DE60045350D1 - Zusammensetzungen und verfahren zur therapeutischen anwendung einer mit dem gen atonal assoziierten sequenz - Google Patents

Zusammensetzungen und verfahren zur therapeutischen anwendung einer mit dem gen atonal assoziierten sequenz

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Publication number
DE60045350D1
DE60045350D1 DE60045350T DE60045350T DE60045350D1 DE 60045350 D1 DE60045350 D1 DE 60045350D1 DE 60045350 T DE60045350 T DE 60045350T DE 60045350 T DE60045350 T DE 60045350T DE 60045350 D1 DE60045350 D1 DE 60045350D1
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Prior art keywords
atonal
nucleic acid
compositions
methods
gen
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Expired - Lifetime
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DE60045350T
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English (en)
Inventor
Huda Y Zoghbi
Hugo Bellen
Nessan Birmingham
Bassem Hassan
Nissim Ben-Arie
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Baylor College of Medicine
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Baylor College of Medicine
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K2227/10—Mammal
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    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE60045350T 1999-06-01 2000-06-01 Zusammensetzungen und verfahren zur therapeutischen anwendung einer mit dem gen atonal assoziierten sequenz Expired - Lifetime DE60045350D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13706099P 1999-06-01 1999-06-01
US17699300P 2000-01-19 2000-01-19
PCT/US2000/015410 WO2000073764A2 (en) 1999-06-01 2000-06-01 Composition and methods for the therapeutic use of an atonal-associated sequence

Publications (1)

Publication Number Publication Date
DE60045350D1 true DE60045350D1 (de) 2011-01-20

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DE60045350T Expired - Lifetime DE60045350D1 (de) 1999-06-01 2000-06-01 Zusammensetzungen und verfahren zur therapeutischen anwendung einer mit dem gen atonal assoziierten sequenz

Country Status (11)

Country Link
US (3) US6838444B1 (de)
EP (2) EP2325198A1 (de)
JP (4) JP2003530817A (de)
AT (1) ATE490777T1 (de)
AU (1) AU781802B2 (de)
CA (1) CA2375106C (de)
CY (1) CY1111499T1 (de)
DE (1) DE60045350D1 (de)
DK (1) DK1471926T3 (de)
PT (1) PT1471926E (de)
WO (1) WO2000073764A2 (de)

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US7053200B1 (en) * 1999-06-01 2006-05-30 Baylor College Of Medicine Compositions and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis, and abnormal cell proliferation
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US20040166091A1 (en) * 2003-02-24 2004-08-26 Genvec, Inc. Materials and methods for treating disorders of the ear
US8673634B2 (en) * 2003-11-13 2014-03-18 Massachusetts Eye & Ear Infirmary Method for the treatment of hearing loss
US20050221429A1 (en) * 2004-01-16 2005-10-06 Cardinal Health Pts, Llc Host cells containing multiple integrating vectors comprising an amplifiable marker
US8260401B2 (en) * 2006-07-26 2012-09-04 University Of Rochester Non-invasive in-vivo imaging of mechanoreceptors in skin using confocal microscopy
EP2094836B1 (de) 2006-11-15 2016-06-08 Massachusetts Eye & Ear Infirmary Erzeugung von innerohrzellen
CN101990433B (zh) * 2008-02-07 2014-11-05 马萨诸塞眼科耳科诊所 提高Atoh1表达的化合物
WO2012010675A2 (en) * 2010-07-21 2012-01-26 Universite Montpellier 2 Sciences Et Techniques Bhlh proteins and their use as drugs
WO2012121167A1 (ja) * 2011-03-04 2012-09-13 日本電気株式会社 個体識別システム、個体識別方法及びそれらに用いられる装置、プログラム
CN102659951A (zh) * 2012-05-29 2012-09-12 西安医学院 一种TAT结构域修饰的neurogenin2融合蛋白制备方法和用途
US20140134136A1 (en) * 2012-11-02 2014-05-15 Massachusetts Eye And Ear Infirmary Compositions and methods for auditory therapy
US9572815B2 (en) 2013-03-15 2017-02-21 St. Jude Children's Research Hospital Methods and compositions of p27KIP1 transcriptional modulators
TWI710635B (zh) * 2014-10-09 2020-11-21 美商珍維克公司 編碼人類無調同源物-1(hath1)之腺病毒載體
US11370823B2 (en) 2014-10-29 2022-06-28 Massachusetts Eye And Ear Infirmary Efficient delivery of therapeutic molecules to cells of the inner ear
JP6902025B2 (ja) 2015-06-18 2021-07-14 ティン セラピューティックス エルエルシー 聴覚損失の予防および治療のための方法および組成物
WO2017087866A1 (en) 2015-11-20 2017-05-26 Grand Valley State University Nato3 mutant polypeptides and uses thereof
WO2018148071A1 (en) * 2017-02-10 2018-08-16 St. Jude Children's Research Hospital Combination therapy for treating disorders of the ear
EP3743057A4 (de) 2018-01-26 2021-11-17 Massachusetts Eye & Ear Infirmary Behandlung von hörverlust
CN116178537A (zh) * 2022-12-01 2023-05-30 福州迈新生物技术开发有限公司 抗Calretinin蛋白的单克隆抗体及其细胞株、制备方法和应用

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EP1471926B1 (de) 2010-12-08
JP2003530817A (ja) 2003-10-21
JP2011062204A (ja) 2011-03-31
CA2375106C (en) 2014-08-19
US20040237127A1 (en) 2004-11-25
WO2000073764A3 (en) 2004-05-27
US7470673B2 (en) 2008-12-30
US6838444B1 (en) 2005-01-04
AU5595900A (en) 2000-12-18
PT1471926E (pt) 2011-03-11
AU781802B2 (en) 2005-06-16
CY1111499T1 (el) 2015-08-05
JP2017006119A (ja) 2017-01-12
EP1471926A4 (de) 2004-11-03
US7442688B2 (en) 2008-10-28
ATE490777T1 (de) 2010-12-15
EP2325198A1 (de) 2011-05-25
DK1471926T3 (da) 2011-02-28
EP1471926A2 (de) 2004-11-03
US20040231009A1 (en) 2004-11-18
WO2000073764A2 (en) 2000-12-07
CA2375106A1 (en) 2000-12-07
JP2014147387A (ja) 2014-08-21

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