WO1996008245A1 - Pansement a usage externe - Google Patents
Pansement a usage externe Download PDFInfo
- Publication number
- WO1996008245A1 WO1996008245A1 PCT/JP1995/001798 JP9501798W WO9608245A1 WO 1996008245 A1 WO1996008245 A1 WO 1996008245A1 JP 9501798 W JP9501798 W JP 9501798W WO 9608245 A1 WO9608245 A1 WO 9608245A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- parts
- menthol
- patch
- product name
- styrene
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Definitions
- the present invention relates to an external patch containing an anti-inflammatory drug having a carboxylic acid group in the molecule, 1-menthol and a metal salt of fatty acid. More specifically, an anti-inflammatory drug having a carboxylic acid group in the molecule and 1-menthol as a solubilizer, a pharmaceutically active ingredient or a cooling agent, and a fatty acid metal salt as a stabilizer or esterification inhibitor of the anti-inflammatory drug.
- the present invention relates to a novel external patch contained. Background art
- Japanese Patent Application Laid-Open No. 59-2287819 discloses non-steroids. It has been disclosed that an antiphlogistic analgesic is contained in an acrylic pressure-sensitive adhesive on a composite of a nonwoven fabric and a film, and an attempt is made to administer the same.
- Japanese Patent Laid-Open Publication No. Sho 60-139396 discloses an attempt to incorporate ketoprofen into a pressure-sensitive adhesive comprising polyisobutylenenobarafinnorosin-modified glycerin ester and absorb it transdermally. Japanese Patent Application Laid-Open No.
- JP-A-64-42020 discloses an attempt to administer a non-steroid anti-inflammatory analgesic having a carboxyl group using an oleaginous base. In each case, the drug release and transdermal absorption are not yet sufficient, and the emergence of even better preparations is desired.
- the present inventors disclosed an attempt to significantly improve transdermal absorbability by containing a non-steroidal anti-inflammatory drug such as ketobrophene, a rosin ester derivative and 1-menthol as a dissolving agent, and published a document (WO) 93- The disclosure was made in Japanese Patent Publication No. 046767.
- An object of the present invention is to obtain an external patch having the stability of an anti-inflammatory drug while maintaining the release of the active ingredient and transdermal absorption. Disclosure of the invention
- the present inventors have conducted intensive studies to achieve the above object, and as a result, in the formulation of a combination of an anti-inflammatory drug having a carboxylic acid group in the molecule and 1-menthol used as a solubilizer, a medicinal ingredient or a cooling agent.
- a fatty acid metal salt can greatly improve the stability or the effect of preventing anti-inflammatory drugs from esterification while maintaining high release and transdermal absorption.
- the present invention relates to an external patch comprising an essential component containing an adhesive.
- a feature of the present invention is that a fatty acid metal salt, which is recognized by those skilled in the art as a lubricant for baby powder and antiperspirant cosmetics, is used as a stabilizing agent or an esterification inhibitor for the external patch of the present invention. It is in.
- an anti-inflammatory drug having a carboxylic acid group in the molecule and 1-menthol used as a solubilizer, a medicinal ingredient or a cooling agent at a specific ratio a mixture of the anti-inflammatory drug and 1-menthol in the base becomes amorphous. It dissolves without crystallization in the base material and exhibits high release properties and, consequently, high transdermal absorbability.
- both the anti-inflammatory drug and 1-menthol react to form 1-menthol ester.
- the present inventors can achieve a high level by inhibiting only the esterification reaction while maintaining high solubility, release properties and transdermal absorption in the base of the anti-inflammatory drug. Successfully gained stability. Stabilizes fatty acid metal salts in external patches Alternatively, the fact that the compound was incorporated as an esterification inhibitor was achieved by the present inventors for the first time, and is a novel thing which has not been described in conventionally known documents.
- Examples of the fatty acid of the fatty acid metal salt used in the present invention include long-chain fatty acids such as pendecilenic acid, stearic acid, panolemitic acid, myristic acid, and lauric acid. Salts and sodium salts are preferred. Specific examples include, for example, zinc perdecylenate, zinc stearate, calcium stearate, aluminum stearate, magnesium stearate, sodium stearate, zinc palmitate, zinc myristate, magnesium myristate, sodium laurate And zinc laurate are preferred, and these may be used alone or in combination of two or more. Among them, zinc stearate is particularly preferred.
- fatty acid gold salts are particularly preferable as long as they are listed in Cosmetic Ingredients Standards, Japanese Pharmacopoeia, BP (UK Pharmacopoeia), USP (USP), and EP (European Pharmacopoeia).
- the amount of the fatty acid metal salt to be added is preferably 0.5 to 10% by weight in the base material. If the amount is less than 0.5% by weight, the effect of preventing esterification is hardly obtained, and accordingly, the transdermal absorption property is increased. And it greatly impairs the pharmacological activity. If the content is more than 10% by weight, the stability of the base is deteriorated, and the release and transdermal absorption of the drug from the base or the pharmacological activity is greatly impaired.
- the pressure-sensitive adhesive to be used as the external patch is composed of an elastic material, a tackifier and an emulsifier, and can be appropriately selected from known ones in consideration of skin / 1 safety, adhesion to skin, and the like.
- an elastic material for example, natural rubbers, synthetic rubbers, silicones, acrylics, etc. are used as the elastic body.
- synthetic rubbers styrene-isoprene-styrene block copolymers are preferred.
- Styrene-isoprene-styrene block copolymers are available, for example, from Force Reflex TR-1107, TR-1111, TR-1112 or TR-1117 (trade name, Seal Chemical Co., Ltd.) ), JSRSIS—500 or 5002 (trade name, manufactured by Nippon Synthetic Rubber Co., Ltd.), Quintac 3530 or 3421 (trade name, manufactured by Nippon Zeon Co., Ltd.) , Sorprene 4 2 8 (trade name, Philippe Petroleum Co., Ltd.).
- a styrene-isoprene-styrene block copolymer is preferably used as the base polymer as described above, but it may be used in combination with another polymer, for example, polyisobutylene, polyisoprene, or the like.
- the tackifier include polyterpene resin, petroleum resin, rosin, hydrogenated rosin, resin, hydrogenated rosin ester, and oil-soluble phenol resin. Among them, rosin and hydrogenated rosin ester are preferable. Rosin ester derivatives are obtained by esterifying various kinds of rosin and hydrogenating or purifying it.
- plasticizers such as styrene-isoprene-styrene block copolymers and tackifiers such as rosin ester derivatives are plasticized and degraded to maintain proper adhesion to skin.
- Almond oil, olive oil, camellia oil, persic oil, laccase oil, oleic acid, liquid paraffin, and the like are used as the emulsifying agent. Among them, liquid paraffin is particularly preferred.
- the styrene-isoprene-styrene block copolymer, the rosin ester derivative and the liquid paraffin are preferably blended, and the blending ratio is 100% in the styrene-isoprene-styrene block copolymer rosin ester derivative liquid paraffin.
- Z 15 to 300 is 100 to 500, and in this range, the adhesive is suitable for leather and S.
- Anti-inflammatory drugs having a carboxylic acid group in the molecule include, for example, salicylic acid, acetylsalicylic acid, flufenamic acid, mefenamic acid, acemethasin, alclofenac, diclofenac, ibuprofen, indomethacin, ketoprofun, ketoprofen, sulindac, tolmetin, tolmetin Nzarrit, Penicillamine, Oxaprozin, Diflunisal, Fenbufen, Fentiazac, Flurbiprof , Naproxen, pranoprofen, tiaprofen, suprofen, verbinac, ketorolac, oxaprozin, etodolac, zaltoprofen, etc.
- anti-inflammatory drugs having an acetic acid group or a propionic acid group such as ketoprofen, indomethacin, flurbiprofen, ketorolac, and felbinac, are particularly preferable from the viewpoint of preventing esterification.
- the compounding amount is not particularly limited, but it is used as an anti-inflammatory agent within a range of 0.1 to 10% by weight, preferably 0.3 to 9% by weight, more preferably 0.5 to 8% by weight. It is desirable.
- the release of an effective amount contributing to therapy as anti-inflammatory agents, Ri by point utilization 1 0 0 ⁇ 5 0 0 g Z cm 2 is preferred.
- menthol is used for the purpose of dissolving an anti-inflammatory drug, a medicinal component or an auxiliary medicinal component, or a cooling agent for a cooling effect. It is used in a combination that serves all purposes or in a formulation that suits each purpose.
