IE39546L - Quinazoline derivatives - Google Patents

Quinazoline derivatives

Info

Publication number
IE39546L
IE39546L IE40074A IE40074A IE39546L IE 39546 L IE39546 L IE 39546L IE 40074 A IE40074 A IE 40074A IE 40074 A IE40074 A IE 40074A IE 39546 L IE39546 L IE 39546L
Authority
IE
Ireland
Prior art keywords
alkyl
alkoxy
meo
halogen
compounds
Prior art date
Application number
IE40074A
Other versions
IE39546B1 (en
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of IE39546L publication Critical patent/IE39546L/en
Publication of IE39546B1 publication Critical patent/IE39546B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1417029 Quinazoline - derived amines PFIZER Ltd 5 March 1974 [7 March 1973] 11018/73 Heading C2C The invention comprises compounds of formula and their pharmaceutically acceptable acid addition salts, wherein n is 1-3; R<SP>1</SP> is halogen, OH, PhCH 2 O, NH 2 or C 1-6 alkyl or alkoxy, provided that (R<SP>1</SP>) n contains at least one alkoxy group; R<SP>2</SP> is H, halogen or C 1-6 alkyl (optionally HO- or C 1-6 -alkoxy-substituted); R<SP>3</SP> is H, C 1-6 alkyl, PhCH 2 or Ph (optionally substituted by halogen or C 1-6 alkyl or alkoxy); R<SP>4</SP> is a C- attached N-containing aromatic heterocyclic group; and "alk" is C 1-4 alkylene. In examples, these compounds are prepared by reacting the appropriate 4-chloroquinazoline with R<SP>3</SP>NH-alk-R<SP>4</SP>, or by converting functional groups, by known procedures, in similarly prepared intermediates, in particular those of the above formula where the 4-substituent is N- methyl - 2 - (2 - pyridyl)ethyl and (i) R<SP>2</SP>= AcOCH 2 , (R<SP>1</SP>) n =6,7-(MeO) 2 , (ii) R<SP>2</SP>=H, (R<SP>1</SP>) n = 7-MeO-6-NO 2 , and (iii) R<SP>3</SP>=H, (R<SP>1</SP>) n = 6-EtOCO 2 -7-MeO. Therapeutic compositions having cardiac stimulant activity comprise compounds of the above formula, and may be administered orally or parenterally. [GB1417029A]
IE40074A 1973-03-07 1974-02-27 Quinazoline-derived amines IE39546B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1101873A GB1417029A (en) 1973-03-07 1973-03-07 Quinazoline-derived amines

Publications (2)

Publication Number Publication Date
IE39546L true IE39546L (en) 1974-09-07
IE39546B1 IE39546B1 (en) 1978-11-08

Family

ID=9978541

Family Applications (1)

Application Number Title Priority Date Filing Date
IE40074A IE39546B1 (en) 1973-03-07 1974-02-27 Quinazoline-derived amines

Country Status (9)

Country Link
JP (1) JPS5029582A (en)
BE (1) BE811856A (en)
DE (1) DE2410938A1 (en)
DK (1) DK132892C (en)
FR (1) FR2220265B1 (en)
GB (1) GB1417029A (en)
IE (1) IE39546B1 (en)
LU (1) LU69561A1 (en)
NL (1) NL7403075A (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1460389A (en) * 1974-07-25 1977-01-06 Pfizer Ltd 4-substituted quinazoline cardiac stimulants
JPS52126939A (en) * 1976-04-19 1977-10-25 Stanley Electric Co Ltd Method of filtering regenerative drain water treating device
IT1229237B (en) * 1989-05-08 1991-07-26 Prodotti Formenti SALTS OF (2- (PYRIDYL) ETHYL) METHYLAMINE
US5614627A (en) * 1993-09-10 1997-03-25 Eisai Co., Ltd. Quinazoline compounds
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
IL112248A0 (en) 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
HU219864B (en) 1994-08-09 2001-08-28 Eisai Co., Ltd. Cgmp-pde inhibitory fused pyridazine derivatives and use thereof
JP4533534B2 (en) 1998-06-19 2010-09-01 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド Inhibitor of glycogen synthase kinase 3
EP1546105A1 (en) * 2002-07-17 2005-06-29 Lek Pharmaceutical and Chemical Co. D.D. Novel derivatives of pyridylethanol (phenylethyl) amines as inhibitors of cholesterol biosynthesis, processes for their preparation, and pharmaceutical compositions containing them
WO2007030582A2 (en) * 2005-09-09 2007-03-15 Bristol-Myers Squibb Company Acyclic ikur inhibitors
EP2014662A1 (en) * 2007-07-12 2009-01-14 Bayer Schering Pharma Aktiengesellschaft Indolyl alkyl thieno-pyrimidyl amines as modulators of EP2 receptors

Also Published As

Publication number Publication date
DE2410938A1 (en) 1974-09-19
IE39546B1 (en) 1978-11-08
DK132892C (en) 1976-07-19
GB1417029A (en) 1975-12-10
JPS5029582A (en) 1975-03-25
FR2220265A1 (en) 1974-10-04
NL7403075A (en) 1974-09-10
FR2220265B1 (en) 1977-11-10
LU69561A1 (en) 1976-02-04
BE811856A (en) 1974-09-04
DK132892B (en) 1976-02-23

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