WO1996005176A1 - Compose de pyridazine condense - Google Patents

Compose de pyridazine condense Download PDF

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Publication number
WO1996005176A1
WO1996005176A1 PCT/JP1995/001575 JP9501575W WO9605176A1 WO 1996005176 A1 WO1996005176 A1 WO 1996005176A1 JP 9501575 W JP9501575 W JP 9501575W WO 9605176 A1 WO9605176 A1 WO 9605176A1
Authority
WO
WIPO (PCT)
Prior art keywords
pyridazine compound
cgmp
inhibitory effect
pde
fused pyridazine
Prior art date
Application number
PCT/JP1995/001575
Other languages
English (en)
French (fr)
Inventor
Nobuhisa Watanabe
Yasuhiro Kabasawa
Yasutaka Takase
Fumihiro Ozaki
Keiji Ishibashi
Kazuki Miyazaki
Masayuki Matsukura
Shigeru Souda
Kazutoshi Miyake
Hiroki Ishihara
Kohtaro Kodama
Hideyuki Adachi
Original Assignee
Eisai Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002173493A priority Critical patent/CA2173493C/en
Application filed by Eisai Co., Ltd. filed Critical Eisai Co., Ltd.
Priority to EP95927990A priority patent/EP0722936B1/en
Priority to AU31919/95A priority patent/AU705229B2/en
Priority to DE69533057T priority patent/DE69533057T2/de
Priority to AT95927990T priority patent/ATE267174T1/de
Priority to KR1019960701845A priority patent/KR100189865B1/ko
Priority to US08/619,621 priority patent/US5849741A/en
Priority to NZ290952A priority patent/NZ290952A/en
Priority to RU96115026A priority patent/RU2128175C1/ru
Priority to HU9600933A priority patent/HU219864B/hu
Publication of WO1996005176A1 publication Critical patent/WO1996005176A1/ja
Priority to FI961510A priority patent/FI111841B/fi
Priority to NO19961397A priority patent/NO309378B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
PCT/JP1995/001575 1994-08-09 1995-08-08 Compose de pyridazine condense WO1996005176A1 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
KR1019960701845A KR100189865B1 (ko) 1994-08-09 1995-08-08 축합 피리다진계 화합물
EP95927990A EP0722936B1 (en) 1994-08-09 1995-08-08 Fused pyridazine compound
AU31919/95A AU705229B2 (en) 1994-08-09 1995-08-08 Fused pyridazine compound
DE69533057T DE69533057T2 (de) 1994-08-09 1995-08-08 Kondensierte pyridazinverbindungen
AT95927990T ATE267174T1 (de) 1994-08-09 1995-08-08 Kondensierte pyridazinverbindungen
CA002173493A CA2173493C (en) 1994-08-09 1995-08-08 Fused pyridazine compounds
US08/619,621 US5849741A (en) 1994-08-09 1995-08-08 Fused pyridazine compounds
HU9600933A HU219864B (hu) 1994-08-09 1995-08-08 cGMP-PDE inhibitor kondenzált piridazinszármazékok és alkalmazásuk
RU96115026A RU2128175C1 (ru) 1994-08-09 1995-08-08 Конденсированный пиридазин или его фармакологически приемлемая соль, средство, проявляющее ингибирующую активность в отношении циклической гмф- фосфодиэстеразы
NZ290952A NZ290952A (en) 1994-08-09 1995-08-08 Phthalazine derivatives optionally substituted in position-1 by (generally benzyl) amino groups
FI961510A FI111841B (fi) 1994-08-09 1996-04-03 Kondensoidut pyridatsiiniyhdisteet ja niiden käyttö valmistettaessa lääkkeitä
NO19961397A NO309378B1 (no) 1994-08-09 1996-04-09 Kondenserte pyridazinforbindelser og anvendelser derav ved fremstilling av medikamenter

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP6/187128 1994-08-09
JP18712894 1994-08-09
JP31633794 1994-12-20
JP6/316337 1994-12-20

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/161,946 Division US6218392B1 (en) 1994-08-09 1998-09-29 Fused pyridazine compounds

Publications (1)

Publication Number Publication Date
WO1996005176A1 true WO1996005176A1 (fr) 1996-02-22

Family

ID=26504157

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1995/001575 WO1996005176A1 (fr) 1994-08-09 1995-08-08 Compose de pyridazine condense

Country Status (15)

