente kleinvolumige nukleinsäuresynthese |
WO2014153188A2 (en) | 2013-03-14 | 2014-09-25 | Life Technologies Corporation | High efficiency, small volume nucleic acid synthesis |
JP5775974B2 (ja) | 2011-10-28 | 2015-09-09 | プロセナ バイオサイエンシーズ リミテッド | アルファシヌクレインを認識するヒト化抗体 |
WO2013112945A1 (en) | 2012-01-27 | 2013-08-01 | Neotope Biosciences Limited | Humanized antibodies that recognize alpha-synuclein |
US20130274129A1 (en) | 2012-04-04 | 2013-10-17 | Geneart Ag | Tal-effector assembly platform, customized services, kits and assays |
UA118441C2 (uk) | 2012-10-08 | 2019-01-25 | Протена Біосаєнсиз Лімітед | Антитіло, що розпізнає альфа-синуклеїн |
UY35340A (es) | 2013-02-20 | 2014-09-30 | Novartis Ag | Marcaje efectivo de leucemia humana usando células diseñadas con un receptor quimérico de antígeno anti-cd123 |
CN111139256A (zh) | 2013-02-20 | 2020-05-12 | 诺华股份有限公司 | 使用人源化抗EGFRvIII嵌合抗原受体治疗癌症 |
PE20152004A1 (es) | 2013-03-13 | 2016-02-07 | Prothena Biosciences Ltd | Inmunoterapia tau |
UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
WO2015012924A2 (en) | 2013-04-29 | 2015-01-29 | The Trustees Of The University Of Pennsylvania | Tissue preferential codon modified expression cassettes, vectors containing same, and use thereof |
EP3816625A1 (de) | 2013-05-06 | 2021-05-05 | Scholar Rock, Inc. | Zusammensetzungen und verfahren zur modulation von wachstumsfaktoren |
US10513555B2 (en) | 2013-07-04 | 2019-12-24 | Prothena Biosciences Limited | Antibody formulations and methods |
WO2015004632A1 (en) | 2013-07-12 | 2015-01-15 | Neotope Biosciences Limited | Antibodies that recognize iapp |
WO2015004633A1 (en) | 2013-07-12 | 2015-01-15 | Neotope Biosciences Limited | Antibodies that recognize islet-amyloid polypeptide (iapp) |
WO2015075635A2 (en) | 2013-11-19 | 2015-05-28 | Prothena Biosciences Limited | Monitoring immunotherapy of lewy body disease from constipation symptoms |
WO2015090230A1 (en) | 2013-12-19 | 2015-06-25 | Novartis Ag | Human mesothelin chimeric antigen receptors and uses thereof |
PT3116911T (pt) | 2014-03-12 | 2019-09-04 | Prothena Biosciences Ltd | Anticorpos anti-mcam e métodos de utilização associados |
TW201623331A (zh) | 2014-03-12 | 2016-07-01 | 普羅帝納生物科學公司 | 抗黑色素瘤細胞黏著分子(mcam)抗體類及使用彼等之相關方法 |
KR20160131082A (ko) | 2014-03-12 | 2016-11-15 | 프로테나 바이오사이언시즈 리미티드 | Lg1-3에 특이적인 항-라미닌4 항체 |
CA2938933A1 (en) | 2014-03-12 | 2015-09-17 | Prothena Biosciences Limited | Anti-laminin4 antibodies specific for lg4-5 |
EP3593812A3 (de) | 2014-03-15 | 2020-05-27 | Novartis AG | Behandlung von krebs mithilfe eines chimären antigenrezeptors |
IL293603B2 (en) | 2014-04-07 | 2024-03-01 | Novartis Ag | Cancer treatment using chimeric antigen receptor (CAR) against CD19 |
EP3129051A1 (de) | 2014-04-08 | 2017-02-15 | Prothena Biosciences Limited | Blut-hirn-schranken-shuttle mit antikörpern zur erkennung von alpha-synuklein |
US9777061B2 (en) | 2014-07-21 | 2017-10-03 | Novartis Ag | Treatment of cancer using a CD33 chimeric antigen receptor |
JP2017528433A (ja) | 2014-07-21 | 2017-09-28 | ノバルティス アーゲー | 低い免疫増強用量のmTOR阻害剤とCARの組み合わせ |
JP7084138B2 (ja) | 2014-08-19 | 2022-06-14 | ノバルティス アーゲー | 癌処置に使用するための抗cd123キメラ抗原受容体(car) |
US9879087B2 (en) | 2014-11-12 | 2018-01-30 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
EP4183806A3 (de) | 2014-11-12 | 2023-08-02 | Seagen Inc. | Glycaninteragierende verbindungen und verfahren zur verwendung |
CN107532129B (zh) | 2014-12-09 | 2022-09-13 | 生命技术公司 | 高效小体积核酸合成 |
US10273300B2 (en) | 2014-12-29 | 2019-04-30 | The Trustees Of The University Of Pennsylvania | Methods of making chimeric antigen receptor-expressing cells |
TWI718121B (zh) | 2015-01-28 | 2021-02-11 | 愛爾蘭商普羅佘納生物科技有限公司 | 抗甲狀腺素運送蛋白抗體 |
TWI769570B (zh) | 2015-01-28 | 2022-07-01 | 愛爾蘭商普羅佘納生物科技有限公司 | 抗甲狀腺素運送蛋白抗體 |
TWI718122B (zh) | 2015-01-28 | 2021-02-11 | 愛爾蘭商普羅佘納生物科技有限公司 | 抗甲狀腺素運送蛋白抗體 |
WO2016164580A1 (en) | 2015-04-07 | 2016-10-13 | Novartis Ag | Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives |
RU2021121771A (ru) | 2015-04-08 | 2022-01-12 | Новартис Аг | Cd20 терапия, cd22 терапия и комбинированная терапия клетками, экспрессирующими химерный антигенный рецептор (car) к cd19 |
WO2016168595A1 (en) | 2015-04-17 | 2016-10-20 | Barrett David Maxwell | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
WO2016172583A1 (en) | 2015-04-23 | 2016-10-27 | Novartis Ag | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
WO2016180430A1 (en) | 2015-05-08 | 2016-11-17 | Curevac Ag | Method for producing rna |
WO2016193206A1 (en) | 2015-05-29 | 2016-12-08 | Curevac Ag | A method for producing and purifying rna, comprising at least one step of tangential flow filtration |
AU2016297014B2 (en) | 2015-07-21 | 2021-06-17 | Novartis Ag | Methods for improving the efficacy and expansion of immune cells |
