UY23705A1 - Microesferas de proteina vegetal hidrolizada y metodos para la preparacion y uso de las mismas. - Google Patents
Microesferas de proteina vegetal hidrolizada y metodos para la preparacion y uso de las mismas.Info
- Publication number
- UY23705A1 UY23705A1 UY23705A UY23705A UY23705A1 UY 23705 A1 UY23705 A1 UY 23705A1 UY 23705 A UY23705 A UY 23705A UY 23705 A UY23705 A UY 23705A UY 23705 A1 UY23705 A1 UY 23705A1
- Authority
- UY
- Uruguay
- Prior art keywords
- vegetable protein
- microspheres
- hydrolyzed vegetable
- protein
- hydrolyzed
- Prior art date
Links
- 239000004005 microsphere Substances 0.000 title abstract 9
- 108010082495 Dietary Plant Proteins Proteins 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 150000001412 amines Chemical class 0.000 abstract 3
- 239000000243 solution Substances 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- KWYUFKZDYYNOTN-UHFFFAOYSA-M potassium hydroxide Inorganic materials [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 2
- 235000018102 proteins Nutrition 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 102000055006 Calcitonin Human genes 0.000 abstract 1
- 108060001064 Calcitonin Proteins 0.000 abstract 1
- XUEGVRUGKRHCCX-UHFFFAOYSA-N Cl.S(=O)(=O)=C1CC=CC=C1 Chemical compound Cl.S(=O)(=O)=C1CC=CC=C1 XUEGVRUGKRHCCX-UHFFFAOYSA-N 0.000 abstract 1
- 102000003951 Erythropoietin Human genes 0.000 abstract 1
- 108090000394 Erythropoietin Proteins 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 108010064851 Plant Proteins Proteins 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 108010073771 Soybean Proteins Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000012670 alkaline solution Substances 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 abstract 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 abstract 1
- 229960004015 calcitonin Drugs 0.000 abstract 1
- 229940105423 erythropoietin Drugs 0.000 abstract 1
- 239000000945 filler Substances 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 235000021118 plant-derived protein Nutrition 0.000 abstract 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 1
- 229940001941 soy protein Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
El presente invento se refiere a proteínas vegetales hidrolizadas y a microesferas hechas a partir de las mismas. Las microesferas encapsulan de modo liberable agentes activos y son adecuadas para administración oral a mamíferos. También se revelan métodos para la preparación de tales microesferas. Dicha microesfera para encapsular una carga, que tiene un diámetro igual o menor a 10 micras, comprende una proteína vegetal hidrolizada modificada con un agente modificador de amina reactiva. La proteína vegetal hidrolizada comprende proteína de soja hidrolizada por ácido. El agente modificador de la amina reactiva se elige del grupo consistente en cloruro de sulfonil benceno y cloruro de benzoilo. La composición encapsulada dentro de la microesfera comprende un agente biológicamente activo. Este agente comprende un anticuerpo monoclonal, insulina, calcitonina, o eritropoyetina. El método para preparar una microesfera de proteína vegetal hidrolizada modificada comprende: a) mezclar una proteína vegetal hidrolizada con una solución alcalina acuosa (comprende hidróxido de potasio o de sodio) para formar una solución; b) tratar dicha solución con un agente reactivo a la amina para formar una mezcla que contenga una proteína vegetal hidrolizada modificada; c) recuperar dicha proteína vegetal hidrolizada modificada; d) incubar dicha proteína en una solución ácida acuosa para formar dichas microesferas; y e) recoger dichas microesferas de proteína.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99550892A | 1992-12-21 | 1992-12-21 | |
| US08/051,739 US5401516A (en) | 1992-12-21 | 1993-04-22 | Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY23705A1 true UY23705A1 (es) | 1993-12-24 |
Family
ID=26729780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY23705A UY23705A1 (es) | 1992-12-21 | 1993-12-21 | Microesferas de proteina vegetal hidrolizada y metodos para la preparacion y uso de las mismas. |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US5401516A (es) |
| EP (1) | EP0674507A4 (es) |
| JP (1) | JPH08507043A (es) |
| CN (1) | CN1094611A (es) |
| AU (1) | AU6017194A (es) |
| CA (1) | CA2151818A1 (es) |
| IL (1) | IL108079A0 (es) |
| IS (1) | IS1649B (es) |
| MA (1) | MA23065A1 (es) |
| MX (1) | MX9400166A (es) |
| UY (1) | UY23705A1 (es) |
| WO (1) | WO1994014420A1 (es) |
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- 1993-12-19 IL IL10807993A patent/IL108079A0/xx unknown
- 1993-12-21 WO PCT/US1993/012700 patent/WO1994014420A1/en not_active Application Discontinuation
- 1993-12-21 UY UY23705A patent/UY23705A1/es unknown
- 1993-12-21 CN CN93119951A patent/CN1094611A/zh active Pending
- 1993-12-21 MA MA23375A patent/MA23065A1/fr unknown
- 1993-12-21 EP EP94906480A patent/EP0674507A4/en not_active Withdrawn
- 1993-12-21 CA CA002151818A patent/CA2151818A1/en not_active Abandoned
- 1993-12-21 IS IS4110A patent/IS1649B/is unknown
- 1993-12-21 JP JP6515498A patent/JPH08507043A/ja active Pending
- 1993-12-21 AU AU60171/94A patent/AU6017194A/en not_active Abandoned
-
1994
- 1994-01-03 MX MX9400166A patent/MX9400166A/es unknown
- 1994-04-25 US US08/233,281 patent/US5540939A/en not_active Expired - Fee Related
- 1994-11-21 US US08/342,900 patent/US5972387A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2151818A1 (en) | 1994-07-07 |
| EP0674507A1 (en) | 1995-10-04 |
| US5401516A (en) | 1995-03-28 |
| MA23065A1 (fr) | 1994-07-01 |
| AU6017194A (en) | 1994-07-19 |
| MX9400166A (es) | 1994-07-29 |
| IL108079A0 (en) | 1994-04-12 |
| US5540939A (en) | 1996-07-30 |
| IS1649B (is) | 1997-03-25 |
| CN1094611A (zh) | 1994-11-09 |
| US5972387A (en) | 1999-10-26 |
| WO1994014420A1 (en) | 1994-07-07 |
| EP0674507A4 (en) | 1996-09-25 |
| IS4110A (is) | 1994-06-22 |
| JPH08507043A (ja) | 1996-07-30 |
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