Country Link
US (2) US5849741A (ja)
EP (1) EP0722936B1 (ja)
KR (1) KR100189865B1 (ja)
CN (1) CN1151136C (ja)
AT (1) ATE267174T1 (ja)
AU (1) AU705229B2 (ja)
CA (1) CA2173493C (ja)
DE (1) DE69533057T2 (ja)
ES (1) ES2224130T3 (ja)
FI (1) FI111841B (ja)
HU (1) HU219864B (ja)
MX (1) MX9601310A (ja)
NO (1) NO309378B1 (ja)
NZ (1) NZ290952A (ja)
WO (1) WO1996005176A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042452A1 (fr) 1998-02-19 1999-08-26 Eisai Co., Ltd. Derives de phtalazine et remedes contre la dyserection
AU722710B2 (en) * 1996-08-20 2000-08-10 Eisai Co. Ltd. Remedies for erectile dysfunction containing fused pyridazine compounds
US6576644B2 (en) 2000-09-06 2003-06-10 Bristol-Myers Squibb Co. Quinoline inhibitors of cGMP phosphodiesterase
US11618751B1 (en) 2022-03-25 2023-04-04 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331543B1 (en) * 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
PT971901E (pt) * 1997-01-15 2003-07-31 Altana Pharma Ag Ftalazinonas
CO4950519A1 (es) * 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
ZA9810766B (en) 1997-11-28 1999-05-25 Mochida Pharm Co Ltd Novel compounds having cgmp-pde inhibitory activity
US6380196B1 (en) 1997-12-15 2002-04-30 Byk Gulden Lomberg Chemische Fabrik Gmbh Dihydrobenzofurans
ITMI981670A1 (it) 1998-07-21 2000-01-21 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
IT1302677B1 (it) 1998-10-15 2000-09-29 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
IT1303272B1 (it) 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
WO2000056719A1 (en) * 1999-03-22 2000-09-28 Bristol-Myers Squibb Company FUSED PYRIDOPYRIDAZINE INHIBITORS OF cGMP PHOSPHODIESTERASE
PT1165085E (pt) 1999-03-30 2006-10-31 Novartis Ag Derivados de ftalazina para tratar doencas inflamatorias
DE19921567A1 (de) * 1999-05-11 2000-11-16 Basf Ag Verwendung von Phthalazine-Derivaten
AR025068A1 (es) * 1999-08-10 2002-11-06 Bayer Corp Pirazinas sustituidas y piridazinas fusionadas, composicion farmaceutica que las comprenden, uso de dichos compuestos para la manufactura de un medicamentocon actividad inhibidora de angiogenesis
MY123528A (en) 1999-09-16 2006-05-31 Mitsubihsi Tanabe Pharma Corp Aromatic nitrogen-containing 6-membered cyclic compounds.
US6689883B1 (en) 1999-09-28 2004-02-10 Bayer Pharmaceuticals Corporation Substituted pyridines and pyridazines with angiogenesis inhibiting activity
GT200000158A (es) * 1999-09-28 2002-03-16 Piridinas y piridacinas sustituidas con actividad de inhibicion de angiogenesis.
AU7547900A (en) 1999-10-11 2001-04-23 Pfizer Inc. 5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)- dihydropyrazolo(4,3-d)pyrimidin-7-ones as phosphodiesterase inhibitors
DE19963607B4 (de) * 1999-12-23 2005-12-15 Schering Ag Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen
US7977333B2 (en) 2000-04-20 2011-07-12 Bayer Healthcare Llc Substituted pyridines and pyridazines with angiogenesis inhibiting activity
US7273868B2 (en) 2000-04-28 2007-09-25 Tanabe Seiyaku Co., Ltd. Pyrazine derivatives
KR100711042B1 (ko) 2000-04-28 2007-04-24 다나베 세이야꾸 가부시키가이샤 환상 화합물
US6903101B1 (en) 2000-08-10 2005-06-07 Bayer Pharmaceuticals Corporation Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity
EP1364950A4 (en) 2001-02-26 2005-03-09 Tanabe Seiyaku Co PYRIDOPYRIMIDINE OR NAPHTHYRIDINE DERIVATIVE
GB0111078D0 (en) * 2001-05-04 2001-06-27 Novartis Ag Organic compounds
SI1427420T1 (sl) * 2001-09-12 2006-12-31 Novartis Ag Uporaba kombinacije, ki vsebuje 4-piridilmetilftalazine za zdravljenje raka
