ATE509619T1 - Herstellungsverfahren für eine feste dispersion mit itraconazol - Google Patents
Herstellungsverfahren für eine feste dispersion mit itraconazolInfo
- Publication number
- ATE509619T1 ATE509619T1 AT05765021T AT05765021T ATE509619T1 AT E509619 T1 ATE509619 T1 AT E509619T1 AT 05765021 T AT05765021 T AT 05765021T AT 05765021 T AT05765021 T AT 05765021T AT E509619 T1 ATE509619 T1 AT E509619T1
- Authority
- AT
- Austria
- Prior art keywords
- itraconazole
- solid dispersion
- present
- containing solid
- preparing
- Prior art date
Links
- 229960004130 itraconazole Drugs 0.000 title abstract 8
- 239000007962 solid dispersion Substances 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- VHVPQPYKVGDNFY-ZPGVKDDISA-N itraconazole Chemical compound O=C1N(C(C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-ZPGVKDDISA-N 0.000 title 1
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 abstract 7
- 238000000034 method Methods 0.000 abstract 5
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 235000014655 lactic acid Nutrition 0.000 abstract 1
- 239000004310 lactic acid Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20040047369 | 2004-06-24 | ||
| PCT/KR2005/001991 WO2006001669A1 (en) | 2004-06-24 | 2005-06-24 | Manufacturing method of solid dispersion containing itraconazole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE509619T1 true ATE509619T1 (de) | 2011-06-15 |
Family
ID=35782042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05765021T ATE509619T1 (de) | 2004-06-24 | 2005-06-24 | Herstellungsverfahren für eine feste dispersion mit itraconazol |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9492446B2 (de) |
| EP (1) | EP1765350B1 (de) |
| KR (1) | KR100663079B1 (de) |
| CN (1) | CN1997372B (de) |
| AT (1) | ATE509619T1 (de) |
| WO (1) | WO2006001669A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007308480A (ja) * | 2006-04-20 | 2007-11-29 | Shin Etsu Chem Co Ltd | 腸溶性固体分散体を含んでなる固形製剤 |
| US10004682B2 (en) | 2010-08-24 | 2018-06-26 | Rutgers, The State University Of New Jersey | Formulation and manufacture of pharmaceuticals by impregnation onto porous carriers |
| WO2012039768A2 (en) * | 2010-09-24 | 2012-03-29 | Texas Southern University | Itraconazole formulations |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1263831B (it) * | 1993-01-29 | 1996-09-04 | Paolo Chiesi | Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo basico, un acido ed una ciclodestrina |
| US5883097A (en) * | 1998-04-16 | 1999-03-16 | Schering Corporation | Soluble azole antifungal salt |
| KR100331529B1 (ko) * | 1999-06-16 | 2002-04-06 | 민경윤 | 난용성 항진균제의 경구투여용 조성물 및 그의 제조 방법 |
| CA2291346A1 (en) * | 1999-11-26 | 2001-05-26 | Bernard Charles Sherman | Antifungal solutions |
| KR100394075B1 (ko) | 2000-04-22 | 2003-08-06 | 한국화학연구원 | 생체이용율이 증진된 경구용 이트라코나졸 제제 |
| GB0015239D0 (en) | 2000-06-21 | 2000-08-16 | Biochemie Gmbh | Organic compounds |
| AU2003224794A1 (en) * | 2002-03-29 | 2003-10-13 | Alza Corporation | Volume efficient controlled release dosage form |
| JP2005538973A (ja) | 2002-07-04 | 2005-12-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 異なる２種類のポリマーマトリックスを含んで成る固体分散体 |
-
2005
- 2005-06-24 EP EP05765021A patent/EP1765350B1/de not_active Not-in-force
- 2005-06-24 KR KR1020050055120A patent/KR100663079B1/ko active IP Right Grant
- 2005-06-24 CN CN2005800208259A patent/CN1997372B/zh not_active Expired - Fee Related
- 2005-06-24 AT AT05765021T patent/ATE509619T1/de not_active IP Right Cessation
- 2005-06-24 WO PCT/KR2005/001991 patent/WO2006001669A1/en active Application Filing
- 2005-06-24 US US11/630,781 patent/US9492446B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20090298847A1 (en) | 2009-12-03 |
| EP1765350B1 (de) | 2011-05-18 |
| CN1997372B (zh) | 2010-06-02 |
| CN1997372A (zh) | 2007-07-11 |
| US9492446B2 (en) | 2016-11-15 |
| EP1765350A4 (de) | 2009-09-09 |
| WO2006001669A1 (en) | 2006-01-05 |
| EP1765350A1 (de) | 2007-03-28 |
| KR20060046529A (ko) | 2006-05-17 |
| KR100663079B1 (ko) | 2007-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |