ES2200699A1 - Procedimiento para la separacion de r(-)- y s(+)-5-(2-((2-(2-etoxifenoxi)etil)amino)propil-2-metoxibenceno-sulfonamida. - Google Patents
Procedimiento para la separacion de r(-)- y s(+)-5-(2-((2-(2-etoxifenoxi)etil)amino)propil-2-metoxibenceno-sulfonamida.Info
- Publication number
- ES2200699A1 ES2200699A1 ES200201638A ES200201638A ES2200699A1 ES 2200699 A1 ES2200699 A1 ES 2200699A1 ES 200201638 A ES200201638 A ES 200201638A ES 200201638 A ES200201638 A ES 200201638A ES 2200699 A1 ES2200699 A1 ES 2200699A1
- Authority
- ES
- Spain
- Prior art keywords
- ethoxyphenoxy
- separating
- enantiomers
- methoxybenzene
- sulphonamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/42—Separation; Purification; Stabilisation; Use of additives
- C07C303/44—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/19—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/47—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Procedimiento para la separación de R(-)- y S(+)-5-[2-[[2-(2- etoxifenoxi)etil]amino)propil-2-metoxibenceno-sulfonamida. El procedimiento para separarlos enantiómeros R(-)- y S(+)-5-(2-((2- etoxifenoxi)etil)-amino)propil-2-metoxibencenosulfonamida comprende (a) hacer reaccionar una mezcla de dichos enantiómeros con un ácido orgánico ópticamente activo para formar sales diastereoisómeras con dichos enantiómeros, en donde dichas sales diastereoisómeras tienen distinta solubilidad y pueden ser separadas por cristalización; (b) separar la mezcla de sales diastereoisómeras enriquecida en la sal de uno de los enantiómeros; y (c) liberar dichas sales para obtener el enantiómero R(-)- o S(+)-. El enantiómero R(-)-5-(2-((2- etoxifenoxi)etil)-amino)propil-2-metoxibencenosulfonamida tiene actividad a-bloqueante adrenérgica y es útil como agente antihipertensor adecuado para el tratamiento de la insuficiencia cardiaca congestiva y la hipertrofia prostática benigna.
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200201638A ES2200699B1 (es) | 2002-07-12 | 2002-07-12 | Procedimiento para la separacion de r(-) y s(+)-5-(2-((2-(etoxifenoxi)etil)amino)propil-2-metoxibenceno-sulfonamida. |
JP2004520689A JP2005533094A (ja) | 2002-07-12 | 2003-07-11 | R(−)−およびs(+)−5−[2−[[2−(2−エトキシフェノキシ)エチル]アミノ]プロピル]−2−メトキシベンゼンスルホンアミドの分離方法 |
CA002492270A CA2492270A1 (en) | 2002-07-12 | 2003-07-11 | Method of separating r(-)- and s(+)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl-2-methoxybenzene-sulphonamide |
PCT/ES2003/000357 WO2004006829A2 (es) | 2002-07-12 | 2003-07-11 | Procedimiento para la separación de r(-)- y s(+)-5-[2-[[2-(2-etoxifenoxi)etil]amino]propil-2-metoxibenceno-sulfonamida |
EP03740513A EP1522538A2 (en) | 2002-07-12 | 2003-07-11 | Method of separating r(-)- and s(+)-5- 2- 2-(2-ethoxyphenoxy)ethyl]amino]propyl-2-methoxybenzene-sulphonamide |
AU2003281155A AU2003281155A1 (en) | 2002-07-12 | 2003-07-11 | Method of separating r(-)- and s(+)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl-2-methoxybenzene-sulphonamide |
US10/799,909 US7105698B2 (en) | 2002-07-12 | 2004-03-12 | Process for the separation of R(-)-and S(+)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2- methoxybenzenesulfonamide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200201638A ES2200699B1 (es) | 2002-07-12 | 2002-07-12 | Procedimiento para la separacion de r(-) y s(+)-5-(2-((2-(etoxifenoxi)etil)amino)propil-2-metoxibenceno-sulfonamida. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2200699A1 true ES2200699A1 (es) | 2004-03-01 |
ES2200699B1 ES2200699B1 (es) | 2005-10-01 |
Family
ID=30011364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200201638A Expired - Fee Related ES2200699B1 (es) | 2002-07-12 | 2002-07-12 | Procedimiento para la separacion de r(-) y s(+)-5-(2-((2-(etoxifenoxi)etil)amino)propil-2-metoxibenceno-sulfonamida. |
Country Status (7)