WO2003022282A1 (en) * 2001-09-12 2003-03-20 Novartis Ag Use of 4-pyridylmethylphthalazines for cancer treatment
BR0313724A (pt) * 2002-08-13 2005-06-28 Warner Lambert Co Derivados de azaisoquinolina como inibidores de metaloproteinase de matriz
ITMI20022738A1 (it) * 2002-12-23 2004-06-24 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4.
US7759337B2 (en) * 2005-03-03 2010-07-20 Amgen Inc. Phthalazine compounds and methods of use
US8506934B2 (en) 2005-04-29 2013-08-13 Robert I. Henkin Methods for detection of biological substances
EP2218442A1 (en) 2005-11-09 2010-08-18 CombinatoRx, Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
WO2007100880A1 (en) * 2006-02-28 2007-09-07 Amgen Inc. Cinnoline and quinazoline derivates as phosphodiesterase 10 inhibitors
US8293489B2 (en) 2007-01-31 2012-10-23 Henkin Robert I Methods for detection of biological substances
PE20090188A1 (es) 2007-03-15 2009-03-20 Novartis Ag Compuestos heterociclicos como moduladores de la senda de hedgehog
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
US8580801B2 (en) * 2008-07-23 2013-11-12 Robert I. Henkin Phosphodiesterase inhibitor treatment
US8772481B2 (en) 2008-10-10 2014-07-08 Amgen Inc. Aza- and diaza-phthalazine compounds as P38 map kinase modulators and methods of use thereof
US8497269B2 (en) 2008-10-10 2013-07-30 Amgen Inc. Phthalazine compounds as p38 map kinase modulators and methods of use thereof
CN102443031B (zh) * 2011-09-20 2014-03-05 山东大学 一种c-di-GMP的分离纯化方法
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
EP2903619B1 (en) 2012-10-05 2019-06-05 Robert I. Henkin Phosphodiesterase inhibitors for treating taste and smell disorders
CN106233141B (zh) 2014-02-18 2018-08-21 罗伯特·I·汉金 用于诊断和治疗味觉或嗅觉的损失和/或失真的方法和组合物
RU2649140C2 (ru) * 2015-04-20 2018-03-30 государственное бюджетное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения Российской Федерации (ГБОУ ВПО ПГФА Минздрава России) 2-гидрокси-4-оксо-4-(4'-хлорфенил)-бут-2-еноат 4-метил-2-пиридиламмония, обладающий прямым антикоагулянтным действием
US11319319B1 (en) * 2021-04-07 2022-05-03 Ventus Therapeutics U.S., Inc. Compounds for inhibiting NLRP3 and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3494921A (en) * 1968-08-29 1970-02-10 Dow Chemical Co 1,4-disubstituted pyridazino(4,5-d) pyridazines
JPH02129180A (ja) * 1988-11-04 1990-05-17 Morishita Pharmaceut Co Ltd １−（１ｈ−イミダゾール−１−イル）フタラジン誘導体
JPH06135938A (ja) * 1991-09-26 1994-05-17 Mitsubishi Kasei Corp ３，６−ジ置換ピリダジン誘導体
WO1994020508A1 (en) * 1993-03-08 1994-09-15 Eisai Co., Ltd. Phosphonic acid derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794964A (fr) * 1972-02-04 1973-08-02 Bristol Myers Co Nouveaux agents hypotenseurs et procede pour les preparer
US3971783A (en) * 1973-03-07 1976-07-27 Pfizer Inc. 4-Aminoquinazoline derivatives as cardiac stimulants
GB1417029A (en) * 1973-03-07 1975-12-10 Pfizer Ltd Quinazoline-derived amines
CA1309556C (en) * 1987-06-09 1992-10-27 Masayuki Kokubo 4h-3,1-benzoxazin-4-one compounds and pharmaceutical composition thereoffor the inhibition of serine proteases
JPH0348664A (ja) * 1989-07-14 1991-03-01 Doumiyaku Kouka Kenkyu Shiyoureikai フタラジノン誘導体
JPH03106874A (ja) * 1989-09-20 1991-05-07 Morishita Pharmaceut Co Ltd ４―ピリジル―１（２ｈ）フタラジノン
ATE115136T1 (de) * 1990-03-30 1994-12-15 Mitsubishi Chem Ind 4-phenylphthalazin-derivate.
JP2657760B2 (ja) * 1992-07-15 1997-09-24 小野薬品工業株式会社 ４−アミノキナゾリン誘導体およびそれを含有する医薬品
JP3106874B2 (ja) 1993-09-29 2000-11-06 松下電器産業株式会社 円盤記録再生装置

