US5445631A - Fluid delivery system - Google Patents

Fluid delivery system Download PDF

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Publication number
US5445631A
US5445631A US08/192,282 US19228294A US5445631A US 5445631 A US5445631 A US 5445631A US 19228294 A US19228294 A US 19228294A US 5445631 A US5445631 A US 5445631A
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US
United States
Prior art keywords
container
vial
capsule
cannula
sliding member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
US08/192,282
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English (en)
Inventor
Tadatoshi Uchida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissho Corp
Asubio Pharma Co Ltd
Original Assignee
Suntory Ltd
Nissho Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd, Nissho Corp filed Critical Suntory Ltd
Assigned to NISSHO CORPORATION, SUNTORY LIMITED reassignment NISSHO CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: UCHIDA, TADATOSHI
Application granted granted Critical
Publication of US5445631A publication Critical patent/US5445631A/en
Assigned to DAIICHI SUNTORY PHARMA CO., LTD. reassignment DAIICHI SUNTORY PHARMA CO., LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SUNTORY LIMITED
Assigned to DAIICHI ASUBIO PHARMA CO., LTD. reassignment DAIICHI ASUBIO PHARMA CO., LTD. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: DAIICHI SUNTORY PHARMA CO., LTD.
Assigned to DAIICHI ASUBIO PHARMA CO., LTD. reassignment DAIICHI ASUBIO PHARMA CO., LTD. ADDRESS CHANGE Assignors: DAIICHI ASUBIO PHARMA CO., LTD.
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3205—Separate rigid or semi-rigid containers joined to each other at their external surfaces
    • B65D81/3211—Separate rigid or semi-rigid containers joined to each other at their external surfaces coaxially and provided with means facilitating admixture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2065—Connecting means having aligning and guiding means

