IE42962L - Phthalimidine and benzisothiazoline derivatives. - Google Patents
Phthalimidine and benzisothiazoline derivatives.Info
- Publication number
- IE42962L IE42962L IE760439A IE43976A IE42962L IE 42962 L IE42962 L IE 42962L IE 760439 A IE760439 A IE 760439A IE 43976 A IE43976 A IE 43976A IE 42962 L IE42962 L IE 42962L
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- phthalimidine
- benzisothiazoline
- derivatives
- accompanying
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Novel substituted arylalkylamines of the accompanying formula I, in which the symbols R1 to R7, X and n have the meaning given in Patent Claim 1, are prepared by reacting a compound of the accompanying formula II, in which Z denotes a removable radical, with an appropriately substituted phenylethylamine. The compounds of the formula I and their acid addition salts are distinguished by useful pharmacological properties. In addition to a mild hypotensive action, they particularly have a selective heart rate-lowering action. <IMAGE>
[GB1503625A]
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2509797A DE2509797C2 (en) | 1975-03-06 | 1975-03-06 | Phthalimidines, their physiologically acceptable acid addition salts, processes for their preparation and pharmaceuticals containing these compounds |
| DE19752558274 DE2558274A1 (en) | 1975-12-23 | 1975-12-23 | N-substd. phthalimidines and benzo isothiazolines - for coronary insufficiency and angina pectoris |
| DE19752558273 DE2558273A1 (en) | 1975-12-23 | 1975-12-23 | NEW PROCESSES FOR THE PRODUCTION OF ARYLALKYLAMINES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE42962L true IE42962L (en) | 1976-09-06 |
| IE42962B1 IE42962B1 (en) | 1980-11-19 |
Family
ID=27186298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE439/76A IE42962B1 (en) | 1975-03-06 | 1976-03-03 | Phthalimidine and benzisothiazoline derivatives |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS51113866A (en) |
| AU (1) | AU498958B2 (en) |
| CA (1) | CA1073915A (en) |
| CH (1) | CH621340A5 (en) |
| DD (1) | DD123741A5 (en) |
| DK (1) | DK138792C (en) |
| ES (1) | ES445812A1 (en) |
| FI (1) | FI61694C (en) |
| FR (1) | FR2302733A1 (en) |
| GB (1) | GB1503625A (en) |
| GR (1) | GR60053B (en) |
| HK (1) | HK46881A (en) |
| IE (1) | IE42962B1 (en) |
| IL (1) | IL49150A (en) |
| LU (1) | LU74479A1 (en) |
| MX (1) | MX3393E (en) |
| NL (1) | NL7601796A (en) |
| NO (1) | NO144212C (en) |
| PT (1) | PT64873B (en) |
| SE (1) | SE418398B (en) |
| SU (1) | SU620209A3 (en) |
| YU (3) | YU40642B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3242477A1 (en) * | 1982-11-18 | 1984-05-24 | Basf Ag, 6700 Ludwigshafen | HETEROCYCLICALLY SUBSTITUTED NITRILES, THEIR PRODUCTION AND USE AS MEDICINAL PRODUCTS |
| GB8609331D0 (en) * | 1986-04-16 | 1986-05-21 | Pfizer Ltd | Anti-arrythmia agents |
| US5567718A (en) * | 1994-08-11 | 1996-10-22 | Hoechst Marion Roussel Inc. | 2,3-dihydro-1h-isoindole derivatives and their use as serotonin reuptake inhibitors |
| EP1289965B1 (en) | 2000-05-25 | 2005-10-26 | F. Hoffmann-La Roche Ag | Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists |
-
1976
- 1976-02-18 DD DD191310A patent/DD123741A5/xx unknown
- 1976-02-23 NL NL7601796A patent/NL7601796A/en unknown
- 1976-02-24 GR GR50141A patent/GR60053B/en unknown
- 1976-02-24 FI FI760465A patent/FI61694C/en not_active IP Right Cessation
- 1976-02-25 SU SU762325959A patent/SU620209A3/en active
- 1976-02-27 SE SE7602856A patent/SE418398B/en not_active IP Right Cessation
- 1976-03-03 IE IE439/76A patent/IE42962B1/en unknown
- 1976-03-03 CH CH266676A patent/CH621340A5/en not_active IP Right Cessation
- 1976-03-04 JP JP51023699A patent/JPS51113866A/en active Granted
- 1976-03-04 YU YU550/76A patent/YU40642B/en unknown
- 1976-03-04 IL IL49150A patent/IL49150A/en unknown
- 1976-03-04 DK DK92876A patent/DK138792C/en active
- 1976-03-04 LU LU74479A patent/LU74479A1/xx unknown
- 1976-03-05 CA CA247,229A patent/CA1073915A/en not_active Expired
- 1976-03-05 MX MX000041U patent/MX3393E/en unknown
- 1976-03-05 GB GB8961/76A patent/GB1503625A/en not_active Expired
- 1976-03-05 PT PT64873A patent/PT64873B/en unknown
- 1976-03-05 ES ES445812A patent/ES445812A1/en not_active Expired
- 1976-03-05 NO NO760766A patent/NO144212C/en unknown
- 1976-03-05 FR FR7606435A patent/FR2302733A1/en active Granted
-
1978
- 1978-03-05 AU AU11729/76A patent/AU498958B2/en not_active Expired
-
1981
- 1981-09-17 HK HK468/81A patent/HK46881A/en unknown
-
1982
- 1982-05-07 YU YU00980/82A patent/YU98082A/en unknown
- 1982-05-07 YU YU00981/82A patent/YU98182A/en unknown
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