WO2017046774A2 (en) | 2015-09-16 | 2017-03-23 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica or takayasu's arteritis |
WO2017046776A2 (en) | 2015-09-16 | 2017-03-23 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica or takayasu's arteritis |
IL302822A (en) | 2015-11-12 | 2023-07-01 | Seagen Inc | Compounds interacting with glycans and methods of use |
CN116334143A (zh) | 2015-11-23 | 2023-06-27 | 诺华股份有限公司 | 优化的慢病毒转移载体及其用途 |
WO2017117112A1 (en) | 2015-12-28 | 2017-07-06 | Novartis Ag | Methods of making chimeric antigen receptor -expressing cells |
EP3397756B1 (de) | 2015-12-30 | 2023-03-08 | Novartis AG | Immuneffektorzelltherapien mit verbesserter wirksamkeit |
US20210198368A1 (en) | 2016-01-21 | 2021-07-01 | Novartis Ag | Multispecific molecules targeting cll-1 |
WO2017149513A1 (en) | 2016-03-03 | 2017-09-08 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
WO2017153955A1 (en) | 2016-03-09 | 2017-09-14 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of granulomatous lung diseases |
WO2017153953A1 (en) | 2016-03-09 | 2017-09-14 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of granulomatous lung diseases |
CN109071646A (zh) | 2016-03-11 | 2018-12-21 | 供石公司 | TGFβ1-结合免疫球蛋白及其用途 |
WO2017165683A1 (en) | 2016-03-23 | 2017-09-28 | Novartis Ag | Cell secreted minibodies and uses thereof |
HRP20230457T1 (hr) | 2016-04-15 | 2023-07-21 | Novartis Ag | Pripravci i postupci za selektivnu ekspresiju kimernih antigenskih receptora |
KR102506091B1 (ko) | 2016-05-02 | 2023-03-07 | 프로테나 바이오사이언시즈 리미티드 | 타우 면역요법 |
CU24537B1 (es) | 2016-05-02 | 2021-07-02 | Prothena Biosciences Ltd | Anticuerpos monoclonales que compiten por unirse a tau humano con el anticuerpo 3d6 |
PE20190208A1 (es) | 2016-05-02 | 2019-02-07 | Prothena Biosciences Ltd | Anticuerpos que reconocen tau |
EP3464375A2 (de) | 2016-06-02 | 2019-04-10 | Novartis AG | Therapeutische schemata für chimäre antigenrezeptor(car)-exprimierende zellen |
WO2017208210A1 (en) | 2016-06-03 | 2017-12-07 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
WO2018007922A2 (en) | 2016-07-02 | 2018-01-11 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
JP7016470B2 (ja) | 2016-07-02 | 2022-02-07 | プロセナ バイオサイエンシーズ リミテッド | 抗トランスサイレチン抗体 |
EP3478716A2 (de) | 2016-07-02 | 2019-05-08 | Prothena Biosciences Limited | Anti-transthyretin-antikörper |
AU2017295886C1 (en) | 2016-07-15 | 2024-01-25 | Novartis Ag | Treatment and prevention of cytokine release syndrome using a chimeric antigen receptor in combination with a kinase inhibitor |
US20190161542A1 (en) | 2016-08-01 | 2019-05-30 | Novartis Ag | Treatment of cancer using a chimeric antigen receptor in combination with an inhibitor of a pro-m2 macrophage molecule |
WO2018067992A1 (en) | 2016-10-07 | 2018-04-12 | Novartis Ag | Chimeric antigen receptors for the treatment of cancer |
EP3541847A4 (de) | 2016-11-17 | 2020-07-08 | Seattle Genetics, Inc. | Glycaninteragierende verbindungen und verfahren zur verwendung |
WO2018111340A1 (en) | 2016-12-16 | 2018-06-21 | Novartis Ag | Methods for determining potency and proliferative function of chimeric antigen receptor (car)-t cells |
EP3551658A1 (de) | 2017-01-06 | 2019-10-16 | Scholar Rock, Inc. | Isoformspezifische, kontextpermissive tgf-1-inhibitoren und verwendung davon |
EP4043485A1 (de) | 2017-01-26 | 2022-08-17 | Novartis AG | Cd28-zusammensetzungen und verfahren für chimäre antigenrezeptortherapie |
WO2018160731A1 (en) | 2017-02-28 | 2018-09-07 | Novartis Ag | Shp inhibitor compositions and uses for chimeric antigen receptor therapy |
KR102653141B1 (ko) | 2017-03-03 | 2024-04-01 | 씨젠 인크. | 글리칸-상호작용 화합물 및 사용 방법 |
EP3615055A1 (de) | 2017-04-28 | 2020-03-04 | Novartis AG | Zellen, die einen auf bcma abzielenden chimären antigenrezeptor exprimieren, und kombinationsbehandlung mit einem gamma-sekretase-inhibitor |
AU2018263935A1 (en) | 2017-05-02 | 2019-12-19 | Prothena Biosciences Limited | Antibodies recognizing tau |
EP3630974A1 (de) | 2017-05-22 | 2020-04-08 | Baxalta Incorporated | Virale vektoren, die für rekombinante fixierer mit erhöhter expression für die gentherapie von hämophilie b codieren |
EP3658583A1 (de) | 2017-07-28 | 2020-06-03 | Scholar Rock, Inc. | Ltbp-komplex-spezifische inhibitoren von tgf-beta 1 und verwendungen davon |
WO2019064053A1 (en) | 2017-09-28 | 2019-04-04 | Prothena Biosciences Limited | DOSAGE REGIMES FOR THE TREATMENT OF SYNUCLEINOPATHIES |
CA3078270A1 (en) | 2017-10-25 | 2019-05-02 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
US20210179709A1 (en) | 2017-10-31 | 2021-06-17 | Novartis Ag | Anti-car compositions and methods |
US20210189367A1 (en) | 2017-12-11 | 2021-06-24 | Senti Biosciences, Inc. | Inducible Cell Receptors for Cell-Based Therapeutics |
US20210163922A1 (en) | 2018-03-19 | 2021-06-03 | Modernatx, Inc. | Assembly and error reduction of synthetic genes from oligonucleotides |