- the amount of 1-menthol used when used as a solubilizer for an anti-inflammatory drug, is somewhat increased, so that the possibility of esterification tends to be higher. Therefore, the use of a fatty acid metal salt is more effective when used as a solubilizer.
- Distribution stage of the 1 Ichime Ntoru is from 0.1 to 2 0 weight 0/0, is used preferably from 0.5 to 1 5% by weight, more preferably in the range of from 1.0 to 1 2% .
- the inhibitory effect on the prevention of esterification is greatly affected by the ratio of the weight ratio of the anti-inflammatory drug to 1-menthol and the fatty acid metal salt, and the weight ratio of 1-menthol is 0.1 to 1 for the anti-inflammatory drug.
- the ratio of 1 to 10 and preferably 0.5 to 5 and the ratio of fatty acid metal salt in the ratio of 0.1 to 7 and preferably 0.3 to 5 can suppress the prevention of esterification. The effect is greater.
- the effect of preventing esterification tends to be remarkable by adopting a formulation in an anhydrous base, and an externally applied patch having a substantially anhydrous formulation is preferred.
- a hardener comprising an anhydrous formulation is the most preferred formulation.
- the external patch of the present invention can be easily produced by a conventionally known production method.
- a mixture such as a kneader or a mixer is used at 120 to 160 ° C. Heat-mix the styrene-isoprene-styrene block copolymer, rosin ester derivative, and fatty acid metal salt, then add and mix the anti-inflammatory drug and 1-menthol and spread them directly on the support, or temporarily release them. After spreading on the applied paper or film, a desired support may be covered and transferred by pressure bonding.
- the external patch of the present invention is an anti-inflammatory drug having a carboxylic acid group in the molecule which is the main drug.
- FIG. 1 is a graph showing the results of a hairless mouse skin permeation test. BEST MODE FOR CARRYING OUT THE INVENTION
- Ketoprofen 0.5 part A patch was prepared with this formulation according to the above-mentioned production method. That is, using a blender as a mixer, styrene-isoprene-styrene block copolymer, zinc stearate, softener and rosin ester derivative are heated and mixed at 120-160 ° C, and then non-steroid anti-inflammatory analgesia. The drug (ketoprofen) and 1-menthol are added, mixed, spread on a PET film that has been subjected to a release treatment, and then covered with a polyester cloth (PET) and cut into a desired size. Antiphlogistic analgesic patch.
- Example 2 Example 2
- Ketoprofen 3.0 parts A patch was prepared with this formulation according to the production method of Example 1 above.
- Styrene-isoprene-styrene block copolymer 7.0 parts (Product name: CALIFLEX TR-1 1 0 7)
- Liquid paraffin 44.0 parts Zinc stearate 10.0 parts Rosin ester derivative 20.0 parts
- Styrene-isoprene-styrene block copolymer 30.0 parts (trade name: CARIFLEX TR—111)
- Liquid paraffin 48.5 parts Zinc stearate 2.0 parts Rosin ester derivatives 22.5 parts
- Liquid paraffin 45.0 parts Zinc stearate 2.0 parts Rosin ester derivatives 21.0 parts
- Styrene-isoprene-styrene block copolymer 18.0 parts
- Styrene-isoprene-styrene block copolymer 17.5 parts (trade name: CARIFLEX TR— 1 1 1 1) Polyisobutylene (manufactured by Exxon Chemical Co., Ltd.) 9.5 parts Liquid paraffin 50.0 parts Zinc stearate 2.0 parts Rosin ester derivatives 15.0 parts
- Ketoprofen 2.0 parts A patch was prepared with this formulation according to the production method of Example 1 above.
- Ketoprofen 3.0 parts A patch was prepared with this formulation according to the production method of Example 1 described above.
- Styrene-isoprene-styrene block copolymer 18.0 parts
- Zinc myristate 2.5 parts Zinc stearate 1.0 part
- Styrene-isoprene-styrene block copolymer 30.0 parts (trade name: Califlex TR-1 107)
- Ketoprofen 7.0 parts A patch was prepared with this formulation according to the production method of Example 1 described above.
- a patch was produced in the same manner as in Example 4, except that zinc stearate was not blended.
- Comparative Example 2 A patch was produced in exactly the same formulation and production method as in Example 17 except that zinc stearate was not mounted.
- a patch was produced in exactly the same formulation and production method as in Example 8 except that zinc stearate was not blended.
