DE69529686D1 - Enantiosektive herstellung pharmazeutisch aktiver sulfoxide durch biooxidation - Google Patents

Enantiosektive herstellung pharmazeutisch aktiver sulfoxide durch biooxidation

Info

Publication number
DE69529686D1
DE69529686D1 DE69529686T DE69529686T DE69529686D1 DE 69529686 D1 DE69529686 D1 DE 69529686D1 DE 69529686 T DE69529686 T DE 69529686T DE 69529686 T DE69529686 T DE 69529686T DE 69529686 D1 DE69529686 D1 DE 69529686D1
Authority
DE
Germany
Prior art keywords
pct
pharmaceutically active
enantioseective
biooxidation
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69529686T
Other languages
English (en)
Other versions
DE69529686T2 (de
Inventor
Robert Holt
Per Lindberg
Christopher Reeve
Stephen Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE69529686D1 publication Critical patent/DE69529686D1/de
Publication of DE69529686T2 publication Critical patent/DE69529686T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69529686T 1994-11-28 1995-11-27 Enantiosektive herstellung pharmazeutisch aktiver sulfoxide durch biooxidation Expired - Fee Related DE69529686T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9423970A GB9423970D0 (en) 1994-11-28 1994-11-28 Oxidation
PCT/SE1995/001415 WO1996017076A1 (en) 1994-11-28 1995-11-27 Enantioselective preparation of pharmaceutically active sulfoxides by biooxidation

Publications (2)

Publication Number Publication Date
DE69529686D1 true DE69529686D1 (de) 2003-03-27
DE69529686T2 DE69529686T2 (de) 2004-01-15

Family

ID=10765078

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69529686T Expired - Fee Related DE69529686T2 (de) 1994-11-28 1995-11-27 Enantiosektive herstellung pharmazeutisch aktiver sulfoxide durch biooxidation

Country Status (11)

Country Link
US (1) US5840552A (de)
EP (1) EP0795024B1 (de)
JP (1) JP3684576B2 (de)
AT (1) ATE232907T1 (de)
AU (1) AU699577B2 (de)
CA (1) CA2203999A1 (de)
DE (1) DE69529686T2 (de)
DK (1) DK0795024T3 (de)
ES (1) ES2191066T3 (de)
GB (1) GB9423970D0 (de)
WO (1) WO1996017076A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE504459C2 (sv) * 1994-07-15 1997-02-17 Astra Ab Förfarande för framställning av substituerade sulfoxider
GB9423968D0 (en) * 1994-11-28 1995-01-11 Astra Ab Resolution
GB9423970D0 (en) * 1994-11-28 1995-01-11 Astra Ab Oxidation
SE510650C2 (sv) * 1997-05-30 1999-06-14 Astra Ab Ny förening
CN1268137A (zh) 1997-07-03 2000-09-27 杜邦药品公司 治疗神经失调的咪唑并嘧啶和咪唑并吡啶
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
SE9900274D0 (sv) 1999-01-28 1999-01-28 Astra Ab New compound
AU6727700A (en) * 1999-08-25 2001-03-19 Takeda Chemical Industries Ltd. Process for the preparation of optically active sulfoxide derivatives
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
CN1193024C (zh) * 2000-04-28 2005-03-16 武田药品工业株式会社 生产旋光的亚砜衍生物的方法
DE10254167A1 (de) 2002-11-20 2004-06-09 Icon Genetics Ag Verfahren zur Kontrolle von zellulären Prozessen in Pflanzen
PT1578742E (pt) 2002-12-06 2013-01-24 Nycomed Gmbh Processo para preparar compostos activos opticamente puros
CA2507889C (en) 2002-12-06 2012-02-07 Altana Pharma Ag Process for preparing (s)-pantoprazole
EP1801110A1 (de) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Argininsalz des Esomeprazols
MY148301A (en) 2006-07-05 2013-03-29 Lupin Ltd Process for the preparation of optically pure or optically enriched enantiomers of sulphoxide compounds
SI2510089T1 (sl) 2009-12-08 2015-12-31 Codexis, Inc. Sinteza prazolnih spojin
CZ2010790A3 (cs) * 2010-11-01 2011-08-03 Zentiva, K.S. Kmen mikroorganismu Bacillus sp. B71 CCM 7718
WO2012078800A2 (en) 2010-12-08 2012-06-14 Codexis, Inc. Biocatalysts and methods for the synthesis of armodafinil
CN108239618A (zh) * 2016-12-23 2018-07-03 浙江京新药业股份有限公司 共表达环己酮单加氧酶和异丙醇脱氢酶的基因工程菌及其应用
CN108251466B (zh) * 2016-12-28 2021-07-02 浙江京新药业股份有限公司 一种酶法合成埃索美拉唑的方法
CN107418923B (zh) 2017-09-20 2018-03-23 华东理工大学 伯克霍尔德菌及其应用
FR3097234B1 (fr) * 2019-06-17 2021-06-18 Arkema France Procede selectif de preparation de sulfoxydes par catalyse enzymatique
CN113461663B (zh) * 2020-03-30 2023-11-28 江苏奥赛康药业有限公司 一种质子泵抑制剂艾司奥美拉唑钠的膜分离纯化方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US5049674A (en) * 1989-12-20 1991-09-17 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
EP0593463B1 (de) * 1990-06-20 1999-09-15 Astra Aktiebolag Dialkoxypyridinylbenzimidazolderivate, verfahren zur herstellung und ihre pharmazeutische verwendung
DE4035455A1 (de) * 1990-11-08 1992-05-14 Byk Gulden Lomberg Chem Fab Enantiomerentrennung
TNSN95062A1 (fr) * 1994-05-27 1996-02-06 Astra Ab Nouveaux derives dialkoxy-pyridinyle-benzimidazole
TNSN95063A1 (fr) * 1994-05-27 1996-02-06 Astra Ab Nouveaux benzimidazoles substitues
GB9423970D0 (en) * 1994-11-28 1995-01-11 Astra Ab Oxidation

Also Published As

Publication number Publication date
WO1996017076A1 (en) 1996-06-06
DE69529686T2 (de) 2004-01-15
EP0795024B1 (de) 2003-02-19
ES2191066T3 (es) 2003-09-01
AU4126996A (en) 1996-06-19
EP0795024A1 (de) 1997-09-17
CA2203999A1 (en) 1996-06-06
DK0795024T3 (da) 2003-04-22
JPH10510705A (ja) 1998-10-20
US5840552A (en) 1998-11-24
JP3684576B2 (ja) 2005-08-17
ATE232907T1 (de) 2003-03-15
AU699577B2 (en) 1998-12-10
GB9423970D0 (en) 1995-01-11

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8339 Ceased/non-payment of the annual fee