SE7611953L - PROCEDURE FOR PREPARING AROYL-PHENYL-NAFTALENDER DERIVATIVES USABLE AS ANTIFERTILITY AND ANTITUMOR MEANS - Google Patents
PROCEDURE FOR PREPARING AROYL-PHENYL-NAFTALENDER DERIVATIVES USABLE AS ANTIFERTILITY AND ANTITUMOR MEANSInfo
- Publication number
- SE7611953L SE7611953L SE7611953A SE7611953A SE7611953L SE 7611953 L SE7611953 L SE 7611953L SE 7611953 A SE7611953 A SE 7611953A SE 7611953 A SE7611953 A SE 7611953A SE 7611953 L SE7611953 L SE 7611953L
- Authority
- SE
- Sweden
- Prior art keywords
- formula
- compounds
- naftalender
- antifertility
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
- C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/265—Citric acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Aroylphenylnaphthalenes of the formula I <IMAGE> in which X is -CH2-CH2- or -CH=CH-, R is hydrogen or C1-C5-alkoxy, R1 is hydrogen or C1-C5-alkoxy, and the substituents R2 and R3 form, together with the nitrogen atom to which they are bonded, a pyrrolidino group, and the pharmaceutically acceptable non-toxic acid addition salts thereof are obtained by reacting a naphthalene derivative with a chloro-2-aminoethane, and converting resulting compounds of the formula I where appropriate into the pharmaceutically acceptable non-toxic acid addition salts. The compounds of the formula (I) which can be prepared according to the invention are, as a rule, valuable medicines. They are normally distinguished particularly by a fertility-inhibiting action and are therefore suitable in particular as orally active fertility-inhibiting agents in birds and mammals. The compounds of the formula (I) which can be prepared according to the invention may therefore be suitable for controlling the animal population and as contraceptives for life forms. These compounds can furthermore also be used, for example, to control animal pests.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62599175A | 1975-10-28 | 1975-10-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7611953L true SE7611953L (en) | 1977-04-29 |
| SE428689B SE428689B (en) | 1983-07-18 |
Family
ID=24508491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7611953A SE428689B (en) | 1975-10-28 | 1976-10-27 | PROCEDURE FOR PREPARING AROYL-PHENYL AGREEMENT COMPOUNDS |
Country Status (30)
| Country | Link |
|---|---|
| JP (1) | JPS6045191B2 (en) |
| AR (1) | AR214622A1 (en) |
| AT (1) | AT346321B (en) |
| AU (1) | AU509372B2 (en) |
| BE (1) | BE847716A (en) |
| BG (1) | BG27555A3 (en) |
| CA (1) | CA1078834A (en) |
| CH (2) | CH624398A5 (en) |
| CS (1) | CS235057B2 (en) |
| DD (1) | DD127460A5 (en) |
| DE (1) | DE2646213A1 (en) |
| DK (1) | DK484776A (en) |
| ES (1) | ES452735A1 (en) |
| FR (1) | FR2329264A1 (en) |
| GB (1) | GB1561687A (en) |
| GR (1) | GR61816B (en) |
| HU (1) | HU175227B (en) |
| IE (1) | IE43641B1 (en) |
| IL (1) | IL50772A (en) |
| MX (1) | MX4291E (en) |
| NL (1) | NL187164C (en) |
| NZ (1) | NZ182421A (en) |
| PH (1) | PH14538A (en) |
| PL (2) | PL111987B1 (en) |
| PT (1) | PT65752B (en) |
| RO (1) | RO70755A (en) |
| SE (1) | SE428689B (en) |
| SU (2) | SU791220A3 (en) |
| YU (1) | YU262276A (en) |
| ZA (1) | ZA766439B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179558A (en) * | 1978-01-30 | 1979-12-18 | E. R. Squibb & Sons, Inc. | Naphthalenone derivatives and analogs |
| DE3121175A1 (en) * | 1981-05-27 | 1982-12-16 | Klinge Pharma GmbH, 8000 München | ERYTHRO-1,2,3-TRIPHENYL-1-PENTANONE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS |
| JPH0717589B2 (en) * | 1990-01-22 | 1995-03-01 | ファイザー製薬株式会社 | Novel 1,3-dicarbonyl compound and composition thereof |
| US6391892B1 (en) * | 1995-03-10 | 2002-05-21 | Eli Lilly And Company | Naphthyl pharmaceutical compounds |
-
1976
- 1976-10-13 DE DE19762646213 patent/DE2646213A1/en active Granted
- 1976-10-20 MX MX764988U patent/MX4291E/en unknown
- 1976-10-21 NZ NZ182421A patent/NZ182421A/en unknown
- 1976-10-21 CA CA263,896A patent/CA1078834A/en not_active Expired
- 1976-10-22 GB GB43884/76A patent/GB1561687A/en not_active Expired
- 1976-10-22 PH PH19030A patent/PH14538A/en unknown
- 1976-10-25 GR GR52004A patent/GR61816B/en unknown
- 1976-10-25 PT PT65752A patent/PT65752B/en unknown
- 1976-10-26 AU AU19004/76A patent/AU509372B2/en not_active Expired
- 1976-10-26 PL PL1976211453A patent/PL111987B1/en unknown
- 1976-10-26 ES ES452735A patent/ES452735A1/en not_active Expired
- 1976-10-26 PL PL1976193264A patent/PL104551B1/en unknown
- 1976-10-26 SU SU762414461A patent/SU791220A3/en active
- 1976-10-26 RO RO7688227A patent/RO70755A/en unknown
- 1976-10-26 JP JP51129305A patent/JPS6045191B2/en not_active Expired
- 1976-10-27 SE SE7611953A patent/SE428689B/en not_active IP Right Cessation
- 1976-10-27 ZA ZA00766439A patent/ZA766439B/en unknown
- 1976-10-27 DK DK484776A patent/DK484776A/en not_active Application Discontinuation
- 1976-10-27 IL IL50772A patent/IL50772A/en unknown
- 1976-10-27 IE IE2371/76A patent/IE43641B1/en unknown
- 1976-10-27 CH CH1355476A patent/CH624398A5/en not_active IP Right Cessation
- 1976-10-27 YU YU02622/76A patent/YU262276A/en unknown
- 1976-10-27 HU HU76EI716A patent/HU175227B/en unknown
- 1976-10-28 AT AT800576A patent/AT346321B/en not_active IP Right Cessation
- 1976-10-28 DD DD195507A patent/DD127460A5/xx unknown
- 1976-10-28 BG BG7634552A patent/BG27555A3/en unknown
- 1976-10-28 CS CS766971A patent/CS235057B2/en unknown
- 1976-10-28 NL NLAANVRAGE7611974,A patent/NL187164C/en not_active IP Right Cessation
- 1976-10-28 FR FR7632511A patent/FR2329264A1/en active Granted
- 1976-10-28 AR AR265274A patent/AR214622A1/en active
- 1976-10-28 BE BE1007722A patent/BE847716A/en not_active IP Right Cessation
-
1978
- 1978-07-25 SU SU782641053A patent/SU818476A3/en active
-
1980
- 1980-08-28 CH CH648780A patent/CH624376A5/en not_active IP Right Cessation
Also Published As
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