UY24438A1 - Procedimiento de preparacion de enantiomeros de o-demetiltramadol - Google Patents
Procedimiento de preparacion de enantiomeros de o-demetiltramadolInfo
- Publication number
- UY24438A1 UY24438A1 UY24438A UY24438A UY24438A1 UY 24438 A1 UY24438 A1 UY 24438A1 UY 24438 A UY24438 A UY 24438A UY 24438 A UY24438 A UY 24438A UY 24438 A1 UY24438 A1 UY 24438A1
- Authority
- UY
- Uruguay
- Prior art keywords
- enantiomer
- tramadol
- enantiomers
- free base
- demethyltramadol
- Prior art date
Links
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 abstract 8
- 229960004380 tramadol Drugs 0.000 abstract 8
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 abstract 8
- 239000012458 free base Substances 0.000 abstract 4
- UWJUQVWARXYRCG-UHFFFAOYSA-N o-desmethyltramadol Chemical compound CN(C)CC1CCCCC1(O)C1=CC=CC(O)=C1 UWJUQVWARXYRCG-UHFFFAOYSA-N 0.000 abstract 3
- 239000012452 mother liquor Substances 0.000 abstract 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 1
- FGCFTLWVTWVAPJ-UHFFFAOYSA-N 1-(3-methoxyphenyl)cyclohexan-1-ol Chemical compound COC1=CC=CC(C2(O)CCCCC2)=C1 FGCFTLWVTWVAPJ-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- 235000011002 L(+)-tartaric acid Nutrition 0.000 abstract 1
- 239000001358 L(+)-tartaric acid Substances 0.000 abstract 1
- FEWJPZIEWOKRBE-LWMBPPNESA-N L-(+)-Tartaric acid Natural products OC(=O)[C@@H](O)[C@H](O)C(O)=O FEWJPZIEWOKRBE-LWMBPPNESA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- AZWXAPCAJCYGIA-UHFFFAOYSA-N bis(2-methylpropyl)alumane Chemical compound CC(C)C[AlH]CC(C)C AZWXAPCAJCYGIA-UHFFFAOYSA-N 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19601744A DE19601744C2 (de) | 1996-01-19 | 1996-01-19 | Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY24438A1 true UY24438A1 (es) | 1997-01-10 |
Family
ID=7783111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY24438A UY24438A1 (es) | 1996-01-19 | 1997-01-10 | Procedimiento de preparacion de enantiomeros de o-demetiltramadol |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US5728885A (enExample) |
| EP (1) | EP0786450B1 (enExample) |
| JP (1) | JPH09216857A (enExample) |
| KR (1) | KR100507396B1 (enExample) |
| CN (1) | CN1073085C (enExample) |
| AR (1) | AR005390A1 (enExample) |
| AT (1) | ATE191454T1 (enExample) |
| AU (1) | AU705195B2 (enExample) |
| BR (1) | BR9700079A (enExample) |
| CA (1) | CA2195372C (enExample) |
| CO (1) | CO4520186A1 (enExample) |
| CZ (1) | CZ292427B6 (enExample) |
| DE (2) | DE19601744C2 (enExample) |
| DK (1) | DK0786450T3 (enExample) |
| ES (1) | ES2147341T3 (enExample) |
| GR (1) | GR3033390T3 (enExample) |
| HU (1) | HU223661B1 (enExample) |
| IL (1) | IL120029A (enExample) |
| IN (1) | IN181540B (enExample) |
| MY (1) | MY116593A (enExample) |
| NO (1) | NO306943B1 (enExample) |
| NZ (1) | NZ299998A (enExample) |
| PE (1) | PE29998A1 (enExample) |
| PL (1) | PL187373B1 (enExample) |
| PT (1) | PT786450E (enExample) |
| RU (1) | RU2185371C2 (enExample) |
| SI (1) | SI0786450T1 (enExample) |
| SK (1) | SK282629B6 (enExample) |
| UA (1) | UA45342C2 (enExample) |
| UY (1) | UY24438A1 (enExample) |
| ZA (1) | ZA97367B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19712398A1 (de) * | 1997-03-25 | 1998-10-01 | Gruenenthal Gmbh | Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel |
| PE20010623A1 (es) | 1999-10-05 | 2001-07-07 | Gruenenthal Chemie | Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria |
| US6297286B1 (en) * | 1999-11-09 | 2001-10-02 | Darwin Discovery, Ltd. | Therapeutic use and formulation |
| DE10049483A1 (de) * | 2000-09-29 | 2002-05-02 | Gruenenthal Gmbh | Substituierte 1-Aminobutan-3-ol-Derivate |
| DE10108122A1 (de) | 2001-02-21 | 2002-10-02 | Gruenenthal Gmbh | Arzneimittel auf Basis von Tramadol |
| DE10108123A1 (de) * | 2001-02-21 | 2002-10-02 | Gruenenthal Gmbh | Wirkstoffkombination |
| DE10109763A1 (de) * | 2001-02-28 | 2002-09-05 | Gruenenthal Gmbh | Pharmazeutische Salze |
| US20050176790A1 (en) | 2001-02-28 | 2005-08-11 | Johannes Bartholomaus | Pharmaceutical salts |
| NZ528935A (en) | 2001-03-16 | 2004-10-29 | Dmi Biosciences Inc | Method of delaying ejaculation |
| US6649783B2 (en) * | 2001-10-03 | 2003-11-18 | Euro-Celtique, S.A. | Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols |
| AU2002364517A1 (en) | 2001-11-30 | 2003-06-17 | Sepracor Inc. | Tramadol analogs and uses thereof |
| US20040248979A1 (en) * | 2003-06-03 | 2004-12-09 | Dynogen Pharmaceuticals, Inc. | Method of treating lower urinary tract disorders |
| DE102005033732B4 (de) * | 2005-05-27 | 2014-02-13 | Grünenthal GmbH | Trennung stereoisomerer N,N-Dialkylamino-2-alkyl-3-hydroxy-3-phenyl-alkane |
| EP1785412A1 (en) * | 2005-11-14 | 2007-05-16 | IPCA Laboratories Limited | Tramadol recovery process |
| US20080261991A1 (en) | 2007-02-12 | 2008-10-23 | Dmi Biosciences, Inc. | Reducing Side Effects of Tramadol |
| JP2010518167A (ja) | 2007-02-12 | 2010-05-27 | ディーエムアイ バイオサイエンシズ インコーポレイテッド | 併存する早漏及び勃起障害の治療 |
| US20110251286A1 (en) * | 2010-03-10 | 2011-10-13 | Gruenenthal Gmbh | Crystalline salts and/or co-crystals of O-desmethyltramadol |
| EP2383255A1 (en) | 2010-04-28 | 2011-11-02 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
| EP2530072A1 (en) | 2011-06-03 | 2012-12-05 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
| US10702485B2 (en) | 2011-07-09 | 2020-07-07 | Syntrix Biosystems Inc. | Compositions and methods for overcoming resistance to tramadol |
| WO2019053494A1 (en) | 2017-09-18 | 2019-03-21 | R L Fine Chem Private Limited | PROCESS FOR THE PREPARATION OF O-DESMETHYLTRAMADOL AND SALTS THEREOF |
| US11000488B2 (en) | 2019-03-22 | 2021-05-11 | Syntrix Biosystems Inc. | Treating pain using desmetramadol |
| CN118108610B (zh) * | 2024-04-30 | 2025-01-10 | 山东新华制药股份有限公司 | 盐酸去甲曲马多的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1518663A1 (de) * | 1965-08-02 | 1969-12-18 | Gruenenthal Chemie | Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung |
| US3652589A (en) * | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
| US3652289A (en) * | 1970-07-20 | 1972-03-28 | Eastman Kodak Co | Silver halide emulsions and elements comprising trimethine hemioxonal dyes |
| DE69215316T2 (de) | 1991-09-06 | 1997-03-20 | Mcneilab Inc | Zusammensetzungen, die Tramadol und irgendein Kodein, Oxykoden oder Hydrokoden enthalten, und deren Verwendung |
| DE122004000032I2 (de) | 1991-09-06 | 2006-02-09 | Mcneilab Inc | Zusammensetzung die eine Tramadol-Verbindung und Acetaminophen enth{lt, und ihre Verwendung |
| JPH06122686A (ja) * | 1992-10-12 | 1994-05-06 | Fujisawa Pharmaceut Co Ltd | ラセミ体の光学分割法 |
-
1996
- 1996-01-19 DE DE19601744A patent/DE19601744C2/de not_active Expired - Fee Related
- 1996-12-18 PE PE1996000931A patent/PE29998A1/es not_active Application Discontinuation
- 1996-12-21 DK DK96120727T patent/DK0786450T3/da active
- 1996-12-21 SI SI9630187T patent/SI0786450T1/xx unknown
- 1996-12-21 PT PT96120727T patent/PT786450E/pt unknown
- 1996-12-21 ES ES96120727T patent/ES2147341T3/es not_active Expired - Lifetime
- 1996-12-21 EP EP96120727A patent/EP0786450B1/de not_active Expired - Lifetime
- 1996-12-21 DE DE59604885T patent/DE59604885D1/de not_active Expired - Lifetime
- 1996-12-21 AT AT96120727T patent/ATE191454T1/de active
- 1996-12-23 NZ NZ299998A patent/NZ299998A/en not_active IP Right Cessation
- 1996-12-30 MY MYPI96005545A patent/MY116593A/en unknown
- 1996-12-30 CO CO96068522A patent/CO4520186A1/es unknown
-
1997
- 1997-01-07 AR ARP970100068A patent/AR005390A1/es active IP Right Grant
- 1997-01-09 IN IN46CA1997 patent/IN181540B/en unknown
- 1997-01-10 BR BR9700079A patent/BR9700079A/pt not_active Application Discontinuation
- 1997-01-10 UY UY24438A patent/UY24438A1/es not_active IP Right Cessation
- 1997-01-16 HU HU9700140A patent/HU223661B1/hu not_active IP Right Cessation
- 1997-01-16 ZA ZA97367A patent/ZA97367B/xx unknown
- 1997-01-17 CA CA002195372A patent/CA2195372C/en not_active Expired - Fee Related
