WO1996001324A3 - Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique - Google Patents

Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique Download PDF

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Publication number
WO1996001324A3
WO1996001324A3 PCT/FR1995/000894 FR9500894W WO9601324A3 WO 1996001324 A3 WO1996001324 A3 WO 1996001324A3 FR 9500894 W FR9500894 W FR 9500894W WO 9601324 A3 WO9601324 A3 WO 9601324A3
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WO
WIPO (PCT)
Prior art keywords
internal ribosome
ribosome entry
entry site
vector containing
containing same
Prior art date
Application number
PCT/FR1995/000894
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English (en)
Other versions
WO1996001324A2 (fr
Inventor
Clarisse Berlioz
Sandrine Jacquemoud
Christophe Torrent
Jean-Luc Darlix
Original Assignee
Inst Nat Sante Rech Med
Clarisse Berlioz
Sandrine Jacquemoud
Christophe Torrent
Darlix Jean Luc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med, Clarisse Berlioz, Sandrine Jacquemoud, Christophe Torrent, Darlix Jean Luc filed Critical Inst Nat Sante Rech Med
Priority to US08/600,999 priority Critical patent/US5925565A/en
Priority to EP95925007A priority patent/EP0769062A2/fr
Priority to JP8503707A priority patent/JPH10503644A/ja
Priority to AU29295/95A priority patent/AU707874B2/en
Publication of WO1996001324A2 publication Critical patent/WO1996001324A2/fr
Publication of WO1996001324A3 publication Critical patent/WO1996001324A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13051—Methods of production or purification of viral material
    • C12N2740/13052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/90—Vectors containing a transposable element
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/802—Virus-based particle
    • Y10S977/803—Containing biological material in its interior
    • Y10S977/804—Containing nucleic acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/92—Detection of biochemical

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention a pour objet un nouveau site interne d'entrée des ribosomes et une nouvelle région d'encapsidation d'un rétrotransposon et notamment des VL30 murins. Elle concerne également un vecteur et une cellule eucaryote les contenant ainsi que leur usage thérapeutique ou prophylactique.
PCT/FR1995/000894 1994-07-05 1995-07-05 Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique WO1996001324A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US08/600,999 US5925565A (en) 1994-07-05 1995-07-05 Internal ribosome entry site, vector containing it and therapeutic use
EP95925007A EP0769062A2 (fr) 1994-07-05 1995-07-05 Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique
JP8503707A JPH10503644A (ja) 1994-07-05 1995-07-05 新規な内部リボソーム侵入部位、これを含むベクター、および治療への使用
AU29295/95A AU707874B2 (en) 1994-07-05 1995-07-05 New internal ribosome entry site, vector containing it and therapeutical use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9408300A FR2722208B1 (fr) 1994-07-05 1994-07-05 Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique
FR94/08300 1994-07-05

Publications (2)

Publication Number Publication Date
WO1996001324A2 WO1996001324A2 (fr) 1996-01-18
WO1996001324A3 true WO1996001324A3 (fr) 1996-02-29

Family

ID=9465025

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1995/000894 WO1996001324A2 (fr) 1994-07-05 1995-07-05 Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique

Country Status (7)

Country Link
US (1) US5925565A (fr)
EP (1) EP0769062A2 (fr)
JP (1) JPH10503644A (fr)
AU (1) AU707874B2 (fr)
CA (1) CA2194155A1 (fr)
FR (1) FR2722208B1 (fr)
WO (1) WO1996001324A2 (fr)

Families Citing this family (182)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6605712B1 (en) * 1990-12-20 2003-08-12 Arch Development Corporation Gene transcription and ionizing radiation: methods and compositions
US20030215795A1 (en) * 1991-06-28 2003-11-20 Frey Teryl K. Highly infectious rubella virus DNA constructs and methods of production