- a patch was produced in exactly the same manner as in Example 19 except that zinc stearate was not blended.
- a patch was produced in the same manner as in Example 20, except that zinc stearate was not blended.
- a patch was produced in the same manner as in Example 4 except that 1-menthol was not blended.
- Styrene-isoprene-styrene block copolymer 18.0 parts
- Ketoprofen 2.0 parts A patch was prepared according to Example 21 except that zinc stearate was changed to 0.2 parts.
- Ketoprofen 2.0 parts A patch was prepared according to Example 21 except that zinc stearate was changed to 11.0 parts.
- Acrylic adhesive Nisset PE-300 (trade name, manufactured by Nippon Carbide Industry Co., Ltd.) 3 parts of ketoprofen were added to 97 parts of solid content and mixed, and spread on a polyester film that had been subjected to release treatment. Thereafter, the patch was covered with a support and cut into a desired size to produce a patch.
- a patch was produced using exactly the same formulation and production method as in Reference Example 1 except that ketoprofen was changed to flurbiprofen.
- Example 4 17 21 containing zinc stearate which is a fatty acid metal salt
- the ratio of zinc stearate not added was 15 and that of zinc stearate 0.2 part by weight was added.
- Comparative Example 8 containing 11 parts by weight of zinc stearate it exhibited a remarkable inhibitory effect on 1-menthol esterification, and the stability of the drug contained was extremely high.
- Test example 2 (dissolution stability test) Using each of the patches of Examples 4, 17 to 21 and Comparative Examples 6 to 8, a dissolution stability test was performed for 5 to 1 month storage. The results are shown in Table 2.
- Test example 3 Hapless mouse skin penetration test
- Examples 4 and 17 to 21 are clearly superior in drug release and transdermal absorption (comparative permeation amount) in comparison with Comparative Examples 6 to 8 and Reference Examples 1 and 2.
- Industrial applicability The present invention makes it possible to significantly suppress the ester formed by a chemical reaction between an anti-inflammatory drug having a carboxylic acid group in the molecule and 1-menthol by adding a fatty acid metal salt. .
- ester by-products that are not medicinal components is significantly suppressed, and the percutaneous absorption and pharmacological activity of the anti-inflammatory drug, which is the main drug, have been greatly improved.
- the release of the drug from the base was improved. It is very useful in the pharmaceutical industry to provide an external patch preparation with improved safety in use as a medicament for anti-inflammatory diseases that exerts the intended excellent therapeutic effect without any effect. .
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Botany (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95930730A EP0781553B1 (en) | 1994-09-16 | 1995-09-11 | Patch for external use |
JP51005696A JP3238409B2 (ja) | 1994-09-16 | 1995-09-11 | 外用貼付剤 |
DE69535737T DE69535737T2 (de) | 1994-09-16 | 1995-09-11 | Pflaster zur externen anwendung |
KR1019970701676A KR100191062B1 (ko) | 1994-09-16 | 1995-09-11 | 외용첩부제 |
CA002200068A CA2200068C (en) | 1994-09-16 | 1995-09-11 | A preparation for external use and a patch having the preparation attached thereto |
ES95930730T ES2304783T3 (es) | 1994-09-16 | 1995-09-11 | Parche de uso externo. |
US08/793,692 US5869087A (en) | 1994-09-16 | 1995-09-11 | Patch having a preparation for external use attached thereto |
AU34000/95A AU685673B2 (en) | 1994-09-16 | 1995-09-11 | Patch for external use |
