CO4520186A1 - Procedimiento de preparacion de enantiomeros de o-demetiltramadol - Google Patents

Procedimiento de preparacion de enantiomeros de o-demetiltramadol

Info

Publication number
CO4520186A1
CO4520186A1 CO96068522A CO96068522A CO4520186A1 CO 4520186 A1 CO4520186 A1 CO 4520186A1 CO 96068522 A CO96068522 A CO 96068522A CO 96068522 A CO96068522 A CO 96068522A CO 4520186 A1 CO4520186 A1 CO 4520186A1
Authority
CO
Colombia
Prior art keywords
base
demethyltramadol
enantiomer
salt
enantiomers
Prior art date
Application number
CO96068522A
Other languages
English (en)
Inventor
Helmut Buschmann
Werner Winter
Graudums Ivars
Peter Jansen
Werner Alfred Wolfgang
Josef Friderichs Elmar
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of CO4520186A1 publication Critical patent/CO4520186A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE ENANTIOMEROS DE 0- DEMETILTRAMADOL, CARACTERIZADO PORQUE UNA SAL RA- CEMICA DE TRAMADOL SE CONVIERTE EN SU BASE; ME- DIANTE ACIDO L-(+)-TARTARICO SE PRECIPITA EL ENAN- TIOMERO (-) DEL TRAMADOL, SE DEJA EN LIBERTAD LA BASE Y SE CONVIERTE EN EL ENANTIOMERO (-) DE 0-DE- METILTRAMADOL MEDIANTE HIDRURO DE DI-ISOBUTIL-ALU- MINIO; DE LAS AGUAS MADRES DE LA PRECIPITACION CON ACIDO TARTARICO SE PREPARA EL ENANTIOMERO (+) DE 0-DEMETILTRAMADOL DEJANDO LA BASE DE TRAMADOL EN LIBERTAD Y HACIENDO REACCIONAR CON HIDRURO DE DI-ISOBUTIL-ALUMINIO. APLICACION DE 0-DEMETILTRAMADOL PREPARADO SEGUN LAS REIVINDICACIONES 1 A 6, CARACTERIZADA PORQUE COMO BASE Y/O SAL EN FORMA DE UN RACEMATO O UN E- NANTIOMERO POR SI SOLO O EN COMBINACION CON TRAMA- DOL COMO BASE Y/O SAL EN FORMA DE UN RACEMATO O UN ENANTIOMERO, SE APLICA COMO ANALGESICO EN UN MEDI- CAMENTO.
CO96068522A 1996-01-19 1996-12-30 Procedimiento de preparacion de enantiomeros de o-demetiltramadol CO4520186A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19601744A DE19601744C2 (de) 1996-01-19 1996-01-19 Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol

Publications (1)

Publication Number Publication Date
CO4520186A1 true CO4520186A1 (es) 1997-10-15

Family

ID=7783111

Family Applications (1)

Application Number Title Priority Date Filing Date
CO96068522A CO4520186A1 (es) 1996-01-19 1996-12-30 Procedimiento de preparacion de enantiomeros de o-demetiltramadol

Country Status (32)