US6958237B2 (en) 1991-06-28 2005-10-25 Georgia State Univesity Research Foundation, Inc. Highly infectious rubella virus DNA constructs and methods of production
DE19514310A1 (de) * 1995-04-18 1996-10-24 Univ Ludwigs Albert Vektoren zur Transfektion von eukaryotischen Zellen, deren Verwendung und damit transfizierte Zielzellen
FR2747046B1 (fr) * 1996-04-05 1998-06-19 Univ Paris Curie Nouveaux vaccins issus de plasmovirus
FR2755975B1 (fr) * 1996-11-15 1999-05-07 Rhone Poulenc Rorer Sa Virus recombinants bicistroniques utiles pour le traitement de pathologies liees aux dyslipoproteinemies
FR2757061B1 (fr) * 1996-12-16 1999-03-26 Rhone Merieux Vaccin vivant recombinant aviaire, utilisant comme vecteur le virus de la laryngotracheite infectieuse aviaire
FR2762615B1 (fr) * 1997-04-28 1999-07-16 Inst Nat Sante Rech Med Nouveau site interne d'entree des ribosomes et vecteur le contenant
FR2766091A1 (fr) 1997-07-18 1999-01-22 Transgene Sa Composition antitumorale a base de polypeptide immunogene de localisation cellulaire modifiee
AU1591099A (en) * 1997-11-19 1999-06-07 Nature Technology, Inc. Chimeric viral packaging signal without (gag) gene sequences
US20030138808A1 (en) * 1998-02-19 2003-07-24 Simard John J.L. Expression vectors encoding epitopes of target-associated antigens
AU767880B2 (en) * 1998-03-16 2003-11-27 Introgen Therapeutics, Inc. Multigene vectors
AU1128400A (en) 1998-10-22 2000-05-08 Medical College Of Georgia Institute, Inc. Long terminal repeat, enhancer, and insulator sequences for use in recombinant vectors
US6924099B1 (en) * 1999-01-29 2005-08-02 G.D. Searle & Co. Biomarkers and assays for carcinogenesis
EP1173597A1 (fr) * 1999-04-29 2002-01-23 Aarhus University Expression de genes heterologues, a partir d'une cassette de traduction ires, dans des vecteurs retroviraux
CN100352921C (zh) 1999-05-06 2007-12-05 威克福雷大学 用于鉴定引起免疫反应的抗原的组合物和方法
DE60045350D1 (de) 1999-06-01 2011-01-20 Baylor College Medicine Zusammensetzungen und verfahren zur therapeutischen anwendung einer mit dem gen atonal assoziierten sequenz
US6861234B1 (en) 2000-04-28 2005-03-01 Mannkind Corporation Method of epitope discovery
DE60142615D1 (de) * 2000-04-28 2010-09-02 Mannkind Corp Epitop-synchronisierung in antigen präsentierenden zellen
US20030215425A1 (en) * 2001-12-07 2003-11-20 Simard John J. L. Epitope synchronization in antigen presenting cells
WO2002014492A2 (fr) * 2000-08-14 2002-02-21 Iogenetics, Llc Bovins resistant au syndrome de la vache grasse
AU2002215499A1 (en) * 2000-09-15 2002-03-26 Institut National De La Sante Et De La Recherche Medicale (Inserm) Internal ribosome entry sites (ires) of errantiviruses and uses thereof
US7575924B2 (en) 2000-11-13 2009-08-18 Research Development Foundation Methods and compositions relating to improved lentiviral vectors and their applications
US8034791B2 (en) 2001-04-06 2011-10-11 The University Of Chicago Activation of Egr-1 promoter by DNA damaging chemotherapeutics
US20040242523A1 (en) * 2003-03-06 2004-12-02 Ana-Farber Cancer Institue And The Univiersity Of Chicago Chemo-inducible cancer gene therapy
EP1390075B1 (fr) * 2001-04-06 2012-01-18 The University of Chicago Induction chimiotherapeutique de l'activite du promoteur egr-1 dans la therapie genique
EP1412493B1 (fr) 2001-08-02 2011-10-05 Institut Clayton De La Recherche Procedes et compositions relatifs a des systemes production ameliores de vecteurs lentiviraux
US7647184B2 (en) * 2001-08-27 2010-01-12 Hanall Pharmaceuticals, Co. Ltd High throughput directed evolution by rational mutagenesis
US20030129203A1 (en) * 2001-08-27 2003-07-10 Nautilus Biotech S.A. Mutant recombinant adeno-associated viruses
AU2002324909A1 (en) * 2001-09-07 2003-03-24 Baylor College Of Medicine Linear dna fragments for gene expression
IL161229A0 (en) * 2001-10-02 2004-09-27 Inst Clayton De La Rech Methods and compositions relating to restricted expression lentiviral vectors and their applications.
