GB1417029A - Quinazoline-derived amines - Google Patents

Quinazoline-derived amines

Info

Publication number
GB1417029A
GB1417029A GB1101873A GB1101873A GB1417029A GB 1417029 A GB1417029 A GB 1417029A GB 1101873 A GB1101873 A GB 1101873A GB 1101873 A GB1101873 A GB 1101873A GB 1417029 A GB1417029 A GB 1417029A
Authority
GB
United Kingdom
Prior art keywords
alkyl
alkoxy
meo
halogen
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1101873A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Priority to GB1101873A priority Critical patent/GB1417029A/en
Priority to IE40074A priority patent/IE39546B1/en
Priority to BE141633A priority patent/BE811856A/en
Priority to LU69561A priority patent/LU69561A1/xx
Priority to DK120174A priority patent/DK132892C/en
Priority to FR7407621A priority patent/FR2220265B1/fr
Priority to DE19742410938 priority patent/DE2410938A1/en
Priority to JP2578274A priority patent/JPS5029582A/ja
Priority to NL7403075A priority patent/NL7403075A/xx
Priority to US05/464,673 priority patent/US3971783A/en
Publication of GB1417029A publication Critical patent/GB1417029A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1417029 Quinazoline - derived amines PFIZER Ltd 5 March 1974 [7 March 1973] 11018/73 Heading C2C The invention comprises compounds of formula and their pharmaceutically acceptable acid addition salts, wherein n is 1-3; R<SP>1</SP> is halogen, OH, PhCH 2 O, NH 2 or C 1-6 alkyl or alkoxy, provided that (R<SP>1</SP>) n contains at least one alkoxy group; R<SP>2</SP> is H, halogen or C 1-6 alkyl (optionally HO- or C 1-6 -alkoxy-substituted); R<SP>3</SP> is H, C 1-6 alkyl, PhCH 2 or Ph (optionally substituted by halogen or C 1-6 alkyl or alkoxy); R<SP>4</SP> is a C- attached N-containing aromatic heterocyclic group; and "alk" is C 1-4 alkylene. In examples, these compounds are prepared by reacting the appropriate 4-chloroquinazoline with R<SP>3</SP>NH-alk-R<SP>4</SP>, or by converting functional groups, by known procedures, in similarly prepared intermediates, in particular those of the above formula where the 4-substituent is N- methyl - 2 - (2 - pyridyl)ethyl and (i) R<SP>2</SP>= AcOCH 2 , (R<SP>1</SP>) n =6,7-(MeO) 2 , (ii) R<SP>2</SP>=H, (R<SP>1</SP>) n = 7-MeO-6-NO 2 , and (iii) R<SP>3</SP>=H, (R<SP>1</SP>) n = 6-EtOCO 2 -7-MeO. Therapeutic compositions having cardiac stimulant activity comprise compounds of the above formula, and may be administered orally or parenterally.
GB1101873A 1973-03-07 1973-03-07 Quinazoline-derived amines Expired GB1417029A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
GB1101873A GB1417029A (en) 1973-03-07 1973-03-07 Quinazoline-derived amines
IE40074A IE39546B1 (en) 1973-03-07 1974-02-27 Quinazoline-derived amines
BE141633A BE811856A (en) 1973-03-07 1974-03-04 NEW QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
LU69561A LU69561A1 (en) 1973-03-07 1974-03-05
DK120174A DK132892C (en) 1973-03-07 1974-03-06 ANALOGICAL PROCEDURE FOR THE PREPARATION OF 4-AMINOQUINAZOLINES
FR7407621A FR2220265B1 (en) 1973-03-07 1974-03-06
DE19742410938 DE2410938A1 (en) 1973-03-07 1974-03-07 CHINAZOLINE DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THESE
JP2578274A JPS5029582A (en) 1973-03-07 1974-03-07
NL7403075A NL7403075A (en) 1973-03-07 1974-03-07
US05/464,673 US3971783A (en) 1973-03-07 1974-04-26 4-Aminoquinazoline derivatives as cardiac stimulants

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1101873A GB1417029A (en) 1973-03-07 1973-03-07 Quinazoline-derived amines

Publications (1)

Publication Number Publication Date
GB1417029A true GB1417029A (en) 1975-12-10

Family

ID=9978541

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1101873A Expired GB1417029A (en) 1973-03-07 1973-03-07 Quinazoline-derived amines

Country Status (9)

Country Link
JP (1) JPS5029582A (en)
BE (1) BE811856A (en)
DE (1) DE2410938A1 (en)
DK (1) DK132892C (en)
FR (1) FR2220265B1 (en)
GB (1) GB1417029A (en)
IE (1) IE39546B1 (en)
LU (1) LU69561A1 (en)
NL (1) NL7403075A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2014662A1 (en) * 2007-07-12 2009-01-14 Bayer Schering Pharma Aktiengesellschaft Indolyl alkyl thieno-pyrimidyl amines as modulators of EP2 receptors

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1460389A (en) * 1974-07-25 1977-01-06 Pfizer Ltd 4-substituted quinazoline cardiac stimulants
JPS52126939A (en) * 1976-04-19 1977-10-25 Stanley Electric Co Ltd Method of filtering regenerative drain water treating device
IT1229237B (en) * 1989-05-08 1991-07-26 Prodotti Formenti SALTS OF (2- (PYRIDYL) ETHYL) METHYLAMINE
CA2148260A1 (en) * 1993-09-10 1995-03-16 Yasutaka Takase Quinazoline cpompounds
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
IL112248A0 (en) 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
ES2224130T3 (en) * 1994-08-09 2005-03-01 Eisai Co., Ltd. CONDENSED PIRIDAZINE COMPOUND.
ATE274510T1 (en) 1998-06-19 2004-09-15 Chiron Corp GLYCOGEN SYNTHASE KINASE 3 INHIBITORS
PL373429A1 (en) * 2002-07-17 2005-08-22 Lek Pharmaceuticals D.D. Novel derivatives of pyridylethanol (phenylethyl) amines as inhibitors of cholesterol biosynthesis, processes for their preparation, and pharmaceutical compositions containing them
CN101277939A (en) * 2005-09-09 2008-10-01 布里斯托尔-迈尔斯斯奎布公司 Acyclic ikur inhibitors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2014662A1 (en) * 2007-07-12 2009-01-14 Bayer Schering Pharma Aktiengesellschaft Indolyl alkyl thieno-pyrimidyl amines as modulators of EP2 receptors
WO2009007421A1 (en) * 2007-07-12 2009-01-15 Bayer Schering Pharma Aktiengesellschaft Indolylalkylthienopyrimidylamines as modulators of the ep2 receptor

Also Published As

Publication number Publication date
FR2220265B1 (en) 1977-11-10
IE39546L (en) 1974-09-07
DK132892B (en) 1976-02-23
IE39546B1 (en) 1978-11-08
JPS5029582A (en) 1975-03-25
NL7403075A (en) 1974-09-10
DK132892C (en) 1976-07-19
FR2220265A1 (en) 1974-10-04
BE811856A (en) 1974-09-04
DE2410938A1 (en) 1974-09-19
LU69561A1 (en) 1976-02-04

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee