ES2147341T3 - Procedimiento de preparacion de enantiomeros de o-desmetil-tramadol. - Google Patents
Procedimiento de preparacion de enantiomeros de o-desmetil-tramadol.Info
- Publication number
- ES2147341T3 ES2147341T3 ES96120727T ES96120727T ES2147341T3 ES 2147341 T3 ES2147341 T3 ES 2147341T3 ES 96120727 T ES96120727 T ES 96120727T ES 96120727 T ES96120727 T ES 96120727T ES 2147341 T3 ES2147341 T3 ES 2147341T3
- Authority
- ES
- Spain
- Prior art keywords
- desmetil
- preparation procedure
- enantiomer preparation
- tramadol enantiomer
- tramadol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- 230000000202 analgesic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19601744A DE19601744C2 (de) | 1996-01-19 | 1996-01-19 | Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2147341T3 true ES2147341T3 (es) | 2000-09-01 |
Family
ID=7783111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96120727T Expired - Lifetime ES2147341T3 (es) | 1996-01-19 | 1996-12-21 | Procedimiento de preparacion de enantiomeros de o-desmetil-tramadol. |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US5728885A (enExample) |
| EP (1) | EP0786450B1 (enExample) |
| JP (1) | JPH09216857A (enExample) |
| KR (1) | KR100507396B1 (enExample) |
| CN (1) | CN1073085C (enExample) |
| AR (1) | AR005390A1 (enExample) |
| AT (1) | ATE191454T1 (enExample) |
| AU (1) | AU705195B2 (enExample) |
| BR (1) | BR9700079A (enExample) |
| CA (1) | CA2195372C (enExample) |
| CO (1) | CO4520186A1 (enExample) |
| CZ (1) | CZ292427B6 (enExample) |
| DE (2) | DE19601744C2 (enExample) |
| DK (1) | DK0786450T3 (enExample) |
| ES (1) | ES2147341T3 (enExample) |
| GR (1) | GR3033390T3 (enExample) |
| HU (1) | HU223661B1 (enExample) |
| IL (1) | IL120029A (enExample) |
| IN (1) | IN181540B (enExample) |
| MY (1) | MY116593A (enExample) |
| NO (1) | NO306943B1 (enExample) |
| NZ (1) | NZ299998A (enExample) |
| PE (1) | PE29998A1 (enExample) |
| PL (1) | PL187373B1 (enExample) |
| PT (1) | PT786450E (enExample) |
| RU (1) | RU2185371C2 (enExample) |
| SI (1) | SI0786450T1 (enExample) |
| SK (1) | SK282629B6 (enExample) |
| UA (1) | UA45342C2 (enExample) |
| UY (1) | UY24438A1 (enExample) |
| ZA (1) | ZA97367B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19712398A1 (de) * | 1997-03-25 | 1998-10-01 | Gruenenthal Gmbh | Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel |
| PE20010623A1 (es) | 1999-10-05 | 2001-07-07 | Gruenenthal Chemie | Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria |
| EP1313460A2 (en) * | 1999-11-09 | 2003-05-28 | Darwin Discovery Limited | Therapeutic use and formulation of (-)-tramadol |
| DE10049483A1 (de) | 2000-09-29 | 2002-05-02 | Gruenenthal Gmbh | Substituierte 1-Aminobutan-3-ol-Derivate |
| DE10108123A1 (de) * | 2001-02-21 | 2002-10-02 | Gruenenthal Gmbh | Wirkstoffkombination |
| DE10108122A1 (de) | 2001-02-21 | 2002-10-02 | Gruenenthal Gmbh | Arzneimittel auf Basis von Tramadol |
| DE10109763A1 (de) * | 2001-02-28 | 2002-09-05 | Gruenenthal Gmbh | Pharmazeutische Salze |
| US20050176790A1 (en) | 2001-02-28 | 2005-08-11 | Johannes Bartholomaus | Pharmaceutical salts |
| CA2758923A1 (en) * | 2001-03-16 | 2002-09-26 | Dmi Biosciences, Inc. | Use of tramadol to delay ejaculation |
| US6649783B2 (en) | 2001-10-03 | 2003-11-18 | Euro-Celtique, S.A. | Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols |
| US6780891B2 (en) | 2001-11-30 | 2004-08-24 | Sepracor Inc. | Tramadol analogs and uses thereof |
| US20040248979A1 (en) * | 2003-06-03 | 2004-12-09 | Dynogen Pharmaceuticals, Inc. | Method of treating lower urinary tract disorders |
| DE102005033732B4 (de) * | 2005-05-27 | 2014-02-13 | Grünenthal GmbH | Trennung stereoisomerer N,N-Dialkylamino-2-alkyl-3-hydroxy-3-phenyl-alkane |
| EP1785412A1 (en) * | 2005-11-14 | 2007-05-16 | IPCA Laboratories Limited | Tramadol recovery process |
| KR20130122023A (ko) | 2007-02-12 | 2013-11-06 | 디엠아이 바이오사이언시스 인코포레이티드 | 트라마돌의 부작용을 감소시키는 방법 |
| SG174079A1 (en) * | 2007-02-12 | 2011-09-29 | Dmi Biosciences Inc | Treatment of comorbid premature ejaculation and erectile dysfunction |
| US20110251286A1 (en) * | 2010-03-10 | 2011-10-13 | Gruenenthal Gmbh | Crystalline salts and/or co-crystals of O-desmethyltramadol |
| EP2383255A1 (en) | 2010-04-28 | 2011-11-02 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
| EP2530072A1 (en) | 2011-06-03 | 2012-12-05 | Lacer, S.A. | New compounds, synthesis and use thereof in the treatment of pain |
| US10702485B2 (en) | 2011-07-09 | 2020-07-07 | Syntrix Biosystems Inc. | Compositions and methods for overcoming resistance to tramadol |
| EP3684753A1 (en) | 2017-09-18 | 2020-07-29 | R L Fine Chem Private Limited | A process for preparation of o-desmethyltramadol and salts thereof |
| US11000488B2 (en) | 2019-03-22 | 2021-05-11 | Syntrix Biosystems Inc. | Treating pain using desmetramadol |
| CN118108610B (zh) * | 2024-04-30 | 2025-01-10 | 山东新华制药股份有限公司 | 盐酸去甲曲马多的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1518663A1 (de) * | 1965-08-02 | 1969-12-18 | Gruenenthal Chemie | Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung |
| US3652589A (en) * | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
| US3652289A (en) * | 1970-07-20 | 1972-03-28 | Eastman Kodak Co | Silver halide emulsions and elements comprising trimethine hemioxonal dyes |
| MY110317A (en) | 1991-09-06 | 1998-04-30 | Mcneilab Inc | Compositions comprising a tramadol material and any of codeine, oxycodone or hydrocodone, and their use. |
| ATE169498T1 (de) | 1991-09-06 | 1998-08-15 | Mcneilab Inc | Zusammensetzung, die eine tramadol-verbindung und acetaminophen enthält, und ihre verwendung |
| JPH06122686A (ja) * | 1992-10-12 | 1994-05-06 | Fujisawa Pharmaceut Co Ltd | ラセミ体の光学分割法 |
-
1996
- 1996-01-19 DE DE19601744A patent/DE19601744C2/de not_active Expired - Fee Related
- 1996-12-18 PE PE1996000931A patent/PE29998A1/es not_active Application Discontinuation
- 1996-12-21 AT AT96120727T patent/ATE191454T1/de active
- 1996-12-21 PT PT96120727T patent/PT786450E/pt unknown
- 1996-12-21 EP EP96120727A patent/EP0786450B1/de not_active Expired - Lifetime
- 1996-12-21 DE DE59604885T patent/DE59604885D1/de not_active Expired - Lifetime
- 1996-12-21 DK DK96120727T patent/DK0786450T3/da active
- 1996-12-21 ES ES96120727T patent/ES2147341T3/es not_active Expired - Lifetime
- 1996-12-21 SI SI9630187T patent/SI0786450T1/xx unknown
- 1996-12-23 NZ NZ299998A patent/NZ299998A/en not_active IP Right Cessation
- 1996-12-30 CO CO96068522A patent/CO4520186A1/es unknown
- 1996-12-30 MY MYPI96005545A patent/MY116593A/en unknown
-
1997
- 1997-01-07 AR ARP970100068A patent/AR005390A1/es active IP Right Grant
- 1997-01-09 IN IN46CA1997 patent/IN181540B/en unknown
- 1997-01-10 UY UY24438A patent/UY24438A1/es not_active IP Right Cessation
- 1997-01-10 BR BR9700079A patent/BR9700079A/pt not_active Application Discontinuation
- 1997-01-16 ZA ZA97367A patent/ZA97367B/xx unknown
- 1997-01-16 HU HU9700140A patent/HU223661B1/hu not_active IP Right Cessation
- 1997-01-17 JP JP9006904A patent/JPH09216857A/ja not_active Ceased
- 1997-01-17 US US08/784,078 patent/US5728885A/en not_active Expired - Lifetime
- 1997-01-17 RU RU97100984/04A patent/RU2185371C2/ru not_active IP Right Cessation
- 1997-01-17 CZ CZ1997157A patent/CZ292427B6/cs not_active IP Right Cessation
- 1997-01-17 KR KR1019970001204A patent/KR100507396B1/ko not_active Expired - Fee Related
- 1997-01-17 PL PL97318002A patent/PL187373B1/pl not_active IP Right Cessation
- 1997-01-17 CA CA002195372A patent/CA2195372C/en not_active Expired - Fee Related
- 1997-01-17 NO NO970212A patent/NO306943B1/no not_active IP Right Cessation
- 1997-01-17 IL IL12002997A patent/IL120029A/xx not_active IP Right Cessation
- 1997-01-17 SK SK67-97A patent/SK282629B6/sk not_active IP Right Cessation
- 1997-01-17 UA UA97010174A patent/UA45342C2/uk unknown
- 1997-01-17 CN CN97102072A patent/CN1073085C/zh not_active Expired - Fee Related
- 1997-01-17 AU AU12216/97A patent/AU705195B2/en not_active Ceased
-
2000
- 2000-05-09 GR GR20000401077T patent/GR3033390T3/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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