US20170313665A1 - Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof - Google Patents
Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof Download PDFInfo
- Publication number
- US20170313665A1 US20170313665A1 US15/523,061 US201515523061A US2017313665A1 US 20170313665 A1 US20170313665 A1 US 20170313665A1 US 201515523061 A US201515523061 A US 201515523061A US 2017313665 A1 US2017313665 A1 US 2017313665A1
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- US
- United States
- Prior art keywords
- triazol
- chlorophenyl
- methyl
- trifluoro
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- UEPVLORYRWERPC-SJCJKPOMSA-N C[C@H](O)C1=NC(CN2N=C(C3=CC=C(Cl)C=C3)N(C[C@H](O)C(F)(F)F)C2=O)=NN1C1=CC=CC=C1Cl Chemical compound C[C@H](O)C1=NC(CN2N=C(C3=CC=C(Cl)C=C3)N(C[C@H](O)C(F)(F)F)C2=O)=NN1C1=CC=CC=C1Cl UEPVLORYRWERPC-SJCJKPOMSA-N 0.000 description 1
- DYLKTKZFTXKKFU-INIZCTEOSA-N O=C1N(CC2=NN(C3=CC(F)=CC(Cl)=C3)C(CO)=N2)N=C(C2=CC=C(Cl)C=C2)N1C[C@H](O)C(F)(F)F Chemical compound O=C1N(CC2=NN(C3=CC(F)=CC(Cl)=C3)C(CO)=N2)N=C(C2=CC=C(Cl)C=C2)N1C[C@H](O)C(F)(F)F DYLKTKZFTXKKFU-INIZCTEOSA-N 0.000 description 1
- CHSILNGVDWHEAJ-INIZCTEOSA-N O=C1N(CC2=NN(C3=CC(F)=CC(F)=C3)C(CO)=N2)N=C(C2=CC=C(Cl)C=C2)N1C[C@H](O)C(F)(F)F Chemical compound O=C1N(CC2=NN(C3=CC(F)=CC(F)=C3)C(CO)=N2)N=C(C2=CC=C(Cl)C=C2)N1C[C@H](O)C(F)(F)F CHSILNGVDWHEAJ-INIZCTEOSA-N 0.000 description 1
- CQCGLWUPSPPBBY-INIZCTEOSA-N O=C1N(CC2=NN(C3=CC(F)=CC=C3Cl)C(CO)=N2)N=C(C2=CC=C(Cl)C=C2)N1C[C@H](O)C(F)(F)F Chemical compound O=C1N(CC2=NN(C3=CC(F)=CC=C3Cl)C(CO)=N2)N=C(C2=CC=C(Cl)C=C2)N1C[C@H](O)C(F)(F)F CQCGLWUPSPPBBY-INIZCTEOSA-N 0.000 description 1
- GBPJUHNUSIGJBG-INIZCTEOSA-N O=C1N(CC2=NN(C3=CC=CC(Cl)=C3)C(CO)=N2)N=C(C2=CC=C(Cl)C=C2)N1C[C@H](O)C(F)(F)F Chemical compound O=C1N(CC2=NN(C3=CC=CC(Cl)=C3)C(CO)=N2)N=C(C2=CC=C(Cl)C=C2)N1C[C@H](O)C(F)(F)F GBPJUHNUSIGJBG-INIZCTEOSA-N 0.000 description 1
- FVJJYTZFOAEEFG-INIZCTEOSA-N O=C1N(CC2=NN(C3=CC=CC(F)=C3)C(CO)=N2)N=C(C2=CC=C(Cl)C=C2)N1C[C@H](O)C(F)(F)F Chemical compound O=C1N(CC2=NN(C3=CC=CC(F)=C3)C(CO)=N2)N=C(C2=CC=C(Cl)C=C2)N1C[C@H](O)C(F)(F)F FVJJYTZFOAEEFG-INIZCTEOSA-N 0.000 description 1
- QXSMHJYKQTZSPY-INIZCTEOSA-N O=C1N(CC2=NN(C3=CC=CC=C3C(F)(F)F)C(CO)=N2)N=C(C2=CC=C(Cl)C=C2)N1C[C@H](O)C(F)(F)F Chemical compound O=C1N(CC2=NN(C3=CC=CC=C3C(F)(F)F)C(CO)=N2)N=C(C2=CC=C(Cl)C=C2)N1C[C@H](O)C(F)(F)F QXSMHJYKQTZSPY-INIZCTEOSA-N 0.000 description 1
- PLGISEQGTKQAGY-INIZCTEOSA-N O=C1N(CC2=NN(C3=CC=CC=C3Cl)C(CO)=N2)N=C(C2=CC=C(Cl)C=C2)N1C[C@H](O)C(F)(F)F Chemical compound O=C1N(CC2=NN(C3=CC=CC=C3Cl)C(CO)=N2)N=C(C2=CC=C(Cl)C=C2)N1C[C@H](O)C(F)(F)F PLGISEQGTKQAGY-INIZCTEOSA-N 0.000 description 1
- QIFYQCSEJVGOAB-JTQLQIEISA-N O=C1N(CC2=NNC(CO)=N2)N=C(C2=CC=C(Cl)C=C2)N1C[C@H](O)C(F)(F)F Chemical compound O=C1N(CC2=NNC(CO)=N2)N=C(C2=CC=C(Cl)C=C2)N1C[C@H](O)C(F)(F)F QIFYQCSEJVGOAB-JTQLQIEISA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Definitions
- the liquid content of the human body is subject to various physiological control mechanisms, the purpose of which is to keep it constant (volume homeostasis).