WO2003038112A2 (fr) 2001-10-26 2003-05-08 Baylor College Of Medicine Composition et methode permettant de modifier la masse maigre et les proprietes osseuses d'un sujet
WO2003040690A2 (fr) * 2001-11-02 2003-05-15 Rice University Systeme de recyclage permettant la manipulation de la disponibilite intracellulaire du nadh
CN1313617C (zh) * 2001-11-07 2007-05-02 曼康公司 编码靶相关抗原表位的表达载体及其设计方法
US20030157641A1 (en) * 2001-11-16 2003-08-21 Idec Pharmaceuticals Corporation Polycistronic expression of antibodies
US7241744B2 (en) 2001-12-11 2007-07-10 Baylor College Of Medicine Treating anemia in subjects by administration of plasmids encoding growth hormone releasing hormone
US20030224404A1 (en) * 2002-02-25 2003-12-04 Manuel Vega High throughput directed evolution of nucleic acids by rational mutagenesis
JP4343708B2 (ja) * 2002-04-26 2009-10-14 アンスティテュ ナシナル ドゥ ラ サントゥ エ ドゥ ラ ルシェルシェ メディカル−イ．エヌ．エス．ウ．エール．エム． 改良型キメラ糖タンパク質と、類型化されたレンチウイルス
EP1501861A4 (fr) 2002-05-06 2007-06-20 Univ Texas Ciblage de proteines pour l'apport de reactifs therapeutiques ou de diagnostic
EP2269619A1 (fr) 2002-08-12 2011-01-05 Jennerex Biotherapeutics ULC Procédés et compositions concernant des poxvirus et le cancer
US20050202438A1 (en) * 2002-09-09 2005-09-15 Rene Gantier Rational directed protein evolution using two-dimensional rational mutagenesis scanning
US20060020396A1 (en) * 2002-09-09 2006-01-26 Rene Gantier Rational directed protein evolution using two-dimensional rational mutagenesis scanning
AU2003263552A1 (en) * 2002-09-09 2004-03-29 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
WO2004048583A2 (fr) * 2002-11-22 2004-06-10 Institut Clayton De La Recherche Compositions et systemes destines a la regulation genique
WO2004073641A2 (fr) 2003-02-18 2004-09-02 Kevin Slawin Activation induite dans des cellules dendritiques
EP1603945A2 (fr) 2003-03-12 2005-12-14 Advisys, Inc. Suplementation d'igf-i avec mediation par plasmide pour applications therapeutiques
TW200424214A (en) * 2003-04-21 2004-11-16 Advisys Inc Plasmid mediated GHRH supplementation for renal failures
US20070224615A1 (en) * 2003-07-09 2007-09-27 Invitrogen Corporation Methods for assaying protein-protein interactions
CA2531698A1 (fr) 2003-07-09 2005-01-27 Sentigen Biosciences, Inc. Methode de detection d'une interaction proteine-proteine
KR101062140B1 (ko) 2003-07-21 2011-09-05 트랜스진 에스.에이. 향상된 시토신 디아미네이즈 활성을 갖는 폴리펩티드
WO2005047473A2 (fr) * 2003-11-10 2005-05-26 Emory University Bitherapie genique a un seul vecteur pour hypertension pulmonaire
EP1711187B1 (fr) 2003-12-31 2010-05-12 VGX Pharmaceuticals, LLC Reduction de l'arthrite et de la boiterie chez des sujets par apport complementaire de somatostatine (srif)
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
EP1910550A4 (fr) 2005-07-21 2009-11-04 Abbott Lab Expression multigenique comprenant des constructions sorf et methodes faisant appel a des polyproteines, a des pro-proteines, et a une proteolysis
US20070026012A1 (en) 2005-08-01 2007-02-01 Cornell Research Foundation, Inc. Compositions and methods for monitoring and altering protein folding and solubility
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
US20090317421A1 (en) 2006-01-18 2009-12-24 Dominique Missiakas Compositions and methods related to staphylococcal bacterium proteins
US20080096228A1 (en) * 2006-08-08 2008-04-24 The Regents Of The University Of California Compositions And Methods Relating To Mammalian Internal Ribosome Entry Sites
CN102026645B (zh) 2006-09-15 2016-01-27 渥太华医院研究机构 溶瘤弹状病毒
WO2008049113A2 (fr) 2006-10-19 2008-04-24 Baylor College Of Medicine Procédés et compositions pour générer une réponse immune en induisant des récepteurs cd40 et des récepteurs de reconnaissance de structures et des adaptateurs de ceux-ci