GB201804701D0 (en) | 2018-03-23 | 2018-05-09 | Gammadelta Therapeutics Ltd | Lymphocytes expressing heterologous targeting constructs |
EP3784351A1 (de) | 2018-04-27 | 2021-03-03 | Novartis AG | Car-t-zelltherapien mit erhöhter wirksamkeit |
EP3788369A1 (de) | 2018-05-01 | 2021-03-10 | Novartis Ag | Biomarker zur auswertung von car-t-zellen zur vorhersage des klinischen ergebnisses |
US20210213063A1 (en) | 2018-05-25 | 2021-07-15 | Novartis Ag | Combination therapy with chimeric antigen receptor (car) therapies |
EP3802825A1 (de) | 2018-06-08 | 2021-04-14 | Intellia Therapeutics, Inc. | Zusammensetzungen und verfahren zur immunonkologie |
AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
SI3677278T1 (sl) | 2018-07-11 | 2022-01-31 | Scholar Rock, Inc. | Izoformno selektivni zaviralci TGFBETA1 in uporaba le-teh |
CA3105988A1 (en) | 2018-07-11 | 2020-01-16 | Abhishek Datta | High-affinity, isoform-selective tgf.beta.1 inhibitors and use thereof |
EP3820896A1 (de) | 2018-07-11 | 2021-05-19 | Scholar Rock, Inc. | Tgfbeta1-inhibitoren und verwendung davon |
CA3109959A1 (en) | 2018-08-31 | 2020-03-05 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
US20210171909A1 (en) | 2018-08-31 | 2021-06-10 | Novartis Ag | Methods of making chimeric antigen receptor?expressing cells |
US20220047633A1 (en) | 2018-09-28 | 2022-02-17 | Novartis Ag | Cd22 chimeric antigen receptor (car) therapies |
EP3856782A1 (de) | 2018-09-28 | 2021-08-04 | Novartis AG | Chimärer cd19-antigen-rezeptor (car) und cd22-car-kombinationstherapien |
EP3870286A1 (de) | 2018-10-23 | 2021-09-01 | Scholar Rock, Inc. | Rgmc-selektive inhibitoren und ihre verwendung |
KR20210094610A (ko) | 2018-11-26 | 2021-07-29 | 포티 세븐, 인코포레이티드 | c-Kit에 대한 인간화 항체 |
JP2022514315A (ja) | 2018-12-20 | 2022-02-10 | ノバルティス アーゲー | 3-(1-オキソイソインドリン-2-イル)ピペリジン-2,6-ジオン誘導体を含む投与計画及び薬剤組み合わせ |
MX2021008121A (es) | 2019-01-03 | 2021-12-10 | Inst Nat Sante Rech Med | Metodos y composiciones farmaceuticas para mejorar las respuestas inmunitarias dependientes de celulas t cd8+ en sujetos que sufren de cancer. |
MA54845A (fr) | 2019-01-30 | 2021-09-29 | Scholar Rock Inc | Inhibiteurs de ltbp propres à un complexe de tgf-béta et leurs utilisations |
KR20210129672A (ko) | 2019-02-15 | 2021-10-28 | 노파르티스 아게 | 치환된 3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체 및 이의 용도 |
CA3124935A1 (en) | 2019-02-15 | 2020-08-20 | Novartis Ag | 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
AU2020229806A1 (en) | 2019-02-25 | 2021-07-29 | Novartis Ag | Mesoporous silica particles compositions for viral delivery |
JP2022524588A (ja) | 2019-03-03 | 2022-05-09 | プロセナ バイオサイエンシーズ リミテッド | タウ認識抗体 |
US20220168389A1 (en) | 2019-04-12 | 2022-06-02 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
EP3769816A1 (de) | 2019-07-25 | 2021-01-27 | Ospedale Pediatrico Bambino Gesù | Car-cd123-vektor und verwendungen davon |
CN114761037A (zh) | 2019-11-26 | 2022-07-15 | 诺华股份有限公司 | 结合bcma和cd19的嵌合抗原受体及其用途 |
CN115052662A (zh) | 2019-12-20 | 2022-09-13 | 诺华股份有限公司 | 抗TGFβ抗体和检查点抑制剂用于治疗增殖性疾病的用途 |
CA3167427A1 (en) | 2020-01-11 | 2021-07-15 | Scholar Rock, Inc. | Tgfb inhibitors and use thereof |
US20230050148A1 (en) | 2020-01-11 | 2023-02-16 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
EP4104187A1 (de) | 2020-02-14 | 2022-12-21 | Novartis AG | Verfahren zur vorhersage des ansprechens auf eine chimäre antigen-rezeptor-therapie |
WO2021173995A2 (en) | 2020-02-27 | 2021-09-02 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
CA3173394A1 (en) | 2020-02-27 | 2021-09-02 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
JP2023531676A (ja) | 2020-06-23 | 2023-07-25 | ノバルティス アーゲー | 3-(1-オキソイソインドリン-2-イル)ピぺリジン-2,6-ジオン誘導体を含む投与レジメン |
MX2023000547A (es) | 2020-07-16 | 2023-02-13 | Novartis Ag | Anticuerpos anti-betacelulina, fragmentos de los mismos, y moleculas de union multiespecificas. |
CN116134027A (zh) | 2020-08-03 | 2023-05-16 | 诺华股份有限公司 | 杂芳基取代的3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物及其用途 |
EP4189071A1 (de) | 2020-08-03 | 2023-06-07 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Population von treg-zellen, die funktionell mit einer regulatorischen aktivität behaftet sind, und ihre verwendung zur adoptiven therapie |
EP4199960A2 (de) | 2020-08-21 | 2023-06-28 | Novartis AG | Zusammensetzungen und verfahren zur in-vivo-erzeugung von car-exprimierenden zellen |
CA3198447A1 (en) | 2020-11-13 | 2022-05-19 | Novartis Ag | Combination therapies with chimeric antigen receptor (car)-expressing cells |
KR20240012352A (ko) | 2021-03-23 | 2024-01-29 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | T 세포 림프종의 진단 및 치료 방법 |
WO2022204581A2 (en) | 2021-03-26 | 2022-09-29 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途 |