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3494921A (en) * 1968-08-29 1970-02-10 Dow Chemical Co 1,4-disubstituted pyridazino(4,5-d) pyridazines
JPH02129180A (ja) * 1988-11-04 1990-05-17 Morishita Pharmaceut Co Ltd １−（１ｈ−イミダゾール−１−イル）フタラジン誘導体
JPH06135938A (ja) * 1991-09-26 1994-05-17 Mitsubishi Kasei Corp ３，６−ジ置換ピリダジン誘導体
WO1994020508A1 (en) * 1993-03-08 1994-09-15 Eisai Co., Ltd. Phosphonic acid derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KORMENDY, K. et al., "Pyridazines condensed with a hetero ring. II. Aminopyrido (3,4-d) pyridazines. I. Separation and structure determination of the isomeric monochloro compounds obtained by hydrolysis of 1,4-dichloropyrido (3,4-d) pyridazine", ACTA CHIM. HUNG., 112(4), (1983), p. 487-499. *
LEE, K.C. et al., "Comparisons of the depressor, inotropic and renal effects of milrinone and CI-930 to different pure vasodilators and diuretics in conscious instrumented dogs", DRUGS EXP. CLIN. RES., 17(7), (1991), p. 323-336. *

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1121220C (zh) * 1996-08-20 2003-09-17 卫材株式会社 稠合哒嗪系化合物的勃起机能不全症治疗剂
AU722710B2 (en) * 1996-08-20 2000-08-10 Eisai Co. Ltd. Remedies for erectile dysfunction containing fused pyridazine compounds
US6288064B1 (en) 1996-08-20 2001-09-11 Eisai Co., Ltd. Remedy for erection failure comprising fused pyridazine compound
EP0920868A4 (en) * 1996-08-20 2004-05-26 Eisai Co Ltd A CONDENSED PYRIDAZINE COMPOUND HEALING AGENT FOR ERECTIONAL DISEASES
US6699870B2 (en) 1998-02-19 2004-03-02 Eisai Co., Ltd. Phthalazine compounds and therapeutic agents for erectile dysfunction
WO1999042452A1 (fr) 1998-02-19 1999-08-26 Eisai Co., Ltd. Derives de phtalazine et remedes contre la dyserection
US6498159B1 (en) 1998-02-19 2002-12-24 Eisai Co., Ltd. Phthalazine derivatives and remedies for erectile dysfunction
US6576644B2 (en) 2000-09-06 2003-06-10 Bristol-Myers Squibb Co. Quinoline inhibitors of cGMP phosphodiesterase
US6835737B2 (en) 2000-09-06 2004-12-28 Bristol-Myers Squibb Company Quinoline inhibitors of cGMP phosphodiesterase
US7173042B2 (en) 2000-09-06 2007-02-06 Bristol-Myers Squibb Company Quinoline inhibitors of cGMP phosphodiesterase
US7378430B2 (en) 2000-09-06 2008-05-27 Bristol-Myers Squibb Company Quinoline inhibitors of cGMP phosphodiesterase
US7384958B2 (en) 2000-09-06 2008-06-10 Bristol-Myers Squibb Company Quinoline inhibitors of cGMP phosphodiesterase
US11618751B1 (en) 2022-03-25 2023-04-04 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives

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DE69533057D1 (de) 2004-06-24
NO309378B1 (no) 2001-01-22
NZ290952A (en) 1998-05-27
CN1135210A (zh) 1996-11-06
ATE267174T1 (de) 2004-06-15
FI961510A0 (fi) 1996-04-03
EP0722936A1 (en) 1996-07-24
NO961397L (no) 1996-06-06
HU9600933D0 (en) 1996-07-29
NO961397D0 (no) 1996-04-09
CA2173493A1 (en) 1996-02-22
US5849741A (en) 1998-12-15
AU705229B2 (en) 1999-05-20
HU219864B (hu) 2001-08-28
CN1151136C (zh) 2004-05-26
EP0722936B1 (en) 2004-05-19
HUT76067A (en) 1997-06-30
FI961510A (fi) 1996-05-29
ES2224130T3 (es) 2005-03-01
DE69533057T2 (de) 2005-06-16
FI111841B (fi) 2003-09-30
MX9601310A (es) 1998-11-30
KR100189865B1 (ko) 1999-06-01
AU3191995A (en) 1996-03-07
US6218392B1 (en) 2001-04-17
KR960704854A (ko) 1996-10-09
CA2173493C (en) 2008-03-25
EP0722936A4 (en) 1996-12-11

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