KR20080084528A (ko) 2007-03-15 2008-09-19 제네렉스 바이오테라퓨틱스 인크. 종양살상형 백시니아 바이러스 암 치료
CN101743306A (zh) 2007-03-23 2010-06-16 威斯康星校友研究基金会 体细胞重编程
EP2944649A1 (fr) 2008-01-10 2015-11-18 Research Development Foundation Vaccins et diagnostics pour les ehrlichioses
JP2011512877A (ja) * 2008-03-12 2011-04-28 ワイス・エルエルシー 組換えタンパク質の大スケール産生に適した細胞を同定する方法
US8450112B2 (en) 2008-04-09 2013-05-28 Maxcyte, Inc. Engineering and delivery of therapeutic compositions of freshly isolated cells
ES2587395T3 (es) 2008-06-04 2016-10-24 Cellular Dynamics International, Inc. Procedimientos para la producción de células IPS usando un enfoque no vírico
WO2010019569A1 (fr) 2008-08-12 2010-02-18 Cellular Dynamics International. Inc. Procédés de production de cellules ips
EP2328603A4 (fr) 2008-08-18 2013-01-02 Univ Maryland Dérivés d'apf et méthodes d'utilisation afférentes
AU2009292996B2 (en) 2008-09-22 2015-04-23 Baylor College Of Medicine Methods and compositions for generating an immune response by inducing CD40 and pattern recognition receptor adapters
EP2341929B1 (fr) 2008-10-06 2017-01-25 University Of Chicago Compositions et procédés associés aux protéines bactériennes emp
HUE057713T2 (hu) 2009-04-03 2022-05-28 Univ Chicago A protein A (SPA) variánsaival kapcsolatos készítmények és módszerek
CN102459575A (zh) 2009-06-05 2012-05-16 细胞动力国际有限公司 重编程t细胞和造血细胞的方法
ES2848650T3 (es) 2009-09-14 2021-08-11 Sillajen Biotherapeutics Inc Terapia combinada contra el cáncer con virus vaccinia oncolítico
CN102812040A (zh) * 2009-10-30 2012-12-05 雅培制药有限公司 Sorf构建体和多基因表达
AU2010329551B2 (en) 2009-12-10 2016-02-11 Turnstone Limited Partnership Oncolytic rhabdovirus
US10080799B2 (en) 2010-02-12 2018-09-25 Arizona Board Of Regents On Behalf Of Arizona State University Methods and compositions related to glycoprotein-immunoglobulin fusions
CA2793424A1 (fr) 2010-03-18 2011-09-22 Cornell University Preparation d'anticorps correctement plies utilisant la presentation sur la membrane interieure d'intermediaires de translocation twin-arginine
JP2013523818A (ja) 2010-04-05 2013-06-17 ザ・ユニバーシティー・オブ・シカゴ 免疫反応のエンハンサーとしてのプロテインＡ（ＳｐＡ）抗体に関連する組成物および方法
WO2011133512A1 (fr) 2010-04-19 2011-10-27 Research Development Foundation Variants de rtef-1 et utilisations de ceux-ci
US9089520B2 (en) 2010-05-21 2015-07-28 Baylor College Of Medicine Methods for inducing selective apoptosis
US20110312001A1 (en) 2010-06-15 2011-12-22 Emile Nuwaysir Compendium of ready-built stem cell models for interrogation of biological response
JP5984217B2 (ja) 2010-06-15 2016-09-06 セルラー ダイナミクス インターナショナル， インコーポレイテッド 少量の末梢血からの人工多能性幹細胞の作製
WO2012003474A2 (fr) 2010-07-02 2012-01-05 The University Of Chicago Compositions et méthodes associées à des variants de protéine a (spa)
JP5897002B2 (ja) 2010-07-07 2016-04-13 セルラー ダイナミクス インターナショナル， インコーポレイテッド プログラミングによる内皮細胞の産生
EP2601289B1 (fr) 2010-08-04 2017-07-12 Cellular Dynamics International, Inc. Reprogrammation des lymphocytes b immortalisés
EP2613791A4 (fr) 2010-09-08 2015-05-13 Univ Texas Thérapie anticancéreuse sur la base des récepteurs de la somatostatine
US9095540B2 (en) 2010-09-09 2015-08-04 The University Of Chicago Methods and compositions involving protective staphylococcal antigens
EP2625271B1 (fr) * 2010-10-04 2017-05-31 Tree of Knowledge Patents B.V. Méthode d'extraction d'adn de cellules végétales et de nématodes
CN103429258B (zh) 2011-01-04 2016-03-09 新罗杰公司 通过施用溶瘤痘苗病毒生成针对肿瘤抗原的抗体和生成肿瘤特异性补体依赖性细胞毒性
WO2012098260A1 (fr) 2011-01-21 2012-07-26 Axiogenesis Ag Système non viral pour générer des cellules souches pluripotentes induites (ips)
JP6005666B2 (ja) 2011-02-08 2016-10-12 セルラー ダイナミクス インターナショナル， インコーポレイテッド プログラミングによる造血前駆細胞の生産
