AR005390A1 - Procedimiento de preparacion de enantiomeros de o-demetiltramadol - Google Patents

Procedimiento de preparacion de enantiomeros de o-demetiltramadol

Info

Publication number
AR005390A1
AR005390A1 ARP970100068A ARP970100068A AR005390A1 AR 005390 A1 AR005390 A1 AR 005390A1 AR P970100068 A ARP970100068 A AR P970100068A AR P970100068 A ARP970100068 A AR P970100068A AR 005390 A1 AR005390 A1 AR 005390A1
Authority
AR
Argentina
Prior art keywords
demethyltramadol
enantiomers
tramadol
procedure
preparation
Prior art date
Application number
ARP970100068A
Other languages
English (en)
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of AR005390A1 publication Critical patent/AR005390A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Procedimiento de preparación de los enantiómeros de O-demetiltramadol, de fórmula (I) en que una sal racémica de tramadol se convierte en su base;mediante ácido L-(+)-tartárico se precipita el anantiómero (-) del tramadol, se deja en libertad laba se y se convierte en el enantiómero (-) i O-demetiltramadol mediante hidruro de di-isobutil-aluminio; de las aguas madres de la precipitación con ácido tartárico se prepara el enantiómero (+) deO-demetiltramadol dejando la base de tramadol enliber tad y haciendo reaccionar con hidruro de di-isobutil-aluminio. Los enantiómeros de O-demetiltramadoltienen aplicación como analgésicos.
ARP970100068A 1996-01-19 1997-01-07 Procedimiento de preparacion de enantiomeros de o-demetiltramadol AR005390A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19601744A DE19601744C2 (de) 1996-01-19 1996-01-19 Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol

Publications (1)

Publication Number Publication Date
AR005390A1 true AR005390A1 (es) 1999-04-28

Family

ID=7783111

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970100068A AR005390A1 (es) 1996-01-19 1997-01-07 Procedimiento de preparacion de enantiomeros de o-demetiltramadol

Country Status (32)

Country Link
US (1) US5728885A (es)
EP (1) EP0786450B1 (es)
JP (1) JPH09216857A (es)
KR (1) KR100507396B1 (es)
CN (1) CN1073085C (es)
AR (1) AR005390A1 (es)
AT (1) ATE191454T1 (es)
AU (1) AU705195B2 (es)
BR (1) BR9700079A (es)
CA (1) CA2195372C (es)
CO (1) CO4520186A1 (es)
CZ (1) CZ292427B6 (es)
DE (2) DE19601744C2 (es)
DK (1) DK0786450T3 (es)
ES (1) ES2147341T3 (es)
GR (1) GR3033390T3 (es)
HK (1) HK1004810A1 (es)
HU (1) HU223661B1 (es)
IL (1) IL120029A (es)
IN (1) IN181540B (es)
MY (1) MY116593A (es)
NO (1) NO306943B1 (es)
NZ (1) NZ299998A (es)
PE (1) PE29998A1 (es)
PL (1) PL187373B1 (es)
PT (1) PT786450E (es)
RU (1) RU2185371C2 (es)
SI (1) SI0786450T1 (es)
SK (1) SK282629B6 (es)
UA (1) UA45342C2 (es)
UY (1) UY24438A1 (es)
ZA (1) ZA97367B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19712398A1 (de) * 1997-03-25 1998-10-01 Gruenenthal Gmbh Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel
PE20010623A1 (es) 1999-10-05 2001-07-07 Gruenenthal Chemie Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
WO2001034125A2 (en) * 1999-11-09 2001-05-17 Darwin Discovery Limited Therapeutic use and formulation of (-)-tramadol
DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
DE10108122A1 (de) 2001-02-21 2002-10-02 Gruenenthal Gmbh Arzneimittel auf Basis von Tramadol
DE10108123A1 (de) * 2001-02-21 2002-10-02 Gruenenthal Gmbh Wirkstoffkombination
US20050176790A1 (en) 2001-02-28 2005-08-11 Johannes Bartholomaus Pharmaceutical salts
DE10109763A1 (de) * 2001-02-28 2002-09-05 Gruenenthal Gmbh Pharmazeutische Salze
WO2002074241A2 (en) * 2001-03-16 2002-09-26 Dmi Biosciences Inc. Method of delaying ejaculation
US6649783B2 (en) 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
AU2002364517A1 (en) 2001-11-30 2003-06-17 Sepracor Inc. Tramadol analogs and uses thereof
US20040248979A1 (en) * 2003-06-03 2004-12-09 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
DE102005033732B4 (de) 2005-05-27 2014-02-13 Grünenthal GmbH Trennung stereoisomerer N,N-Dialkylamino-2-alkyl-3-hydroxy-3-phenyl-alkane
EP1785412A1 (en) * 2005-11-14 2007-05-16 IPCA Laboratories Limited Tramadol recovery process
KR20130122023A (ko) 2007-02-12 2013-11-06 디엠아이 바이오사이언시스 인코포레이티드 트라마돌의 부작용을 감소시키는 방법
NZ579169A (en) * 2007-02-12 2012-05-25 Dmi Biosciences Inc Treatment of comorbid premature ejaculation and erectile dysfunction using tramadol and a phosphodiesterase (pde) inhibitor
WO2011110595A1 (de) * 2010-03-10 2011-09-15 Grünenthal GmbH Kristalline salze und/oder cokristalle von o-desmethyltramadol
EP2383255A1 (en) 2010-04-28 2011-11-02 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
EP2530072A1 (en) 2011-06-03 2012-12-05 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
US10781163B2 (en) 2017-09-18 2020-09-22 R L Finechem Private Limited Process for preparation of O-Desmethyltramadol and salts thereof
US11000488B2 (en) 2019-03-22 2021-05-11 Syntrix Biosystems Inc. Treating pain using desmetramadol

