Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
  • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
  • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
  • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
  • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
  • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
  • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
  • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
  • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
  • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
  • A23L33/22—Comminuted fibrous parts of plants, e.g. bagasse or pulp
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
  • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P25/00—Drugs for disorders of the nervous system
  • A61P25/08—Antiepileptics; Anticonvulsants
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P3/00—Drugs for disorders of the metabolism
  • A61P3/04—Anorexiants; Antiobesity agents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P3/00—Drugs for disorders of the metabolism
  • A61P3/06—Antihyperlipidemics
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
  • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P9/00—Drugs for disorders of the cardiovascular system
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P9/00—Drugs for disorders of the cardiovascular system
  • A61P9/06—Antiarrhythmics
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P9/00—Drugs for disorders of the cardiovascular system
  • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
  • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
  • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
  • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
  • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
  • C07C309/01—Sulfonic acids
  • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
  • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
  • C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
  • C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
• • A—HUMAN NECESSITIES
  • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
  • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
  • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

• the invention described herein relates to physiologically acceptable salts of L-carnitine and alkanoyl L-carnitine, characterised in that they are non-hygroscopic and stable. Said salts lend themselves favourably to the preparation of solid compositions suitable for oral administration.
• the invention also relates to pharmaceutical and alimentary or nutritional compositions containing them.
• L-carnitine is used in the cardiovascular field for the treatment of acute and chronic myocardial ischaemia, angina pectoris, heart failure and cardiac arrhythmias.
• L-carnitine is administered to uraemic patients on regular haemodialysis treatment to combat muscular asthenia and the onset of muscle cramps.
• the purpose of the invention described herein is to provide stable, non-hygroscopic salts of L-carnitine and the lower alkanoyl L-carnitines that present in addition an increased therapeutic and/or nutritional value compared to the corresponding inner salts.
• the finished product must be packaged in hermetically sealed blister packs to avoid the disagreeable consequences of humidity.
• Sportsmen use L-carnitine or food supplements containing carnitine because it favours the oxidation of fatty acids and makes available a greater amount of energy to skeletal muscle, thus permitting enhanced performance and giving rise to less accumulation of lactic acid in the athletes' muscles.
• European patent 0 434 080 (Lonza) filed on Dec. 21, 1990 describes the use of a non-hygroscopic salt of L-carnitine with L(+)-tartaric acid (salt already described by M ⁇ ller and Strack in Hoppe-Seyler's Z. Physiol. Chem., 353, 618-622, April 1972) for the preparation of solid oral administration forms.
• This salt presents a number of drawbacks, such as, for instance, the release of trimethylamine after prolonged storage, which produces a disagreeable odour due to the characteristic fishy smell of this amine.
• L-(+)-tartaric acid is not capable of furnishing non-hygroscopic salts with alkanoyl L-carnitines such as, for example, acetyl L-carnitine.
• tartrate anion is not capable, alone, of increasing the therapeutic and/or nutritional value of carnitine.
• U.S. Pat. No. 4,602,039 (Sigma Tau) describes the fumarates of L-carnitine, acetyl L-carnitine and propionyl L-carnitine.
• L-carnitine fumarate is highly non-hygroscopic, resisting even better than L-carnitine tartrate in a milieu with a high relative humidity content, this property seems to diminish on increasing the weight of the alkanoyl radical.
• WO98/43945 describes solid compositions suitable for oral administration containing non-hygroscopic salts of L-carnitine and the alkanoyl L-carnitines with 2 aminoethanesulphonic acid (taurine).
• WO98/45250 describes solid compositions suitable for oral administration containing L-carnitine and alkanoyl L-carnitine magnesium tartrate.
• WO98/44918 describes solid compositions suitable for oral administration containing alkanoyl L-carnitine magnesium citrate.
• WO98/47857 describes solid compositions suitable for oral administration containing L-carnitine choline tartrate or alkanoyl L-carnitine choline tartrate.
• WO98/49134 describes solid compositions suitable for oral administration containing L-carnitine and alkanoyl L-carnitine magnesium fumarate.
• the above-mentioned purpose of the invention described herein is therefore to form new pharmacologically acceptable non-hygroscopic, stable salts of both L-carnitine and the lower alkanoyl L-carnitines in which the anionic part contributes to the therapeutic and/or nutritional value of the salt.
• R is hydrogen or a straight or branched lower alkanoyl, with 2-5 carbon atoms.
• R is selected from the group consisting of acetyl, propionyl, butyryl, valeryl and isovaleryl.
• a further object of the invention described herein is a salt of L-carnitine with glycine chloride of general formula (II)
• R is hydrogen or a straight or branched lower alkanoyl, with 2-5 carbon atoms.
• the salts in which R is selected from the group consisting of acetyl, propionyl, butyryl, valeryl and isovaleryl are to be preferred.
• Taurine is one of the most abundant amino acids in the body and is to be found in the central nervous system and in skeletal muscle and is moreover concentrated in the brain and heart. It has been known for some time now to be an essential nutrient during the growth and development of mammals; in fact, it is present in mother's milk and is especially important for the development of the cerebellum and retina. Taurine also has a very important metabolic function: in bile, the bile acids are bound to taurine to form the glycocholic and taurocholic acids, respectively.
• the salts of bile acids possess the important property of lowering the surface tension of solutions. For this reason they are excellent emulsifying agents and perform an important function in the absorption and digestion of lipids in the bowel.
• taurine when bound to L-carnitine performs a complementary function to that performed by L-carnitine.
• taurine is complementary to the subsequent metabolic activity exerted by L-carnitine, i.e. the oxidation of fatty acids for energy production.
• Glycine is an important amino acid widely used as a food supplement both in human nutrition and in the feeding of livestock and pets.
• the non-hygroscopic salt of carnitine with glycine also presents an enhanced therapeutic and/or nutritional value compared to the corresponding inner salt, in that, as already mentioned, the anionic part (glycine) contributes to the therapeutic and/or nutritional value which is therefore no longer determined exclusively by the “carnitine” part of the salt.
• non-hygroscopic salts according to the invention described herein are useful agents in human or animal nutrition both in physiological conditions, i.e. in subjects in a good state of health, and in the malabsorption syndromes observed in children and adults.
• the salts of L-carnitine and the lower alkanoyl L-carnitines according to the invention described herein are non-hygroscopic, are easy to process and are highly stable on storage.
• the filtrate was vacuum dried at 30° C.
• the compounds in the examples mentioned are non-hygroscopic and highly stable.
• composition suitable for the production of tablets is the following:
• Non-hygroscopic salt of L-carnitine according to the invention 500 mg Starch 20 mg Talc 10 mg Ca-stearate 1 mg 531 mg
• a composition suitable for the production of capsules is the following:
• Non-hygroscopic salt of L-carnitine 500 mg Lactose 50 mg Starch 20 mg Talc 5 mg Ca-stearate 2 mg 577 mg