US9085631B2 (en) 2011-04-08 2015-07-21 Nov Vac APS Proteins and nucleic acids useful in vaccines targeting Staphylococcus aureus
US8945588B2 (en) 2011-05-06 2015-02-03 The University Of Chicago Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides
WO2012167382A1 (fr) 2011-06-08 2012-12-13 Children's Hospital Of Eastern Ontario Research Institute Inc. Compositions et procédés pour le traitement du glioblastome
CA2841165A1 (fr) 2011-07-11 2013-01-17 Cellular Dynamics International, Inc. Procedes de reprogrammation cellulaire et d'ingenierie genomique
WO2013026015A1 (fr) 2011-08-18 2013-02-21 Dana-Farber Cancer Institute, Inc. Pièges de ligand de muc1 pour l'utilisation dans le traitement de cancers
US9273102B2 (en) 2011-10-12 2016-03-01 Niels Iversen Møller Peptides derived from Campylobacter jejuni and their use in vaccination
CN110042086A (zh) 2012-02-02 2019-07-23 得克萨斯州大学系统董事会 表达异源肿瘤相关抗原的腺病毒
WO2013162746A1 (fr) 2012-04-26 2013-10-31 University Of Chicago Antigènes des staphylocoques coagulase et leurs méthodes d'utilisation
US10125373B2 (en) 2013-01-22 2018-11-13 Arizona Board Of Regents On Behalf Of Arizona State University Geminiviral vector for expression of rituximab
RU2684211C2 (ru) 2013-02-21 2019-04-04 Тёрнстоун Лимитед Партнершип Композиция вакцины
US20140242595A1 (en) 2013-02-22 2014-08-28 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
US20160010094A1 (en) 2013-03-01 2016-01-14 University Of Pretoria Transgenic cell selection
US9434935B2 (en) 2013-03-10 2016-09-06 Bellicum Pharmaceuticals, Inc. Modified caspase polypeptides and uses thereof
KR20150131218A (ko) 2013-03-14 2015-11-24 벨리쿰 파마슈티컬스, 인크. T 세포 증식의 제어 방법
EP3569253A1 (fr) 2013-06-05 2019-11-20 Bellicum Pharmaceuticals, Inc. Procédés permettant d'induire une apoptose partielle en utilisant des polypeptides de caspase
WO2015035395A1 (fr) 2013-09-09 2015-03-12 Figene, Llc Thérapie génique pour la régénération de cellules de type chondrocytes ou cartilagineuses
US20170002064A1 (en) 2013-11-08 2017-01-05 The Board Of Regents Of The University Of Texas System Vh4 antibodies against gray matter neuron and astrocyte
WO2015070050A1 (fr) 2013-11-08 2015-05-14 Baylor Research Institute La localisation nucléaire de glp-1 stimule la régénération myocardique et entraîne la régression d'une insuffisance cardiaque
SG10201907841UA (en) 2013-11-22 2019-10-30 Dnatrix Inc Adenovirus expressing immune cell stimulatory receptor agonist(s)
EP4227685A3 (fr) 2013-12-03 2024-02-28 Evaxion Biotech A/S Proteines et acides nucleiques utiles dans des vaccins ciblant staphylococcus aureus
JP6908381B2 (ja) 2014-01-29 2021-07-28 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Ｍｕｃ１−ｃ／細胞外ドメイン（ｍｕｃ１−ｃ／ｅｃｄ）に対する抗体
EP3104866A4 (fr) 2014-02-14 2017-08-02 Bellicum Pharmaceuticals, Inc. Méthodes d'activation des lymphocytes t à l'aide d'un polypeptide chimère inductible
WO2015157636A1 (fr) 2014-04-10 2015-10-15 H. Lee Moffitt Cancer Center And Research Institute, Inc. Expansion améliorée des lymphocytes infiltrants des tumeurs pour thérapie cellulaire adoptive
WO2015164228A1 (fr) 2014-04-21 2015-10-29 Cellular Dynamics International, Inc. Production d'hépatocytes par programmation progressive par génie génétique et chimique combinés
US20170137800A1 (en) 2014-07-08 2017-05-18 The Children's Medical Center Corporation Compositions and methods for treating diabetes
AU2015312117A1 (en) 2014-09-02 2017-03-02 Bellicum Pharmaceuticals, Inc. Costimulation of chimeric antigen receptors by Myd88 and CD40 polypeptides
ES2904301T3 (es) 2014-11-03 2022-04-04 Academisch Ziekenhuis Leiden H O D N Leids Univ Medisch Centrum Receptores de células T dirigidos contra Bob1 y usos de los mismos