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1518663A1 (de) * 1965-08-02 1969-12-18 Gruenenthal Chemie Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
DE69215316T2 (de) * 1991-09-06 1997-03-20 Mcneilab Inc Zusammensetzungen, die Tramadol und irgendein Kodein, Oxykoden oder Hydrokoden enthalten, und deren Verwendung
AU651247B2 (en) 1991-09-06 1994-07-14 Mcneilab, Inc. Composition comprising a tramadol material and acetaminophen and its use
JPH06122686A (ja) * 1992-10-12 1994-05-06 Fujisawa Pharmaceut Co Ltd ラセミ体の光学分割法

Also Published As

Publication number Publication date
MX9700523A (es) 1997-07-31
HU9700140D0 (en) 1997-03-28
SK6797A3 (en) 1997-08-06
KR100507396B1 (ko) 2005-12-20
DK0786450T3 (da) 2000-07-10
CN1167107A (zh) 1997-12-10
AU705195B2 (en) 1999-05-20
HUP9700140A2 (hu) 1998-01-28
EP0786450A2 (de) 1997-07-30
GR3033390T3 (en) 2000-09-29
PT786450E (pt) 2000-08-31
NO970212D0 (no) 1997-01-17
AU1221697A (en) 1997-07-24
HU223661B1 (hu) 2004-11-29
KR970059161A (ko) 1997-08-12
DE19601744C2 (de) 1998-04-16
RU2185371C2 (ru) 2002-07-20
HK1004810A1 (en) 1998-12-11
SI0786450T1 (en) 2000-08-31
ATE191454T1 (de) 2000-04-15
ES2147341T3 (es) 2000-09-01
CA2195372A1 (en) 1997-07-20
BR9700079A (pt) 1998-11-10
CA2195372C (en) 2005-08-30
MY116593A (en) 2004-02-28
DE59604885D1 (de) 2000-05-11
US5728885A (en) 1998-03-17
PL318002A1 (en) 1997-07-21
NO970212L (no) 1997-07-21
DE19601744A1 (de) 1997-07-31
CZ292427B6 (cs) 2003-09-17
CO4520186A1 (es) 1997-10-15
UY24438A1 (es) 1997-01-10
CN1073085C (zh) 2001-10-17
NO306943B1 (no) 2000-01-17
SK282629B6 (sk) 2002-10-08
IL120029A (en) 2000-01-31
IL120029A0 (en) 1997-04-15
EP0786450A3 (de) 1997-10-15
IN181540B (es) 1998-07-11
CZ15797A3 (cs) 1998-05-13
NZ299998A (en) 1998-01-26
JPH09216857A (ja) 1997-08-19
EP0786450B1 (de) 2000-04-05
ZA97367B (en) 1997-07-17
HUP9700140A3 (en) 2000-03-28
UA45342C2 (uk) 2002-04-15
PE29998A1 (es) 1998-08-08
PL187373B1 (pl) 2004-06-30

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