NO994928L - FremgangsmÕte ved fremstilling av enkelt-enantiomer narwedine - Google Patents

FremgangsmÕte ved fremstilling av enkelt-enantiomer narwedine

Info

Publication number
NO994928L
NO994928L NO994928A NO994928A NO994928L NO 994928 L NO994928 L NO 994928L NO 994928 A NO994928 A NO 994928A NO 994928 A NO994928 A NO 994928A NO 994928 L NO994928 L NO 994928L
Authority
NO
Norway
Prior art keywords
narwedine
single enantiomer
preparation
solvent
amine base
Prior art date
Application number
NO994928A
Other languages
English (en)
Other versions
NO994928D0 (no
NO325949B1 (no
Inventor
Gerard Andrew Potter
Peter David Tiffin
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO994928D0 publication Critical patent/NO994928D0/no
Publication of NO994928L publication Critical patent/NO994928L/no
Publication of NO325949B1 publication Critical patent/NO325949B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
NO19994928A 1997-04-11 1999-10-08 Fremgangsmate ved fremstilling av hovedsakelig enkelt-enantiomer narwedin NO325949B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9707413.2A GB9707413D0 (en) 1997-04-11 1997-04-11 Process
PCT/GB1998/001029 WO1998046610A1 (en) 1997-04-11 1998-04-08 Process for preparing single enantiomer narwedine

Publications (3)

Publication Number Publication Date
NO994928D0 NO994928D0 (no) 1999-10-08
NO994928L true NO994928L (no) 1999-10-08
NO325949B1 NO325949B1 (no) 2008-08-25

Family

ID=10810680

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19994928A NO325949B1 (no) 1997-04-11 1999-10-08 Fremgangsmate ved fremstilling av hovedsakelig enkelt-enantiomer narwedin

Country Status (15)

Country Link
US (1) US6392038B1 (no)
EP (1) EP0971930B1 (no)
JP (1) JP4322317B2 (no)
KR (1) KR100523125B1 (no)
AT (1) ATE253579T1 (no)
AU (1) AU726812B2 (no)
CA (1) CA2284976C (no)
DE (1) DE69819479T2 (no)
DK (1) DK0971930T3 (no)
ES (1) ES2209125T3 (no)
GB (1) GB9707413D0 (no)
NO (1) NO325949B1 (no)
NZ (1) NZ337962A (no)
PT (1) PT971930E (no)
WO (1) WO1998046610A1 (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7307162B2 (en) * 2003-09-26 2007-12-11 Scinopharm Taiwan, Ltd. Resolution of a narwedine amide derivative
CA2552114A1 (en) * 2003-12-31 2005-07-21 Actavis Group Hf Solid dosage formulations of galantamine
WO2005065661A2 (en) * 2003-12-31 2005-07-21 Actavis Group Hf Immediate, controlled and sustained release formulations of galanthamine
WO2006046096A2 (en) * 2004-08-16 2006-05-04 Ranbaxy Laboratories Limited A polymorphic form of narwedine and its use in the synthesis of galantamine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428159A (en) * 1994-04-08 1995-06-27 Ciba-Geigy Corporation Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine
BR9509406A (pt) * 1994-10-21 1998-11-03 Waldheim Pharmazeutica Ges M B Processo para a preparação de 4a,5,9,10,11,12,-hedaxidro-6h-benzofuro(3a,3,2,-ef) [2] benzazepina

Also Published As

Publication number Publication date
NO994928D0 (no) 1999-10-08
ES2209125T3 (es) 2004-06-16
CA2284976C (en) 2006-10-17
US6392038B1 (en) 2002-05-21
EP0971930B1 (en) 2003-11-05
PT971930E (pt) 2004-02-27
ATE253579T1 (de) 2003-11-15
AU6929698A (en) 1998-11-11
GB9707413D0 (en) 1997-05-28
KR100523125B1 (ko) 2005-10-19
KR20010006117A (ko) 2001-01-26
NZ337962A (en) 2001-05-25
NO325949B1 (no) 2008-08-25
AU726812B2 (en) 2000-11-23
JP4322317B2 (ja) 2009-08-26
EP0971930A1 (en) 2000-01-19
DE69819479D1 (de) 2003-12-11
DK0971930T3 (da) 2004-01-26
JP2001518911A (ja) 2001-10-16
CA2284976A1 (en) 1998-10-22
WO1998046610A1 (en) 1998-10-22
DE69819479T2 (de) 2004-08-26

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Legal Events

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