Definitions

  • This invention relates to a fluid delivery system, and more particularly, to such a fluid delivery system including a vial for containing therein a substance, preferably a powder, such as medicament or drug, and a container for containing therein a fluid, preferably a liquid, such as solution or diluent, to mix the powder with the liquid to obtain a medical solution.
  • a vial for containing therein a substance preferably a powder, such as medicament or drug
  • a container for containing therein a fluid preferably a liquid, such as solution or diluent
  • dry medicament such as powdered medicament or freeze-dried medicament
  • a container such as a vial
  • the vial containing the medicament and another container containing a solution or diluent are connected to each other by means of a double-pointed hollow needle or any other communicating pipe, so that the solution is transferred to the vial containing the medicament to dissolve the latter.
  • a fluid delivery system having an object of carrying out an operation in a completely sterile condition has been proposed, such as disclosed in Japanese Unexamined Patent Publications (kohyo) No. 61-501129 (which corresponds to U.S. Pat. No. 4,583,971), (kokai) No. 2-1277 (which corresponds to U.S. Pat. No. 4,936,841), and (kokai) No. 3-37067.
  • a fluid storage and delivery system which cannot expect a complete sterile operation, but capable of optionally selecting the combinations between the medicament and solution and attaining a substantially sterile operation has been proposed, such as disclosed in Japanese Unexamined Patent Publications (kokai) Nos. 59-209535, 62-137056, and 2-4375, or also Japanese Examined Patent Publications (kokoku) No. 2-26506.
  • a capsule accommodating a medicament container and a flexible container containing a solution are connected to each other by a tube, in such a manner that the medicament container is mutually communicated with the flexible container by communicating means provided in the tube and therefore the medicament is mixed with the solution in a sterile condition.
  • capsule accommodating a medicament container is connected by its connecting portion to an opening of a solution container.
  • the connecting portion of the capsule is accompanied with a communicating means providing with a means for controlling the connection order, in such a manner that the medicament container is first pierced by the communicating means and then the solution container is pierced so that the two containers are mutually communicated by the communicating means and therefore the medicament is mixed with the solution in a sterile condition.
  • a medicament container, a communicating means and a solution container are arranged in such an order and covered air tightly with a sheet made of synthetic resin.
  • a container support means is provided between the medicament container and the solution container for supporting them over the sheet, so that the medicament container and the solution container are prevented from accessing toward each other until they are mutually communicated in a sterile condition.
  • JP-A 59-209535 discloses a system comprising a first hermetically sealed flexible container having a flexible wall member, a second container having a detachable stopper and which can be fixed through the wall member, and a stopper detaching means having a portion engaged with the stopper. The stopper comes into engaged with the stopper detaching means through the first and second containers and then the stopper is removed from the second container together with a sealing barrier of the first flexible container, so that the two containers are mutually communicated to allow the mixing of the contents in these containers.
  • JP-A 62-137056 and JP-A 2-4375 discloses a system in which the above-mentioned second container is improved.
  • JP-A 2-26506 discloses a further improved system of that disclosed in the above-mentioned JP-A 59-209535.
  • Unexamined Patent Publication (kokai) No. 4-329956 discloses a sterile mixing apparatus of medicament container in a sealed vial, the apparatus comprising a vial containing therein a medicament, a liquid container, pierceable plug members for hermetically sealing the openings of the vial and the container, respectively, a cannula member having respective edges at both sides.
  • JP-A 4-329956 a special mechanism or means is necessary for retaining the medicament vial so as not to communicate with liquid container until the vial is intentionally pushed down to toward the container by an operator.
  • An object of the present invention is to provide a fluid delivery system which can be easily and surely handled by an operator, such as a doctor, nurse or the like, in a sterile or substantially sterile condition and has a simple construction as compared with the above-mentioned systems known in the prior art.
  • a fluid delivery system comprising: a vial having an opening for containing therein a substance which can be dissolved by a liquid; a container having an opening for containing therein the fluid; pierceable plug members for hermetically sealing said openings of the vial and the container, respectively; a cylindrical capsule having first and second open ends; a sliding member slidably disposed in said capsule and providing with a double-pointed cannula having upper and lower needles; said vial being detachably and fixedly connected to said first open end of the capsule; said container being slidably inserted into said capsule from said second open end thereof; and said lower and upper needles being sealingly pierced and inserted into said plugs of the vial and the container, respectively, so that said vial and said container are communicated to each other through said cannula, when said container is pushed toward said vial.
  • said container has a cylindrical wall portion and a bottom, an auxiliary cover member is put upon said container to air tightly cover said cylindrical wall portion and said bottom thereof, and said cover member is frictionally and slidably fit within said capsule, when said container is inserted into said capsule.
  • a fluid delivery system comprising: a vial having an opening for containing therein a substance which can be dissolved by a liquid; a container having an opening for containing therein the fluid; first and second, pierceable plug members for hermetically sealing said openings of the vial and the container, respectively; a capsule having first and second open ends; a sliding member slidably disposed in said capsule and having a double-pointed cannula having lower and upper needles axially extending toward said first and second open ends, respectively; said vial being detachably and fixedly connected to said first open end of the capsule; said container being slidably inserted into said capsule from said second open end thereof; and means for controlling a movement of said sliding member in such a manner that, when said container is pushed toward said vial, said lower needle of the cannula is first sealingly pierced and inserted into said first plug of the vial so that said cannula is communicated with said vial and
  • FIG. 1 is a cross-sectional view of a first embodiment of a fluid delivery system according to the present invention
  • FIG. 2 is a cross-sectional view of another embodiment of the system similar to that of FIG. 1;
  • FIG. 3 is a cross-sectional view of a still another embodiment of the system.
  • FIG. 4 is a cross-sectional view of a sliding member having a double-pointed cannula used in this system
  • FIG. 5 is a bottom plan view of the sliding member shown in FIG. 4;
  • FIG. 6 is a top plan view of the sliding member
  • FIG. 7 is a cross-sectional view of a sliding member having another cannula.
  • FIGS. 1, 2, and 3 show several embodiments of a fluid delivery system according to the present invention.
  • the system comprises a fluid container 1, a vial 2, a sliding member 3 having a double-pointed cannula and a cylindrical or pipe-like capsule 4.
  • the capsule 4 has a partition wall 41 having a central opening 42 to separate this capsule 4 into two sections 43 and 44, i.e., an upper, slide section 43 having an inner cylindrical bore, within which the sliding member 3 is slidably disposed, and has an upper open end through which the solution container 1 is slidably inserted, and a lower, vial mount section 44 having a bottom open end to which the vial 2 is detachably and fixedly connected.
  • the capsule 4 may be made of any suitable synthetic resin, such as polyetylene, polypropylene, polyestere or the like.
  • the solution container 1 is substantially cylindrical and usually made of glass or synthetic resin, such as polyetylene, polypropylene, polyestere or the like.
  • the container 1 has an inlet opening 11 through which any suitable liquid, such as solution or diluent for transfusion, is filled and then the opening 11 is hermetically sealed by a pierceable, rubber plug 12.
  • the container 1 has a cylindrical wall portion and a bottom and it is preferable that the container 1 is sheathed within an auxiliary sliding cover 5 to air tightly cover the cylindrical wall portion and the bottom of the container 1.
  • the cover 5 is not always necessary to cover entirely the bottom of the container 1, but may be provided with a central open area 51 as illustrated in FIG. 1, although at least the peripheral area of the bottom must be tightly covered by the auxiliary cover 5.
  • Such an auxiliary sliding cover 5 may be made of any suitable material, such as synthetic resin, for example polypropylene, polyetylene, polyvinyl chloride or the like, so that the auxiliary sliding cover 5 is frictionally, air tightly and slidably fit within the capsule 4 when the container 1 is inserted into the capsule 4.
  • the capsule 4 is provided with an annular rib 45 on the inner wall thereof. Therefore, an annular edge of the cover 5 first comes into engage with the annular rib 45 to retain the container 1 within the capsule 4 when the solution container 1 is inserted into the capsule 4. Thus, the solution container 4 is prevented from unintentionally falling down. As described hereinafter in detail, when the container is further pushed down, the cover 5 is allowed to move over the annular rib 45.
  • the vial 2 is substantially cylindrical and usually made of glass and an inlet opening 21 through which the vial 2 is filled with any suitable substance, such as a dry medicament or drug, for example powdered medicament or freeze-dried medicament, not shown in the drawings.
  • the inlet opening 21 is hermetically sealed by a pierceable, rubber plug 22.
  • the vial 2 is provided with a male thread portion 23 around the inlet opening 21 and, on the other hand, the vial mount section 44 of the capsule 4 provided with a female thread portion 46, so that the vial 1 can be detachably and fixedly connected to the vial mount section 44 of the capsule 4 by the thread connection.
  • the male and female thread portions 23 and 46 are arranged in such a manner that, when the vial 1 is fixedly connected to the capsule 4 by the thread connection, the upper surface of the rubber plug 22 of the vial 2 comes into contact with the radial partition wall 41.
  • the sliding member 3 is disposed in the slide section 43 of the capsule 4 so that the sliding member 3 is slidably moved in the axial direction within the cylindrical bore of the capsule 4.
  • the sliding member 3 comprises a cannula providing with upper and lower needles 33 and 34 extending axially toward the upper container 1 and lower vial 2, respectively, a hub 31 and several (four, in the embodiment shown in FIGS. 4-6) slide arms 32 extending axially from the periphery of the hub 31.
  • the hub 31 and the slide arms 32 are integrally formed of any suitable synthetic resin as a single unit.
  • the cannula is usually made of stainless steel, preferably SUS 304, or any hard synthetic resin, providing with upper and lower needles 33 and 34 extending axially up and down toward the container 1 and vial 2, respectively.