EP4320153A1 (de) | 2021-04-09 | 2024-02-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Verfahren zur behandlung von anaplastischem grosszelligem lymphom |
WO2022229853A1 (en) | 2021-04-27 | 2022-11-03 | Novartis Ag | Viral vector production system |
WO2022256723A2 (en) | 2021-06-03 | 2022-12-08 | Scholar Rock, Inc. | Tgf-beta inhibitors and therapeutic use thereof |
WO2023288277A1 (en) | 2021-07-14 | 2023-01-19 | Scholar Rock, Inc. | Ltbp complex-specific inhibitors of tgfb1 and uses thereof |
WO2023069790A1 (en) | 2021-10-22 | 2023-04-27 | Sana Biotechnology, Inc. | Methods of engineering allogeneic t cells with a transgene in a tcr locus and associated compositions and methods |
WO2023144303A1 (en) | 2022-01-31 | 2023-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Cd38 as a biomarker and biotarget in t-cell lymphomas |
WO2023156587A1 (en) | 2022-02-18 | 2023-08-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of tcr-deficient car-tregs in combination with anti-tcr complex monoclonal antibodies for inducing durable tolerance |
WO2023183313A1 (en) | 2022-03-22 | 2023-09-28 | Sana Biotechnology, Inc. | Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods |
WO2023198648A1 (en) | 2022-04-11 | 2023-10-19 | Institut National de la Santé et de la Recherche Médicale | Methods for the diagnosis and treatment of t-cell malignancies |
WO2023198874A1 (en) | 2022-04-15 | 2023-10-19 | Institut National de la Santé et de la Recherche Médicale | Methods for the diagnosis and treatment of t cell-lymphomas |
WO2023209568A1 (en) | 2022-04-26 | 2023-11-02 | Novartis Ag | Multispecific antibodies targeting il-13 and il-18 |
WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
WO2023237663A1 (en) | 2022-06-09 | 2023-12-14 | Institut National de la Santé et de la Recherche Médicale | Use of the f359l missense irf4 variant for increasing the stability of regulatory t cells |
WO2024003310A1 (en) | 2022-06-30 | 2024-01-04 | Institut National de la Santé et de la Recherche Médicale | Methods for the diagnosis and treatment of acute lymphoblastic leukemia |
WO2024018003A1 (en) | 2022-07-21 | 2024-01-25 | Institut National de la Santé et de la Recherche Médicale | Extracellular vesicles functionalized with an erv syncitin and uses thereof for cargo delivery |
WO2024018046A1 (en) | 2022-07-22 | 2024-01-25 | Institut National de la Santé et de la Recherche Médicale | Garp as a biomarker and biotarget in t-cell malignancies |
WO2024023283A1 (en) | 2022-07-29 | 2024-02-01 | Institut National de la Santé et de la Recherche Médicale | Lrrc33 as a biomarker and biotarget in cutaneous t-cell lymphomas |
WO2024050450A1 (en) | 2022-08-31 | 2024-03-07 | Gigamune, Inc. | Engineered enveloped vectors and methods of use thereof |
WO2024047110A1 (en) | 2022-08-31 | 2024-03-07 | Institut National de la Santé et de la Recherche Médicale | Method to generate more efficient car-t cells |
WO2024052318A1 (en) | 2022-09-06 | 2024-03-14 | Institut National de la Santé et de la Recherche Médicale | Novel dual split car-t cells for the treatment of cd38-positive hematological malignancies |
WO2024056809A1 (en) | 2022-09-15 | 2024-03-21 | Novartis Ag | Treatment of autoimmune disorders using chimeric antigen receptor therapy |
WO2024079192A1 (en) | 2022-10-12 | 2024-04-18 | Institut National de la Santé et de la Recherche Médicale | Cd81 as a biomarker and biotarget in t-cell malignancies |
WO2024089639A1 (en) | 2022-10-26 | 2024-05-02 | Novartis Ag | Lentiviral formulations |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5270171A (en) * | 1987-03-06 | 1993-12-14 | Boris Cercek | Cancer-associated SCM-recognition factor, preparation and method of use |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4652639A (en) * | 1982-05-06 | 1987-03-24 | Amgen | Manufacture and expression of structural genes |
US5464774A (en) * | 1984-03-05 | 1995-11-07 | The Salk Institute For Biological Studies | Bovine basic fibroblast growth factor |
US5276268A (en) * | 1986-08-23 | 1994-01-04 | Hoechst Aktiengesellschaft | Phosphinothricin-resistance gene, and its use |
US5244797B1 (en) * | 1988-01-13 | 1998-08-25 | Life Technologies Inc | Cloned genes encoding reverse transcriptase lacking rnase h activity |
AP129A (en) * | 1988-06-03 | 1991-04-17 | Smithkline Biologicals S A | Expression of retrovirus gag protein eukaryotic cells |
US5082767A (en) * | 1989-02-27 | 1992-01-21 | Hatfield G Wesley | Codon pair utilization |
US5795737A (en) * | 1994-09-19 | 1998-08-18 | The General Hospital Corporation | High level expression of proteins |
US6114148C1 (en) * | 1996-09-20 | 2012-05-01 | Gen Hospital Corp | High level expression of proteins |
-
1994
- 1994-09-19 US US08324243 patent/US5786464C1/en active Active
-
1995
- 1995-09-08 ES ES95931798T patent/ES2270430T5/es not_active Expired - Lifetime