Country | Link |
---|---|
US (1) | US7105698B2 (es) |
EP (1) | EP1522538A2 (es) |
JP (1) | JP2005533094A (es) |
AU (1) | AU2003281155A1 (es) |
CA (1) | CA2492270A1 (es) |
ES (1) | ES2200699B1 (es) |
WO (1) | WO2004006829A2 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT103216B (pt) | 2004-12-06 | 2010-05-19 | Hovione Farmaciencia S A | Preparação de tamsulosin |
EP2161998B1 (en) * | 2007-06-04 | 2015-09-02 | Intra-Cellular Therapies, Inc. | Pyridine derivatives as NET/SERT modulators |
WO2010043571A1 (en) | 2008-10-13 | 2010-04-22 | Interquim, S.A. | Process for the preparation of optically active (s)-(-)-2-(n-propylamino)-5-methoxytetraline and (s)-(-)-2-(n-propylamino)-5-hydroxytetraline compounds |
WO2012110092A1 (en) * | 2011-02-17 | 2012-08-23 | Synthon Bv | Tamsulosin derivatives |
US8792630B2 (en) * | 2012-09-24 | 2014-07-29 | Satmap International Holdings Limited | Use of abstracted data in pattern matching system |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2000382A6 (es) * | 1985-11-13 | 1988-02-16 | Yamanouchi Pharma Co Ltd | Un procedimiento para la produccion de derivados de fenetilamina substituidos |
ES2029838T3 (es) * | 1986-07-21 | 1992-10-01 | Yamanouchi Pharmaceutical Co. Ltd. | Un procedimiento para producir un derivado de bencenosulfonamida opticamente activo. |
US5447958A (en) * | 1980-02-08 | 1995-09-05 | Yamanouchi Pharmaceutical Co., Ltd. | Sulfamoyl-substituted phenethylamine derivatives, their preparation, and pharmaceutical compositions, containing them |
WO2003037850A1 (en) * | 2001-10-31 | 2003-05-08 | Synthon B.V. | Process for resolution of tamsulosin |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56110665A (en) * | 1980-02-08 | 1981-09-01 | Yamanouchi Pharmaceut Co Ltd | Sulfamoyl-substituted phenetylamine derivative and its preparation |
JPS57136561A (en) * | 1981-02-17 | 1982-08-23 | Yamanouchi Pharmaceut Co Ltd | Benzenesulfonamide derivative |
JP2696363B2 (ja) * | 1988-02-19 | 1998-01-14 | 北陸製薬株式会社 | フェノキシエチルアミン誘導体 |
CN1261411C (zh) | 2001-10-31 | 2006-06-28 | Dsmip资产有限公司 | 类视色素的制备 |
-
2002
- 2002-07-12 ES ES200201638A patent/ES2200699B1/es not_active Expired - Fee Related
-
2003
- 2003-07-11 JP JP2004520689A patent/JP2005533094A/ja active Pending
- 2003-07-11 WO PCT/ES2003/000357 patent/WO2004006829A2/es active Application Filing
- 2003-07-11 CA CA002492270A patent/CA2492270A1/en not_active Abandoned
- 2003-07-11 EP EP03740513A patent/EP1522538A2/en not_active Withdrawn
- 2003-07-11 AU AU2003281155A patent/AU2003281155A1/en not_active Abandoned
-
2004
- 2004-03-12 US US10/799,909 patent/US7105698B2/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5447958A (en) * | 1980-02-08 | 1995-09-05 | Yamanouchi Pharmaceutical Co., Ltd. | Sulfamoyl-substituted phenethylamine derivatives, their preparation, and pharmaceutical compositions, containing them |
ES2000382A6 (es) * | 1985-11-13 | 1988-02-16 | Yamanouchi Pharma Co Ltd | Un procedimiento para la produccion de derivados de fenetilamina substituidos |
ES2029838T3 (es) * | 1986-07-21 | 1992-10-01 | Yamanouchi Pharmaceutical Co. Ltd. | Un procedimiento para producir un derivado de bencenosulfonamida opticamente activo. |
WO2003037850A1 (en) * | 2001-10-31 | 2003-05-08 | Synthon B.V. | Process for resolution of tamsulosin |
Also Published As
Publication number | Publication date |
---|---|
AU2003281155A1 (en) | 2004-02-02 |
US20050004398A1 (en) | 2005-01-06 |
JP2005533094A (ja) | 2005-11-04 |
EP1522538A2 (en) | 2005-04-13 |
WO2004006829A2 (es) | 2004-01-22 |
WO2004006829A3 (es) | 2004-04-08 |
AU2003281155A8 (en) | 2004-02-02 |
US7105698B2 (en) | 2006-09-12 |
ES2200699B1 (es) | 2005-10-01 |
CA2492270A1 (en) | 2004-01-22 |
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Legal Events
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