  • the hub 31 is usually made of any suitable synthetic resin.
  • the cannula should be made of stainless steel.
  • the cannula should be made of hard synthetic resin, such as ABS resin or polycarbonate.
  • the sliding member 3 including the cannula, the hub 31 and the slide arms 35 can be integrally formed as a single unit.
  • the sliding member 3 When assembling this system, the sliding member 3 is first inserted into the slide section 43 of the capsule 4 so that the slide arms 35 are slidably engaged with the inner bore wall of the capsule 4 to retain the sliding member 3 within the capsule 4. Then, container 1 covered with the auxiliary cover 5 as mentioned above is inserted into the capsule 4 until the annular edge of the cover 5 comes into engage with the annular rib 45. Thus, the container 1 is retained within the capsule 4 so that the solution container 1 is prevented from unintentionally falling down. In this state, if necessary, the container 1 can also be sold and available in the market as a single product or good.
  • the vial 2 containing the medicament therein is connected to the capsule 4, as mentioned above and shown in FIGS. 1-3, by an operator, such as a doctor or nurse, so that the vial 2 and the capsule 4 are fixed to each other by the thread engagement. Then, the container 1 is pushed down so that the cover 5 moves over the annular rib 45. After the rubber plug 12 of the container 1 comes into contact with the upper needle 33 of the cannula, the sliding member 3 is further moved downward with the container 1 and then the lower needle 34 of the cannula comes into contact with rubber plug 22 of the vial 2 through the central opening 42 of the partition wall 41.
  • a movement of the sliding member 3 is controlled in such a manner that the lower needle 34 of the cannula is first sealingly pierced and inserted into the rubber plug 22 of the vial 2 so that the cannula is communicated with the vial 2 and then the upper needle 33 of the cannula is sealingly pierced and inserted into the rubber plug 12 of the fluid container 1 so that both the fluid container 1 and the vial 2 are communicated to each other through the cannula.
  • the cannula in such a manner that the edge of lower needle 34 is made sharper than that of the upper needle 33.
  • the rubber plug 12 of the container 1 is made harder than the rubber plug 22 of the vial 2.
  • a rubber cap 6 is attached to cover the lower needle 34 of the cannula which would prevent a leak of solution from the container 1 through the cannula, if the upper needle 33 was inserted into the rubber plug 12 of the container 1 to communicate with the container 1, before the lower needle 34 was pierced into the rubber plug 22 of the vial 2.
  • the sliding member 3 is provided with braking means to prevent a leak of solution from the container 1.
  • braking means is comprised several legs 7 integrally extending from the hub 31 of the sliding member 3 and engaged with the opening portion of the container 1 by curved portions of projections 8 of the legs 7. Therefore, when the container 1 is pushed down, the sliding member 3 is lowered with the container 1 until the lower needle 34 of the cannula comes into contact with rubber plug 22 of the vial 2 and pierced into the rubber plug 22 of the vial 2 so that the cannula is communicated with the vial 1.
  • the container 1 is moved over the projections 8 of the legs 7 and allowed to move downward so as to widen the legs 7, until the upper needle 33 was inserted into the rubber plug 12 of the container 1 to communicate with the container 1.
  • a stopper means such as an annular recess or undercut portion 47 is formed on an inner wall of the capsule 4. Therefore, when the sliding member 3 is completely lowered to a predetermined position, in other words, when the sliding member 3 comes into contact with the radial partition wall 42, the slide arms 32 of sliding member 3 comes to be engaged with the recess 47 and thus the sliding member 3 is locked.
  • the recess 47 is preferably formed as a sharp edge and on the other hand, the ends of the slide arms 32 are provided with hook portions 35, as shown in FIGS. 4-6, which can be surely engaged with the recess 47.
  • its unfavorable movement such as a raise or kick back thereof due to an elastic force of the rubber cap 6 can effectively prevented.
  • the liquid or solution in the container 1 enters into the vial 2 and the powdered medicament or freeze-dried medicament is mixed with or dissolved in the solution.
  • the vial 2 is removed from the capsule 4.
  • the vial 1 containing the medicament solution is used in the transfusion for a patient.
  • the remaining system including the container 1, the sliding member 3 and the capsule 4 are usually disposed.
  • the lower needle 34 does not protrude from the lower end 48 of the sleeve, as shown in FIG. 1, and thus a safe handling of the system can be ensured, after the vial 1 is removed.
  • the cannula of the sliding member 3 has a single fluid passage 36, as shown in FIGS. 4-6, a cannula having two such passages 37 and 38 may be used, as shown in FIG. 7.
  • the solution can be more rapidly transferred from the container 1 to the vial, since one of the passages 37 and 38 is used as a liquid way and the other is used as an air/gas way.
  • both the capsule 4 and the auxiliary cover 5 are made of synthetic resin, the auxiliary cover 5 is frictionally and air tightly fit within the capsule 4, even if the mutual dimensions therebetween have not been very strictly controlled. Therefore, any possible contamination is effectively prevented and, particularly, unfavorable substance, such as bacterium, is prevented from entering into the slide section 43 of the capsule 4.
  • the fluid delivery system according to the present invention can easily be handled even if the operator is not familiar with the solution for transfusion and dry medicament in this field. Also, any possible errors in the delivery of mixing process for providing the patient can effectively be prevented.

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
  • Medicinal Preparation (AREA)
US08/192,282 1993-02-05 1994-02-04 Fluid delivery system Expired - Fee Related US5445631A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4204193A JPH06239352A (ja) 1993-02-05 1993-02-05 溶解液注入セット
JP5-042041 1993-02-05

Publications (1)

Publication Number Publication Date
US5445631A true US5445631A (en) 1995-08-29

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Family Applications (1)

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US08/192,282 Expired - Fee Related US5445631A (en) 1993-02-05 1994-02-04 Fluid delivery system

Country Status (8)

Country Link
US (1) US5445631A (fr)
EP (1) EP0614653B1 (fr)
JP (1) JPH06239352A (fr)
AT (1) ATE204453T1 (fr)
DE (1) DE69428005T2 (fr)
DK (1) DK0614653T3 (fr)
ES (1) ES2159542T3 (fr)
PT (1) PT614653E (fr)

Cited By (112)

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US5603695A (en) * 1995-06-07 1997-02-18 Erickson; Kim Device for alkalizing local anesthetic injection medication
WO1998017397A1 (fr) * 1996-10-21 1998-04-30 Winkelman James W Dispositif et procede pour separer des echantillons de sang
US5989237A (en) 1997-12-04 1999-11-23 Baxter International Inc. Sliding reconstitution device with seal
US6022339A (en) 1998-09-15 2000-02-08 Baxter International Inc. Sliding reconstitution device for a diluent container
US6253804B1 (en) * 1999-11-05 2001-07-03 Minimed Inc. Needle safe transfer guard
US6277095B1 (en) 1995-10-11 2001-08-21 Science Incorporated Fluid delivery device with full adapter
WO2002062288A1 (fr) 2001-02-02 2002-08-15 Baxter International Inc. Dispositif de reconstitution et son procede d'utilisation
US6453956B2 (en) * 1999-11-05 2002-09-24 Medtronic Minimed, Inc. Needle safe transfer guard
US20030069538A1 (en) * 2001-08-31 2003-04-10 Thomas Pfeifer Apparatus for combining components under sterile conditions
US20030083606A1 (en) * 1998-06-03 2003-05-01 Epstein Gordon Howard Direct dual filling device for sealing agents
US6575205B2 (en) 2000-12-07 2003-06-10 Baxter International Direct dual filling device for sealing agents
US6582415B1 (en) 1998-09-15 2003-06-24 Thomas A. Fowles Sliding reconstitution device for a diluent container
US6644365B1 (en) 2002-04-19 2003-11-11 Baxter International, Inc. Tilting direct dual filling device
US20030231545A1 (en) * 2001-10-09 2003-12-18 Seaton James P. Multi-component handling and delivery system
US20040059312A1 (en) * 2001-01-08 2004-03-25 Pierre Frezza Ampule for packaging and transferring a liquid or a powder for medical use
US20040066706A1 (en) * 2002-10-07 2004-04-08 Donald Barker Apparatus for mixing and dispensing components
US20040186443A1 (en) * 2001-08-21 2004-09-23 Gian-Carlo Covino Fixing device for injection needles
US20040249341A1 (en) * 2003-06-06 2004-12-09 Newbrough Jerry W. Reconstitution device and method of use
US20050203481A1 (en) * 2004-03-10 2005-09-15 P2A Medical Perforating connector with sterile connection
US20050267483A1 (en) * 2004-05-28 2005-12-01 Middleton Lance M Instruments and methods for reducing and stabilizing bone fractures
US20060203608A1 (en) * 2002-10-07 2006-09-14 Advanced Biomaterial Systems, Inc., A Delaware Corporation Apparatus for mixing and dispensing components
US20070088315A1 (en) * 2004-02-04 2007-04-19 Hans Haindl Medical transfer device
US20080177226A1 (en) * 2005-02-09 2008-07-24 Kaken Pharmaceutical Co., Ltd. Syringe Device and Method of Preparing Medicine Using the Device
US20080300536A1 (en) * 2004-12-16 2008-12-04 Xinming Wang Drug Mixing and Delivery Device
DE102008029856A1 (de) * 2008-02-27 2009-10-01 Arnold Jahn Flasche, Trinkflasche und System zur Erzeugung eines Mischgetränks
US20090320959A1 (en) * 2006-07-27 2009-12-31 Uwe Reuter Device for combining components by means of negative pressure under sterile conditions
US20100084041A1 (en) * 2008-10-02 2010-04-08 Jean-Noel Fehr Manual filling aid with push button fill
WO2010052707A1 (fr) * 2008-11-04 2010-05-14 Situ Gen Ltd. Connecteur à activation double
US20100262293A1 (en) * 2007-11-02 2010-10-14 Vkr Holding A/S Method, system and device for controlling a device related to a building aperture
US20100286661A1 (en) * 2007-11-08 2010-11-11 Lior Raday Vial adaptor and manufacturing method therfor
US20110004184A1 (en) * 2007-10-01 2011-01-06 Karl-Heinz Proksch Device for introducing medicine into an infusion container
US20110147395A1 (en) * 2009-12-17 2011-06-23 Bolland Michael J Multiple container retaining device and method for using same
US8022375B2 (en) 2003-12-23 2011-09-20 Baxter International Inc. Method and apparatus for validation of sterilization
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ES2159542T3 (es) 2001-10-16
PT614653E (pt) 2001-12-28
ATE204453T1 (de) 2001-09-15
EP0614653B1 (fr) 2001-08-22
JPH06239352A (ja) 1994-08-30
EP0614653A3 (fr) 1995-01-04
DK0614653T3 (da) 2001-10-08
DE69428005T2 (de) 2001-12-06
EP0614653A2 (fr) 1994-09-14
DE69428005D1 (de) 2001-09-27

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