ATE232907T1 - Enantiosektive herstellung pharmazeutisch aktiver sulfoxide durch biooxidation - Google Patents

Enantiosektive herstellung pharmazeutisch aktiver sulfoxide durch biooxidation

Info

Publication number
ATE232907T1
ATE232907T1 AT95939460T AT95939460T ATE232907T1 AT E232907 T1 ATE232907 T1 AT E232907T1 AT 95939460 T AT95939460 T AT 95939460T AT 95939460 T AT95939460 T AT 95939460T AT E232907 T1 ATE232907 T1 AT E232907T1
Authority
AT
Austria
Prior art keywords
pct
pharmaceutically active
enantiosective
biooxidation
production
Prior art date
Application number
AT95939460T
Other languages
English (en)
Inventor
Robert Holt
Per Lindberg
Christopher Reeve
Stephen Taylor
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE232907T1 publication Critical patent/ATE232907T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT95939460T 1994-11-28 1995-11-27 Enantiosektive herstellung pharmazeutisch aktiver sulfoxide durch biooxidation ATE232907T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9423970A GB9423970D0 (en) 1994-11-28 1994-11-28 Oxidation
PCT/SE1995/001415 WO1996017076A1 (en) 1994-11-28 1995-11-27 Enantioselective preparation of pharmaceutically active sulfoxides by biooxidation

Publications (1)

Publication Number Publication Date
ATE232907T1 true ATE232907T1 (de) 2003-03-15

Family

ID=10765078

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95939460T ATE232907T1 (de) 1994-11-28 1995-11-27 Enantiosektive herstellung pharmazeutisch aktiver sulfoxide durch biooxidation

Country Status (11)

Country Link
US (1) US5840552A (de)
EP (1) EP0795024B1 (de)
JP (1) JP3684576B2 (de)
AT (1) ATE232907T1 (de)
AU (1) AU699577B2 (de)
CA (1) CA2203999A1 (de)
DE (1) DE69529686T2 (de)
DK (1) DK0795024T3 (de)
ES (1) ES2191066T3 (de)
GB (1) GB9423970D0 (de)
WO (1) WO1996017076A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE504459C2 (sv) * 1994-07-15 1997-02-17 Astra Ab Förfarande för framställning av substituerade sulfoxider
GB9423968D0 (en) * 1994-11-28 1995-01-11 Astra Ab Resolution
GB9423970D0 (en) * 1994-11-28 1995-01-11 Astra Ab Oxidation
SE510650C2 (sv) 1997-05-30 1999-06-14 Astra Ab Ny förening
CN1268137A (zh) 1997-07-03 2000-09-27 杜邦药品公司 治疗神经失调的咪唑并嘧啶和咪唑并吡啶
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
SE9900274D0 (sv) 1999-01-28 1999-01-28 Astra Ab New compound
AU6727700A (en) * 1999-08-25 2001-03-19 Takeda Chemical Industries Ltd. Process for the preparation of optically active sulfoxide derivatives
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6780880B1 (en) * 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
DE60124692T2 (de) 2000-04-28 2007-09-13 Takeda Pharmaceutical Co. Ltd. Verfahren zur herstellung von optisch-aktiven sulfoxid-derivaten
DE10254167A1 (de) 2002-11-20 2004-06-09 Icon Genetics Ag Verfahren zur Kontrolle von zellulären Prozessen in Pflanzen
AR042278A1 (es) 2002-12-06 2005-06-15 Altana Pharma Ag Un procedimiento para la preparacion de (s) - pantoprazol
BRPI0310118B1 (pt) 2002-12-06 2015-10-20 Altana Pharma Ag processo para a preparação de inibidores de bomba de próton (ppi) opticamente puro possuindo uma estrutura de sulfinila
EP1801110A1 (de) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Argininsalz des Esomeprazols
AU2006345861B2 (en) 2006-07-05 2012-07-12 Lupin Limited Process for the preparation of optically pure or optically enriched enantiomers of sulphoxide compounds
SI2510089T1 (sl) 2009-12-08 2015-12-31 Codexis, Inc. Sinteza prazolnih spojin
CZ2010790A3 (cs) * 2010-11-01 2011-08-03 Zentiva, K.S. Kmen mikroorganismu Bacillus sp. B71 CCM 7718
EP2649187B1 (de) 2010-12-08 2017-11-22 Codexis, Inc. Biokatalysatoren und verfahren zur synthese von armodafinil
CN108239618A (zh) * 2016-12-23 2018-07-03 浙江京新药业股份有限公司 共表达环己酮单加氧酶和异丙醇脱氢酶的基因工程菌及其应用
CN108251466B (zh) * 2016-12-28 2021-07-02 浙江京新药业股份有限公司 一种酶法合成埃索美拉唑的方法
CN107418923B (zh) 2017-09-20 2018-03-23 华东理工大学 伯克霍尔德菌及其应用
CN113461663B (zh) * 2020-03-30 2023-11-28 江苏奥赛康药业有限公司 一种质子泵抑制剂艾司奥美拉唑钠的膜分离纯化方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US5049674A (en) * 1989-12-20 1991-09-17 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
PL165898B1 (pl) * 1990-06-20 1995-02-28 Astra Ab Sposób wytwarzania nowych pochodnych dwualkoksyplrydynylobenzlmldazolu PL
DE4035455A1 (de) * 1990-11-08 1992-05-14 Byk Gulden Lomberg Chem Fab Enantiomerentrennung
TNSN95063A1 (fr) * 1994-05-27 1996-02-06 Astra Ab Nouveaux benzimidazoles substitues
TNSN95062A1 (fr) * 1994-05-27 1996-02-06 Astra Ab Nouveaux derives dialkoxy-pyridinyle-benzimidazole
GB9423970D0 (en) * 1994-11-28 1995-01-11 Astra Ab Oxidation

Also Published As

Publication number Publication date
EP0795024B1 (de) 2003-02-19
EP0795024A1 (de) 1997-09-17
CA2203999A1 (en) 1996-06-06
AU699577B2 (en) 1998-12-10
JPH10510705A (ja) 1998-10-20
GB9423970D0 (en) 1995-01-11
ES2191066T3 (es) 2003-09-01
DE69529686D1 (de) 2003-03-27
DK0795024T3 (da) 2003-04-22
AU4126996A (en) 1996-06-19
US5840552A (en) 1998-11-24
WO1996017076A1 (en) 1996-06-06
JP3684576B2 (ja) 2005-08-17
DE69529686T2 (de) 2004-01-15

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