NO970212D0 - Fremgangsmåte for fremstilling av enantiomerene av O-demetyltramadol - Google Patents

Fremgangsmåte for fremstilling av enantiomerene av O-demetyltramadol

Info

Publication number
NO970212D0
NO970212D0 NO970212A NO970212A NO970212D0 NO 970212 D0 NO970212 D0 NO 970212D0 NO 970212 A NO970212 A NO 970212A NO 970212 A NO970212 A NO 970212A NO 970212 D0 NO970212 D0 NO 970212D0
Authority
NO
Norway
Prior art keywords
demethyltramadol
enantiomers
preparation
Prior art date
Application number
NO970212A
Other languages
English (en)
Other versions
NO970212L (no
NO306943B1 (no
Inventor
Helmut Buschmann
Werner Winter
Ivars Graudums
Peter Jansen
Wolfgang Werner A Strassburger
Elmar Josef Friedrichs
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of NO970212D0 publication Critical patent/NO970212D0/no
Publication of NO970212L publication Critical patent/NO970212L/no
Publication of NO306943B1 publication Critical patent/NO306943B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO970212A 1996-01-19 1997-01-17 Fremgangsmåte for fremstilling av enantiomerene av O- demetyltramadol NO306943B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19601744A DE19601744C2 (de) 1996-01-19 1996-01-19 Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol

Publications (3)

Publication Number Publication Date
NO970212D0 true NO970212D0 (no) 1997-01-17
NO970212L NO970212L (no) 1997-07-21
NO306943B1 NO306943B1 (no) 2000-01-17

Family

ID=7783111

Family Applications (1)

Application Number Title Priority Date Filing Date
NO970212A NO306943B1 (no) 1996-01-19 1997-01-17 Fremgangsmåte for fremstilling av enantiomerene av O- demetyltramadol

Country Status (32)

Country Link
US (1) US5728885A (no)
EP (1) EP0786450B1 (no)
JP (1) JPH09216857A (no)
KR (1) KR100507396B1 (no)
CN (1) CN1073085C (no)
AR (1) AR005390A1 (no)
AT (1) ATE191454T1 (no)
AU (1) AU705195B2 (no)
BR (1) BR9700079A (no)
CA (1) CA2195372C (no)
CO (1) CO4520186A1 (no)
CZ (1) CZ292427B6 (no)
DE (2) DE19601744C2 (no)
DK (1) DK0786450T3 (no)
ES (1) ES2147341T3 (no)
GR (1) GR3033390T3 (no)
HK (1) HK1004810A1 (no)
HU (1) HU223661B1 (no)
IL (1) IL120029A (no)
IN (1) IN181540B (no)
MY (1) MY116593A (no)
NO (1) NO306943B1 (no)
NZ (1) NZ299998A (no)
PE (1) PE29998A1 (no)
PL (1) PL187373B1 (no)
PT (1) PT786450E (no)
RU (1) RU2185371C2 (no)
SI (1) SI0786450T1 (no)
SK (1) SK282629B6 (no)
UA (1) UA45342C2 (no)
UY (1) UY24438A1 (no)
ZA (1) ZA97367B (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19712398A1 (de) * 1997-03-25 1998-10-01 Gruenenthal Gmbh Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel
PE20010623A1 (es) 1999-10-05 2001-07-07 Gruenenthal Chemie Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
EP1313460A2 (en) * 1999-11-09 2003-05-28 Darwin Discovery Limited Therapeutic use and formulation of (-)-tramadol
DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
DE10108122A1 (de) 2001-02-21 2002-10-02 Gruenenthal Gmbh Arzneimittel auf Basis von Tramadol
DE10108123A1 (de) * 2001-02-21 2002-10-02 Gruenenthal Gmbh Wirkstoffkombination
DE10109763A1 (de) * 2001-02-28 2002-09-05 Gruenenthal Gmbh Pharmazeutische Salze
US20050176790A1 (en) 2001-02-28 2005-08-11 Johannes Bartholomaus Pharmaceutical salts
CN1289071C (zh) 2001-03-16 2006-12-13 Dmi生物科学公司 曲马朵物质在制备用于延缓男性射精的药物中的用途
US6649783B2 (en) * 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
AU2002364517A1 (en) 2001-11-30 2003-06-17 Sepracor Inc. Tramadol analogs and uses thereof
US20040248979A1 (en) * 2003-06-03 2004-12-09 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
DE102005033732B4 (de) * 2005-05-27 2014-02-13 Grünenthal GmbH Trennung stereoisomerer N,N-Dialkylamino-2-alkyl-3-hydroxy-3-phenyl-alkane
EP1785412A1 (en) * 2005-11-14 2007-05-16 IPCA Laboratories Limited Tramadol recovery process
KR20140054312A (ko) * 2007-02-12 2014-05-08 디엠아이 바이오사이언시스 인코포레이티드 조루 및 발기부전을 동시에 치료하는 방법
CA2677691C (en) 2007-02-12 2012-07-31 David Bar-Or Reducing side effects of tramadol
WO2011110595A1 (de) * 2010-03-10 2011-09-15 Grünenthal GmbH Kristalline salze und/oder cokristalle von o-desmethyltramadol
EP2383255A1 (en) 2010-04-28 2011-11-02 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
EP2530072A1 (en) 2011-06-03 2012-12-05 Lacer, S.A. New compounds, synthesis and use thereof in the treatment of pain
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol
EP3684753A1 (en) 2017-09-18 2020-07-29 R L Fine Chem Private Limited A process for preparation of o-desmethyltramadol and salts thereof
US11000488B2 (en) 2019-03-22 2021-05-11 Syntrix Biosystems Inc. Treating pain using desmetramadol
CN118108610A (zh) * 2024-04-30 2024-05-31 山东新华制药股份有限公司 盐酸去甲曲马多的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1518663A1 (de) * 1965-08-02 1969-12-18 Gruenenthal Chemie Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
JP3381190B2 (ja) 1991-09-06 2003-02-24 マクニーラブ・インコーポレーテツド トラマドール物質およびアセトアミノフェンを含んでなる組成物並びにそれの使用
ES2096726T3 (es) 1991-09-06 1997-03-16 Mcneilab Inc Composiciones que contienen tramadol y cualquier codeina, oxicodona o hidrocodona, y su utilizacion.
JPH06122686A (ja) * 1992-10-12 1994-05-06 Fujisawa Pharmaceut Co Ltd ラセミ体の光学分割法