- 1995-09-08 PT PT95931798T patent/PT781329E/pt unknown
- 1995-09-08 DE DE69535147T patent/DE69535147T3/de not_active Expired - Lifetime
- 1995-09-08 CA CA002200342A patent/CA2200342C/en not_active Expired - Lifetime
- 1995-09-08 AT AT95931798T patent/ATE335078T1/de active
- 1995-09-08 WO PCT/US1995/011511 patent/WO1996009378A1/en active IP Right Grant
- 1995-09-08 AU AU35099/95A patent/AU3509995A/en not_active Abandoned
- 1995-09-08 EP EP95931798A patent/EP0781329B2/de not_active Expired - Lifetime
- 1995-09-08 DK DK95931798.3T patent/DK0781329T4/da active
- 1995-09-08 JP JP8510951A patent/JPH10506278A/ja not_active Withdrawn
- 1995-09-18 ZA ZA957846A patent/ZA957846B/xx unknown
- 1995-09-19 TR TR95/01134A patent/TR199501134A2/xx unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5270171A (en) * | 1987-03-06 | 1993-12-14 | Boris Cercek | Cancer-associated SCM-recognition factor, preparation and method of use |
Non-Patent Citations (5)
Cited By (124)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0851868A4 (de) * | 1995-09-22 | 1998-11-25 | Gen Hospital Corp | Hohe expressionsrate von proteinen |
EP0851868A1 (de) * | 1995-09-22 | 1998-07-08 | The General Hospital Corporation | Hohe expressionsrate von proteinen |
US6534312B1 (en) | 1996-02-22 | 2003-03-18 | Merck & Co., Inc. | Vaccines comprising synthetic genes |
US6114148A (en) * | 1996-09-20 | 2000-09-05 | The General Hospital Corporation | High level expression of proteins |
EP0929564A4 (de) * | 1996-09-20 | 2002-05-22 | Gen Hospital Corp | Hohe expression von proteinen |
EP0929564A1 (de) * | 1996-09-20 | 1999-07-21 | The General Hospital Corporation | Hohe expression von proteinen |
CN1307195C (zh) * | 1996-09-20 | 2007-03-28 | 综合医院公司 | 蛋白的高水平表达 |
WO1998012207A1 (en) * | 1996-09-20 | 1998-03-26 | The General Hospital Corporation | High level expression of proteins |
US6696291B2 (en) | 1997-02-07 | 2004-02-24 | Merck & Co., Inc. | Synthetic HIV gag genes |
WO1998034640A3 (en) * | 1997-02-07 | 1998-11-19 | Merck & Co Inc | Synthetic hiv gag genes |
WO1998034640A2 (en) * | 1997-02-07 | 1998-08-13 | Merck & Co., Inc. | Synthetic hiv gag genes |
US7741079B2 (en) | 1997-07-09 | 2010-06-22 | University of the Queensland | Method of making a genetically modified mammalian cell |
EP1002091A1 (de) * | 1997-07-09 | 2000-05-24 | The University Of Queensland | Nukleinsäuresequenz und verfahren zur selektiven expression eines proteins in einer zielzelle oder -gewebe |
US6489141B1 (en) * | 1997-07-09 | 2002-12-03 | The University Of Queensland | Nucleic acid sequence and methods for selectively expressing a protein in a target cell or tissue |
EP1002091A4 (de) * | 1997-07-09 | 2004-10-13 | Univ Queensland | Nukleinsäuresequenz und verfahren zur selektiven expression eines proteins in einer zielzelle oder -gewebe |
US7790419B2 (en) | 1998-02-17 | 2010-09-07 | Oxford Biomedica (Uk) Ltd. | Antiviral vectors |
EP1790658A3 (de) * | 1998-02-17 | 2007-09-12 | Oxford BioMedica (UK) Limited | Antivirale Vektoren |
JP2002503477A (ja) * | 1998-02-17 | 2002-02-05 | オックスフォード バイオメディカ(ユーケイ)リミテッド | 抗ウイルスベクター |
EP1790658A2 (de) * | 1998-02-17 | 2007-05-30 | Oxford BioMedica (UK) Limited | Antivirale Vektoren |
US6924365B1 (en) | 1998-09-29 | 2005-08-02 | Transkaryotic Therapies, Inc. | Optimized messenger RNA |
EP1535995A1 (de) * | 1998-12-31 | 2005-06-01 | Chiron Corporation | Polynukleotide kodierend für Antigene des HIV Type C ENV Polypeptids, und Verwendungen davon |
WO2000039304A2 (en) * | 1998-12-31 | 2000-07-06 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
WO2000039304A3 (en) * | 1998-12-31 | 2001-01-18 | Chiron Corp | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
US7943375B2 (en) | 1998-12-31 | 2011-05-17 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof |
US7935805B1 (en) | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
US6649409B1 (en) | 1999-03-29 | 2003-11-18 | Statens Serum Institut | Method for producing a nucleotide sequence construct with optimized codons for an HIV genetic vaccine based on a primary, early HIV isolate and synthetic envelope BX08 constructs |
WO2002064799A3 (en) * | 1999-09-28 | 2003-03-27 | Transkaryotic Therapies Inc | Optimized messenger rna |
US6656706B2 (en) | 1999-12-23 | 2003-12-02 | The United States Of America As Represented By The Department Of Health And Human Services | Molecular clones with mutated HIV gag/pol, SIV gag and SIV env genes |
US8076100B2 (en) | 1999-12-23 | 2011-12-13 | The United States Of America As Represented By The Department Of Health And Human Services | Molecular clones with mutated HIV gag/pol, SIV gag and SIV env genes |
WO2001068835A3 (en) * | 2000-03-13 | 2003-01-30 | Aptagen | Method for modifying a nucleic acid |
WO2001068835A2 (en) * | 2000-03-13 | 2001-09-20 | Aptagen | Method for modifying a nucleic acid |