Country Link
US (1) US5728885A (es)
EP (1) EP0786450B1 (es)
JP (1) JPH09216857A (es)
KR (1) KR100507396B1 (es)
CN (1) CN1073085C (es)
AR (1) AR005390A1 (es)
AT (1) ATE191454T1 (es)
AU (1) AU705195B2 (es)
BR (1) BR9700079A (es)
CA (1) CA2195372C (es)
CO (1) CO4520186A1 (es)
CZ (1) CZ292427B6 (es)
DE (2) DE19601744C2 (es)
DK (1) DK0786450T3 (es)
ES (1) ES2147341T3 (es)
GR (1) GR3033390T3 (es)
HK (1) HK1004810A1 (es)
HU (1) HU223661B1 (es)
IL (1) IL120029A (es)
IN (1) IN181540B (es)
MY (1) MY116593A (es)
NO (1) NO306943B1 (es)
NZ (1) NZ299998A (es)
PE (1) PE29998A1 (es)
PL (1) PL187373B1 (es)
PT (1) PT786450E (es)
RU (1) RU2185371C2 (es)
SI (1) SI0786450T1 (es)
SK (1) SK282629B6 (es)
UA (1) UA45342C2 (es)
UY (1) UY24438A1 (es)
ZA (1) ZA97367B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19712398A1 (de) * 1997-03-25 1998-10-01 Gruenenthal Gmbh Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel
PE20010623A1 (es) 1999-10-05 2001-07-07 Gruenenthal Chemie Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
EP1313460A2 (en) * 1999-11-09 2003-05-28 Darwin Discovery Limited Therapeutic use and formulation of (-)-tramadol
DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
DE10108123A1 (de) * 2001-02-21 2002-10-02 Gruenenthal Gmbh Wirkstoffkombination
DE10108122A1 (de) 2001-02-21 2002-10-02 Gruenenthal Gmbh Arzneimittel auf Basis von Tramadol
US20050176790A1 (en) 2001-02-28 2005-08-11 Johannes Bartholomaus Pharmaceutical salts
DE10109763A1 (de) * 2001-02-28 2002-09-05 Gruenenthal Gmbh Pharmazeutische Salze
PT1397126E (pt) 2001-03-16 2006-10-31 Dmi Biosciences Inc Utilizacao de tramadol para retardar a ejaculacao
US6649783B2 (en) * 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
WO2003048113A1 (en) 2001-11-30 2003-06-12 Sepracor Inc. Tramadol analogs and uses thereof
US20040248979A1 (en) * 2003-06-03 2004-12-09 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
DE102005033732B4 (de) 2005-05-27 2014-02-13 Grünenthal GmbH Trennung stereoisomerer N,N-Dialkylamino-2-alkyl-3-hydroxy-3-phenyl-alkane
EP1785412A1 (en) * 2005-11-14 2007-05-16 IPCA Laboratories Limited Tramadol recovery process
NZ579169A (en) 2007-02-12 2012-05-25 Dmi Biosciences Inc Treatment of comorbid premature ejaculation and erectile dysfunction using tramadol and a phosphodiesterase (pde) inhibitor
BRPI0807281A2 (pt) 2007-02-12 2014-04-29 Dmi Biosciences Inc Reduzindo os efeitos colaterais de tramadol
EP2545027A1 (de) * 2010-03-10 2013-01-16 Grünenthal GmbH Kristalline salze und/oder cokristalle von o-desmethyltramadol
EP2383255A1 (en) 2010-04-28 2011-11-02 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
EP2530072A1 (en) 2011-06-03 2012-12-05 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
US10781163B2 (en) 2017-09-18 2020-09-22 R L Finechem Private Limited Process for preparation of O-Desmethyltramadol and salts thereof
US11000488B2 (en) 2019-03-22 2021-05-11 Syntrix Biosystems Inc. Treating pain using desmetramadol

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1518663A1 (de) * 1965-08-02 1969-12-18 Gruenenthal Chemie Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
PH31112A (en) * 1991-09-06 1998-02-23 Mcneilab Inc Composition comprising a tramadol material and anyof codiene, oxycodone or hydrocodone and their use.
CA2095523C (en) 1991-09-06 2004-06-22 Robert B. Raffa Composition comprising a tramadol material and acetaminophen and its use
JPH06122686A (ja) * 1992-10-12 1994-05-06 Fujisawa Pharmaceut Co Ltd ラセミ体の光学分割法

Also Published As

Publication number Publication date
CN1167107A (zh) 1997-12-10
CN1073085C (zh) 2001-10-17
HU9700140D0 (en) 1997-03-28
RU2185371C2 (ru) 2002-07-20
IL120029A (en) 2000-01-31
PT786450E (pt) 2000-08-31
AU1221697A (en) 1997-07-24
SK282629B6 (sk) 2002-10-08
UA45342C2 (uk) 2002-04-15
IN181540B (es) 1998-07-11
BR9700079A (pt) 1998-11-10
DE19601744C2 (de) 1998-04-16
CA2195372C (en) 2005-08-30
ZA97367B (en) 1997-07-17
ATE191454T1 (de) 2000-04-15
HUP9700140A2 (hu) 1998-01-28
HK1004810A1 (en) 1998-12-11
DE19601744A1 (de) 1997-07-31
HU223661B1 (hu) 2004-11-29
KR970059161A (ko) 1997-08-12
EP0786450B1 (de) 2000-04-05
SI0786450T1 (en) 2000-08-31
CA2195372A1 (en) 1997-07-20
ES2147341T3 (es) 2000-09-01
MX9700523A (es) 1997-07-31
NO970212D0 (no) 1997-01-17
MY116593A (en) 2004-02-28
IL120029A0 (en) 1997-04-15
CZ15797A3 (cs) 1998-05-13
CZ292427B6 (cs) 2003-09-17
EP0786450A3 (de) 1997-10-15
SK6797A3 (en) 1997-08-06
PE29998A1 (es) 1998-08-08
UY24438A1 (es) 1997-01-10
NO306943B1 (no) 2000-01-17
DK0786450T3 (da) 2000-07-10
PL187373B1 (pl) 2004-06-30
PL318002A1 (en) 1997-07-21
HUP9700140A3 (en) 2000-03-28
AR005390A1 (es) 1999-04-28
DE59604885D1 (de) 2000-05-11
NZ299998A (en) 1998-01-26
NO970212L (no) 1997-07-21
US5728885A (en) 1998-03-17
GR3033390T3 (en) 2000-09-29
AU705195B2 (en) 1999-05-20
JPH09216857A (ja) 1997-08-19
EP0786450A2 (de) 1997-07-30
KR100507396B1 (ko) 2005-12-20

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