US20180169211A1 (en) 2014-11-13 2018-06-21 Evaxion Biotech Aps Peptides derived from acinetobacter baumannii and their use in vaccination
EP3224362A4 (fr) 2014-11-26 2018-06-06 The Regents of The University of California Compositions thérapeutiques comprenant des facteurs de transcription et leurs procédés de préparation et d'utilisation
DK3234145T3 (da) 2014-12-15 2019-08-19 Bellicum Pharmaceuticals Inc Fremgangsmåde til kontrollered aktivering eller eliminering af terapeutiske celler
US10434162B2 (en) 2015-01-12 2019-10-08 Evaxion Biotech Aps Proteins and nucleic acids useful in vaccines targeting Klebsiella pneumoniae
WO2016134293A1 (fr) 2015-02-20 2016-08-25 Baylor College Of Medicine Inactivation de p63 pour le traitement de l'insuffisance cardiaque
EP4201955A1 (fr) 2015-03-10 2023-06-28 Academisch Ziekenhuis Leiden H.O.D.N. Leids Universitair Medisch Centrum Récepteurs de lymphocytes t dirigés contre l'antigène exprimé préférentiellement du mélanome et leurs utilisations
WO2017005670A1 (fr) 2015-07-04 2017-01-12 Evaxion Biotech Aps Protéines et acides nucléiques utiles dans des vaccins ciblant pseudomonas aeruginosa
WO2017070337A1 (fr) 2015-10-20 2017-04-27 Cellular Dynamics International, Inc. Procédés de différenciation dirigée de cellules souches pluripotentes en cellules immunes
WO2017075395A1 (fr) 2015-10-28 2017-05-04 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Vecteurs adénoviraux à spécificité tumorale et leurs utilisations thérapeutiques
AU2016343682A1 (en) 2015-10-30 2018-06-14 The Regents Of The University Of California Methods of generating T-cells from stem cells and immunotherapeutic methods using the T-cells
WO2017079202A1 (fr) 2015-11-02 2017-05-11 Board Of Regents, The University Of Texas System Méthodes d'activation de cd40 et blocage de points de contrôle immunitaires
WO2017079746A2 (fr) 2015-11-07 2017-05-11 Multivir Inc. Méthodes et compositions comprenant une thérapie génique suppressive de tumeur et le blocage du point de contrôle immunitaire pour le traitement du cancer
CA3004438A1 (fr) 2015-11-09 2017-05-18 The Children's Hospital Of Philadelphia Glypicane 2 a utiliser en tant que marqueur cancereux et cible therapeutique
WO2017144523A1 (fr) 2016-02-22 2017-08-31 Evaxion Biotech Aps Protéines et acides nucléiques utiles dans des vaccins ciblant staphylococcus aureus
CA3019635A1 (fr) 2016-03-31 2017-10-05 Baylor Research Institute Proteine 8 de type angiopoietine (angptl8)
EP3463449A1 (fr) 2016-05-27 2019-04-10 ALK-Abelló A/S Protéines immunogènes et fragments de celles-ci à partir d'acariens allergènes
WO2017216384A1 (fr) 2016-06-17 2017-12-21 Evaxion Biotech Aps Vaccination ciblant ichthyophthirius multifiliis
WO2017220787A1 (fr) 2016-06-24 2017-12-28 Evaxion Biotech Aps Vaccin contre l'infection provoquée par aeromonas salmonicida
EP3478325A4 (fr) 2016-07-01 2020-01-15 Research Development Foundation Élimination de cellules proliférantes de greffons dérivés de cellules souches
EP3487872A1 (fr) 2016-07-22 2019-05-29 Evaxion Biotech ApS Protéines chimériques pour induire une immunité vis-à-vis d'une infection à s. aureus
AU2017340644B2 (en) 2016-10-05 2024-05-09 Fujifilm Cellular Dynamics Inc Methods for directed differentiation of pluripotent stem cells to HLA homozygous immune cells
CN110199020A (zh) 2016-11-03 2019-09-03 坦普尔大学-高等教育联盟 用于快速产生用于细胞系开发的同源重组载体的dna质粒
CN109996809A (zh) 2016-11-14 2019-07-09 诺华股份有限公司 与促融合蛋白minion相关的组合物、方法和治疗用途
WO2018111902A1 (fr) 2016-12-12 2018-06-21 Multivir Inc. Méthodes et compositions comprenant une thérapie génique virale et un inhibiteur de point de contrôle immunitaire pour le traitement et la prévention du cancer et des maladies infectieuses
US11298420B2 (en) 2016-12-21 2022-04-12 Memgen, Llc Armed oncolytic viruses
EP3565578A1 (fr) 2016-12-21 2019-11-13 Memgen LLC Adénovirus oncolytiques armés aptes à la réplication
US11718648B2 (en) 2017-01-05 2023-08-08 Evaxion Biotech A/S Vaccines targeting Pseudomonas aeruginosa
DE102017103383A1 (de) 2017-02-20 2018-08-23 aReNA-Bio GbR (vertretungsberechtigter Gesellschafter: Dr. Heribert Bohlen, 50733 Köln) System und Verfahren zur Zelltyp-spezifischen Translation von RNA-Molekülen in Eukaryoten
EP3385373A1 (fr) 2017-04-05 2018-10-10 Centro de Neurociências e Biologia Celular Compositions pour la reprogrammation de cellules en cellules dendritiques ou en cellules présentatrices d'antigènes, leurs procédés et utilisations
CN110088272B (zh) 2017-04-05 2023-08-04 阿斯加德治疗有限公司 用于将细胞重编程为树突状细胞或抗原呈递细胞的组合物、其方法和用途
ES2912383T3 (es) 2017-04-18 2022-05-25 Fujifilm Cellular Dynamics Inc Células efectoras inmunitarias específicas de antígeno
EP3621988A1 (fr) 2017-05-09 2020-03-18 Bellicum Pharmaceuticals, Inc. Procédés pour augmenter ou modifier la transduction de signal
CN110945018A (zh) 2017-07-27 2020-03-31 诺华股份有限公司 抗脱落酶的trem2变体
EP3710466A2 (fr) 2017-11-13 2020-09-23 The University of Chicago Méthodes et compositions pour le traitement des plaies
WO2019145399A1 (fr) 2018-01-24 2019-08-01 Evaxion Biotech Aps Vaccins pour la prophylaxie d'infections par s. aureus
EP3768698A4 (fr) 2018-03-19 2022-03-30 MultiVir Inc. Procédés et compositions comprenant une thérapie génique suppressive de tumeur et des agonistes de cd122/cd132 pour le traitement du cancer
US11413336B2 (en) 2018-03-23 2022-08-16 Board Of Regents, The University Of Texas System Coccidioides antigens and methods of their use
WO2019211320A1 (fr) 2018-05-01 2019-11-07 Orfoneuro Aps Traitement de la céroïde-lipofuscinose neuronale
BR112021003897A2 (pt) 2018-08-30 2021-05-25 Tenaya Therapeutics, Inc. reprogramação de células cardíacas com miocarina e asci1
WO2020083904A1 (fr) 2018-10-22 2020-04-30 Evaxion Biotech Aps Vaccins ciblant m. catharrhalis
EP3930687A4 (fr) 2019-02-25 2023-06-07 The University of Chicago Méthodes et compositions destinées au traitement de maladies auto-immunes et inflammatoires faisant intervenir des peptides à affinité pour la matrice extracellulaire liés à des agents anti-inflammatoires
WO2020174044A1 (fr) 2019-02-27 2020-09-03 Evaxion Biotech Aps Vaccins ciblant h. influenzae
EP3997226A1 (fr) 2019-07-11 2022-05-18 Tenaya Therapeutics, Inc. Reprogrammation de cellules cardiaques avec des microarn et d'autres facteurs
JP2022541538A (ja) 2019-07-19 2022-09-26 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア グリピカン２結合ドメインを含有するキメラ抗原受容体
WO2021048381A1 (fr) 2019-09-13 2021-03-18 Evaxion Biotech Aps Procédé d'identification de peptides de liaison au cmh stable par spectrométrie de masse
WO2021048400A1 (fr) 2019-09-13 2021-03-18 Evaxion Biotech Aps Procédé d'identification d'épitopes de lymphocytes t
WO2021113644A1 (fr) 2019-12-05 2021-06-10 Multivir Inc. Combinaisons comprenant un activateur de lymphocytes t cd8+, un inhibiteur de point de contrôle immunitaire et une radiothérapie en vue d'obtenir des effets ciblés et abscopal pour le traitement du cancer
EP4087593A1 (fr) 2020-01-06 2022-11-16 Evaxion Biotech A/S Vaccins ciblant neisseria gonorrhoeae
EP4114421A1 (fr) 2020-03-02 2023-01-11 Tenaya Therapeutics, Inc. Régulation de vecteur génique au moyen de micro-arn exprimés par des cardiomyocytes
US20230211023A1 (en) 2020-03-25 2023-07-06 Erasmus University Medical Center Rotterdam Reporter system for radionuclide imaging
CA3178949A1 (fr) 2020-05-29 2021-12-02 Andrew DIAS Agregats cellulaires doubles de photorecepteurs et d'epithelium pigmente retinien et leurs procedes d'utilisation