WO2002008417A1 (fr) * | 2000-07-25 | 2002-01-31 | Takeda Chemical Industries, Ltd. | Procede de production d'une proteine de recombinaison |
WO2002042326A1 (en) * | 2000-11-22 | 2002-05-30 | Biota Scientific Management Pty Ltd | A method of expression and agents identified thereby |
WO2002083181A1 (en) | 2001-04-18 | 2002-10-24 | The University Of Queensland | Novel compositions and uses therefor |
US8133494B2 (en) | 2001-07-05 | 2012-03-13 | Novartis Vaccine & Diagnostics Inc | Expression cassettes endcoding HIV-1 south african subtype C modified ENV proteins with deletions in V1 and V2 |
US9598469B2 (en) | 2001-07-05 | 2017-03-21 | Novartis Vaccines And Diagnostics, Inc. | HIV-1 south african subtype C env proteins |
WO2003025003A3 (en) * | 2001-09-20 | 2003-12-04 | Glaxo Group Ltd | Hiv-gag codon-optimised dna vaccines |
WO2003025003A2 (en) * | 2001-09-20 | 2003-03-27 | Glaxo Group Limited | Hiv-gag codon-optimised dna vaccines |
WO2008049782A1 (en) * | 2006-10-24 | 2008-05-02 | Basf Se | Method of increasing gene expression using modified codon usage |
WO2013139911A1 (en) | 2012-03-22 | 2013-09-26 | Crucell Holland B.V. | Vaccine against rsv |
US9125870B2 (en) | 2012-03-22 | 2015-09-08 | Crucell Holland B.V. | Vaccine against RSV |
WO2013139916A1 (en) | 2012-03-22 | 2013-09-26 | Crucell Holland B.V. | Vaccine against rsv |
US9119813B2 (en) | 2012-03-22 | 2015-09-01 | Crucell Holland B.V. | Vaccine against RSV |
US10899800B2 (en) | 2013-04-25 | 2021-01-26 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion RSV F polypeptides |
EP3488864A1 (de) | 2013-04-25 | 2019-05-29 | Janssen Vaccines & Prevention B.V. | Stabilisierte lösliche 'pre-fusion' rsv-f-polypeptide |
US10294279B2 (en) | 2013-06-17 | 2019-05-21 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion RSV F polypeptides |
US10555996B2 (en) | 2014-11-04 | 2020-02-11 | Janssen Vaccines & Prevention B.V. | Therapeutic HPV16 vaccines |
US9701721B2 (en) | 2014-11-04 | 2017-07-11 | Janssen Vaccines & Prevention B.V. | Therapeutic HPV16 vaccines |
US11040096B2 (en) | 2014-11-04 | 2021-06-22 | Janssen Vaccines & Prevention B.V. | Therapeutic HPV16 vaccines |
US10071151B2 (en) | 2014-11-04 | 2018-09-11 | Janssen Vaccines & Prevention B.V. | Therapeutic HPV16 vaccines |
EP3421046A1 (de) | 2014-11-04 | 2019-01-02 | Janssen Vaccines & Prevention B.V. | Therapeutische hpv16-impfstoffe |
US10918740B2 (en) | 2015-04-22 | 2021-02-16 | Curevac Ag | RNA containing composition for treatment of tumor diseases |
US10869935B2 (en) | 2015-04-22 | 2020-12-22 | Curevac Ag | RNA containing composition for treatment of tumor diseases |
US10293058B2 (en) | 2015-04-22 | 2019-05-21 | Curevac Ag | RNA containing composition for treatment of tumor diseases |
US11535665B2 (en) | 2015-05-13 | 2022-12-27 | The Trustees Of The University Of Pennsylvania | AAV-mediated expression of anti-influenza antibodies and methods of use thereof |
US10457708B2 (en) | 2015-07-07 | 2019-10-29 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion RSV F polypeptides |
WO2017005844A1 (en) | 2015-07-07 | 2017-01-12 | Janssen Vaccines & Prevention B.V. | Vaccine against rsv |
US11034731B2 (en) | 2015-07-07 | 2021-06-15 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion RSV F polypeptides |
US11229694B2 (en) | 2015-07-07 | 2022-01-25 | Janssen Vaccines & Prevention B.V. | Vaccine against RSV |
EP3821906A1 (de) | 2015-07-07 | 2021-05-19 | Janssen Vaccines & Prevention B.V. | Impfstoff gegen rsv umfassend eines modifizierten f polypeptide |
US10456462B2 (en) | 2015-07-07 | 2019-10-29 | Janssen Vaccines & Preventions B.V. | Vaccine against RSV |
US10287323B2 (en) | 2015-08-20 | 2019-05-14 | Janssen Vaccines & Prevention B.V. | Therapeutic HPV18 vaccines |
US9790256B2 (en) | 2015-08-20 | 2017-10-17 | Janssen Vaccines & Prevention B.V. | Therapeutic HPV18 vaccines |
US10844096B2 (en) | 2015-08-20 | 2020-11-24 | Janssen Vaccines & Prevention B.V. | Therapeutic HPV18 vaccines |
EP4019044A2 (de) | 2015-09-02 | 2022-06-29 | Janssen Vaccines & Prevention B.V. | Stabilisierte fusionsproteine der virusklasse i |
WO2017037196A1 (en) | 2015-09-02 | 2017-03-09 | Janssen Vaccines & Prevention B.V. | Stabilized viral class i fusion proteins |
EP3808374A1 (de) | 2016-04-05 | 2021-04-21 | Janssen Vaccines & Prevention B.V. | Stabilisiertes losliches prafusioniertes rsv-f-protein zur verwenduing bei der prophylaxe einer rsv infektion |
US10729757B2 (en) | 2016-04-05 | 2020-08-04 | Janssen Vaccines & Prevention B.V. | Vaccine against RSV |
US11155583B2 (en) | 2016-04-05 | 2021-10-26 | Janssen Vaccines & Prevention B.V. | Stabilized soluble pre-fusion RSV F proteins |
US11801297B2 (en) | 2016-04-05 | 2023-10-31 | Janssen Vaccines & Prevention B.V. | Vaccine against RSV |
