ES461758A1 - Process for the preparation of thiochroman derivatives - Google Patents

Process for the preparation of thiochroman derivatives

Info

Publication number
ES461758A1
ES461758A1 ES461758A ES461758A ES461758A1 ES 461758 A1 ES461758 A1 ES 461758A1 ES 461758 A ES461758 A ES 461758A ES 461758 A ES461758 A ES 461758A ES 461758 A1 ES461758 A1 ES 461758A1
Authority
ES
Spain
Prior art keywords
reaction
compounds
preparation
same compounds
amine r2nh2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES461758A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Publication of ES461758A1 publication Critical patent/ES461758A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

A side chain -OCH2CHOHCH2NHR2 is fixed to a hydroxythiochroman of formula: < IMAGE > by a 2-stage synthesis, a) reaction with a glycerol halohydrin in basic medium and b) reaction of the 2,3-dihydroxypropoxythiochroman thus formed with an amine R2NH2 in the presence of an aminotriphenylphosphonium halide. The compounds (I) thus obtained and their salts are known as beta -blocking agents and used, especially, in the treatment of disorders of the cardiac rhythm. Compared with the prior process starting from the same compounds (II) and ending in the same compounds (I), the new process requires shorter reaction times and a reduced quantity of the amine R2NH2, which makes possible a selective amination of the primary alcohol functional group.
ES461758A 1976-08-23 1977-08-19 Process for the preparation of thiochroman derivatives Expired ES461758A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB35029/76A GB1561153A (en) 1976-08-23 1976-08-23 Process for the preparation of thiochroman derivatives

Publications (1)

Publication Number Publication Date
ES461758A1 true ES461758A1 (en) 1978-05-01

Family

ID=10372964

Family Applications (1)

Application Number Title Priority Date Filing Date
ES461758A Expired ES461758A1 (en) 1976-08-23 1977-08-19 Process for the preparation of thiochroman derivatives

Country Status (14)

Country Link
JP (1) JPS5325571A (en)
AR (1) AR215142A1 (en)
CA (1) CA1103683A (en)
CH (1) CH623818A5 (en)
ES (1) ES461758A1 (en)
GB (1) GB1561153A (en)
HK (1) HK8684A (en)
HU (1) HU178104B (en)
MX (1) MX5095E (en)
NL (1) NL190521C (en)
OA (1) OA05744A (en)
PH (1) PH16402A (en)
SU (1) SU880251A3 (en)
YU (1) YU40169B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2530954B1 (en) * 1982-07-29 1985-09-13 Adir PHARMACEUTICAL COMPOSITION BASED ON 8- (3-TERTBUTYLAMINO, 2-HYDROXY-PROPOXY) -THIACHROMANNE
JPS5947574A (en) * 1982-09-08 1984-03-17 Tlv Co Ltd Multidirection ball valve
FR2588260B1 (en) * 1985-10-04 1987-11-20 Adir NOVEL THIOCHROMAN DERIVATIVE, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
JPS63280785A (en) * 1987-05-14 1988-11-17 Mitsui Toatsu Chem Inc Structural adhesive

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1308191A (en) * 1970-04-06 1973-02-21 Science Union & Cie Thiochroman derivatives and a process for preparing them

Also Published As

Publication number Publication date
GB1561153A (en) 1980-02-13
JPS623150B2 (en) 1987-01-23
MX5095E (en) 1983-03-16
NL190521B (en) 1993-11-01
HK8684A (en) 1984-02-10
CA1103683A (en) 1981-06-23
YU40169B (en) 1985-08-31
SU880251A3 (en) 1981-11-07
PH16402A (en) 1983-09-22
YU176777A (en) 1982-06-30
NL7709229A (en) 1978-02-27
OA05744A (en) 1981-05-31
HU178104B (en) 1982-03-28
NL190521C (en) 1994-04-05
JPS5325571A (en) 1978-03-09
CH623818A5 (en) 1981-06-30
AR215142A1 (en) 1979-09-14

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990405