- both the volume filling of the vascular system and also the osmolarity of the plasma are continuously recorded by appropriate sensors (baroreceptors and osmoreceptors).
- the information which these sensors supply to the relevant centers in the brain regulates drinking behaviour and controls fluid excretion via the kidneys by means of humoral and neural signals.
- the peptide hormone vasopressin is of central importance in this [Schrier R. W., Abraham W. T., New Engl. J. Med. 341, 577-585 (1999)].
- Vasopressin exerts its action mainly via binding to three receptors, which are classified as V1a, V1b and V2 receptors and which belong to the family of G protein-coupled receptors.
- V1a receptors are mainly located on the cells of the vascular smooth musculature. Their activation gives rise to vasoconstriction, as a result of which the peripheral resistance and blood pressure rise. Apart from this, V1a receptors are also detectable in the liver.
- V1b receptors also named V3 receptors
- vasopressin regulates the basal and stress-induced secretion of adrenocorticotropic hormone (ACTH) via the V1b receptor.
- CSH corticotropin-releasing hormone
- V2 receptors are located in the distal tubular epithelium and the epithelium of the collecting tubules in the kidney. Their activation renders these epithelia permeable to water. This phenomenon is due to the incorporation of aquaporins (special water channels) in the luminal membrane of the epithelial cells.
- V2 receptor antagonists cause increased water excretion, without substantially increasing the excretion of electrolytes. This means that with V2 antagonist drugs, volume homeostasis can be restored without affecting electrolyte homeostasis.
- drugs with V2 antagonistic activity appear particularly suitable for the treatment of all disease conditions which are associated with an overloading of the body with water, without the electrolytes being adequately increased in parallel.
- hyponatremia sodium concentration ⁇ 135 mmol/L
- hyponatremia sodium concentration ⁇ 135 mmol/L
- comatose states and death are imminent.
- hypovolemic euvolemic
- hypervolemic hyponatremia The forms of hypervolemia with edema formation are clinically significant. Typical examples of these are the syndrome of inappropriate ADH/vasopressin secretion (SIADH) (e.g.
- V1a and V2 vasopressin receptors
- V1a and V2 vasopressin receptors
- V1a and V2 vasopressin receptors
- the provision of such combined vasopressin antagonists also appears to make sense inasmuch as a volume diminution mediated solely via V2 receptor blockade can entail the stimulation of osmoreceptors and, as a result, may lead to a further compensatory increase in vasopressin release.
- vasopressin such as for example vasoconstriction and heart muscle hypertrophy
- WO 2011/104322-A1 a particular group of bis-aryl-bonded 1,2,4-triazol-3-ones, including 5-phenyl-1,2,4-triazol-3-yl and 1-phenyl-1,2,3-triazol-4-yl derivatives thereof, has been disclosed as antagonists of vasopressin V1a and/or V2 receptors being useful for the treatment and/or prevention of cardiovascular diseases.
- candidate compounds were frequently compromised by an unsatisfactory aquaretic potency when evaluated in vivo following peroral administration to conscious rats.
- a robust aquaretic efficacy is a desirable prerequisite for the treatment of disease conditions that are associated with an overloading of the body with water, such as, for example, in congestive heart failure.
