IE40052L - Piperidinoalkylindoles - Google Patents

Piperidinoalkylindoles

Info

Publication number
IE40052L
IE40052L IE741956A IE195674A IE40052L IE 40052 L IE40052 L IE 40052L IE 741956 A IE741956 A IE 741956A IE 195674 A IE195674 A IE 195674A IE 40052 L IE40052 L IE 40052L
Authority
IE
Ireland
Prior art keywords
compounds
formula
hypotensive
activity
gb1425354a
Prior art date
Application number
IE741956A
Other versions
IE40052B1 (en
Original Assignee
Wyeth John & Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth John & Brother Ltd filed Critical Wyeth John & Brother Ltd
Publication of IE40052L publication Critical patent/IE40052L/en
Publication of IE40052B1 publication Critical patent/IE40052B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

The compounds of the formula I <IMAGE> in which the substituents R<1>, R<2>, R<3>, R<4> and X are defined in Claim 1, are prepared by reaction of an appropriately substituted indole derivative with an isocyanate or isothiocyanate containing the substituent R<4>. The compounds of the formula I can be converted into their corresponding acid addition salts or quaternary ammonium salts. If R<4> denotes acyl, the possibility also exists of hydrolysing compounds of the formula I to the corresponding amino compound. The said compounds have a hypotensive and antihypertensive activity and can be used as medicaments for the treatment of hypertension or alternatively as intermediates for the preparation of compounds having hypotensive activity. [GB1425354A]
IE1956/74A 1973-10-10 1974-09-23 Indole derivatives IE40052B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB4720873 1973-10-10
GB353174*[A GB1425354A (en) 1973-10-10 1974-01-25 Indole derivatives
GB727774 1974-02-18

Publications (2)

Publication Number Publication Date
IE40052L true IE40052L (en) 1975-04-10
IE40052B1 IE40052B1 (en) 1979-02-28

Family

ID=27254287

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1956/74A IE40052B1 (en) 1973-10-10 1974-09-23 Indole derivatives

Country Status (10)

Country Link
JP (1) JPS6039678B2 (en)
CH (4) CH611615A5 (en)
DE (1) DE2447947A1 (en)
FR (1) FR2247239B1 (en)
GB (1) GB1425354A (en)
HK (1) HK36179A (en)
IE (1) IE40052B1 (en)
KE (1) KE2950A (en)
MY (1) MY7900210A (en)
NL (1) NL179731C (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4147786A (en) 1976-02-02 1979-04-03 Ciba-Geigy Corporation 1-Indolylalkyl-3-or 4-trimethyleneurido-piperidines
GB1542137A (en) * 1976-03-12 1979-03-14 Wyeth John & Brother Ltd Process for preparing 3(piperidinoalkyl)indoles
JPS56158Y2 (en) * 1976-06-28 1981-01-06
GB1586817A (en) * 1977-12-01 1981-03-25 Wyeth John & Brother Ltd Indole derivatives
US4242347A (en) 1979-06-18 1980-12-30 Ciba-Geigy Corporation Hypotensive indolylalkylpiperidyl guanidines and isoureas
JPS62157297U (en) * 1986-03-27 1987-10-06
DK733788A (en) * 1988-01-14 1989-07-15 Fujisawa Pharmaceutical Co INDOLYL PIPERIDE INGREDIENTS AND PROCEDURES FOR PREPARING THEREOF
SE9902987D0 (en) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
FR2802206B1 (en) * 1999-12-14 2005-04-22 Sod Conseils Rech Applic 4-AMINOPIPERIDINE DERIVATIVES AND THEIR USE AS MEDICINAL PRODUCTS
GB0011838D0 (en) * 2000-05-17 2000-07-05 Astrazeneca Ab Chemical compounds
GB0104050D0 (en) 2001-02-19 2001-04-04 Astrazeneca Ab Chemical compounds
GB0107228D0 (en) 2001-03-22 2001-05-16 Astrazeneca Ab Chemical compounds
SE0103818D0 (en) 2001-11-15 2001-11-15 Astrazeneca Ab Chemical compounds
SE0301369D0 (en) 2003-05-09 2003-05-09 Astrazeneca Ab Chemical compounds

Also Published As

Publication number Publication date
FR2247239A1 (en) 1975-05-09
JPS6039678B2 (en) 1985-09-06
NL179731C (en) 1986-11-03
CH610323A5 (en) 1979-04-12
FR2247239B1 (en) 1978-07-21
CH612431A5 (en) 1979-07-31
GB1425354A (en) 1976-02-18
KE2950A (en) 1979-04-27
CH613449A5 (en) 1979-09-28
NL179731B (en) 1986-06-02
HK36179A (en) 1979-06-15
JPS5076076A (en) 1975-06-21
IE40052B1 (en) 1979-02-28
DE2447947A1 (en) 1975-04-17
CH611615A5 (en) 1979-06-15
NL7413358A (en) 1975-04-14
MY7900210A (en) 1979-12-31

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