CA3180561A1 (fr) 2020-05-29 2021-12-02 Andrew DIAS Bicouche d'epithelium pigmentaire retinien et de photorecepteurs et son utilisation
AU2021360902A1 (en) 2020-10-15 2023-04-27 Aavocyte, Inc. Recombinant adeno-associated virus vectors with cd14 promoter and use thereof
EP4291216A1 (fr) 2021-02-09 2023-12-20 University of Houston System Virus oncolytique pour administration systémique et les activités anti-tumorales améliorées
CA3216719A1 (fr) 2021-05-03 2022-11-10 Astellas Institute For Regenerative Medicine Procedes de generation de cellules endotheliales corneennes matures
KR20240005887A (ko) 2021-05-07 2024-01-12 아스텔라스 인스티튜트 포 리제너러티브 메디슨 성숙한 간세포를 발생시키는 방법
WO2022248531A1 (fr) 2021-05-26 2022-12-01 Evaxion Biotech A/S Vaccination ciblant des pathogènes intracellulaires
KR20240011831A (ko) 2021-05-26 2024-01-26 후지필름 셀룰러 다이내믹스, 인코포레이티드 만능 줄기 세포에서 유전자의 신속한 사일런싱을 방지하기 위한 방법
CA3224564A1 (fr) 2021-07-05 2023-01-12 Andreas Holm MATTSSON Vaccins ciblant neisseria gonorrhoeae
WO2023148398A1 (fr) 2022-02-07 2023-08-10 Var2 Pharmaceuticals Aps Anticorps et fragments d'anticorps et analogues specifiques du sulfate de chondroïtine
WO2023178191A1 (fr) 2022-03-16 2023-09-21 University Of Houston System Système d'administration de gène hsv persistant
WO2023201207A1 (fr) 2022-04-11 2023-10-19 Tenaya Therapeutics, Inc. Virus adéno-associé comprenant une capside modifiée
WO2023213393A1 (fr) 2022-05-04 2023-11-09 Evaxion Biotech A/S Variants de protéine staphylococcique et parties tronquées
WO2024006911A1 (fr) 2022-06-29 2024-01-04 FUJIFILM Holdings America Corporation Astrocytes dérivés d'ipsc et leurs procédés d'utilisation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007950A1 (fr) * 1990-10-25 1992-05-14 Clague Pitman Hodgson Procede de transfert de genes au moyen de retrotransposons
WO1993003143A1 (fr) * 1991-08-07 1993-02-18 Anderson W French Vecteurs retroviraux contenant des sites internes d'entree de ribosome

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007950A1 (fr) * 1990-10-25 1992-05-14 Clague Pitman Hodgson Procede de transfert de genes au moyen de retrotransposons
WO1993003143A1 (fr) * 1991-08-07 1993-02-18 Anderson W French Vecteurs retroviraux contenant des sites internes d'entree de ribosome

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ADAMS, S. ET AL.: "Complete nucleotide sequence of a mouse VL30 retro-element", MOLECULAR AND CELLULAR BIOLOGY, vol. 8, no. 8, WASHINGTON US, pages 2989 - 2998 *
HODGSON, C. ET AL.: "Expression of VL30 vectors in primary cell types which are targets for gene therapy", KEYSTONE SYMPOSIUM ON GENE THERAPY AND MOLECULAR MEDICINE, STEAMBOAT SPRINGS, COLORADO, USA, MARCH 26-APRIL 1, 1995. JOURNAL OF CELLULAR BIOCHEMISTRY SUPPLEMENT 0 (21A). 1995. 408 *
HODGSON, C. ET AL.: "Nucleotide sequence of mouse virus-like (VL30) retrotransposon BVL-1", NUCLEIC ACIDS RESEARCH, vol. 18, no. 3, OXFORD GB, pages 673 *
HOMANN, H. ET AL.: "New generation of safe, efficient retroviral vectors and packaging cell lines for application in gene therapy trials.", KEYSTONE SYMPOSIUM ON GENE THERAPY AND MOLECULAR MEDICINE, STEAMBOAT SPRINGS, COLORADO, USA, MARCH 26-APRIL 1, 1995. JOURNAL OF CELLULAR BIOCHEMISTRY SUPPLEMENT 0 (21A). 1995. 408 *
TORRENT, C. ET AL.: "A small and efficient dimerization/packaging signal of rat VL30 RNA and its use in murine leukemia virus-VL30-derived vectors for gene transfer", JOURNAL OF VIROLOGY, vol. 68, no. 2, pages 661 - 667 *
TORRENT, C. ET AL.: "Analytical study of rat retrotransposon VL30 RNA dimerization in vitro and packaging in murine leukemia virus.", JOURNAL OF MOLECULAR BIOLOGY 240 (5). 1994. 434-444 *

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