- a significant increase in aquaretic potency would also help towards reducing the amount of substance which is going to be required to achieve and maintain the desired therapeutic effect, thus limiting the potential for unacceptable side effects and/or unwanted drug-drug interactions during the treatment of patients which might already be at high risk, such as, for example, in acute or chronic heart failure or renal failure.
- the technical problem to be solved according to the present invention may therefore be seen in identifying and providing new compounds that act as potent antagonists of both vasopressin V1a and V2 receptors and, in addition, exhibit a substantial increase in aquaretic potency in vivo.
- Compounds according to the invention are the compounds of the formula (I) and their salts, solvates and solvates of the salts, the compounds included in the formula (I) of the formulae mentioned in the following and their salts, solvates and solvates of the salts, and the compounds included in the formula (I) and mentioned in the following as process products and/or embodiment examples and their salts, solvates and solvates of the salts, where the compounds included in the formula (I) and mentioned in the following are not already salts, solvates and solvates of the salts.
- Solvates in the context of the invention are designated as those forms of the compounds according to the invention which form a complex in the solid or liquid state by stoichiometric coordination with solvent molecules. Hydrates are a specific form of solvates, in which the coordination takes place with water. Hydrates are preferred solvates in the context of the present invention.
- the compounds of this invention may, either by nature of asymmetric centers or by restricted rotation, be present in the form of isomers (enantiomers, diastereomers). Any isomer may be present in which the asymmetric center is in the (R)-, (S)-, or (R,S)-configuration.
- isotopes for example of deuterium
- isotopes can lead to particular therapeutic benefits as a consequence of greater metabolic stability of the compound, for example an extension of the half-life in the body or a reduction in the active dose required.
- modifications of the compounds according to the invention may therefore in some cases also constitute a preferred embodiment of the present invention.
- Isotopic variants of the compounds according to the invention can be prepared by processes known to those skilled in the art, for example by the methods described below and the methods described in the working examples, by using corresponding isotopic modifications of the particular reagents and/or starting compounds therein.
- the present invention relates to compounds of formula (I), wherein
- the present invention relates to compounds according to formula (I) selected from the group consisting of the following compounds
- R 1 , R 2A and R 2B have the meanings described above, optionally followed, where appropriate, by (i) separating the compounds of formula (I) thus obtained into their respective diastereomers, preferably using chromatographic methods, and/or (ii) converting the compounds of formula (I) into their respective hydrates, solvates, salts and/or hydrates or solvates of the salts by treatment with the corresponding solvents and/or acids or bases.
- the 1,2,4-triazole derivative of formula (V) produced by this reaction may also be present in other tautomeric forms, such as (V-A) or (V-B)
- the compounds of the invention are suitable for treating urological diseases and diseases of the male and female urogenital system such as, for example, benign prostatic syndrome (BPS), benign prostatic hyperplasia (BPH), benign prostatic enlargement (BPE), bladder outlet obstruction (BOO), lower urinary tract syndromes (LUTS), neurogenic overactive bladder (OAB), interstitial cystitis (IC), urinary incontinence (UI), for example mixed, urge, stress and overflow incontinence (MUI, UUI, SUI, OUI), pelvic pains, erectile dysfunction and female sexual dysfunction.
- BPS benign prostatic syndrome
- BPH benign prostatic hyperplasia
- BPE benign prostatic enlargement
- BOO bladder outlet obstruction
- LUTS lower urinary tract syndromes
- OAB neurogenic overactive bladder
- IC interstitial cystitis
- UI urinary incontinence
- MUI urinary incontinence
- MUI UUI, SUI, OUI
- reaction mixture was stirred at room temperature for 5 days, after which extra boronic acid (54.4 mg, 0.36 mmol, 0.5 eq.) was added due to incomplete conversion.
- extra boronic acid 54.4 mg, 0.36 mmol, 0.5 eq.
- the reaction mixture was diluted with MTBE and then quenched with aqueous hydrochloric acid (0.5 M). After phase separation, the aqueous phase was extracted twice with MTBE. The combined organic phases were dried over sodium sulfate, filtered, and concentrated in vacuo.
- the crude product was purified by preparative HPLC [method 4], and the desired compound (73 mg, 0.14 mmol) was obtained (yield 22.4%, 98% purity).
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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PCT/EP2015/075200 WO2016071212A1 (en) | 2014-11-03 | 2015-10-30 | Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof |
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US14/930,157 Active 2035-11-27 US9771352B2 (en) | 2014-11-03 | 2015-11-02 | Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof |
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