US11338031B2 (en) | 2016-04-05 | 2022-05-24 | Janssen Vaccines & Prevention B.V. | Vaccine against RSV |
US10517944B2 (en) | 2016-05-02 | 2019-12-31 | Janssen Vaccines & Prevention B.V. | Therapeutic HPV vaccine combinations |
US11759514B2 (en) | 2016-05-30 | 2023-09-19 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion RSV F proteins |
US10953087B2 (en) | 2016-05-30 | 2021-03-23 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion RSV F proteins |
WO2017207480A1 (en) | 2016-05-30 | 2017-12-07 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv f proteins |
WO2017207477A1 (en) | 2016-05-30 | 2017-12-07 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv f proteins |
WO2018087285A1 (en) | 2016-11-10 | 2018-05-17 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Or10h1 antigen binding proteins and uses thereof |
WO2018160573A1 (en) | 2017-02-28 | 2018-09-07 | The Trustees Of The University Of Pennsylvania | Influenza vaccines based on aav vectors |
US11578341B2 (en) | 2017-02-28 | 2023-02-14 | The Trustees Of The University Of Pennsylvania | Compositions useful in treatment of spinal muscular atrophy |
US10786568B2 (en) | 2017-02-28 | 2020-09-29 | The Trustees Of The University Of Pennsylvania | AAV mediated influenza vaccines |
US11827906B2 (en) | 2017-02-28 | 2023-11-28 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus (AAV) clade f vector and uses therefor |
US11229692B2 (en) | 2017-05-17 | 2022-01-25 | Janssen Vaccines & Prevention B.V. | Methods and compositions for inducing protective immunity against RSV infection |
US11229695B2 (en) | 2017-09-15 | 2022-01-25 | Janssen Vaccines & Prevention B.V. | Method for the safe induction of immunity against RSV |
WO2019053109A1 (en) | 2017-09-15 | 2019-03-21 | Janssen Vaccines & Prevention B.V. | METHOD FOR SAFE INDUCTION OF IMMUNITY AGAINST RSV |
US11723989B2 (en) | 2017-11-30 | 2023-08-15 | The Trustees Of The University Of Pennsylvania | Gene therapy for mucopolysaccharidosis IIIB |
US11555206B2 (en) | 2017-11-30 | 2023-01-17 | The Trustees Of The University Of Pennsylvania | Gene therapy for mucopolysaccharidosis IIIA |
EP3508499A1 (de) | 2018-01-08 | 2019-07-10 | iOmx Therapeutics AG | Antikörper zum targeting von, und andere modulatoren von, einem immunglobulingen im zusammenhang mit resistenz gegen antitumor-immunantworten und verwendungen davon |
WO2019134991A1 (en) | 2018-01-08 | 2019-07-11 | Iomx Therapeutics Ag | Antibodies targeting, and other modulators of, an immunoglobulin gene associated with resistance against anti-tumour immune responses, and uses thereof |
WO2019145310A1 (en) | 2018-01-23 | 2019-08-01 | Janssen Vaccines & Prevention B.V. | Influenza virus vaccines and uses thereof |
EP4119154A1 (de) | 2018-01-23 | 2023-01-18 | Janssen Vaccines & Prevention B.V. | Influenzavirenimpfstoffe und verwendungen davon |
WO2020099383A1 (en) | 2018-11-13 | 2020-05-22 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv f proteins |
WO2020216844A1 (en) | 2019-04-25 | 2020-10-29 | Janssen Vaccines & Prevention B.V. | Recombinant influenza antigens |
WO2021005009A1 (en) | 2019-07-05 | 2021-01-14 | Iomx Therapeutics Ag | Antibodies binding igc2 of igsf11 (vsig3) and uses thereof |
WO2022008514A1 (en) | 2019-07-05 | 2022-01-13 | Iomx Therapeutics Ag | Antibodies binding igc2 of igsf11 (vsig3) and uses thereof |
WO2021043869A1 (en) | 2019-09-05 | 2021-03-11 | Janssen Vaccines & Prevention B.V. | Influenza virus vaccines and uses thereof |
WO2021099347A1 (en) | 2019-11-18 | 2021-05-27 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Antibodies targeting, and other modulators of, the cd276 antigen, and uses thereof |
EP3822288A1 (de) | 2019-11-18 | 2021-05-19 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Gegen das cd276-antigen gerichtete antikörper, und andere modulatoren gegen das cd276-antigen, und deren verwendung |
WO2021228842A1 (en) | 2020-05-11 | 2021-11-18 | Janssen Pharmaceuticals, Inc. | Stabilized coronavirus spike protein fusion proteins |
WO2021229448A1 (en) | 2020-05-11 | 2021-11-18 | Janssen Pharmaceuticals, Inc. | Rna replicon encoding a stabilized corona virus spike protein |
WO2021257668A1 (en) | 2020-06-17 | 2021-12-23 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of gene therapy patients |
WO2022008438A1 (en) | 2020-07-06 | 2022-01-13 | Janssen Pharmaceuticals, Inc. | Stabilized corona virus spike protein fusion proteins |
WO2022008027A1 (en) | 2020-07-06 | 2022-01-13 | Iomx Therapeutics Ag | Antibodies binding igv of igsf11 (vsig3) and uses thereof |
WO2022076803A1 (en) | 2020-10-09 | 2022-04-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of fabry disease |
WO2022096536A1 (en) | 2020-11-03 | 2022-05-12 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Target-cell restricted, costimulatory, bispecific and bivalent anti-cd28 antibodies |