- 1997-01-17 IL IL12002997A patent/IL120029A/xx not_active IP Right Cessation
- 1997-01-17 US US08/784,078 patent/US5728885A/en not_active Expired - Lifetime
- 1997-01-17 KR KR1019970001204A patent/KR100507396B1/ko not_active Expired - Fee Related
- 1997-01-17 NO NO970212A patent/NO306943B1/no not_active IP Right Cessation
- 1997-01-17 CN CN97102072A patent/CN1073085C/zh not_active Expired - Fee Related
- 1997-01-17 JP JP9006904A patent/JPH09216857A/ja not_active Ceased
- 1997-01-17 SK SK67-97A patent/SK282629B6/sk not_active IP Right Cessation
- 1997-01-17 UA UA97010174A patent/UA45342C2/uk unknown
- 1997-01-17 PL PL97318002A patent/PL187373B1/pl not_active IP Right Cessation
- 1997-01-17 AU AU12216/97A patent/AU705195B2/en not_active Ceased
- 1997-01-17 CZ CZ1997157A patent/CZ292427B6/cs not_active IP Right Cessation
- 1997-01-17 RU RU97100984/04A patent/RU2185371C2/ru not_active IP Right Cessation
-
2000
- 2000-05-09 GR GR20000401077T patent/GR3033390T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UY24439A1 (es) | Un procedimiento para el desdoblamiento de los racematos del tramadol | |
| AR005390A1 (es) | Procedimiento de preparacion de enantiomeros de o-demetiltramadol | |
| RU97100984A (ru) | Способ получения энантиомеров o-диметилтрамадола | |
| AR042546A1 (es) | Procedimiento de preparacion y formas cristalinas de los enantiomeros de modafinil, composiciones farmaceuticas y medicamentos que los contienen | |
| PT1657243E (pt) | Processo para a produção de aminoálcoois | |
| JPH09216858A5 (enExample) | ||
| ES2087790T3 (es) | Un procedimiento para la produccion de dimeros de cetena. | |
| AR044296A1 (es) | Metodo para la racemizacion de la (s) - (+) y de la (r) - (-) -10, 11-dihidro-10-hidroxi-5h-dibenz [b,f] azepin-5- carboxamida, y mezclas opticamente enriquecidas de las mismas | |
| HUP0104010A2 (hu) | Eljárás 2-hidroxi-propionsavak racemát reszolválására | |
| US20030092773A1 (en) | Process for the separation of the cis trans diasteroisomers of tramadol | |
| AR030938A1 (es) | Proceso de obtencion de los enantiomeros de la cetamina racemica; proceso de obtencion de sales farmaceuticamente aceptables de enantiomeros de la cetamina racemica y utilizacion de las sales farmaceuticamente aceptables obtenidas por el referido proceso | |
| DE3870821D1 (de) | Verfahren zur herstellung von vitamin a. | |
| Arita et al. | Resolution of 1‐and 2‐naphthylmethoxyacetic acids, NMR reagents for absolute configuration determination, by use of l‐phenylalaninol | |
| DK111583D0 (da) | Fremgangsmade til optisk oploesning af en blanding af enantiomererne af trans-3-((4-methoxyphenoxy)-methyl)-1-methyl-4-phenylpiperidin | |
| ATE383325T1 (de) | Verfahren zur herstellung von optisch aktivem alkohol in gegenwart von rhodium, einem chiralen ferrocenyldiphosphin und einem optisch aktivem diamin | |
| DE69819479D1 (de) | Verfahren zur herstellung eines enantiomers von narwedin | |
| SE8605457D0 (sv) | Optically active 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12h-dibenzo(d g)(1,3,6)dioxazocines and a process for the preparation thereof | |
| JP2009023978A (ja) | トランス−２−ベンジロキシシクロヘキシルアミンの製造法 | |
| DK0530657T3 (da) | Fremgangsmåde til enantiomeradskillelse af 5-hetaryl-1,3,4-thiadiazinon | |
| DE60239060D1 (de) | Neues trennmittel zur trennung eines optischen isomers und herstellungsverfahren dafür | |
| CN213701710U (zh) | 一种机械加工便于卸料的模架 | |
| WO1991007366A1 (en) | A process for preparing r(+)-terodiline and salts thereof | |
| BR102016008703A2 (pt) | Development of a biocatalytic process for the production of the rasagiline mesilate drug | |
| HUT46649A (en) | Chemical process for producing enantiomers of cis- or trans-cyclopropanecarboxylic acid esters | |
| ES2237234A1 (es) | Preparacion de (+) y (-)-trans-ciclopentano-1,2-diamina. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 110 | Patent granted |
Effective date: 20080415 |
|
| VENC | Patent expired |
Effective date: 20170110 |