Landscapes

• Chemical & Material Sciences (AREA)
• Organic Chemistry (AREA)
• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Engineering & Computer Science (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Public Health (AREA)
• General Chemical & Material Sciences (AREA)
• General Health & Medical Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• Veterinary Medicine (AREA)
• Pharmacology & Pharmacy (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Medicinal Chemistry (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Diabetes (AREA)
• Hematology (AREA)
• Heart & Thoracic Surgery (AREA)
• Cardiology (AREA)
• Nutrition Science (AREA)
• Botany (AREA)
• Neurology (AREA)
• Mycology (AREA)
• Obesity (AREA)
• Food Science & Technology (AREA)
• Polymers & Plastics (AREA)
• Biomedical Technology (AREA)
• Child & Adolescent Psychology (AREA)
• Neurosurgery (AREA)
• Pain & Pain Management (AREA)
• Physical Education & Sports Medicine (AREA)
• Orthopedic Medicine & Surgery (AREA)
• Urology & Nephrology (AREA)
• Vascular Medicine (AREA)
• Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
• Medicinal Preparation (AREA)
• Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
• Fodder In General (AREA)
• Coloring Foods And Improving Nutritive Qualities (AREA)

Applications Claiming Priority (4)

Publications (2)

Family

ID=11454973

Family Applications (1)

Country Status (25)

Families Citing this family (6)

Citations (3)

Family Cites Families (1)

• 2000
  • 2000-10-31 IT IT2000RM000567A patent/IT1317924B1/it active
• 2001
  • 2001-09-28 SK SK501-2003A patent/SK287133B6/sk not_active IP Right Cessation
  • 2001-09-28 JP JP2002539304A patent/JP4181406B2/ja not_active Expired - Fee Related
  • 2001-09-28 DK DK01976633T patent/DK1330428T3/da active
  • 2001-09-28 CN CNB018182941A patent/CN1219748C/zh not_active Expired - Lifetime
  • 2001-09-28 NZ NZ525333A patent/NZ525333A/en not_active IP Right Cessation
  • 2001-09-28 AU AU9589301A patent/AU9589301A/xx active Pending
  • 2001-09-28 HU HU0302294A patent/HU229989B1/hu not_active IP Right Cessation
  • 2001-09-28 DE DE60115944T patent/DE60115944T2/de not_active Expired - Lifetime
  • 2001-09-28 AT AT01976633T patent/ATE312810T1/de active
  • 2001-09-28 WO PCT/IT2001/000503 patent/WO2002036543A1/en active IP Right Grant
  • 2001-09-28 RU RU2003116133/04A patent/RU2270191C2/ru active
  • 2001-09-28 EP EP01976633A patent/EP1330428B1/en not_active Expired - Lifetime
  • 2001-09-28 US US10/415,472 patent/US7858820B2/en not_active Expired - Lifetime
  • 2001-09-28 SI SI200130462T patent/SI1330428T1/sl unknown
  • 2001-09-28 AU AU2001295893A patent/AU2001295893B2/en not_active Ceased
  • 2001-09-28 BR BRPI0115019A patent/BRPI0115019B1/pt not_active IP Right Cessation
  • 2001-09-28 KR KR1020037005596A patent/KR100764155B1/ko active IP Right Grant
  • 2001-09-28 CA CA2427482A patent/CA2427482C/en not_active Expired - Fee Related
  • 2001-09-28 MX MXPA03003799A patent/MXPA03003799A/es active IP Right Grant
  • 2001-09-28 ES ES01976633T patent/ES2253430T3/es not_active Expired - Lifetime
  • 2001-09-28 CZ CZ20031041A patent/CZ302802B6/cs not_active IP Right Cessation
  • 2001-09-28 PL PL364823A patent/PL205801B1/pl unknown
• 2003
  • 2003-04-30 ZA ZA200303328A patent/ZA200303328B/en unknown
• 2004
  • 2004-06-16 HK HK04104342A patent/HK1061230A1/xx not_active IP Right Cessation
• 2006
  • 2006-01-19 CY CY20061100074T patent/CY1106062T1/el unknown

Patent Citations (4)

Also Published As

Similar Documents

Legal Events