EP3992205A1 (de) | 2020-11-03 | 2022-05-04 | Rheinische Friedrich-Wilhelms-Universität Bonn | Verbindung zum binden des sars coronavirus-2 spike-proteins |
WO2022106205A1 (en) | 2020-11-18 | 2022-05-27 | Rheinische Friedrich-Wilhelms-Universität Bonn | Corona virus spike protein binding compounds |
WO2022175477A1 (en) | 2021-02-19 | 2022-08-25 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv fb antigens |
WO2022180007A1 (en) | 2021-02-23 | 2022-09-01 | Janssen Vaccines & Prevention B.V. | Trimer stabilizing hiv envelope protein mutation |
WO2022184845A1 (en) | 2021-03-03 | 2022-09-09 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Bispecific antibodies enhancing cell mediated immune responses |
WO2022207839A2 (en) | 2021-04-01 | 2022-10-06 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion piv3 f proteins |
WO2023047348A1 (en) | 2021-09-24 | 2023-03-30 | Janssen Pharmaceuticals, Inc. | Stabilized corona virus spike protein fusion proteins |
WO2023047349A1 (en) | 2021-09-24 | 2023-03-30 | Janssen Pharmaceuticals, Inc. | Stabilized coronavirus spike protein fusion proteins |
WO2023102517A1 (en) | 2021-12-02 | 2023-06-08 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of fabry disease |
WO2023110618A1 (en) | 2021-12-16 | 2023-06-22 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion hmpv fusion proteins |
WO2023156505A1 (en) | 2022-02-17 | 2023-08-24 | Janssen Vaccines & Prevention B.V. | Trimer stabilizing hiv envelope protein mutations r304v, n302m and t320l |
WO2023196893A1 (en) | 2022-04-06 | 2023-10-12 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating her2 positive metastatic breast cancer and other cancers |
WO2023196892A1 (en) | 2022-04-06 | 2023-10-12 | The Trustees Of The University Of Pennsylvania | Passive immunization with anti- aav neutralizing antibodies to prevent off-target transduction of intrathecally delivered aav vectors |
WO2023217988A1 (en) | 2022-05-12 | 2023-11-16 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion hmpv fusion proteins |
WO2024017682A1 (en) | 2022-07-18 | 2024-01-25 | Janssen Vaccines & Prevention B.V. | Rsv immunogens |
WO2024061753A1 (en) | 2022-09-23 | 2024-03-28 | Janssen Vaccines & Prevention B.V. | Stabilized trimeric class i fusion proteins |
WO2024061757A1 (en) | 2022-09-23 | 2024-03-28 | Janssen Vaccines & Prevention B.V. | Pre-fusion human piv1 f proteins |
WO2024061759A1 (en) | 2022-09-23 | 2024-03-28 | Janssen Vaccines & Prevention B.V. | Stabilized coronavirus s proteins |
WO2024074584A1 (en) | 2022-10-06 | 2024-04-11 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion piv3 f proteins |
WO2024084082A1 (en) | 2022-10-21 | 2024-04-25 | Meatable B.V. | Adipocyte maturation |
Also Published As
Publication number | Publication date |
---|---|
DE69535147T3 (de) | 2011-07-07 |
US5786464A (en) | 1998-07-28 |
EP0781329A1 (de) | 1997-07-02 |
DK0781329T4 (da) | 2011-01-24 |
EP0781329A4 (de) | 1998-11-25 |
ES2270430T3 (es) | 2007-04-01 |
AU3509995A (en) | 1996-04-09 |
TR199501134A2 (tr) | 1996-06-21 |
DK0781329T3 (da) | 2006-12-11 |
CA2200342A1 (en) | 1996-03-28 |
JPH10506278A (ja) | 1998-06-23 |
US5786464C1 (en) | 2012-04-24 |
ATE335078T1 (de) | 2006-08-15 |
ZA957846B (en) | 1997-03-18 |
ES2270430T5 (es) | 2011-05-12 |
EP0781329B1 (de) | 2006-08-02 |
EP0781329B2 (de) | 2010-12-29 |
DE69535147D1 (de) | 2006-09-14 |
DE69535147T2 (de) | 2007-07-05 |
PT781329E (pt) | 2006-12-29 |
CA2200342C (en) | 2009-03-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1996009378A1 (en) | Overexpression of mammalian and viral proteins | |
US6114148A (en) | High level expression of proteins | |
WO1997011086A1 (en) | High level expression of proteins | |
WO1998012207A9 (en) | High level expression of proteins | |
MXPA99002661A (en) | High level expression of proteins | |
JP4336371B2 (ja) | mRNAの阻害/不安定領域の除去方法 | |
KR100553510B1 (ko) | 항융합형성 펩티드의 재조합 제조 방법 | |
KR20220113442A (ko) | 입자 전달 시스템 | |
EP1156112B1 (de) | Synthetische Gene für gagpol und deren Verwendungen | |
Rhim et al. | Exon2 of HIV-2 Tat contributes to transactivation of the HIV-2 LTR by increasing binding affinity to HIV-2 TAR RNA | |
Carlsdottir | Delineation of sequences required for the packaging of genomic RNA into HIV-1 virions |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AU BG BR BY CA CN CZ FI HU JP KR MX NO NZ PL RO RU SG SI UA |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 1995931798 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2200342 Country of ref document: CA Ref country code: CA Ref document number: 2200342 Kind code of ref document: A Format of ref document f/p: F |
|
WWP | Wipo information: published in national office |
Ref document number: 1995931798 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 1995931798 Country of ref document: EP |