HK97102612A HK1001372A1 (en) | 1994-09-16 | 1997-12-23 | Patch for external use |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6/248814 | 1994-09-16 | ||
JP24881494 | 1994-09-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996008245A1 true WO1996008245A1 (fr) | 1996-03-21 |
Family
ID=17183812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1995/001798 WO1996008245A1 (fr) | 1994-09-16 | 1995-09-11 | Pansement a usage externe |
Country Status (14)
Country | Link |
---|---|
US (1) | US5869087A (ja) |
EP (1) | EP0781553B1 (ja) |
JP (1) | JP3238409B2 (ja) |
KR (1) | KR100191062B1 (ja) |
CN (1) | CN1081028C (ja) |
AT (1) | ATE390132T1 (ja) |
AU (1) | AU685673B2 (ja) |
CA (1) | CA2200068C (ja) |
DE (1) | DE69535737T2 (ja) |
ES (1) | ES2304783T3 (ja) |
HK (1) | HK1001372A1 (ja) |
PT (1) | PT781553E (ja) |
TW (1) | TW416855B (ja) |
WO (1) | WO1996008245A1 (ja) |
Cited By (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08319234A (ja) * | 1995-05-24 | 1996-12-03 | Yuutoku Yakuhin Kogyo Kk | 経皮吸収型消炎鎮痛貼付剤 |
WO1998024423A1 (fr) * | 1996-12-06 | 1998-06-11 | Hisamitsu Pharmaceutical Co., Inc. | Timbre contenant du felbinac |
JP2001039864A (ja) * | 1999-07-30 | 2001-02-13 | Hisamitsu Pharmaceut Co Inc | フェルビナク含有貼付剤 |
WO2001078690A1 (fr) | 2000-04-18 | 2001-10-25 | Hisamitsu Pharmaceutical Co., Inc. | Piece contenant un agent anti-inflammatoire |
JP2001302502A (ja) * | 2000-04-27 | 2001-10-31 | Saitama Daiichi Seiyaku Kk | インドメタシン貼付剤 |
EP1181911A1 (en) | 2000-08-23 | 2002-02-27 | Kao Corporation | Steam generating cell with adhesive application layer |
US6620430B2 (en) | 1996-12-06 | 2003-09-16 | Hisamitsu Pharmaceutical Co., Inc. | Plaster containing felbinac |
JP2003286161A (ja) * | 2002-03-29 | 2003-10-07 | Kobayashi Pharmaceut Co Ltd | フェニル酢酸誘導体類及びメントール類を含有する消炎鎮痛剤及び消炎鎮痛作用増強方法 |
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JPH08319234A (ja) * | 1995-05-24 | 1996-12-03 | Yuutoku Yakuhin Kogyo Kk | 経皮吸収型消炎鎮痛貼付剤 |
WO1998024423A1 (fr) * | 1996-12-06 | 1998-06-11 | Hisamitsu Pharmaceutical Co., Inc. | Timbre contenant du felbinac |
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JP2001039864A (ja) * | 1999-07-30 | 2001-02-13 | Hisamitsu Pharmaceut Co Inc | フェルビナク含有貼付剤 |
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WO2001078690A1 (fr) | 2000-04-18 | 2001-10-25 | Hisamitsu Pharmaceutical Co., Inc. | Piece contenant un agent anti-inflammatoire |
JP4625157B2 (ja) * | 2000-04-27 | 2011-02-02 | ニプロパッチ株式会社 | インドメタシン貼付剤 |
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JPWO2004082672A1 (ja) * | 2003-03-18 | 2006-06-22 | 久光製薬株式会社 | 非ステロイド系消炎鎮痛剤含有貼付剤 |
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JP2006151886A (ja) * | 2004-11-30 | 2006-06-15 | Hisamitsu Pharmaceut Co Inc | 角質剥離が少ない貼付剤 |
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JP2010090099A (ja) * | 2008-10-07 | 2010-04-22 | Hisamitsu Pharmaceut Co Inc | エステル化抑制剤及びエステル化抑制方法 |
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Also Published As
Publication number | Publication date |
---|---|
ES2304783T3 (es) | 2008-10-16 |
HK1001372A1 (en) | 1998-06-19 |
US5869087A (en) | 1999-02-09 |
CA2200068A1 (en) | 1996-03-21 |
TW416855B (en) | 2001-01-01 |
EP0781553B1 (en) | 2008-03-26 |
KR100191062B1 (ko) | 1999-06-15 |
JP3238409B2 (ja) | 2001-12-17 |
EP0781553A1 (en) | 1997-07-02 |
ATE390132T1 (de) | 2008-04-15 |
KR970705986A (ko) | 1997-11-03 |
CN1158083A (zh) | 1997-08-27 |
DE69535737T2 (de) | 2009-04-09 |
CN1081028C (zh) | 2002-03-20 |
EP0781553A4 (en) | 2005-04-27 |
PT781553E (pt) | 2008-04-09 |
DE69535737D1 (de) | 2008-05-08 |
AU3400095A (en) | 1996-03-29 |
CA2200068C (en) | 2005-01-11 |
AU685673B2 (en) | 1998-01-22 |
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