ATE253579T1 - Verfahren zur herstellung eines enantiomers von narwedin - Google Patents
Verfahren zur herstellung eines enantiomers von narwedinInfo
- Publication number
- ATE253579T1 ATE253579T1 AT98915005T AT98915005T ATE253579T1 AT E253579 T1 ATE253579 T1 AT E253579T1 AT 98915005 T AT98915005 T AT 98915005T AT 98915005 T AT98915005 T AT 98915005T AT E253579 T1 ATE253579 T1 AT E253579T1
- Authority
- AT
- Austria
- Prior art keywords
- narwedine
- enantiomer
- producing
- solvent
- single enantiomer
- Prior art date
Links
- QENVUHCAYXAROT-UHFFFAOYSA-N Galanthaminon Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(=O)C=C2 QENVUHCAYXAROT-UHFFFAOYSA-N 0.000 title abstract 4
- QENVUHCAYXAROT-YOEHRIQHSA-N Narwedine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1CC(=O)C=C2 QENVUHCAYXAROT-YOEHRIQHSA-N 0.000 title abstract 4
- WCRYNEMFWLZAAZ-WMLDXEAASA-N Narwedine Natural products COc1ccc2CCCC[C@@]34C=CC(=O)C[C@@H]3Oc1c24 WCRYNEMFWLZAAZ-WMLDXEAASA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001412 amines Chemical class 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 238000010899 nucleation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- VMXUWOKSQNHOCA-UKTHLTGXSA-N ranitidine Chemical compound [O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-UKTHLTGXSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9707413.2A GB9707413D0 (en) | 1997-04-11 | 1997-04-11 | Process |
| PCT/GB1998/001029 WO1998046610A1 (en) | 1997-04-11 | 1998-04-08 | Process for preparing single enantiomer narwedine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE253579T1 true ATE253579T1 (de) | 2003-11-15 |
Family
ID=10810680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98915005T ATE253579T1 (de) | 1997-04-11 | 1998-04-08 | Verfahren zur herstellung eines enantiomers von narwedin |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6392038B1 (de) |
| EP (1) | EP0971930B1 (de) |
| JP (1) | JP4322317B2 (de) |
| KR (1) | KR100523125B1 (de) |
| AT (1) | ATE253579T1 (de) |
| AU (1) | AU726812B2 (de) |
| CA (1) | CA2284976C (de) |
| DE (1) | DE69819479T2 (de) |
| DK (1) | DK0971930T3 (de) |
| ES (1) | ES2209125T3 (de) |
| GB (1) | GB9707413D0 (de) |
| NO (1) | NO325949B1 (de) |
| NZ (1) | NZ337962A (de) |
| PT (1) | PT971930E (de) |
| WO (1) | WO1998046610A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1670767B2 (de) * | 2003-09-26 | 2014-10-29 | ScinoPharm Taiwan, Ltd. | Optische trennung eines narwedinamidderivats |
| US20050142193A1 (en) * | 2003-12-31 | 2005-06-30 | Lijuan Tang | Galantamine formulations |
| CA2551946A1 (en) * | 2003-12-31 | 2005-07-21 | Actavis Group Hf | Immediate, controlled and sustained release formulations of galantamine |
| WO2006018703A2 (en) * | 2004-08-16 | 2006-02-23 | Ranbaxy Laboratories Limited | Processes for preparation of narwedine and its use in the synthesis of galantamine |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5428159A (en) * | 1994-04-08 | 1995-06-27 | Ciba-Geigy Corporation | Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine |
| PL184590B1 (pl) * | 1994-10-21 | 2002-11-29 | Sanochemia Pharmazeutika Ag | Sposób wytwarzania pochodnych a heksahydro H benzofuro[ a ef][ ] benzoazepiny sposób odbromowania tych pochodnych sposób wytwarzania związków typu N demetylobromo i epibromo galantaminy oraz nowe związki z określonego zbioru |
-
1997
- 1997-04-11 GB GBGB9707413.2A patent/GB9707413D0/en active Pending
-
1998
- 1998-04-08 ES ES98915005T patent/ES2209125T3/es not_active Expired - Lifetime
- 1998-04-08 CA CA002284976A patent/CA2284976C/en not_active Expired - Lifetime
- 1998-04-08 JP JP54359598A patent/JP4322317B2/ja not_active Expired - Lifetime
- 1998-04-08 WO PCT/GB1998/001029 patent/WO1998046610A1/en not_active Ceased
- 1998-04-08 DE DE69819479T patent/DE69819479T2/de not_active Expired - Lifetime
- 1998-04-08 PT PT98915005T patent/PT971930E/pt unknown
- 1998-04-08 AT AT98915005T patent/ATE253579T1/de active
- 1998-04-08 US US09/402,722 patent/US6392038B1/en not_active Expired - Lifetime
- 1998-04-08 DK DK98915005T patent/DK0971930T3/da active
- 1998-04-08 AU AU69296/98A patent/AU726812B2/en not_active Expired
- 1998-04-08 KR KR10-1999-7009195A patent/KR100523125B1/ko not_active Expired - Lifetime
- 1998-04-08 EP EP98915005A patent/EP0971930B1/de not_active Expired - Lifetime
- 1998-04-08 NZ NZ337962A patent/NZ337962A/en not_active IP Right Cessation
-
1999
- 1999-10-08 NO NO19994928A patent/NO325949B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO994928L (no) | 1999-10-08 |
| CA2284976A1 (en) | 1998-10-22 |
| AU726812B2 (en) | 2000-11-23 |
| JP2001518911A (ja) | 2001-10-16 |
| ES2209125T3 (es) | 2004-06-16 |
| DE69819479D1 (de) | 2003-12-11 |
| DK0971930T3 (da) | 2004-01-26 |
| EP0971930A1 (de) | 2000-01-19 |
| JP4322317B2 (ja) | 2009-08-26 |
| CA2284976C (en) | 2006-10-17 |
| KR20010006117A (ko) | 2001-01-26 |
| GB9707413D0 (en) | 1997-05-28 |
| EP0971930B1 (de) | 2003-11-05 |
| DE69819479T2 (de) | 2004-08-26 |
| NO325949B1 (no) | 2008-08-25 |
| NO994928D0 (no) | 1999-10-08 |
| PT971930E (pt) | 2004-02-27 |
| NZ337962A (en) | 2001-05-25 |
| KR100523125B1 (ko) | 2005-10-19 |
| US6392038B1 (en) | 2002-05-21 |
| WO1998046610A1 (en) | 1998-10-22 |
| AU6929698A (en) | 1998-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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