Also Published As

Publication number Publication date
MY116593A (en) 2004-02-28
NO970212L (no) 1997-07-21
DE19601744C2 (de) 1998-04-16
DK0786450T3 (da) 2000-07-10
CN1073085C (zh) 2001-10-17
US5728885A (en) 1998-03-17
DE59604885D1 (de) 2000-05-11
AU1221697A (en) 1997-07-24
CZ15797A3 (cs) 1998-05-13
PL187373B1 (pl) 2004-06-30
HU223661B1 (hu) 2004-11-29
NO306943B1 (no) 2000-01-17
CO4520186A1 (es) 1997-10-15
CN1167107A (zh) 1997-12-10
ATE191454T1 (de) 2000-04-15
SK6797A3 (en) 1997-08-06
CZ292427B6 (cs) 2003-09-17
CA2195372A1 (en) 1997-07-20
HU9700140D0 (en) 1997-03-28
GR3033390T3 (en) 2000-09-29
ZA97367B (en) 1997-07-17
BR9700079A (pt) 1998-11-10
HK1004810A1 (en) 1998-12-11
EP0786450A3 (de) 1997-10-15
PL318002A1 (en) 1997-07-21
SI0786450T1 (en) 2000-08-31
CA2195372C (en) 2005-08-30
NZ299998A (en) 1998-01-26
KR100507396B1 (ko) 2005-12-20
AU705195B2 (en) 1999-05-20
IL120029A (en) 2000-01-31
DE19601744A1 (de) 1997-07-31
IN181540B (no) 1998-07-11
SK282629B6 (sk) 2002-10-08
UY24438A1 (es) 1997-01-10
EP0786450A2 (de) 1997-07-30
UA45342C2 (uk) 2002-04-15
PT786450E (pt) 2000-08-31
MX9700523A (es) 1997-07-31
JPH09216857A (ja) 1997-08-19
PE29998A1 (es) 1998-08-08
ES2147341T3 (es) 2000-09-01
EP0786450B1 (de) 2000-04-05
KR970059161A (ko) 1997-08-12
RU2185371C2 (ru) 2002-07-20
IL120029A0 (en) 1997-04-15
HUP9700140A3 (en) 2000-03-28
HUP9700140A2 (hu) 1998-01-28
AR005390A1 (es) 1999-04-28

Similar Documents

Publication Publication Date Title
NO970212D0 (no) Fremgangsmåte for fremstilling av enantiomerene av O-demetyltramadol
NO20011936D0 (no) Fremgangsmåte for fremstilling av Citalopram
FI102474B1 (fi) Menetelmä moniarvoisten alkoholien valmistamiseksi
NO976121L (no) FremgangsmÕte for fremstilling av karbonylforbindelser
NO992375L (no) FremgangsmÕte for fremstilling av benzylethere
NO20001728D0 (no) Fremgangsmåte for fremstilling av chirale forbindelser
NO20000189L (no) Fremgangsmõte for fremstilling av heparin
NO972402D0 (no) Fremgangsmåte for fremstilling av bærere
NO983068D0 (no) FremgangsmÕte for fremstilling av bis-syklopentadienyl-dien komplekser
NO20024058D0 (no) Fremgangsmåte for fremstilling av et oksazolyletanolderivat
NO20003454D0 (no) FremgangsmÕte for fremstilling av (-)cis-3-hydroksy-1-metyl-4-
NO20062796L (no) Fremgangsmate for fremstilling av en dihydroksyaminoforbindelse
NO996432L (no) Fremgangsmåte for fremstilling av 4-substituert-1H-indol-3- glykosamider
NO985535D0 (no) FremgangsmÕte for fremstilling av 1,3-alkandioler
NO984905L (no) FremgangsmÕte for fremstilling av b°rstevarer
NO980316D0 (no) Fremgangsmåte for fremstilling av polymerisater av N-vinylkarprolaktam
NO972682D0 (no) Ny fremgangsmåte for fremstilling av sameridin
NO20012811D0 (no) Fremgangsmåte for fremstilling av p-klorfenyl-propanol- derivat
NO991055L (no) FremgangsmÕte for fremstilling av dinitratestere
NO20013219L (no) Fremgangsmåte for fremstilling av trinatrium-pentacyanoamino- ferrat (II)
NO20003077D0 (no) FremgangsmÕte for fremstilling av klorbenzooksazolen
NO972129D0 (no) Fremgangsmåte for fremstilling av 1-halo-3-trialkylsilanyl-benzenderivater
NO179866C (no) Fremgangsmåte for fremstilling av indoler
NO20002476D0 (no) FremgangsmÕte for fremstilling av formylimidazoler
NO994557D0 (no) Fremgangsmaate for fremstilling av arylaminotriazolopyridiner

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees